SitesBLAST – Find functional sites

 

SitesBLAST

Comparing WP_012976561.1 NCBI__GCF_000010725.1:WP_012976561.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 3 hits to proteins with known functional sites (download)

1kofA Crystal structure of gluconate kinase (see paper)
39% identity, 91% coverage: 2:149/163 of query aligns to 8:156/171 of 1kofA

query
sites
1kofA
I
 
I
V
 
Y
V
 
V
V
 
L
M
 
M
G
 
G
V
 
V
A
x
S
G
|
G
C
 
S
G
|
G
K
|
K
T
x
S
T
x
A
V
 
V
G
 
A
Q
 
S
M
 
E
L
 
V
A
 
A
A
 
H
R
 
Q
L
 
L
G
 
H
C
 
A
G
 
A
F
 
F
S
 
L
D
 
D
A
 
G
D
 
D
S
 
F
F
 
L
H
 
H
P
 
P
P
 
R
A
 
R
N
 
N
V
 
I
E
 
E
K
 
K
M
 
M
R
 
A
A
 
S
G
 
G
I
 
E
A
 
P
L
 
L
G
 
N
D
 
D
D
 
D
D
 
D
R
 
R
W
 
K
P
 
P
W
 
W
L
 
L
A
 
Q
A
 
A
L
 
L
R
 
N
R
 
D
A
 
A
M
 
A
D
 
F
G
 
A
W
 
M
L
 
Q
A
 
R
E
 
T
G
 
N
A
 
K
S
 
V
H
 
S
V
 
L
V
 
I
A
 
V
C
 
C
S
 
S
A
 
A
L
 
L
R
 
K
Q
 
K
V
 
H
Y
 
Y
R
 
R
E
 
D
I
 
L
L
 
L
S
 
R
P
 
E
A
 
-
G
 
G
E
 
N
P
 
P
K
 
-
G
 
-
T
 
N
V
 
L
V
 
S
F
 
F
V
 
I
H
 
Y
L
 
L
T
 
K
G
 
G
S
 
D
P
 
F
E
 
D
L
 
V
I
 
I
G
 
E
R
 
S
R
|
R
L
 
L
R
 
K
A
 
A
R
 
R
Q
 
K
G
 
G
H
 
H
Y
 
F
M
 
F
N
 
K
P
 
T
A
 
Q
L
 
M
L
 
L
E
 
V
S
 
T
Q
 
Q
F
 
F
A
 
E
T
 
T
L
 
L
E
 
Q
A
 
E
P
 
P
-
 
G
-
 
A
-
 
D
-
 
E
E
 
T
D
 
D
A
 
V
I
 
L
V
 
V
A
 
V
D
 
D
V
 
I
G
 
D
R
 
Q

Sites not aligning to the query:

1ko8A Crystal structure of gluconate kinase (see paper)
39% identity, 91% coverage: 2:149/163 of query aligns to 8:156/172 of 1ko8A

query
sites
1ko8A
I
 
I
V
 
Y
V
 
V
V
 
L
M
 
M
G
 
G
V
 
V
A
x
S
G
 
G
C
 
S
G
 
G
K
 
K
T
 
S
T
 
A
V
 
V
G
 
A
Q
 
S
M
 
E
L
 
V
A
 
A
A
 
H
R
 
Q
L
 
L
G
 
H
C
 
A
G
 
A
F
 
F
S
 
L
D
 
D
A
 
G
D
 
D
S
 
F
F
 
L
H
 
H
P
 
P
P
 
R
A
 
R
N
 
N
V
 
I
E
 
E
K
 
K
M
 
M
R
 
A
A
 
S
G
 
G
I
 
E
A
 
P
L
 
L
G
 
N
D
 
D
D
 
D
D
 
D
R
 
R
W
 
K
P
 
P
W
 
W
L
 
L
A
 
Q
A
 
A
L
 
L
R
 
N
R
 
D
A
 
A
M
 
A
D
 
F
G
 
A
W
 
M
L
 
Q
A
 
R
E
 
T
G
 
N
A
 
K
S
 
V
H
 
S
V
 
L
V
 
I
A
 
V
C
 
C
S
 
S
A
 
A
L
 
L
R
 
K
Q
 
K
V
 
H
Y
 
Y
R
 
R
E
 
D
I
 
L
L
 
L
S
 
R
P
 
E
A
 
-
G
 
G
E
 
N
P
 
P
K
 
-
G
 
-
T
 
N
V
 
L
V
 
S
F
 
F
V
 
I
H
 
Y
L
 
L
T
 
K
G
 
G
S
 
D
P
 
F
E
 
D
L
 
V
I
 
I
G
 
E
R
 
S
R
 
R
L
|
L
R
 
K
A
 
A
R
 
R
Q
 
K
G
 
G
H
 
H
Y
 
F
M
 
F
N
 
K
P
 
T
A
 
Q
L
 
M
L
 
L
E
 
V
S
 
T
Q
 
Q
F
 
F
A
 
E
T
 
T
L
 
L
E
 
Q
A
 
E
P
 
P
-
 
G
-
 
A
-
 
D
-
 
E
E
 
T
D
 
D
A
 
V
I
 
L
V
 
V
A
 
V
D
 
D
V
 
I
G
 
D
R
 
Q

1ko5A Crystal structure of gluconate kinase (see paper)
39% identity, 91% coverage: 2:149/163 of query aligns to 8:156/172 of 1ko5A

query
sites
1ko5A
I
 
I
V
 
Y
V
 
V
V
 
L
M
 
M
G
 
G
V
 
V
A
x
S
G
|
G
C
 
S
G
|
G
K
|
K
T
x
S
T
 
A
V
 
V
G
 
A
Q
 
S
M
 
E
L
 
V
A
 
A
A
 
H
R
 
Q
L
 
L
G
 
H
C
 
A
G
 
A
F
 
F
S
 
L
D
 
D
A
 
G
D
 
D
S
 
F
F
 
L
H
 
H
P
 
P
P
 
R
A
 
R
N
 
N
V
 
I
E
 
E
K
 
K
M
 
M
R
 
A
A
 
S
G
 
G
I
 
E
A
 
P
L
 
L
G
 
N
D
 
D
D
 
D
D
 
D
R
 
R
W
 
K
P
 
P
W
 
W
L
 
L
A
 
Q
A
 
A
L
 
L
R
 
N
R
 
D
A
 
A
M
 
A
D
 
F
G
 
A
W
 
M
L
 
Q
A
 
R
E
 
T
G
 
N
A
 
K
S
 
V
H
 
S
V
 
L
V
 
I
A
 
V
C
 
C
S
 
S
A
 
A
L
 
L
R
 
K
Q
 
K
V
 
H
Y
 
Y
R
 
R
E
 
D
I
 
L
L
 
L
S
 
R
P
 
E
A
 
-
G
 
G
E
 
N
P
 
P
K
 
-
G
 
-
T
 
N
V
 
L
V
 
S
F
 
F
V
 
I
H
 
Y
L
 
L
T
 
K
G
 
G
S
 
D
P
 
F
E
 
D
L
 
V
I
 
I
G
 
E
R
 
S
R
|
R
L
 
L
R
 
K
A
 
A
R
|
R
Q
 
K
G
 
G
H
 
H
Y
 
F
M
 
F
N
 
K
P
 
T
A
 
Q
L
 
M
L
 
L
E
 
V
S
 
T
Q
 
Q
F
 
F
A
 
E
T
 
T
L
 
L
E
 
Q
A
 
E
P
 
P
-
 
G
-
 
A
-
 
D
-
 
E
E
 
T
D
 
D
A
 
V
I
 
L
V
 
V
A
 
V
D
 
D
V
 
I
G
 
D
R
 
Q

Sites not aligning to the query:

Query Sequence

>WP_012976561.1 NCBI__GCF_000010725.1:WP_012976561.1
MIVVVMGVAGCGKTTVGQMLAARLGCGFSDADSFHPPANVEKMRAGIALGDDDRWPWLAA
LRRAMDGWLAEGASHVVACSALRQVYREILSPAGEPKGTVVFVHLTGSPELIGRRLRARQ
GHYMNPALLESQFATLEAPEDAIVADVGRSPAEIVEDVLHRLP

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory