Comparing WP_012976790.1 NCBI__GCF_000010725.1:WP_012976790.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
4ur8A Crystal structure of keto-deoxy-d-galactarate dehydratase complexed with 2-oxoadipic acid (see paper)
56% identity, 98% coverage: 1:297/303 of query aligns to 1:296/304 of 4ur8A
5hwnB Crystal structure of keto-deoxy-d-galactarate dehydratase complexed with pyruvate (see paper)
56% identity, 98% coverage: 1:297/303 of query aligns to 1:296/310 of 5hwnB
4i7wA Agrobacterium tumefaciens dhdps with lysine and pyruvate
34% identity, 74% coverage: 19:242/303 of query aligns to 10:238/294 of 4i7wA
Q8UGL3 4-hydroxy-tetrahydrodipicolinate synthase; HTPA synthase; EC 4.3.3.7 from Agrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens (strain C58)) (see paper)
34% identity, 77% coverage: 19:252/303 of query aligns to 10:244/294 of Q8UGL3
7mjfA Crystal structure of candidatus liberibacter solanacearum dihydrodipicolinate synthase with pyruvate and succinic semi-aldehyde bound in active site
30% identity, 87% coverage: 19:282/303 of query aligns to 10:272/296 of 7mjfA
Sites not aligning to the query:
7lvlA Dihydrodipicolinate synthase bound with allosteric inhibitor (s)- lysine from candidatus liberibacter solanacearum
30% identity, 87% coverage: 19:282/303 of query aligns to 10:272/296 of 7lvlA
Q07607 4-hydroxy-tetrahydrodipicolinate synthase; HTPA synthase; Protein MosA; EC 4.3.3.7 from Rhizobium meliloti (Ensifer meliloti) (Sinorhizobium meliloti) (see paper)
30% identity, 93% coverage: 12:293/303 of query aligns to 3:281/292 of Q07607
4dxvA Crystal structure of dihydrodipicolinate synthase from acinetobacter baumannii complexed with mg and cl ions at 1.80 a resolution
38% identity, 51% coverage: 19:173/303 of query aligns to 10:167/291 of 4dxvA
Sites not aligning to the query:
3u8gA Crystal structure of the complex of dihydrodipicolinate synthase from acinetobacter baumannii with oxalic acid at 1.80 a resolution
38% identity, 51% coverage: 19:173/303 of query aligns to 10:167/291 of 3u8gA
Sites not aligning to the query:
3tdfA Crystal structure of the complex of dihydrodipicolinate synthase from acinetobacter baumannii with 2-ketobutanoic acid at 1.99 a resolution
38% identity, 51% coverage: 19:173/303 of query aligns to 10:167/291 of 3tdfA
Sites not aligning to the query:
3tceA Crystal structure of the complex of dihydrodipicolinate synthase from acinetobacter baumannii with 5-hydroxylysine at 2.6 a resolution
38% identity, 51% coverage: 19:173/303 of query aligns to 10:167/291 of 3tceA
Sites not aligning to the query:
3rk8A Crystal structure of the chloride inhibited dihydrodipicolinate synthase from acinetobacter baumannii complexed with pyruvate at 1.8 a resolution
38% identity, 51% coverage: 19:173/303 of query aligns to 10:167/291 of 3rk8A
Sites not aligning to the query:
3pueB Crystal structure of the complex of dhydrodipicolinate synthase from acinetobacter baumannii with lysine at 2.6a resolution
38% identity, 51% coverage: 19:173/303 of query aligns to 10:167/291 of 3pueB
Sites not aligning to the query:
4m19A Dihydrodipicolinate synthase from c. Jejuni with pyruvate bound to the active site and lysine bound to allosteric site (see paper)
35% identity, 53% coverage: 13:174/303 of query aligns to 6:171/296 of 4m19A
Sites not aligning to the query:
6u01B Dihydrodipicolinate synthase (dhdps) from c.Jejuni, n84d mutant with pyruvate bound in the active site (see paper)
35% identity, 53% coverage: 13:174/303 of query aligns to 6:171/296 of 6u01B
Sites not aligning to the query:
7kkdB Dihydrodipicolinate synthase (dhdps) from c.Jejuni, n84a mutant with pyruvate bound in the active site and r,r-bislysine bound at the allosteric site
35% identity, 53% coverage: 13:174/303 of query aligns to 16:181/306 of 7kkdB
7kg2A Dihydrodipicolinate synthase (dhdps) from c.Jejuni, h59k mutant with pyruvate bound in the active site and l-histidine bound at the allosteric site
35% identity, 53% coverage: 13:174/303 of query aligns to 6:171/296 of 7kg2A
1xxxA Crystal structure of dihydrodipicolinate synthase (dapa, rv2753c) from mycobacterium tuberculosis (see paper)
27% identity, 92% coverage: 14:293/303 of query aligns to 11:285/296 of 1xxxA
5j5dA Crystal structure of dihydrodipicolinate synthase from mycobacterium tuberculosis in complex with alpha-ketopimelic acid (see paper)
27% identity, 92% coverage: 14:293/303 of query aligns to 12:286/297 of 5j5dA
P9WP25 4-hydroxy-tetrahydrodipicolinate synthase; HTPA synthase; EC 4.3.3.7 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
27% identity, 92% coverage: 14:293/303 of query aligns to 15:289/300 of P9WP25
>WP_012976790.1 NCBI__GCF_000010725.1:WP_012976790.1
MEPQALKAVVSEGLLSFPLTDFTADGGFEPGGYARRLEWLKPYGASALFAAGGTGELFSL
TPDEHKSIVSLAVEVCGKEVPIIAGVGYSTRIAVEMARAAEKAGAAGILVLPHYLTEADQ
EGVAAHVEAICKSVGIGVIIYNRATCKLSADRLAALAERCPNLIGFKDGLGDIELMTTIR
RRMGDRFSYLGGLPTAEVYAAAYRAIGVPVYSSAVFNFIPRTAMEFYHAVSAGDTATTDR
LLDQFFLPYLAIRNRKAGYAVSIVKAGAAIVGRSAGPVRAPLTDCAPAEVEELRVLIEAL
GPQ
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory