Comparing WP_012976848.1 NCBI__GCF_000010725.1:WP_012976848.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
Q8UGL3 4-hydroxy-tetrahydrodipicolinate synthase; HTPA synthase; EC 4.3.3.7 from Agrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens (strain C58)) (see paper)
35% identity, 81% coverage: 11:252/300 of query aligns to 4:245/294 of Q8UGL3
4i7wA Agrobacterium tumefaciens dhdps with lysine and pyruvate
35% identity, 81% coverage: 11:252/300 of query aligns to 4:245/294 of 4i7wA
7mjfA Crystal structure of candidatus liberibacter solanacearum dihydrodipicolinate synthase with pyruvate and succinic semi-aldehyde bound in active site
33% identity, 89% coverage: 15:280/300 of query aligns to 8:273/296 of 7mjfA
7lvlA Dihydrodipicolinate synthase bound with allosteric inhibitor (s)- lysine from candidatus liberibacter solanacearum
33% identity, 89% coverage: 15:280/300 of query aligns to 8:273/296 of 7lvlA
Q07607 4-hydroxy-tetrahydrodipicolinate synthase; HTPA synthase; Protein MosA; EC 4.3.3.7 from Rhizobium meliloti (Ensifer meliloti) (Sinorhizobium meliloti) (see paper)
34% identity, 96% coverage: 11:297/300 of query aligns to 4:288/292 of Q07607
4dxvA Crystal structure of dihydrodipicolinate synthase from acinetobacter baumannii complexed with mg and cl ions at 1.80 a resolution
35% identity, 89% coverage: 9:274/300 of query aligns to 2:261/291 of 4dxvA
3u8gA Crystal structure of the complex of dihydrodipicolinate synthase from acinetobacter baumannii with oxalic acid at 1.80 a resolution
35% identity, 89% coverage: 9:274/300 of query aligns to 2:261/291 of 3u8gA
3tdfA Crystal structure of the complex of dihydrodipicolinate synthase from acinetobacter baumannii with 2-ketobutanoic acid at 1.99 a resolution
35% identity, 89% coverage: 9:274/300 of query aligns to 2:261/291 of 3tdfA
3tceA Crystal structure of the complex of dihydrodipicolinate synthase from acinetobacter baumannii with 5-hydroxylysine at 2.6 a resolution
35% identity, 89% coverage: 9:274/300 of query aligns to 2:261/291 of 3tceA
3rk8A Crystal structure of the chloride inhibited dihydrodipicolinate synthase from acinetobacter baumannii complexed with pyruvate at 1.8 a resolution
35% identity, 89% coverage: 9:274/300 of query aligns to 2:261/291 of 3rk8A
3pueB Crystal structure of the complex of dhydrodipicolinate synthase from acinetobacter baumannii with lysine at 2.6a resolution
35% identity, 89% coverage: 9:274/300 of query aligns to 2:261/291 of 3pueB
4pfmA Shewanella benthica dhdps with lysine and pyruvate
34% identity, 83% coverage: 9:257/300 of query aligns to 3:250/295 of 4pfmA
Q5HG25 4-hydroxy-tetrahydrodipicolinate synthase; HTPA synthase; EC 4.3.3.7 from Staphylococcus aureus (strain COL) (see paper)
32% identity, 73% coverage: 14:232/300 of query aligns to 10:227/295 of Q5HG25
3l21B The crystal structure of a dimeric mutant of dihydrodipicolinate synthase (dapa, rv2753c) from mycobacterium tuberculosis - dhdps- a204r
33% identity, 83% coverage: 7:255/300 of query aligns to 5:250/295 of 3l21B
3di1B Crystal structure of the staphylococcus aureus dihydrodipicolinate synthase-pyruvate complex (see paper)
32% identity, 73% coverage: 14:232/300 of query aligns to 10:227/291 of 3di1B
1o5kA Crystal structure of dihydrodipicolinate synthase (tm1521) from thermotoga maritima at 1.80 a resolution
30% identity, 81% coverage: 15:257/300 of query aligns to 9:253/295 of 1o5kA
Q9X1K9 4-hydroxy-tetrahydrodipicolinate synthase; HTPA synthase; EC 4.3.3.7 from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see paper)
30% identity, 81% coverage: 15:257/300 of query aligns to 8:252/294 of Q9X1K9
2wpbA Crystal structure of the e192n mutant of e. Coli n-acetylneuraminic acid lyase in complex with pyruvate and the inhibitor (2r,3r)-2,3,4- trihydroxy-n,n-dipropylbutanamide in space group p21 crystal form i (see paper)
30% identity, 91% coverage: 7:278/300 of query aligns to 8:278/302 of 2wpbA
P0A6L4 N-acetylneuraminate lyase; AcNeu lyase; NAL; Neu5Ac lyase; N-acetylneuraminate pyruvate-lyase; N-acetylneuraminic acid aldolase; NALase; Sialate lyase; Sialic acid aldolase; Sialic acid lyase; EC 4.1.3.3 from Escherichia coli (strain K12) (see 5 papers)
30% identity, 91% coverage: 7:278/300 of query aligns to 3:273/297 of P0A6L4
Sites not aligning to the query:
3lbcD D-sialic acid aldolase complexed with l-arabinose
30% identity, 91% coverage: 7:278/300 of query aligns to 3:273/296 of 3lbcD
>WP_012976848.1 NCBI__GCF_000010725.1:WP_012976848.1
MSKTSGSKIGGPFVAIVTPFDGDERVEIAALRRQVKRQASAGNGVFCAGTNGEFYALSFD
EKLAVAEICVEAAAGQVPVLAHIGEISTHQTIALGRAIQALGVKAVSAITPSFIACSQAE
LIAHYLRVADALTVPLYLYNIPARTGNTLEPETARVLADHPNIIGIKDSAGSQESLDGFL
AIARERGDFDVLVGPDSLVLHGLRNGAAGCISGLGNIAPVTLNGIHAAFVAGDAAAAEAH
QTHFSTLRKELYALGFPPAMVKRALYRAMPEVGLSRAPVLIANEADNRIKELAARYAEAV
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory