SitesBLAST
Comparing WP_012991556.1 NCBI__GCF_000025605.1:WP_012991556.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 19 hits to proteins with known functional sites (download)
7e1sC Crystal structure of dehydrogenase/isomerase fabx from helicobacter pylori in complex with octanoyl-acp (see paper)
55% identity, 93% coverage: 2:360/385 of query aligns to 8:364/366 of 7e1sC
- binding S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] octanethioate: L104 (= L98), A129 (= A123), G130 (= G124), L131 (= L125), I150 (= I143), I151 (≠ V144), S152 (= S145), E178 (= E171), H185 (= H178), Y280 (= Y274), I324 (= I318), L328 (= L322)
- binding flavin mononucleotide: G25 (= G19), G26 (= G20), M27 (= M21), G28 (= G22), N102 (= N96), E178 (= E171), S182 (= S175), G183 (= G176), G223 (= G216), G224 (= G217), M244 (≠ I237), A245 (= A238), T246 (= T239), L249 (≠ I242), F342 (≠ I336), T343 (≠ S337)
- binding iron/sulfur cluster: C303 (= C297), N306 (≠ H300), C307 (= C301), V308 (= V302), C311 (= C305), G314 (= G308), A317 (= A311), C323 (= C317), I324 (= I318)
- binding : L131 (= L125), T133 (≠ L127), N134 (≠ R128), K155 (≠ R148), I159 (≠ L152), K162 (≠ R155), R163 (≠ T156), R167 (≠ K160)
7e1sA Crystal structure of dehydrogenase/isomerase fabx from helicobacter pylori in complex with octanoyl-acp (see paper)
55% identity, 93% coverage: 2:360/385 of query aligns to 8:364/366 of 7e1sA
- binding S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] octanethioate: L104 (= L98), A129 (= A123), G130 (= G124), I150 (= I143), I151 (≠ V144), S152 (= S145), E178 (= E171), H185 (= H178), G187 (= G180), Y280 (= Y274), L328 (= L322)
- binding flavin mononucleotide: G25 (= G19), G26 (= G20), M27 (= M21), G28 (= G22), N102 (= N96), L104 (= L98), E178 (= E171), G183 (= G176), G223 (= G216), G224 (= G217), Q243 (= Q236), M244 (≠ I237), A245 (= A238), T246 (= T239)
- binding iron/sulfur cluster: C303 (= C297), N306 (≠ H300), C307 (= C301), V308 (= V302), C311 (= C305), G314 (= G308), A317 (= A311), C323 (= C317), I324 (= I318)
7e1rA Crystal structure of dehydrogenase/isomerase fabx from helicobacter pylori in complex with holo-acp (see paper)
55% identity, 93% coverage: 2:360/385 of query aligns to 8:364/366 of 7e1rA
- binding flavin mononucleotide: G25 (= G19), G26 (= G20), M27 (= M21), G28 (= G22), N102 (= N96), L104 (= L98), E178 (= E171), G183 (= G176), G224 (= G217), Q243 (= Q236), M244 (≠ I237), A245 (= A238), T246 (= T239), F342 (≠ I336)
- binding N~3~-[(2S)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-N-(2-sulfanylethyl)-beta-alaninamide: G128 (= G122), A129 (= A123), G130 (= G124), E178 (= E171), H185 (= H178), G187 (= G180)
- binding iron/sulfur cluster: C303 (= C297), N306 (≠ H300), C307 (= C301), V308 (= V302), C311 (= C305), G314 (= G308), A317 (= A311), C323 (= C317), I324 (= I318)
7e1qA Crystal structure of dehydrogenase/isomerase fabx from helicobacter pylori (see paper)
55% identity, 93% coverage: 2:360/385 of query aligns to 8:364/366 of 7e1qA
- binding flavin mononucleotide: G25 (= G19), G26 (= G20), M27 (= M21), G28 (= G22), N102 (= N96), L104 (= L98), E178 (= E171), S182 (= S175), G183 (= G176), G223 (= G216), G224 (= G217), M244 (≠ I237), A245 (= A238), T246 (= T239), F342 (≠ I336)
- binding iron/sulfur cluster: P277 (= P271), C303 (= C297), N306 (≠ H300), C307 (= C301), V308 (= V302), C311 (= C305), G314 (= G308), A317 (= A311), C323 (= C317), I324 (= I318)
7l00C Crystal structure of c. Difficile enoyl-acyl carrier protein reductase (fabk) in complex with an inhibitor
27% identity, 93% coverage: 6:362/385 of query aligns to 9:305/315 of 7l00C
- binding flavin mononucleotide: G23 (= G19), G24 (= G20), M25 (= M21), A26 (≠ G22), N74 (= N96), E142 (= E171), G146 (≠ S175), G147 (= G176), G174 (= G216), G175 (= G217), Q194 (= Q236), G196 (≠ A238), T197 (= T239), M281 (≠ I336), S285 (≠ N340)
- binding N-[6-(methylsulfonyl)-1,3-benzothiazol-2-yl]-2-[2-(1H-pyrrol-1-yl)-1,3-thiazol-4-yl]acetamide: A26 (≠ G22), M76 (≠ L98), G100 (= G122), A101 (= A123), G102 (= G124), V121 (≠ I143), P123 (≠ S145), H149 (= H178), L266 (vs. gap), M281 (≠ I336)
5gvhA Structure of fabk from thermotoga maritima (see paper)
28% identity, 73% coverage: 10:289/385 of query aligns to 10:243/311 of 5gvhA
- binding flavin mononucleotide: G19 (= G19), G20 (= G20), M21 (= M21), A22 (≠ S26), N70 (= N96), I72 (≠ L98), E138 (= E171), S142 (= S175), G143 (= G176), G170 (= G216), G171 (= G217), Q190 (= Q236), G192 (≠ A238), T193 (= T239)
Sites not aligning to the query:
2z6iB Crystal structure of s. Pneumoniae enoyl-acyl carrier protein reductase (fabk) (see paper)
30% identity, 49% coverage: 94:283/385 of query aligns to 67:236/321 of 2z6iB
- binding calcium ion: E137 (= E171), H144 (= H178), A158 (≠ N205), I161 (≠ G208)
- binding flavin mononucleotide: N69 (= N96), E137 (= E171), A141 (≠ S175), G142 (= G176), G169 (= G216), G170 (= G217), G191 (≠ A238), T192 (= T239)
Sites not aligning to the query:
2z6jA Crystal structure of s. Pneumoniae enoyl-acyl carrier protein reductase (fabk) in complex with an inhibitor (see paper)
29% identity, 49% coverage: 94:283/385 of query aligns to 67:233/307 of 2z6jA
- binding calcium ion: A158 (≠ N205), I161 (≠ G208)
- binding flavin mononucleotide: N69 (= N96), E137 (= E171), A141 (≠ S175), G142 (= G176), G169 (= G216), G170 (= G217), G191 (≠ A238), T192 (= T239)
- binding 2-(4-(2-((3-(5-(pyridin-2-ylthio)thiazol-2-yl)ureido)methyl)-1h-imidazol-4-yl)phenoxy)acetic acid: M71 (≠ L98), L73 (≠ A100), A96 (= A123), G97 (= G124), V116 (≠ I143), P118 (≠ S145), L122 (≠ W157), E137 (= E171), H144 (= H178)
Sites not aligning to the query:
5lsmA Crystal structure of nitronate monooxygenase (so_0471) from shewanella oneidensis mr-1
25% identity, 72% coverage: 12:287/385 of query aligns to 9:278/339 of 5lsmA
- binding flavin mononucleotide: A16 (≠ G19), P17 (≠ G20), M18 (= M21), A19 (≠ G22), N67 (≠ V68), H123 (≠ G122), A170 (≠ S175), G171 (= G176), G207 (= G216), G208 (= G217), G229 (≠ A238), T230 (= T239)
Sites not aligning to the query:
4iqlA Crystal structure of porphyromonas gingivalis enoyl-acp reductase ii (fabk) with cofactors NADPH and fmn (see paper)
25% identity, 72% coverage: 12:288/385 of query aligns to 10:241/313 of 4iqlA
- binding flavin mononucleotide: G18 (= G20), M19 (= M21), V20 (≠ G22), N68 (= N96), S94 (≠ G122), E136 (= E171), A140 (≠ S175), G141 (= G176), G170 (= G216), G171 (= G217), Q190 (= Q236), G192 (≠ A238), T193 (= T239)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: W21 (≠ V23), W21 (≠ V23), W25 (= W27), S44 (≠ Y50), M45 (≠ R51), M45 (≠ R51), H46 (≠ F52), N49 (≠ L55), H52 (≠ R58), H53 (≠ D59), Y73 (≠ I101), P74 (≠ T102), E75 (≠ D103), S202 (≠ D248)
Sites not aligning to the query:
3bw2A Crystal structures and site-directed mutagenesis study of nitroalkane oxidase from streptomyces ansochromogenes (see paper)
23% identity, 91% coverage: 14:362/385 of query aligns to 9:338/347 of 3bw2A
- binding flavin mononucleotide: A14 (≠ G19), P15 (≠ G20), M16 (= M21), A17 (≠ G22), N66 (≠ V68), F68 (≠ T70), H124 (≠ P126), Q167 (≠ E171), A171 (≠ S175), G172 (= G176), G173 (= G177), G210 (= G216), G211 (= G217), G232 (≠ A238), T233 (= T239), W315 (≠ S337)
4q4kA Crystal structure of nitronate monooxygenase from pseudomonas aeruginosa pao1 (see paper)
25% identity, 64% coverage: 12:257/385 of query aligns to 11:258/351 of 4q4kA
- binding flavin mononucleotide: A18 (≠ G19), P19 (≠ G20), M20 (= M21), L21 (≠ V23), N69 (= N96), F71 (≠ L98), H133 (vs. gap), Q176 (≠ E171), A180 (≠ S175), G181 (= G176), G182 (= G177), G217 (= G216), G218 (= G217), G239 (≠ A238), T240 (= T239)
Sites not aligning to the query:
Q9HWH9 Nitronate monooxygenase; NMO; Propionate 3-nitronate monooxygenase; P3N monooxygenase; EC 1.13.12.- from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
25% identity, 64% coverage: 12:257/385 of query aligns to 11:258/351 of Q9HWH9
- L21 (≠ V23) binding FMN
- N69 (= N96) binding FMN
- Q176 (≠ E171) binding FMN
- G181 (= G176) binding FMN
- G218 (= G217) binding FMN
- QMGT 237:240 (≠ QIAT 236:239) binding FMN
3bw3A Crystal structures and site-directed mutagenesis study of nitroalkane oxidase from streptomyces ansochromogenes (see paper)
23% identity, 91% coverage: 14:362/385 of query aligns to 9:338/346 of 3bw3A
- binding flavin mononucleotide: A14 (≠ G19), P15 (≠ G20), M16 (= M21), A17 (≠ G22), N66 (≠ V68), F68 (≠ T70), H124 (≠ P126), A171 (≠ S175), G172 (= G176), G173 (= G177), G210 (= G216), G211 (= G217), G232 (≠ A238), T233 (= T239), W315 (≠ S337)
- binding nitroethane: G18 (≠ V23), Y42 (= Y50), H293 (≠ S299), R300 (≠ N306)
6e2aA Crystal structure of nadh:quinone reductase pa1024 from pseudomonas aeruginosa pao1 in complex with NAD+ (see paper)
27% identity, 32% coverage: 166:288/385 of query aligns to 139:250/326 of 6e2aA
Sites not aligning to the query:
- binding flavin mononucleotide: 21, 22, 23, 74, 123, 287
- binding nicotinamide-adenine-dinucleotide: 23, 76, 77, 79, 260, 269, 287
Q9I4V0 NADH:quinone reductase; EC 1.6.5.9 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
27% identity, 32% coverage: 166:288/385 of query aligns to 140:251/328 of Q9I4V0
Sites not aligning to the query:
- 22:24 binding FMN
- 75 binding FMN
- 124 binding FMN
6bkaA Crystal structure of nitronate monooxygenase from cyberlindnera saturnus (see paper)
22% identity, 41% coverage: 131:287/385 of query aligns to 157:309/374 of 6bkaA
Sites not aligning to the query:
- binding 3,6,9,12,15,18,21,24,27,30,33,36-dodecaoxaoctatriacontane-1,38-diol: 34, 37, 67, 69
- binding flavin mononucleotide: 21, 22, 23, 24, 77, 79, 147
2gjnA Crystal structure of 2-nitropropane dioxygenase complexed with fmn and substrate (see paper)
27% identity, 32% coverage: 166:288/385 of query aligns to 138:249/324 of 2gjnA
Sites not aligning to the query:
4qitA Crystal structure of nitroalkane oxidase from pseudomonas aeruginosa in mutant complex form
24% identity, 64% coverage: 12:257/385 of query aligns to 11:258/350 of 4qitA
- binding flavin mononucleotide: A18 (≠ G19), P19 (≠ G20), M20 (= M21), L21 (≠ V23), N69 (= N96), F71 (≠ L98), H133 (vs. gap), Q176 (≠ E171), A180 (≠ S175), G181 (= G176), G217 (= G216), G218 (= G217), M238 (≠ I237), G239 (≠ A238), T240 (= T239)
- binding nitroethane: F71 (≠ L98), G182 (= G177), S183 (≠ H178)
Sites not aligning to the query:
Query Sequence
>WP_012991556.1 NCBI__GCF_000025605.1:WP_012991556.1
MLPELKIGKIRLEIPIIQGGMGVGISWEKLAGAVAREGAMGVVSAVGTGYRFPELVKRDK
FGRPIGSVYTHSKEALTILIKEAKRISQNRGAIGVNILCAITDYGRVVQDAIEAGADAII
SGAGLPLRLPEYAEGSDVALIPIVSSARALNLICRTWEKKYKRLPDAVILEGPKSGGHQG
FKYEECFMPEYQLENLFPSLLEEANRWGGIPVIVAGGVWSYQDIKWYIDRGAKGVQIATR
FIATHECDAPPIYKEILLKAEEEDIILLKSPVGYPLRVVKTPFVERLLEGYNGWQGCVSH
CVVPCNKGEEAKKVGFCIADRLGAAWLGNYEEGLFISGANGHLLKKQGIISVKELLEILT
GKRPDPTLDHSLDARDSLAVPGSGN
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory