SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing WP_012992424.1 NCBI__GCF_000025605.1:WP_012992424.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 16 hits to proteins with known functional sites (download)

P9WKJ5 Dihydroxy-acid dehydratase; DAD; EC 4.2.1.9 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
47% identity, 99% coverage: 2:551/554 of query aligns to 20:573/575 of P9WKJ5

query
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P9WKJ5

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C64 (≠ G46) binding [2Fe-2S] cluster
D96 (= D78) binding Mg(2+)
C137 (= C119) binding [2Fe-2S] cluster
D138 (= D120) binding Mg(2+)
K139 (= K121) binding via carbamate group; modified: N6-carboxylysine
C214 (= C191) binding [2Fe-2S] cluster
E465 (= E443) binding Mg(2+)
S491 (= S469) mutation to A: Loss of catalytic activity.

6ovtA Crystal structure of ilvd from mycobacterium tuberculosis (see paper)
47% identity, 99% coverage: 2:551/554 of query aligns to 7:560/562 of 6ovtA

query
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6ovtA

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binding fe2/s2 (inorganic) cluster: C51 (≠ G46), G84 (= G79), C124 (= C119), D125 (= D120), A200 (≠ S190), C201 (= C191)
binding magnesium ion: D83 (= D78), D125 (= D120), K126 (= K121), E452 (= E443)

Q9LIR4 Dihydroxy-acid dehydratase, chloroplastic; AthDHAD; DAD; EC 4.2.1.9 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
43% identity, 99% coverage: 3:553/554 of query aligns to 57:607/608 of Q9LIR4

query
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Q9LIR4

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L

F

E

Q

G

D

Q

K

K

T

V

Y

D

D

L

I

I

V

T

S

V

A

F

F

E

Q

G

S

I

Y

G

G

Q

E

L

F

K

V

A

S

G

G

K

S

I

I

D

S

E

D

A

E

K

Q

L

R

K

K

L

T

L

V

E

L

Q

H

T

H

A

S

C

C

P

P

T

G

C

A

G

G

S

A

C
|
C

S

G

G

G

M

M

F

Y

T

T

A

A

N

N

S

T

M

M

N

A

C

S

L

A

T

I

E

E

V

A

L

M

G

G

L

M

G

S

L

L

P

P

G

Y

N

S

G

S

T

S

I

I

P

P

A

A

V

E

D

D

P

P

R

L

R

K

E

L

M

D

L

E

A

C

R

R

Q

L

A

A

A

G

R

K

Q

Y

I

L

M

L

E

E

L

L

L

L

K

K

R

M

D

D

I

L

R

K

P

P

R

R

D

D

I

I

V

I

T

T

V

P

E

K

A

S

L

L

D

R

N

N

A

A

F

M

A

V

V

S

D

V

I

M

A

A

M

L

G

G

G

G

S

S

T

T

N

N

T

A

V

V

L

L

H

H

L

L

L

I

A

A

I

I

A

A

Q

R

E

S

A

V

G

G

I

L

D

E

Y

L

P

T

L

L

E

D

R

D

I

F

D

Q

R

K

I

V

S

S

K

D

A

A

T

V

P

P

T

F

L

L

C

A

K

D

I

L

S

K

P

P

A

S

S

G

H

K

Y

Y

H

V

I

M

Q

E

D

D

L

I

D

H

M

K

V

I

G

G

G

G

I

T

P

P

A

A

L

V

L

L

K

R

E

Y

L

L

I

L

R

E

G

L

N

G

Y

L

L

M

P

-

H

D

P

G

D

D

R

C

P

M

T

T

V

V

S

T

L

G

K

Q

T

T

L

L

R

A

E

Q

I

N

A

L

M

E

S

N

A

V

P

P

D

S

-

L

A

T

D

E

G

G

-

Q

E

E

V

I

I

I

R

R

R

P

I

L

E

S

E

N

P

P

Y

I

S

K

R

E

D

T

G

G

G

H

L

I

A

Q

I

I

L

L

F

R

G

G

N

D

L

L

A

A

P

P

E

D

G

G

A

S

V

V

V

A

K

K

T

I

A

T

G

G

V

-

S

-

E

K

N

E

M

G

L

L

V

Y

F

F

R

S

G

G

K

P

A

A

I

L

C

V

F

F

D

E

S

G

E

E

E

E

E

S

A

M

V

L

E

A

A

A

I

I

L

S

G

A

G

D

R

P

V

M

K

S

-

F

P

K

G

G

H

T

V

V

V

V

V

V

I

I

R

R

Y

G

E

E

G

G

P

P

K

K

G

G

G

G

P

P

G

G

M

M

R

P

E
|
E

M

M

L

L

S

T

P

P

T

T

S

S

A

A

I

I

M

M

G

G

M

A

G

G

L

L

G

G

D

K

K

E

V

C

A

A

L

L

I

L

T

T

D

D

G

G

R

R

F

F

S

S

G

G

G

G

T

S

R

H

G

G

A

F

C

V

V

V

G

G

H

H

I

I

S

C

P

P

E

E

A

A

A

Q

A

E

G

G

G

G

P

P

I

I

G

G

V

L

V

I

K

K

D

N

G

G

D

D

E

I

I

I

L

T

I

I

D

D

I

I

P

G

G

K

R

K

R

R

I

I

E

D

L

T

L

Q

I

V

P

S

E

P

E

E

E

E

L

M

Q

N

R

D

R

R

L

R

K

K

E

K

F

W

V

T

P

A

K

P

Q

A

K

Y

E

K

I

V

K

N

S

R

R

G

W

V

L

L

R

Y

R

K

Y

Y

V

I

R

K

F

N

V

V

T

Q

S

S

A

A

S

S

K

D

G

G

A

C

V

V

L

T

E

D

C100 (≠ G46) binding [2Fe-2S] cluster
C173 (= C119) binding [2Fe-2S] cluster
D174 (= D120) binding Mg(2+)
C245 (= C191) binding [2Fe-2S] cluster
E497 (= E443) binding Mg(2+)

9jpiA The complex structure of dhad with aspterric acid (aa). (see paper)
43% identity, 99% coverage: 3:553/554 of query aligns to 19:569/570 of 9jpiA

query
sites
9jpiA

S

S

D

S

K

R

V

I

K

T

K

E

G

P

V

K

E

S

R

Q

A

G

P

G

H

S

R

Q

A

A

L

I

L

L

R

H

A

G

C

V

G

G

L

L

T

S

D

D

E

D

D

D

M

L

D

L

K

K

P

P

L

Q

I

I

G

G

I

I

A

S

N

S

S

V

Y

W

I

Y

D

E

I

G

I

N

P

T

G
x
C

H

N

V

M

H

H

L

L

R

L

E

K

F

L

V

S

E

E

P

A

I

V

K

K

E

E

E

G

V

V

R

E

K

N

A

A

G

G

G

M

V

V

P

G

I

F

E

R

F

F

N

N

V

T

I

I

G

G

V

V

D

S

D
|
D

G
x
A

I

I

A

S

M

M

G

G

H

T

Y
x
R

G

G

M

M

H
x
C

Y

F

S

S

L

L

P

Q

S

S

R

R

E

D

L

L

I

I

A

A

D

D

S

S

I

I

E

E

T

T

V

V

V

M

E

S

A

A

H

Q

Q

W

L

Y

D

D

A

G

L

N

I

I

C

S

I

I

P

P

N

G

C
|
C

D
|
D

K
|
K

I

N

V

M

P

P

G

G

M

T

L

I

M

M

A

A

A

M

V

G

R

R

L

L

N

N

I

R

P

P

T

G

I

I

F

M

I

V

S

Y

G

G

G

G

P

T

M

I

L

K

A

P

G

G

E

H

L

F

E

Q

G

D

Q

K

K

T

V

Y

D

D

L
x
I

I

V

T

S

V

A

F
|
F

E

Q

G

S

I

Y

G

G

Q

E

L

F

K

V

A

S

G

G

K

S

I

I

D

S

E

D

A

E

K

Q

L

R

K

K

L

T

L

V

E

L

Q

H

T

H

A

S

C

C

P

P

T

G

C

A

G

G

S
x
A

C
|
C

S

G

G

G

M

M

F
x
Y

T
|
T

A

A

N

N

S

T

M

M

N

A

C

S

L

A

T

I

E

E

V

A

L

M

G

G

L

M

G

S

L

L

P

P

G

Y

N

S

G

S

T

S

I

I

P

P

A

A

V

E

D

D

P

P

R

L

R

K

E

L

M

D

L

E

A

C

R

R

Q

L

A

A

A

G

R

K

Q

Y

I

L

M

L

E

E

L

L

L

L

K

K

R

M

D

D

I

L

R

K

P

P

R

R

D

D

I

I

V

I

T

T

V

P

E

K

A

S

L

L

D

R

N

N

A

A

F

M

A

V

V

S

D

V

I

M

A

A

M

L

G

G

G

G

S

S

T

T

N

N

T

A

V

V

L

L

H

H

L

L

L

I

A

A

I

I

A

A

Q

R

E

S

A

V

G

G

I

L

D

E

Y

L

P

T

L

L

E

D

R

D

I

F

D

Q

R

K

I

V

S

S

K

D

A

A

T

V

P

P

T

F

L

L

C

A

K

D

I

L

S

K

P

P

A

S

S

G

H

K

Y

Y

H

V

I

M

Q

E

D

D

L

I

D

H

M

K

V

I

G

G

G

G

I

T

P

P

A

A

L

V

L

L

K

R

E

Y

L

L

I

L

R

E

G

L

N

G

Y

-

L

L

P

M

H

D

P

G

D

D

R

C

P

M

T

T

V

V

S

T

L

G

K

Q

T

T

L

L

R

A

E

Q

I

N

A

L

M

E

S

N

A

V

P

P

D

S

-

L

A

T

D

E

G

G

-

Q

E

E

V

I

I

I

R

R

R

P

I

L

E

S

E

N

P

P

Y

I

S

K

R

E

D

T

G

G

G

H

L

I

A

Q

I

I

L

L

F

R

G

G

N

D

L

L

A

A

P

P

E

D

G

G

A

S

V

V

V

A

K

K

T

I

A

T

G

G

V

-

S

-

E

K

N

E

M

G

L

L

V

Y

F

F

R

S

G

G

K

P

A

A

I

L

C

V

F

F

D

E

S

G

E

E

E

E

E

S

A

M

V

L

E

A

A

A

I

I

L

S

G

A

G

D

R

P

V

M

K

S

-

F

P

K

G

G

H

T

V

V

V

V

V

V

I

I

R

R

Y

G

E

E

G

G

P

P

K

K

G

G

G

G

P

P

G

G

M

M

R

P

E
|
E

M

M

L

L

S

T

P

P

T

T

S

S

A

A

I

I

M

M

G

G

M

A

G

G

L

L

G

G

D

K

K

E

V

C

A

A

L

L

I

L

T

T

D

D

G

G

R

R

F

F

S
|
S

G

G

G

G

T

S

R

H

G

G

A

F

C

V

V

V

G

G

H

H

I

I

S

C

P

P

E

E

A

A

A

Q

A

E

G

G

G

G

P

P

I

I

G

G

V

L

V

I

K

K

D

N

G

G

D

D

E

I

I

I

L

T

I

I

D

D

I

I

P

G

G

A

R

A

R

R

I

I

E

D

L

T

L

Q

I

V

P

S

E

P

E

E

E

E

L

M

Q

N

R

D

R

R

L

R

K

K

E

K

F

W

V

T

P

A

K

P

Q

A

K

Y

E
x
K

I

V

K

N

S

R

R

G

W

V

L

L

R

Y

R

K

Y

Y

V

I

R

K

F

N

V

V

T

Q

S

S

A

A

S

S

K

D

G

G

A

C

V

V

L

T

E

D

binding fe2/s2 (inorganic) cluster: C62 (≠ G46), A95 (≠ G79), C135 (= C119), D136 (= D120), A206 (≠ S190), C207 (= C191)
binding Aspterric Acid: D94 (= D78), R101 (≠ Y85), C104 (≠ H88), D136 (= D120), I173 (≠ L157), F177 (= F161), Y211 (≠ F195), T212 (= T196), E459 (= E443), S485 (= S469), K546 (≠ E530)
binding magnesium ion: D94 (= D78), D136 (= D120), K137 (= K121), E459 (= E443)

8hs0A The mutant structure of dhad v178w (see paper)
43% identity, 99% coverage: 3:553/554 of query aligns to 19:569/570 of 8hs0A

query
sites
8hs0A

S

S

D

S

K

R

V

I

K

T

K

E

G

P

V

K

E

S

R

Q

A

G

P

G

H

S

R

Q

A

A

L

I

L

L

R

H

A

G

C

V

G

G

L

L

T

S

D

D

E

D

D

D

M

L

D

L

K

K

P

P

L

Q

I

I

G

G

I

I

A

S

N

S

S

V

Y

W

I

Y

D

E

I

G

I

N

P

T

G
x
C

H

N

V

M

H

H

L

L

R

L

E

K

F

L

V

S

E

E

P

A

I

V

K

K

E

E

E

G

V

V

R

E

K

N

A

A

G

G

G

M

V

V

P

G

I

F

E

R

F

F

N

N

V

T

I

I

G

G

V

V

D

S

D
|
D

G
x
A

I

I

A

S

M

M

G

G

H

T

Y

R

G

G

M

M

H

C

Y

F

S

S

L

L

P

Q

S

S

R

R

E

D

L

L

I

I

A

A

D

D

S

S

I

I

E

E

T

T

V

V

V

M

E

S

A

A

H

Q

Q

W

L

Y

D

D

A

G

L

N

I

I

C

S

I

I

P

P

N

G

C
|
C

D
|
D

K
|
K

I

N

V

M

P

P

G

G

M

T

L

I

M

M

A

A

A

M

V

G

R

R

L

L

N

N

I

R

P

P

T

G

I

I

F

M

I

V

S

Y

G

G

G

G

P

T

M

I

L

K

A

P

G

G

E

H

L

F

E

Q

G

D

Q

K

K

T

V

Y

D

D

L

I

I

W

T

S

V

A

F

F

E

Q

G

S

I

Y

G

G

Q

E

L

F

K

V

A

S

G

G

K

S

I

I

D

S

E

D

A

E

K

Q

L

R

K

K

L

T

L

V

E

L

Q

H

T

H

A

S

C

C

P

P

T

G

C

A

G

G

S

A

C
|
C

S

G

G

G

M

M

F

Y

T

T

A

A

N

N

S

T

M

M

N

A

C

S

L

A

T

I

E

E

V

A

L

M

G

G

L

M

G

S

L

L

P

P

G

Y

N

S

G

S

T

S

I

I

P

P

A

A

V

E

D

D

P

P

R

L

R

K

E

L

M

D

L

E

A

C

R

R

Q

L

A

A

A

G

R

K

Q

Y

I

L

M

L

E

E

L

L

L

L

K

K

R

M

D

D

I

L

R

K

P

P

R

R

D

D

I

I

V

I

T

T

V

P

E

K

A

S

L

L

D

R

N

N

A

A

F

M

A

V

V

S

D

V

I

M

A

A

M

L

G

G

G

G

S

S

T

T

N
|
N

T

A

V

V

L

L

H
|
H

L

L

L

I

A

A

I

I

A

A

Q

R

E

S

A

V

G

G

I

L

D

E

Y

L

P

T

L

L

E

D

R

D

I

F

D

Q

R

K

I

V

S

S

K

D

A

A

T

V

P

P

T

F

L

L

C

A

K

D

I

L

S

K

P

P

A

S

S

G

H

K

Y

Y

H

V

I

M

Q

E

D

D

L

I

D

H

M

K

V

I

G

G

G

G

I

T

P

P

A

A

L

V

L

L

K

R

E

Y

L

L

I

L

R

E

G

L

N

G

Y

L

L

M

P

-

H

D

P

G

D

D

R

C

P

M

T

T

V

V

S

T

L

G

K

Q

T

T

L

L

R

A

E

Q

I

N

A

L

M

E

S

N

A

V

P

P

D

S

-

L

A

T

D

E

G

G

-

Q

E

E

V

I

I

I

R

R

R

P

I

L

E

S

E

N

P

P

Y

I

S

K

R

E

D

T

G

G

G

H

L

I

A

Q

I

I

L

L

F

R

G

G

N

D

L

L

A

A

P

P

E

D

G

G

A

S

V

V

V

A

K

K

T

I

A

T

G

G

V

-

S

-

E

K

N

E

M

G

L

L

V

Y

F

F

R

S

G

G

K

P

A

A

I

L

C

V

F

F

D

E

S

G

E

E

E

E

E

S

A

M

V

L

E

A

A

A

I

I

L

S

G

A

G

D

R

P

V

M

K

S

-

F

P

K

G

G

H

T

V

V

V

V

V

V

I

I

R

R

Y

G

E

E

G

G

P

P

K

K

G

G

G

G

P

P

G

G

M

M

R

P

E

E

M

M

L

L

S

T

P

P

T

T

S

S

A

A

I

I

M

M

G

G

M

A

G

G

L

L

G

G

D

K

K

E

V

C

A

A

L

L

I

L

T

T

D

D

G

G

R

R

F

F

S

S

G

G

G

G

T

S

R

H

G

G

A

F

C

V

V

V

G

G

H

H

I

I

S

C

P

P

E

E

A

A

A

Q

A

E

G

G

G

G

P

P

I

I

G

G

V

L

V

I

K

K

D

N

G

G

D

D

E

I

I

I

L

T

I

I

D

D

I

I

P

G

G

A

R

A

R

R

I

I

E

D

L

T

L

Q

I

V

P

S

E

P

E

E

E

E

L

M

Q

N

R

D

R

R

L

R

K

K

E

K

F

W

V

T

P

A

K

P

Q

A

K

Y

E

K

I

V

K

N

S

R

R

G

W

V

L

L

R

Y

R

K

Y

Y

V

I

R

K

F

N

V

V

T

Q

S

S

A

A

S

S

K

D

G

G

A

C

V

V

L

T

E

D

binding fe2/s2 (inorganic) cluster: C62 (≠ G46), D94 (= D78), A95 (≠ G79), C135 (= C119), D136 (= D120), C207 (= C191)
binding magnesium ion: D136 (= D120), K137 (= K121), N285 (= N269), H289 (= H273)

8imuA Dihydroxyacid dehydratase (dhad) mutant-v497f (see paper)
41% identity, 99% coverage: 3:553/554 of query aligns to 16:522/523 of 8imuA

query
sites
8imuA

S

S

D

S

K

R

V

I

K

T

K

E

G

P

V

K

E

S

R

Q

A

G

P

G

H

S

R

Q

A

A

L

I

L

L

R

H

A

G

C

V

G

G

L

L

T

S

D

D

E

D

D

D

M

L

D

L

K

K

P

P

L

Q

I

I

G

G

I

I

A

S

N

S

S

V

Y

W

I

Y

D

E

I

G

I
x
N

P

T

G
x
C

H

N

V

M

H

H

L

L

R

L

E

K

F

L

V

S

E

E

P

A

I

V

K

K

E

E

E

G

V

V

R

E

K

N

A

A

G

G

G

M

V

V

P

G

I

F

E

R

F

F

N

N

V

T

I

I

G

G

V

V

D

S

D

D

G

A

I

I

A

S

M

M

G

G

H

T

Y

R

G

G

M

M

H

C

Y

F

S

S

L

L

P

Q

S

S

R

R

E

D

L

L

I

I

A

A

D

D

S

S

I

I

E

E

T

T

V

V

V

M

E

S

A

A

H

Q

Q

W

L

Y

D

D

A

G

L

N

I

I

C

S

I

I

P

P

N

G

C
|
C

D
|
D

K

K

I

N

V

M

P

P

G

G

M

T

L

I

M

M

A

A

A

M

V

G

R

R

L

L

N

N

I

R

P

P

T

G

I

I

F

M

I

V

S

Y

G

G

G

G

P

T

M

I

L

K

A

P

G

G

E

-

L

-

E

-

G

-

Q

-

K

-

V

-

D

-

L

-

I

-

T

-

V

-

F

-

E

-

G

-

I

-

G

-

Q

-

L

-

K

-

A

-

G

-

K

-

I

-

D

-

E

-

A

-

K

-

L

-

K

-

L

-

L

-

E

-

Q

-

T

-

A

-

C

-

P

-

T

-

C

-

G

-

S

-

C

-

S

-

G

G

M

M

F

Y

T

T

A

A

N

N

S

T

M

M

N

A

C

S

L

A

T

I

E

E

V

A

L

M

G

G

L

M

G

S

L

L

P

P

G

Y

N

S

G

S

T

S

I

I

P

P

A

A

V

E

D

D

P

P

R

L

R

K

E

L

M

D

L

E

A

C

R

R

Q

L

A

A

A

G

R

K

Q

Y

I

L

M

L

E

E

L

L

L

L

K

K

R

M

D

D

I

L

R

K

P

P

R

R

D

D

I

I

V

I

T

T

V

P

E

K

A

S

L

L

D

R

N

N

A

A

F

M

A

V

V

S

D

V

I

M

A

A

M

L

G

G

G

G

S

S

T

T

N

N

T

A

V

V

L

L

H

H

L

L

L

I

A

A

I

I

A

A

Q

R

E

S

A

V

G

G

I

L

D

E

Y

L

P

T

L

L

E

D

R

D

I

F

D

Q

R

K

I

V

S

S

K

D

A

A

T

V

P

P

T

F

L

L

C

A

K

D

I

L

S

K

P

P

A

S

S

G

H

K

Y

Y

H

V

I

M

Q

E

D

D

L

I

D

H

M

K

V

I

G

G

G

G

I

T

P

P

A

A

L

V

L

L

K

R

E

Y

L

L

I

L

R

E

G

L

N

G

Y

L

L

M

P

-

H

D

P

G

D

D

R

C

P

M

T

T

V

V

S

T

L

G

K

Q

T

T

L

L

R

A

E

Q

I

N

A

L

M

E

S

N

A

V

P

P

D

S

-

L

A

T

D

E

G

G

-

Q

E

E

V

I

I

I

R

R

R

P

I

L

E

S

E

N

P

P

Y

I

S

K

R

E

D

T

G

G

G

H

L

I

A

Q

I

I

L

L

F

R

G

G

N

D

L

L

A

A

P

P

E

D

G

G

A

S

V

V

V

A

K

K

T

I

A

T

G

G

V

-

S

-

E

K

N

E

M

G

L

L

V

Y

F

F

R

S

G

G

K

P

A

A

I

L

C

V

F

F

D

E

S

G

E

E

E

E

E

S

A

M

V

L

E

A

A

A

I

I

L

S

G

A

G

D

R

P

V

M

K

S

-

F

P

K

G

G

H

T

V

V

V

V

V

V

I

I

R

R

Y

G

E

E

G

G

P

P

K

K

G

G

G

G

P

P

G

G

M

M

R

P

E

E

M

M

L

L

S

T

P

P

T

T

S

S

A

A

I

I

M

M

G

G

M

A

G

G

L

L

G

G

D

K

K

E

V

C

A

A

L

L

I

L

T

T

D

D

G

G

R

R

F

F

S

S

G

G

G

G

T

S

R

H

G

G

A

F

C

V

V

F

G

G

H

H

I

I

S

C

P

P

E

E

A

A

A

Q

A

E

G

G

G

G

P

P

I

I

G

G

V

L

V

I

K

K

D

N

G

G

D

D

E

I

I

I

L

T

I

I

D

D

I

I

P

G

G

A

R

A

R

R

I

I

E

D

L

T

L

Q

I

V

P

S

E

P

E

E

E

E

L

M

Q

N

R

D

R

R

L

R

K

K

E

K

F

W

V

T

P

A

K

P

Q

A

K

Y

E

K

I

V

K

N

S

R

R

G

W

V

L

L

R

Y

R

K

Y

Y

V

I

R

K

F

N

V

V

T

Q

S

S

A

A

S

S

K

D

G

G

A

C

V

V

L

T

E

D

binding fe2/s2 (inorganic) cluster: N57 (≠ I44), C59 (≠ G46), C132 (= C119), D133 (= D120)

9evvD His579leu variant of l-arabinonate dehydratase co-crystallized with 2- oxobutyrate (see paper)
35% identity, 100% coverage: 1:553/554 of query aligns to 7:560/575 of 9evvD

query
sites
9evvD

M

L

R

R

S

S

D

Q

K

E

V

W

K

Y

K

G

G

G

V

T

E

S

R

R

-

D

-

V

A

I

P

Y

H

H

R

R

A

G

L

W

L

L

R

K

A

N

C

Q

G

G

L

Y

T

P

D

H

E

D

D

L

M

F

D

D

-

G

K

R

P

P

L

V

I

I

G

G

I

I

A

L

N

N

S

T

Y

W

I

S

D

D

I

M

I

T

P

P

G
x
C

H

N

V

G

H

H

L

L

R

R

E

E

F

L

V

A

E

E

P

K

I

V

K

K

E

A

E

G

V

V

R

W

K

E

A

A

G

G

G

G

V

F

P

P

I

L

E

E

F

V

N

P

V

V

I

F

G

S

V

A

D

S

D
x
E

G

N

I

T

A

F

M

R

G

P

H

T

Y

A

G

M

M

M

H

Y

Y

-

S

-

L

-

P

-

S

-

R

R

E

N

L

L

I

A

A

A

D

L

S

A

I

V

E

E

T

E

V

A

V

I

E

R

A

G

H

Q

Q

P

L

M

D

D

A

G

L

C

I

V

C

L

I

L

P

V

N

G

C
|
C

D
|
D

K
|
K

I

T

V

T

P

P

G

S

M

L

L

L

M

M

A

G

A

A

V

A

R

S

L

C

N

D

I

L

P

P

T

S

I

I

F

V

I

V

S

T

G

G

G

G

P

P

M

M

L

L

A

N

G

G

E

Y

L

F

E

R

G

G

Q

E

K

R

V

V

D

G

L

S

I

G

T

T

V

H

F

L

E

W

G

K

I

F

G

S

Q

E

L

M

-

V

K

K

A

A

G

G

K

E

I

M

D

T

E

Q

A

A

K

E

L

F

K

L

L

E

L

A

E

E

Q

A

T

S

A

M

C

S

P

R

T

S

C

S

G

G

S
x
T

C
|
C

S

N

G

T

M

M

F

G

T
|
T

A

A

N

S

S

T

M

M

N

A

C

S

L

M

T

A

E

E

V

A

L

L

G

G

L

M

G

A

L

L

P

S

G

G

N

N

G

A

T

A

I

I

P

P

A

G

V

V

D

D

P

S

R

R

R

R

E

K

M

V

L

M

A

A

R

Q

Q

L

A

T

A

G

R

R

Q

R

I

I

M

V

E

Q

L

M

L

V

K

K

R

D

D

D

I

L

R

K

P

P

R

S

D

E

I

I

V

M

T

T

V

K

E

Q

A

A

L

F

D

E

N

N

A

A

F

I

A

R

V

T

D

N

I

A

A

A

M

I

G

G

G

G

S

S

T

T

N

N

T

A

V

V

L

I

H

H

L

L

L

L

A

A

I

I

A

A

Q

G

E

R

A

V

G

G

I

I

D

D

Y

L

P

S

L

L

E

D

R

D

I

W

D

D

R

R

I

C

S

G

K

R

A

D

T

V

P

P

T

T

L

I

C

V

K

N

I

L

S

M

P

P

A

S

S

G

H

K

Y

Y

H

L

I

M

Q

E

D

E

L

F

D

F

M

Y

V

A

G

G

G

G

I

L

P

P

A

V

L

V

L

L

K

K

E

R

L

L

I

G

R

E

G

A

N

G

Y

L

L

L

P

-

H

H

P

K

D

D

R

A

P

L

T

T

V

V

S

S

L

G

K

E

T

T

L

V

R

W

E

D

I

E

A

V

M

K

S

D

A

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P

V

D

N

A

W

D

N

G

E

E

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V

V

I

I

R

L

R

P

I

A

E

E

E

K

P

A

Y

L

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T

R

S

D

S

G

G

G

G

L

I

A

V

I

V

L

L

F

R

G

G

N

N

L

L

A

A

P

P

E

K

G

G

A

A

V

V

V

L

K

K

T

P

A

S

G

A

V

A

S

S

E

P

N

H

M

L

L

L

V

V

F

H

R

K

G

G

K

R

A

A

I

V

C

V

F

F

D

E

S

D

E

I

E

D

E

D

A

Y

V

K

E

A

A

K

I

I

L

N

G

D

G

D

R

N

-

L

-

D

V

I

K

D

P

E

G

N

H

C

V

I

V

M

V

V

I

M

R

K

Y

N

E

C

G

G

P

P

K

K

G

G

G

Y

P

P

G

G

M

M

R

A

E
|
E

M

V

-

G

-

N

L

M

S

G

P

L

T

P

S

P

A

K

I

V

M

L

G

K

M

K

G

G

L

I

G

L

D

D

K

M

V

V

A

R

L

-

I

I

T

S

D

D

G

A

R

R

F

M

S
|
S

G
|
G

G

T

T

A

R

Y

G

G

A

T

C

V

V

V

G

L

H

H

I

T

S

S

P

P

E

E

A

A

A

A

A

V

G

G

G

G

P

P

I

L

G

A

V

V

V

V

K

K

D

N

G

G

D

D

E

M

I

I

L

E

I

L

D

D

I

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P

P

G

N

R

R

R

R

I

L

E

H

L

L

L

D

I

I

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E

E

E

L

L

Q

A

R

R

R

R

L

L

K

A

E

E

F

W

V

Q

P

P

K

N

Q

H

K

D

E

L

I

P

K

T

S

S

R

G

W

Y

L

A

R

F

R

L

Y

H

V

Q

R

Q

F

H

V

V

T

E

S

G

A

A

S

D

K

T

G

G

A

A

V

D

L

L

E

D

binding 2-ketobutyric acid: E87 (≠ D78), D124 (= D120), T201 (= T196), E449 (= E443), S476 (= S469), G477 (= G470)
binding fe2/s2 (inorganic) cluster: C55 (≠ G46), C123 (= C119), D124 (= D120), T195 (≠ S190), C196 (= C191)
binding magnesium ion: E87 (≠ D78), D124 (= D120), K125 (= K121), E449 (= E443)

9evvA His579leu variant of l-arabinonate dehydratase co-crystallized with 2- oxobutyrate (see paper)
35% identity, 100% coverage: 1:553/554 of query aligns to 7:560/575 of 9evvA

query
sites
9evvA

M

L

R

R

S

S

D

Q

K

E

V

W

K

Y

K

G

G

G

V

T

E

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R

R

-

D

-

V

A

I

P

Y

H

H

R

R

A

G

L

W

L

L

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K

A

N

C

Q

G

G

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Y

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P

D

H

E

D

D

L

M

F

D

D

-

G

K

R

P

P

L

V

I

I

G

G

I

I

A

L

N

N

S

T

Y

W

I

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D

D

I

M

I

T

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P

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x
C

H

N

V

G

H

H

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L

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R

E

E

F

L

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A

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E

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K

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A

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K

E

A

A

G

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P

I

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E

E

F

V

N

P

V

V

I

F

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S

V

A

D

S

D
x
E

G
x
N

I

T

A

F

M

R

G

P

H

T

Y

A

G

M

M

M

H

Y

Y

-

S

-

L

-

P

-

S

-

R

R

E

N

L

L

I

A

A

A

D

L

S

A

I

V

E

E

T

E

V

A

V

I

E

R

A

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H

Q

Q

P

L

M

D

D

A

G

L

C

I

V

C

L

I

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N

G

C
|
C

D
|
D

K
|
K

I

T

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T

P

P

G

S

M

L

L

L

M

M

A

G

A

A

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A

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C

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I

F

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I

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T

G

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N

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V

H

F

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L

M

-

V

K

K

A

A

G

G

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Q

A

A

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L

F

K

L

L

E

L

A

E

E

Q

A

T

S

A

M

C

S

P

R

T

S

C

S

G

G

S
x
T

C
|
C

S

N

G

T

M

M

F

G

T

T

A

A

N

S

S

T

M

M

N

A

C

S

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M

T

A

E

E

V

A

L

L

G

G

L

M

G

A

L

L

P

S

G

G

N

N

G

A

T

A

I

I

P

P

A

G

V

V

D

D

P

S

R

R

R

R

E

K

M

V

L

M

A

A

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Q

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Q

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I

I

M

V

E

Q

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M

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V

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K

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D

D

I

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R

K

P

P

R

S

D

E

I

I

V

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T

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Q

A

A

L

F

D

E

N

N

A

A

F

I

A

R

V

T

D

N

I

A

A

A

M

I

G

G

G

G

S

S

T

T

N

N

T

A

V

V

L

I

H

H

L

L

L

L

A

A

I

I

A

A

Q

G

E

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A

V

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G

I

I

D

D

Y

L

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S

L

L

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D

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K

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A

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T

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I

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P

A

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G

H

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Y

Y

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D

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M

Y

V

A

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P

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K

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L

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-

H

H

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T

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W

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N

A

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D

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I

A

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A

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G

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G

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I

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L

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N

N

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L

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G

G

A

A

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V

V

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K

K

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A

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G

A

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A

S

S

E

P

N

H

M

L

L

L

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V

F

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G

G

K

R

A

A

I

V

C

V

F

F

D

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D

E

I

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D

E

D

A

Y

V

K

E

A

A

K

I

I

L

N

G

D

G

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R

N

-

L

-

D

V

I

K

D

P

E

G

N

H

C

V

I

V

M

V

V

I

M

R

K

Y

N

E

C

G

G

P

P

K

K

G

G

G

Y

P

P

G

G

M

M

R

A

E
|
E

M

V

-

G

-

N

L

M

S

G

P

L

T

P

S

P

A

K

I

V

M

L

G

K

M

K

G

G

L

I

G

L

D

D

K

M

V

V

A

R

L

-

I

I

T

S

D

D

G

A

R

R

F

M

S

S

G

G

G

T

T

A

R

Y

G

G

A

T

C

V

V

V

G

L

H

H

I

T

S

S

P

P

E

E

A

A

A

A

A

V

G

G

G

G

P

P

I

L

G

A

V

V

V

V

K

K

D

N

G

G

D

D

E

M

I

I

L

E

I

L

D

D

I

V

P

P

G

N

R

R

R

R

I

L

E

H

L

L

L

D

I

I

P

S

E

D

E

E

E

E

L

L

Q

A

R

R

R

R

L

L

K

A

E

E

F

W

V

Q

P

P

K

N

Q

H

K

D

E

L

I

P

K

T

S

S

R

G

W

Y

L

A

R

F

R

L

Y

H

V

Q

R

Q

F

H

V

V

T

E

S

G

A

A

S

D

K

T

G

G

A

A

V

D

L

L

E

D

binding fe2/s2 (inorganic) cluster: C55 (≠ G46), N88 (≠ G79), C123 (= C119), D124 (= D120), T195 (≠ S190), C196 (= C191)
binding magnesium ion: E87 (≠ D78), D124 (= D120), K125 (= K121), E449 (= E443)

B5ZZ34 L-arabinonate dehydratase; ArDHT; D-fuconate dehydratase; Galactonate dehydratase; L-arabonate dehydratase; EC 4.2.1.25; EC 4.2.1.67; EC 4.2.1.6 from Rhizobium leguminosarum bv. trifolii (strain WSM2304) (see 2 papers)
35% identity, 100% coverage: 1:553/554 of query aligns to 11:564/579 of B5ZZ34

query
sites
B5ZZ34

M

L

R

R

S

S

D

Q

K

E

V

W

K

Y

K

G

G

G

V

T

E

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R

-

D

-

V

A

I

P

Y

H

H

R

R

A

G

L

W

L

L

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K

A

N

C

Q

G

G

L

Y

T

P

D

H

E

D

D

L

M

F

D

D

-

G

K

R

P

P

L

V

I

I

G

G

I

I

A

L

N

N

S

T

Y

W

I

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D

D

I

M

I

T

P

P

G
x
C

H

N

V

G

H

H

L

L

R

R

E

E

F

L

V

A

E

E

P

K

I

V

K

K

E

A

E

G

V

V

R

W

K

E

A

A

G

G

G

G

V

F

P

P

I

L

E

E

F

V

N

P

V

V

I

F

G

S

V

A

D

S

D
x
E

G

N

I

T

A

F

M

R

G

P

H

T

Y

A

G

M

M

M

H

Y

Y

-

S

-

L

-

P

-

S

-

R

R

E

N

L

L

I

A

A

A

D

L

S

A

I

V

E

E

T

E

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A

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M

D

D

A

G

L

C

I

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C

L

I

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C
|
C

D
|
D

K

K

I

T

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T

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P

G

S

M

L

L

L

M

M

A

G

A

A

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A

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I

I

F

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I

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T

G

G

G

G

P

P

M

M

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L

A

N

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G

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Y

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G

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V

H

F

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E

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G

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E

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M

-

V

K

K

A

A

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G

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E

I

M

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Q

A

A

K

E

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F

K

L

L

E

L

A

E

E

Q

A

T

S

A

M

C

S

P

R

T

S

C

S

G

G

S

T

C
|
C

S

N

G