SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing WP_012992620.1 NCBI__GCF_000025605.1:WP_012992620.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

3ea4A Arabidopsis thaliana acetohydroxyacid synthase in complex with monosulfuron-ester (see paper)
51% identity, 98% coverage: 3:572/584 of query aligns to 11:581/582 of 3ea4A

query
sites
3ea4A

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active site: Y32 (≠ H24), G34 (= G26), G35 (= G27), A36 (= A28), S37 (≠ I29), E58 (= E50), T81 (= T73), F120 (= F112), Q121 (= Q113), E122 (= E114), K170 (= K162), M265 (= M261), V292 (= V288), V399 (= V397), G425 (= G423), M427 (= M425), D452 (= D450), N479 (= N477), H481 (≠ Y479), L482 (= L480), M484 (= M482), V485 (= V483), W488 (= W486), H557 (≠ R549)
binding methyl 2-{[(4-methylpyrimidin-2-yl)carbamoyl]sulfamoyl}benzoate: D290 (= D286), R291 (= R287), W488 (= W486), S567 (≠ A559)
binding flavin-adenine dinucleotide-n5-isobutyl ketone: R160 (= R152), G221 (= G215), G222 (= G216), G223 (= G217), T245 (= T241), L246 (≠ N242), M247 (= M243), L263 (= L259), G264 (= G260), M265 (= M261), H266 (= H262), G285 (= G281), R287 (= R283), D289 (= D285), R291 (= R287), D309 (= D305), I310 (= I306), G327 (= G323), D328 (= D324), V329 (= V325), M404 (= M402), G422 (= G420)
binding magnesium ion: D452 (= D450), N479 (= N477), H481 (≠ Y479)
binding 2-[(2e)-3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-(1-hydroxyethylidene)-4-methyl-2,3-dihydro-1,3-thiazol-5-yl]ethyltrihydrogen diphosphate: V399 (= V397), G400 (= G398), Q401 (= Q399), H402 (= H400), M427 (= M425), G451 (= G449), D452 (= D450), G453 (= G451), S454 (= S452), N479 (= N477), H481 (≠ Y479), L482 (= L480), G483 (= G481), M484 (= M482), V485 (= V483)

3e9yA Arabidopsis thaliana acetohydroxyacid synthase in complex with monosulfuron (see paper)
51% identity, 98% coverage: 3:572/584 of query aligns to 11:581/582 of 3e9yA

query
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3e9yA

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active site: Y32 (≠ H24), G34 (= G26), G35 (= G27), A36 (= A28), S37 (≠ I29), E58 (= E50), T81 (= T73), F120 (= F112), Q121 (= Q113), E122 (= E114), K170 (= K162), M265 (= M261), V292 (= V288), V399 (= V397), G425 (= G423), M427 (= M425), D452 (= D450), N479 (= N477), H481 (≠ Y479), L482 (= L480), M484 (= M482), V485 (= V483), W488 (= W486), H557 (≠ R549)
binding N-[(4-methylpyrimidin-2-yl)carbamoyl]-2-nitrobenzenesulfonamide: D290 (= D286), R291 (= R287), W488 (= W486), S567 (≠ A559)
binding flavin-adenine dinucleotide-n5-isobutyl ketone: R160 (= R152), G221 (= G215), G222 (= G216), G223 (= G217), T245 (= T241), L246 (≠ N242), M247 (= M243), L263 (= L259), G285 (= G281), R287 (= R283), D289 (= D285), R291 (= R287), D309 (= D305), I310 (= I306), G327 (= G323), D328 (= D324), V329 (= V325), M404 (= M402), G422 (= G420)
binding magnesium ion: D452 (= D450), N479 (= N477), H481 (≠ Y479)
binding 2-[(2e)-3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-(1-hydroxyethylidene)-4-methyl-2,3-dihydro-1,3-thiazol-5-yl]ethyltrihydrogen diphosphate: V399 (= V397), G400 (= G398), Q401 (= Q399), H402 (= H400), M427 (= M425), G451 (= G449), G453 (= G451), S454 (= S452), N479 (= N477), H481 (≠ Y479), L482 (= L480), G483 (= G481), M484 (= M482), V485 (= V483)

9c4rA Acetolactate synthase, chloroplastic (see paper)
50% identity, 98% coverage: 3:572/584 of query aligns to 12:582/582 of 9c4rA

query
sites
9c4rA

R

R

K

K

G

G

A

A

D

D

I

I

V

L

I

V

E

E

V

A

L

L

K

E

E

R

E

Q

G

G

V

V

E

E

V

T

I

V

F

F

G

A

H

Y

P

P

G

G

A

A

I

S

M

M

E

E

V

I

Y

H

D

Q

A

A

L

L

Y

T

R

R

D

S

G

S

I

I

R

R

H

N

I

V

L

L

A

P

R

R

H

H

E

E

Q

Q

G

G

A

G

G

V

H

F

M

A

A

A

E

E

G

G

Y

Y

A

A

K

R

A

S

T

S

G

G

K

K

V

P

G

G

V

I

A

C

M

I

A

A

T

T

S

S

G

G

P

P

G

G

A

A

T

T

N

N

L

L

V

V

T

S

A

G

I

L

A

A

D

D

A

A

Y

L

M

L

D

D

S

S

V

V

P

P

V

L

V

V

F

A

I

I

T

T

G

G

Q

Q

V

V

P

P

T

R

H

R

L

M

I

I

G

G

N

T

D

D

A

A

F

F

Q

Q

E

E

V

T

D

P

I

I

V

V

G

E

I

V

T

T

R

R

P

S

I

I

T

T

K

K

H

H

N

N

F

Y

L

L

V

V

K

M

R

D

I

V

E

E

D

D

L

I

P

P

L

R

I

I

L

I

R

E

Q

E

A

A

F

F

Y

F

I

L

A

A

R

T

T

S

G

G

R
|
R

P

P

G

G

P

P

V

V

L

L

V

V

D

D

I

V

P

P

K

K

D

D

I

I

T

Q

Q

Q

K

Q

L

L

S

A

D

-

V

-

G

-

I

I

P

P

T

N

L

W

E

E

E

Q

V

A

K

M

E

R

S

-

L

L

P

P

G

G

Y

Y

K

M

P

S

H

R

V

M

E

P

G

K

N

P

P

P

Q

E

-

D

-

S

Q

H

I

L

K

E

K

Q

A

I

V

V

K

R

L

L

I

I

M

S

E

E

A

S

K

K

R

K

P

P

V

V

L

L

Y

Y

V

V

G
|
G

A

C

V

L

Q

N

S

S

E

-

A

-

Q

S

K

D

E

E

L

L

V

G

E

R

L

F

A

V

E

E

M

L

M

T

K

G

I

I

P

P

V

V

T

A

T

S

T
|
T

N
x
L

M
|
M

G

G

K

L

G

G

A

S

F

Y

P

P

E

C

N

D

H

D

P

E

L

L

A

S

L

L

H

H

M

M

L
|
L

G

G

M
|
M

H
|
H

G

G

T

T

Y

V

Y

Y

A

A

N

N

M

Y

A

A

V

V

Y

E

H

H

C

S

D

D

L

L

I

L

A

A

V

F

G
|
G

A
x
V

R
|
R

F

F

D
|
D

D

D

R
|
R

V
|
V

T

T

G

G

K

K

V

L

E

E

E

A

F

F

A

A

P

S

R

R

A

A

K

K

I

I

I

V

H

H

I

I

D
|
D

I
|
I

D

D

P

S

A

A

S

E

I

I

S

G

K

K

N

N

I

K

V

T

V

P

D

H

V

V

P

S

I

V

V

C

G

G

D
|
D

V
|
V

K

K

V

L

V

A

L

L

R

Q

-

G

-

M

-

N

K

K

I

V

L

L

E

E

D

N

L

-

R

R

K

A

E

E

G

E

A

L

R

K

I

L

L

D

F

F

P

-

E

-

R

-

Q

G

K

V

W

W

L

R

E

N

Q

E

I

L

E

N

K

V

W

Q

K

K

K

Q

L

K

H

F

P

P

L

L

T

S

Y

F

K

K

K

T

S

F

D

G

K

E

V

A

I

I

K

P

P

P

Q

Q

F

Y

V

A

I

I

E

K

Q

V

I

L

Y

D

E

E

A

L

T

T

R

D

G

G

D

K

A

A

I

I

C

S

T

T

G

G

V
|
V

G
|
G

Q
|
Q

H
|
H

Q

Q

M
|
M

W

W

A

A

M

Q

F

F

Y

Y

R

N

Y

Y

S

K

Y

K

P

P

R

R

Q

Q

F

W

I

L

N

S

S

S

G
|
G

G

G

L

L

G
|
G

T

A

M
|
M

G

G

F

F

G

G

F

L

P

P

A

A

G

A

I

I

G

G

A

A

K

S

I

V

G

A

R

N

P

P

D

D

K

A

E

I

V

V

F

V

V

D

I

I

D

D

G
|
G

D
|
D

G
|
G

S
|
S

F

F

M

I

M
|
M

T

N

M

V

Q

Q

E

E

L

L

V

A

T

T

A

I

V

R

Q

V

Y

E

K

N

V

L

P

P

V

V

K

K

V

V

A

L

I

L

N

N

N
|
N

S

Q

Y
x
H

L
|
L

G
|
G

M
|
M

V
|
V

R

M

Q

Q

W
|
W

Q

E

E

D

L

R

F

F

Y

Y

E

K

K

A

R

N

Y

R

S

A

E

H

V

T

D

F

L

L

S

G

-

D

-

P

-

A

-

Q

-

E

-

D

-

E

V

I

Q

F

P

P

D

N

F

M

V

L

K

L

L

F

A

A

E

A

A

A

C

C

G

G

A

I

V

P

G

A

F

A

R

R

A

V

E

T

K

K

P

K

S

A

D

D

V

L

R

R

E

E

I

A

I

I

E

Q

E

T

A

M

L

L

R

D

I

T

D

P

D

G

R

-

P

P

V

Y

I

L

M

L

D

D

F

V

H

I

V

C

D

P

R

H

E

Q

E

E

N

H

V

V

L

L

P

P

M

M

V

I

P

P

A
x
S

G

G

K

G

S

T

Y

F

R

N

D

D

M

V

I

I

L

T

D

E

-

G

D

D

G

G

K

R

binding 2-(2-chloroethoxy)-N-[(4-methoxy-6-methylpyrimidin-2-yl)carbamoyl]benzene-1-sulfonamide: M266 (= M261), R292 (= R287), W489 (= W486), S568 (≠ A559)
binding 2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-2-[(1~{S})-1-(dioxidanyl)-1-oxidanyl-ethyl]-4-methyl-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate: V400 (= V397), G401 (= G398), Q402 (= Q399), H403 (= H400), G426 (= G423), M428 (= M425), G452 (= G449), G454 (= G451), S455 (= S452), M458 (= M455), N480 (= N477), H482 (≠ Y479), L483 (= L480), G484 (= G481), M485 (= M482), V486 (= V483)
binding flavin-adenine dinucleotide: R161 (= R152), G222 (= G215), G223 (= G216), G224 (= G217), T246 (= T241), L247 (≠ N242), M248 (= M243), L264 (= L259), M266 (= M261), H267 (= H262), G286 (= G281), V287 (≠ A282), R288 (= R283), D290 (= D285), V293 (= V288), D310 (= D305), I311 (= I306), D329 (= D324), V330 (= V325), M405 (= M402), G423 (= G420)
binding magnesium ion: D453 (= D450), N480 (= N477), H482 (≠ Y479)

9c4qA Acetolactate synthase, chloroplastic (see paper)
50% identity, 98% coverage: 3:572/584 of query aligns to 12:582/582 of 9c4qA

query
sites
9c4qA

R

R

K

K

G

G

A

A

D

D

I

I

V

L

I

V

E

E

V

A

L

L

K

E

E

R

E

Q

G

G

V

V

E

E

V

T

I

V

F

F

G

A

H

Y

P

P

G

G

A

A

I

S

M

M

E

E

V

I

Y

H

D

Q

A

A

L

L

Y

T

R

R

D

S

G

S

I

I

R

R

H

N

I

V

L

L

A

P

R

R

H

H

E

E

Q

Q

G

G

A

G

G

V

H

F

M

A

A

A

E

E

G

G

Y

Y

A

A

K

R

A

S

T

S

G

G

K

K

V

P

G

G

V

I

A

C

M

I

A

A

T

T

S

S

G

G

P

P

G

G

A

A

T

T

N

N

L

L

V

V

T

S

A

G

I

L

A

A

D

D

A

A

Y

L

M

L

D

D

S

S

V

V

P

P

V

L

V

V

F

A

I

I

T

T

G

G

Q

Q

V

V

P

P

T

R

H

R

L

M

I

I

G

G

N

T

D

D

A

A

F

F

Q

Q

E

E

V

T

D

P

I

I

V

V

G

E

I

V

T

T

R

R

P

S

I

I

T

T

K

K

H

H

N

N

F

Y

L

L

V

V

K

M

R

D

I

V

E

E

D

D

L

I

P

P

L

R

I

I

L

I

R

E

Q

E

A

A

F

F

Y

F

I

L

A

A

R

T

T

S

G

G

R
|
R

P

P

G

G

P

P

V

V

L

L

V

V

D

D

I

V

P

P

K

K

D

D

I

I

T

Q

Q

Q

K

Q

L

L

S

A

D

-

V

-

G

-

I

I

P

P

T

N

L

W

E

E

E

Q

V

A

K

M

E

R

S

-

L

L

P

P

G

G

Y

Y

K

M

P

S

H

R

V

M

E

P

G

K

N

P

P

P

Q

E

-

D

-

S

Q

H

I

L

K

E

K

Q

A

I

V

V

K

R

L

L

I

I

M

S

E

E

A

S

K

K

R

K

P

P

V

V

L

L

Y

Y

V

V

G
|
G

A

C

V

L

Q

N

S

S

E

-

A

-

Q

S

K

D

E

E

L

L

V

G

E

R

L

F

A

V

E

E

M

L

M

T

K

G

I

I

P

P

V

V

T

A

T

S

T
|
T

N
x
L

M
|
M

G

G

K

L

G

G

A

S

F

Y

P

P

E

C

N

D

H

D

P

E

L

L

A

S

L

L

H

H

M
|
M

L
|
L

G

G

M
|
M

H
|
H

G

G

T

T

Y

V

Y

Y

A

A

N

N

M

Y

A

A

V

V

Y

E

H

H

C

S

D

D

L

L

I

L

A

A

V

F

G
|
G

A
x
V

R
|
R

F

F

D
|
D

R
|
R

V
|
V

T

T

G

G

K

K

V

L

E

E

E

A

F

F

A

A

P

S

R

R

A

A

K

K

I

I

I

V

H

H

I

I

D
|
D

I
|
I

D

D

P

S

A

A

S

E

I

I

S

G

K

K

N

N

I

K

V

T

V

P

D

H

V

V

P

S

I

V

V

C

G

G

D
|
D

V
|
V

K

K

V

L

V

A

L

L

R

Q

-

G

-

M

-

N

K

K

I

V

L

L

E

E

D

N

L

-

R

R

K

A

E

E

G

E

A

L

R

K

I

L

L

D

F

F

P

-

E

-

R

-

Q

G

K

V

W

W

L

R

E

N

Q

E

I

L

E

N

K

V

W

Q

K

K

K

Q

L

K

H

F

P

P

L

L

T

S

Y

F

K

K

K

T

S

F

D

G

K

E

V

A

I

I

K

P

P

P

Q

Q

F
x
Y

V

A

I

I

E

K

Q

V

I

L

Y

D

E

E

A

L

T

T

R

D

G

G

D

K

A

A

I

I

C

S

T

T

G

G

V
|
V

G
|
G

Q
|
Q

H
|
H

Q

Q

M
|
M

W

W

A

A

M

Q

F

F

Y

Y

R

N

Y

Y

S

K

Y

K

P

P

R

R

Q

Q

F

W

I

L

N

S

S

S

G
|
G

G

G

L

L

G
|
G

T

A

M
|
M

G

G

F

F

G

G

F

L

P

P

A

A

G

A

I

I

G

G

A

A

K

S

I

V

G

A

R

N

P

P

D

D

K

A

E

I

V

V

F

V

V

D

I

I

D

D

G
|
G

D
|
D

G
|
G

S
|
S

F

F

M

I

M
|
M

T

N

M

V

Q
|
Q

E

E

L

L

V

A

T

T

A

I

V

R

Q

V

Y

E

K

N

V

L

P

P

V

V

K

K

V

V

A

L

I

L

N

N

N
|
N

S

Q

Y
x
H

L
|
L

G
|
G

M
|
M

V
|
V

R

M

Q

Q

W
|
W

Q

E

E

D

L

R

F

F

Y

Y

E

K

K

A

R

N

Y

R

S

A

E

H

V

T

D

F

L

L

S

G

-

D

-

P

-

A

-

Q

-

E

-

D

-

E

V

I

Q

F

P

P

D

N

F

M

V

L

K

L

L

F

A

A

E

A

A

A

C

C

G

G

A

I

V

P

G

A

F

A

R

R

A

V

E

T

K

K

P
x
K

S

A

D

D

V

L

R

R

E

E

I

A

I

I

E

Q

E

T

A

M

L

L

R

D

I

T

D

P

D

G

R

-

P

P

V

Y

I

L

M

L

D

D

F

V

H

I

V

C

D

P

R

H

E

Q

E

E

N

H

V

V

L

L

P

P

M

M

V

I

P

P

A
x
S

G

G

K

G

S

T

Y

F

R

N

D

D

M

V

I

I

L

T

D

E

-

G

D

D

G

G

K

R

binding 2-(2-fluoroethoxy)-N-[(4-methoxy-6-methylpyrimidin-2-yl)carbamoyl]benzene-1-sulfonamide: M266 (= M261), D291 (= D286), R292 (= R287), W489 (= W486), S568 (≠ A559)
binding 2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-2-[(1~{S})-1-(dioxidanyl)-1-oxidanyl-ethyl]-4-methyl-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate: V400 (= V397), G401 (= G398), Q402 (= Q399), H403 (= H400), G426 (= G423), M428 (= M425), G452 (= G449), D453 (= D450), G454 (= G451), S455 (= S452), N480 (= N477), H482 (≠ Y479), L483 (= L480), G484 (= G481), M485 (= M482), V486 (= V483)
binding flavin-adenine dinucleotide: R161 (= R152), G222 (= G215), G223 (= G216), G224 (= G217), T246 (= T241), L247 (≠ N242), M248 (= M243), M263 (= M258), L264 (= L259), M266 (= M261), H267 (= H262), G286 (= G281), V287 (≠ A282), R288 (= R283), D290 (= D285), R292 (= R287), V293 (= V288), D310 (= D305), I311 (= I306), D329 (= D324), V330 (= V325), M405 (= M402), G423 (= G420)
binding magnesium ion: Y381 (≠ F378), D453 (= D450), N480 (= N477), H482 (≠ Y479), K533 (≠ P523)
binding oxygen molecule: M458 (= M455), Q461 (= Q458)

9c4pA Acetolactate synthase, chloroplastic (see paper)
50% identity, 98% coverage: 3:572/584 of query aligns to 12:582/582 of 9c4pA

query
sites
9c4pA

R

R

K

K

G

G

A

A

D

D

I

I

V

L

I

V

E

E

V

A

L

L

K

E

E

R

E

Q

G

G

V

V

E

E

V

T

I

V

F

F

G

A

H

Y

P

P

G

G

A

A

I

S

M

M

E

E

V

I

Y

H

D

Q

A

A

L

L

Y

T

R

R

D

S

G

S

I

I

R

R

H

N

I

V

L

L

A

P

R

R

H

H

E

E

Q

Q

G

G

A

G

G

V

H

F

M

A

A

A

E

E

G

G

Y

Y

A

A

K

R

A

S

T

S

G

G

K

K

V

P

G

G

V

I

A

C

M

I

A

A

T

T

S

S

G

G

P

P

G

G

A

A

T

T

N

N

L

L

V

V

T

S

A

G

I

L

A

A

D

D

A

A

Y

L

M

L

D

D

S

S

V

V

P

P

V

L

V

V

F

A

I

I

T

T

G

G

Q

Q

V

V

P

P

T

R

H

R

L

M

I

I

G

G

N

T

D

D

A

A

F

F

Q

Q

E

E

V

T

D

P

I

I

V

V

G

E

I

V

T

T

R

R

P

S

I

I

T

T

K

K

H

H

N

N

F

Y

L

L

V

V

K

M

R

D

I

V

E

E

D

D

L

I

P

P

L

R

I

I

L

I

R

E

Q

E

A

A

F

F

Y

F

I

L

A

A

R

T

T

S

G

G

R
|
R

P

P

G

G

P

P

V

V

L

L

V

V

D

D

I

V

P

P

K

K

D

D

I

I

T

Q

Q

Q

K

Q

L

L

S

A

D

-

V

-

G

-

I

I

P

P

T

N

L

W

E

E

E

Q

V

A

K

M

E

R

S

-

L

L

P

P

G

G

Y

Y

K

M

P

S

H

R

V

M

E

P

G

K

N

P

P

P

Q

E

-

D

-

S

Q

H

I

L

K

E

K

Q

A

I

V

V

K

R

L

L

I

I

M

S

E

E

A

S

K

K

R

K

P

P

V

V

L

L

Y

Y

V

V

G
|
G

A

C

V

L

Q

N

S

S

E

-

A

-

Q

S

K

D

E

E

L

L

V

G

E

R

L

F

A

V

E

E

M

L

M

T

K

G

I

I

P

P

V

V

T

A

T

S

T
|
T

N
x
L

M
|
M

G

G

K

L

G

G

A

S

F

Y

P

P

E

C

N

D

H

D

P

E

L

L

A

S

L

L

H

H

M
|
M

L
|
L

G

G

M
|
M

H
|
H

G

G

T

T

Y

V

Y

Y

A

A

N

N

M

Y

A

A

V

V

Y

E

H

H

C

S

D

D

L

L

I

L

A

A

V

F

G
|
G

A
x
V

R
|
R

F

F

D
|
D

R
|
R

V
|
V

T

T

G

G

K

K

V

L

E

E

E

A

F

F

A

A

P

S

R

R

A

A

K

K

I

I

I

V

H

H

I

I

D
|
D

I
|
I

D

D

P

S

A

A

S

E

I

I

S

G

K

K

N

N

I

K

V

T

V

P

D

H

V

V

P

S

I

V

V

C

G

G

D
|
D

V
|
V

K

K

V

L

V

A

L

L

R

Q

-

G

-

M

-

N

K

K

I

V

L

L

E

E

D

N

L

-

R

R

K

A

E

E

G

E

A

L

R

K

I

L

L

D

F

F

P

-

E

-

R

-

Q

G

K

V

W

W

L

R

E

N

Q

E

I

L

E

N

K

V

W

Q

K

K

K

Q

L

K

H

F

P

P

L

L

T

S

Y

F

K

K

K

T

S

F

D

G

K

E

V

A

I

I

K

P

P

P

Q

Q

F

Y

V

A

I

I

E

K

Q

V

I

L

Y

D

E

E

A

L

T

T

R

D

G

G

D

K

A

A

I

I

C

S

T

T

G

G

V
|
V

G
|
G

Q
|
Q

H
|
H

Q

Q

M
|
M

W

W

A

A

M

Q

F

F

Y

Y

R

N

Y

Y

S

K

Y

K

P

P

R

R

Q

Q

F

W

I

L

N

S

S

S

G
|
G

L

L

G
|
G

T

A

M
|
M

G

G

F

F

G

G

F

L

P

P

A

A

G

A

I

I

G

G

A

A

K

S

I

V

G

A

R

N

P

P

D

D

K

A

E

I

V

V

F

V

V

D

I

I

D

D

G
|
G

D
|
D

G
|
G

S
|
S

F

F

M

I

M
|
M

T

N

M

V

Q

Q

E

E

L

L

V

A

T

T

A

I

V

R

Q

V

Y

E

K

N

V

L

P

P

V

V

K

K

V

V

A

L

I

L

N

N

N
|
N

S

Q

Y
x
H

L
|
L

G
|
G

M
|
M

V
|
V

R

M

Q

Q

W
|
W

Q

E

E

D

L

R

F

F

Y

Y

E

K

K

A

R

N

Y

R

S

A

E

H

V

T

D

F

L

L

S

G

-

D

-

P

-

A

-

Q

-

E

-

D

-

E

V

I

Q

F

P

P

D

N

F

M

V

L

K

L

L

F

A

A

E

A

A

A

C

C

G

G

A

I

V

P

G

A

F

A

R

R

A

V

E

T

K

K

P

K

S

A

D

D

V

L

R

R

E

E

I

A

I

I

E

Q

E

T

A

M

L

L

R

D

I

T

D

P

D

G

R

-

P

P

V

Y

I

L

M

L

D

D

F

V

H

I

V

C

D

P

R

H

E

Q

E

E

N

H

V

V

L

L

P

P

M

M

V

I

P

P

A
x
S

G

G

K

G

S

T

Y

F

R

N

D

D

M

V

I

I

L

T

D

E

-

G

D

D

G

G

K

R

binding 2-(2-chloroethoxy)-N-[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)carbamoyl]benzene-1-sulfonamide: M266 (= M261), D291 (= D286), R292 (= R287), M485 (= M482), W489 (= W486), S568 (≠ A559)
binding 2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-2-[(1~{S})-1-(dioxidanyl)-1-oxidanyl-ethyl]-4-methyl-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate: V400 (= V397), G401 (= G398), Q402 (= Q399), H403 (= H400), G426 (= G423), M428 (= M425), G452 (= G449), D453 (= D450), G454 (= G451), S455 (= S452), M458 (= M455), N480 (= N477), H482 (≠ Y479), L483 (= L480), G484 (= G481), M485 (= M482), V486 (= V483)
binding flavin-adenine dinucleotide: R161 (= R152), G222 (= G215), G223 (= G216), G224 (= G217), T246 (= T241), L247 (≠ N242), M248 (= M243), M263 (= M258), L264 (= L259), M266 (= M261), H267 (= H262), G286 (= G281), V287 (≠ A282), R288 (= R283), D290 (= D285), R292 (= R287), V293 (= V288), D310 (= D305), I311 (= I306), D329 (= D324), V330 (= V325), M405 (= M402), G423 (= G420), G424 (= G421)
binding magnesium ion: D453 (= D450), N480 (= N477), H482 (≠ Y479)

8et4A Crystal structure of wild-type arabidopsis thaliana acetohydroxyacid synthase in complex with amidosulfuron (see paper)
50% identity, 98% coverage: 3:572/584 of query aligns to 12:582/582 of 8et4A

query
sites
8et4A

R

R

K

K

G

G

A

A

D

D

I

I

V

L

I

V

E

E

V

A

L

L

K

E

E

R

E

Q

G

G

V

V

E

E

V

T

I

V

F

F

G

A

H

Y

P

P

G

G

A

A

I

S

M

M

E

E

V

I

Y

H

D

Q

A

A

L

L

Y

T

R

R

D

S

G

S

I

I

R

R

H

N

I

V

L

L

A

P

R

R

H

H

E

E

Q

Q

G

G

A

G

G

V

H

F

M

A

A

A

E

E

G

G

Y

Y

A

A

K

R

A

S

T

S

G

G

K

K

V

P

G

G

V

I

A

C

M

I

A

A

T

T

S

S

G

G

P

P

G

G

A

A

T

T

N

N

L

L

V

V

T

S

A

G

I

L

A

A

D

D

A

A

Y

L

M

L

D

D

S

S

V

V

P

P

V

L

V

V

F

A

I

I

T

T

G

G

Q

Q

V

V

P

P

T

R

H

R

L

M

I

I

G

G

N

T

D

D

A

A

F

F

Q

Q

E

E

V

T

D

P

I

I

V

V

G

E

I

V

T

T

R

R

P

S

I

I

T

T

K

K

H

H

N

N

F

Y

L

L

V

V

K

M

R

D

I

V

E

E

D

D

L

I

P

P

L

R

I

I

L

I

R

E

Q

E

A

A

F

F

Y

F

I

L

A

A

R

T

T

S

G

G

R
|
R

P

P

G

G

P

P

V

V

L

L

V

V

D

D

I

V

P

P

K

K

D

D

I

I

T

Q

Q

Q

K

Q

L

L

S

A

D

-

V

-

G

-

I

I

P

P

T

N

L

W

E

E

E

Q

V

A

K

M

E

R

S

-

L

L

P

P

G

G

Y

Y

K

M

P

S

H

R

V

M

E

P

G

K

N

P

P

P

Q

E

-

D

-

S

Q

H

I

L

K

E

K

Q

A

I

V

V

K

R

L

L

I

I

M

S

E

E

A

S

K

K

R

K

P

P

V

V

L

L

Y

Y

V

V

G
|
G

A

C

V

L

Q

N

S

S

E

-

A

-

Q

S

K

D

E

E

L

L

V

G

E

R

L

F

A

V

E

E

M

L

M

T

K

G

I

I

P

P

V

V

T

A

T

S

T
|
T

N
x
L

M
|
M

G

G

K

L

G

G

A

S

F

Y

P

P

E

C

N

D

H

D

P

E

L

L

A

S

L

L

H

H

M

M

L
|
L

G

G

M
|
M

H
|
H

G

G

T

T

Y

V

Y

Y

A

A

N

N

M

Y

A

A

V

V

Y

E

H

H

C

S

D

D

L

L

I

L

A

A

V

F

G
|
G

A
x
V

R
|
R

F

F

D
|
D

D

D

R
|
R

V
|
V

T

T

G

G

K

K

V

L

E

E

E

A

F

F

A

A

P

S

R

R

A

A

K

K

I

I

I

V

H

H

I

I

D
|
D

I
|
I

D

D

P

S

A

A

S

E

I

I

S

G

K

K

N

N

I

K

V

T

V

P

D

H

V

V

P

S

I

V

V

C

G

G

D
|
D

V
|
V

K

K

V

L

V

A

L

L

R

Q

-

G

-

M

-

N

K

K

I

V

L

L

E

E

D

N

L

-

R

R

K

A

E

E

G

E

A

L

R

K

I

L

L

D

F

F

P

-

E

-

R

-

Q

G

K

V

W

W

L

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N

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I

L

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N

K

V

W

Q

K

K

K

Q

L

K

H

F

P

P

L

L

T

S

Y
x
F

K

K

K

T

S

F

D

G

K

E

V

A

I

I

K

P

P

P

Q

Q

F

Y

V

A

I

I

E

K

Q

V

I

L

Y

D

E

E

A

L

T

T

R

D

G

G

D

K

A

A

I

I

C

S

T

T

G

G

V
|
V

G
|
G

Q
|
Q

H
|
H

Q

Q

M
|
M

W

W

A

A

M

Q

F

F

Y

Y

R

N

Y

Y

S

K

Y

K

P

P

R

R

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Q

F

W

I

L

N

S

S

S

G
|
G

G

G

L

L

G
|
G

T

A

M
|
M

G

G

F

F

G

G

F

L

P

P

A

A

G

A

I

I

G

G

A

A

K

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I

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P

D

D

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V

F

V

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D

I

I

D

D

G
|
G

D
|
D

G
|
G

S
|
S

F

F

M

I

M
|
M

T

N

M

V

Q
|
Q

E

E

L

L

V

A

T

T

A

I

V

R

Q

V

Y

E

K

N

V

L

P

P

V

V

K

K

V

V

A

L

I

L

N

N

N
|
N

S

Q

Y
x
H

L
|
L

G
|
G

M
|
M

V
|
V

R

M

Q

Q

W
|
W

Q

E

E

D

L

R

F

F

Y

Y

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K

K

A

R

N

Y

R

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A

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H

V

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F

L

L

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G

-

D

-

P

-

A

-

Q

-

E

-

D

-

E

V

I

Q

F

P

P

D

N

F

M

V

L

K

L

L

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A

A

E

A

A

A

C

C

G

G

A

I

V

P

G

A

F

A

R

R

A

V

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T

K

K

P
x
K

S

A

D

D

V

L

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R

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E

I

A

I

I

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A

M

L

L

R

D

I

T

D

P

D

G

R

-

P

P

V

Y

I

L

M

L

D

D

F

V

H

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C

D

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R

H

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Q

E

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N

H

V

V

L

L

P

P

M

M

V

I

P

P

A
x
S

G

G

K

G

S

T

Y

F

R

N

D

D

M

V

I

I

L

T

D

E

-

G

D

D

G

G

K

R

binding 2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-2-[(1~{S})-1-(dioxidanyl)-1-oxidanyl-ethyl]-4-methyl-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate: V400 (= V397), G401 (= G398), Q402 (= Q399), H403 (= H400), G426 (= G423), M428 (= M425), G452 (= G449), D453 (= D450), G454 (= G451), S455 (= S452), M458 (= M455), N480 (= N477), H482 (≠ Y479), L483 (= L480), G484 (= G481), M485 (= M482), V486 (= V483)
binding flavin-adenine dinucleotide: R161 (= R152), G222 (= G215), G223 (= G216), G224 (= G217), T246 (= T241), L247 (≠ N242), M248 (= M243), L264 (= L259), M266 (= M261), H267 (= H262), G286 (= G281), V287 (≠ A282), R288 (= R283), D290 (= D285), R292 (= R287), V293 (= V288), D310 (= D305), I311 (= I306), D329 (= D324), V330 (= V325), M405 (= M402), G423 (= G420)
binding magnesium ion: F370 (≠ Y367), D453 (= D450), M458 (= M455), Q461 (= Q458), N480 (= N477), H482 (≠ Y479), K533 (≠ P523)
binding N-{[(4,6-dimethoxypyrimidin-2-yl)carbamoyl]sulfamoyl}-N-methylmethanesulfonamide: M266 (= M261), R292 (= R287), M485 (= M482), W489 (= W486), S568 (≠ A559)

5wj1A Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a triazolopyrimidine herbicide, penoxsulam (see paper)
50% identity, 98% coverage: 3:572/584 of query aligns to 12:582/582 of 5wj1A

query
sites
5wj1A

R

R

K

K

G

G

A

A

D

D

I

I

V

L

I

V

E

E

V

A

L

L

K

E

E

R

E

Q

G

G

V

V

E

E

V

T

I

V

F

F

G

A

H
x
Y

P

P

G
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G

A
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A

I
x
S

M

M

E

E

V

I

Y

H

D

Q

A

A

L

L

Y

T

R

R

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S

G

S

I

I

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R

H

N

I

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L

L

A

P

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R

H

H

E
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E

Q

Q

G

G

A

G

G

V

H

F

M

A

A

A

E

E

G

G

Y

Y

A

A

K

R

A

S

T

S

G

G

K

K

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P

G

G

V

I

A

C

M

I

A

A

T
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T

S

S

G

G

P

P

G

G

A

A

T

T

N

N

L

L

V

V

T

S

A

G

I

L

A

A

D

D

A

A

Y

L

M

L

D

D

S

S

V

V

P

P

V

L

V

V

F

A

I

I

T

T

G

G

Q

Q

V

V

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P

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H

R

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M

I

I

G

G

N

T

D

D

A

A

F
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F

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E
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E

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T

D

P

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I

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V

G

E

I

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T

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T

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H

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N

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E

D

D

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P

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I

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A

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F

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A

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G

G

R
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R

P

P

G

G

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L

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D

D

I

V

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K

D

D

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Q

Q

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Q

L

L

S

A

D

-

V

-

G

-

I

I

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N

L

W

E

E

E

Q

V

A

K

M

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-

L

L

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Y

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M

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M

E

P

G

K

N

P

P

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E

-

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-

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Q

H

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K

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L

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E

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A

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K

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K

P

P

V

V

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L

Y

Y

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G

A

C

V

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N

S

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E

-

A

-

Q

S

K

D

E

E

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A

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M

L

M

T

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G

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I

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P

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T

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x
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M

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M

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L

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M

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Y

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D

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R

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G

G

K

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E

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D

I
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I

D

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A

A

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I

S

G

K

K

N

N

I

K

V

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V

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C

G

G

D
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D

V
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V

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K

V

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A

L

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R

Q

-

G

-

M

-

N

K

K

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N

L

-

R

R

K

A

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F

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-

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G

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V
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V

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G

Q
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Q

H
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H

Q

Q

M
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M

W

W

A

A

M

Q

F

F

Y

Y

R

N

Y

Y

S

K

Y

K

P

P

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R

Q

Q

F

W

I

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N

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S

S

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G

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M

G

G

F

F

G

G

F

L

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P

A

A

G

A

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I

G

G

A

A

K

S

I

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G

A

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N

P

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D

D

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I

I

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G

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G

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S

F

F

M

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M
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M

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N

M

V

Q

Q

E

E

L

L

V

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T

T

A

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E

K

N

V

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P

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V

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K

V

V

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L

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L

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N

N
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x
H