SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing WP_013012039.1 NCBI__GCF_000025725.1:WP_013012039.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

O23346 Imidazoleglycerol-phosphate dehydratase 2, chloroplastic; IGPD 2; Protein HISTIDINE BIOSYNTHESIS 5B; EC 4.2.1.19 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
48% identity, 99% coverage: 3:194/194 of query aligns to 76:270/272 of O23346

query
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O23346

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E86 (= E13) binding substrate
H112 (= H39) binding Mn(2+)
112:120 (vs. 39:47, 44% identical) binding substrate
H138 (= H65) binding Mn(2+)
HHTNE 138:142 (≠ HHTAE 65:69) binding substrate
H139 (= H66) binding Mn(2+)
E142 (= E69) binding Mn(2+)
R164 (= R91) binding substrate
R186 (= R113) binding substrate
H210 (≠ E137) binding Mn(2+)
H234 (= H161) binding Mn(2+)
234:242 (vs. 161:169, 78% identical) binding substrate
H235 (= H162) binding Mn(2+)
E238 (= E165) binding Mn(2+)
SSK 264:266 (≠ STK 188:190) binding substrate

Sites not aligning to the query:

73 E→Q: Loss of activity.

5el9A A. Thaliana igpd2 in complex with the triazole-phosphonate inhibitor, (s)-c348, to 1.1a resolution (see paper)
48% identity, 99% coverage: 3:194/194 of query aligns to 3:197/199 of 5el9A

query
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5el9A

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binding [(2S)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]phosphonic acid: R91 (= R91), R113 (= R113), S191 (= S188), K193 (= K190)

5ekwA A. Thaliana igpd2 in complex with the racemate of the triazole- phosphonate inhibitor, c348 (see paper)
48% identity, 97% coverage: 3:191/194 of query aligns to 3:194/194 of 5ekwA

query
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binding [(2S)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]phosphonic acid: R91 (= R91), R113 (= R113), S191 (= S188), K193 (= K190)
binding [(2R)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]phosphonic acid: R91 (= R91), R113 (= R113), S191 (= S188), K193 (= K190)

P34047 Imidazoleglycerol-phosphate dehydratase 1, chloroplastic; IGPD 1; Protein HISTIDINE BIOSYNTHESIS 5A; EC 4.2.1.19 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
46% identity, 99% coverage: 3:194/194 of query aligns to 74:268/270 of P34047

query
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P34047

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H110 (= H39) binding Mn(2+)
H136 (= H65) binding Mn(2+)
H137 (= H66) binding Mn(2+)
E140 (= E69) binding Mn(2+)
H208 (≠ E137) binding Mn(2+)
H232 (= H161) binding Mn(2+)
H233 (= H162) binding Mn(2+)
E236 (= E165) binding Mn(2+)

4qnkA The structure of wt a. Thaliana igpd2 in complex with mn2+ and phosphate (see paper)
48% identity, 94% coverage: 3:184/194 of query aligns to 3:182/185 of 4qnkA

query
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4qnkA

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binding manganese (ii) ion: H39 (= H39), H65 (= H65), E69 (= E69), H137 (≠ E137), H161 (= H161), E165 (= E165)
binding phosphate ion: Q43 (≠ L43), H47 (= H47), K169 (= K169)

4mu1A The structure of wt a. Thaliana igpd2 in complex with mn2+, imidazole, and sulfate at 1.5 a resolution (see paper)
48% identity, 94% coverage: 3:184/194 of query aligns to 3:182/185 of 4mu1A

query
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4mu1A

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binding imidazole: H65 (= H65), E69 (= E69)
binding manganese (ii) ion: H65 (= H65), E69 (= E69), H137 (≠ E137)

4mu0A The structure of wt a. Thaliana igpd2 in complex with mn2+ and 1,2,4- triazole at 1.3 a resolution (see paper)
48% identity, 94% coverage: 3:184/194 of query aligns to 3:182/185 of 4mu0A

query
sites
4mu0A

R

R

K

I

A

G

T

E

I

V

E

K

R

R

K

E

T

T

T

K

E

E

T

T

D

N

V

V

S

S

I

V

T

K

L

I

N

N

V

L

D

D

G

G

K

H

G

G

K

V

Y

S

S

D

V

S

E

S

T

T

G

G

V

I

G

P

F

F

L

L

N

D

H

H

M

M

L

L

E

D

L

Q

F

L

S

A

R

S

H

H

G

G

S

L

F

F

D

D

L

V

T

H

V

V

N

R

A

A

N

T

G

G

D

D

T

T

H

H

I

I

D

D

A

D

H
|
H

T

T

A

N

E
|
E

D

D

I

V

G

A

I

L

V

A

L

I

G

G

E

T

A

A

F

L

V

L

K

K

A

A

L

L

G

G

D

E

K

R

R

K

G

G

I

I

A

N

R

R

Y

F

G

G

F

D

F

F

L

T

L

A

P

P

M

L

D

D

E

E

T

A

L

L

I

I

E

H

C

V

A

S

V

L

D

D

F

L

S

S

G

G

R

R

T

P

Y

Y

L

L

N

G

F

Y

D

N

A

L

P

E

I

I

P

P

A

T

E

Q

K

R

V

V

G

G

D

T

F

Y

D

D

T

T

E

Q

L

L

V

V

E

E

E
x
H

F

F

K

Q

A

S

F

L

A

V

D

N

R

T

A

S

G

G

I

M

N

T

L

L

H

H

I

I

I

R

K

Q

R

L

Y

A

G

G

R

K

N

N

T

S

H

H

I

I

E

E

G

A

I

T

F

F

K

K

C

A

V

F

A

A

R

R

A

A

I

L

K

R

T

Q

A

A

V

T

K

-

I

-

E

E

S

S

D

D

binding manganese (ii) ion: H65 (= H65), E69 (= E69), H137 (≠ E137)
binding 1,2,4-triazole: H65 (= H65), H66 (= H66)

4mu3A The form a structure of an e21q catalytic mutant of a. Thaliana igpd2 in complex with mn2+ and a mixture of its substrate, 2r3s-igp, and an inhibitor, 2s3s-igp, to 1.12 a resolution (see paper)
48% identity, 94% coverage: 3:184/194 of query aligns to 3:182/186 of 4mu3A

query
sites
4mu3A

R

R

K

I

A

G

T

E

I

V

E

K

R

R

K

E

T

T

T

K

E
x
Q

T

T

D

N

V

V

S

S

I

V

T

K

L

I

N

N

V

L

D

D

G

G

K

H

G

G

K

V

Y

S

S

D

V

S

E

S

T

T

G

G

V

I

G

P

F

F

L

L

N

D

H

H

M

M

L

L

E

D

L

Q

F

L

S

A

R

S

H

H

G

G

S

L

F

F

D

D

L

V

T

H

V

V

N

R

A

A

N

T

G

G

D

D

T

T

H

H

I

I

D

D

A

D

H
|
H

T

T

A

N

E
|
E

D

D

I

V

G

A

I

L

V

A

L

I

G

G

E

T

A

A

F

L

V

L

K

K

A

A

L

L

G

G

D

E

K

R

R

K

G

G

I

I

A

N

R

R

Y

F

G

G

F

D

F

F

L

T

L

A

P

P

M

L

D

D

E

E

T

A

L

L

I

I

E

H

C

V

A

S

V

L

D

D

F

L

S

S

G

G

R

R

T

P

Y

Y

L

L

N

G

F

Y

D

N

A

L

P

E

I

I

P

P

A

T

E

Q

K

R

V

V

G

G

D

T

F

Y

D

D

T

T

E

Q

L

L

V

V

E

E

E
x
H

F

F

K

Q

A

S

F

L

A

V

D

N

R

T

A

S

G

G

I

M

N

T

L

L

H

H

I

I

I

R

K

Q

R

L

Y

A

G

G

R

K

N

N

T

S

H

H

I

I

E

E

G

A

I

T

F

F

K

K

C

A

V

F

A

A

R

R

A

A

I

L

K

R

T

Q

A

A

V

T

K

-

I

-

E

E

S

S

D

D

binding (2S,3S)-2,3-dihydroxy-3-(1H-imidazol-5-yl)propyl dihydrogen phosphate: H65 (= H65), H66 (= H66)
binding (2R,3S)-2,3-dihydroxy-3-(1H-imidazol-5-yl)propyl dihydrogen phosphate: Q13 (≠ E13), H65 (= H65), H66 (= H66)
binding manganese (ii) ion: H65 (= H65), E69 (= E69), H137 (≠ E137)

Q9S5G5 Histidine biosynthesis bifunctional protein HisB; EC 3.1.3.15; EC 4.2.1.19 from Escherichia coli O157:H7 (see paper)
45% identity, 99% coverage: 2:193/194 of query aligns to 166:355/355 of Q9S5G5

query
sites
Q9S5G5

E
x
D

R

R

K

Y

A

A

T

H

I

V

E

V

R

R

K

N

T

T

T

K

E

E

T

T

D

Q

V

I

S

D

I

V

T

Q

L

V

N

W

V

L

D

D

G

R

K

E

G

G

K

G

Y

S

S

K

V

I

E

N

T

T

G

G

V

V

G

G

F

F

L

F

N

D

H

H

M

M

L

L

E

D

L

Q

F

I

S

A

R

T

H

H

G

G

S

G

F

F

D

R

L

M

T

E

V

I

N

N

A

V

N

K

G

G

D

D

T

L

H

Y

I

I

D

D

A

D

H

H

T

T

A

V

E

E

D

D

I

T

G

G

I

L

V

A

L

L

G

G

E

E

A

A

F

L

V

K

K

I

A

A

L

L

G

G

D

D

K

K

R

R

G

G

I

I

A

C

R

R

Y

F

G

G

F

-

F

F

L

V

L

L

P

P

M

M

D

D

E

E

T

C

L

L

I

A

E

R

C

C

A

A

V

L

D

D

F

I

S

S

G

G

R

R

T

P

Y

H

L

L

N

E

F

Y

D

K

A

A

P

E

I

F

P

T

A

Y

E

Q

K

R

V

V

G

G

D

D

F

L

D

S

T

T

E

E

L

M

V

I

E

E

E

H

F

F

K

R

A

S

F

L

A

S

D

Y

R

T

A

M

G

G

I

V

N

T

L

L

H

H

I

-

I

L

K

K

R

T

Y

K

G

G

R

K

N

N

T

D

H

H

I

R

I

V

E

E

G

S

I

L

F

F

K

K

C

A

V

F

A

G

R

R

A

T

I

L

K

R

T

Q

A

A

V

I

K

R

I

V

E

E

S

G

D

D

Q

T

I

L

P

P

S

S

T

S

K

K

G

G

S

V

L

L

Sites not aligning to the query:

1:166 Histidinol-phosphatase
9 binding Mg(2+)
11 binding Mg(2+)
17 E→A: Severe decrease in histidinol-phosphate phosphatase activity in presence of low magnesium concentration. At higher magnesium concentration (5mM), no effect on activity.
93 binding Zn(2+)
95 binding Zn(2+)
101 binding Zn(2+)
103 binding Zn(2+)
130 binding Mg(2+)

2f1dA X-ray structure of imidazoleglycerol-phosphate dehydratase (see paper)
47% identity, 93% coverage: 3:182/194 of query aligns to 2:181/183 of 2f1dA

query
sites
2f1dA

R

R

K

I

A

G

T

E

I

V

E

K

R

R

K

V

T

T

T

K

E

E

T

T

D

N

V

V

S

S

I

V

T

K

L

I

N

N

V

L

D

D

G

G

K

T

G

G

K

V

Y

A

S

D

V

S

E

S

T

S

G

G

V

I

G

P

F

F

L

L

N

D

H
|
H

M

M

L

L

E

D

L

Q

F

L

S

A

R

S

H

H

G

G

S

L

F

F

D

D

L

V

T

H

V

V

N

R

A

A

N

T

G

G

D

D

T

V

H

H

I

I

D

D

A

D

H
|
H

H

H

T

T

A

N

E
|
E

D

D

I

I

G

A

I

L

V

A

L

I

G

G

E

T

A

A

F

L

V

L

K

K

A

A

L

L

G

G

D

E

K

R

R

K

G

G

I

I

A

N

R

R

Y

F

G

G

F

D

F

F

L

T

L

A

P

P

M

L

D

D

E

E

T

A

L

L

I

I

E

H

C

V

A

S

V

L

D

D

F

L

S

S

G

G

R

R

T

P

Y

Y

L

L

N

G

F

Y

D

N

A

L

P

E

I

I

P

P

A

T

E

Q

K

R

V

V

G

G

D

T

F

Y

D

D

T

T

E

Q

L

L

V

V

E

E

E
x
H

F

F

K

Q

A

S

F

L

A

V

D

N

R

T

A

S

G

G

I

M

N

T

L

L

H

H

I

I

I

R

K

Q

R

L

Y

A

G

G

R

E

N

N

T

S

H
|
H

H

H

I

I

E
|
E

G

A

I

T

F

F

K

K

C

A

V

F

A

A

R

R

A

A

I

L

K

R

T

Q

A

A

V

T

K

E

I

T

E

D

binding manganese (ii) ion: H38 (= H39), H64 (= H65), E68 (= E69), H136 (≠ E137), H160 (= H161), E164 (= E165)

8qavA Medicago truncatula hisn5 (igpd) in complex with mn and ig2 (see paper)
46% identity, 93% coverage: 3:183/194 of query aligns to 2:182/184 of 8qavA

query
sites
8qavA

R

R

K

I

A

G

T

E

I

M

E

K

R

R

K

V

T

T

T

K

E

E

T

T

D

N

V

V

S

S

I

V

T

K

L

I

N

N

V

L

D

D

G

G

K

T

G

G

K

V

Y

A

S

D

V

N

E

S

T

S

G

G

V

I

G

P

F

F

L

L

N

D

H
|
H

M

M

L

L

E

D

L

Q

F

L

S

A

R

S

H

H

G

G

S

L

F

F

D

D

L

V

T

H

V

V

N

K

A

A

N

T

G

G

D

D

T

T

H

H

I

I

D

D

A

D

H
|
H

T

T

A

N

E
|
E

D

D

I

V

G

A

I

L

V

A

L

I

G

G

E

T

A

A

F

L

V

L

K

Q

A

A

L

L

G

G

D

D

K

R

R

K

G

G

I

I

A

N

R

R

Y

F

G

G

F

N

F

F

L

S

L

A

P

P

M

L

D

D

E

E

T

A

L

L

I

V

E

H

C

V

A

S

V

L

D

D

F

L

S

S

G

G

R

R

T

P

Y

H

L

L

N

G

F

Y

D

D

A

L

P

N

I

I

P

P

A

T

E

Q

K

R

V

V

G

G

D

K

F

Y

D

D

T

T

E

Q

L

L

V

V

E

E

E
x
H

F

F

K

Q

A

S

F

L

A

V

D

N

R

T

A

S

G

G

I

M

N

T

L

L

H

H

I

I

I

R

K

Q

R

F

Y

S

G

G

R

T

N

N

T

S

H
|
H

H

H

I

I

E
|
E

G

A

I

T

F

F

K

K

C

A

V

F

A

A

R

R

A

A

I

L

K

R

T

Q

A

A

V

T

K

E

I

Y

E

D

S

T

binding (2S,3S)-2,3-dihydroxy-3-(1H-imidazol-5-yl)propyl dihydrogen phosphate: H64 (= H65), H65 (= H66)
binding manganese (ii) ion: H38 (= H39), H64 (= H65), E68 (= E69), H136 (≠ E137), H160 (= H161), E164 (= E165)

8qawA Medicago truncatula hisn5 (igpd) in complex with mn, imd, edo, fmt, gol and trs (see paper)
46% identity, 93% coverage: 3:183/194 of query aligns to 3:183/185 of 8qawA

query
sites
8qawA

R

R

K

I

A

G

T

E

I

M

E

K

R

R

K

V

T

T

T

K

E
|
E

T

T

D

N

V

V

S

S

I

V

T

K

L

I

N

N

V

L

D

D

G

G

K

T

G

G

K

V

Y

A

S

D

V

N

E

S

T

S

G

G

V

I

G

P

F

F

L

L

N

D

H
|
H

M

M

L

L

E

D

L
x
Q

F

L

S

A

R

S

H
|
H

G

G

S

L

F

F

D

D

L

V

T

H

V

V

N

K

A

A

N

T

G

G

D

D

T

T

H

H

I

I

D

D

A

D

H
|
H

T

T

A

N

E
|
E

D

D

I

V

G

A

I

L

V

A

L

I

G

G

E

T

A

A

F

L

V

L

K

Q

A

A

L

L

G

G

D

D

K

R

R

K

G

G

I

I

A

N

R

R

Y

F

G

G

F

N

F

F

L

S

L

A

P

P

M

L

D

D

E

E

T

A

L

L

I

V

E

H

C

V

A

S

V

L

D

D

F

L

S

S

G

G

R

R

T

P

Y

H

L

L

N

G

F

Y

D

D

A

L

P

N

I

I

P

P

A

T

E

Q

K

R

V

V

G

G

D

K

F

Y

D

D

T

T

E

Q

L

L

V

V

E

E

E
x
H

F

F

K

Q

A

S

F

L

A

V

D

N

R

T

A

S

G

G

I

M

N

T

L

L

H

H

I

I

I

R

K

Q

R

F

Y

S

G

G

R

T

N

N

T

S

H
|
H

H

H

I

I

E
|
E

G

A

I

T

F

F

K
|
K

C

A

V

F

A

A

R

R

A

A

I

L

K

R

T

Q

A

A

V

T

K

E

I

Y

E

D

S

T

binding glycerol: Q43 (≠ L43), H47 (= H47), K169 (= K169)
binding imidazole: E13 (= E13), H66 (= H66), E69 (= E69)
binding manganese (ii) ion: H39 (= H39), H65 (= H65), E69 (= E69), H137 (≠ E137), H161 (= H161), E165 (= E165)

6fwhL Acanthamoeba igpd in complex with r-c348 to 1.7a resolution (see paper)
43% identity, 99% coverage: 2:193/194 of query aligns to 1:194/195 of 6fwhL

query
sites
6fwhL

E

K

R

R

K

E

A

A

T
x
Q

I

V

E

A

R

R

K

E

T

T

T

G

E
|
E

T

T

D

K

V

I

S

E

I

V

T

R

L

L

N

S

V

L

D

D

G

G

K

T

G

G

K

V

Y

S

S

D

V

V

E

K

T

T

G

G

V

I

G

G

F

F

L

L

N

D

H
|
H

M

M

L

L

E

S

L

A

F

L

S

A

R

K

H

H

G

G

S

R

F

F

D

D

L

L

T

Y

V

L

N

R

A

C

N

A

G

G

D

D

T

L

H

H

I

V

D

D

A

D

H
|
H

T

T

A

S

E
|
E

D

D

I

C

G

A

I

I

V

V

L

L

G

G

E

Q

A

A

F

F

V

R

K
x
Q

A

A

L

I

G

G

D

E

K

R

R

K

G

G

I

I

A

K

R
|
R

Y

Y

G

G

F

S

F

A

L

Y

L

A

P

P

M

L

D

D

E

E

T

S

L

L

I

A

E

R

C

A

A

V

V

V

D

D

F

I

S

S

G

S

R
|
R

T

P

Y

F

L

A

N

V

F

I

D

D

A

L

P

K

I

L

P

K

A

R

E

E

K

K

V

I

G

G

D

E

F

L

D

S

T

C

E

E

L

M

V

I

E

P

E
x
H

F

V

F

L

K

H

A

S

F

F

A

A

D

T

R

S

A

A

G

N

I

L

N

T

L

L

H

H

I

V

I

E

K

V

R

L

Y

Y

G

G

R

A

N

N

T

D

H
|
H

I

K

I

A

E
|
E

G

S

I

A

F

F

K

K

C

A

V

T

A

A

R

L

A

A

I

L

K

R

T

E

A

A

V

V

K

T

I

K

E

D

-

G

-

P

S

A

D

D

Q

A

I

V

P

P

S
|
S

T

T

K
|
K

G

G

S

V

L

L

binding [(2R)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]phosphonic acid: E12 (= E13), H38 (= H39), H64 (= H65), H65 (= H66), E68 (= E69), R90 (= R91), R112 (= R113), H160 (= H161), H161 (= H162), E164 (= E165), S189 (= S188), K191 (= K190)
binding magnesium ion: Q5 (≠ T6), Q80 (≠ K81)
binding manganese (ii) ion: H38 (= H39), H64 (= H65), E68 (= E69), H136 (≠ E137), H160 (= H161), E164 (= E165)

6fwhA Acanthamoeba igpd in complex with r-c348 to 1.7a resolution (see paper)
43% identity, 99% coverage: 2:193/194 of query aligns to 2:195/196 of 6fwhA

query
sites
6fwhA

E

K

R

R

K

E

A

A

T

Q

I

V

E

A

R

R

K

E

T

T

T

G

E
|
E

T

T

D

K

V

I

S

E

I

V

T

R

L

L

N

S

V

L

D

D

G

G

K

T

G

G

K

V

Y

S

S

D

V

V

E

K

T

T

G

G

V

I

G

G

F

F

L

L

N

D

H
|
H

M

M

L

L

E

S

L

A

F

L

S

A

R

K

H

H

G

G

S

R

F

F

D

D

L

L

T

Y

V

L

N

R

A

C

N

A

G

G

D

D

T

L

H

H

I

V

D

D

A

D

H
|
H

T

T

A

S

E
|
E

D

D

I

C

G

A

I

I

V

V

L

L

G

G

E

Q

A

A

F

F

V

R

K

Q

A

A

L

I

G

G

D

E

K

R

R

K

G

G

I

I

A

K

R
|
R

Y

Y

G

G

F

S

F

A

L

Y

L

A

P

P

M

L

D

D

E

E

T

S

L

L

I

A

E

R

C

A

A

V

V

V

D

D

F

I

S

S

G

S

R
|
R

T

P

Y

F

L

A

N

V

F

I

D

D

A

L

P

K

I

L

P

K

A

R

E

E

K

K

V

I

G

G

D

E

F

L

D

S

T

C

E

E

L

M

V

I

E

P

E
x
H

F

V

F

L

K

H

A

S

F

F

A

A

D

T

R

S

A

A

G

N

I

L

N

T

L

L

H

H

I

V

I

E

K

V

R

L

Y

Y

G

G

R

A

N

N

T

D

H
|
H

I

K

I

A

E
|
E

G

S

I

A

F

F

K

K

C

A

V

T

A

A

R

L

A

A

I

L

K

R

T

E

A

A

V

V

K

T

I

K

E

D

-

G

-

P

S

A

D

D

Q

A

I

V

P

P

S
|
S

T

T

K
|
K

G

G

S

V

L

L

binding [(2R)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]phosphonic acid: E13 (= E13), H39 (= H39), H65 (= H65), H66 (= H66), E69 (= E69), R91 (= R91), R113 (= R113), H161 (= H161), H162 (= H162), E165 (= E165), S190 (= S188), K192 (= K190)
binding manganese (ii) ion: H39 (= H39), H65 (= H65), E69 (= E69), H137 (≠ E137), H161 (= H161), E165 (= E165)

P9WML9 Imidazoleglycerol-phosphate dehydratase; IGPD; EC 4.2.1.19 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
46% identity, 93% coverage: 13:193/194 of query aligns to 21:210/210 of P9WML9

query
sites
P9WML9

E

E

T

S

D

D

V

I

S

V

I

I

T

E

L

L

N

D

V

L

D

D

G

G

K

T

G

G

K

Q

Y

V

S

A

V

V

E

D

T

T

G

G

V

V

G

P

F

F

L

Y

N

D

H
|
H

M
|
M

L
|
L

E
x
T

L
x
A

F
x
L

S
x
G

R
x
S

H
|
H

G

A

S

S

F

F

D

D

L

L

T

T

V

V

N

R

A

A

N

T

G

G

D

D

T

V

H

E

I

I

D

E

A

A

H
|
H

T
|
T

A
x
I

E
|
E

D

D

I

T

G

A

I

I

V

A

L

L

G

G

E

T

A

A

F

L

V

G

K

Q

A

A

L

L

G

G

D

D

K

K

R

R

G

G

I

I

A

R

R

R

Y

F

G

G

F

D

F

A

L

F

L

I

P

P

M

M

D

D

E

E

T

T

L

L

I

A

E

H

C

A

A

A

V

V

D

D

F

L

S

S

G

G

R

R

T

P

Y

Y

L

C

-

V

-

H

-

T

-

G

-

E

-

P

-

D

N

H

F

L

D

Q

A

H

P

T

I

T

P

I

A

A

E

G

K

S

V

S

G

V

D

P

F

Y

D

H

T

T

E

V

L

I

V

N

E

R

E
x
H

F

V

F

F

K

E

A

S

F

L

A

A

D

A

R

N

A

A

G

R

I

I

N

A

L

L

H

H

I

V

I

R

K

V

R

L

Y

Y

G

G

R

R

N

D

T

P

H
|
H

I
|
I

I
x
T

E
|
E

G
x
A

I
x
Q

F
x
Y

K
|
K

C

A

V

V

A

A

R

R

A

A

I

L

K

R

T

Q

A

A

V

V

K

E

I

P

E

D

S

P

-

R

-

V

D

S

Q

G

I

V

P

P

S

S

T

T

K

K

G

G

S

A

L

L

H47 (= H39) binding Mn(2+)
47:55 (vs. 39:47, 44% identical) binding substrate
H73 (= H65) binding Mn(2+)
HHTIE 73:77 (≠ HHTAE 65:69) binding substrate
H74 (= H66) binding Mn(2+)
E77 (= E69) binding Mn(2+)
H152 (≠ E137) binding Mn(2+)
H176 (= H161) binding Mn(2+)
176:184 (vs. 161:169, 56% identical) binding substrate
H177 (= H162) binding Mn(2+)
E180 (= E165) binding Mn(2+)

2ae8B Crystal structure of imidazoleglycerol-phosphate dehydratase from staphylococcus aureus subsp. Aureus n315
47% identity, 89% coverage: 8:179/194 of query aligns to 5:169/172 of 2ae8B

query
sites
2ae8B

E

Q

R

K

K

Q

T

R

T

N

E

Q

T

L

D

N

V

I

S

S

I

I

T

S

L

-

N

-

V

-

D

D

G

D

K

Q

G

S

K

P

Y

S

S

H

V

I

E

N

T

T

G

G

V

V

G

G

F

F

L

L

N

N

H
|
H

M

M

L

L

E

T

L

L

F

F

S

T

R

F

H

H

G

S

S

G

F

L

D

S

L

L

T

N

V

I

N

E

A

A

N

Q

G

G

D

D

T

D

H
|
H

I

-

D

-

A

-

H

-

H

H

T

V

A

T

E
|
E

D

D

I

I

G

G

I

I

V

V

L

I

G

G

E

Q

A

L

F

L

V

L

K

E

A

M

L

I

G

K

D

D

K

K

R

K

G

H

I

F

A

V

R

R

Y

Y

G

G

F

T

F

M

L

Y

L

I

P

P

M

M

D

D

E

E

T

T

L

L

I

A

E

R

C

V

A

V

V

V

D

D

F

I

S

S

G

G

R

R

T

P

Y

Y

L

L

N

S

F

F

D

N

A

A

P

S

I

L

P

S

A

K

E

E

K

K

V

V

G

G

D

T

F

F

D

D

T

T

E

E

L

L

V

V

E

E

F

F

K

R

A

A

F

V

A

V

D

I

R

N

A

A

G

R

I

L

N

T

L

T

H

H

I

I

I

D

K

L

R

I

Y

R

G

G

R

G

N

N

T

T

H
|
H

H

H

I

E

I

I

E
|
E

G

A

I

I

F

F

K

K

C

A

V

F

A

S

R

R

A

A

I

L

K

G

T

I

A

A

V

L

binding magnesium ion: H33 (= H39), H55 (= H61), E59 (= E69), H151 (= H161), E155 (= E165)

1rhyB Crystal structure of imidazole glycerol phosphate dehydratase (see paper)
43% identity, 92% coverage: 2:179/194 of query aligns to 2:177/180 of 1rhyB

query
sites
1rhyB

E

E

R

R

K

I

A

A

T

S

I

V

E

E

R

R

K

T

T

T

T

S

E

E

T

T

D

H

V

I

S

S

I

C

T

T

L

I

N

D

V

L

D

D

-

H

-

I

-

P

-

G

-

V

G

T

K

E

G

Q

K

K

Y

I

S

N

V

V

E

S

T

T

G

G

V

I

G

G

F

F

L

L

N

D

H

H

M

M

L

F

E

T

L

A

F

L

S

A

R

K

H

H

G

G

S

G

F

M

D

S

L

L

T

Q

V

L

N

Q

A

C

N

K

G

G

D

D

T

T

H

-

I

-

D

-

A

-

H

-

T

-

A

A

E

E

D

D

I

C

G

A

I

L

V

A

L

L

G

G

E

E

A

A

F

F

V

K

K

K

A

A

L

L

G

G

D

E

K

R

R

K

G

G

I

I

A

K

R

R

Y

Y

G

G

F

Y

F

A

L

Y

L

A

P

P

M

L

D

D

E

E

T

S

L

L

I

S

E

R

C

A

A

V

V

I

D

D

F

I

S

S

G

S

R

R

T

P

Y

Y

L

F

N

M

F

C

D

H

A

L

P

P

I

F

P

T

A

R

E

E

K

K

V

V

G
|
G

D

D

F

L

D

S

T

T

E

E

L

M

V

V

E

S

E

H

F

L

K

Q

A

S

F

F

A

A

D

F

R

A

A

A

G

G

I

V

N

T

L

L

H

H

I

I

I

D

K

S

R

I

Y

R

G

G

R

E

N

N

T

N

H
|
H

H

H

I

I

I

A

E

E

G

S

I

A

F

F

K

K

C

A

V

L

A

A

R

L

A

A

I

I

K

R

T

M

A

A

V

I

binding glycerol: G126 (= G128), H159 (= H161)

5xdsA Crystal structure of mycobacterium tuberculosis hisb bound with an inhibitor (see paper)
46% identity, 87% coverage: 13:180/194 of query aligns to 12:186/191 of 5xdsA

query
sites
5xdsA

E

E

T

S

D

D

V

I

S

V

I

I

T

E

L

L

N

D

V

L

D

D

G

G

K

T

G

G

K

Q

Y

V

S

A

V

V

E

D

T

T

G

G

V

V

G

P

F

F

L

Y

N

D

H
|
H

M

M

L

L

E

T

L

A

F

L

S

G

R

S

H

H

G

A

S

S

F

F

D

D

L

L

T

T

V

V

N

R

A

A

N

T

G

G

D

D

T

V

H

E

I

I

D

E

A

A

H
|
H

T

T

A

I

E
|
E

D

D

I

T

G

A

I

I

V

A

L

L

G

G

E

T

A

A

F

L

V

G

K

Q

A

A

L

L

G

G

D

D

K

K

R

R

G

G

I

I

A

R

R

R

Y

F

G

G

F

D

F

A

L

F

L

I

P

P

M

M

D

D

E

E

T

T

L

L

I

A

E

H

C

A

A

A

V

V

D

D

F

L

S

S

G

G

R

R

T

P

Y

Y

L

C

-

V

-

H

-

T

-

G

-

E

-

P

-

D

N

H

F

L

D

Q

A

H

P

T

I

T

P

I

A

A

E

G

K

S

V

S

G

V

D

P

F

Y

D

H

T

T

E

V

L

I

V

N

E

R

E
x
H

F

V

F

F

K

E

A

S

F

L

A

A

D

A

R

N

A

A

G

R

I

I

N

A

L

L

H

H

I

V

I

R

K

V

R

L

Y

Y

G

G

R

R

N

D

T

P

H
|
H

H

H

I

I

I

T

E
|
E

G

A

I

Q

F

Y

K

K

C

A

V

V

A

A

R

R

A

A

I

L

K

R

T

Q

A

A

V

V

K

E

binding (2S)-2-azanyl-3-(4H-1,2,4-triazol-3-yl)propanoic acid: H64 (= H65), H65 (= H66), E68 (= E69)
binding manganese (ii) ion: H38 (= H39), H64 (= H65), E68 (= E69), H143 (≠ E137), H167 (= H161), E171 (= E165)

4lomA Crystal structure of mycobacterium tuberculosis hisb in complex with its substrate
46% identity, 87% coverage: 13:180/194 of query aligns to 12:186/191 of 4lomA

query
sites
4lomA

E

E

T

S

D

D

V

I

S

V

I

I

T

E

L

L

N

D

V

L

D

D

G

G

K

T

G

G

K

Q

Y

V

S

A

V

V

E

D

T

T

G

G

V

V

G

P

F

F

L

Y

N

D

H
|
H

M

M

L

L

E

T

L

A

F

L

S

G

R

S

H

H

G

A

S

S

F

F

D

D

L

L

T

T

V

V

N

R

A

A

N

T

G

G

D

D

T

V

H

E

I

I

D

E

A

A

H
|
H

H

H

T

T

A

I

E
|
E

D

D

I

T

G

A

I

I

V

A

L

L

G

G

E

T

A

A

F

L

V

G

K

Q

A

A

L

L

G

G

D

D

K

K

R

R

G

G

I

I

A

R

R

R

Y

F

G

G

F

D

F

A

L

F

L

I

P

P

M
|
M

D

D

E

E

T

T

L

L

I

A

E

H

C

A

A

A

V

V

D

D

F

L

S

S

G

G

R

R

T

P

Y

Y

L

C

-

V

-

H

-

T

-

G

-

E

-

P

-

D

N

H

F

L

D

Q

A

H

P

T

I

T

P

I

A

A

E

G

K

S

V

S

G

V

D

P

F

Y

D

H

T

T

E

V

L

I

V

N

E

R

E
x
H

F

V

F

F

K

E

A

S

F

L

A

A

D

A

R

N

A

A

G

R

I

I

N

A

L

L

H

H

I

V

I

R

K

V

R

L

Y

Y

G

G

R

R

N

D

T

P

H
|
H

I

I

I

T

E
|
E

G

A

I

Q

F

Y

K
|
K

C

A

V

V

A

A

R

R

A

A

I

L

K

R

T

Q

A

A

V

V

K

E

binding (2R,3S)-2,3-dihydroxy-3-(1H-imidazol-5-yl)propyl dihydrogen phosphate: H38 (= H39), M98 (= M99), H167 (= H161), H168 (= H162), E171 (= E165), K175 (= K169)
binding manganese (ii) ion: H38 (= H39), H64 (= H65), E68 (= E69), H143 (≠ E137), H167 (= H161), E171 (= E165)

4gquA Crystal structure of hisb from mycobacterium tuberculosis
46% identity, 87% coverage: 13:180/194 of query aligns to 12:186/191 of 4gquA

query
sites
4gquA

E

E

T

S

D

D

V

I

S

V

I

I

T

E

L

L

N

D

V

L

D

D

G

G

K

T

G

G

K

Q

Y

V

S

A

V

V

E

D

T

T

G

G

V

V

G

P

F

F

L

Y

N

D

H
|
H

M

M

L

L

E

T

L

A

F

L

S

G

R

S

H

H

G

A

S

S

F

F

D

D

L

L

T

T

V

V

N

R

A

A

N

T

G

G

D

D

T

V

H

E

I

I

D

E

A

A

H
|
H

H

H

T

T

A

I

E
|
E

D

D

I

T

G

A

I

I

V

A

L

L

G

G

E

T

A

A

F

L

V

G

K

Q

A

A

L

L

G

G

D

D

K

K

R

R

G

G

I

I

A

R

R

R

Y

F

G

G

F

D

F

A

L

F

L

I

P

P

M

M

D

D

E

E

T

T

L

L

I

A

E

H

C

A

A

A

V

V

D

D

F

L

S

S

G

G

R

R

T

P

Y

Y

L

C

-

V

-

H

-

T

-

G

-

E

-

P

-

D

N

H

F

L

D

Q

A

H

P

T

I

T

P

I

A

A

E

G

K

S

V

S

G

V

D

P

F

Y

D

H

T

T

E

V

L

I

V

N

E

R

E
x
H

F

V

F

F

K

E

A

S

F

L

A

A

D

A

R

N

A

A

G

R

I

I

N

A

L

L

H

H

I

V

I

R

K

V

R

L

Y

Y

G

G

R

R

N

D

T

P

H
|
H

H

H

I

I

I

T

E
|
E

G

A

I

Q

F

Y

K

K

C

A

V

V

A

A

R

R

A

A

I

L

K

R

T

Q

A

A

V

V

K

E

binding manganese (ii) ion: H38 (= H39), H64 (= H65), E68 (= E69), H143 (≠ E137), H167 (= H161), E171 (= E165)

Query Sequence

>WP_013012039.1 NCBI__GCF_000025725.1:WP_013012039.1
MERKATIERKTTETDVSITLNVDGKGKYSVETGVGFLNHMLELFSRHGSFDLTVNANGDT
HIDAHHTAEDIGIVLGEAFVKALGDKRGIARYGFFLLPMDETLIECAVDFSGRTYLNFDA
PIPAEKVGDFDTELVEEFFKAFADRAGINLHIIKRYGRNTHHIIEGIFKCVARAIKTAVK
IESDQIPSTKGSLA

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory