SitesBLAST
Comparing WP_013074321.1 NCBI__GCF_000092905.1:WP_013074321.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
6thqB Crystal structure of branched-chain aminotransferase from thermophilic archaea thermoproteus uzoniensis with norvaline
45% identity, 94% coverage: 20:317/318 of query aligns to 9:301/301 of 6thqB
- active site: F37 (= F48), K156 (= K169), E190 (= E203), L214 (= L227)
- binding pyridoxal-5'-phosphate: R60 (= R73), K156 (= K169), Y161 (= Y174), E190 (= E203), N195 (= N208), L214 (= L227), G216 (= G229), I217 (≠ V230), T218 (= T231), T254 (= T267)
- binding 2-[o-phosphonopyridoxyl]-amino-pentanoic acid: R60 (= R73), Y97 (= Y110), K156 (= K169), Y161 (= Y174), E190 (= E203), G193 (≠ S206), E194 (≠ A207), N195 (= N208), G216 (= G229), I217 (≠ V230), T218 (= T231), G253 (= G266), T254 (= T267), A255 (≠ G268)
2ej0B Crystal structure of t.Th.Hb8 branched-chain amino acid aminotransferase with pyridoxamine 5'-phosphate
39% identity, 95% coverage: 14:316/318 of query aligns to 1:304/305 of 2ej0B
- active site: F35 (= F48), G37 (= G50), K158 (= K169), E192 (= E203), L215 (= L227)
- binding 4'-deoxy-4'-aminopyridoxal-5'-phosphate: R58 (= R73), Y163 (= Y174), E192 (= E203), G195 (≠ S206), E196 (≠ A207), L215 (= L227), G217 (= G229), I218 (≠ V230), T219 (= T231), G254 (= G266), T255 (= T267)
2ej3A Crystal structure of t.Th.Hb8 branched-chain amino acid aminotransferase complexed with gabapentin
39% identity, 95% coverage: 14:316/318 of query aligns to 1:296/297 of 2ej3A
- active site: F35 (= F48), G37 (= G50), K150 (= K169), E184 (= E203), L207 (= L227)
- binding [1-(aminomethyl)cyclohexyl]acetic acid: G187 (≠ S206), G246 (= G266), T247 (= T267), A248 (≠ G268)
- binding pyridoxal-5'-phosphate: R58 (= R73), K150 (= K169), Y155 (= Y174), E184 (= E203), G187 (≠ S206), L207 (= L227), G209 (= G229), I210 (≠ V230), T211 (= T231), G246 (= G266), T247 (= T267)
2eiyA Crystal structure of t.Th.Hb8 branched-chain amino acid aminotransferase complexed with 4-methylvaleric acid
39% identity, 95% coverage: 14:316/318 of query aligns to 1:296/297 of 2eiyA
- active site: F35 (= F48), G37 (= G50), K150 (= K169), E184 (= E203), L207 (= L227)
- binding 4-methyl valeric acid: F35 (= F48), Y94 (= Y110), T247 (= T267), A248 (≠ G268)
- binding pyridoxal-5'-phosphate: R58 (= R73), K150 (= K169), Y155 (= Y174), E184 (= E203), G187 (≠ S206), E188 (≠ A207), L207 (= L227), G209 (= G229), I210 (≠ V230), T211 (= T231), G246 (= G266), T247 (= T267)
1wrvA Crystal structure of t.Th.Hb8 branched-chain amino acid aminotransferase
39% identity, 95% coverage: 14:316/318 of query aligns to 1:296/297 of 1wrvA
- active site: F35 (= F48), G37 (= G50), K150 (= K169), E184 (= E203), L207 (= L227)
- binding pyridoxal-5'-phosphate: R58 (= R73), K150 (= K169), Y155 (= Y174), E184 (= E203), G187 (≠ S206), L207 (= L227), G209 (= G229), I210 (≠ V230), T211 (= T231), T247 (= T267)
6h65C Crystal structure of the branched-chain-amino-acid aminotransferase from haliangium ochraceum
39% identity, 94% coverage: 19:317/318 of query aligns to 6:307/308 of 6h65C
- active site: F35 (= F48), K158 (= K169), E192 (= E203), L216 (= L227)
- binding pyridoxal-5'-phosphate: R60 (= R73), K158 (= K169), Y163 (= Y174), E192 (= E203), A196 (= A207), L216 (= L227), S218 (≠ G229), V219 (= V230), T220 (= T231), G256 (= G266), T257 (= T267)
6q8eA Crystal structure of branched-chain amino acid aminotransferase from thermobaculum terrenum in pmp-form (see paper)
39% identity, 94% coverage: 19:316/318 of query aligns to 5:304/307 of 6q8eA
- active site: F34 (= F48), K156 (= K169), E190 (= E203), L214 (= L227)
- binding 4'-deoxy-4'-aminopyridoxal-5'-phosphate: R59 (= R73), K156 (= K169), Y161 (= Y174), E190 (= E203), G193 (≠ S206), S194 (≠ A207), C195 (≠ N208), L214 (= L227), S216 (≠ G229), I217 (≠ V230), T218 (= T231), G254 (= G266), T255 (= T267)
2ej2A Crystal structure of t.Th.Hb8 branched-chain amino acid aminotransferase complexed with n-(5'-phosphopyridoxyl)-l-glutamate
39% identity, 95% coverage: 14:316/318 of query aligns to 1:293/294 of 2ej2A
- active site: F35 (= F48), G37 (= G50), K147 (= K169), E181 (= E203), L204 (= L227)
- binding 4-[(1,3-dicarboxy-propylamino)-methyl]-3-hydroxy-2-methyl-5-phosphonooxymethyl-pyridinium: R58 (= R73), Y94 (= Y110), Y152 (= Y174), E181 (= E203), G184 (≠ S206), E185 (≠ A207), L204 (= L227), G206 (= G229), I207 (≠ V230), T208 (= T231), T244 (= T267), A245 (≠ G268)
7neaA Crystal structure of branched-chain amino acid aminotransferase from thermobaculum terrenum (m3 mutant). (see paper)
38% identity, 94% coverage: 19:316/318 of query aligns to 5:304/309 of 7neaA
- active site: F34 (= F48), K156 (= K169), E190 (= E203), L214 (= L227)
- binding pyridoxal-5'-phosphate: R59 (= R73), K156 (= K169), Y161 (= Y174), E190 (= E203), G193 (≠ S206), S194 (≠ A207), L214 (= L227), S216 (≠ G229), I217 (≠ V230), T218 (= T231), T255 (= T267)
4whxA X-ray crystal structure of an amino acid aminotransferase from burkholderia pseudomallei bound to the co-factor pyridoxal phosphate
40% identity, 94% coverage: 18:316/318 of query aligns to 7:306/306 of 4whxA
1iyeA Crystal structure of eschelichia coli branched-chain amino acid aminotransferase (see paper)
39% identity, 94% coverage: 19:316/318 of query aligns to 4:303/304 of 1iyeA
- active site: F33 (= F48), G35 (= G50), K156 (= K169), A157 (≠ V170), E190 (= E203), L214 (= L227)
- binding N-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)-L-glutamic acid: R56 (= R73), Y92 (= Y110), Y126 (= Y143), K156 (= K169), Y161 (= Y174), E190 (= E203), G193 (≠ S206), E194 (≠ A207), N195 (= N208), L214 (= L227), G216 (= G229), I217 (≠ V230), T218 (= T231), G253 (= G266), T254 (= T267), A255 (≠ G268)
1iydA Crystal structure of eschelichia coli branched-chain amino acid aminotransferase (see paper)
39% identity, 94% coverage: 19:316/318 of query aligns to 4:303/304 of 1iydA
- active site: F33 (= F48), G35 (= G50), K156 (= K169), A157 (≠ V170), E190 (= E203), L214 (= L227)
- binding glutaric acid: Y92 (= Y110), Y126 (= Y143), A255 (≠ G268)
- binding pyridoxal-5'-phosphate: R56 (= R73), K156 (= K169), Y161 (= Y174), E190 (= E203), G193 (≠ S206), E194 (≠ A207), L214 (= L227), G216 (= G229), I217 (≠ V230), T218 (= T231), T254 (= T267)
1i1mA Crystal structure of escherichia coli branched-chain amino acid aminotransferase. (see paper)
39% identity, 94% coverage: 19:316/318 of query aligns to 4:303/304 of 1i1mA
- active site: K156 (= K169)
- binding 4-methyl valeric acid: Y92 (= Y110), K156 (= K169), T254 (= T267), A255 (≠ G268)
- binding pyridoxal-5'-phosphate: R56 (= R73), K156 (= K169), Y161 (= Y174), E190 (= E203), G193 (≠ S206), E194 (≠ A207), L214 (= L227), G216 (= G229), I217 (≠ V230), T218 (= T231), G253 (= G266), T254 (= T267)
1i1lA Crystal structure of eschelichia coli branched-chain amino acid aminotransferase. (see paper)
39% identity, 94% coverage: 19:316/318 of query aligns to 4:303/304 of 1i1lA
- active site: K156 (= K169)
- binding 2-methylleucine: Y92 (= Y110), K156 (= K169), T254 (= T267), A255 (≠ G268)
- binding pyridoxal-5'-phosphate: R56 (= R73), K156 (= K169), Y161 (= Y174), E190 (= E203), G193 (≠ S206), G216 (= G229), I217 (≠ V230), T218 (= T231), T254 (= T267)
5mr0D Thermophilic archaeal branched-chain amino acid transaminases from geoglobus acetivorans and archaeoglobus fulgidus: biochemical and structural characterisation (see paper)
39% identity, 87% coverage: 19:296/318 of query aligns to 3:275/290 of 5mr0D
- active site: F32 (= F48), G34 (= G50), K150 (= K169), E183 (= E203), L206 (= L227)
- binding 3-[o-phosphonopyridoxyl]--amino-benzoic acid: R51 (= R73), G100 (≠ K123), L101 (≠ V124), K150 (= K169), Y154 (= Y174), E183 (= E203), G186 (≠ S206), D187 (≠ A207), L206 (= L227), I209 (≠ V230), T210 (= T231), G245 (= G266), T246 (= T267)
5e25A Crystal structure of branched-chain aminotransferase from thermophilic archaea geoglobus acetivorans complexed with alpha-ketoglutarate (see paper)
37% identity, 88% coverage: 20:298/318 of query aligns to 5:278/290 of 5e25A
- active site: F33 (= F48), G35 (= G50), K151 (= K169), E184 (= E203), L207 (= L227)
- binding 2-oxoglutaric acid: Y88 (= Y110), K151 (= K169), T247 (= T267), A248 (≠ G268)
- binding pyridoxal-5'-phosphate: R52 (= R73), K151 (= K169), Y155 (= Y174), E184 (= E203), G187 (≠ S206), D188 (≠ A207), L207 (= L227), G209 (= G229), I210 (≠ V230), T211 (= T231), G246 (= G266), T247 (= T267)
6xu3C (R)-selective amine transaminase from shinella sp. (see paper)
28% identity, 93% coverage: 15:311/318 of query aligns to 25:310/322 of 6xu3C
- active site: Y58 (≠ F48), K178 (≠ A168), E211 (= E203), L233 (= L227)
- binding n-glycine-[3-hydroxy-2-methyl-5-phosphonooxymethyl-pyridin-4-yl-methane]: V60 (≠ I51), R77 (= R73), K178 (≠ A168), F185 (≠ I175), E211 (= E203), G214 (≠ S206), N216 (= N208), L233 (= L227), G235 (= G229), V236 (= V230), T237 (= T231), T272 (≠ G266), T273 (= T267), A274 (≠ G268)
6xu3B (R)-selective amine transaminase from shinella sp. (see paper)
28% identity, 93% coverage: 15:311/318 of query aligns to 24:309/321 of 6xu3B
- active site: Y57 (≠ F48), K177 (≠ A168), E210 (= E203), L232 (= L227)
- binding 3-aminobenzoic acid: P169 (vs. gap), D173 (≠ I164), K229 (≠ A224)
- binding n-glycine-[3-hydroxy-2-methyl-5-phosphonooxymethyl-pyridin-4-yl-methane]: R76 (= R73), Y112 (= Y110), K177 (≠ A168), F184 (≠ I175), E210 (= E203), G213 (≠ S206), F214 (≠ A207), N215 (= N208), L232 (= L227), G234 (= G229), V235 (= V230), T236 (= T231), T272 (= T267)
6xu3A (R)-selective amine transaminase from shinella sp. (see paper)
28% identity, 93% coverage: 15:311/318 of query aligns to 23:308/320 of 6xu3A
- active site: Y56 (≠ F48), K176 (≠ A168), E209 (= E203), L231 (= L227)
- binding pyridoxal-5'-phosphate: R75 (= R73), K176 (≠ A168), F183 (≠ I175), E209 (= E203), G212 (≠ S206), F213 (≠ A207), L231 (= L227), G233 (= G229), V234 (= V230), T235 (= T231), T271 (= T267)
6snlD (R)-selective amine transaminase from exophiala sideris (see paper)
26% identity, 93% coverage: 15:309/318 of query aligns to 24:313/320 of 6snlD
- active site: Y57 (≠ F48), K178 (≠ A168), E211 (= E203), L233 (= L227)
- binding pyridoxal-5'-phosphate: R76 (= R73), K178 (≠ A168), E211 (= E203), G214 (≠ S206), F215 (≠ A207), L233 (= L227), G235 (= G229), V236 (= V230), T237 (= T231), T273 (= T267)
Query Sequence
>WP_013074321.1 NCBI__GCF_000092905.1:WP_013074321.1
MSQSSAQGPSPKQEISGGYCFFKGEIIPLADANVNITTHALNYGTGCFEGIRAYWNPDQG
QLYMLKGLEHYRRLHRSCRILKIDCPYSAEELLDITVRVLQKNGYREDVYIRPLAFKAAQ
VIKVTLSGLRDEIAIFTVPMGDYVKTEGLSVVVSNWLRVADNIIPSRAKVTGAYINPALA
SDAAAADGYDEAIMLSADGQVSEASSANLFVVRDGTLVTTPVTADILEGVTRRAVITLAR
DLGIPYEIRNIDRTELYVADEMFLAGTGAQIAAITSVDRRPVGDGEVGPITRRLQEIYFR
AVRGYEDAYRDWLTPVYG
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory