SitesBLAST
Comparing WP_013136118.1 NCBI__GCF_000092245.1:WP_013136118.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
6t77A Crystal structure of klebsiella pneumoniae fabg(NADPH-dependent) NADP- complex at 1.75 a resolution (see paper)
39% identity, 99% coverage: 2:232/234 of query aligns to 4:241/244 of 6t77A
- active site: G16 (≠ S14), S138 (= S132), Y151 (= Y145)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G12 (= G10), S14 (≠ T12), R15 (≠ G13), T37 (≠ S36), L58 (≠ F57), N59 (= N58), V60 (≠ M59), A87 (= A81), G88 (= G82), I89 (= I83)
P0A2C9 3-oxoacyl-[acyl-carrier-protein] reductase FabG; 3-ketoacyl-acyl carrier protein reductase; Beta-Ketoacyl-acyl carrier protein reductase; Beta-ketoacyl-ACP reductase; EC 1.1.1.100 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
39% identity, 99% coverage: 2:232/234 of query aligns to 4:241/244 of P0A2C9
- M125 (= M119) mutation to I: Loss of the temperature-sensitive phenotype; when associated with T-223.
- A223 (≠ G215) mutation to T: Loss of the temperature-sensitive phenotype; when associated with I-125.
- S224 (≠ V216) mutation to F: Distorts the local conformation and prevent stacking around Phe-221. The S224F mutation would additionally disrupt the hydrogen bond formed between Ser-224 and Glu-226.
P0AEK2 3-oxoacyl-[acyl-carrier-protein] reductase FabG; 3-ketoacyl-acyl carrier protein reductase; Beta-Ketoacyl-acyl carrier protein reductase; Beta-ketoacyl-ACP reductase; EC 1.1.1.100 from Escherichia coli (strain K12) (see 2 papers)
39% identity, 99% coverage: 2:232/234 of query aligns to 4:241/244 of P0AEK2
- GASR 12:15 (≠ GATG 10:13) binding NADP(+)
- T37 (≠ S36) binding NADP(+)
- NV 59:60 (≠ NM 58:59) binding NADP(+)
- N86 (= N80) binding NADP(+)
- Y151 (= Y145) mutation to F: Defect in the affinity for NADPH.
- YAAAK 151:155 (≠ YSASK 145:149) binding NADP(+)
- A154 (≠ S148) mutation to T: Decreases in the thermolability of the reductase; when associated with K-233.
- K155 (= K149) mutation to A: Defect in the affinity for NADPH.
- I184 (= I178) binding NADP(+)
- E233 (= E224) mutation to K: Decreases in the thermolability of the reductase; when associated with T-154.
1q7bA The structure of betaketoacyl-[acp] reductase from e. Coli in complex with NADP+ (see paper)
39% identity, 99% coverage: 2:232/234 of query aligns to 3:240/243 of 1q7bA
- active site: G15 (≠ S14), E101 (= E96), S137 (= S132), Q147 (= Q142), Y150 (= Y145), K154 (= K149)
- binding calcium ion: E232 (= E224), T233 (≠ V225)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G11 (= G10), S13 (≠ T12), R14 (≠ G13), T36 (≠ S36), N58 (= N58), V59 (≠ M59), N85 (= N80), A86 (= A81), G87 (= G82), I88 (= I83), S137 (= S132), Y150 (= Y145), K154 (= K149), P180 (= P175), G181 (= G176), I183 (= I178)
P73574 3-oxoacyl-[acyl-carrier-protein] reductase; 3-ketoacyl-acyl carrier protein reductase; EC 1.1.1.100 from Synechocystis sp. (strain PCC 6803 / Kazusa) (see paper)
41% identity, 97% coverage: 7:233/234 of query aligns to 10:245/247 of P73574
- A14 (= A11) mutation to G: 4.2-fold increase in activity on acetoacetyl-CoA.
- P151 (≠ S140) mutation to F: 2.7-fold increase in activity on acetoacetyl-CoA.; mutation to V: 5.7-fold increase in activity on acetoacetyl-CoA.
- K160 (= K149) mutation to A: Almost no activity on acetoacetyl-CoA.
- F188 (≠ I177) mutation to Y: 3.3-fold increase in activity on acetoacetyl-CoA.
- N198 (= N188) mutation to R: 3.5-fold increase in activity on acetoacetyl-CoA.
1q7cA The structure of betaketoacyl-[acp] reductase y151f mutant in complex with NADPH fragment (see paper)
38% identity, 99% coverage: 2:232/234 of query aligns to 3:240/243 of 1q7cA
- active site: G15 (≠ S14), S137 (= S132), Q147 (= Q142), F150 (≠ Y145), K154 (= K149)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: G11 (= G10), S13 (≠ T12), R14 (≠ G13), A35 (≠ N35), T36 (≠ S36), L57 (≠ F57), N58 (= N58), V59 (≠ M59), G87 (= G82), I88 (= I83)
4iiuA Crystal structure of a putative 3-oxoacyl-[acyl-carrier protein]reductase from escherichia coli strain cft073 complexed with NADP+ at 2.1 a resolution
40% identity, 99% coverage: 3:233/234 of query aligns to 2:243/243 of 4iiuA
- active site: G13 (≠ S14), S140 (= S132), Y153 (= Y145), K157 (= K149)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G9 (= G10), S11 (≠ T12), K12 (≠ G13), G13 (≠ S14), I14 (= I15), H32 (= H33), H34 (≠ N35), D36 (≠ N37), D60 (≠ N58), V61 (≠ M59), N87 (= N80), A88 (= A81), G89 (= G82), I90 (= I83), S140 (= S132), Y153 (= Y145), K157 (= K149), P183 (= P175), G184 (= G176), I186 (= I178), T188 (≠ S180), M190 (= M182), I191 (= I183)
7emgB Carbonyl reductase variant 4 (r123c/l209p/f183y/v61k) from serratia marcescens complexed with NADP+ (see paper)
38% identity, 99% coverage: 2:232/234 of query aligns to 3:240/243 of 7emgB
4jroC Crystal structure of 3-oxoacyl-[acyl-carrier protein]reductase (fabg) from listeria monocytogenes in complex with NADP+
40% identity, 100% coverage: 1:233/234 of query aligns to 3:246/247 of 4jroC
- active site: G16 (≠ S14), S142 (= S132), Q152 (= Q142), Y155 (= Y145), K159 (= K149)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G12 (= G10), S14 (≠ T12), R15 (≠ G13), G16 (≠ S14), I17 (= I15), N35 (≠ H33), Y36 (= Y34), N37 (= N35), G38 (≠ S36), S39 (≠ N37), N63 (= N58), V64 (≠ M59), N90 (= N80), A91 (= A81), I93 (= I83), I113 (≠ T103), S142 (= S132), Y155 (= Y145), K159 (= K149), P185 (= P175), I188 (= I178), T190 (≠ S180)
3sj7A Structure of beta-ketoacetyl-coa reductase (fabg) from staphylococcus aureus complex with NADPH (see paper)
39% identity, 98% coverage: 3:232/234 of query aligns to 1:237/239 of 3sj7A
- active site: G12 (≠ S14), S138 (= S132), Q148 (= Q142), Y151 (= Y145), K155 (= K149)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: G8 (= G10), S10 (≠ T12), R11 (≠ G13), I13 (= I15), N31 (≠ H33), Y32 (= Y34), A33 (≠ N35), G34 (≠ S36), S35 (≠ N37), A58 (≠ D61), N59 (vs. gap), V60 (vs. gap), N86 (= N80), A87 (= A81), T109 (= T103), S138 (= S132), Y151 (= Y145), K155 (= K149), P181 (= P175), G182 (= G176)
3osuA Crystal structure of the 3-oxoacyl-acyl carrier protein reductase, fabg, from staphylococcus aureus
39% identity, 98% coverage: 3:232/234 of query aligns to 4:244/246 of 3osuA
9clyB Crystal structure of the 3-ketoacyl-(acyl-carrier-protein) reductase, cylg, from streptococcus agalactiae 2603v/r
40% identity, 98% coverage: 4:233/234 of query aligns to 4:240/242 of 9clyB
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: G10 (= G10), R13 (≠ G13), G14 (≠ S14), I15 (= I15), Y34 (= Y34), N35 (= N35), S36 (= S36), C56 (≠ F57), N57 (= N58), I58 (≠ M59), N84 (= N80), I135 (≠ V130), S137 (= S132), Y150 (= Y145), K154 (= K149), G181 (= G176), I183 (= I178), T185 (≠ S180), M187 (= M182)
3op4A Crystal structure of putative 3-ketoacyl-(acyl-carrier-protein) reductase from vibrio cholerae o1 biovar eltor str. N16961 in complex with NADP+ (see paper)
37% identity, 99% coverage: 1:232/234 of query aligns to 6:244/247 of 3op4A
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G15 (= G10), S17 (≠ T12), R18 (≠ G13), I20 (= I15), T40 (≠ S36), N62 (= N58), V63 (≠ M59), N89 (= N80), A90 (= A81), I92 (= I83), V139 (= V130), S141 (= S132), Y154 (= Y145), K158 (= K149), P184 (= P175), G185 (= G176), I187 (= I178), T189 (≠ S180), M191 (= M182)
4i08A Crystal structure of beta-ketoacyl-acyl carrier protein reductase (fabg) from vibrio cholerae in complex with NADPH (see paper)
38% identity, 99% coverage: 1:232/234 of query aligns to 6:240/243 of 4i08A
- active site: G19 (≠ S14), N113 (= N104), S141 (= S132), Q151 (= Q142), Y154 (= Y145), K158 (= K149)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: G15 (= G10), S17 (≠ T12), R18 (≠ G13), I20 (= I15), T40 (≠ S36), N62 (= N58), V63 (≠ M59), N89 (= N80), A90 (= A81), G140 (≠ A131), S141 (= S132), Y154 (= Y145), K158 (= K149), P184 (= P175), G185 (= G176), T189 (≠ S180)
4ag3A Crystal structure of 3-ketoacyl-(acyl-carrier-protein) reductase (fabg) from pseudomonas aeruginosa in complex with NADPH at 1.8a resolution (see paper)
38% identity, 99% coverage: 1:232/234 of query aligns to 10:251/254 of 4ag3A
- active site: G23 (≠ S14), S148 (= S132), Y161 (= Y145), K165 (= K149)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: G19 (= G10), S21 (≠ T12), R22 (≠ G13), G23 (≠ S14), I24 (= I15), T44 (≠ H33), L68 (≠ F57), D69 (≠ N58), V70 (≠ M59), N96 (= N80), A97 (= A81), I146 (≠ V130), S148 (= S132), Y161 (= Y145), K165 (= K149), P191 (= P175), G192 (= G176), F193 (≠ I177), I194 (= I178), T196 (≠ S180), M198 (= M182), T199 (≠ I183)
7caxD Crystal structure of bacterial reductase
38% identity, 99% coverage: 3:233/234 of query aligns to 1:238/238 of 7caxD
- active site: G12 (≠ S14), S139 (= S132), Y152 (= Y145)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: G8 (= G10), S10 (≠ T12), R11 (≠ G13), I13 (= I15), H31 (= H33), R33 (≠ N35), S34 (= S36), R35 (≠ N37), D59 (≠ N58), V60 (≠ M59), N86 (= N80), A87 (= A81), G88 (= G82), S139 (= S132), Y152 (= Y145), K156 (= K149), P182 (= P175), G183 (= G176), I185 (= I178)
6t62A Crystal structure of acinetobacter baumannii fabg in complex with NADPH at 1.8 a resolution (see paper)
35% identity, 99% coverage: 2:232/234 of query aligns to 4:241/244 of 6t62A
- active site: G16 (≠ S14), S138 (= S132), Y151 (= Y145)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G12 (= G10), S14 (≠ T12), R15 (≠ G13), A36 (≠ N35), T37 (≠ S36), L58 (≠ F57), D59 (≠ N58), V60 (≠ M59), N86 (= N80), A87 (= A81), G88 (= G82), I89 (= I83), I136 (≠ V130), S137 (≠ A131), S138 (= S132), Y151 (= Y145), K155 (= K149), P181 (= P175), G182 (= G176), I184 (= I178), M188 (= M182)
6wprA Crystal structure of a putative 3-oxoacyl-acp reductase (fabg) with NADP(h) from acinetobacter baumannii (see paper)
35% identity, 99% coverage: 2:232/234 of query aligns to 4:241/244 of 6wprA
- active site: G16 (≠ S14), S138 (= S132), Y151 (= Y145)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: G12 (= G10), S14 (≠ T12), R15 (≠ G13), T37 (≠ S36), L58 (≠ F57), D59 (≠ N58), V60 (≠ M59), N86 (= N80), A87 (= A81), G88 (= G82), I89 (= I83), I136 (≠ V130), Y151 (= Y145), K155 (= K149), P181 (= P175)
4bo4C Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (fabg) from pseudomonas aeruginosa in complex with n-(2-methoxyphenyl)-3,4- dihydro-2h-quinoline-1-carboxamide at 2.7a resolution (see paper)
38% identity, 99% coverage: 1:232/234 of query aligns to 16:252/255 of 4bo4C
4dmmB 3-oxoacyl-[acyl-carrier-protein] reductase from synechococcus elongatus pcc 7942 in complex with NADP
39% identity, 100% coverage: 1:233/234 of query aligns to 3:238/240 of 4dmmB
- active site: G16 (≠ S14), S142 (= S132), Q152 (= Q142), Y155 (= Y145), K159 (= K149)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G12 (= G10), S14 (≠ T12), R15 (≠ G13), G16 (≠ S14), I17 (= I15), A37 (≠ N35), S38 (= S36), S39 (≠ N37), A62 (≠ Q60), D63 (= D61), V64 (≠ K62), N90 (= N80), A91 (= A81), L113 (≠ T103), I140 (≠ V130), S142 (= S132), Y155 (= Y145), K159 (= K149), P185 (= P175), G186 (= G176), I188 (= I178), T190 (≠ S180), M192 (= M182)
Query Sequence
>WP_013136118.1 NCBI__GCF_000092245.1:WP_013136118.1
MENKKVLVTGATGSIGQAIVKEYSKNGYYVYIHYNSNKDKAQELLKDINSNGELISFNMQ
DKNSIREVLENLDVEVLVNNAGIIKDNLFFFMNDDEWEDVINTNLTGLFYVTKVISKNMM
MNKRGSIVNVASISGISGNSGQANYSASKGGVIAFTKTLSIELGRYNIRVNALAPGIIES
EMIENIPNVKELKKAIPLKRFGKAQEVAKCAYFIGVDATYVSGEVLNISGAMVR
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory