SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing WP_013256926.1 NCBI__GCF_000143965.1:WP_013256926.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

2vd3A The structure of histidine inhibited hisg from methanobacterium thermoautotrophicum
30% identity, 99% coverage: 5:291/291 of query aligns to 5:288/289 of 2vd3A

query
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2vd3A

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binding histidine: G237 (≠ S241), M238 (≠ L242), G240 (≠ A244), T242 (= T246), V258 (≠ I261)
binding magnesium ion: E24 (≠ A23), Q43 (≠ D41), D160 (≠ E162), L161 (≠ V163)

5lhtA Atp phosphoribosyltransferase from mycobacterium tuberculosis in complex with the allosteric activator 3-(2-thienyl)-l-alanine (see paper)
30% identity, 96% coverage: 5:283/291 of query aligns to 2:275/284 of 5lhtA

query
sites
5lhtA

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binding beta(2-thienyl)alanine: D216 (≠ K224), Y217 (≠ M225), D218 (≠ N226)

1nh8A Atp phosphoribosyltransferase (atp-prtase) from mycobacterium tuberculosis in complex with amp and histidine (see paper)
29% identity, 96% coverage: 5:283/291 of query aligns to 2:267/276 of 1nh8A

query
sites
1nh8A

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binding adenosine monophosphate: V155 (= V163), G157 (≠ E165), S158 (≠ T166), G159 (= G167), R160 (≠ S168), T161 (= T169)
binding histidine: D208 (≠ K224), Y209 (≠ M225), D210 (≠ N226), A265 (≠ G281), L267 (≠ I283)

5u99A Transition state analysis of adenosine triphosphate phosphoribosyltransferase (see paper)
29% identity, 96% coverage: 5:283/291 of query aligns to 4:269/278 of 5u99A

query
sites
5u99A

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binding adenosine-5'-triphosphate: D72 (= D72), S92 (≠ V92), V157 (= V163)

1z7nF Atp phosphoribosyl transferase (hiszg atp-prtase) from lactococcus lactis with bound prpp substrate (see paper)
29% identity, 64% coverage: 5:191/291 of query aligns to 2:184/205 of 1z7nF

query
sites
1z7nF

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V

D

H

Y

Y

Y

V

-

E

-

E

E

L

L

I

L

Y

Y

S

L

K

K

V

I

S

-

S

-

R

-

P

-

A

G

R

Q

W

C

V

I

L

F

A

A

V

L

D

A

K

S

E

Y

S

P

G

D

I

F

E

S

T

N

E

K

A

N

D

F

L

Q

A

R

G

H

K

K

R

R

V

I

A

A

T

S

E

K

M

Y

V

P

N

R

F

V

T

T

K

K

R

K

Y

Y

F

F

A

A

E

Q

R

K

D

Q

I

E

P

D

V

I

A

E

V

I

Q

I

F

K

S

L

W

E

G
|
G

A
x
S

T

V

E

E

A

L

K

G

V

P

V

V

N

V

G

G

L

L

A

A

D

D

A

A

I

I

V

V

E
x
D

V

I

T
x
V

E
|
E

T
|
T

G
|
G

S

N

T
|
T

I

L

R

S

A

A

H

N

G

G

L

L

K

E

I

V

I

I

K

E

E

K

L

I

M

S

Q

D

S

I

T

S

T

T

Q

R

L

M

I

I

A

V

N

N

binding 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose: G139 (= G146), S140 (≠ A147), D155 (≠ E162), V157 (≠ T164), E158 (= E165), T159 (= T166), G160 (= G167), T162 (= T169)

1z7mE Atp phosphoribosyl transferase (hiszg atp-prtase) from lactococcus lactis (see paper)
29% identity, 64% coverage: 5:191/291 of query aligns to 2:180/200 of 1z7mE

query
sites
1z7mE

L

I

K

K

L

I

G

A

I

I

P

T

K

K

G

G

S

R

L

I

Q

Q

E

K

A

Q

T

V

V

T

R

K

L

L

F

L

A

E

K

N

A

A

G

D

W

Y

R

D

I

V

N

E

V

P

N

I

G

R

R

E

S

L

Y

Q

F

I

P

K

E

T

I

K

D

D

D

D

V

L

D

Q

I

I

E

-

C

-

S

I

L

F

C

G

R

K

A

P

Q

N

E

D

M

V

S

I

L

T

Y

F

V

L

E

E

N

H

G

G

T

I

L

V

D

D

A

I

G

G

I

F

T

V

G

G

R

K

D

D

W

T

I

L

L

D

E

E

N

N

S

D

S

F

D

D

V

D

H

Y

Y

Y

V

-

E

-

E

E

L

L

I

L

Y

Y

S

L

K

K

V

I

S

-

S

-

R

-

P

-

A

G

R

Q

W

C

V

I

L

F

A

A

V

L

D

A

K

S

E

Y

S

P

G

D

I

F

E

S

T

N

E

K

A

N

D

F

L

Q

A

R

G

H

K

K

R

R

V

I

A

A

T

S

E

K

M

Y

V

P

N

R

F

V

T

T

K

K

R

K

Y

Y

F

F

A

A

E

Q

R

K

D

Q

I

E

P

D

V

I

A

E

V

I

Q

I

F

K

S

L

W

E

G

G

A

S

T

V

E

E

A

L

K

G

V

P

V

V

N

V

G

G

L

L

A

A

D

D

A

A

I

I

V

V

E

D

V

I

T

V

E
|
E

T
|
T

G
|
G

S

N

T
|
T

I

L

R

S

A

A

H

N

G

G

L

L

K

E

I

V

I

I

K

E

E

K

L

I

M

S

Q

D

S

I

T

S

T

T

Q

R

L

M

I

I

A

V

N

N

binding phosphate ion: E154 (= E165), T155 (= T166), G156 (= G167), T158 (= T169)

6fd9A Catalytic subunit hisg from psychrobacter arcticus atp phosphoribosyltransferase (hiszg atpprt) in complex with amp
29% identity, 66% coverage: 5:196/291 of query aligns to 4:190/209 of 6fd9A

query
sites
6fd9A

L

L

K

T

L

L

G

A

I

L

P

S

K

K

G

G

S
x
R

L

I

Q

L

E

E

A

E

T

T

V

M

R

P

L

L

F

L

A

R

K

A

A

A

G

G

W

V

R

E

I

L

-

L

-

E

-

D

-

P

N

E

V

A

N

S

G

R

R

K

S

L

Y

I

F

F

P

P

E

T

I

-

D

S

D

N

V

P

D

N

I

V

E

R

C

V

S

L

L

I

C

L

R

R

A

A

Q

S

E

D

M

V

S

P

L

T

Y

Y

V

V

E

E

N

H

G

G

T

A

L

A

D

D

A

F

G

G

I

V

T

A

G

G

R

K

D

D

W

V

I

L

L

L

E

E

N

H

S

G

S

A

D

N

V

-

H

-

Y

H

V

V

E

Y

E

E

L

L

I

L

Y

D

S

L

K

K

V

I

S
x
A

S

Q

R

-

P

-

A
x
C

R

K

W

L

V

M

L

T

A

A

V

G

D

V

K

K

E

D

S

A

G

P

I

L

E

P

T

N

E

R

A

R

D

-

L

-

A

-

G

-

K

L

R

R

V

I

A

A

T

T

E

K

M

Y

V

V

N

N

F

V

T

A

K

R

R

A

Y

Y

F

F

A

A

E

S

R

Q

D

G

I

Q

P

Q

V

V

A

D

V

V

Q

I

F

K

S

L

W

Y

G

G

A

S

T

M

E

E

A

L

K

A

V

P

V

L

N

V

G

G

L

L

A

G

D

D

A

L

I

I

V

V

E

D

V
|
V

T
x
V

E
x
D

T
|
T

G

G

S

N

T
|
T

I

L

R

R

A

A

H

N

G

G

L

L

K

E

I

A

I

R

K

D

E

H

L

I

M

C

Q

D

S

V

T

S

T

S

Q

R

L

L

I

I

A

V

N

N

H

Q

A

V

A

S

W

Y

R

K

binding adenosine monophosphate: R12 (≠ S13), A93 (≠ S93), C95 (≠ A97), V157 (= V163), V158 (≠ T164), D159 (≠ E165), T160 (= T166), T163 (= T169)

6fcyA Catalytic subunit hisg from psychrobacter arcticus atp phosphoribosyltransferase (hiszg atpprt) in complex with prpp and adp
29% identity, 66% coverage: 5:196/291 of query aligns to 4:190/208 of 6fcyA

query
sites
6fcyA

L

L

K

T

L

L

G

A

I

L

P

S

K

K

G

G

S
x
R

L

I

Q

L

E

E

A

E

T

T

V

M

R

P

L

L

F

L

A

R

K

A

A

A

G

G

W

V

R

E

I

L

-

L

-

E

-

D

-

P

N

E

V

A

N

S

G

R

R

K

S

L

Y

I

F

F

P

P

E

T

I

-

D

S

D

N

V

P

D

N

I

V

E

R

C

V

S

L

L

I

C

L

R

R

A

A

Q

S

E

D

M

V

S

P

L

T

Y

Y

V

V

E

E

N

H

G

G

T

A

L

A

D

D

A

F

G

G

I

V

T

A

G

G

R

K

D
|
D

W

V

I

L

L

L

E

E

N

H

S

G

S

A

D

N

V

-

H

-

Y

H

V

V

E

Y

E

E

L

L

I

L

Y

D

S

L

K

K

V

I

S
x
A

S

Q

R

-

P

-

A
x
C

R

K

W

L

V

M

L

T

A

A

V

G

D

V

K

K

E

D

S

A

G

P

I

L

E

P

T

N

E

R

A

R

D

-

L

-

A

-

G

-

K

L

R

R

V

I

A

A

T

T

E

K

M

Y

V

V

N

N

F

V

T

A

K

R

R

A

Y

Y

F

F

A

A

E

S

R

Q

D

G

I

Q

P

Q

V

V

A

D

V

V

Q

I

F

K

S

L

W

Y

G

G

A

S

T

M

E

E

A

L

K

A

V

P

V

L

N

V

G

G

L

L

A

G

D

D

A

L

I

I

V

V

E

D

V
|
V

T

V

E
x
D

T
|
T

G
|
G

S

N

T
|
T

I

L

R

R

A

A

H

N

G

G

L

L

K

E

I

A

I

R

K

D

E

H

L

I

M

C

Q

D

S

V

T

S

T

S

Q

R

L

L

I

I

A

V

N

N

H

Q

A

V

A

S

W

Y

R

K

binding adenosine-5'-diphosphate: R12 (≠ S13), D74 (= D72), A93 (≠ S93), C95 (≠ A97), V157 (= V163), D159 (≠ E165)
binding 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose: R12 (≠ S13), V157 (= V163), D159 (≠ E165), T160 (= T166), G161 (= G167), T163 (= T169)

6fcwA Catalytic subunit hisg from psychrobacter arcticus atp phosphoribosyltransferase (hiszg atpprt) in complex with pratp
29% identity, 66% coverage: 5:196/291 of query aligns to 4:190/209 of 6fcwA

query
sites
6fcwA

L

L

K

T

L

L

G

A

I

L

P

S

K

K

G

G

S
x
R

L
x
I

Q

L

E

E

A

E

T

T

V

M

R

P

L

L

F

L

A

R

K

A

A

A

G

G

W

V

R

E

I

L

-

L

-

E

-

D

-

P

N

E

V

A

N

S

G

R

R

K

S

L

Y

I

F

F

P

P

E

T

I

-

D

S

D

N

V

P

D

N

I

V

E

R

C

V

S

L

L

I

C

L

R

R

A

A

Q

S

E

D

M

V

S

P

L

T

Y

Y

V

V

E

E

N

H

G

G

T

A

L

A

D

D

A

F

G

G

I

V

T

A

G

G

R

K

D
|
D

W

V

I

L

L

L

E

E

N

H

S

G

S

A

D

N

V

-

H

-

Y

H

V

V

E

Y

E

E

L

L

I

L

Y

D

S

L

K

K

V

I

S

A

S

Q

R

-

P

-

A
x
C

R

K

W

L

V

M

L

T

A

A

V

G

D

V

K

K

E

D

S

A

G

P

I

L

E

P

T

N

E

R

A

R

D

-

L

-

A

-

G

-

K

L

R

R

V

I

A

A

T

T

E
x
K

M

Y

V

V

N

N

F

V

T

A

K

R

R

A

Y

Y

F

F

A

A

E

S

R

Q

D

G

I

Q

P

Q

V

V

A

D

V

V

Q

I

F

K

S

L

W

Y

G

G

A

S

T

M

E

E

A

L

K

A

V

P

V

L

N

V

G

G

L

L

A

G

D

D

A

L

I

I

V

V

E
x
D

V
|
V

T

V

E
x
D

T
|
T

G
|
G

S

N

T
|
T

I

L

R

R

A

A

H

N

G

G

L

L

K

E

I

A

I

R

K

D

E

H

L

I

M

C

Q

D

S

V

T

S

T

S

Q

R

L

L

I

I

A

V

N

N

H

Q

A

V

A

S

W

Y

R

K

binding phosphoribosyl atp : R12 (≠ S13), I13 (≠ L14), D74 (= D72), C95 (≠ A97), K117 (≠ E123), D156 (≠ E162), V157 (= V163), D159 (≠ E165), T160 (= T166), G161 (= G167), T163 (= T169)

6fctA Catalytic subunit hisg from psychrobacter arcticus atp phosphoribosyltransferase (hiszg atpprt) in complex with prpp and atp
29% identity, 66% coverage: 5:196/291 of query aligns to 4:190/209 of 6fctA

query
sites
6fctA

L

L

K

T

L

L

G

A

I

L

P

S

K

K

G

G

S
x
R

L

I

Q

L

E

E

A

E

T

T

V

M

R

P

L

L

F

L

A

R

K

A

A

A

G

G

W

V

R

E

I

L

-

L

-

E

-

D

-

P

N

E

V

A

N

S

G

R

R

K

S

L

Y

I

F

F

P

P

E

T

I

-

D

S

D

N

V

P

D

N

I

V

E

R

C

V

S

L

L

I

C

L

R

R

A

A

Q

S

E

D

M

V

S

P

L

T

Y

Y

V

V

E

E

N

H

G

G

T

A

L

A

D

D

A

F

G

G

I

V

T

A

G

G

R

K

D
|
D

W

V

I

L

L

L

E

E

N

H

S

G

S

A

D

N

V

-

H

-

Y

H

V

V

E

Y

E

E

L

L

I

L

Y

D

S

L

K

K

V

I

S
x
A

S

Q

R

-

P

-

A
x
C

R

K

W

L

V

M

L

T

A

A

V

G

D

V

K

K

E

D

S

A

G

P

I

L

E

P

T

N

E

R

A

R

D

-

L

-

A

-

G

-

K

L

R

R

V

I

A

A

T

T

E

K

M

Y

V

V

N

N

F

V

T

A

K

R

R

A

Y

Y

F

F

A

A

E

S

R

Q

D

G

I

Q

P

Q

V

V

A

D

V

V

Q

I

F

K

S

L

W

Y

G

G

A

S

T

M

E

E

A

L

K

A

V

P

V

L

N

V

G

G

L

L

A

G

D

D

A

L

I

I

V

V

E

D

V
|
V

T
x
V

E
x
D

T
|
T

G
|
G

S

N

T
|
T

I

L

R

R

A

A

H

N

G

G

L

L

K

E

I

A

I

R

K

D

E

H

L

I

M

C

Q

D

S

V

T

S

T

S

Q

R

L

L

I

I

A

V

N

N

H

Q

A

V

A

S

W

Y

R

K

binding adenosine-5'-triphosphate: R12 (≠ S13), D74 (= D72), A93 (≠ S93), C95 (≠ A97), V157 (= V163), D159 (≠ E165)
binding 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose: R12 (≠ S13), V157 (= V163), V158 (≠ T164), D159 (≠ E165), T160 (= T166), G161 (= G167), T163 (= T169)

6fcaA Catalytic subunit hisg from psychrobacter arcticus atp phosphoribosyltransferase (hiszg atpprt) in complex with prpp
29% identity, 66% coverage: 5:196/291 of query aligns to 4:190/209 of 6fcaA

query
sites
6fcaA

L

L

K

T

L

L

G

A

I

L

P

S

K

K

G

G

S

R

L

I

Q

L

E

E

A

E

T

T

V

M

R

P

L

L

F

L

A

R

K

A

A

A

G

G

W

V

R

E

I

L

-

L

-

E

-

D

-

P

N

E

V

A

N

S

G

R

R

K

S

L

Y

I

F

F

P

P

E

T

I

-

D

S

D

N

V

P

D

N

I

V

E

R

C

V

S

L

L

I

C

L

R

R

A

A

Q

S

E

D

M

V

S

P

L

T

Y

Y

V

V

E

E

N

H

G

G

T

A

L

A

D

D

A

F

G

G

I

V

T

A

G

G

R

K

D

D

W

V

I

L

L

L

E

E

N

H

S

G

S

A

D

N

V

-

H

-

Y

H

V

V

E

Y

E

E

L

L

I

L

Y

D

S

L

K

K

V

I

S

A

S

Q

R

-

P

-

A

C

R

K

W

L

V

M

L

T

A

A

V

G

D

V

K

K

E

D

S

A

G

P

I

L

E

P

T

N

E

R

A

R

D

-

L

-

A

-

G

-

K

L

R

R

V

I

A

A

T

T

E

K

M

Y

V

V

N

N

F

V

T

A

K

R

R

A

Y

Y

F

F

A

A

E

S

R

Q

D

G

I

Q

P

Q

V

V

A

D

V

V

Q

I

F

K

S

L

W

Y

G

G

A

S

T

M

E

E

A

L

K

A

V

P

V

L

N

V

G

G

L

L

A

G

D

D

A

L

I

I

V

V

E
x
D

V
|
V

T
x
V

E
x
D

T
|
T

G
|
G

S

N

T
|
T

I

L

R

R

A

A

H

N

G

G

L

L

K

E

I

A

I

R

K

D

E

H

L

I

M

C

Q

D

S

V

T

S

T

S

Q

R

L

L

I

I

A

V

N

N

H

Q

A

V

A

S

W

Y

R

K

binding 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose: D156 (≠ E162), V157 (= V163), V158 (≠ T164), D159 (≠ E165), T160 (= T166), G161 (= G167), T163 (= T169)

7dahC Adenosine triphosphate phosphoribosyltransferase from vibrio cholerae in complex with atp and prpp
26% identity, 99% coverage: 3:291/291 of query aligns to 2:287/288 of 7dahC

query
sites
7dahC

Q

Q

P

R

L

L

K

R

L

I

G

A

I

I

-
x
Q

P

K

K

K

G

G

S
x
R

L

L

Q

S

E

Q

A

E

T

C

V

Q

R

E

L

L

F

L

A

K

K

K

A

C

G

G

W

V

R

K

I

F

N

N

V

I

N

M

G

G

R

E

S

R

Y

L

F

V

P

V

E

H

I

S

D

L

D

N

V

M

D

P

I

I

E

D

C

L

S

L

L

L

C

V

R
|
R

A
x
D

Q
x
D

E

D

M

I

S

P

L

G

Y

L

V

I

E

M

N

D

G

G

T

V

L

V

D

D

A

L

G

G

I

F

T

V

G

G

R

E

D
x
N

W

V

I

L

L

E

E

E

N

T

S

R

S

L

D

D

V

R

H

L

Y

A

V

L

-

N

-

Q

-

R

-

N

E

E

E

F

L

T

I

T

Y

L

S

R

K

R

V

M

S

D

S

F

R

G

P
x
G

A
x
C

R

R

W

L

V

S

L

I

A

A

V

I

D

E

K

K

E

D

S

A

G

E

I

Y

E

R

T

G

E

P

A

Q

D

D

L

L

A

N

G

G

K

K

R

R

V

I

A

A

T

T

E

T

M

Y

V

P

N

Q

F

L

T

L

K

K

R

A

Y

Y

F

M

A

D

E

R

R

Q

D

G

I

V

P

D

V

F

A

S

V

T

Q

C

F

M

S

L

W

T

G
|
G

A
x
S

T

V

E
|
E

A

V

K

A

V

P

V

R

N

A

G

G

L

L

A

A

D

D

A

A

I

I

V

A

E

D

V
x
L

T

V

E
x
S

T
|
T

G
|
G

S
x
A

T
|
T

I

L

R

E

A

A

H

N

G

G

L

L

K

K

I

E

I

V

K

E

E

V

L

I

M

F

Q

E

S

S

T

K

T

A

Q

T

L

L

I

I

A

Q

N

R

H

P

A

G

A

A

W

F

R

A

D

A

D

D

E

-

K

K

R

A

A

A

K

L

I

I

S

D

Q

K

I

L

A

L

L

T

L

R

L

M

K

H

A

G

A

V

L

Q

V

Q

A

A

E

K

K

E

L

S

V

K

G

Y

L

I

K

M

M

L

N

H

V

A

P

P

K

V

I

E

K

K

F

L

Q

A

D

Q

I

I

V

K

D

T

T

L

L

L

P

P

S

G

L

A

N

E

A

D

P

P

T

T

V

V

A

-

P

P

L

L

Y

-

N

-

S

-

D

-

W

-

F

-

A

A

V

V

E

H

T

M

I

V

V

S

E

S

E

E

S

N

K

L

V

F

R

W

D

E

L

T

V

M

P

E

L

Q

L

L

I

K

A

A

R

L

G

G

A

A

E

S

G

S

I

I

I

L

E

V

Y

L

S

P

L

I

N

E

K

K

V

M

I

M

binding adenosine-5'-triphosphate: Q9 (vs. gap), R13 (≠ S13), R51 (= R51), D52 (≠ A52), D53 (≠ Q53), N72 (≠ D72), G100 (≠ P96), C101 (≠ A97), L167 (≠ V163)
binding magnesium ion: D52 (≠ A52), D53 (≠ Q53)
binding 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose: G150 (= G146), S151 (≠ A147), E153 (= E149), L167 (≠ V163), S169 (≠ E165), T170 (= T166), G171 (= G167), A172 (≠ S168), T173 (= T169)

4yb7A Adenosine triphosphate phosphoribosyltransferase from campylobacter jejuni in complex with atp (see paper)
25% identity, 99% coverage: 5:291/291 of query aligns to 4:295/296 of 4yb7A

query
sites
4yb7A

L

L

K

R

L

I

G

A

I

I

P
x
Q

K

K

-

S

G
|
G

S
x
R

L
|
L

Q

S

E

K

A

E

T

S

V

I

R

E

L

L

F

L

A

S

K

E

A

C

G

G

W

V

R

K

I

M

N

H

V

I

N

H

G

E

R

Q

S

S

Y

L

F

I

P

A

E

F

I

S

D

T

D

N

V

L

D

P

I

I

E

D

C

I

S

L

L

R

C

V

R
|
R

A
x
D

Q
x
D

E

D

M

I

S

P

L

G

Y

L

V

I

E

F

N

D

G

G

T

V

L

V

D

D

A

L

G

G

I

I

T

I

G

G

-

E

-
x
N

-

V

-

L

-

E

-

E

-

N

-

E

-

L

-

E

R

R

D

Q

W

S

I

L

L

G

E

E

N

N

S

P

S

S

D

-

V

-

H

-

Y

Y

V

K

E

-

E

-

L

-

I

L

Y

L

S

K

K

K

V

L

S

D

S

F

R
x
G

P

Y

A
x
C

R

R

W

L

V

S

L

L

A

A

V

L

D

P

K

Q

E

E

S

N

G

K

I

F

E

Q

T

N

E

L

A

K

D

D

L

F

A

E

G

G

K

L

R

R

V

I

A

A

T

T

E

S

M

Y

V

P

N

Q

F

L

T

L

K

K

R

R

Y

F

F

M

A

K

E

E

R

N

D

G

I

I

P

N

V

Y

A

K

V

N

Q

C

F

T

S

L

W

T

G

G

A

S

T

V

E

E

A

V

K

A

V

P

V

R

N

A

G

N

L

L

A

A

D

D

A

A

I

I

V

C

E

D

V
x
L

T

V

E
x
S

T

S

G

G

S

A

T

T

I

L

R

Q

A

A

H

N

G

N

L

L

K

K

I

E

I

V

K

K

E

V

L

I

M

Y

Q

E

S

S

T

R

T

A

Q

C

L

L

I

I

A

Q

N

K

H

E

A

N

A

A

W

L

R

-

D

S

D

K

E

E

K

K

R

Q

A

A

K

L

I

V

S

D

Q

K

I

I

A

M

L

L

L

R

L

V

K

A

A

G

A

V

L

M

V

Q

A

A

E

R

K

E

L

S

V

K

G

Y

L

I

K

M

M

L

N

H

V

A

P

P

K

K

I

E

K

K

F

L

Q

D

D

K

I

I

V

Q

D

A

T

L

L

L

P

P

S

G

L

V

N

E

A

R

P

P

T

T

V

I

A

L

P

P

L

L

-

A

Y

H

N

D

S

E

D

K

W

N

F

V

A

A

V

L

E

H

T

M

I

V

V

S

E

K

E

E

S

N

K

L

V

F

R

W

D

E

L

T

V

M

P

E

L

A

L

L

I

K

A

E

R

E

G

G

A

A

E

S

G

S

I

I

I

L

E

V

Y

L

S

P

L

I

N

E

K

K

V

M

I

L

binding adenosine-5'-triphosphate: Q9 (≠ P10), G12 (= G12), R13 (≠ S13), L14 (= L14), R51 (= R51), D52 (≠ A52), N72 (vs. gap), G99 (≠ R95), C101 (≠ A97), L167 (≠ V163), S169 (≠ E165)
binding magnesium ion: D52 (≠ A52), D53 (≠ Q53)

4yb6A Adenosine triphosphate phosphoribosyltransferase from campylobacter jejuni in complex with the inhibitors amp and histidine (see paper)
25% identity, 99% coverage: 5:291/291 of query aligns to 4:295/296 of 4yb6A

query
sites
4yb6A

L

L

K

R

L

I

G

A

I

I

P

Q

K

K

-

S

G

G

S

R

L

L

Q

S

E

K

A

E

T

S

V

I

R

E

L

L

F

L

A

S

K

E

A

C

G

G

W

V

R

K

I

M

N

H

V

I

N

H

G

E

R

Q

S

S

Y

L

F

I

P

A

E

F

I

S

D

T

D

N

V

L

D

P

I

I

E

D

C

I

S

L

L

R

C

V

R

R

A

D

Q

D

E

D

M

I

S

P

L

G

Y

L

V

I

E

F

N

D

G

G

T

V

L

V

D

D

A

L

G

G

I

I

T

I

G

G

-

E

-

N

-

V

-

L

-

E

-

E

-

N

-

E

-

L

-

E

R

R

D

Q

W

S

I

L

L

G

E

E

N

N

S

P

S

S

D

-

V

-

H

-

Y

Y

V

K

E

-

E

-

L

-

I

L

Y

L

S

K

K

K

V

L

S

D

S

F

R

G

P

Y

A

C

R

R

W

L

V

S

L

L

A

A

V

L

D

P

K

Q

E

E

S

N

G

K

I

F

E

Q

T

N

E

L

A

K

D

D

L

F

A

E

G

G

K

L

R

R

V

I

A

A

T

T

E

S

M

Y

V

P

N

Q

F

L

T

L

K

K

R

R

Y

F

F

M

A

K

E

E

R

N

D

G

I

I

P

N

V

Y

A

K

V

N

Q

C

F

T

S

L

W

T

G

G

A

S

T

V

E

E

A

V

K

A

V

P

V

R

N

A

G

N

L

L

A

A

D

D

A

A

I

I

V

C

E

D

V
x
L

T

V

E
x
S

T
x
S

G
|
G

S

A

T
|
T

I

L

R

Q

A

A

H

N

G

N

L

L

K

K

I

E

I

V

K

K

E

V

L

I

M

Y

Q

E

S

S

T

R

T

A

Q

C

L

L

I

I

A

Q

N

K

H

E

A

N

A

A

W

L

R

-

D

S

D

K

E

E

K

K

R

Q

A

A

K

L

I

V

S

D

Q

K

I

I

A

M

L

L

L

R

L

V

K

A

A

G

A

V

L

M

V

Q

A

A

E

R

K

E

L

S

V

K

G

Y

L

I

K

M

M

L

N
x
H

V

A

P

P

K

K

I

E

K

K

F

L

Q

D

D

K

I

I

V

Q

D

A

T

L

L

L

P

P

S
x
G

L
x
V

N

E

A
x
R

P

P

T
|
T

V

I

A

L

P

P

L

L

-

A

Y

H

N

D

S

E

D

K

W

N

F

V

A

A

V

L

E

H

T

M

I
x
V

V

S

E

K

E

E

S

N

K

L

V

F

R

W

D

E

L

T

V

M

P

E

L

A

L

L

I

K

A

E

R

E

G

G

A

A

E

S

G

S

I

I

I
x
L

E

V

Y

L

S

P

L

I

N

E

K

K

V

M

I

L

binding adenosine monophosphate: L167 (≠ V163), S169 (≠ E165), S170 (≠ T166), G171 (= G167), T173 (= T169)
binding histidine: H229 (≠ N226), G244 (≠ S241), V245 (≠ L242), R247 (≠ A244), T249 (= T246), V265 (≠ I261), L287 (≠ I283)

1usyG Atp phosphoribosyl transferase (hisg:hisz) complex from thermotoga maritima (see paper)
30% identity, 66% coverage: 5:196/291 of query aligns to 2:181/203 of 1usyG

query
sites
1usyG

L

L

K

K

L

L

G

A

I

I

P

P

K

K

G

G

S

R

L

L

Q

E

E

E

A

K

T

V

V

M

R

T

L

Y

F

L

A

K

K

K

A

T

G

G

W

V

R

-

I

-

N

-

V

I

N

F

G

E

R

R

S

E

Y

S

F

S

P

I

E

L

I

R

D

E

D

G

V

K

D

D

I

I

E

V

C

C

S

F

L

M

C

V

R

R

A

P

Q

F

E

D

M

V

S

P

L

T

Y

Y

V

L

E

V

N

H

G

G

T

V

L

A

D

D

A

I

G

G

I

F

T

C

G

G

R
x
T

D

D

W

V

I

L

L

L

E

E

N

K

S

E

S

T

D

S

V

L

H

-

Y

-

V

I

E
x
Q

E
x
P

L

F

I

F

Y

-

S

-

K

-

V

I

S

P

S

T

R

N

P

I

A

S

R

R

W

M

V

V

L

L

A

A

V

G

D

P

K

K

E

G

S

R

G

G

I

I

E

P

T

E

E

-

A

-

D

-

L

-

A

G

G

E

K

K

R

R

V

I

A

A

T

T

E

K

M

F

V

P

N

N

F

V

T

T

K

Q

R

R

Y

Y

F

C

A

E

E

S

R

K

D

G

I

W

P

H

V

C

A

R

V

I

Q

I

F

P

S

L

W

K

G

G

A

S

T

V

E

E

A

L

K

A

V

P

V

I

N

A

G

G

L

L

A

S

D

D

A

L

I

I

V

V

E

D

V

I

T

T

E

E

T

T

G

G

S

R

T

T

I

L

R

K

A

E

H

N

G

N

L

L

K

E

I

I

I

L

K

D

E

E

L

I

M

F

Q

V

S

I

T
x
R

T

T

Q
x
H

L

V

I

V

A

V

N

N

H

P

A

V

A

S

W
x
Y

R

R

binding histidine: T65 (≠ R71), Q77 (≠ E85), P78 (≠ E86), R170 (≠ T185), H172 (≠ Q187), Y180 (≠ W195)

1q1kA Structure of atp-phosphoribosyltransferase from e. Coli complexed with pr-atp (see paper)
23% identity, 96% coverage: 12:291/291 of query aligns to 11:287/288 of 1q1kA

query
sites
1q1kA

G

G

S
x
R

L

L

Q

S

E

D

A

D

T

S

V

R

R

E

L

L

F

L

A

A

K

R

A

C

G

G

W

I

R

K

I

I

N

N

V

L

N

H

G

T

R

Q

S

R

Y

L

F

I

P

A

E

M

I

A

D

E

D

N

V

M

D

P

I

I

E

D

C

I

S

L

L

R

C

V

R

R

A
x
D

Q
x
D

E

D

M

I

S

P

L

G

Y

L

V

V

E

M

N

D

G

G

T

V

L

V

D

D

A

L

G

G

I

I

T

I

G

G

R

E

D
x
N

W
x
V

I

L

L

E

E

E

-

E

-

L

-

L

-

N

-

R

-

R

-

A

N

Q

S

G

S

E

D

D

V

P

H

R

Y

Y

V

-

E

-

E

-

L

F

I

T

Y

L

S

R

K

R

V

L

S

D

S

F

R

G

P

G

A
x
C

R

R

W

L

V

S

L

L

A

A

V

T

D

P

K

V

E

D

S

E

G

A

I

W

E

D

T

G

E

P

A

L

D

S

L

L

A

N

G

G

K

K

R

R

V

I

A

A

T

T

E

S

M
x
Y

V

P

N

H

F

L

T

L

K

K

R

R

Y

Y

F

L

A

D

E

Q

R

K

D

G

I

I

P

S

V

F

A

K

V

S

Q

C

F

L

S

L

W

N

G

G

A

S

T

V

E
|
E

A

V

K

A

V

P

V

R

N

A

G

G

L

L

A

A

D

D

A

A

I

I

V

C

E

D

V
x
L

T

V

E
x
S

T
|
T

G
|
G

S
x
A

T
|
T

I

L

R

E

A

A

H

N

G

G

L

L

K

R

I

E

I

V

K

E

E

V

L

I

M

Y

Q

R

S

S

T

K

T

A

Q

C

L

L

I

I

A

Q

N

R

H

D

A

G

A

E

W

M

R

-

D

E

D

E

E

S

K

K

R

Q

A

Q

K

L

I

I

S

D

Q

K

I

L

A

L

L

T

L

R

L

I

K

Q

A

G

A

V

L

I

V

Q

A

A

E

R

K

E

L

S

V

K

G

Y

L

I

K

M

M

M

N

H

V

A

P

P

K

T

I

E

K

R

F

L

Q

D

D

E

I

V

V

I

D

A

T

L

L

L

P

P

S

G

L

A

N

E

A

R

P

P

T

T

V

I

A

L

P

P

L

L

Y

-

N

-

S

-

D

-

W

-

F

-

A

A

V

M

E

H

T

M

I

V

V

S

E

S

E

E

S

T

K

L

V

F

R

W

D

E

L

T

V

M

P

E

L

K

L

L

I

K

A

A

R

L

G

G

A

A

E

S

G

S

I

I

I

L

E

V

Y

L

S

P

L

I

N

E

K

K

V

M

I

M

binding phosphoribosyl atp : R12 (≠ S13), D51 (≠ A52), D52 (≠ Q53), N71 (≠ D72), V72 (≠ W73), C100 (≠ A97), Y127 (≠ M124), E152 (= E149), L166 (≠ V163), S168 (≠ E165), T169 (= T166), G170 (= G167), A171 (≠ S168), T172 (= T169)

1h3dA Structure of the e.Coli atp-phosphoribosyltransferase (see paper)
23% identity, 96% coverage: 12:291/291 of query aligns to 11:287/288 of 1h3dA

query
sites
1h3dA

G

G

S
x
R

L

L

Q

S

E

D

A

D

T

S

V

R

R

E

L

L

F

L

A

A

K

R

A

C

G

G

W

I

R

K

I

I

N

N

V

L

N

H

G

T

R

Q

S

R

Y

L

F

I

P

A

E

M

I

A

D

E

D

N

V

M

D

P

I

I

E

D

C

I

S

L

L

R

C

V

R

R

A

D

Q

D

E

D

M

I

S

P

L

G

Y

L

V

V

E

M

N

D

G

G

T

V

L

V

D

D

A

L

G

G

I

I

T

I

G

G

R

E

D

N

W

V

I

L

L

E

E

E

-

E

-

L

-

L

-

N

-

R

-

R

-

A

N

Q

S

G

S

E

D

D

V

P

H

R

Y

Y

V

-

E

-

E

-

L

F

I

T

Y

L

S

R

K

R

V

L

S

D

S

F

R

G

P

G

A

C

R

R

W

L

V

S

L

L

A

A

V

T

D

P

K

V

E

D

S

E

G

A

I

W

E

D

T

G

E

P

A

L

D

S

L

L

A

N

G

G

K

K

R

R

V

I

A

A

T

T

E

S

M

Y

V

P

N

H

F

L

T

L

K

K

R

R

Y

Y

F

L

A

D

E

Q

R

K

D

G

I

I

P

S

V

F

A

K

V

S

Q

C

F

L

S

L

W

N

G

G

A

S

T

V

E
|
E

A

V

K

A

V

P

V

R

N

A

G

G

L

L

A

A

D

D

A

A

I

I

V

C

E
x
D

V
x
L

T

V

E
x
S

T
|
T

G
|
G

S
x
A

T
|
T

I

L

R

E

A

A

H

N

G

G

L

L

K

R

I

E

I

V

K

E

E

V

L

I

M

Y

Q

R

S

S

T

K

T

A

Q

C

L

L

I

I

A

Q

N

R

H

D

A

G

A

E

W

M

R

-

D

E

D

E

E

S

K

K

R

Q

A

Q

K

L

I

I

S

D

Q

K

I

L

A

L

L

T

L

R

L

I

K

Q

A

G

A

V

L

I

V

Q

A

A

E

R

K

E

L

S

V

K

G

Y

L

I

K

M

M

M

N

H

V

A

P

P

K

T

I

E

K

R

F

L

Q

D

D

E

I

V

V

I

D

A

T

L

L

L

P

P

S

G

L

A

N

E

A

R

P

P

T

T

V

I

A

L

P

P

L

L

Y

-

N

-

S

-

D

-

W

-

F

-

A

A

V

M

E

H

T

M

I

V

V

S

E

S

E

E

S

T

K

L

V

F

R

W

D

E

L

T

V

M

P

E

L

K

L

L

I

K

A

A

R

L

G

G

A

A

E

S

G

S

I

I

I

L

E

V

Y

L

S

P

L

I

N

E

K

K

V

M

I

M

binding adenosine monophosphate: R12 (≠ S13), E152 (= E149), D165 (≠ E162), L166 (≠ V163), S168 (≠ E165), T169 (= T166), G170 (= G167), A171 (≠ S168), T172 (= T169)

4yb7C Adenosine triphosphate phosphoribosyltransferase from campylobacter jejuni in complex with atp (see paper)
25% identity, 99% coverage: 5:291/291 of query aligns to 4:293/294 of 4yb7C

query
sites
4yb7C

L

L

K

R

L

I

G

A

I

I

P
x
Q

K

K

-

S

G
|
G

S
x
R

L

L

Q

S

E

K

A

E

T

S

V

I

R

E

L

L

F

L

A

S

K

E

A

C

G

G

W

V

R

K

I

M

N

H

V

I

N

H

G

E

R

Q

S

S

Y

L

F

I

P

A

E

F

I

S

D

T

D

N

V

L

D

P

I

I

E

D

C

I

S

L

L

R

C

V

R
|
R

A
x
D

Q
x
D

E

D

M

I

S

P

L

G

Y

L

V

I

E

F

N

D

G

G

T

V

L

V

D

D

A

L

G

G

I

I

T

I

G

G

-

E

-
x
N

-

V

-

L

-

E

-

E

-

N

-

E

-

L

-

E

R

R

D

Q

W

S

I

L

L

G

E

E

N

N

S

P

S

S

D

-

V

-

H

-

Y

Y

V

K

E

-

E

-

L

-

I

L

Y

L

S

K

K

K

V

L

S

D

S

F

R

G

P

Y

A
x
C

R

R

W

L

V

S

L

L

A

A

V

L

D

P

K

Q

E

E

S

N

G

K

I

F

E

Q

T

N

E

L

A

K

D

D

L

F

A

E

G

G

K

L

R

R

V

I

A

A

T

T

E

S

M

Y

V

P

N

Q

F

L

T

L

K

K

R

R

Y

F

F

M

A

K

E

E

R

N

D

G

I

I

P

N

V

Y

A

K

V

N

Q

C

F

T

S

L

W

T

G

G

A

S

T

V

E

E

A

V

K

A

V

P

V

R

N

A

G

N

L

L

A

A

D

D

A

A

I

I

V

C

E

D

V
x
L

T
x
V

E
x
S

T
x
S

G
|
G

S

A

T
|
T

I

L

R

Q

A

A

H

N

G

N

L

L

K

K

I

E

I

V

K

K

E

V

L

I

M

Y

Q

E

S

S

T

R

T

A

Q

C

L

L

I

I

A

Q

N

K

H

E

A

N

A

A

W

L

R

-

D

S

D

K

E

E

K

K

R

Q

A

A

K

L

I

V

S

D

Q

K

I

I

A

M

L

L

L

R

L

V

K

A

A

G

A

V

L

M

V

Q

A

A

E

R

K

E

L

S

V

K

G

Y

L

I

K

M

M

L

N

H

V

A

P

P

K

K

I

E

K

K

F

L

Q

D

D

K

I

I

V

Q

D

A

T

L

L

L

P

P

S

G

L

V

N

E

A

R

P

P

T

T

V

I

A

L

P

P

L

L

Y

-

N

D

S

E

D

K

W

N

F

V

A

A

V

L

E

H

T

M

I

V

V

S

E

K

E

E

S

N

K

L

V

F

R

W

D

E

L

T

V

M

P

E

L

A

L

L

I

K

A

E

R

E

G

G

A

A

E

S

G

S

I

I

I

L

E

V

Y

L

S

P

L

I

N

E

K

K

V

M

I

L

binding adenosine-5'-triphosphate: Q9 (≠ P10), G12 (= G12), R13 (≠ S13), R51 (= R51), D52 (≠ A52), N72 (vs. gap), C101 (≠ A97), L167 (≠ V163), S169 (≠ E165)
binding magnesium ion: D52 (≠ A52), D53 (≠ Q53)
binding phosphate ion: V168 (