SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing WP_013257191.1 NCBI__GCF_000143965.1:WP_013257191.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

4ij6A Crystal structure of a novel-type phosphoserine phosphatase mutant (h9a) from hydrogenobacter thermophilus tk-6 in complex with l-phosphoserine (see paper)
32% identity, 78% coverage: 26:194/217 of query aligns to 18:184/207 of 4ij6A

query
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4ij6A

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active site: R58 (= R66), E82 (= E92), H150 (= H160)
binding phosphoserine: Q21 (≠ Y29), R58 (= R66), E82 (= E92), H85 (≠ L95), H150 (= H160), T151 (≠ S161)

Sites not aligning to the query:

active site: 8, 9, 15
binding phosphoserine: 8

1h2fA Bacillus stearothermophilus phoe (previously known as yhfr) in complex with trivanadate (see paper)
33% identity, 79% coverage: 10:180/217 of query aligns to 2:170/207 of 1h2fA

query
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1h2fA

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active site: R8 (= R16), H9 (= H17), N15 (≠ V23), R58 (= R66), E82 (= E92), H150 (= H160)
binding phosphate ion: T2 (= T10), T3 (≠ R11), G142 (= G152), E143 (≠ G153)
binding trivanadate: R8 (= R16), H9 (= H17), N15 (≠ V23), Q21 (≠ Y29), R58 (= R66), E82 (= E92), H150 (= H160), G151 (≠ S161), V152 (≠ G162)

Sites not aligning to the query:

binding phosphate ion: 1

1h2eA Bacillus stearothermophilus phoe (previously known as yhfr) in complex with phosphate (see paper)
33% identity, 79% coverage: 10:180/217 of query aligns to 2:170/207 of 1h2eA

query
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1h2eA

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active site: R8 (= R16), H9 (= H17), N15 (≠ V23), R58 (= R66), E82 (= E92), H150 (= H160)
binding phosphate ion: R8 (= R16), H9 (= H17), R58 (= R66), E82 (= E92), H150 (= H160)

5hr5A Bovine heart 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (pfkfb2) (see paper)
32% identity, 80% coverage: 9:182/217 of query aligns to 222:397/424 of 5hr5A

query
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5hr5A

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active site: R230 (= R16), H231 (= H17), N237 (≠ V23), R280 (= R66), E300 (= E92), H365 (= H160)
binding 6-O-phosphono-beta-D-fructofuranose: H231 (= H17), I242 (≠ V28), G243 (≠ Y29), E300 (= E92), Y311 (≠ F103), R325 (= R117), K329 (≠ L121), Y340 (≠ L132), Q366 (≠ S161), R370 (= R165)

Sites not aligning to the query:

binding adenosine-5'-diphosphate: 22, 23, 24, 25, 26, 27, 130, 141, 144, 145, 146, 402
binding citrate anion: 49, 52, 76, 103, 104, 171

P26285 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2; 6PF-2-K/Fru-2,6-P2ase 2; PFK/FBPase 2; 6PF-2-K/Fru-2,6-P2ase heart-type isozyme; EC 2.7.1.105; EC 3.1.3.46 from Bos taurus (Bovine) (see paper)
33% identity, 80% coverage: 9:182/217 of query aligns to 249:424/531 of P26285

query
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P26285

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Sites not aligning to the query:

467 modified: Phosphoserine; by PKA
476 modified: Phosphothreonine; by AMPK and PKC

1k6mA Crystal structure of human liver 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase (see paper)
31% identity, 74% coverage: 12:172/217 of query aligns to 215:366/432 of 1k6mA

query
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1k6mA

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active site: R219 (= R16), H220 (= H17), N226 (≠ V23), R269 (= R66), E289 (= E92), H354 (= H160)

Sites not aligning to the query:

binding phosphothiophosphoric acid-adenylate ester: 13, 14, 15, 16, 17, 18, 92, 120, 131, 134, 135, 136, 184, 210

P07953 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1; 6PF-2-K/Fru-2,6-P2ase 1; PFK/FBPase 1; 6PF-2-K/Fru-2,6-P2ase liver isozyme; EC 2.7.1.105; EC 3.1.3.46 from Rattus norvegicus (Rat) (see 3 papers)
30% identity, 77% coverage: 12:179/217 of query aligns to 254:412/471 of P07953

query
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P07953

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K

I

V

Y

W

S

T

S

S

D

H

L

M

S

K

R

R

S

T

L

I

T

Q

T

T

A

A

E

E

A

A

V

L

G

G

R

V

A

P

Q

Y

K

E

A

Q

R

-

L

-

R

-

P

-

V

-

A

-

V

W

R

K

E

A

L

L

R

N

E
|
E

L

I

N

D

L

A

G

G

V

V

W

C

E

E

G

E

L

M

T

T

F
x
Y

K

E

E

E

I

I

M

Q

E

E

K

H

Y

Y

P

P

D

E

A

E

L
x
F

K
x
A

A
x
L

R
|
R

Y

D

E

Q

D

D

L
x
K

A

Y

N

R

F

Y

K

R

I

Y

D

P

G

K

G

G

E

E

S

S

L
x
Y

E

E

E

D

M

L

S

V

R

Q

R

R

V

L

M

E

P

P

A

V

F

-

E

-

Q

-

I

I

V

M

A

E

D

L

H

E

R

R

G

Q

G

E

E

N

V

V

C

L

V

V

V

I

S

C

H

H

S
x
Q

G
x
A

V
|
V

N
x
M

R
|
R

I

C

L

L

T

A

R

Y

M

F

L

L

G

D

A

K

P

S

L

S

D

D

R

E

I

L

H259 (= H17) active site, Tele-phosphohistidine intermediate
G271 (≠ Y29) binding
E328 (= E92) active site, Proton donor/acceptor
Y339 (≠ F103) binding
FALR 350:353 (≠ LKAR 114:117) binding
R353 (= R117) binding
K357 (≠ L121) binding
Y368 (≠ L132) binding
Q394 (≠ S161) binding
QAVMR 394:398 (≠ SGVNR 161:165) binding
R398 (= R165) binding

Sites not aligning to the query:

1 modified: Initiator methionine, Removed
2 modified: N-acetylserine
33 modified: Phosphoserine; by PKA

P16118 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1; 6PF-2-K/Fru-2,6-P2ase 1; PFK/FBPase 1; 6PF-2-K/Fru-2,6-P2ase liver isozyme; EC 2.7.1.105; EC 3.1.3.46 from Homo sapiens (Human) (see paper)
30% identity, 77% coverage: 12:179/217 of query aligns to 254:412/471 of P16118

query
sites
P16118

V

I

Y

Y

L

L

W

C

R

R

H

H

P

G

E

E

V

S

R

E

G

L

V

N

A

I

D

R

G

G

R

R

V

I

Y

G

G

G

N

-

M

-

D

D

V

S

G

G

L

L

T

S

P

V

R

R

G

G

Q

K

R

Q

Q

Y

V

A

A

Y

L

A

V

L

A

A

E

N

R

F

M

I

A

Q

E

S

T

Q

R

G

L

I

D

S

A

S

-

L

-

K

I

V

Y

W

S

T

S

S

D

H

L

M

S

K

R

R

S

T

L

I

T

Q

T

T

A

A

E

E

A

A

V

L

G

G

R

V

A

P

Q

Y

K

E

A

Q

R

W

L

-

R

-

P

-

V

-

A

-

V

-

R

K

E

A

L

L

R

N

E

E

L

I

N

D

L

A

G

G

V

V

W

C

E

E

G

E

L

M

T

T

F

Y

K

E

E

E

I

I

M

Q

E

E

K

H

Y

Y

P

P

D

E

A

E

L

F

K

A

A

L

R

R

Y

D

E

Q

D

D

L

K

A

Y

N

R

F

Y

K

R

I

Y

D

P

G

K

G

G

E

E

S

S

L

Y

E

E

E

D

M

L

S

V

R

Q

R

R

V

L

M

E

P

P

A

V

F

-

E

-

Q

-

I

I

V

M

A

E

D

L

H

E

R

R

G

Q

G

E

E

N

V

V

C

L

V

V

V

I

S

C

H

H

S

Q

G

A

V

V

N

M

R

R

I

C

L

L

T

A

R

Y

M

F

L

L

G

D

A

K

P

S

L

S

D

D

R

E

I

L

Sites not aligning to the query:

49:57 binding
170:175 binding
430 binding

5htkA Human heart 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (pfkfb2) (see paper)
28% identity, 79% coverage: 12:182/217 of query aligns to 222:393/425 of 5htkA

query
sites
5htkA

V

I

Y

Y

L

L

W

C

R
|
R

H
|
H

P

G

E

E

V

S

R

E

G

F

V
x
N

A

L

D

L

G

G

R

K

V
x
I

Y
x
G

G

G

N

-

M

-

D

D

V

S

G

G

L

L

T

S

P

V

R

R

G

G

Q

K

R

Q

Q

F

V

A

A

Q

L

A

V

L

A

R

E

K

R

F

M

L

A

E

E

E

T

Q

R

E

L

I

D

T

-

D

-

L

A

K

I

V

Y

W

S

T

S

S

D

Q

L

L

S

K

R
|
R

S

T

L

I

T

Q

T

T

A

A

E

E

A

S

V

L

G

G

R

V

A

P

Q

Y

K

E

A

Q

R

W

L

-

R

-

P

-

V

-

A

-

V

-

R

K

E

I

L

L

R

N

E
|
E

L

I

N

D

L

A

G

G

V

V

W

C

E

E

G

E

L

M

T

T

F
x
Y

K

A

E

E

I

I

M

E

E

K

K

R

Y

Y

P

P

D

E

A

E

L

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A

A

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R

Y

D

E

Q

D

E

L
x
K

A

Y

N

L

F

Y

K

R

I

Y

D

P

G

G

E

E

S

S

L
x
Y

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Q

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D

M

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Q

R

R

V

L

M

E

P

P

A

V

F

I

E

M

Q

E

I

L

V

-

A

-

D

-

H

E

R

R

G

Q

G

G

E

N

V

V

C

L

V

V

V

I

S

S

H
|
H

S
x
Q

G

A

V

V

N

M

R
|
R

I

C

L

L

T

A

R

Y

M

F

L

L

G

D

-

K

-

G

-

A

-

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-

E

-

L

-

P

-

Y

-

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T

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F

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K

I

L

active site: R226 (= R16), H227 (= H17), N233 (≠ V23), R276 (= R66), E296 (= E92), H361 (= H160)
binding 6-O-phosphono-beta-D-fructofuranose: H227 (= H17), I238 (≠ V28), G239 (≠ Y29), E296 (= E92), Y307 (≠ F103), R321 (= R117), K325 (≠ L121), Y336 (≠ L132), Q362 (≠ S161), R366 (= R165)

Sites not aligning to the query:

binding adenosine-5'-triphosphate: 17, 18, 19, 20, 21, 22, 140, 144, 145, 146, 397, 398
binding citrate anion: 48, 61, 72, 99, 100, 167

O60825 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2; 6PF-2-K/Fru-2,6-P2ase 2; PFK/FBPase 2; 6PF-2-K/Fru-2,6-P2ase heart-type isozyme; EC 2.7.1.105; EC 3.1.3.46 from Homo sapiens (Human) (see 2 papers)
30% identity, 79% coverage: 12:182/217 of query aligns to 252:423/505 of O60825

query
sites
O60825

V

I

Y

Y

L

L

W

C

R

R

H

H

P

G

E

E

V

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R

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G

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Y

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G

G

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-

M

-

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D

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G

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R

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G

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Q

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A

A

Q

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A

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L

A

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K

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F

M

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A

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-

D

-

L

A

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A

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A

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L

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R

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P

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-

A

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I

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N

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A

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P

A

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M

Q

E

I

L

V

-

A

-

D

-

H

E

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N

V

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G

A

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R

I

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R

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M

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L

-

D

-

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G

A

A

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D

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E

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Y

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R

-

C

P

P

L

L

D

H

R

T

I

I

F

F

R

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I

L

Sites not aligning to the query:

466 modified: Phosphoserine; by AMPK; S→E: Constitutively active mutant that cannot be phosphorylated and further activated by AMPK.
468 modified: Phosphothreonine
483 modified: Phosphoserine; by BRAF
486 modified: Phosphoserine
493 modified: Phosphoserine

1tipA The bisphosphatase domain of the bifunctional rat liver 6- phosphofructo-2-kinase/fructose-2,6-bisphosphatase (see paper)
30% identity, 77% coverage: 12:179/217 of query aligns to 4:162/191 of 1tipA

query
sites
1tipA

V

I

Y

Y

L

L

W

C

R
|
R

H
|
H

P

G

E

E

V

S

R

E

G

L

V
x
N

A

L

D

R

G

G

R

R

V
x
I

Y

G

G

G

N

-

M

-

D

D

V

S

G

G

L

L

T

S

P

A

R

R

G

G

Q

K

R

Q

Q

Y

V

A

A

Y

L

A

V

L

A

A

E

N

R

F

M

I

A

R

E

S

T

Q

R

G

L

I

D

S

A

S

-

L

-

K

I

V

Y

W

S

T

S

S

D

H

L

M

S

K

R
|
R

S

T

L

I

T

Q

T

T

A

A

E

E

A

A

V

L

G

G

R

V

A

P

Q

Y

K

E

A

Q

R

W

L

-

R

-

P

-

V

-

A

-

V

-

R

K

E

A

L

L

R

N

E
|
E

L

I

N

D

L

A

G

G

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V

W

C

E

E

G

E

L

M

T

T

F
x
Y

K

E

E

E

I

I

M

Q

E

E

K

H

Y

Y

P

P

D

E

A

E

L

F

K

A

A

L

R
|
R

Y

D

E

Q

D

D

L
x
K

A

Y

N

R

F

Y

K

R

I

Y

D

P

G

K

G

G

E

E

S

S

L
x
Y

E

E

E

D

M

L

S

V

R

Q

R

R

V

L

M

E

P

P

A

V

F

-

E

-

Q

-

I

I

V

M

A

E

D

L

H

E

R

R

G

Q

G

E

E

N

V

V

C

L

V

V

V

I

S

C

H
|
H

S

Q

G

A

V

V

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M

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|
R

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L

L

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L

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S

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D

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L

active site: R8 (= R16), H9 (= H17), N15 (≠ V23), R58 (= R66), E78 (= E92), H143 (= H160)
binding 6-O-phosphono-beta-D-fructofuranose: I20 (≠ V28), Y89 (≠ F103), R103 (= R117), K107 (≠ L121), Y118 (≠ L132), R148 (= R165)

1c81A Michaelis complex of fructose-2,6-bisphosphatase
30% identity, 77% coverage: 12:179/217 of query aligns to 4:162/191 of 1c81A

query
sites
1c81A

V

I

Y

Y

L

L

W

C

R
|
R

H
|
H

P

G

E

E

V

S

R

E

G

L

V
x
N

A

L

D

R

G

G

R

R

V
x
I

Y

G

G

G

N

-

M

-

D

D

V

S

G

G

L

L

T

S

P

A

R

R

G

G

Q

K

R

Q

Q

Y

V

A

A

Y

L

A

V

L

A

A

E

N

R

F

M

I

A

R

E

S

T

Q

R

G

L

I

D

S

A

S

-

L

-

K

I

V

Y

W

S

T

S

S

D

H

L

M

S

K

R
|
R

S

T

L

I

T

Q

T

T

A

A

E

E

A

A

V

L

G

G

R

V

A

P

Q

Y

K

E

A

Q

R

W

L

-

R

-

P

-

V

-

A

-

V

-

R

K

E

A

L

L

R

N

E
|
E

L

I

N

D

L

A

G

G

V

V

W

C

E

E

G

E

L

M

T

T

F

Y

K

E

E

E

I

I

M

Q

E

E

K

H

Y

Y

P

P

D

E

A

E

L

F

K

A

A

L

R

R

Y

D

E

Q

D

D

L

K

A

Y

N

R

F

Y

K

R

I

Y

D

P

G

K

G

G

E

E

S

S

L

Y

E

E

E

D

M

L

S

V

R

Q

R

R

V

L

M

E

P

P

A

V

F

-

E

-

Q

-

I

I

V

M

A

E

D

L

H

E

R

R

G

Q

G

E

E

N

V

V

C

L

V

V

V

I

S

C

H
|
H

S
x
Q

G

A

V

V

N

M

R
|
R

I

C

L

L

T

A

R

Y

M

F

L

L

G

D

A

K

P

S

L

S

D

D

R

E

I

L

active site: R8 (= R16), H9 (= H17), N15 (≠ V23), R58 (= R66), E78 (= E92), H143 (= H160)
binding 2,5-anhydro-1-deoxy-1-phosphono-6-O-phosphono-D-glucitol: R8 (= R16), H9 (= H17), N15 (≠ V23), I20 (≠ V28), R58 (= R66), E78 (= E92), H143 (= H160), Q144 (≠ S161), R148 (= R165)

1c80A Regulatory complex of fructose-2,6-bisphosphatase
30% identity, 77% coverage: 12:179/217 of query aligns to 4:162/191 of 1c80A

query
sites
1c80A

V

I

Y

Y

L

L

W

C

R
|
R

H
|
H

P

G

E

E

V

S

R

E

G

L

V
x
N

A

L

D

R

G

G

R

R

V
x
I

Y

G

G

G

N

-

M

-

D

D

V

S

G

G

L

L

T

S

P

A

R

R

G

G

Q

K

R

Q

Q

Y

V

A

A

Y

L

A

V

L

A

A

E

N

R

F

M

I

A

R

E

S

T

Q

R

G

L

I

D

S

A

S

-

L

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K

I

V

Y

W

S

T

S

S

D

H

L

M

S

K

R
|
R

S

T

L

I

T

Q

T

T

A

A

E

E

A

A

V

L

G

G

R

V

A

P

Q

Y

K

E

A

Q

R

W

L

-

R

-

P

-

V

-

A

-

V

-

R

K

E

A

L

L

R

N

E
|
E

L
x
I

N

D

L

A

G

G

V

V

W

C

E

E

G

E

L

M

T

T

F
x
Y

K

E

E

E

I

I

M

Q

E

E

K

H

Y

Y

P

P

D

E

A

E

L
x
F

K

A

A

L

R
|
R

Y

D

E

Q

D

D

L

K

A

Y

N

R

F

Y

K

R

I
x
Y

D

P

G

K

G

G

E

E

S

S

L
x
Y

E

E

E

D

M

L

S

V

R

Q

R

R

V

L

M

E

P

P

A

V

F

-

E

-

Q

-

I

I

V

M

A

E

D

L

H

E

R

R

G

Q

G

E

E

N

V

V

C

L

V

V

V

I

S

C

H
|
H

S
x
Q

G
x
A

V

V

N

M

R
|
R

I

C

L

L

T

A

R

Y

M

F

L

L

G

D

A

K

P

S

L

S

D

D

R

E

I

L

active site: R8 (= R16), H9 (= H17), N15 (≠ V23), R58 (= R66), E78 (= E92), H143 (= H160)
binding guanosine-5'-triphosphate: I20 (≠ V28), E78 (= E92), I79 (≠ L93), Y89 (≠ F103), F100 (≠ L114), R103 (= R117), Y112 (≠ I126), Y118 (≠ L132), Q144 (≠ S161), A145 (≠ G162), R148 (= R165)

1c7zA Regulatory complex of fructose-2,6-bisphosphatase
30% identity, 77% coverage: 12:179/217 of query aligns to 4:162/191 of 1c7zA

query
sites
1c7zA

V

I

Y

Y

L

L

W

C

R
|
R

H
|
H

P

G

E

E

V

S

R

E

G

L

V
x
N

A

L

D

R

G

G

R

R

V

I

Y

G

G

G

N

-

M

-

D

D

V

S

G

G

L

L

T

S

P

A

R

R

G

G

Q

K

R

Q

Q

Y

V

A

A

Y

L

A

V

L

A

A

E

N

R

F

M

I

A

R

E

S

T

Q

R

G

L

I

D

S

A

S

-

L

-

K

I

V

Y

W

S

T

S

S

D

H

L

M

S

K

R
|
R

S

T

L

I

T

Q

T

T

A

A

E

E

A

A

V

L

G

G

R

V

A

P

Q

Y

K

E

A

Q

R

W

L

-

R

-

P

-

V

-

A

-

V

-

R

K

E

A

L

L

R

N

E
|
E

L

I

N

D

L

A

G

G

V

V

W

C

E

E

G

E

L

M

T

T

F
x
Y

K

E

E

E

I

I

M

Q

E

E

K

H

Y

Y

P

P

D

E

A

E

L

F

K

A

A

L

R
|
R

Y

D

E

Q

D

D

L
x
K

A

Y

N

R

F

Y

K

R

I

Y

D

P

G

K

G

G

E

E

S

S

L
x
Y

E

E

E

D

M

L

S

V

R

Q

R

R

V

L

M

E

P

P

A

V

F

-

E

-

Q

-

I

I

V

M

A

E

D

L

H

E

R

R

G

Q

G

E

E

N

V

V

C

L

V

V

V

I

S

C

H
|
H

S
x
Q

G
x
A

V

V

N

M

R
|
R

I

C

L

L

T

A

R

Y

M

F

L

L

G

D

A

K

P

S

L

S

D

D

R

E

I

L

active site: R8 (= R16), H9 (= H17), N15 (≠ V23), R58 (= R66), E78 (= E92), H143 (= H160)
binding glyceraldehyde-3-phosphate: Y89 (≠ F103), R103 (= R117), K107 (≠ L121), Y118 (≠ L132), Q144 (≠ S161), A145 (≠ G162), R148 (= R165)

1fbtA The bisphosphatase domain of the bifunctional rat liver 6- phosphofructo-2-kinase/fructose-2,6-bisphosphatase (see paper)
30% identity, 77% coverage: 12:179/217 of query aligns to 3:161/190 of 1fbtA

query
sites
1fbtA

V

I

Y

Y

L

L

W

C

R
|
R

H
|
H

P

G

E

E

V

S

R

E

G

L

V
x
N

A

L

D

R

G

G

R

R

V

I

Y

G

G

G

N

-

M

-

D

D

V

S

G

G

L

L

T

S

P

A

R

R

G

G

Q

K

R

Q

Q

Y

V

A

A

Y

L

A

V

L

A

A

E

N

R

F

M

I

A

R

E

S

T

Q

R

G

L

I

D

S

A

S

-

L

-

K

I

V

Y

W

S

T

S

S

D

H

L

M

S

K

R
|
R

S

T

L

I

T

Q

T

T

A

A

E

E

A

A

V

L

G

G

R

V

A

P

Q

Y

K

E

A

Q

R

-

L

-

R

-

P

-

V

-

A

-

V

W

R

K

E

A

L

L

R

N

E
|
E

L

I

N

D

L

A

G

G

V

V

W

C

E

E

G

E

L

M

T

T

F

Y

K

E

E

E

I

I

M

Q

E

E

K

H

Y

Y

P

P

D

E

A

E

L

F

K

A

A

L

R

R

Y

D

E

Q

D

D

L

K

A

Y

N

R

F

Y

K

R

I

Y

D

P

G

K

G

G

E

E

S

S

L

Y

E

E

E

D

M

L

S

V

R

Q

R

R

V

L

M

E

P

P

A

V

F

-

E

-

Q

-

I

I

V

M

A

E

D

L

H

E

R

R

G

Q

G

E

E

N

V

V

C

L

V

V

V

I

S

C

H
|
H

S
x
Q

G

A

V

V

N

M

R

R

I

C

L

L

T

A

R

Y

M

F

L

L

G

D

A

K

P

S

L

S

D

D

R

E

I

L

active site: R7 (= R16), H8 (= H17), N14 (≠ V23), R57 (= R66), E77 (= E92), H142 (= H160)
binding phosphate ion: R7 (= R16), H8 (= H17), R57 (= R66), E77 (= E92), H142 (= H160), Q143 (≠ S161)

4ma4A S-glutathionylated pfkfb3 (see paper)
31% identity, 74% coverage: 12:172/217 of query aligns to 239:390/444 of 4ma4A

query
sites
4ma4A

V

I

Y

Y

L

L

W

C

R
|
R

H
|
H

P

G

E

E

V

N

R

E

G

H

V
x
N

A

L

D

Q

G

G

R

R

V

I

Y
x
G

G

G

N

-

M

-

D

D

V

S

G

G

L

L

T

S

P

S

R

R

G

G

Q

K

R

K

Q

F

V

A

A

S

L

A

V

L

A

S

E

K

R

F

M

V

A

E

E

E

T

Q

R

N

L

L

D

K

A

D

-

L

-

R

I

V

Y

W

S

T

S

S

D

Q

L

L

S

K

R
x
S

S

T

L

I

T

Q

T

T

A

A

E

E

A

A

V

L

G

-

R

-

A

-

Q

-

K

-

A

-

R

R

L

L

R

P

P

Y

V

E

A

Q

V

W

R

K

E

A

L

L

R

N

E
|
E

L

I

N

D

L

A

G

G

V

V

W

C

E

E

G

E

L

L

T

T

F
x
Y

K

E

E

E

I

I

M

R

E

D

K

T

Y

Y

P

P

D

E

A

E

L

Y

K

A

A

L

R
|
R

Y

E

E

Q

D

D

L
x
K

A

Y

N

Y

F

Y

K

R

I

Y

D

P

G

T

G

G

E

E

S

S

L
x
Y

E

Q

E

D

M

L

S

V

R

Q

R

R

V

L

M

E

P

P

A

V

F

I

E

M

Q

E

I

L

V

-

A

-

D

-

H

E

R

R

G

Q

G

E

E

N

V

V

C

L

V

V

V

I

S

C

H
|
H

S
x
Q

G

A

V

V

N

L

R
|
R

I

C

L

L

T

A

R

Y

M

F

L

L

active site: R243 (= R16), H244 (= H17), N250 (≠ V23), S293 (≠ R66), E313 (= E92), H378 (= H160)
binding 6-O-phosphono-beta-D-fructofuranose: G256 (≠ Y29), E313 (= E92), Y324 (≠ F103), R338 (= R117), K342 (≠ L121), Y353 (≠ L132), Q379 (≠ S161), R383 (= R165)

Sites not aligning to the query:

binding adenosine-5'-diphosphate: 35, 36, 37, 38, 39, 40, 143, 154, 158, 159, 415
binding glutathione: 121, 195, 196

6hvjA Human pfkfb3 in complex with a n-aryl 6-aminoquinoxaline inhibitor 3 (see paper)
31% identity, 74% coverage: 12:172/217 of query aligns to 232:383/430 of 6hvjA

query
sites
6hvjA

V

I

Y

Y

L

L

W

C

R
|
R

H
|
H

P

G

E

E

V

N

R

E

G

H

V
x
N

A

L

D

Q

G

G

R

R

V

I

Y
x
G

G

G

N

-

M

-

D

D

V

S

G

G

L

L

T

S

P

S

R

R

G

G

Q

K

R

K

Q

F

V

A

A

S

L

A

V

L

A

S

E

K

R

F

M

V

A

E

E

E

T

Q

R

N

L

L

D

K

A

D

-

L

-

R

I

V

Y

W

S

T

S

S

D

Q

L

L

S

K

R
x
S

S

T

L

I

T

Q

T

T

A

A

E

E

A

A

V

L

G

-

R

-

A

-

Q

-

K

-

A

-

R

R

L

L

R

P

P

Y

V

E

A

Q

V

W

R

K

E

A

L

L

R

N

E
|
E

L

I

N

D

L

A

G

G

V

V

W

C

E

E

G

E

L

L

T

T

F
x
Y

K

E

E

E

I

I

M

R

E

D

K

T

Y

Y

P

P

D

E

A

E

L

Y

K

A

A

L

R
|
R

Y

E

E

Q

D

D

L
x
K

A

Y

N

Y

F

Y

K

R

I

Y

D

P

G

T

G

G

E

E

S

S

L
x
Y

E

Q

E

D

M

L

S

V

R

Q

R

R

V

L

M

E

P

P

A

V

F

I

E

M

Q

E

I

L

V

-

A

-

D

-

H

E

R

R

G

Q

G

E

E

N

V

V

C

L

V

V

V

I

S

C

H
|
H

S
x
Q

G

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N

L

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|
R

I

C

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L

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A

R

Y

M

F

L

L

active site: R236 (= R16), H237 (= H17), N243 (≠ V23), S286 (≠ R66), E306 (= E92), H371 (= H160)
binding 6-O-phosphono-beta-D-fructofuranose: G249 (≠ Y29), E306 (= E92), Y317 (≠ F103), R331 (= R117), K335 (≠ L121), Y346 (≠ L132), Q372 (≠ S161), R376 (= R165)

Sites not aligning to the query:

binding 8-(3-methyl-1-benzofuran-5-yl)-~{N}-(4-methylsulfonylpyridin-3-yl)quinoxalin-6-amine: 29, 33, 34, 136, 138, 143, 147, 151, 198, 225, 407
binding phosphate ion: 28, 29, 30, 31, 32, 152

3qpwA Pfkfb3 in complex with aluminum tetrafluoride (see paper)
31% identity, 74% coverage: 12:172/217 of query aligns to 240:391/431 of 3qpwA

query
sites
3qpwA

V

I

Y

Y

L

L

W

C

R
|
R

H
|
H

P

G

E

E

V

N

R

E

G

H

V
x
N

A

L

D

Q

G

G

R

R

V

I

Y

G

G

G

N

-

M

-

D

D

V

S

G

G

L

L

T

S

P

S

R

R

G

G

Q

K

R

K

Q

F

V

A

A

S

L

A

V

L

A

S

E

K

R

F

M

V

A

E

E

E

T

Q

R

N

L

L

D

K

A

D

-

L

-

R

I

V

Y

W

S

T

S

S

D

Q

L

L

S

K

R
x
S

S

T

L

I

T

Q

T

T

A

A

E

E

A

A

V

L

G

-

R

-

A

-

Q

-

K

-

A

-

R

R

L

L

R

P

P

Y

V

E

A

Q

V

W

R

K

E

A

L

L

R

N

E
|
E

L

I

N

D

L

A

G

G

V

V

W

C

E

E

G

E

L

L

T

T

F

Y

K

E

E

E

I

I

M

R

E

D

K

T

Y

Y

P

P

D

E

A

E

L

Y

K

A

A

L

R

R

Y

E

E

Q

D

D

L

K

A

Y

N

Y

F

Y

K

R

I

Y

D

P

G

T

G

G

E

E

S

S

L

Y

E

Q

E

D

M

L

S

V

R

Q

R

R

V

L

M

E

P

P

A

V

F

I

E

M

Q

E

I

L

V

-

A

-

D

-

H

E

R

R

G

Q

G

E

E

N

V

V

C

L

V

V

V

I

S

C

H
|
H

S
x
Q

G

A

V

V

N

L

R

R

I

C

L

L

T

A

R

Y

M

F

L

L

active site: R244 (= R16), H245 (= H17), N251 (≠ V23), S294 (≠ R66), E314 (= E92), H379 (= H160)
binding tetrafluoroaluminate ion: R244 (= R16), H245 (= H17), H379 (= H160), Q380 (≠ S161)

Sites not aligning to the query:

binding adenosine-5'-diphosphate: 36, 37, 38, 39, 40, 41, 144, 155, 158, 159, 160, 235, 416
binding phosphoenolpyruvate: 63, 66, 79, 90, 118, 185

6ibyA Human pfkfb3 in complex with a n-aryl 6-aminoquinoxaline inhibitor 6 (see paper)
31% identity, 74% coverage: 12:172/217 of query aligns to 230:381/428 of 6ibyA

query
sites
6ibyA

V

I

Y

Y

L

L

W

C

R

R

H

H

P

G

E

E

V

N

R

E

G

H

V

N

A

L

D

Q

G

G

R

R

V

I

Y
x
G

G

G

N

-

M

-

D

D

V

S

G

G

L

L

T

S

P

S

R

R

G

G

Q

K

R

K

Q

F

V

A

A

S

L

A

V

L

A

S

E

K

R

F

M

V

A

E

E

E

T

Q

R

N

L

L

D

K

A

D

-

L

-

R

I

V

Y

W

S

T

S

S

D

Q

L

L

S

K

R

S

S

T

L

I

T

Q

T

T

A

A

E

E

A

A

V

L

G

-

R

-

A

-

Q

-

K

-

A

-

R

R

L

L

R

P

P

Y

V

E

A

Q

V

W

R

K

E

A

L

L

R

N

E
|
E

L

I

N

D

L

A

G

G

V

V

W

C

E

E

G

E

L

L

T

T

F
x
Y

K

E

E

E

I

I

M

R

E

D

K

T

Y

Y

P

P

D

E

A

E

L

Y

K

A

A

L

R
|
R

Y

E

E

Q

D

D

L
x
K

A

Y

N

Y

F

Y

K

R

I

Y

D

P

G

T

G

G

E

E

S

S

L
x
Y

E

Q

E

D

M

L

S

V

R

Q

R

R

V

L

M

E

P

P

A

V

F

I

E

M

Q

E

I

L

V

-

A

-

D

-

H

E

R

R

G

Q

G

E

E

N

V

V

C

L

V

V

V

I

S

C

H

H

S
x
Q

G

A

V

V

N

L

R
|
R

I

C

L

L

T

A

R

Y

M

F

L

L

binding 6-O-phosphono-beta-D-fructofuranose: G247 (≠ Y29), E304 (= E92), Y315 (≠ F103), R329 (= R117), K333 (≠ L121), Y344 (≠ L132), Q370 (≠ S161), R374 (= R165)

Sites not aligning to the query:

binding 3-[[8-(1-methylindol-6-yl)quinoxalin-6-yl]amino]-~{N}-[(3~{S})-1-methylpyrrolidin-3-yl]pyridine-4-carboxamide: 27, 31, 32, 134, 136, 145, 148, 196, 199, 200, 223
binding pyrophosphate 2-: 25, 26, 27, 28, 29, 30, 31, 150, 406

5ajvB Human pfkfb3 in complex with an indole inhibitor 1 (see paper)
31% identity, 74% coverage: 12:172/217 of query aligns to 238:389/435 of 5ajvB

query
sites
5ajvB

V

I

Y

Y

L

L

W

C

R
|
R

H
|
H

P

G

E

E

V

N

R

E

G

H

V

N

A

L

D

Q

G

G

R

R

V

I

Y

G

G

G

N

-

M

-

D

D

V

S

G

G

L

L

T

S

P

S

R

R

G

G

Q

K

R

K

Q

F

V

A

A

S

L

A

V

L

A

S

E

K

R

F

M

V

A

E

E

E

T

Q

R

N

L

L

D

K

A

D

-

L

-

R

I

V

Y

W

S

T

S

S

D

Q

L

L

S

K

R

S

S

T

L

I

T

Q

T

T

A

A

E

E

A

A

V

L

G

-

R

-

A

-

Q

-

K

-

A

-

R

R

L

L

R

P

P

Y

V

E

A

Q

V

W

R

K

E

A

L

L

R

N

E
|
E

L

I

N

D

L

A

G

G

V

V

W

C

E

E

G

E

L

L

T

T

F
x
Y

K

E

E

E

I

I

M

R

E

D

K

T

Y

Y

P

P

D

E

A

E

L

Y

K

A

A

L

R
|
R

Y

E

E

Q

D

D

L
x
K

A

Y

N

Y

F

Y

K

R

I

Y

D

P

G

T

G

G

E

E

S

S

L
x
Y

E

Q

E

D

M

L

S

V

R

Q

R

R

V

L

M

E

P

P

A

V

F

I

E

M

Q

E

I

L

V

-

A

-

D

-

H

E

R

R

G

Q

G

E

E

N

V

V

C

L

V

V

V

I

S

C

H
|
H

S
x
Q

G

A

V

V

N

L

R
|
R

I

C

L

L

T

A

R

Y

M

F

L

L

binding 2,6-di-O-phosphono-beta-D-fructofuranose: R242 (= R16), H243 (= H17), E312 (= E92), Y323 (≠ F103), R337 (= R117), K341 (≠ L121), Y352 (≠ L132), H377 (= H160), Q378 (≠ S161), R382 (= R165)

Sites not aligning to the query:

binding (2S)-2-amino-N-[4-[(2-amino-3-cyano-1H-indol-5-yl)oxy]phenyl]-3-hydroxy-propanamide: 35, 39, 40, 204, 207, 208, 228, 229, 231

Query Sequence

>WP_013257191.1 NCBI__GCF_000143965.1:WP_013257191.1
MQRRQQRKHTRVYLWRHPEVRGVADGRVYGNMDVGLTPRGQRQVALVAERMAETRLDAIY
SSDLSRSLTTAEAVGRAQKARLRPVAVRELRELNLGVWEGLTFKEIMEKYPDALKARYED
LANFKIDGGESLEEMSRRVMPAFEQIVADHRGGEVCVVSHSGVNRILLTRMLGAPLDRIF
RIDQDFACLNVVDIFNDGTPLVRRINDLMEDPAWLEH

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory