Comparing WP_013258699.1 NCBI__GCF_000143965.1:WP_013258699.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
3pg9A Thermotoga maritima dah7p synthase in complex with inhibitor (see paper)
45% identity, 89% coverage: 33:336/343 of query aligns to 30:329/338 of 3pg9A
Sites not aligning to the query:
1rzmA Crystal structure of 3-deoxy-d-arabino-heptulosonate-7-phosphate synthase (dahps) from thermotoga maritima complexed with cd2+, pep and e4p (see paper)
45% identity, 89% coverage: 33:336/343 of query aligns to 30:329/338 of 1rzmA
4grsA Crystal structure of a chimeric dah7ps (see paper)
45% identity, 85% coverage: 33:322/343 of query aligns to 30:317/333 of 4grsA
Sites not aligning to the query:
4c1kA Crystal structure of pyrococcus furiosus 3-deoxy-d-arabino- heptulosonate 7-phosphate synthase (see paper)
47% identity, 67% coverage: 92:322/343 of query aligns to 18:246/262 of 4c1kA
1zcoB Crystal structure of pyrococcus furiosus 3-deoxy-d-arabino- heptulosonate 7-phosphate synthase (see paper)
46% identity, 67% coverage: 92:322/343 of query aligns to 18:246/262 of 1zcoB
1zcoA Crystal structure of pyrococcus furiosus 3-deoxy-d-arabino- heptulosonate 7-phosphate synthase (see paper)
46% identity, 67% coverage: 92:322/343 of query aligns to 18:246/262 of 1zcoA
5j6fA Crystal structure of dah7ps-cm complex from geobacillus sp. With prephenate (see paper)
43% identity, 75% coverage: 75:331/343 of query aligns to 94:349/352 of 5j6fA
Sites not aligning to the query:
3tfcA 1.95 angstrom crystal structure of a bifunctional 3-deoxy-7- phosphoheptulonate synthase/chorismate mutase (aroa) from listeria monocytogenes egd-e in complex with phosphoenolpyruvate (see paper)
44% identity, 67% coverage: 91:319/343 of query aligns to 98:325/343 of 3tfcA
3nvtA 1.95 angstrom crystal structure of a bifunctional 3-deoxy-7- phosphoheptulonate synthase/chorismate mutase (aroa) from listeria monocytogenes egd-e (see paper)
44% identity, 67% coverage: 91:319/343 of query aligns to 99:326/345 of 3nvtA
P39912 Protein AroA(G); EC 2.5.1.54; EC 5.4.99.5 from Bacillus subtilis (strain 168) (see paper)
43% identity, 75% coverage: 75:331/343 of query aligns to 96:355/358 of P39912
Sites not aligning to the query:
1vs1D Crystal structure of 3-deoxy-d-arabino-heptulosonate-7-phosphate synthase (dahp synthase) from aeropyrum pernix in complex with mn2+ and pep
51% identity, 69% coverage: 91:326/343 of query aligns to 26:261/271 of 1vs1D
3undB Substrate-bound crystal structure of 2-dehydro-3-deoxyphosphooctonate aldolase from burkholderia pseudomallei (see paper)
33% identity, 53% coverage: 137:319/343 of query aligns to 66:256/284 of 3undB
Sites not aligning to the query:
1pcwA Aquifex aeolicus kdo8ps in complex with cadmium and app, a bisubstrate inhibitor (see paper)
29% identity, 70% coverage: 100:340/343 of query aligns to 5:250/257 of 1pcwA
1x6uA Kdo8p synthase in it's binary complex with the product kdo8p (see paper)
28% identity, 73% coverage: 82:333/343 of query aligns to 2:255/272 of 1x6uA
1phwA Crystal structure of kdo8p synthase in its binary complex with substrate analog 1-deoxy-a5p (see paper)
28% identity, 73% coverage: 82:333/343 of query aligns to 2:255/272 of 1phwA
1phqA Crystal structure of kdo8p synthase in its binary complex with substrate analog e-fpep
28% identity, 73% coverage: 82:333/343 of query aligns to 2:255/272 of 1phqA
1gg0A Crystal structure analysis of kdop synthase at 3.0 a (see paper)
27% identity, 73% coverage: 82:333/343 of query aligns to 2:258/275 of 1gg0A
1pe1A Aquifex aeolicus kdo8ps in complex with cadmium and 2-pga (see paper)
29% identity, 70% coverage: 100:340/343 of query aligns to 6:251/258 of 1pe1A
1pckA Aquifex aeolicus kdo8ps in complex with z-methyl-pep (see paper)
28% identity, 70% coverage: 100:340/343 of query aligns to 5:251/258 of 1pckA
3e12A Cu2+ substituted aquifex aeolicus kdo8ps in complex with kdo8p (see paper)
28% identity, 70% coverage: 100:340/343 of query aligns to 5:251/258 of 3e12A
>WP_013258699.1 NCBI__GCF_000143965.1:WP_013258699.1
MIIQMEAKAGEKQLERLVERLGNDGFPPEMLDISRGDTFILVGLKGDTRAIDEGAYRALD
YVLDVIRISDPCKELTRDFHPRPSIIRLGSGLRIGKDLAVIAGPCAIESRDQLMKTAKLV
VDAGANILRGGAFKPRTIHRSFQGLREDGLKLLAEAREKFGIPVITEIMDARDIHLFVEY
DIDIWQVGARNCLNYTLLDALAEMKNPKPVVLKRGDHVSISEFLGAALRLYDGNTKVILC
ERGDKTVDPVYRNVLNLNNVAWLKKRYHLPVLVDPSHGTGVRQIVPDMALAGIAAGADGL
MVEVHHKPEEALCDGAQSLSADFKKLTPLVRQVFELRRQAKML
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory