SitesBLAST
Comparing WP_013259630.1 NCBI__GCF_000143965.1:WP_013259630.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
8a6tB Cryo-em structure of the electron bifurcating fe-fe hydrogenase hydabc complex from thermoanaerobacter kivui in the reduced state (see paper)
54% identity, 96% coverage: 14:626/638 of query aligns to 3:627/630 of 8a6tB
- binding fe2/s2 (inorganic) cluster: C31 (= C42), G33 (= G44), C36 (= C47), C82 (= C81), F85 (= F84), C86 (= C85)
- binding flavin mononucleotide: G201 (= G201), N227 (= N227), E230 (= E230), N355 (= N355), G535 (= G534), L536 (= L535)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: S320 (= S320), R337 (≠ K337), R340 (≠ H340), T341 (= T341), N342 (≠ V342), S433 (= S432)
- binding iron/sulfur cluster: S487 (= S486), C488 (= C487), G489 (= G488), C491 (= C490), C494 (= C493), C534 (= C533), L536 (= L535), G537 (= G536), Y575 (= Y574), I577 (= I576), C582 (= C581), I583 (≠ T582), C585 (= C584), C588 (= C587), C592 (= C591), A596 (= A595), I597 (= I596), I607 (= I606), C612 (= C611), C618 (= C617), C622 (= C621), K624 (≠ F623), A626 (= A625), I627 (≠ V626)
- binding zinc ion: C471 (= C470), H558 (= H557), C564 (= C563)
7q4vB Electron bifurcating hydrogenase - hydabc from a. Woodii (see paper)
57% identity, 93% coverage: 36:626/638 of query aligns to 5:596/599 of 7q4vB
- binding fe2/s2 (inorganic) cluster: C11 (= C42), C16 (= C47), C48 (= C81), F49 (≠ H82), L51 (≠ F84), C52 (= C85)
- binding flavin mononucleotide: G166 (= G199), G168 (= G201), N196 (= N227), D198 (= D229), F284 (= F315), G287 (= G318), E288 (= E319), E289 (≠ S320), N324 (= N355)
- binding iron/sulfur cluster: C457 (= C487), G458 (= G488), K459 (≠ Q489), C460 (= C490), C463 (= C493), C503 (= C533), G506 (= G536), F544 (≠ Y574), C551 (= C581), K552 (≠ T582), G553 (= G583), C554 (= C584), G555 (≠ H585), I556 (≠ A586), C557 (= C587), C561 (= C591), P562 (= P592), Y574 (≠ H604), C581 (= C611), K583 (= K613), C584 (= C614), G585 (≠ S615), A586 (≠ I616), C587 (= C617), C591 (= C621), F593 (= F623), S595 (≠ A625)
- binding zinc ion: C440 (= C470), H527 (= H557), C533 (= C563)
8oh5B Cryo-em structure of the electron bifurcating transhydrogenase stnabc complex from sporomusa ovata (state 2) (see paper)
56% identity, 92% coverage: 44:629/638 of query aligns to 8:584/584 of 8oh5B
- binding fe2/s2 (inorganic) cluster: C10 (≠ G46), C41 (= C81), C45 (= C85)
- binding flavin mononucleotide: R154 (= R200), K164 (= K210), N181 (= N227), F269 (= F315), E273 (= E319), E274 (≠ S320), I307 (≠ L353), N308 (= N354), N309 (= N355), G489 (= G534), L490 (= L535)
- binding nicotinamide-adenine-dinucleotide: G155 (= G201), G156 (= G202), F159 (= F205), F163 (≠ L209), E273 (= E319), E274 (≠ S320), K291 (= K337), F294 (≠ H340), G413 (= G458)
- binding iron/sulfur cluster: P288 (= P334), C442 (= C487), G443 (= G488), C445 (= C490), C448 (= C493), C488 (= C533), L490 (= L535), G491 (= G536), I531 (= I576), C536 (= C581), T540 (≠ H585), C542 (= C587), C546 (= C591), P547 (= P592), V548 (≠ Q593), H559 (= H604), C566 (= C611), T567 (≠ I612), K568 (= K613), C569 (= C614), C572 (= C617)
- binding zinc ion: C425 (= C470), H512 (= H557), C518 (= C563), C523 (= C568)
7p8nB Tmhydabc- t. Maritima hydrogenase with bridge closed (see paper)
50% identity, 95% coverage: 22:626/638 of query aligns to 13:612/613 of 7p8nB
- binding fe2/s2 (inorganic) cluster: C31 (= C42), G33 (= G44), T34 (≠ S45), C36 (= C47), C67 (= C81), C68 (≠ H82), G69 (= G83), R70 (≠ F84), C71 (= C85)
- binding flavin mononucleotide: G185 (= G199), R186 (= R200), G187 (= G201), N213 (= N227), D215 (= D229), E216 (= E230), G217 (= G231), F301 (= F315), G304 (= G318), E305 (= E319), E306 (≠ S320), N340 (= N354), N341 (= N355), G521 (= G534), L522 (= L535)
- binding iron/sulfur cluster: P320 (= P334), S473 (= S486), C474 (= C487), G475 (= G488), K476 (≠ Q489), C477 (= C490), C480 (= C493), L519 (= L532), C520 (= C533), L522 (= L535), G523 (= G536), Y560 (= Y574), C567 (= C581), C570 (= C584), G571 (≠ H585), C573 (= C587), C577 (= C591), Y590 (≠ H604), I592 (= I606), C597 (= C611), K599 (= K613), C600 (= C614), G601 (≠ S615), C603 (= C617), C607 (= C621)
- binding zinc ion: C457 (= C470), H544 (= H557), C549 (= C563), C554 (= C568)
7q4vF Electron bifurcating hydrogenase - hydabc from a. Woodii (see paper)
63% identity, 73% coverage: 163:626/638 of query aligns to 1:467/470 of 7q4vF
- binding flavin mononucleotide: G37 (= G199), G39 (= G201), N67 (= N227), G158 (= G318), E159 (= E319), E160 (≠ S320), G375 (= G534)
- binding nicotinamide-adenine-dinucleotide: G40 (= G202), F43 (= F205), K48 (= K210), R177 (≠ K337), F180 (≠ H340), M297 (= M456)
- binding iron/sulfur cluster: S327 (= S486), C328 (= C487), G329 (= G488), K330 (≠ Q489), C331 (= C490), C334 (= C493), L373 (= L532), C374 (= C533), F415 (≠ Y574), I417 (= I576), C422 (= C581), G424 (= G583), C425 (= C584), G426 (≠ H585), I427 (≠ A586), C428 (= C587), C432 (= C591), P433 (= P592), I437 (= I596), Y445 (≠ H604), C452 (= C611), K454 (= K613), C455 (= C614), G456 (≠ S615), A457 (≠ I616), C458 (= C617), C462 (= C621), P463 (≠ K622), I467 (≠ V626)
- binding zinc ion: C311 (= C470), H398 (= H557), C404 (= C563), C409 (= C568)
8a5eB Cryo-em structure of the electron bifurcating fe-fe hydrogenase hydabc complex from acetobacterium woodii in the reduced state (see paper)
64% identity, 69% coverage: 187:626/638 of query aligns to 2:444/447 of 8a5eB
- binding flavin mononucleotide: G14 (= G199), G16 (= G201), N44 (= N227), G135 (= G318), E137 (≠ S320), N171 (= N354), N172 (= N355), G352 (= G534)
- binding 1,4-dihydronicotinamide adenine dinucleotide: G16 (= G201), G17 (= G202), F20 (= F205), K25 (= K210), F28 (≠ S213), D49 (= D232), R154 (≠ K337), F157 (≠ H340), S250 (= S432)
- binding iron/sulfur cluster: P151 (= P334), C305 (= C487), G306 (= G488), K307 (≠ Q489), C308 (= C490), C311 (= C493), C351 (= C533), G354 (= G536), F392 (≠ Y574), C399 (= C581), G401 (= G583), C402 (= C584), G403 (≠ H585), C405 (= C587), C409 (= C591), P410 (= P592), I414 (= I596), C429 (= C611), K431 (= K613), C432 (= C614), G433 (≠ S615), C435 (= C617), C439 (= C621), P440 (≠ K622), I444 (≠ V626)
- binding zinc ion: C288 (= C470), H375 (= H557), C381 (= C563), C386 (= C568)
7t30B Structure of electron bifurcating ni-fe hydrogenase complex hydabcsl in fmn/NAD(h) bound state (see paper)
63% identity, 66% coverage: 148:568/638 of query aligns to 3:424/425 of 7t30B
- binding fe2/s2 (inorganic) cluster: C326 (= C470), C364 (= C508), H413 (= H557), C419 (= C563), A421 (= A565), C424 (= C568)
- binding flavin mononucleotide: G54 (= G199), G56 (= G201), K65 (= K210), N82 (= N227), D84 (= D229), E85 (= E230), G173 (= G318), E175 (≠ S320), N210 (= N355), G390 (= G534), L391 (= L535)
- binding nicotinamide-adenine-dinucleotide: G56 (= G201), G57 (= G202), A58 (≠ G203), F60 (= F205), K65 (= K210), F68 (≠ S213), E85 (= E230), E175 (≠ S320), R192 (≠ K337), F195 (≠ H340), I312 (≠ M456), M313 (= M457), S315 (= S459)
- binding iron/sulfur cluster: S342 (= S486), C343 (= C487), G344 (= G488), C346 (= C490), C349 (= C493), S387 (= S531), C389 (= C533), L391 (= L535), G392 (= G536)
7t2rB Structure of electron bifurcating ni-fe hydrogenase complex hydabcsl in fmn-free apo state (see paper)
63% identity, 66% coverage: 148:568/638 of query aligns to 3:424/425 of 7t2rB
- binding fe2/s2 (inorganic) cluster: C326 (= C470), D329 (= D473), C364 (= C508), H413 (= H557), C419 (= C563), A421 (= A565), C424 (= C568)
- binding iron/sulfur cluster: P189 (= P334), C343 (= C487), G344 (= G488), C346 (= C490), C349 (= C493), C389 (= C533), G392 (= G536)
Q56222 NADH-quinone oxidoreductase subunit 1; NADH dehydrogenase I chain 1; NDH-1 subunit 1; EC 7.1.1.- from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) (see paper)
44% identity, 65% coverage: 149:561/638 of query aligns to 14:428/438 of Q56222
- K75 (= K210) binding FMN
- NADES 92:96 (≠ NADEG 227:231) binding FMN
- YICGEE 180:185 (≠ FVCGES 315:320) binding FMN
- INN 218:220 (≠ LNN 353:355) binding FMN
- C353 (= C487) binding [4Fe-4S] cluster
- C356 (= C490) binding [4Fe-4S] cluster
- C359 (= C493) binding [4Fe-4S] cluster
- C400 (= C533) binding [4Fe-4S] cluster
4hea1 Crystal structure of the entire respiratory complex i from thermus thermophilus (see paper)
44% identity, 65% coverage: 149:561/638 of query aligns to 13:427/437 of 4hea1
- binding flavin mononucleotide: G63 (= G199), K74 (= K210), N91 (= N227), D93 (= D229), Y179 (≠ F315), G182 (= G318), E183 (= E319), N218 (= N354), N219 (= N355), L401 (= L535)
- binding iron/sulfur cluster: I180 (≠ V316), P198 (= P334), S351 (= S486), C352 (= C487), G353 (= G488), K354 (≠ Q489), C355 (= C490), C358 (= C493), F398 (≠ L532), C399 (= C533), L401 (= L535)
2ybb1 Fitted model for bovine mitochondrial supercomplex i1iii2iv1 by single particle cryo-em (emd-1876) (see paper)
44% identity, 65% coverage: 149:561/638 of query aligns to 13:427/437 of 2ybb1
- binding flavin mononucleotide: G63 (= G199), G65 (= G201), N91 (= N227), D93 (= D229), G182 (= G318), E183 (= E319), E184 (≠ S320), N218 (= N354), N219 (= N355), T222 (= T358), P400 (≠ G534)
- binding 1,4-dihydronicotinamide adenine dinucleotide: G65 (= G201), G66 (= G202), F69 (= F205), K74 (= K210), F77 (≠ S213), E96 (≠ D232), Y179 (≠ F315), E184 (≠ S320), K201 (= K337), F204 (≠ H340), T324 (≠ S459)
- binding iron/sulfur cluster: S351 (= S486), C352 (= C487), K354 (≠ Q489), C355 (= C490), C358 (= C493), F398 (≠ L532), C399 (= C533), L401 (= L535), A402 (≠ G536)
6vw7D Formate dehydrogenase fdsabg subcomplex fdsbg from c. Necator - nadh bound (see paper)
46% identity, 65% coverage: 141:554/638 of query aligns to 97:510/514 of 6vw7D
- binding flavin mononucleotide: G154 (= G199), G156 (= G201), K165 (= K210), N182 (= N227), E185 (= E230), G273 (= G318), E274 (= E319), E275 (≠ S320), N309 (= N354), N310 (= N355), S313 (≠ T358), A490 (≠ G534), M491 (≠ L535)
- binding 1,4-dihydronicotinamide adenine dinucleotide: A158 (≠ G203), F160 (= F205), K165 (= K210), T168 (≠ S213), E275 (≠ S320), L295 (≠ H340)
- binding iron/sulfur cluster: V271 (= V316), V289 (≠ P334), S442 (= S486), C443 (= C487), G444 (= G488), K445 (≠ Q489), C446 (= C490), C449 (= C493), L488 (= L532), C489 (= C533), M491 (≠ L535), G492 (= G536)
6tg9B Cryo-em structure of nadh reduced form of NAD+-dependent formate dehydrogenase from rhodobacter capsulatus (see paper)
45% identity, 65% coverage: 139:554/638 of query aligns to 87:492/493 of 6tg9B
- binding flavin mononucleotide: G146 (= G199), R147 (= R200), G148 (= G201), N174 (= N227), D176 (= D229), E177 (= E230), Y254 (≠ F315), G257 (= G318), E258 (= E319), N293 (= N354), N294 (= N355), S297 (≠ T358)
- binding 1,4-dihydronicotinamide adenine dinucleotide: F152 (= F205), K157 (= K210), E258 (= E319), E259 (≠ S320), L279 (≠ H340), K466 (= K528), L470 (= L532)
- binding iron/sulfur cluster: S426 (= S486), C427 (= C487), G428 (= G488), T429 (≠ Q489), C430 (= C490), C433 (= C493), L470 (= L532), C471 (= C533), G474 (= G536)
6saqB Wild-type nuoef from aquifex aeolicus bound to nadh-oh (see paper)
44% identity, 62% coverage: 164:557/638 of query aligns to 30:416/419 of 6saqB
- binding flavin mononucleotide: G64 (= G199), G66 (= G201), K75 (= K210), N91 (= N227), D93 (= D229), E94 (= E230), Y179 (≠ F315), G182 (= G318), E183 (= E319), N218 (= N354), N219 (= N355), T222 (= T358)
- binding [[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{S},4~{R},5~{R})-5-[[(1~{E},3~{Z})-5-azanyl-4-oxidanyl-5-oxidanylidene-penta-1,3-dienyl]-methanoyl-amino]-3,4-bis(oxidanyl)oxolan-2-yl]methyl hydrogen phosphate: G66 (= G201), G67 (= G202), A68 (≠ G203), F70 (= F205), K75 (= K210), E94 (= E230), E96 (≠ D232), T99 (≠ A235), E184 (≠ S320), Y204 (≠ H340), T318 (≠ S459)
- binding iron/sulfur cluster: P198 (= P334), T345 (≠ S486), C346 (= C487), G347 (= G488), Q348 (= Q489), C349 (= C490), C352 (= C493), I391 (≠ L532), C392 (= C533), G395 (= G536)
8qgwB Crystal structure of oxidized respiratory complex i subunits nuoef from aquifex aeolicus bound to oxidized 3-acetylpyridine adenine dinucleotide (see paper)
44% identity, 62% coverage: 164:557/638 of query aligns to 29:415/418 of 8qgwB
- binding 3-acetylpyridine adenine dinucleotide: G66 (= G202), A67 (≠ G203), F69 (= F205), K74 (= K210), E183 (≠ S320), Y203 (≠ H340)
- binding flavin mononucleotide: G63 (= G199), G65 (= G201), K74 (= K210), N90 (= N227), E93 (= E230), Y178 (≠ F315), G181 (= G318), E182 (= E319), E183 (≠ S320), V216 (≠ L353), N217 (= N354), N218 (= N355), T221 (= T358)
- binding iron/sulfur cluster: P197 (= P334), T344 (≠ S486), C345 (= C487), G346 (= G488), Q347 (= Q489), C348 (= C490), C351 (= C493), I390 (≠ L532), C391 (= C533), L393 (= L535), G394 (= G536)
6q9cB Crystal structure of aquifex aeolicus nadh-quinone oxidoreductase subunits nuoe and nuof bound to nadh under anaerobic conditions (see paper)
44% identity, 62% coverage: 164:557/638 of query aligns to 30:416/418 of 6q9cB
- binding flavin mononucleotide: G64 (= G199), G66 (= G201), K75 (= K210), N91 (= N227), D93 (= D229), E94 (= E230), G182 (= G318), E183 (= E319), E184 (≠ S320), V217 (≠ L353), N218 (= N354), N219 (= N355), T222 (= T358), G393 (= G534)
- binding 1,4-dihydronicotinamide adenine dinucleotide: G66 (= G201), G67 (= G202), A68 (≠ G203), F70 (= F205), K75 (= K210), E94 (= E230), E96 (≠ D232), Y179 (≠ F315), E184 (≠ S320), Y204 (≠ H340)
- binding iron/sulfur cluster: P198 (= P334), T345 (≠ S486), C346 (= C487), G347 (= G488), Q348 (= Q489), C349 (= C490), C352 (= C493), I391 (≠ L532), C392 (= C533), L394 (= L535), G395 (= G536)
6hl3B Wild-type nuoef from aquifex aeolicus - oxidized form bound to NAD+ (see paper)
44% identity, 62% coverage: 164:557/638 of query aligns to 29:415/416 of 6hl3B
- binding flavin mononucleotide: G63 (= G199), G65 (= G201), K74 (= K210), N90 (= N227), D92 (= D229), E93 (= E230), G181 (= G318), E182 (= E319), E183 (≠ S320), V216 (≠ L353), N217 (= N354), N218 (= N355), T221 (= T358)
- binding nicotinamide-adenine-dinucleotide: G65 (= G201), G66 (= G202), A67 (≠ G203), F69 (= F205), K74 (= K210), E95 (≠ D232), Y178 (≠ F315), E183 (≠ S320), K200 (= K337), Y203 (≠ H340)
- binding iron/sulfur cluster: I179 (≠ V316), P197 (= P334), T344 (≠ S486), C345 (= C487), G346 (= G488), Q347 (= Q489), C348 (= C490), C351 (= C493), S389 (= S531), I390 (≠ L532), C391 (= C533), L393 (= L535), G394 (= G536)
6hl2B Wild-type nuoef from aquifex aeolicus - oxidized form (see paper)
44% identity, 62% coverage: 164:557/638 of query aligns to 29:415/416 of 6hl2B
- binding flavin mononucleotide: G63 (= G199), G65 (= G201), K74 (= K210), N90 (= N227), E93 (= E230), G181 (= G318), E182 (= E319), E183 (≠ S320), V216 (≠ L353), N217 (= N354), N218 (= N355), T221 (= T358)
- binding iron/sulfur cluster: P197 (= P334), T344 (≠ S486), C345 (= C487), G346 (= G488), Q347 (= Q489), C348 (= C490), C351 (= C493), S389 (= S531), I390 (≠ L532), C391 (= C533), G394 (= G536)
8qh7B Crystal structure of respiratory complex i subunits nuoef from aquifex aeolicus bound to reduced 3-acetylpyridine adenine dinucleotide (without reducing agent) (see paper)
44% identity, 62% coverage: 164:557/638 of query aligns to 29:415/417 of 8qh7B
- binding acetyl pyridine adenine dinucleotide, reduced: G65 (= G201), G66 (= G202), A67 (≠ G203), F69 (= F205), K74 (= K210), E93 (= E230), E95 (≠ D232), Y178 (≠ F315), E183 (≠ S320), Y203 (≠ H340)
- binding 1-deoxy-1-(7,8-dimethyl-2,4-dioxo-3,4-dihydro-2h-benzo[g]pteridin-1-id-10(5h)-yl)-5-o-phosphonato-d-ribitol: G63 (= G199), G65 (= G201), K74 (= K210), N90 (= N227), D92 (= D229), E93 (= E230), G181 (= G318), E182 (= E319), V216 (≠ L353), N217 (= N354), N218 (= N355), T221 (= T358)
- binding iron/sulfur cluster: P197 (= P334), T344 (≠ S486), C345 (= C487), G346 (= G488), Q347 (= Q489), C348 (= C490), C351 (= C493), S389 (= S531), I390 (≠ L532), C391 (= C533), L393 (= L535), G394 (= G536)
8qg1B Crystal structure of oxidized respiratory complex i subunits nuoef from aquifex aeolicus bound to adp-ribose (see paper)
44% identity, 62% coverage: 164:557/638 of query aligns to 29:415/417 of 8qg1B
- binding adenosine-5-diphosphoribose: G66 (= G202), A67 (≠ G203), F69 (= F205), K74 (= K210), E183 (≠ S320), Y203 (≠ H340)
- binding flavin mononucleotide: G63 (= G199), G65 (= G201), K74 (= K210), N90 (= N227), D92 (= D229), E93 (= E230), Y178 (≠ F315), G181 (= G318), E182 (= E319), V216 (≠ L353), N217 (= N354), N218 (= N355), T221 (= T358)
- binding iron/sulfur cluster: P197 (= P334), T344 (≠ S486), C345 (= C487), G346 (= G488), Q347 (= Q489), C348 (= C490), C351 (= C493), I390 (≠ L532), C391 (= C533), L393 (= L535), G394 (= G536)
Query Sequence
>WP_013259630.1 NCBI__GCF_000143965.1:WP_013259630.1
MNDSYKAESQRGFRLSSLEDFNKLRQRIEAQRDPAKGEIVVCHGSGCLAAGAAQVAEALE
SAIAAADLDVAVRPVVKITGCHGFCSCGPLVVIHPEGIFYQKVQPSDAEEIVQESLINGR
PVTRLLYADPGTKEKFVRVADIPFYNLQERVVLRNIGHIDPTDITDAIAAGGYQGLAKAL
GEMTPAEIIEEVKSSGLRGRGGGGFPTGLKWQSCAKAEGEPKYVICNADEGDPGAYMDRS
ILEGDPFSVLEGMTIAAYAVGARHGFVYVRNEYPLAVVRLVGAIKQAKQYGLLGENILGL
GFDFDIKISTGAGAFVCGESTALMRSLEGKVGRPRAKYIHTVEHGYRDKPSNLNNVETFA
NVPMIIKNGAQWFASMGTATSKGTKVFSLVGNVKNTGLVEVPMGASLRHIVYDVGGGTLK
KAFKAVQSGGPSGGCIPASMLDIPVDYEKLVETGAMMGSGGMIVMDQDTCMVDVARYFLE
FLQEESCGQCTPCREGIKRLLQILTDICQGRGREGDIELLQELSATVKELSLCGLGGSAP
NPVLSTIRYFRDEYESHIRDKFCPAGVCKELFQYEIDPEACTGCHACWRKCPQQAISGEK
KKPHVIDQAKCIKCSICYDACKFNAVVVKPNKKQEPRQ
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory