SitesBLAST
Comparing WP_013259992.1 NCBI__GCF_000143965.1:WP_013259992.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 12 hits to proteins with known functional sites (download)
5c4iE Structure of an oxalate oxidoreductase (see paper)
42% identity, 60% coverage: 29:93/109 of query aligns to 243:303/312 of 5c4iE
- binding iron/sulfur cluster: C258 (= C45), T259 (≠ I46), E260 (≠ K47), C261 (= C48), Y262 (≠ G49), C264 (= C51), C268 (= C55), C272 (≠ A59), C287 (= C77), K288 (= K78), G289 (= G79), C290 (= C80), G291 (= G81), C293 (= C83), C297 (= C87), P298 (= P88), S299 (≠ K89), L302 (≠ I92)
5exdH Crystal structure of oxalate oxidoreductase from moorella thermoacetica bound with carboxy-di-oxido-methyl-tpp (coom-tpp) intermediate (see paper)
42% identity, 60% coverage: 29:93/109 of query aligns to 222:282/291 of 5exdH
- binding iron/sulfur cluster: P230 (= P38), C237 (= C45), T238 (≠ I46), E239 (≠ K47), C240 (= C48), Y241 (≠ G49), C243 (= C51), C247 (= C55), P259 (≠ Y70), C266 (= C77), K267 (= K78), G268 (= G79), C269 (= C80), G270 (= G81), C272 (= C83), C276 (= C87), S278 (≠ K89), L281 (≠ I92)
7bkbK Formate dehydrogenase - heterodisulfide reductase - formylmethanofuran dehydrogenase complex from methanospirillum hungatei (hexameric, composite structure) (see paper)
44% identity, 49% coverage: 40:92/109 of query aligns to 168:226/386 of 7bkbK
- binding iron/sulfur cluster: C173 (= C45), T174 (≠ I46), K175 (= K47), C176 (= C48), C179 (= C51), C183 (= C55), I186 (≠ M58), C211 (= C77), D212 (≠ K78), C214 (= C80), N215 (≠ G81), C217 (= C83), C221 (= C87), P222 (= P88)
Sites not aligning to the query:
- binding iron/sulfur cluster: 36, 37, 39, 42, 46, 47, 51, 77, 78, 79, 80, 81, 83, 87, 92, 119, 124, 125, 127, 130, 134, 139, 241, 248, 249, 251, 254, 258, 259, 263, 265, 273, 280, 281, 284, 286, 287, 291, 322, 323, 324, 325, 326, 328, 332, 333
7ak5I Cryo-em structure of respiratory complex i in the deactive state from mus musculus at 3.2 a (see paper)
34% identity, 80% coverage: 6:92/109 of query aligns to 26:133/178 of 7ak5I
- binding iron/sulfur cluster: H67 (≠ W32), C79 (= C45), I80 (= I46), A81 (≠ K47), C82 (= C48), K83 (≠ G49), C85 (= C51), C89 (= C55), C118 (= C77), I119 (≠ K78), Y120 (≠ G79), C121 (= C80), G122 (= G81), C124 (= C83), C128 (= C87), I133 (= I92)
Sites not aligning to the query:
8ugh1I NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial (see paper)
34% identity, 79% coverage: 7:92/109 of query aligns to 25:131/176 of 8ugh1I
- binding n-acetylalanine: E44 (= E20), P45 (= P21)
- binding iron/sulfur cluster: H65 (≠ W32), C77 (= C45), I78 (= I46), A79 (≠ K47), C80 (= C48), K81 (≠ G49), L82 (= L50), C83 (= C51), C87 (= C55), P88 (= P56), I92 (≠ F60), Y109 (= Y70), C116 (= C77), I117 (≠ K78), Y118 (≠ G79), C119 (= C80), G120 (= G81), C122 (= C83), C126 (= C87), A130 (= A91), I131 (= I92)
Sites not aligning to the query:
5gupH structure of mammalian respiratory supercomplex I1III2IV1 (see paper)
34% identity, 79% coverage: 7:92/109 of query aligns to 25:131/176 of 5gupH
- binding (9r,11s)-9-({[(1s)-1-hydroxyhexadecyl]oxy}methyl)-2,2-dimethyl-5,7,10-trioxa-2lambda~5~-aza-6lambda~5~-phosphaoctacosane-6,6,11-triol: W27 (= W9), L30 (= L12)
- binding iron/sulfur cluster: H65 (≠ W32), C77 (= C45), I78 (= I46), A79 (≠ K47), C80 (= C48), K81 (≠ G49), C83 (= C51), C87 (= C55), C116 (= C77), I117 (≠ K78), Y118 (≠ G79), C119 (= C80), G120 (= G81), F121 (≠ I82), C122 (= C83), C126 (= C87), P127 (= P88), A130 (= A91), I131 (= I92)
- binding : R108 (≠ Y69)
Sites not aligning to the query:
7b0nI 3.7-angstrom structure of Yarrowia lipolytica complex I with an R121M mutation in NUCM. (see paper)
36% identity, 64% coverage: 23:92/109 of query aligns to 72:146/191 of 7b0nI
- binding iron/sulfur cluster: H80 (≠ W32), C92 (= C45), I93 (= I46), A94 (≠ K47), C95 (= C48), K96 (≠ G49), C98 (= C51), C102 (= C55), C131 (= C77), I132 (≠ K78), Y133 (≠ G79), C134 (= C80), G135 (= G81), C137 (= C83), C141 (= C87)
Sites not aligning to the query:
8ugp1I NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial (see paper)
38% identity, 63% coverage: 24:92/109 of query aligns to 12:81/126 of 8ugp1I
- binding iron/sulfur cluster: H19 (≠ W32), C30 (= C45), I31 (= I46), A32 (≠ K47), C33 (= C48), K34 (≠ G49), C36 (= C51), C40 (= C55), P41 (= P56), I45 (≠ F60), Y59 (= Y70), C66 (= C77), I67 (≠ K78), Y68 (≠ G79), C69 (= C80), G70 (= G81), C72 (= C83), C76 (= C87), V78 (≠ K89), I81 (= I92)
- binding : R23 (= R36), Y24 (≠ R37), E27 (≠ R42), E28 (= E43), R29 (≠ K44), C33 (= C48), K34 (≠ G49), T46 (≠ S61), A49 (vs. gap), E50 (vs. gap), P51 (= P62), S53 (≠ P64), R54 (≠ N65), R58 (≠ Y69), D60 (≠ N71), P77 (= P88)
Sites not aligning to the query:
7arcI Cryo-em structure of polytomella complex-i (peripheral arm) (see paper)
36% identity, 65% coverage: 22:92/109 of query aligns to 79:154/199 of 7arcI
- binding iron/sulfur cluster: H88 (≠ W32), C100 (= C45), I101 (= I46), S102 (≠ K47), C103 (= C48), K104 (≠ G49), C106 (= C51), C110 (= C55), P111 (= P56), I115 (≠ F60), Y132 (= Y70), C139 (= C77), I140 (≠ K78), Y141 (≠ G79), C142 (= C80), G143 (= G81), F144 (≠ I82), C145 (= C83), C149 (= C87), A153 (= A91), I154 (= I92)
- binding : R131 (≠ Y69)
Sites not aligning to the query:
8e73S8 qcr9 (see paper)
37% identity, 63% coverage: 24:92/109 of query aligns to 63:136/181 of 8e73S8
- binding iron/sulfur cluster: H70 (≠ W32), C82 (= C45), I83 (= I46), C85 (= C48), K86 (≠ G49), C88 (= C51), C92 (= C55), I97 (≠ F60), C121 (= C77), I122 (≠ K78), Y123 (≠ G79), C124 (= C80), G125 (= G81), F126 (≠ I82), C127 (= C83), C131 (= C87), P132 (= P88), A135 (= A91), I136 (= I92)
Sites not aligning to the query:
Q9VF27 NADH dehydrogenase (ubiquinone) 23 kDa subunit; EC 7.1.1.2 from Drosophila melanogaster (Fruit fly) (see paper)
38% identity, 63% coverage: 24:92/109 of query aligns to 99:172/217 of Q9VF27
Sites not aligning to the query:
- 199 G→D: Disrupts mitochondrial function and results in enlarged mitochondria. Neurons present vacuolar lesions leading to neurodegeneration in the central brain. Results in behavioral defects and shorten lifespan.
8b9zI Drosophila melanogaster complex i in the active state (dm1) (see paper)
33% identity, 75% coverage: 11:92/109 of query aligns to 45:141/186 of 8b9zI
- binding iron/sulfur cluster: H75 (≠ W32), C87 (= C45), I88 (= I46), A89 (≠ K47), C90 (= C48), K91 (≠ G49), C93 (= C51), C97 (= C55), P98 (= P56), Y119 (= Y70), C126 (= C77), I127 (≠ K78), Y128 (≠ G79), C129 (= C80), G130 (= G81), F131 (≠ I82), C132 (= C83), C136 (= C87), A140 (= A91), I141 (= I92)
Sites not aligning to the query:
Query Sequence
>WP_013259992.1 NCBI__GCF_000143965.1:WP_013259992.1
MADEGMVSWKSLALGCAMVEPGTSKRFNTGDWRSRRRPVTDREKCIKCGLCYILCPDMAF
SPDPNAEGYYNWDGYYCKGCGICVKECPKDAISWQEEKEEDKYGPACGA
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory