Comparing WP_013404426.1 NCBI__GCF_000166355.1:WP_013404426.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 8 hits to proteins with known functional sites (download)
P14407 Fumarate hydratase class I, anaerobic; D-tartrate dehydratase; Fumarase B; EC 4.2.1.2; EC 4.2.1.81 from Escherichia coli (strain K12) (see paper)
31% identity, 89% coverage: 32:278/278 of query aligns to 74:328/548 of P14407
Q4QAU9 Fumarate hydratase 1, mitochondrial; Fumarase 1; LmFH-1; EC 4.2.1.2 from Leishmania major (see paper)
30% identity, 83% coverage: 44:273/278 of query aligns to 93:333/549 of Q4QAU9
6msoA Crystal structure of mitochondrial fumarate hydratase from leishmania major in a complex with inhibitor thiomalate (see paper)
30% identity, 83% coverage: 44:273/278 of query aligns to 84:324/540 of 6msoA
Sites not aligning to the query:
E9AE57 Fumarate hydratase 2; Fumarase 2; LmFH-2; EC 4.2.1.2 from Leishmania major (see paper)
29% identity, 85% coverage: 44:278/278 of query aligns to 112:356/568 of E9AE57
Sites not aligning to the query:
6unzA Crystal structure of cytosolic fumarate hydratase from leishmania major (see paper)
29% identity, 85% coverage: 44:278/278 of query aligns to 92:336/539 of 6unzA
Sites not aligning to the query:
6uoiA Crystal structure of cytosolic fumarate hydratase from leishmania major in a complex with malonate (see paper)
29% identity, 85% coverage: 44:278/278 of query aligns to 87:331/535 of 6uoiA
Sites not aligning to the query:
6msnA Crystal structure of cytosolic fumarate hydratase from leishmania major in a complex with inhibitor thiomalate (see paper)
29% identity, 85% coverage: 44:278/278 of query aligns to 85:329/532 of 6msnA
Sites not aligning to the query:
6uqnB Crystal structure of r173a variant of cytosolic fumarate hydratase from leishmania major in a complex with fumarate and s-malate (see paper)
29% identity, 85% coverage: 44:278/278 of query aligns to 85:329/532 of 6uqnB
Sites not aligning to the query:
>WP_013404426.1 NCBI__GCF_000166355.1:WP_013404426.1
MRIVPAEIIEQKVYEAINQAVCILPDDVKDSLHKAYASEEGIAKYTLENLIKNIDLAQQK
MRPVCQDTGAAVFFVEIGEDVFIEGSLKDAINRAVSRAYTDFYLRKSMVKSPIERENTLD
NTPAIIHIDMAKGDKITIHFMPKGFGSENKSTICMLTPADGIEGIEKFVVETVKKAGSDP
CPPILVGVGIGGTFELAALLSKKALLRKVGQRHPRKYIAELEERLLEKINSLGIGPEGFG
GKTTALDVFIEEFPTHIAGLPVAVNICCHVARHVKIEI
Or try a new SitesBLAST search
SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory