SitesBLAST – Find functional sites

 

SitesBLAST

Comparing WP_013418715.1 NCBI__GCF_000166055.1:WP_013418715.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 4 hits to proteins with known functional sites (download)

6j2lA Crystal structure of bi-functional enzyme (see paper)
50% identity, 64% coverage: 33:121/139 of query aligns to 16:104/200 of 6j2lA

query
sites
6j2lA
G
 
G
L
 
L
I
 
M
G
 
P
A
 
V
I
 
I
V
 
V
T
 
Q
G
 
H
A
 
A
-
 
V
D
 
S
G
 
G
V
 
E
V
 
V
L
 
L
M
 
M
F
 
L
A
 
G
F
 
Y
M
 
M
N
 
N
A
 
P
E
 
E
A
 
A
L
 
L
R
 
D
L
 
K
T
 
T
L
 
I
E
 
E
T
 
S
G
 
G
E
 
K
A
 
V
H
 
T
F
 
F
Y
 
F
S
 
S
R
 
R
S
 
T
R
 
K
K
 
Q
S
 
R
L
 
L
W
 
W
K
 
I
K
 
K
G
 
G
E
 
E
T
 
T
S
 
S
G
 
G
N
 
N
V
 
F
L
 
L
R
 
N
V
 
V
R
 
V
E
 
S
L
 
I
L
 
A
T
 
P
D
|
D
C
 
C
D
|
D
Q
 
N
D
|
D
I
 
T
L
 
L
L
 
L
V
 
V
K
 
L
V
 
A
A
 
N
L
 
P
Q
 
I
G
 
G
E
 
-
A
 
P
A
 
T
C
|
C
H
 
H
T
 
K
G
 
G
R
 
T
H
 
S
S
 
S
C
|
C
F
 
F

Sites not aligning to the query:

7bgnA Crystal structure of mthisn2-amp complex, a bifunctional enzyme from the histidine biosynthetic pathway (see paper)
43% identity, 71% coverage: 28:125/139 of query aligns to 10:107/204 of 7bgnA

query
sites
7bgnA
R
 
K
F
 
W
D
 
D
E
 
N
H
 
K
G
 
G
L
 
L
I
 
A
G
 
V
A
 
A
I
 
I
V
 
A
T
 
Q
G
 
N
A
 
V
D
 
D
-
 
T
G
 
G
V
 
A
V
 
I
L
 
L
M
 
M
F
 
Q
A
 
G
F
 
F
M
 
A
N
 
N
A
 
R
E
 
E
A
 
A
L
 
V
R
 
A
L
 
T
T
 
T
L
 
I
E
 
S
T
 
S
G
 
R
E
 
K
A
 
A
H
 
T
F
 
F
Y
 
Y
S
 
S
R
 
R
S
 
S
R
 
R
K
 
S
S
 
S
L
 
L
W
|
W
K
 
T
K
|
K
G
|
G
E
 
E
T
|
T
S
|
S
G
 
N
N
 
N
V
 
F
L
 
I
R
 
N
V
 
V
R
 
H
E
 
D
L
 
V
L
 
F
T
 
L
D
|
D
C
 
C
D
|
D
Q
 
R
D
|
D
I
 
S
L
 
I
L
 
I
V
 
Y
K
 
L
V
 
G
A
 
K
L
 
P
Q
 
D
G
 
G
E
 
-
A
 
P
A
x
T
C
|
C
H
|
H
T
 
T
G
 
G
R
 
A
H
 
E
S
 
T
C
|
C
F
 
Y
Y
 
Y
R
 
T
R
 
P
V
 
V

Sites not aligning to the query:

7bgmA Crystal structure of mthisn2, a bifunctional enzyme from the histidine biosynthetic pathway (see paper)
43% identity, 71% coverage: 28:125/139 of query aligns to 12:109/213 of 7bgmA

query
sites
7bgmA
R
 
K
F
 
W
D
 
D
E
 
N
H
 
K
G
 
G
L
 
L
I
 
A
G
 
V
A
 
A
I
 
I
V
 
A
T
 
Q
G
 
N
A
 
V
D
 
D
-
 
T
G
 
G
V
 
A
V
 
I
L
 
L
M
 
M
F
 
Q
A
 
G
F
 
F
M
 
A
N
 
N
A
 
R
E
 
E
A
 
A
L
 
V
R
 
A
L
 
T
T
 
T
L
 
I
E
 
S
T
 
S
G
 
R
E
 
K
A
 
A
H
 
T
F
 
F
Y
 
Y
S
 
S
R
 
R
S
 
S
R
 
R
K
 
S
S
 
S
L
 
L
W
 
W
K
 
T
K
 
K
G
 
G
E
 
E
T
 
T
S
 
S
G
 
N
N
 
N
V
 
F
L
 
I
R
 
N
V
 
V
R
 
H
E
 
D
L
 
V
L
 
F
T
 
L
D
|
D
C
 
C
D
|
D
Q
 
R
D
|
D
I
 
S
L
 
I
L
 
I
V
 
Y
K
 
L
V
 
G
A
 
K
L
 
P
Q
 
D
G
 
G
E
 
-
A
 
P
A
 
T
C
|
C
H
 
H
T
 
T
G
 
G
R
 
A
H
 
E
S
 
T
C
|
C
F
 
Y
Y
 
Y
R
 
T
R
 
P
V
 
V

Sites not aligning to the query:

6j2lB Crystal structure of bi-functional enzyme (see paper)
49% identity, 58% coverage: 33:113/139 of query aligns to 15:96/185 of 6j2lB

query
sites
6j2lB
G
 
G
L
 
L
I
 
M
G
 
P
A
 
V
I
 
I
V
 
V
T
 
Q
G
 
H
A
 
A
-
 
V
D
 
S
G
 
G
V
 
E
V
 
V
L
 
L
M
 
M
F
 
L
A
 
G
F
 
Y
M
 
M
N
 
N
A
 
P
E
 
E
A
 
A
L
 
L
R
 
D
L
 
K
T
 
T
L
 
I
E
 
E
T
 
S
G
 
G
E
 
K
A
 
V
H
 
T
F
 
F
Y
 
F
S
 
S
R
 
R
S
 
T
R
 
K
K
 
Q
S
 
R
L
 
L
W
 
W
K
 
I
K
 
K
G
 
G
E
 
E
T
 
T
S
 
S
G
 
G
N
 
N
V
 
F
L
 
L
R
 
N
V
 
V
R
 
V
E
 
S
L
 
I
L
 
A
T
 
P
D
|
D
C
 
C
D
|
D
Q
 
N
D
|
D
I
 
T
L
 
L
L
 
L
V
 
V
K
 
L
V
 
A
A
 
N
L
 
P
Q
 
I
G
 
G
E
 
P
A
 
S
A
 
S
C
 
C

Sites not aligning to the query:

Query Sequence

>WP_013418715.1 NCBI__GCF_000166055.1:WP_013418715.1
MSAHSKLSFAKPSTSKAELEEGTAFTPRFDEHGLIGAIVTGADGVVLMFAFMNAEALRLT
LETGEAHFYSRSRKSLWKKGETSGNVLRVRELLTDCDQDILLVKVALQGEAACHTGRHSC
FYRRVDAGADGVALEFVTK

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory