SitesBLAST – Find functional sites

 

SitesBLAST

Comparing WP_013420262.1 NCBI__GCF_000166055.1:WP_013420262.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 3 hits to proteins with known functional sites (download)

7bgmA Crystal structure of mthisn2, a bifunctional enzyme from the histidine biosynthetic pathway (see paper)
39% identity, 79% coverage: 5:92/111 of query aligns to 127:212/213 of 7bgmA

query
sites
7bgmA
T
 
S
L
 
L
A
 
Y
R
 
A
L
 
L
A
 
E
A
 
S
T
 
T
I
 
I
K
 
S
A
 
Q
R
 
R
R
 
K
A
 
A
S
 
E
T
 
V
A
 
V
S
 
S
A
 
-
S
 
-
Y
 
W
T
 
T
K
 
K
S
 
R
L
 
L
L
 
L
E
 
L
K
 
N
G
 
D
A
 
K
A
 
L
A
 
L
C
 
C
A
 
S
K
 
K
K
 
-
L
 
I
G
 
R
E
 
E
E
|
E
A
 
A
V
 
N
E
 
E
T
 
-
V
 
L
I
 
C
A
 
E
G
 
T
V
 
L
A
 
E
E
 
N
S
 
N
D
 
E
D
 
D
K
 
K
L
 
S
R
 
R
-
 
T
-
 
A
A
 
S
E
|
E
A
 
M
A
 
A
D
|
D
L
 
V
L
 
L
Y
 
Y
H
 
H
L
 
A
M
 
M
V
 
V
L
 
L
L
 
L
E
 
A
A
 
L
R
 
K
N
 
D
V
 
V
P
 
K
I
 
V
E
 
E
A
 
E
V
 
V
F
 
L
A
 
Q
E
 
V
L
 
L
D
 
R
S
 
Q
R
 
R

Sites not aligning to the query:

7bgnA Crystal structure of mthisn2-amp complex, a bifunctional enzyme from the histidine biosynthetic pathway (see paper)
39% identity, 79% coverage: 5:92/111 of query aligns to 117:203/204 of 7bgnA

query
sites
7bgnA
T
 
S
L
 
L
A
 
Y
R
 
A
L
|
L
A
 
E
A
 
S
T
 
T
I
 
I
K
 
S
A
 
Q
R
|
R
R
 
K
A
 
A
S
 
E
T
 
V
A
 
V
S
 
-
A
 
P
S
|
S
Y
x
W
T
|
T
K
 
K
S
 
R
L
 
L
L
 
L
E
 
L
K
 
N
G
 
D
A
 
K
A
 
L
A
 
L
C
 
C
A
 
S
K
 
K
K
 
-
L
 
I
G
 
R
E
 
E
E
|
E
A
 
A
V
 
N
E
 
E
T
 
-
V
 
L
I
 
C
A
 
E
G
 
T
V
 
L
A
 
E
E
 
N
S
 
N
D
 
E
D
 
D
K
 
K
L
 
S
R
 
R
-
 
T
-
 
A
A
 
S
E
|
E
A
 
M
A
 
A
D
|
D
L
 
V
L
 
L
Y
|
Y
H
 
H
L
 
A
M
 
M
V
 
V
L
 
L
L
 
L
E
 
A
A
 
L
R
 
K
N
 
D
V
 
V
P
 
K
I
 
V
E
 
E
A
 
E
V
 
V
F
 
L
A
 
Q
E
 
V
L
 
L
D
 
R
S
 
Q
R
|
R

Sites not aligning to the query:

6j2lA Crystal structure of bi-functional enzyme (see paper)
37% identity, 59% coverage: 6:70/111 of query aligns to 114:178/200 of 6j2lA

query
sites
6j2lA
L
 
L
A
 
Y
R
 
Q
L
 
L
A
 
E
A
 
Q
T
 
L
I
 
L
K
 
A
A
 
E
R
 
R
R
 
K
A
 
Y
S
 
A
T
 
D
A
 
P
S
 
E
A
 
T
S
 
S
Y
 
Y
T
 
T
K
 
A
S
 
K
L
 
L
L
 
Y
E
 
A
K
 
S
G
 
G
A
 
T
A
 
K
A
 
R
C
 
I
A
 
A
K
 
Q
K
 
K
L
 
V
G
 
G
E
 
E
E
|
E
A
 
G
V
 
V
E
 
E
T
 
T
V
 
A
I
 
L
A
 
A
G
 
A
V
 
T
A
 
V
E
 
H
S
 
D
D
 
R
D
 
F
K
 
E
L
 
L
R
 
T
A
 
N
E
|
E
A
 
A
A
 
S
D
|
D
L
 
L
L
 
M
Y
 
Y
H
 
H

Sites not aligning to the query:

Query Sequence

>WP_013420262.1 NCBI__GCF_000166055.1:WP_013420262.1
MSEHTLARLAATIKARRASTASASYTKSLLEKGAAACAKKLGEEAVETVIAGVAESDDKL
RAEAADLLYHLMVLLEARNVPIEAVFAELDSRTAQSGHAEKASRPKDGSPS

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory