Comparing WP_013451107.1 NCBI__GCF_000183405.1:WP_013451107.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
5ey5A Lbcats
30% identity, 97% coverage: 5:230/232 of query aligns to 22:252/261 of 5ey5A
6uapC Crystal structure of tryptophan synthase from m. Tuberculosis - open form with brd6309 bound
26% identity, 91% coverage: 5:215/232 of query aligns to 22:227/250 of 6uapC
6usaA Crystal structure of tryptophan synthase from m. Tuberculosis - aminoacrylate- and gsk1-bound form (see paper)
26% identity, 91% coverage: 5:215/232 of query aligns to 23:226/249 of 6usaA
6u6cA Crystal structure of tryptophan synthase from m. Tuberculosis - aminoacrylate- and gsk2-bound form (see paper)
26% identity, 91% coverage: 5:215/232 of query aligns to 23:226/249 of 6u6cA
6dweA Crystal structure of tryptophan synthase from m. Tuberculosis - aminoacrylate- and brd0059-bound form
26% identity, 91% coverage: 5:215/232 of query aligns to 23:226/249 of 6dweA
5tciA Crystal structure of tryptophan synthase from m. Tuberculosis - brd4592-bound form (see paper)
26% identity, 91% coverage: 5:215/232 of query aligns to 23:226/249 of 5tciA
8b08A Tryptophan synthase - cryo-trapping by the spitrobot crystal plunger after 30 sec (see paper)
27% identity, 82% coverage: 26:215/232 of query aligns to 44:240/269 of 8b08A
Sites not aligning to the query:
1k3uA Crystal structure of wild-type tryptophan synthase complexed with n- [1h-indol-3-yl-acetyl]aspartic acid (see paper)
27% identity, 82% coverage: 26:215/232 of query aligns to 43:239/268 of 1k3uA
Sites not aligning to the query:
7jllA The internal aldimine crystal structure of salmonella typhimurium tryptophan synthase mutant beta-s377a in complex with inhibitor 2- ({[4-(trifluoromethoxy)phenyl]sulfonyl}amino)ethyl dihydrogen phosphate (f9f) at the alpha-site, cesium ion at the metal coordination site and l-tryptophan at the enzyme beta-site
27% identity, 82% coverage: 26:215/232 of query aligns to 42:238/267 of 7jllA
Sites not aligning to the query:
6xncA Salmonella typhimurium tryptophan synthase complexed with l-tryptophan and d-glycerol-3-phosphate (see paper)
27% identity, 82% coverage: 26:215/232 of query aligns to 42:238/267 of 6xncA
Sites not aligning to the query:
1tjpA Crystal structure of wild-type tryptophan synthase complexed with 1- [(2-hydroxylphenyl)amino]3-glycerolphosphate (see paper)
27% identity, 82% coverage: 26:215/232 of query aligns to 43:239/267 of 1tjpA
6u6cE Crystal structure of tryptophan synthase from m. Tuberculosis - aminoacrylate- and gsk2-bound form (see paper)
26% identity, 91% coverage: 5:215/232 of query aligns to 22:224/245 of 6u6cE
Sites not aligning to the query:
1cx9A Crystal structure of the complex of bacterial tryptophan synthase with the transition state analogue inhibitor 4-(2-aminophenylthio)- butylphosphonic acid (see paper)
27% identity, 82% coverage: 26:215/232 of query aligns to 42:236/264 of 1cx9A
1cw2A Crystal structure of the complex of bacterial tryptophan synthase with the transition state analogue inhibitor 4-(2-hydroxyphenylsulfinyl)- butylphosphonic acid (see paper)
27% identity, 82% coverage: 26:215/232 of query aligns to 42:236/264 of 1cw2A
Sites not aligning to the query:
1c9dA Crystal structure of the complex of bacterial tryptophan synthase with the transition state analogue inhibitor 4-(2-hydroxy-4- fluorophenylthio)-butylphosphonic acid (see paper)
27% identity, 82% coverage: 26:215/232 of query aligns to 42:236/264 of 1c9dA
1c29A Crystal structure of the complex of bacterial tryptophan synthase with the transition state analogue inhibitor 4-(2-hydroxyphenylthio)-1- butenylphosphonic acid (see paper)
27% identity, 82% coverage: 26:215/232 of query aligns to 42:236/264 of 1c29A
Sites not aligning to the query:
1a50A Crystal structure of wild-type tryptophan synthase complexed with 5- fluoroindole propanol phosphate (see paper)
28% identity, 81% coverage: 28:215/232 of query aligns to 44:232/260 of 1a50A
Sites not aligning to the query:
2trsA Crystal structures of mutant (betak87t) tryptophan synthase alpha2 beta2 complex with ligands bound to the active sites of the alpha and beta subunits reveal ligand-induced conformational changes (see paper)
28% identity, 81% coverage: 28:215/232 of query aligns to 45:233/262 of 2trsA
Sites not aligning to the query:
3cepA Structure of a tryptophan synthase quinonoid intermediate (see paper)
26% identity, 82% coverage: 26:215/232 of query aligns to 42:238/266 of 3cepA
Sites not aligning to the query:
2clkA Tryptophan synthase in complex with d-glyceraldehyde 3- phosphate (g3p) (see paper)
26% identity, 82% coverage: 26:215/232 of query aligns to 43:239/267 of 2clkA
Sites not aligning to the query:
>WP_013451107.1 NCBI__GCF_000183405.1:WP_013451107.1
MKGAYILADYPDRDLFIREFEYLCRSKVDFIEIGLPFNDPVADGPIIAKASNEVAERGYD
IDDIVDVIKLNNSKKIYIMTYANIIYNYGFERFSKRFESILDGVIVADLPNIGHEFFIKK
GFSLPLIPFATPESREKDLKKLNDFNGDFVYFIGIRGITGGEVDFKSENIKMKYSEIKSF
TDKKVIIGFGVKGVDDVSTILSYADGFVIGTEIVKRQDDFDEFKRYVDKIYL
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
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