SitesBLAST
Comparing WP_013451476.1 NCBI__GCF_000183405.1:WP_013451476.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
5b4tA Crystal structure of d-3-hydroxybutyrate dehydrogenase from alcaligenes faecalis complexed with NAD+ and a substrate d-3- hydroxybutyrate (see paper)
47% identity, 100% coverage: 1:251/252 of query aligns to 2:259/260 of 5b4tA
- active site: G15 (= G14), N114 (≠ M106), S142 (= S134), Y155 (= Y147), K159 (= K151), I200 (≠ Q192)
- binding (3R)-3-hydroxybutanoic acid: Q94 (= Q86), S142 (= S134), H144 (= H136), K152 (= K144), Y155 (= Y147), W187 (≠ Y179), Q196 (= Q188)
- binding nicotinamide-adenine-dinucleotide: G11 (= G10), T13 (≠ S12), G15 (= G14), I16 (= I15), F36 (vs. gap), D63 (= D55), L64 (= L56), N90 (= N82), G92 (= G84), L113 (= L105), I140 (= I132), Y155 (= Y147), K159 (= K151), P185 (= P177), G186 (≠ A178), W187 (≠ Y179), V188 (= V180), T190 (= T182), L192 (= L184), V193 (= V185)
3w8dA Crystal structure of d-3-hydroxybutyrate dehydrogenase from alcaligenes faecalis complexed with NAD+ and an inhibitor methylmalonate
47% identity, 100% coverage: 1:251/252 of query aligns to 2:259/260 of 3w8dA
- active site: G15 (= G14), N114 (≠ M106), S142 (= S134), Y155 (= Y147), K159 (= K151), I200 (≠ Q192)
- binding methylmalonic acid: Q94 (= Q86), S142 (= S134), H144 (= H136), K152 (= K144), Y155 (= Y147), W187 (≠ Y179), Q196 (= Q188), W257 (= W249)
- binding nicotinamide-adenine-dinucleotide: G11 (= G10), T13 (≠ S12), S14 (= S13), G15 (= G14), I16 (= I15), F36 (vs. gap), A62 (≠ V54), D63 (= D55), L64 (= L56), N90 (= N82), A91 (= A83), G92 (= G84), L113 (= L105), S142 (= S134), Y155 (= Y147), K159 (= K151), P185 (= P177), G186 (≠ A178), W187 (≠ Y179), V188 (= V180), T190 (= T182), L192 (= L184), V193 (= V185)
3vdrA Crystal structure of d-3-hydroxybutyrate dehydrogenase, prepared in the presence of the substrate d-3-hydroxybutyrate and NAD(+) (see paper)
47% identity, 100% coverage: 1:251/252 of query aligns to 2:259/260 of 3vdrA
- active site: G15 (= G14), N114 (≠ M106), S142 (= S134), Y155 (= Y147), K159 (= K151), I200 (≠ Q192)
- binding (3R)-3-hydroxybutanoic acid: Q94 (= Q86), H144 (= H136), K152 (= K144), Y155 (= Y147), W187 (≠ Y179), Q196 (= Q188), W257 (= W249)
- binding acetoacetic acid: Q94 (= Q86), H144 (= H136), K152 (= K144), Y155 (= Y147), W187 (≠ Y179), Q196 (= Q188), W257 (= W249)
- binding nicotinamide-adenine-dinucleotide: G11 (= G10), T13 (≠ S12), I16 (= I15), F36 (vs. gap), D63 (= D55), L64 (= L56), N90 (= N82), A91 (= A83), G92 (= G84), L113 (= L105), K159 (= K151), G186 (≠ A178), V188 (= V180), T190 (= T182), L192 (= L184), V193 (= V185)
- binding 1,4-dihydronicotinamide adenine dinucleotide: G11 (= G10), T13 (≠ S12), I16 (= I15), F36 (vs. gap), D63 (= D55), L64 (= L56), N90 (= N82), A91 (= A83), G92 (= G84), L113 (= L105), S142 (= S134), Y155 (= Y147), K159 (= K151), G186 (≠ A178), V188 (= V180), T190 (= T182), L192 (= L184), V193 (= V185)
3vdqA Crystal structure of alcaligenes faecalis d-3-hydroxybutyrate dehydrogenase in complex with NAD(+) and acetate (see paper)
47% identity, 100% coverage: 1:251/252 of query aligns to 2:259/260 of 3vdqA
- active site: G15 (= G14), N114 (≠ M106), S142 (= S134), Y155 (= Y147), K159 (= K151), I200 (≠ Q192)
- binding acetate ion: Q94 (= Q86), H144 (= H136), K152 (= K144), W187 (≠ Y179), L192 (= L184), Q196 (= Q188)
- binding nicotinamide-adenine-dinucleotide: G11 (= G10), S14 (= S13), I16 (= I15), F36 (vs. gap), D63 (= D55), L64 (= L56), N90 (= N82), A91 (= A83), G92 (= G84), L113 (= L105), I140 (= I132), S142 (= S134), Y155 (= Y147), K159 (= K151), P185 (= P177), G186 (≠ A178), W187 (≠ Y179), V188 (= V180), T190 (= T182), L192 (= L184), V193 (= V185)
2ztlA Closed conformation of d-3-hydroxybutyrate dehydrogenase complexed with NAD+ and l-3-hydroxybutyrate (see paper)
46% identity, 100% coverage: 1:251/252 of query aligns to 2:259/260 of 2ztlA
- active site: G15 (= G14), N114 (≠ M106), S142 (= S134), Y155 (= Y147), K159 (= K151), L200 (≠ Q192)
- binding (3s)-3-hydroxybutanoic acid: Q94 (= Q86), S142 (= S134), H144 (= H136), K152 (= K144), Y155 (= Y147), Q196 (= Q188)
- binding nicotinamide-adenine-dinucleotide: G11 (= G10), G15 (= G14), I16 (= I15), F36 (vs. gap), L64 (= L56), N90 (= N82), A91 (= A83), G92 (= G84), L113 (= L105), Y155 (= Y147), K159 (= K151), P185 (= P177), W187 (≠ Y179), V188 (= V180), T190 (= T182), V193 (= V185)
1wmbA Crystal structure of NAD dependent d-3-hydroxybutylate dehydrogenase (see paper)
46% identity, 100% coverage: 1:251/252 of query aligns to 2:259/260 of 1wmbA
5yssB Crystal structure of aminocaproic acid cyclase in complex with NAD (+) (see paper)
43% identity, 98% coverage: 4:251/252 of query aligns to 5:254/255 of 5yssB
- binding nicotinamide-adenine-dinucleotide: G11 (= G10), T13 (≠ S12), S14 (= S13), G15 (= G14), I16 (= I15), G35 (vs. gap), F36 (vs. gap), L60 (= L56), N86 (= N82), G88 (= G84), I89 (= I85), A137 (≠ N133), Y151 (= Y147), K155 (= K151), P181 (= P177), G182 (≠ A178), V184 (= V180), T186 (= T182)
2q2qD Structure of d-3-hydroxybutyrate dehydrogenase from pseudomonas putida (see paper)
44% identity, 100% coverage: 1:251/252 of query aligns to 2:254/255 of 2q2qD
- active site: G15 (= G14), S138 (= S134), Y151 (= Y147), K155 (= K151), R196 (≠ Q192)
- binding nicotinamide-adenine-dinucleotide: G11 (= G10), T13 (≠ S12), S14 (= S13), G15 (= G14), I16 (= I15), F36 (≠ I35), D59 (= D55), L60 (= L56), N86 (= N82), G88 (= G84), L109 (= L105), I136 (= I132), S138 (= S134), Y151 (= Y147), K155 (= K151), P181 (= P177), G182 (≠ A178), W183 (≠ Y179), V184 (= V180), T186 (= T182), L188 (= L184), V189 (= V185)
6zzsD Crystal structure of (r)-3-hydroxybutyrate dehydrogenase from acinetobacter baumannii complexed with NAD+ and 3-oxovalerate (see paper)
42% identity, 98% coverage: 4:251/252 of query aligns to 8:260/261 of 6zzsD
- active site: G18 (= G14), S143 (= S134), Y156 (= Y147)
- binding nicotinamide-adenine-dinucleotide: G14 (= G10), S17 (= S13), I19 (= I15), D38 (= D34), M39 (≠ I35), D64 (= D55), V65 (≠ L56), N91 (= N82), A92 (= A83), G93 (= G84), M141 (≠ I132), A142 (≠ N133), S143 (= S134), Y156 (= Y147), K160 (= K151), P186 (= P177), G187 (≠ A178), V189 (= V180), T191 (= T182), L193 (= L184)
- binding 3-oxidanylidenepentanoic acid: Q95 (= Q86), S143 (= S134), N145 (≠ H136), K153 (= K144), Y156 (= Y147), Q197 (= Q188)
6zzqA Crystal structure of (r)-3-hydroxybutyrate dehydrogenase from acinetobacter baumannii complexed with NAD+ and acetoacetate (see paper)
42% identity, 98% coverage: 4:251/252 of query aligns to 7:259/260 of 6zzqA
- active site: G17 (= G14), S142 (= S134), Y155 (= Y147)
- binding acetoacetic acid: Q94 (= Q86), S142 (= S134), K152 (= K144), Y155 (= Y147), Q196 (= Q188)
- binding nicotinamide-adenine-dinucleotide: G13 (= G10), S16 (= S13), G17 (= G14), I18 (= I15), D37 (= D34), M38 (≠ I35), D63 (= D55), V64 (≠ L56), N90 (= N82), A91 (= A83), G92 (= G84), M140 (≠ I132), A141 (≠ N133), S142 (= S134), Y155 (= Y147), K159 (= K151), Y187 (= Y179), V188 (= V180), T190 (= T182)
1x1tA Crystal structure of d-3-hydroxybutyrate dehydrogenase from pseudomonas fragi complexed with NAD+ (see paper)
43% identity, 100% coverage: 1:251/252 of query aligns to 2:235/236 of 1x1tA
- active site: G15 (= G14), N114 (≠ M106), S142 (= S134), Y155 (= Y147), K159 (= K151)
- binding cacodylate ion: S142 (= S134), H144 (= H136), Y155 (= Y147), W187 (≠ Y179), W233 (= W249)
- binding nicotinamide-adenine-dinucleotide: G11 (= G10), T13 (≠ S12), S14 (= S13), G15 (= G14), I16 (= I15), G35 (vs. gap), F36 (vs. gap), D63 (= D55), L64 (= L56), N90 (= N82), G92 (= G84), L113 (= L105), S142 (= S134), Y155 (= Y147), K159 (= K151), P185 (= P177), W187 (≠ Y179), V188 (= V180), T190 (= T182)
8dt1C Crystal structure of a putative d-beta-hydroxybutyrate dehydrogenase from burkholderia cenocepacia j2315 in complex with NAD
41% identity, 98% coverage: 4:249/252 of query aligns to 5:256/259 of 8dt1C
- binding nicotinamide-adenine-dinucleotide: G11 (= G10), S14 (= S13), G15 (= G14), I16 (= I15), D35 (= D34), L36 (≠ I35), M60 (vs. gap), V62 (≠ L56), N88 (= N82), A89 (= A83), M139 (≠ I132), Y154 (= Y147), K158 (= K151), P184 (= P177), G185 (≠ A178), F186 (≠ Y179), V187 (= V180), T189 (= T182)
6zzpA Crystal structure of (r)-3-hydroxybutyrate dehydrogenase from psychrobacter arcticus complexed with NAD+ and 3-oxovalerate (see paper)
38% identity, 98% coverage: 4:249/252 of query aligns to 11:262/265 of 6zzpA
- binding nicotinamide-adenine-dinucleotide: G17 (= G10), S20 (= S13), G21 (= G14), I22 (= I15), D41 (= D34), I42 (= I35), M66 (vs. gap), D67 (= D55), V68 (≠ L56), N94 (= N82), A95 (= A83), G96 (= G84), M145 (≠ I132), S147 (= S134), Y160 (= Y147), K164 (= K151), P190 (= P177), F192 (≠ Y179), V193 (= V180), T195 (= T182), L197 (= L184), V198 (= V185)
- binding 3-oxidanylidenepentanoic acid: Q98 (= Q86), S147 (= S134), H149 (= H136), K157 (= K144), Y160 (= Y147), F192 (≠ Y179), Q201 (= Q188)
6zzoC Crystal structure of (r)-3-hydroxybutyrate dehydrogenase from psychrobacter arcticus complexed with NAD+ and acetoacetate (see paper)
38% identity, 98% coverage: 4:249/252 of query aligns to 11:262/265 of 6zzoC
- binding acetoacetic acid: Q98 (= Q86), H149 (= H136), K157 (= K144), F192 (≠ Y179), Q201 (= Q188)
- binding nicotinamide-adenine-dinucleotide: G17 (= G10), S20 (= S13), G21 (= G14), I22 (= I15), D41 (= D34), I42 (= I35), M66 (vs. gap), D67 (= D55), V68 (≠ L56), N94 (= N82), A95 (= A83), G96 (= G84), M145 (≠ I132), Y160 (= Y147), K164 (= K151), P190 (= P177), F192 (≠ Y179), V193 (= V180), T195 (= T182), L197 (= L184), V198 (= V185)
6ixmC Crystal structure of the ketone reductase chkred20 from the genome of chryseobacterium sp. Ca49 complexed with NAD (see paper)
35% identity, 100% coverage: 1:251/252 of query aligns to 3:247/248 of 6ixmC
- active site: G16 (= G14), S142 (= S134), Y155 (= Y147), K159 (= K151)
- binding nicotinamide-adenine-dinucleotide: G12 (= G10), S15 (= S13), G16 (= G14), I17 (= I15), D36 (= D34), I37 (= I35), A61 (≠ V54), D62 (= D55), T63 (≠ L56), N89 (= N82), A90 (= A83), M140 (≠ I132), S142 (= S134), Y155 (= Y147), K159 (= K151), P185 (= P177), A186 (= A178), Y187 (= Y179), I188 (≠ V180), L192 (= L184)
8y83A Crystal structure of a ketoreductase from sphingobacterium siyangense sy1 with co-enzyme
36% identity, 100% coverage: 1:251/252 of query aligns to 4:248/249 of 8y83A
- binding nicotinamide-adenine-dinucleotide: G13 (= G10), S16 (= S13), G17 (= G14), I18 (= I15), D37 (= D34), I38 (= I35), A62 (≠ V54), D63 (= D55), S64 (≠ L56), N90 (= N82), M141 (≠ I132), Y156 (= Y147), K160 (= K151), P186 (= P177), G187 (≠ A178), Y188 (= Y179), I189 (≠ V180), L193 (= L184)
5itvA Crystal structure of bacillus subtilis bacc dihydroanticapsin 7- dehydrogenase in complex with nadh (see paper)
34% identity, 100% coverage: 1:251/252 of query aligns to 5:254/255 of 5itvA
- active site: G18 (= G14), S141 (= S134), Y154 (= Y147), K158 (= K151)
- binding 1,4-dihydronicotinamide adenine dinucleotide: G14 (= G10), S17 (= S13), G18 (= G14), I19 (= I15), D38 (= D34), I39 (= I35), T61 (≠ V54), I63 (≠ L56), N89 (= N82), G91 (= G84), T139 (≠ I132), S141 (= S134), Y154 (= Y147), K158 (= K151), P184 (= P177), G185 (≠ A178), I186 (≠ Y179), I187 (≠ V180)
4nbuB Crystal structure of fabg from bacillus sp (see paper)
36% identity, 98% coverage: 1:248/252 of query aligns to 5:241/244 of 4nbuB
- active site: G18 (= G14), N111 (≠ M106), S139 (= S134), Q149 (≠ K144), Y152 (= Y147), K156 (= K151)
- binding acetoacetyl-coenzyme a: D93 (≠ V88), K98 (≠ D93), S139 (= S134), N146 (≠ S141), V147 (≠ E142), Q149 (≠ K144), Y152 (= Y147), F184 (≠ Y179), M189 (≠ L184), K200 (≠ E206)
- binding 1,4-dihydronicotinamide adenine dinucleotide: G14 (= G10), N17 (≠ S13), G18 (= G14), I19 (= I15), D38 (= D34), F39 (≠ I35), V59 (= V54), D60 (= D55), V61 (≠ L56), N87 (= N82), A88 (= A83), G89 (= G84), I90 (= I85), T137 (≠ I132), S139 (= S134), Y152 (= Y147), K156 (= K151), P182 (= P177), F184 (≠ Y179), T185 (≠ V180), T187 (= T182), M189 (≠ L184)
4k6fB X-ray crystal structure of a putative acetoacetyl-coa reductase from burkholderia cenocepacia bound to the co-factor NADP
34% identity, 98% coverage: 3:248/252 of query aligns to 1:241/245 of 4k6fB
- active site: G12 (= G14), N102 (≠ K98), S138 (= S134), Y151 (= Y147), K155 (= K151)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G8 (= G10), Y32 (vs. gap), S33 (vs. gap), N36 (≠ D34), V58 (= V54), D59 (= D55), V60 (≠ L56), A87 (= A83), G88 (= G84), I89 (= I85)
1vl8B Crystal structure of gluconate 5-dehydrogenase (tm0441) from thermotoga maritima at 2.07 a resolution
32% identity, 100% coverage: 1:252/252 of query aligns to 4:252/252 of 1vl8B
- active site: G17 (= G14), S143 (= S134), I154 (vs. gap), Y157 (= Y147), K161 (= K151)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G13 (= G10), R16 (≠ S13), G17 (= G14), L18 (≠ I15), S37 (≠ D34), R38 (≠ I35), C63 (≠ V54), D64 (= D55), V65 (≠ L56), A91 (≠ N82), A92 (= A83), G93 (= G84), I94 (= I85), V114 (≠ L105), I141 (= I132), S143 (= S134), Y157 (= Y147), K161 (= K151), P187 (= P177), G188 (≠ A178), Y190 (≠ V180), T192 (= T182), M194 (≠ L184), T195 (≠ V185)
Query Sequence
>WP_013451476.1 NCBI__GCF_000183405.1:WP_013451476.1
MKEKVAVVTGASSGIGLSIAEQLSKAGCKVVMADINKEKGIEEANRIGAKFFQVDLSRRS
DCRDLIDFAGNSFGSVDILVNNAGIQHVSPVEDFPEDKWDFMISLMLTAPFLLTKYSWNY
MKEKKWGRIININSVHGLRASEFKSAYISAKHGLSGLTKTTALEGGKYGITVNSICPAYV
RTPLVDNQIDAQAKTHGIPREKVIEEIMLKKAYVKKLIEPSEVGSMVLYLCSDAAQCITG
SMITIDCGWTAS
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory