SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing WP_013451594.1 NCBI__GCF_000183405.1:WP_013451594.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

3bs8A Crystal structure of glutamate 1-semialdehyde aminotransferase complexed with pyridoxamine-5'-phosphate from bacillus subtilis (see paper)
58% identity, 100% coverage: 2:422/422 of query aligns to 8:428/430 of 3bs8A

query
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3bs8A

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active site: V22 (= V16), Y145 (= Y139), E207 (= E201), D240 (= D234), M243 (≠ I237), K268 (= K262), G401 (≠ A395)
binding 4'-deoxy-4'-aminopyridoxal-5'-phosphate: G118 (= G112), T119 (= T113), Y145 (= Y139), H146 (= H140), E207 (= E201), N212 (= N206), D240 (= D234), V242 (= V236), K268 (= K262)

Q42522 Glutamate-1-semialdehyde 2,1-aminomutase 2, chloroplastic; GSA 2; Glutamate-1-semialdehyde aminotransferase 2; GSA-AT 2; EC 5.4.3.8 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
58% identity, 99% coverage: 5:421/422 of query aligns to 55:472/472 of Q42522

query
sites
Q42522

F

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R92 (≠ Y42) mutation to K: In gsa2-1; suppression of enf1 mutant pleiotropic developmental phenotypes; when associated with S-162.
G162 (= G112) mutation to S: In gsa2-1; suppression of enf1 mutant pleiotropic developmental phenotypes; when associated with K-92.

P23893 Glutamate-1-semialdehyde 2,1-aminomutase; GSA; Glutamate-1-semialdehyde aminotransferase; GSA-AT; EC 5.4.3.8 from Escherichia coli (strain K12) (see paper)
56% identity, 100% coverage: 2:421/422 of query aligns to 5:426/426 of P23893

query
sites
P23893

K

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V

V

L

F

K

A

E

K

L

L

K265 (= K262) mutation to R: 2% of wild-type activity.

3k28A Crystal structure of a glutamate-1-semialdehyde aminotransferase from bacillus anthracis with bound pyridoxal 5'phosphate
58% identity, 95% coverage: 5:406/422 of query aligns to 11:407/423 of 3k28A

query
sites
3k28A

F

F

E

E

E

E

S

A

K

Q

R

D

Y

L

I

M

P

P

G

G

G

G

V
|
V

N

N

S

S

P

P

V

V

R

R

A

A

F

F

G

K

S

S

V

V

G

G

G

M

E

N

P

P

I

L

F

F

I

M

D

E

R

R

G

G

K

K

G

G

S

S

K

K

I

V

Y

Y

D

D

V

I

D

D

G

G

K

N

E

E

Y

Y

I

I

D

D

Y

Y

V

V

C

L

S

S

W

W

G

G

P

P

L

L

I

I

H

H

G

G

H

H

A

A

D

N

D

D

D

R

I

V

I

V

T

E

E

A

V

L

E

K

R

A

V

V

L

A

K

E

K

R

G

G

T

T

T

S

F

F

G

G

A

A

P

P

T

T

V

E

L

I

E

E

L

N

E

K

L

L

A

A

K

K

K

L

V

V

V
x
I

E

E

M

R

V
|
V

P
|
P

S

S

I
|
I

E

E

M

I

V

V

R

R

M

M

V

V

S

N

S

S

G
|
G

T
|
T

E

E

A

A

V

T

M

M

S

S

A

A

I

L

R

R

L

L

A

A

R

R

G

G

Y

Y

T

T

G

G

R

R

D

N

K

K

I

I

I

L

K

K

F

F

E

I

G

G

C

C

Y
|
Y

H
|
H

G
|
G

H

H

S

G

D

D

S

S

L

L

L

L

V

I

K

K

A

A

G

G

S

S

G

G

A

V

L

-

T

-

F

-

G

-

Q

-

P

P

S

D

S

S

P

P

G

G

V

V

P

P

A

E

D

G

L

V

A

A

K

K

H

N

T

T

L

I

I

T

A

V

D

A

Y

Y

N

N

D

D

L

L

N

E

S

S

V

V

K

K

Q

Y

L

A

F

F

I

E

N

Q

N

F

K

G

N

D

Q

D

I

I

A

A

C

C

V

V

I

I

V

V

E
|
E

P

P

V

V

A

A

G

G

N

N

M

M

G

G

V

V

V

V

L

P

P

P

E

Q

E

P

G

G

F

F

L

L

S

E

G

G

L

L

R

R

D

E

L

V

C

T

S

E

N

Q

E

N

G

G

A

A

L

L

L

L

I

I

F

F

D
|
D

E

E

V
|
V

I
x
M

T

T

G

G

F

F

R

R

L

V

A

A

P

Y

G

N

G

C

A

G

Q

Q

E

G

Y

Y

F

Y

N

G

V

V

M

T

P

P

D

D

I

L

T

T

T

C

L

L

G

G

K
|
K

I

V

L

I

G

G

G

G

G

G

L

L

P

P

V

V

G

G

A

A

Y

Y

G

G

G

G

R

K

K

A

E

E

I

I

M

M

E

R

K

Q

I

V

S

A

P

P

L

S

G

G

P

P

V

I

Y

Y

Q

Q

A

A

G

G

T

T

L

L

S

S

G

G

N

N

P

P

L

L

A

A

M

M

A

A

A

A

G

G

I

Y

A

E

N

T

L

L

N

V

K

Q

L

L

N

T

E

P

N

E

F

S

Y

Y

Y

V

E

E

L

F

R

E

K

R

K

K

S

A

Q

E

Y

M

L

L

W

E

N

A

G

G

F

L

K

R

N

K

N

A

C

A

R

E

E

K

L

H

K

G

L

I

N

P

Y

H

A

H

F

I

N

N

E

R

I

A

E

G

S

S

M

M

S

I

C

G

M

I

F

F

F

F

T

T

E

D

R

E

P

P

V

V

K

I

S

N

F

Y

K

D

D

A

A

A

L

K

T

S

S

S

D

N

T

L

K

Q

K

F

Y

F

A

A

A

A

F

Y

F

Y

H

R

G

E

M

M

L

V

K

E

K

Q

G

G

I

V

N

F

L

L

A

P

P

P

S

S

Q

Q

F

F

E

E

A
x
G

M

L

F

F

V

L

S

S

A

T

A

V

H

H

T

S

N

D

K

A

D

D

active site: V22 (= V16), Y145 (= Y139), E202 (= E201), D235 (= D234), M238 (≠ I237), K263 (= K262), G396 (≠ A395)
binding calcium ion: I103 (≠ V97), V106 (= V100), P107 (= P101), I109 (= I103)
binding pyridoxal-5'-phosphate: G118 (= G112), T119 (= T113), Y145 (= Y139), H146 (= H140), G147 (= G141), E202 (= E201), D235 (= D234), V237 (= V236), M238 (≠ I237), K263 (= K262)

P42799 Glutamate-1-semialdehyde 2,1-aminomutase 1, chloroplastic; AtGSA1; GSA 1; Glutamate-1-semialdehyde aminotransferase 1; GSA-AT 1; EC 5.4.3.8 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
57% identity, 99% coverage: 5:421/422 of query aligns to 57:474/474 of P42799

query
sites
P42799

F

F

E

N

E

A

S

A

K

K

R

N

Y

L

I

M

P

P

G

G

G

G

V

V

N

N

S

S

P

P

V

V

R

R

A

A

F

F

G

K

S

S

V

V

G

G

G

G

E

Q

P

P

I

V

F

L

I

I

D

D

R

S

G

V

K

K

G

G

S

S

K

K

I

M

Y

W

D

D

V

I

D

D

G

G

K

N

E

E

Y

Y

I

I

D

D

Y

Y

V

V

C

G

S

S

W

W

G

G

P

P

L

A

I

I

H

I

G

G

H

H

A

A

D

D

D

D

D

E

I

V

I

L

T

A

E

A

V

L

E

A

R

E

V

T

L

M

K

K

K

K

G

G

T

T

T

S

F

F

G

G

A

A

P

P

T

C

V

L

L

L

E

E

L

N

E

V

L

L

A

A

K

E

K

M

V

V

V

I

E

S

M

A

V

V

P

P

S

S

I

I

E

E

M

M

V

V

R

R

M

F

V

V

S

N

S

S

G

G

T

T

E

E

A

A

V

C

M

M

S

G

A

V

I

L

R

R

L

L

A

A

R

R

G

A

Y

F

T

T

G

N

R

K

D

E

K

K

I

F

I

I

K

K

F

F

E

E

G

G

C

C

Y

Y

H

H

G

G

H

H

S

A

D

N

S

A

L

F

L

L

V

V

K

K

A

A

G

G

S

S

G

G

A

V

L

A

T

T

F

L

G

G

Q

L

P

P

S

D

S

S

P

P

G

G

V

V

P

P

A

K

D

A

L

A

A

T

K

S

H

D

T

T

L

L

I

T

A

A

D

P

Y

Y

N

N

D

D

L

L

N

E

S

A

V

V

K

E

Q

K

L

L

F

F

I

A

N

A

N

H

K

K

N

G

Q

E

I

I

A

S

C

A

V

V

I

I

V

L

E

E

P

P

V

V

A

V

G

G

N

N

M

S

G

G

V

F

V

I

L

P

P

P

E

T

E

P

G

E

F

F

L

I

S

N

G

G

L

L

R

R

D

Q

L

L

C

T

S

K

N

D

E

N

G

G

A

V

L

L

L

L

I

I

F

F

D

D

E

E

V

V

I

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T

G

G

F

F

R

R

L

L

A

A

P

Y

G

G

G

G

A

A

Q

Q

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E

Y

Y

F

F

N

G

V

I

M

T

P

P

D

D

I

L

T

T

T

T

L

L

G

G

K
|
K

I

I

L

I

G

G

G

G

G

G

L

L

P

P

V

V

G

G

A

A

Y

Y

G

G

G

G

R

R

K

R

E

D

I

I

M

M

E

E

K

M

I

V

S

A

P

P

L

A

G

G

P

P

V

M

Y

Y

Q

Q

A

A

G

G

T

T

L

L

S

S

G

G

N

N

P

P

L

L

A

A

M

M

A

T

A

A

G

G

I

I

A

H

N

T

L

L

N

K

K

R

L

L

N

K

E

Q

N

A

F

G

Y

T

Y

Y

E

E

-

Y

L

L

R

D

K

K

K

I

S

T

Q

K

Y

E

L

L

W

T

N

N

G

G

F

I

K

L

N

E

N

A

C

G

R

K

E

K

L

T

K

G

L

H

N

P

Y

M

A

C

F

G

N

G

E

Y

I

I

E

S

S

G

M

M

S

F

C

G

M

F

F

F

F

F

T

A

E

E

R

G

P

P

V

V

K

Y

S

N

F

F

K

A

D

D

A

S

L

K

T

K

S

S

D

D

T

T

K

E

K

K

Y

F

A

G

A

R

F

F

F

F

H

R

G

G

M

M

L

L

K

E

K

E

G

G

I

V

N

Y

L

F

A

A

P

P

S

S

Q

Q

F

F

E

E

A

A

M

G

F

F

V

T

S

S

A

L

A

A

H

H

T

T

N

P

K

E

D

D

L

I

D

Q

A

L

T

T

I

I

K

A

A

A

H

A

Y

E

E

R

V

V

L

L

K

S

E

R

L

I

K314 (= K262) modified: N6-(pyridoxal phosphate)lysine

5hdmB Crystal structure of arabidopsis thaliana glutamate-1-semialdehyde-2, 1-aminomutase (see paper)
57% identity, 99% coverage: 5:421/422 of query aligns to 11:428/428 of 5hdmB

query
sites
5hdmB

F

F

E

N

E

A

S

A

K

K

R

N

Y

L

I

M

P

P

G

G

G

G

V
|
V

N

N

S

S

P

P

V

V

R

R

A

A

F

F

G

K

S

S

V

V

G

G

G

G

E

Q

P

P

I

V

F

L

I

I

D

D

R

S

G

V

K

K

G

G

S

S

K

K

I

M

Y

W

D

D

V

I

D

D

G

G

K

N

E

E

Y

Y

I

I

D

D

Y

Y

V

V

C

G

S

S

W

W

G

G

P

P

L

A

I

I

H

I

G

G

H

H

A

A

D

D

D

D

D

E

I

V

I

L

T

A

E

A

V

L

E

A

R

E

V

T

L

M

K

K

K

K

G

G

T

T

T

S

F

F

G

G

A

A

P

P

T

C

V

L

L

L

E

E

L

N

E

V

L

L

A

A

K

E

K

M

V

V

V

I

E

S

M

A

V

V

P

P

S

S

I

I

E

E

M

M

V

V

R

R

M

F

V

V

S

N

S

S

G
|
G

T
|
T

E

E

A

A

V

C

M

M

S

G

A

V

I

L

R

R

L

L

A

A

R

R

G

A

Y

F

T

T

G

N

R

K

D

E

K

K

I

F

I

I

K

K

F

F

E

E

G

G

C

C

Y
|
Y

H

H

G

G

H

H

S

A

D

N

S

A

L

F

L

L

V

V

K

K

A

A

G

G

S

S

G

G

A

V

L

A

T

T

F

L

G

G

Q

L

P

P

S

D

S

S

P

P

G

G

V

V

P

P

A

K

D

A

L

A

A

T

K

S

H

D

T

T

L

L

I

T

A

A

D

P

Y

Y

N

N

D

D

L

L

N

E

S

A

V

V

K

E

Q

K

L

L

F

F

I

A

N

A

N

H

K

K

N

G

Q

E

I

I

A

S

C

A

V

V

I

I

V

L

E
|
E

P

P

V

V

A

V

G

G

N
|
N

M

S

G

G

V

F

V

I

L

P

P

P

E

T

E

P

G

E

F

F

L

I

S

N

G

G

L

L

R

R

D

Q

L

L

C

T

S

K

N

D

E

N

G

G

A

V

L

L

L

L

I

I

F

F

D
|
D

E

E

V
|
V

I
x
M

T

T

G

G

F

F

R

R

L

L

A

A

P

Y

G

G

G

G

A

A

Q

Q

E

E

Y

Y

F

F

N

G

V

I

M

T

P

P

D

D

I

L

T

T

T

T

L

L

G

G

K
|
K

I

I

L

I

G

G

G

G

G

G

L

L

P

P

V

V

G

G

A

A

Y

Y

G

G

G

G

R

R

K

R

E

D

I

I

M

M

E

E

K

M

I

V

S

A

P

P

L

A

G

G

P

P

V

M

Y

Y

Q

Q

A

A

G

G

T

T

L

L

S

S

G

G

N

N

P

P

L

L

A

A

M

M

A

T

A

A

G

G

I

I

A

H

N

T

L

L

N

K

K

R

L

L

N

K

E

Q

N

A

F

G

Y

T

Y

Y

E

E

-

Y

L

L

R

D

K

K

K

I

S

T

Q

K

Y

E

L

L

W

T

N

N

G

G

F

I

K

L

N

E

N

A

C

G

R

K

E

K

L

T

K

G

L

H

N

P

Y

M

A

C

F

G

N

G

E

Y

I

I

E

S

S

G

M

M

S

F

C

G

M

F

F

F

F

F

T

A

E

E

R

G

P

P

V

V

K

Y

S

N

F

F

K

A

D

D

A

S

L

K

T

K

S

S

D

D

T

T

K

E

K

K

Y

F

A

G

A

R

F

F

F

F

H

R

G

G

M

M

L

L

K

E

K

E

G

G

I

V

N

Y

L

F

A

A

P

P

S

S

Q

Q

F

F

E

E

A
|
A

M

G

F

F

V

T

S

S

A

L

A

A

H

H

T

T

N

P

K

E

D

D

L

I

D

Q

A

L

T

T

I

I

K

A

A

A

H

A

Y

E

E

R

V

V

L

L

K

S

E

R

L

I

active site: V22 (= V16), Y145 (= Y139), E207 (= E201), D240 (= D234), M243 (≠ I237), K268 (= K262), A402 (= A395)
binding pyridoxal-5'-phosphate: G118 (= G112), T119 (= T113), Y145 (= Y139), E207 (= E201), N212 (= N206), D240 (= D234), V242 (= V236), M243 (≠ I237), K268 (= K262)
binding 4'-deoxy-4'-aminopyridoxal-5'-phosphate: G118 (= G112), T119 (= T113), Y145 (= Y139), E207 (= E201), N212 (= N206), D240 (= D234), V242 (= V236), M243 (≠ I237), K268 (= K262)

5hdmA Crystal structure of arabidopsis thaliana glutamate-1-semialdehyde-2, 1-aminomutase (see paper)
57% identity, 99% coverage: 5:421/422 of query aligns to 11:428/428 of 5hdmA

query
sites
5hdmA

F

F

E

N

E

A

S

A

K

K

R

N

Y

L

I

M

P

P

G

G

G

G

V
|
V

N

N

S

S

P

P

V

V

R

R

A

A

F

F

G

K

S

S

V

V

G

G

G

G

E

Q

P

P

I

V

F

L

I

I

D

D

R

S

G

V

K

K

G

G

S

S

K

K

I

M

Y

W

D

D

V

I

D

D

G

G

K

N

E

E

Y

Y

I

I

D

D

Y

Y

V

V

C

G

S

S

W

W

G

G

P

P

L

A

I

I

H

I

G

G

H

H

A

A

D

D

D

D

D

E

I

V

I

L

T

A

E

A

V

L

E

A

R

E

V

T

L

M

K

K

K

K

G

G

T

T

T

S

F

F

G

G

A

A

P

P

T

C

V

L

L

L

E

E

L

N

E

V

L

L

A

A

K

E

K

M

V

V

V

I

E

S

M

A

V

V

P

P

S

S

I

I

E

E

M

M

V

V

R

R

M

F

V

V

S

N

S

S

G
|
G

T
|
T

E

E

A

A

V

C

M

M

S

G

A

V

I

L

R

R

L

L

A

A

R

R

G

A

Y

F

T

T

G

N

R

K

D

E

K

K

I

F

I

I

K

K

F

F

E

E

G

G

C

C

Y
|
Y

H

H

G
|
G

H

H

S

A

D

N

S

A

L

F

L

L

V

V

K

K

A

A

G

G

S

S

G

G

A

V

L

A

T

T

F

L

G

G

Q

L

P

P

S

D

S

S

P

P

G

G

V

V

P

P

A

K

D

A

L

A

A

T

K

S

H

D

T

T

L

L

I

T

A

A

D

P

Y

Y

N

N

D

D

L

L

N

E

S

A

V

V

K

E

Q

K

L

L

F

F

I

A

N

A

N

H

K

K

N

G

Q

E

I

I

A

S

C

A

V

V

I

I

V

L

E
|
E

P

P

V

V

A

V

G

G

N
|
N

M

S

G

G

V

F

V

I

L

P

P

P

E

T

E

P

G

E

F

F

L

I

S

N

G

G

L

L

R

R

D

Q

L

L

C

T

S

K

N

D

E

N

G

G

A

V

L

L

L

L

I

I

F

F

D
|
D

E

E

V
|
V

I
x
M

T

T

G

G

F

F

R

R

L

L

A

A

P

Y

G

G

G

G

A

A

Q

Q

E

E

Y

Y

F

F

N

G

V

I

M

T

P

P

D

D

I

L

T

T

T

T

L

L

G

G

K
|
K

I

I

L

I

G

G

G

G

G

G

L

L

P

P

V

V

G

G

A

A

Y

Y

G

G

G

G

R

R

K

R

E

D

I

I

M

M

E

E

K

M

I

V

S

A

P

P

L

A

G

G

P

P

V

M

Y

Y

Q

Q

A

A

G

G

T

T

L

L

S

S

G

G

N

N

P

P

L

L

A

A

M

M

A

T

A

A

G

G

I

I

A

H

N

T

L

L

N

K

K

R

L

L

N

K

E

Q

N

A

F

G

Y

T

Y

Y

E

E

-

Y

L

L

R

D

K

K

K

I

S

T

Q

K

Y

E

L

L

W

T

N

N

G

G

F

I

K

L

N

E

N

A

C

G

R

K

E

K

L

T

K

G

L

H

N

P

Y

M

A

C

F

G

N

G

E

Y

I

I

E

S

S

G

M

M

S

F

C

G

M

F

F

F

F

F

T

A

E

E

R

G

P

P

V

V

K

Y

S

N

F

F

K

A

D

D

A

S

L

K

T

K

S

S

D

D

T

T

K

E

K

K

Y

F

A

G

A

R

F

F

F

F

H

R

G

G

M

M

L

L

K

E

K

E

G

G

I

V

N

Y

L

F

A

A

P

P

S

S

Q

Q

F

F

E

E

A
|
A

M

G

F

F

V

T

S

S

A

L

A

A

H

H

T

T

N

P

K

E

D

D

L

I

D

Q

A

L

T

T

I

I

K

A

A

A

H

A

Y

E

E

R

V

V

L

L

K

S

E

R

L

I

active site: V22 (= V16), Y145 (= Y139), E207 (= E201), D240 (= D234), M243 (≠ I237), K268 (= K262), A402 (= A395)
binding 4'-deoxy-4'-aminopyridoxal-5'-phosphate: G118 (= G112), T119 (= T113), Y145 (= Y139), G147 (= G141), E207 (= E201), N212 (= N206), D240 (= D234), V242 (= V236), K268 (= K262)

3fqaA Gabaculien complex of gabaculine resistant gsam version (see paper)
56% identity, 99% coverage: 3:421/422 of query aligns to 7:426/426 of 3fqaA

query
sites
3fqaA

N

E

L

I

F

F

E

A

E

A

S

A

K

Q

R

K

Y

L

I

M

P

P

G

G

G

G

V
|
V

N

S

S
|
S

P

P

V

V

R
|
R

A

A

F

F

G

K

S

S

V

V

G

G

G

G

E

Q

P

P

I

I

F

V

I

F

D

D

R

R

G

V

K

K

G

D

S

A

K

Y

I

A

Y

W

D

D

V

V

D

D

G

G

K

N

E

R

Y

Y

I

I

D

D

Y

Y

V

V

C

G

S

T

W
|
W

G

G

P

P

L

A

I

I

H

C

G

G

H

H

A

A

D

H

D

P

D

E

I

V

I

I

T

E

E

A

V

L

E

K

R

V

V

A

L

M

K

E

K

K

G

G

T

T

T

S

F

F

G

G

A

A

P

P

T

C

V

A

L

L

E

E

L

N

E

V

L

L

A

A

K

E

K

M

V

V

V

N

E

D

M

A

V

V

P

P

S

S

I

I

E

E

M

M

V

V

R

R

M

F

V

V

S

N

S

S

G
|
G

T
|
T

E

E

A

A

V

C

M

M

S

A

A

V

I

L

R

R

L

L

A

M

R

R

G

A

Y

Y

T

T

G

G

R

R

D

D

K

K

I

I

I

I

K

K

F

F

E

E

G

G

C

C

Y
|
Y

H

H

G

G

H

H

S

A

D

D

S

M

L

F

L

L

V

V

K

K

A

A

G

G

S

S

G

G

A

V

L

A

T

T

F

L

G

G

Q

L

P

P

S

S

S

S

P

P

G

G

V

V

P

P

A

K

D

K

L

T

A

T

K

A

H

N

T

T

L

L

I

T

A

T

D

P

Y

Y

N

N

D

D

L

L

N

E

S

A

V

V

K

K

Q

A

L

L

F

F

I

A

N

E

N

N

K

P

N

G

Q

E

I

I

A

A

C

G

V

V

I

I

V

L

E
|
E

P

P

V

I

A

V

G

G

N
|
N

M

S

G

G

V

F

V

I

L

V

P

P

E

D

E

A

G

G

F

F

L

L

S

E

G

G

L

L

R

R

D

E

L

I

C

T

S

L

N

E

E

H

G

D

A

A

L

L

L

L

I

V

F

F

D
|
D

E

E

V
|
V

I
|
I

T

T

G

G

F

F

R

R

L

I

A

A

P

Y

G

G

G

G

A

V

Q

Q

E

E

Y

K

F

F

N

G

V

V

M

T

P

P

D

D

I

L

T

T

T

T

L

L

G

G

K
|
K

I

I

L

I

G

G

G

G

G

G

L

L

P

P

V

V

G

G

A

A

Y

Y

G

G

G

G

R

K

K

R

E

E

I

I

M

M

E

Q

K

L

I

V

S

A

P

P

L

A

G

G

P

P

V

M

Y

Y

Q

Q

A

A

G

G

T

T

L

L

S

S

G

G

N

N

P

P

L

L

A

A

M

M

A

T

A

A

G

G

I

I

A

K

N

T

L

L

N

E

K

L

L

L

N

R

E

Q

N

P

F

G

Y

T

Y

Y

E

E

-

Y

L

L

R

D

K

Q

K

I

S

T

Q

K

Y

R

L

L

W

S

N

D

G

G

F

L

K

L

N

A

N

I

C

A

R

Q

E

E

L

T

K

G

L

H

N

A

Y

A

A

C

F

G

N

G

E

Q

I

V

E

S

S

G

M

M

S

F

C

G

M

F

F

F

F

F

T

T

E

E

R

G

P

P

V

V

K

H

S

N

F

Y

K

E

D

D

A

A

L

K

T

K

S

S

D

D

T

L

K

Q

K

K

Y

F

A

S

A

R

F

F

F

H

H

R

G

G

M

M

L

L

K

E

K

Q

G

G

I

I

N

Y

L

L

A

A

P

P

S

S

Q

Q

F

F

E

E

A
|
A

M

G

F

F

V

T

S

S

A

L

A

A

H

H

T

T

N

E

K

E

D

D

L

I

D

D

A

A

T

T

I

L

K

A

A

A

H

A

Y

R

E

T

V

V

L

M

K

S

E

A

L

L

active site: V20 (= V16), Y143 (= Y139), D238 (= D234), I241 (= I237), K266 (= K262), A400 (= A395)
binding 3-aminobenzoic acid: S22 (= S18), R25 (= R21), W60 (= W56)
binding 4'-deoxy-4'-aminopyridoxal-5'-phosphate: G116 (= G112), T117 (= T113), Y143 (= Y139), E205 (= E201), N210 (= N206), D238 (= D234), V240 (= V236), I241 (= I237)

2gsaB Crystal structure of glutamate-1-semialdehyde aminomutase (aminotransferase, wild-type form) (see paper)
55% identity, 99% coverage: 3:421/422 of query aligns to 8:427/427 of 2gsaB

query
sites
2gsaB

N

E

L

I

F

F

E

A

E

A

S

A

K

Q

R

K

Y

L

I

M

P

P

G

G

G

G

V
|
V

N

S

S

S

P

P

V

V

R

R

A

A

F

F

G

K

S

S

V

V

G

G

G

G

E

Q

P

P

I

I

F

V

I

F

D

D

R

R

G

V

K

K

G

D

S

A

K

Y

I

A

Y

W

D

D

V

V

D

D

G

G

K

N

E

R

Y

Y

I

I

D

D

Y

Y

V

V

C

G

S

T

W

W

G

G

P

P

L

A

I

I

H

C

G

G

H

H

A

A

D

H

D

P

D

E

I

V

I

I

T

E

E

A

V

L

E

K

R

V

V

A

L

M

K

E

K

K

G

G

T

T

T

S

F

F

G

G

A

A

P

P

T

C

V

A

L

L

E

E

L

N

E

V

L

L

A

A

K

E

K

M

V

V

V

N

E

D

M

A

V

V

P

P

S

S

I

I

E

E

M

M

V

V

R

R

M

F

V

V

S

N

S

S

G
|
G

T
|
T

E

E

A

A

V

C

M

M

S

A

A

V

I

L

R

R

L

L

A

M

R

R

G

A

Y

Y

T

T

G

G

R

R

D

D

K

K

I

I

I

I

K

K

F

F

E

E

G

G

C

C

Y
|
Y

H

H

G

G

H

H

S

A

D

D

S

M

L

F

L

L

V

V

K

K

A

A

G

G

S

S

G

G

A

V

L

A

T

T

F

L

G

G

Q

L

P

P

S

S

S

S

P

P

G

G

V

V

P

P

A

K

D

K

L

T

A

T

K

A

H

N

T

T

L

L

I

T

A

T

D

P

Y

Y

N

N

D

D

L

L

N

E

S

A

V

V

K

K

Q

A

L

L

F

F

I

A

N

E

N

N

K

P

N

G

Q

E

I

I

A

A

C

G

V

V

I

I

V

L

E
|
E

P

P

V

I

A

V

G

G

N
|
N

M

S

G

G

V

F

V

I

L

V

P

P

E

D

E

A

G

G

F

F

L

L

S

E

G

G

L

L

R

R

D

E

L

I

C

T

S

L

N

E

E

H

G

D

A

A

L

L

L

L

I

V

F

F

D
|
D

E

E

V
|
V

I
x
M

T

T

G

G

F

F

R

R

L

I

A

A

P

Y

G

G

G

G

A

V

Q

Q

E

E

Y

K

F

F

N

G

V

V

M

T

P

P

D

D

I

L

T

T

T

T

L

L

G

G

K
|
K

I

I

L

I

G

G

G

G

G

G

L

L

P

P

V

V

G

G

A

A

Y

Y

G

G

G

G

R

K

K

R

E

E

I

I

M

M

E

Q

K

L

I

V

S

A

P

P

L

A

G

G

P

P

V

M

Y

Y

Q

Q

A

A

G

G

T

T

L

L

S

S

G

G

N

N

P

P

L

L

A

A

M

M

A

T

A

A

G

G

I

I

A

K

N

T

L

L

N

E

K

L

L

L

N

R

E

Q

N

P

F

G

Y

T

Y

Y

E

E

-

Y

L

L

R

D

K

Q

K

I

S

T

Q

K

Y

R

L

L

W

S

N

D

G

G

F

L

K

L

N

A

N

I

C

A

R

Q

E

E

L

T

K

G

L

H

N

A

Y

A

A

C

F

G

N

G

E

Q

I

V

E

S

S

G

M

M

S

F

C

G

M

F

F

F

F

F

T

T

E

E

R

G

P

P

V

V

K

H

S

N

F

Y

K

E

D

D

A

A

L

K

T

K

S

S

D

D

T

L

K

Q

K

K

Y

F

A

S

A

R

F

F

F

H

H

R

G

G

M

M

L

L

K

E

K

Q

G

G

I

I

N

Y

L

L

A

A

P

P

S

S

Q

Q

F

F

E

E

A
|
A

M

G

F

F

V

T

S

S

A

L

A

A

H

H

T

T

N

E

K

E

D

D

L

I

D

D

A

A

T

T

I

L

K

A

A

A

H

A

Y

R

E

T

V

V

L

M

K

S

E

A

L

L

active site: V21 (= V16), Y144 (= Y139), E206 (= E201), D239 (= D234), M242 (≠ I237), K267 (= K262), A401 (= A395)
binding pyridoxal-5'-phosphate: G117 (= G112), T118 (= T113), Y144 (= Y139), E206 (= E201), N211 (= N206), D239 (= D234), V241 (= V236), M242 (≠ I237), K267 (= K262)

2gsaA Crystal structure of glutamate-1-semialdehyde aminomutase (aminotransferase, wild-type form) (see paper)
55% identity, 99% coverage: 3:421/422 of query aligns to 8:427/427 of 2gsaA

query
sites
2gsaA

N

E

L

I

F

F

E

A

E

A

S

A

K

Q

R

K

Y

L

I

M

P

P

G

G

G

G

V
|
V

N

S

S

S

P

P

V

V

R

R

A

A

F

F

G

K

S

S

V

V

G

G

G

G

E

Q

P

P

I

I

F

V

I

F

D

D

R

R

G

V

K

K

G

D

S

A

K

Y

I

A

Y

W

D

D

V

V

D

D

G

G

K

N

E

R

Y

Y

I

I

D

D

Y

Y

V

V

C

G

S

T

W

W

G

G

P

P

L

A

I

I

H

C

G

G

H

H

A

A

D

H

D

P

D

E

I

V

I

I

T

E

E

A

V

L

E

K

R

V

V

A

L

M

K

E

K

K

G

G

T

T

T

S

F

F

G

G

A

A

P

P

T

C

V

A

L

L

E

E

L

N

E

V

L

L

A

A

K

E

K

M

V

V

V

N

E

D

M

A

V

V

P

P

S

S

I

I

E

E

M

M

V

V

R

R

M

F

V

V

S

N

S

S

G
|
G

T
|
T

E

E

A

A

V

C

M

M

S

A

A

V

I

L

R

R

L

L

A

M

R

R

G

A

Y

Y

T

T

G

G

R

R

D

D

K

K

I

I

I

I

K

K

F

F

E

E

G

G

C

C

Y
|
Y

H
|
H

G
|
G

H

H

S

A

D

D

S

M

L

F

L

L

V

V

K

K

A

A

G

G

S

S

G

G

A

V

L

A

T

T

F

L

G

G

Q

L

P

P

S

S

S

S

P

P

G

G

V

V

P

P

A

K

D

K

L

T

A

T

K

A

H

N

T

T

L

L

I

T

A

T

D

P

Y

Y

N

N

D

D

L

L

N

E

S

A

V

V

K

K

Q

A

L

L

F

F

I

A

N

E

N

N

K

P

N

G

Q

E

I

I

A

A

C

G

V

V

I

I

V

L

E
|
E

P

P

V

I

A

V

G

G

N
|
N

M

S

G

G

V

F

V

I

L

V

P

P

E

D

E

A

G

G

F

F

L

L

S

E

G

G

L

L

R

R

D

E

L

I

C

T

S

L

N

E

E

H

G

D

A

A

L

L

L

L

I

V

F

F

D
|
D

E

E

V
|
V

I
x
M

T

T

G

G

F

F

R

R

L

I

A

A

P

Y

G

G

G

G

A

V

Q

Q

E

E

Y

K

F

F

N

G

V

V

M

T

P

P

D

D

I

L

T

T

T

T

L

L

G

G

K
|
K

I

I

L

I

G

G

G

G

G

G

L

L

P

P

V

V

G

G

A

A

Y

Y

G

G

G

G

R

K

K

R

E

E

I

I

M

M

E

Q

K

L

I

V

S

A

P

P

L

A

G

G

P

P

V

M

Y

Y

Q

Q

A

A

G

G

T

T

L

L

S

S

G

G

N

N

P

P

L

L

A

A

M

M

A

T

A

A

G

G

I

I

A

K

N

T

L

L

N

E

K

L

L

L

N

R

E

Q

N

P

F

G

Y

T

Y

Y

E

E

-

Y

L

L

R

D

K

Q

K

I

S

T

Q

K

Y

R

L

L

W

S

N

D

G

G

F

L

K

L

N

A

N

I

C

A

R

Q

E

E

L

T

K

G

L

H

N

A

Y

A

A

C

F

G

N

G

E

Q

I

V

E

S

S

G

M

M

S

F

C

G

M

F

F

F

F

F

T

T

E

E

R

G

P

P

V

V

K

H

S

N

F

Y

K

E

D

D

A

A

L

K

T

K

S

S

D

D

T

L

K

Q

K

K

Y

F

A

S

A

R

F

F

F

H

H

R

G

G

M

M

L

L

K

E

K

Q

G

G

I

I

N

Y

L

L

A

A

P

P

S

S

Q

Q

F

F

E

E

A
|
A

M

G

F

F

V

T

S

S

A

L

A

A

H

H

T

T

N

E

K

E

D

D

L

I

D

D

A

A

T

T

I

L

K

A

A

A

H

A

Y

R

E

T

V

V

L

M

K

S

E

A

L

L

active site: V21 (= V16), Y144 (= Y139), E206 (= E201), D239 (= D234), M242 (≠ I237), K267 (= K262), A401 (= A395)
binding 4'-deoxy-4'-aminopyridoxal-5'-phosphate: G117 (= G112), T118 (= T113), Y144 (= Y139), H145 (= H140), G146 (= G141), N211 (= N206), D239 (= D234), V241 (= V236), K267 (= K262)

3usfA Crystal structure of dava-4
55% identity, 99% coverage: 3:421/422 of query aligns to 8:427/427 of 3usfA

query
sites
3usfA

N

E

L

I

F

F

E

A

E

A

S

A

K

Q

R

K

Y

L

I

M

P

P

G

G

G

G

V
|
V

N

S

S
|
S

P

P

V
|
V

R

R

A

A

F

F

G

K

S

S

V

V

G

G

G

G

E

Q

P

P

I

I

F

V

I

F

D

D

R

R

G

V

K

K

G

D

S

A

K

Y

I

A

Y

W

D

D

V

V

D

D

G

G

K

N

E

R

Y

Y

I

I

D

D

Y

Y

V

V

C

G

S

T

W

W

G

G

P

P

L

A

I

I

H

C

G

G

H

H

A

A

D

H

D

P

D

E

I

V

I

I

T

E

E

A

V

L

E

K

R

V

V

A

L

M

K

E

K

K

G

G

T

T

T

S

F

F

G

G

A

A

P

P

T

C

V

A

L

L

E

E

L

N

E

V

L

L

A

A

K

E

K

M

V

V

V

N

E

D

M

A

V

V

P

P

S

S

I

I

E

E

M

M

V

V

R

R

M

F

V

V

S

N

S

S

G
|
G

T
|
T

E

E

A

A

V

C

M

M

S

A

A

V

I

L

R

R

L

I

A

M

R

R

G

A

Y

Y

T

T

G

G

R

R

D

D

K

K

I

I

I

I

K

K

F

F

E

E

G

G

C

C

Y
|
Y

H

H

G

G

H

H

S

A

D

D

S

M

L

F

L

L

V

V

K

K

A

A

G

G

S
|
S

G

G

A

V

L

A

T

T

F

L

G

G

Q

L

P

P

S

S

S

S

P

P

G

G

V

V

P

P

A

K

D

K

L

T

A

T

K

A

H

N

T

T

L

L

I

T

A

T

D

P

Y

Y

N

N

D

D

L

L

N

E

S

A

V

V

K

K

Q

A

L

L

F

F

I

A

N

E

N

N

K

P

N

G

Q

E

I

I

A

A

C

G

V

V

I

I

V

L

E

E

P

P

V

I

A

V

G

G

N
|
N

M

S

G

G

V

F

V

I

L

V

P

P

E

D

E

A

G

G

F

F

L

L

S

E

G

G

L

L

R

R

D

E

L

I

C

T

S

L

N

E

E

H

G

D

A

A

L

L

L

L

I

V

F

F

D
|
D

E

E

V
|
V

I
x
M

T

T

G

G

F

F

R

R

L

I

A

A

P

Y

G

G

G

G

A

V

Q

Q

E

E

Y

K

F

F

N

G

V

V

M

T

P

P

D

D

I

L

T

T

T

T

L

L

G

G

K
|
K

I

I

L

I

G

G

G

G

G

G

L

L

P

P

V

V

G

G

A

A

Y

Y

G

G

G

G

R

K

K

R

E

E

I

I

M

M

E

Q

K

L

I

V

S

A

P

P

L

A

G

G

P

P

V

M

Y

Y

Q

Q

A

A

G

G

T

T

L

L

S

S

G

G

N

N

P

P

L

L

A

A

M

M

A

T

A

A

G

G

I

I

A

K

N

T

L

L

N

E

K

L

L

L

N

R

E

Q

N

P

F

G

Y

T

Y

Y

E

E

-

Y

L

L

R

D

K

Q

K

I

S

T

Q

K

Y

R

L

L

W

S

N

D

G

G

F

L

K

L

N

A

N

I

C

A

R

Q

E

E

L

T

K

G

L

H

N

A

Y

A

A

C

F

G

N

G

E

Q

I

V

E

S

S

G

M

M

S

F

C

G

M

F

F

F

F

F

T

T

E

E

R

G

P

P

V

V

K

H

S

N

F

Y

K

E

D

D

A

A

L

K

T

K

S

S

D

D

T

L

K

Q

K

K

Y

F

A

S

A

R

F

F

F

H

H

R

G

G

M

M

L

L

K

E

K

Q

G

G

I

I

N

Y

L

L

A

A

P

P

S

S

Q

Q

F

F

E
|
E

A
|
A

M

G

F

F

V

T

S

S

A

L

A

A

H

H

T

T

N

E

K

E

D

D

L

I

D

D

A

A

T

T

I

L

K

A

A

A

H

A

Y

R

E

T

V

V

L

M

K

S

E

A

L

L

active site: V21 (= V16), Y144 (= Y139), D239 (= D234), M242 (≠ I237), K267 (= K262), A401 (= A395)
binding (4s)-4,5-diaminopentanoic acid: S23 (= S18), V25 (= V20), S157 (= S152), K267 (= K262), E400 (= E394)
binding (5-hydroxy-4,6-dimethylpyridin-3-yl)methyl dihydrogen phosphate: G117 (= G112), T118 (= T113), Y144 (= Y139), N211 (= N206), D239 (= D234), V241 (= V236), K267 (= K262)

3fq7A Gabaculine complex of gsam (see paper)
55% identity, 99% coverage: 3:421/422 of query aligns to 8:427/427 of 3fq7A

query
sites
3fq7A

N

E

L

I

F

F

E

A

E

A

S

A

K

Q

R

K

Y

L

I

M

P

P

G

G

G

G

V
|
V

N

S

S
|
S

P

P

V
|
V

R

R

A

A

F

F

G

K

S

S

V

V

G

G

G

G

E

Q

P

P

I

I

F

V

I

F

D

D

R

R

G

V

K

K

G

D

S

A

K

Y

I

A

Y

W

D

D

V

V

D

D

G

G

K

N

E

R

Y

Y

I

I

D

D

Y

Y

V

V

C

G

S

T

W
|
W

G

G

P

P

L

A

I

I

H

C

G

G

H

H

A

A

D

H

D

P

D

E

I

V

I

I

T

E

E

A

V

L

E

K

R

V

V

A

L

M

K

E

K

K

G

G

T

T

T

S

F

F

G

G

A

A

P

P

T

C

V

A

L

L

E

E

L

N

E

V

L

L

A

A

K

E

K

M

V

V

V

N

E

D

M

A

V

V

P

P

S

S

I

I

E

E

M

M

V

V

R

R

M

F

V

V

S

N

S

S

G
|
G

T
|
T

E

E

A

A

V

C

M

M

S

A

A

V

I

L

R

R

L

I

A

M

R

R

G

A

Y

Y

T

T

G

G

R

R

D

D

K

K

I

I

I

I

K

K

F

F

E

E

G

G

C

C

Y
|
Y

H
|
H

G

G

H

H

S

A

D

D

S

M

L

F

L

L

V

V

K

K

A

A

G

G

S

S

G

G

A

V

L

A

T

T

F

L

G

G

Q

L

P

P

S

S

S

S

P

P

G

G

V

V

P

P

A

K

D

K

L

T

A

T

K

A

H

N

T

T

L

L

I

T

A

T

D

P

Y

Y

N

N

D

D

L

L

N

E

S

A

V

V

K

K

Q

A

L

L

F

F

I

A

N

E

N

N

K

P

N

G

Q

E

I

I

A

A

C

G

V

V

I

I

V

L

E
|
E

P

P

V

I

A

V

G

G

N
|
N

M

S

G

G

V

F

V

I

L

V

P

P

E

D

E

A

G

G

F

F

L

L

S

E

G

G

L

L

R

R

D

E

L

I

C

T

S

L

N

E

E

H

G

D

A

A

L

L

L

L

I

V

F

F

D
|
D

E

E

V
|
V

I
x
M

T

T

G

G

F

F

R

R

L

I

A

A

P

Y

G

G

G

G

A

V

Q

Q

E

E

Y

K

F

F

N

G

V

V

M

T

P

P

D

D

I

L

T

T

T

T

L

L

G

G

K
|
K

I

I

L

I

G

G

G

G

G

G

L

L

P

P

V

V

G

G

A

A

Y

Y

G

G

G

G

R

K

K

R

E

E

I

I

M

M

E

Q

K

L

I

V

S

A

P

P

L

A

G

G

P

P

V

M

Y

Y

Q

Q

A

A

G
|
G

T
|
T

L

L

S

S

G

G

N

N

P

P

L

L

A

A

M

M

A

T

A

A

G

G

I

I

A

K

N

T

L

L

N

E

K

L

L

L

N

R

E

Q

N

P

F

G

Y

T

Y

Y

E

E

-

Y

L

L

R

D

K

Q

K

I

S

T

Q

K

Y

R

L

L

W

S

N

D

G

G

F

L

K

L

N

A

N

I

C

A

R

Q

E

E

L

T

K

G

L

H

N

A

Y

A

A

C

F

G

N

G

E

Q

I

V

E

S

S

G

M

M

S

F

C

G

M

F

F

F

F

F

T

T

E

E

R

G

P

P

V

V

K

H

S

N

F

Y

K

E

D

D

A

A

L

K

T

K

S

S

D

D

T

L

K

Q

K

K

Y

F

A

S

A

R

F

F

F

H

H

R

G

G

M

M

L

L

K

E

K

Q

G

G

I

I

N

Y

L

L

A

A

P

P

S

S

Q

Q

F

F

E
|
E

A
|
A

M

G

F

F

V

T

S

S

A

L

A

A

H

H

T

T

N

E

K

E

D

D

L

I

D

D

A

A

T

T

I

L

K

A

A

A

H

A

Y

R

E

T

V

V

L

M

K

S

E

A

L

L

active site: V21 (= V16), Y144 (= Y139), D239 (= D234), M242 (≠ I237), K267 (= K262), A401 (= A395)
binding 3-[o-phosphonopyridoxyl]--amino-benzoic acid: S23 (= S18), V25 (= V20), W61 (= W56), G117 (= G112), T118 (= T113), Y144 (= Y139), H145 (= H140), E206 (= E201), N211 (= N206), D239 (= D234), V241 (= V236), M242 (≠ I237), K267 (= K262), G298 (= G293), T299 (= T294), E400 (= E394)

2hp2A Inter-subunit signaling in gsam (see paper)
55% identity, 99% coverage: 3:421/422 of query aligns to 8:427/427 of 2hp2A

query
sites
2hp2A

N

E

L

I

F

F

E

A

E

A

S

A

K

Q

R

K

Y

L

I

M

P

P

G

G

G

G

V
|
V

N

S

S
|
S

P

P

V

V

R

R

A

A

F

F

G

K

S

S

V

V

G

G

G

G

E

Q

P

P

I

I

F

V

I

F

D

D

R

R

G

V

K

K

G

D

S

A

K

Y

I

A

Y

W

D

D

V

V

D

D

G

G

K

N

E

R

Y

Y

I

I

D

D

Y

Y

V

V

C

G

S

T

W

W

G

G

P

P

L

A

I

I

H

C

G

G

H

H

A

A

D

H

D

P

D

E

I

V

I

I

T

E

E

A

V

L

E

K

R

V

V

A

L

M

K

E

K

K

G

G

T

T

T

S

F

F

G

G

A

A

P

P

T

C

V

A

L

L

E

E

L

N

E

V

L

L

A

A

K

E

K

M

V

V

V

N

E

D

M

A

V

V

P

P

S

S

I

I

E

E

M

M

V

V

R

R

M

F

V

V

S

N

S

S

G
|
G

T
|
T

E

E

A

A

V

C

M

M

S

A

A

V

I

L

R

R

L

I

A

M

R

R

G

A

Y

Y

T

T

G

G

R

R

D

D

K

K

I

I

I

I

K

K

F

F

E

E

G

G

C

C

Y
|
Y

H
|
H

G

G

H

H

S

A

D

D

S

M

L

F

L

L

V

V

K

K

A

A

G

G

S

S

G

G

A

V

L

A

T

T

F

L

G

G

Q

L

P

P

S

S

S

S

P

P

G

G

V

V

P

P

A

K

D

K

L

T

A

T

K

A

H

N

T

T

L

L

I

T

A

T

D

P

Y

Y

N

N

D

D

L

L

N

E

S

A

V

V

K

K

Q

A

L

L

F

F

I

A

N

E

N

N

K

P

N

G

Q

E

I

I

A

A

C

G

V

V

I

I

V

L

E
|
E

P

P

V

I

A

V

G

G

N
|
N

M

S

G

G

V

F

V

I

L

V

P

P

E

D

E

A

G

G

F

F

L

L

S

E

G

G

L

L

R

R

D

E

L

I

C

T

S

L

N

E

E

H

G

D

A

A

L

L

L

L

I

V

F

F

D
|
D

E

E

V
|
V

I
x
M

T

T

G

G

F

F

R

R

L

I

A

A

P

Y

G

G

G

G

A

V

Q

Q

E

E

Y

K

F

F

N

G

V

V

M

T

P

P

D

D

I

L

T

T

T

T

L

L

G

G

K
|
K

I

I

L

I

G

G

G

G

G

G

L

L

P

P

V

V

G

G

A

A

Y

Y

G

G

G

G

R

K

K

R

E

E

I

I

M

M

E

Q

K

L

I

V

S

A

P

P

L

A

G

G

P

P

V

M

Y

Y

Q

Q

A

A

G
|
G

T
|
T

L

L

S

S

G

G

N

N

P

P

L

L

A

A

M

M

A

T

A

A

G

G

I

I

A

K

N

T

L

L

N

E

K

L

L

L

N

R

E

Q

N

P

F

G

Y

T

Y

Y

E

E

-

Y

L

L

R

D

K

Q

K

I

S

T

Q

K

Y

R

L

L

W

S

N

D

G

G

F

L

K

L

N

A

N

I

C

A

R

Q

E

E

L

T

K

G

L

H

N

A

Y

A

A

C

F

G

N

G

E

Q

I

V

E

S

S

G

M

M

S

F

C

G

M

F

F

F

F

F

T

T

E

E

R

G

P

P

V

V

K

H

S

N

F

Y

K

E

D

D

A

A

L

K

T

K

S

S

D

D

T

L

K

Q

K

K

Y

F

A

S

A

R

F

F

F

H

H

R

G

G

M

M

L

L

K

E

K

Q

G

G

I

I

N

Y

L

L

A

A

P

P

S

S

Q

Q

F

F

E

E

A
|
A

M

G

F

F

V

T

S

S

A

L

A

A

H

H

T

T

N

E

K

E

D

D

L

I

D

D

A

A

T

T

I

L

K

A

A

A

H

A

Y

R

E

T

V

V

L

M

K

S

E

A

L

L

active site: V21 (= V16), Y144 (= Y139), D239 (= D234), M242 (≠ I237), K267 (= K262), A401 (= A395)
binding (4s)-4,5-diaminopentanoic acid: G298 (= G293), T299 (= T294)
binding (4r)-5-amino-4-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino]pentanoic acid: S23 (= S18), G117 (= G112), T118 (= T113), Y144 (= Y139), H145 (= H140), E206 (= E201), N211 (= N206), D239 (= D234), V241 (= V236), M242 (≠ I237), K267 (= K262)
binding pyridoxal-5'-phosphate: G298 (= G293), T299 (= T294)

2hp1A Inter-subunit signaling in gsam (see paper)
55% identity, 99% coverage: 3:421/422 of query aligns to 8:427/427 of 2hp1A

query
sites
2hp1A

N

E

L

I

F

F

E

A

E

A

S

A

K

Q

R

K

Y

L

I

M

P

P

G

G

G

G

V
|
V

N

S

S
|
S

P

P

V
|
V

R

R

A

A

F

F

G

K

S

S

V

V

G

G

G

G

E

Q

P

P

I

I

F

V

I

F

D

D

R

R

G

V

K

K

G

D

S

A

K

Y

I

A

Y

W

D

D

V

V

D

D

G

G

K

N

E

R

Y

Y

I

I

D

D

Y

Y

V

V

C

G

S

T

W
|
W

G

G

P

P

L

A

I

I

H

C

G

G

H

H

A

A

D

H

D

P

D

E

I

V

I

I

T

E

E

A

V

L

E

K

R

V

V

A

L

M

K

E

K

K

G

G

T

T

T

S

F

F

G

G

A

A

P

P

T

C

V

A

L

L

E

E

L

N

E

V

L

L

A

A

K

E

K

M

V

V

V

N

E

D

M

A

V

V

P

P

S

S

I

I

E

E

M

M

V

V

R

R

M

F

V

V

S

N

S
|
S

G
|
G

T
|
T

E

E

A

A

V

C

M

M

S

A

A

V

I

L

R

R

L

I

A

M

R

R

G

A

Y

Y

T

T

G

G

R

R

D

D

K

K

I

I

I

I

K

K

F

F

E

E

G

G

C

C

Y
|
Y

H
|
H

G
|
G

H

H

S

A

D

D

S

M

L

F

L

L

V

V

K

K

A

A

G

G

S

S

G

G

A

V

L

A

T

T

F

L

G

G

Q

L

P

P

S

S

S

S

P

P

G

G

V

V

P

P

A

K

D

K

L

T

A

T

K

A

H

N

T

T

L

L

I

T

A

T

D

P

Y

Y

N

N

D

D

L

L

N

E

S

A

V

V

K

K

Q

A

L

L

F

F

I

A

N

E

N

N

K

P

N

G

Q

E

I

I

A

A

C

G

V

V

I

I

V

L

E
|
E

P

P

V

I

A

V

G

G

N
|
N

M

S

G

G

V

F

V

I

L

V

P

P

E

D

E

A

G

G

F

F

L

L

S

E

G

G

L

L

R

R

D

E

L

I

C

T

S

L

N

E

E

H

G

D

A

A

L

L

L

L

I

V

F

F

D
|
D

E

E

V
|
V

I
x
M

T

T

G

G

F

F

R

R

L

I

A

A

P

Y

G

G

G

G

A

V

Q

Q

E

E

Y

K

F

F

N

G

V

V

M

T

P

P

D

D

I

L

T

T

T

T

L

L

G

G

K
|
K

I

I

L

I

G

G

G

G

G

G

L

L

P

P

V

V

G

G

A

A

Y

Y

G

G

G

G

R

K

K

R

E

E

I

I

M

M

E

Q

K

L

I

V

S

A

P

P

L

A

G

G

P

P

V

M

Y

Y

Q

Q

A

A

G

G

T

T

L

L

S

S

G

G

N

N

P

P

L

L

A

A

M

M

A

T

A

A

G

G

I

I

A

K

N

T

L

L

N

E

K

L

L

L

N

R

E

Q

N

P

F

G

Y

T

Y

Y

E

E

-

Y

L

L

R

D

K

Q

K

I

S

T

Q

K

Y

R

L

L

W

S

N

D

G

G

F

L

K

L

N

A

N

I

C

A

R

Q

E

E

L

T

K

G

L

H

N

A

Y

A

A

C

F

G

N

G

E

Q

I

V

E

S

S

G

M

M

S

F

C

G

M

F

F

F

F

F

T

T

E

E

R

G

P

P

V

V

K

H

S

N

F

Y

K

E

D

D

A

A

L

K

T

K

S

S

D

D

T

L

K

Q

K

K

Y

F

A

S

A

R

F

F

F

H

H

R

G

G

M

M

L

L

K

E

K

Q

G

G

I

I

N

Y

L

L

A

A

P

P

S

S

Q

Q

F

F

E
|
E

A
|
A

M

G

F

F

V

T

S

S

A

L

A

A

H

H

T

T

N

E

K

E

D

D

L

I

D

D

A

A

T

T

I

L

K

A

A

A

H

A

Y

R

E

T

V

V

L

M

K

S

E

A

L

L

active site: V21 (= V16), Y144 (= Y139), D239 (= D234), M242 (≠ I237), K267 (= K262), A401 (= A395)
binding (4s)-4-amino-5-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino]pentanoic acid: S23 (= S18), V25 (= V20), W61 (= W56), S116 (= S111), G117 (= G112), T118 (= T113), Y144 (= Y139), H145 (= H140), G146 (= G141), E206 (= E201), N211 (= N206), D239 (= D234), V241 (= V236), M242 (≠ I237), K267 (= K262), E400 (= E394)

2hozA Inter-subunit signaling in gsam (see paper)
55% identity, 99% coverage: 3:421/422 of query aligns to 8:427/427 of 2hozA

query
sites
2hozA

N

E

L

I

F

F

E

A

E

A

S

A

K

Q

R

K

Y

L

I

M

P

P

G

G

G

G

V
|
V

N

S

S

S

P

P

V

V

R

R

A

A

F

F

G

K

S

S

V

V

G

G

G

G

E

Q

P

P

I

I

F

V

I

F

D

D

R

R

G

V

K

K

G

D

S

A

K

Y

I

A

Y

W

D

D

V

V

D

D

G

G

K

N

E

R

Y

Y

I

I

D

D

Y

Y

V

V

C

G

S

T

W

W

G

G

P

P

L

A

I

I

H

C

G

G

H

H

A

A

D

H

D

P

D

E

I

V

I

I

T

E

E

A

V

L

E

K

R

V

V

A

L

M

K

E

K

K

G

G

T

T

T

S

F

F

G

G

A

A

P

P

T

C

V

A

L

L

E

E

L

N

E

V

L

L

A

A

K

E

K

M

V

V

V

N

E

D

M

A

V

V

P

P

S

S

I

I

E

E

M

M

V

V

R

R

M

F

V

V

S

N

S

S

G
|
G

T
|
T

E

E

A

A

V

C

M

M

S

A

A

V

I

L

R

R

L

I

A

M

R

R

G

A

Y

Y

T

T

G

G

R

R

D

D

K

K

I

I

I

I

K

K

F

F

E
|
E

G

G

C

C

Y
|
Y

H
|
H

G
|
G

H

H

S

A

D

D

S

M

L

F

L

L

V

V

K

K

A

A

G
|
G

S
|
S

G

G

A

V

L

A

T

T

F

L

G

G

Q

L

P

P

S

S

S

S

P

P

G

G

V

V

P

P

A

K

D

K

L

T

A

T

K

A

H

N

T

T

L

L

I

T

A

T

D
x
P

Y

Y

N

N

D

D

L

L

N

E

S

A

V

V

K

K

Q

A

L

L

F

F

I

A

N

E

N

N

K

P

N

G

Q

E

I

I

A

A

C

G

V

V

I

I

V

L

E
|
E

P

P

V

I

A

V

G

G

N
|
N

M

S

G

G

V

F

V

I

L

V

P

P

E

D

E

A

G

G

F

F

L

L

S

E

G

G

L

L

R

R

D

E

L

I

C

T

S

L

N

E

E

H

G

D

A

A

L

L

L

L

I

V

F

F

D
|
D

E

E

V

V

I
x
M

T

T

G

G

F

F

R

R

L

I

A

A

P

Y

G

G

G

G

A

V

Q

Q

E

E

Y

K

F

F

N

G

V

V

M

T

P

P

D

D

I

L

T

T

T

T

L

L

G

G

K
|
K

I

I

L

I

G

G

G

G

G

G

L

L

P

P

V

V

G

G

A

A

Y

Y

G

G

G

G

R

K

K

R

E

E

I

I

M

M

E

Q

K

L

I

V

S

A

P

P

L

A

G

G

P

P

V

M

Y

Y

Q

Q

A

A

G
|
G

T
|
T

L

L

S

S

G

G

N

N

P

P

L

L

A

A

M

M

A

T

A

A

G

G

I

I

A

K

N

T

L

L

N

E

K

L

L

L

N

R

E

Q

N

P

F

G

Y

T

Y

Y

E

E

-

Y

L

L

R

D

K

Q

K

I

S

T

Q

K

Y

R

L

L

W

S

N

D

G

G

F

L

K

L

N

A

N

I

C

A

R

Q

E

E

L

T

K

G

L

H

N

A

Y

A

A

C

F

G

N

G

E

Q

I

V

E

S

S

G

M

M

S

F

C

G

M

F

F

F

F

F

T

T

E

E

R

G

P

P

V

V

K

H

S
x
N

F

Y

K
x
E

D

D

A

A

L
x
K

T

K

S

S

D

D

T

L

K

Q

K

K

Y

F

A

S

A

R

F

F

F

H

H

R

G

G

M

M

L

L

K

E

K

Q

G

G

I

I

N

Y

L

L

A

A

P

P

S

S

Q

Q

F

F

E

E

A
|
A

M

G

F

F

V

T

S

S

A

L

A

A

H

H

T

T

N

E

K

E

D

D

L

I

D

D

A

A

T

T

I

L

K

A

A

A

H

A

Y

R

E

T

V

V

L

M

K

S

E

A

L

L

active site: V21 (= V16), Y144 (= Y139), D239 (= D234), M242 (≠ I237), K267 (= K262), A401 (= A395)
binding (4s)-4,5-diaminopentanoic acid: E141 (= E136), G156 (= G151), S157 (= S152), P182 (≠ D177), N368 (≠ S362), E370 (≠ K364), K373 (≠ L367)
binding 4'-deoxy-4'-aminopyridoxal-5'-phosphate: G117 (= G112), T118 (= T113), Y144 (= Y139), H145 (= H140), G146 (= G141), E206 (= E201), N211 (= N206), D239 (= D234), G298 (= G293), T299 (= T294)

5i92F Crystal structure of glutamate-1-semialdehyde 2,1- aminomutase (gsa) from pseudomonas aeruginosa
55% identity, 98% coverage: 2:413/422 of query aligns to 5:413/420 of 5i92F

query
sites
5i92F

K

E

N

T

L

L

F

F

E

N

E

N

S

A

K

Q

R

K

Y

H

I

I

P

P

G

G

G

G

V
|
V

N

N

S

S

P

P

V

V

R

R

A

A

F

F

G

K

S

S

V

V

G

G

G

G

E

T

P

P

I

L

F

F

I

F

D

K

R

H

G

A

K

E

G

G

S

A

K

Y

I

V

Y

L

D

D

V

E

D

D

G

D

K

K

E

R

Y

Y

I

V

D

D

Y

Y

V

V

C

G

S

S

W

W

G

G

P

P

L

M

I

I

H

L

G

G

H

H

A

S

D

H

D

P

D

D

I

V

I

L

T

D

E

A

V

V

E

R

R

R

V

Q

L

L

K

D

K

H

G

G

T

L

T

S

F

Y

G

G

A

A

P

P

T

T

V

A

L

L

E

E

L

V

E

E

L

M

A

A

K

D

K

L

V

V

V

C

E

S

M

M

V

V

P

P

S

S

I

M

E

E

M

M

V

V

R

R

M

M

V

V

S

S

S

S

G

G

T

T

E

E

A

A

V

T

M

M

S

S

A

A

I

I

R

R

L

L

A

A

R

R

G

G

Y

Y

T

T

G

G

R

R

D

D

K

S

I

I

I

I

K

K

F

F

E

E

G

G

C

C

Y
|
Y

H

H

G

G

H

H

S

S

D

D

S

S

L

L

L

L

V

V

K

K

A

A

G

G

S

S

G

-

A

-

L

-

T

T

F

F

G

G

Q

V

P

P

S

N

S

S

P

P

G

G

V

V

P

P

A

A

D

A

L

F

A

A

K

K

H

H

T

T

L

L

I

T

A

L

D

P

Y

F

N

N

D

D

L

I

N

E

S

A

V

V

K

R

Q

K

L

T

F

L

I

G

N

E

N

V

K

G

N

K

Q

E

I

V

A

A

C

C

V

I

I

I

V

V

E
|
E

P

P

V

V

A

A

G

G

N

N

M

M

G

N

V

C

V

V

L

P

P

P

E

A

E

P

G

G

F

F

L

L

S

E

G

G

L

L

R

R

D

E

L

A

C

C

S

D

N

E

E

H

G

G

A

V

L

V

L

L

I

I

F

F

D
|
D

E

E

V

V

I
x
M

T

T

G

G

F

F

R

R

L

V

A

A

P

L

G

G

G

G

A

A

Q

Q

E

A

Y

Y

F

Y

N

G

V

V

M

T

P

P

D

D

I

L

T

S

T

T

L

F

G

G

K
|
K

I

I

L

I

G

G

G

G

G

G

L

M

P

P

V

V

G

G

A

A

Y

F

G

G

G

G

R

K

K

R

E

E

I

I

M

M

E

Q

K

Q

I

I

S

S

P

P

L

L

G

G

P

P

V

V

Y

Y

Q

Q

A

A

G

G

T

T

L

-

S

-

G

G

N

N

P

P

L

L

A

A

M

M

A

A

A

A

G

G

I

L

A

T

N

T

L

L

N

R

K

L

L

I

N

S

E

R

-

P

N

G

F

F

Y

H

Y

D

E

E

L

L

R

T

K

A

K

Y

S

T

Q

T

Y

R

L

M

W

L

N

D

G

G

F

L

K

Q

N

Q

N

R

C

A

R

D

E

A

L

A

K

G

L

I

N

P

Y

F

A

V

F

T

N

T

E

Q

I

A

E

G

S

G

M

M

S

F

C

G

M

L

F

Y

F

F

T

S

-

G

E

A

R

D

P

A

V

I

K

V

S

T

F

F

K

E

D

D

A

V

L

M

T

A

S

S

D

D

T

V

K

E

K

R

Y

F

A

K

A

R

F

F

F

F

H

H

G

L

M

M

L

L

K

D

K

G

G

G

I

V

N

Y

L

L

A

A

P

P

S

S

Q

A

F

F

E

E

A
|
A

M

G

F

F

V

T

S

S

A

I

A

A

H

H

T

G

N

D

K

K

D

E

L

L

D

E

A

I

T

T

I

L

K

N

A

A

active site: V19 (= V16), Y142 (= Y139), E201 (= E201), D234 (= D234), M237 (≠ I237), K262 (= K262), A395 (= A395)

Sites not aligning to the query:

binding leucine: 417, 418, 420

2e7uA Crystal structure of glutamate-1-semialdehyde 2,1-aminomutase from thermus thermophilus hb8
55% identity, 98% coverage: 5:418/422 of query aligns to 10:424/424 of 2e7uA

query
sites
2e7uA

F

F

E

Q

E

E

S

A

K

K

R

R

Y

H

I

I

P

P

G

G

G

G

V
|
V

N

S

S

S

P

P

V

V

R

R

A

A

F

F

G

K

S

A

V

V

G

G

G

G

E

T

P

P

I

P

F

F

I

L

D

V

R

R

G

G

K

E

G

G

S

A

K

Y

I

V

Y

W

D

D

V

A

D

D

G

G

K

N

E

R

Y

Y

I

L

D

D

Y

Y

V

V

C

M

S

S

W

W

G

G

P

P

L

L

I

I

H

L

G

G

H

H

A

A

D

H

D

P

D

K

I

V

I

L

T

A

E

R

V

V

E

R

R

E

V

T

L

L

K

E

K

R

G

G

T

L

T

T

F

F

G

G

A

A

P

P

T

S

V

P

L

L

E

E

L

V

E

A

L

L

A

A

K

K

K

K

V

V

V

K

E

R

M

A

V

Y

P

P

S

F

I

V

E

D

M

L

V

V

R

R

M

F

V

V

S

N

S

S

G
|
G

T
|
T

E

E

A

A

V

T

M

M

S

S

A

A

I

L

R

R

L

L

A

A

R

R

G

G

Y

Y

T

T

G

G

R

R

D

P

K

Y

I

I

I

V

K

K

F

F

E

R

G

G

C

N

Y
|
Y

H
|
H

G

G

H

H

S

A

D

D

S

G

L

L

L

L

V

V

K

E

A

A

G

G

S

S

G

G

A

A

L

L

T

T

F

L

G

G

Q

V

P

P

S

S

S

S

P

A

G

G

V

V

P

P

A

E

D

E

L

Y

A

A

K

K

H

L

T

T

L

L

I

V

A

L

D

E

Y

Y

N

N

D

D

L

P

N

E

S

G

V

L

K

R

Q

E

L

V

F

L

I

K

N

R

N

R

K

G

N

E

Q

E

I

I

A

A

C

A

V

I

I

I

V

F

E
|
E

P

P

V

V

A

V

G

G

N
|
N

M

A

G

G

V

V

V

L

L

V

P

P

E

T

E

E

G

D

F

F

L

L

S

K

G

A

L

L

R

H

D

E

L

-

C

A

S

K

N

A

E

Y

G

G

A

V

L

L

L

L

I

I

F

A

D
|
D

E

E

V
|
V

I
x
M

T

T

G

G

F

F

R

R

L

L

A

A

P

F

G

G

G

G

A

A

Q

T

E

E

Y

L

F

L

N

G

V

L

M

K

P

P

D

D

I

L

T

V

T

T

L

L

G

G

K
|
K

I

I

L

L

G

G

G

G

G

G

L

L

P

P

V

A

G

A

A

A

Y

Y

G

A

G

G

R

R

K

R

E

E

I

I

M

M

E

E

K

K

I

V

S

A

P

P

L

L

G

G

P

P

V

V

Y

Y

Q

Q

A

A

G

G

T

T

L

L

S

S

G

G

N

N

P

P

L

L

A

A

M

M

A

A

A

A

G

G

I

L

A

A

N

T

L

L

N

E

K

L

L

L

N

E

E

E

N

N

-

P

-

G

F

Y

Y

Y

Y

A

E

Y

L

L

R

E

K

D

K

L

S

G

Q

A

Y

R

L

L

W

E

N

A

G

G

F

L

K

K

N

E

N

V

C

L

R

K

E

E

L

K

K

G

L

L

N

P

Y

H

A

T

F

V

N

N

E

R

I

V

E

G

S

S

M

M

S

I

C

T

M

V

F

F

F

F

T

T

E

E

R

G

P

P

V

V

K

V

S

T

F

F

K

Q

D

D

A

A

L

R

T

R

S

T

D

D

T

T

K

E

K

L

Y

F

A

K

A

R

F

F

F

F

H

H

G

G

M

L

L

L

K

D

K

R

G

G

I

I

N

Y

L

W

A

P

P

P

S

S

Q

N

F

F

E

E

A
|
A

M

A

F

F

V

L

S

S

A

V

A

A

H

H

T

R

N

E

K

E

D

D

L

V

D

E

A

K

T

T

I

L

K

E

A

A

H

L

Y

R

E

K

V

A

L

L

active site: V21 (= V16), Y144 (= Y139), E206 (= E201), D238 (= D234), M241 (≠ I237), K266 (= K262), A401 (= A395)
binding 4'-deoxy-4'-aminopyridoxal-5'-phosphate: G117 (= G112), T118 (= T113), Y144 (= Y139), H145 (= H140), N211 (= N206), D238 (= D234), V240 (= V236)

6w80A Crystal structure of glutamate-1-semialdehyde 2,1-aminomutase from stenotrophomonas maltophilia k279a in complex with plp
51% identity, 97% coverage: 4:411/422 of query aligns to 14:419/430 of 6w80A

query
sites
6w80A

L

L

F

F

E

S

E

R

S

A

K

Q

R

Q

Y

L

I

L

P

P

G

G

G

G

V
|
V

N

N

S

S

P

P

V

V

R

R

A

A

F

F

G

K

S

S

V

V

G

G

G

G

E

E

P

P

I

F

F

F

I

V

D

E

R

R

G

A

K

D

G

G

S

A

K

Y

I

L

Y

Y

D

D

V

V

D

D

G

G

K

N

E

R

Y

Y

I

I

D

D

Y

Y

V

V

C

G

S

S

W

W

G

G

P

P

L

M

I

I

H

V

G

G

H

H

A

N

D

H

D

P

D

A

I

V

I

R

T

Q

E

A

V

V

E

K

R

K

V

A

L

I

K

D

K

N

G

G

T

L

T

S

F

F

G

G

A

A

P

P

T

C

V

A

L

G

E

E

L

V

E

T

L

M

A

A

K

E

K

T

V

I

V

T

E

R

M

L

V

V

P

P

S

S

I

C

E

E

M

M

V

V

R

R

M

M

V

V

S

N

S
|
S

G
|
G

T
|
T

E

E

A

A

V

T

M

L

S

S

A

A

I

I

R

R

L

L

A

A

R

R

G

G

Y

A

T

T

G

G

R

R

D

N

K

R

I

I

I

V

K

K

F

F

E

E

G

G

C

C

Y
|
Y

H
|
H

G

G

H

H

S

G

D

D

S

S

L

F

L

L

V

V

K

K

A

A

G

-

S

-

G

-

A

M

L

L

T

T

F

L

G

G

Q

V

P

P

S

T

S

S

P

P

G

G

V

V

P

P

A

A

D

G

L

L

A

S

K

E

H

L

T

T

L

L

I

T

A

L

D

P

Y

Y

N

N

D

D

L

F

N

E

S

A

V

A

K

T

Q

A

L

L

F

F

I

E

N

Q

N

Q

K

G

N

D

Q

D

I

I

A

A

C

G

V

L

I

I

V

I

E
|
E

P

P

V

V

A

V

G

G

N
|
N

M

A

G

N

V

C

V

I

L

P

P

P

E

R

E

E

G

G

F

Y

L

L

S

Q

G

H

L

L

R

R

D

A

L

L

C

C

S

T

N

K

E

H

G

G

A

A

L

L

L

L

I

I

F

F

D
|
D

E

E

V
|
V

I

M

T

T

G

G

F

F

R

R

L

V

A

A

P

L

G

G

G

G

A

A

Q

Q

E

A

Y

H

F

Y

N

G

V

I

M

T

P

P

D

D

I

L

T

T

T

T

L

F

G

G

K
|
K

I

I

L

I

G

G

G

G

G

G

L

M

P

P

V

V

G

G

A

A

Y

Y

G

G

G

G

R

R

K

R

E

E

I

L

M

M

E

Q

K

Q

I

I

S

A

P

P

L

A

G

G

P

P

V

I

Y

Y

Q

Q

A

A

G

G

T

T

L

L

S

S

G

G

N

N

P

P

L

V

A

A

M

M

A

A

A

A

G

G

I

L

A

A

N

M

L

L

N

E

K

L

L

V

N

Q

E

Q

-

P

N

G

F

F

Y

H

Y

A

E

D

L

L

R

A

K

E

K

R

S

T

Q

A

Y

R

L

L

W

C

N

A

G

G

F

L

K

E

N

A

N

A

C

A

R

A

E

D

L

A

K

G

L

V

N

A

Y

V

A

T

F

T

N

T

E

R

I

V

E

G

S

A

M

M

S

F

C

G

M

L

F

F

F

F

T

T

E

S

R

E

P

K

V

V

K

E

S

T

F

Y

K

A

D

Q

A

A

L

T

T

A

S

C

D

D

T

I

K

P

K

A

Y

F

A

N

A

R

F

F

F

F

H

H

G

A

M

M

L

L

K

E

K

Q

G

G

I

V

N

F

L

L

A

A

P

P

S

S

Q

A

F

Y

E

E

A

A

M

G

F

F

V

L

S

S

A

S

A

A

H

H

T

D

N

D

K

A

D

V

L

I

D

E

A

A

T

T

I

L

active site: V26 (= V16), Y149 (= Y139), D241 (= D234), K269 (= K262)
binding pyridoxal-5'-phosphate: S121 (= S111), G122 (= G112), T123 (= T113), Y149 (= Y139), H150 (= H140), E208 (= E201), N213 (= N206), D241 (= D234), V243 (= V236), K269 (= K262)

3usfB Crystal structure of dava-4
51% identity, 99% coverage: 3:421/422 of query aligns to 8:402/402 of 3usfB

query
sites
3usfB

N

E

L

I

F

F

E

A

E

A

S

A

K

Q

R

K

Y

L

I

M

P

P

G

G

G

G

V
|
V

N

S

S

S

P

P

V

V

R

R

A

A

F

F

G

K

S

S

V

V

G

G

G

G

E

Q

P

P

I

I

F

V

I

F

D

D

R

R

G

V

K

K

G

D

S

A

K

Y

I

A

Y

W

D

D

V

V

D

D

G

G

K

N

E

R

Y

Y

I

I

D

D

Y

Y

V

V

C

G

S

T

W

W

G

G

P

P

L

A

I

I

H

C

G

G

H

H

A

A

D

H

D

P

D

E

I

V

I

I

T

E

E

A

V

L

E

K

R

V

V

A

L

M

K

E

K

K

G

G

T

T

T

S

F

F

G

G

A

A

P

P

T

C

V

A

L

L

E

E

L

N

E

V

L

L

A

A

K

E

K

M

V

V

V

N

E

D

M

A

V

V

P

P

S

S

I

I

E

E

M

M

V

V

R

R

M

F

V

V

S

N

S

S

G
|
G

T
|
T

E

E

A

A

V

C

M

M

S

A

A

V

I

L

R

R

L

I

A

M

R

R

G

A

Y

Y

T

T

G

G

R

R

D

D

K

K

I

I

I

I

K

K

F

F

E

E

G

G

C

C

Y
|
Y

H

H

G

G

H

H

S

A

D

D

S

T

L

-

L

-

V

-

K

-

A

-

G

-

S

-

G

-

A

-

L

-

T

-

F

-

G

-

Q

-

P

-

S

-

S

-

P

-

G

-

V

-

P

-

A

-

D

-

L

-

A

-

K

A

H

N

T

T

L

L

I

T

A

T

D

P

Y

Y

N

N

D

D

L

L

N

E

S

A

V

V

K

K

Q

A

L

L

F

F

I

A

N

E

N

N

K

P

N

G

Q

E

I

I

A

A

C

G

V

V

I

I

V

L

E
|
E

P

P

V

I

A

V

G

G

N
|
N

M

S

G

G

V

F

V

I

L

V

P

P

E

D

E

A

G

G

F

F

L

L

S

E

G

G

L

L

R

R

D

E

L

I

C

T

S

L

N

E

E

H

G

D

A

A

L

L

L

L

I

V

F

F

D
|
D

E

E

V
|
V

I
x
M

T

T

G

G

F

F

R

R

L

I

A

A

P

Y

G

G

G

G

A

V

Q

Q

E

E

Y

K

F

F

N

G

V

V

M

T

P

P

D

D

I

L

T

T

T

T

L

L

G

G

K
|
K

I

I

L

I

G

G

G

G

G

G

L

L

P

P

V

V

G

G

A

A

Y

Y

G

G

G

G

R

K

K

R

E

E

I

I

M

M

E

Q

K

L

I

V

S

A

P

P

L

A

G

G

P

P

V

M

Y

Y

Q

Q

A

A

G
|
G

T
|
T

L

L

S

S

G

G

N

N

P

P

L

L

A

A

M

M

A

T

A

A

G

G

I

I

A

K

N

T

L

L

N

E

K

L

L

L

N

R

E

Q

N

P

F

G

Y

T

Y

Y

E

E

-

Y

L

L

R

D

K

Q

K

I

S

T

Q

K

Y

R

L

L

W

S

N

D

G

G

F

L

K

L

N

A

N

I

C

A

R

Q

E

E

L

T

K

G

L

H

N

A

Y

A

A

C

F

G

N

G

E

Q

I

V

E

S

S

G

M

M

S

F

C

G

M

F

F

F

F

F

T

T

E

E

R

G

P

P

V

V

K

H

S

N

F

Y

K

E

D

D

A

A

L

K

T

K

S

S

D

D

T

L

K

Q

K

K

Y

F

A

S

A

R

F

F

F

H

H

R

G

G

M

M

L

L

K

E

K

Q

G

G

I

I

N

Y

L

L

A

A

P

P

S

S

Q

Q

F

F

E

E

A
|
A

M

G

F

F

V

T

S

S

A

L

A

A

H

H

T

T

N

E

K

E

D

D

L

I

D

D

A

A

T

T

I

L

K

A

A

A

H

A

Y

R

E

T

V

V

L

M

K

S

E

A

L

L

active site: V21 (= V16), Y144 (= Y139), E181 (= E201), D214 (= D234), M217 (≠ I237), K242 (= K262), A376 (= A395)
binding (4s)-4,5-diaminopentanoic acid: G273 (= G293), T274 (= T294)
binding (5-hydroxy-4,6-dimethylpyridin-3-yl)methyl dihydrogen phosphate: G117 (= G112), T118 (= T113), Y144 (= Y139), E181 (= E201), N186 (= N206), D214 (= D234), V216 (= V236), M217 (≠ I237), K242 (= K262)

2hp1B Inter-subunit signaling in gsam (see paper)
51% identity, 99% coverage: 3:421/422 of query aligns to 8:398/398 of 2hp1B

query
sites
2hp1B

N

E

L

I

F

F

E

A

E

A

S

A

K

Q

R

K

Y

L

I

M

P

P

G

G

G

G

V
|
V

N

S

S
|
S

P

P

V
|
V

R
|
R

A

A

F

F

G

K

S

S

V

V

G

G

G

G

E

Q

P

P

I

I

F

V

I

F

D

D

R

R

G

V

K

K

G

D

S

A

K

Y

I

A

Y

W

D

D

V

V

D

D

G

G

K

N

E

R

Y

Y

I

I

D

D

Y

Y

V

V

C

G

S

T

W
|
W

G

G

P

P

L

A

I

I

H

C

G

G

H

H

A

A

D

H

D

P

D

E

I

V

I

I

T

E

E

A

V

L

E

K

R

V

V

A

L

M

K

E

K

K

G

G

T

T

T

S

F

F

G

G

A

A

P

P

T

C

V

A

L

L

E

E

L

N

E

V

L

L

A

A

K

E

K

M

V

V

V

N

E

D

M

A

V

V

P

P

S

S

I

I

E

E

M

M

V

V

R

R

M

F

V

V

S

N

S
|
S

G
|
G

T
|
T

E

E

A

A

V

C

M

M

S

A

A

V

I

L

R

R

L

I

A

M

R

R

G

A

Y

Y

T

T

G

G

R

R

D

D

K

K

I

I

I

I

K

K

F

F

E

E

G

G

C

C

Y
|
Y

H

H

G

G

H

H

S

-

D

-

S

-

L

-

L

-

V

-

K

-

A

-

G

-

S

-

G

-

A

-

L

-

T

-

F

-

G

-

Q

-

P

-

S

-

S

-

P

-

G

-

V

-

P

-

A

-

D

-

L

-

A

-

K

-

H

N

T

T

L

L

I

T

A

T

D

P

Y

Y

N

N

D

D

L

L

N

E

S

A

V

V

K

K

Q

A

L

L

F

F

I

A

N

E

N

N

K

P

N

G

Q

E

I

I

A

A

C

G

V

V

I

I

V

L

E
|
E

P

P

V

I

A

V

G

G

N
|
N

M

S

G

G

V

F

V

I

L

V

P

P

E

D

E

A

G

G

F

F

L

L

S

E

G

G

L

L

R

R

D

E

L

I

C

T

S

L

N

E

E

H

G

D

A

A

L

L

L

L

I

V

F

F

D
|
D

E

E

V
|
V

I
x
M

T

T

G

G

F

F

R

R

L

I

A

A

P

Y

G

G

G

G

A

V

Q

Q

E

E

Y

K

F

F

N

G

V

V

M

T

P

P

D

D

I

L

T

T

T

T

L

L

G

G

K
|
K

I

I

L

I

G

G

G

G

G

G

L

L

P

P

V

V

G

G

A

A

Y

Y

G

G

G

G

R

K

K

R

E

E

I

I

M

M

E

Q

K

L

I

V

S

A

P

P

L

A

G

G

P

P

V

M

Y

Y

Q

Q

A

A

G
|
G

T
|
T

L

L

S

S

G

G

N

N

P

P

L

L

A

A

M

M

A

T

A

A

G

G

I

I

A

K

N

T

L

L

N

E

K

L

L

L

N

R

E

Q

N

P

F

G

Y

T

Y

Y

E

E

-

Y

L

L

R

D

K

Q

K

I

S

T

Q

K

Y

R

L

L

W

S

N

D

G

G

F

L

K

L

N

A

N

I

C

A

R

Q

E

E

L

T

K

G

L

H

N

A

Y

A

A

C

F

G

N

G

E

Q

I

V

E

S

S

G

M

M

S

F

C

G

M

F

F

F

F

F

T

T

E

E

R

G

P

P

V

V

K

H

S

N

F

Y

K

E

D

D

A

A

L

K

T

K

S

S

D

D

T

L

K

Q

K

K

Y

F

A

S

A

R

F

F

F

H

H

R

G

G

M

M

L

L

K

E

K

Q

G

G

I

I

N

Y

L

L

A

A

P

P

S

S

Q

Q

F

F

E

E

A
|
A

M

G

F

F

V

T

S

S

A

L

A

A

H

H

T

T

N

E

K

E

D

D

L

I

D

D

A

A

T

T

I

L

K

A

A

A

H

A

Y

R

E

T

V

V

L

M

K

S

E

A

L

L

active site: V21 (= V16), Y144 (= Y139), E177 (= E201), D210 (= D234), M213 (≠ I237), K238 (= K262), A372 (= A395)
binding (4s)-4-amino-5-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino]pentanoic acid: G269 (= G293), T270 (= T294)
binding (4s)-4,5-diaminopentanoic acid: S23 (= S18), V25 (= V20), R26 (= R21), W61 (= W56), Y144 (= Y139)
binding pyridoxal-5'-phosphate: S116 (= S111), G117 (= G112), T118 (= T113), Y144 (= Y139), E177 (= E201), N182 (= N206), D210 (= D234), V212 (= V236), M213 (≠ I237), K238 (= K262)

Query Sequence

>WP_013451594.1 NCBI__GCF_000183405.1:WP_013451594.1
MKNLFEESKRYIPGGVNSPVRAFGSVGGEPIFIDRGKGSKIYDVDGKEYIDYVCSWGPLI
HGHADDDIITEVERVLKKGTTFGAPTVLELELAKKVVEMVPSIEMVRMVSSGTEAVMSAI
RLARGYTGRDKIIKFEGCYHGHSDSLLVKAGSGALTFGQPSSPGVPADLAKHTLIADYND
LNSVKQLFINNKNQIACVIVEPVAGNMGVVLPEEGFLSGLRDLCSNEGALLIFDEVITGF
RLAPGGAQEYFNVMPDITTLGKILGGGLPVGAYGGRKEIMEKISPLGPVYQAGTLSGNPL
AMAAGIANLNKLNENFYYELRKKSQYLWNGFKNNCRELKLNYAFNEIESMSCMFFTERPV
KSFKDALTSDTKKYAAFFHGMLKKGINLAPSQFEAMFVSAAHTNKDLDATIKAHYEVLKE
LT

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory