SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing WP_013452051.1 NCBI__GCF_000183405.1:WP_013452051.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

P34047 Imidazoleglycerol-phosphate dehydratase 1, chloroplastic; IGPD 1; Protein HISTIDINE BIOSYNTHESIS 5A; EC 4.2.1.19 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
45% identity, 100% coverage: 1:194/194 of query aligns to 72:268/270 of P34047

query
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P34047

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H110 (= H39) binding Mn(2+)
H136 (= H65) binding Mn(2+)
H137 (= H66) binding Mn(2+)
E140 (= E69) binding Mn(2+)
H208 (≠ E137) binding Mn(2+)
H232 (= H161) binding Mn(2+)
H233 (= H162) binding Mn(2+)
E236 (= E165) binding Mn(2+)

O23346 Imidazoleglycerol-phosphate dehydratase 2, chloroplastic; IGPD 2; Protein HISTIDINE BIOSYNTHESIS 5B; EC 4.2.1.19 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
44% identity, 99% coverage: 2:194/194 of query aligns to 75:270/272 of O23346

query
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O23346

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E86 (= E13) binding substrate
H112 (= H39) binding Mn(2+)
112:120 (vs. 39:47, 56% identical) binding substrate
H138 (= H65) binding Mn(2+)
HHTNE 138:142 (≠ HHTFE 65:69) binding substrate
H139 (= H66) binding Mn(2+)
E142 (= E69) binding Mn(2+)
R164 (= R91) binding substrate
R186 (= R113) binding substrate
H210 (≠ E137) binding Mn(2+)
H234 (= H161) binding Mn(2+)
234:242 (vs. 161:169, 78% identical) binding substrate
H235 (= H162) binding Mn(2+)
E238 (= E165) binding Mn(2+)
SSK 264:266 (≠ STK 188:190) binding substrate

Sites not aligning to the query:

73 E→Q: Loss of activity.

Q9S5G5 Histidine biosynthesis bifunctional protein HisB; EC 3.1.3.15; EC 4.2.1.19 from Escherichia coli O157:H7 (see paper)
46% identity, 98% coverage: 3:193/194 of query aligns to 167:355/355 of Q9S5G5

query
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Q9S5G5

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Sites not aligning to the query:

1:166 Histidinol-phosphatase
9 binding Mg(2+)
11 binding Mg(2+)
17 E→A: Severe decrease in histidinol-phosphate phosphatase activity in presence of low magnesium concentration. At higher magnesium concentration (5mM), no effect on activity.
93 binding Zn(2+)
95 binding Zn(2+)
101 binding Zn(2+)
103 binding Zn(2+)
130 binding Mg(2+)

5el9A A. Thaliana igpd2 in complex with the triazole-phosphonate inhibitor, (s)-c348, to 1.1a resolution (see paper)
44% identity, 99% coverage: 2:194/194 of query aligns to 2:197/199 of 5el9A

query
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5el9A

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binding [(2S)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]phosphonic acid: R91 (= R91), R113 (= R113), S191 (= S188), K193 (= K190)

5ekwA A. Thaliana igpd2 in complex with the racemate of the triazole- phosphonate inhibitor, c348 (see paper)
44% identity, 97% coverage: 3:191/194 of query aligns to 3:194/194 of 5ekwA

query
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5ekwA

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binding [(2S)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]phosphonic acid: R91 (= R91), R113 (= R113), S191 (= S188), K193 (= K190)
binding [(2R)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]phosphonic acid: R91 (= R91), R113 (= R113), S191 (= S188), K193 (= K190)

2f1dA X-ray structure of imidazoleglycerol-phosphate dehydratase (see paper)
45% identity, 92% coverage: 2:180/194 of query aligns to 1:179/183 of 2f1dA

query
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2f1dA

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A

A

V

T

E

E

binding manganese (ii) ion: H38 (= H39), H64 (= H65), E68 (= E69), H136 (≠ E137), H160 (= H161), E164 (= E165)

6fwhL Acanthamoeba igpd in complex with r-c348 to 1.7a resolution (see paper)
45% identity, 99% coverage: 3:194/194 of query aligns to 2:195/195 of 6fwhL

query
sites
6fwhL

R

R

K

E

A

A

E
x
Q

I

V

I

A

R

R

V

E

T

T

N

G

E
|
E

T

T

E

K

I

I

K

E

L

V

S

R

L

L

S

S

L

L

D

D

E

G

D

T

K

G

E

V

I

S

L

D

I

V

S

K

T

T

G

G

C

I

G

G

F

F

L

L

D

D

H
|
H

M

M

L

L

N

S

L

A

F

L

A

A

K

K

H

H

G

G

D

R

I

F

G

D

L

L

K

Y

L

L

K

R

A

C

K

A

G

G

D

D

S

L

H

H

I

V

D

D

W

D

H
|
H

T

T

F

S

E
|
E

D

D

I

C

G

A

I

I

A

V

L

L

G

G

K

Q

G

A

F

F

Y

R

E
x
Q

A

A

L

I

G

G

D

E

K

R

K

K

G

G

I

I

V

K

R
|
R

Y

Y

G

G

F

S

F

A

L

Y

L

A

P

P

M

L

D

D

E

E

T

S

L

L

V

A

E

R

V

A

A

V

V

V

D

D

F

I

S

S

G

S

R
|
R

S

P

Y

F

L

A

N

V

Y

I

D

D

V

L

K

K

Y

L

Y

K

A

R

G

E

K

K

V

I

G

G

D

E

V

L

D

S

V

C

E

E

L

M

F

I

K

P

E
x
H

F

V

F

L

R

H

A

S

F

F

A

A

D

T

N

S

A

A

K

N

C

L

N

T

L

L

H

H

I

V

V

E

K

V

R

L

Y

Y

G

G

E

A

N

N

T

D

H
|
H

I

K

V

A

E
|
E

A

S

I

A

F

F

K

K

A

A

V

T

A

A

R

L

G

A

I

L

R

R

M

E

A

A

V

V

E

T

I

K

K

D

G

G

-

P

-

A

D

D

D

A

I

V

P

P

S
|
S

T

T

K
|
K

G

G

V

V

L

L

E

E

binding [(2R)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]phosphonic acid: E12 (= E13), H38 (= H39), H64 (= H65), H65 (= H66), E68 (= E69), R90 (= R91), R112 (= R113), H160 (= H161), H161 (= H162), E164 (= E165), S189 (= S188), K191 (= K190)
binding magnesium ion: Q5 (≠ E6), Q80 (≠ E81)
binding manganese (ii) ion: H38 (= H39), H64 (= H65), E68 (= E69), H136 (≠ E137), H160 (= H161), E164 (= E165)

6fwhA Acanthamoeba igpd in complex with r-c348 to 1.7a resolution (see paper)
45% identity, 99% coverage: 3:194/194 of query aligns to 3:196/196 of 6fwhA

query
sites
6fwhA

R

R

K

E

A

A

E

Q

I

V

I

A

R

R

V

E

T

T

N

G

E
|
E

T

T

E

K

I

I

K

E

L

V

S

R

L

L

S

S

L

L

D

D

E

G

D

T

K

G

E

V

I

S

L

D

I

V

S

K

T

T

G

G

C

I

G

G

F

F

L

L

D

D

H
|
H

M

M

L

L

N

S

L

A

F

L

A

A

K

K

H

H

G

G

D

R

I

F

G

D

L

L

K

Y

L

L

K

R

A

C

K

A

G

G

D

D

S

L

H

H

I

V

D

D

W

D

H
|
H

T

T

F

S

E
|
E

D

D

I

C

G

A

I

I

A

V

L

L

G

G

K

Q

G

A

F

F

Y

R

E

Q

A

A

L

I

G

G

D

E

K

R

K

K

G

G

I

I

V

K

R
|
R

Y

Y

G

G

F

S

F

A

L

Y

L

A

P

P

M

L

D

D

E

E

T

S

L

L

V

A

E

R

V

A

A

V

V

V

D

D

F

I

S

S

G

S

R
|
R

S

P

Y

F

L

A

N

V

Y

I

D

D

V

L

K

K

Y

L

Y

K

A

R

G

E

K

K

V

I

G

G

D

E

V

L

D

S

V

C

E

E

L

M

F

I

K

P

E
x
H

F

V

F

L

R

H

A

S

F

F

A

A

D

T

N

S

A

A

K

N

C

L

N

T

L

L

H

H

I

V

V

E

K

V

R

L

Y

Y

G

G

E

A

N

N

T

D

H
|
H

I

K

V

A

E
|
E

A

S

I

A

F

F

K

K

A

A

V

T

A

A

R

L

G

A

I

L

R

R

M

E

A

A

V

V

E

T

I

K

K

D

G

G

-

P

-

A

D

D

D

A

I

V

P

P

S
|
S

T

T

K
|
K

G

G

V

V

L

L

E

E

binding [(2R)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]phosphonic acid: E13 (= E13), H39 (= H39), H65 (= H65), H66 (= H66), E69 (= E69), R91 (= R91), R113 (= R113), H161 (= H161), H162 (= H162), E165 (= E165), S190 (= S188), K192 (= K190)
binding manganese (ii) ion: H39 (= H39), H65 (= H65), E69 (= E69), H137 (≠ E137), H161 (= H161), E165 (= E165)

8qavA Medicago truncatula hisn5 (igpd) in complex with mn and ig2 (see paper)
45% identity, 92% coverage: 2:180/194 of query aligns to 1:179/184 of 8qavA

query
sites
8qavA

G

A

R

R

K

I

A

G

E

E

I

M

I

K

R

R

V

V

T

T

N

K

E

E

T

T

E

N

I

V

K

S

L

V

S

K

L

I

S

N

L

L

D

D

E

G

D

T

K

G

E

V

I

A

L

D

I

N

S

S

T

S

G

G

C

I

G

P

F

F

L

L

D

D

H
|
H

M

M

L

L

N

D

L

Q

F

L

A

A

K

S

H

H

G

G

D

L

I

F

G

D

L

V

K

H

L

V

K

K

A

A

K

T

G

G

D

D

S

T

H

H

I

I

D

D

W

D

H
|
H

T

T

F

N

E
|
E

D

D

I

V

G

A

I

L

A

A

L

I

G

G

K

T

G

A

F

L

Y

L

E

Q

A

A

L

L

G

G

D

D

K

R

K

K

G

G

I

I

V

N

R

R

Y

F

G

G

F

N

F

F

L

S

L

A

P

P

M

L

D

D

E

E

T

A

L

L

V

V

E

H

V

V

A

S

V

L

D

D

F

L

S

S

G

G

R

R

S

P

Y

H

L

L

N

G

Y

Y

D

D

V

L

K

N

Y

I

Y

P

A

T

G

Q

K

R

V

V

G

G

D

K

V

Y

D

D

V

T

E

Q

L

L

F

V

K

E

E
x
H

F

F

R

Q

A

S

F

L

A

V

D

N

N

T

A

S

K

G

C

M

N

T

L

L

H

H

I

I

V

R

K

Q

R

F

Y

S

G

G

E

T

N

N

T

S

H
|
H

H

H

I

I

V

I

E
|
E

A

A

I

T

F

F

K

K

A

A

V

F

A

A

R

R

G

A

I

L

R

R

M

Q

A

A

V

T

E

E

binding (2S,3S)-2,3-dihydroxy-3-(1H-imidazol-5-yl)propyl dihydrogen phosphate: H64 (= H65), H65 (= H66)
binding manganese (ii) ion: H38 (= H39), H64 (= H65), E68 (= E69), H136 (≠ E137), H160 (= H161), E164 (= E165)

8qawA Medicago truncatula hisn5 (igpd) in complex with mn, imd, edo, fmt, gol and trs (see paper)
45% identity, 92% coverage: 2:180/194 of query aligns to 2:180/185 of 8qawA

query
sites
8qawA

G

A

R

R

K

I

A

G

E

E

I

M

I

K

R

R

V

V

T

T

N

K

E
|
E

T

T

E

N

I

V

K

S

L

V

S

K

L

I

S

N

L

L

D

D

E

G

D

T

K

G

E

V

I

A

L

D

I

N

S

S

T

S

G

G

C

I

G

P

F

F

L

L

D

D

H
|
H

M

M

L

L

N

D

L
x
Q

F

L

A

A

K

S

H
|
H

G

G

D

L

I

F

G

D

L

V

K

H

L

V

K

K

A

A

K

T

G

G

D

D

S

T

H

H

I

I

D

D

W

D

H
|
H

T

T

F

N

E
|
E

D

D

I

V

G

A

I

L

A

A

L

I

G

G

K

T

G

A

F

L

Y

L

E

Q

A

A

L

L

G

G

D

D

K

R

K

K

G

G

I

I

V

N

R

R

Y

F

G

G

F

N

F

F

L

S

L

A

P

P

M

L

D

D

E

E

T

A

L

L

V

V

E

H

V

V

A

S

V

L

D

D

F

L

S

S

G

G

R

R

S

P

Y

H

L

L

N

G

Y

Y

D

D

V

L

K

N

Y

I

Y

P

A

T

G

Q

K

R

V

V

G

G

D

K

V

Y

D

D

V

T

E

Q

L

L

F

V

K

E

E
x
H

F

F

R

Q

A

S

F

L

A

V

D

N

N

T

A

S

K

G

C

M

N

T

L

L

H

H

I

I

V

R

K

Q

R

F

Y

S

G

G

E

T

N

N

T

S

H
|
H

H

H

I

I

V

I

E
|
E

A

A

I

T

F

F

K
|
K

A

A

V

F

A

A

R

R

G

A

I

L

R

R

M

Q

A

A

V

T

E

E

binding glycerol: Q43 (≠ L43), H47 (= H47), K169 (= K169)
binding imidazole: E13 (= E13), H66 (= H66), E69 (= E69)
binding manganese (ii) ion: H39 (= H39), H65 (= H65), E69 (= E69), H137 (≠ E137), H161 (= H161), E165 (= E165)

4qnkA The structure of wt a. Thaliana igpd2 in complex with mn2+ and phosphate (see paper)
44% identity, 92% coverage: 2:180/194 of query aligns to 2:180/185 of 4qnkA

query
sites
4qnkA

G

A

R

R

K

I

A

G

E

E

I

V

I

K

R

R

V

E

T

T

N

K

E

E

T

T

E

N

I

V

K

S

L

V

S

K

L

I

S

N

L

L

D

D

E

G

D

H

K

G

E

V

I

S

L

D

I

S

S

S

T

T

G

G

C

I

G

P

F

F

L

L

D

D

H
|
H

M

M

L

L

N

D

L
x
Q

F

L

A

A

K

S

H
|
H

G

G

D

L

I

F

G

D

L

V

K

H

L

V

K

R

A

A

K

T

G

G

D

D

S

T

H

H

I

I

D

D

W

D

H
|
H

H

H

T

T

F

N

E
|
E

D

D

I

V

G

A

I

L

A

A

L

I

G

G

K

T

G

A

F

L

Y

L

E

K

A

A

L

L

G

G

D

E

K

R

K

K

G

G

I

I

V

N

R

R

Y

F

G

G

F

D

F

F

L

T

L

A

P

P

M

L

D

D

E

E

T

A

L

L

V

I

E

H

V

V

A

S

V

L

D

D

F

L

S

S

G

G

R

R

S

P

Y

Y

L

L

N

G

Y

Y

D

N

V

L

K

E

Y

I

Y

P

A

T

G

Q

K

R

V

V

G

G

D

T

V

Y

D

D

V

T

E

Q

L

L

F

V

K

E

E
x
H

F

F

R

Q

A

S

F

L

A

V

D

N

N

T

A

S

K

G

C

M

N

T

L

L

H

H

I

I

V

R

K

Q

R

L

Y

A

G

G

E

K

N

N

T

S

H
|
H

H

H

I

I

V

I

E
|
E

A

A

I

T

F

F

K
|
K

A

A

V

F

A

A

R

R

G

A

I

L

R

R

M

Q

A

A

V

T

E

E

binding manganese (ii) ion: H39 (= H39), H65 (= H65), E69 (= E69), H137 (≠ E137), H161 (= H161), E165 (= E165)
binding phosphate ion: Q43 (≠ L43), H47 (= H47), K169 (= K169)

4mu1A The structure of wt a. Thaliana igpd2 in complex with mn2+, imidazole, and sulfate at 1.5 a resolution (see paper)
44% identity, 92% coverage: 2:180/194 of query aligns to 2:180/185 of 4mu1A

query
sites
4mu1A

G

A

R

R

K

I

A

G

E

E

I

V

I

K

R

R

V

E

T

T

N

K

E

E

T

T

E

N

I

V

K

S

L

V

S

K

L

I

S

N

L

L

D

D

E

G

D

H

K

G

E

V

I

S

L

D

I

S

S

S

T

T

G

G

C

I

G

P

F

F

L

L

D

D

H

H

M

M

L

L

N

D

L

Q

F

L

A

A

K

S

H

H

G

G

D

L

I

F

G

D

L

V

K

H

L

V

K

R

A

A

K

T

G

G

D

D

S

T

H

H

I

I

D

D

W

D

H
|
H

H

H

T

T

F

N

E
|
E

D

D

I

V

G

A

I

L

A

A

L

I

G

G

K

T

G

A

F

L

Y

L

E

K

A

A

L

L

G

G

D

E

K

R

K

K

G

G

I

I

V

N

R

R

Y

F

G

G

F

D

F

F

L

T

L

A

P

P

M

L

D

D

E

E

T

A

L

L

V

I

E

H

V

V

A

S

V

L

D

D

F

L

S

S

G

G

R

R

S

P

Y

Y

L

L

N

G

Y

Y

D

N

V

L

K

E

Y

I

Y

P

A

T

G

Q

K

R

V

V

G

G

D

T

V

Y

D

D

V

T

E

Q

L

L

F

V

K

E

E
x
H

F

F

R

Q

A

S

F

L

A

V

D

N

N

T

A

S

K

G

C

M

N

T

L

L

H

H

I

I

V

R

K

Q

R

L

Y

A

G

G

E

K

N

N

T

S

H

H

I

I

V

I

E

E

A

A

I

T

F

F

K

K

A

A

V

F

A

A

R

R

G

A

I

L

R

R

M

Q

A

A

V

T

E

E

binding imidazole: H65 (= H65), E69 (= E69)
binding manganese (ii) ion: H65 (= H65), E69 (= E69), H137 (≠ E137)

4mu0A The structure of wt a. Thaliana igpd2 in complex with mn2+ and 1,2,4- triazole at 1.3 a resolution (see paper)
44% identity, 92% coverage: 2:180/194 of query aligns to 2:180/185 of 4mu0A

query
sites
4mu0A

G

A

R

R

K

I

A

G

E

E

I

V

I

K

R

R

V

E

T

T

N

K

E

E

T

T

E

N

I

V

K

S

L

V

S

K

L

I

S

N

L

L

D

D

E

G

D

H

K

G

E

V

I

S

L

D

I

S

S

S

T

T

G

G

C

I

G

P

F

F

L

L

D

D

H

H

M

M

L

L

N

D

L

Q

F

L

A

A

K

S

H

H

G

G

D

L

I

F

G

D

L

V

K

H

L

V

K

R

A

A

K

T

G

G

D

D

S

T

H

H

I

I

D

D

W

D

H
|
H

T

T

F

N

E
|
E

D

D

I

V

G

A

I

L

A

A

L

I

G

G

K

T

G

A

F

L

Y

L

E

K

A

A

L

L

G

G

D

E

K

R

K

K

G

G

I

I

V

N

R

R

Y

F

G

G

F

D

F

F

L

T

L

A

P

P

M

L

D

D

E

E

T

A

L

L

V

I

E

H

V

V

A

S

V

L

D

D

F

L

S

S

G

G

R

R

S

P

Y

Y

L

L

N

G

Y

Y

D

N

V

L

K

E

Y

I

Y

P

A

T

G

Q

K

R

V

V

G

G

D

T

V

Y

D

D

V

T

E

Q

L

L

F

V

K

E

E
x
H

F

F

R

Q

A

S

F

L

A

V

D

N

N

T

A

S

K

G

C

M

N

T

L

L

H

H

I

I

V

R

K

Q

R

L

Y

A

G

G

E

K

N

N

T

S

H

H

I

I

V

I

E

E

A

A

I

T

F

F

K

K

A

A

V

F

A

A

R

R

G

A

I

L

R

R

M

Q

A

A

V

T

E

E

binding manganese (ii) ion: H65 (= H65), E69 (= E69), H137 (≠ E137)
binding 1,2,4-triazole: H65 (= H65), H66 (= H66)

4mu3A The form a structure of an e21q catalytic mutant of a. Thaliana igpd2 in complex with mn2+ and a mixture of its substrate, 2r3s-igp, and an inhibitor, 2s3s-igp, to 1.12 a resolution (see paper)
43% identity, 92% coverage: 2:180/194 of query aligns to 2:180/186 of 4mu3A

query
sites
4mu3A

G

A

R

R

K

I

A

G

E

E

I

V

I

K

R

R

V

E

T

T

N

K

E
x
Q

T

T

E

N

I

V

K

S

L

V

S

K

L

I

S

N

L

L

D

D

E

G

D

H

K

G

E

V

I

S

L

D

I

S

S

S

T

T

G

G

C

I

G

P

F

F

L

L

D

D

H

H

M

M

L

L

N

D

L

Q

F

L

A

A

K

S

H

H

G

G

D

L

I

F

G

D

L

V

K

H

L

V

K

R

A

A

K

T

G

G

D

D

S

T

H

H

I

I

D

D

W

D

H
|
H

T

T

F

N

E
|
E

D

D

I

V

G

A

I

L

A

A

L

I

G

G

K

T

G

A

F

L

Y

L

E

K

A

A

L

L

G

G

D

E

K

R

K

K

G

G

I

I

V

N

R

R

Y

F

G

G

F

D

F

F

L

T

L

A

P

P

M

L

D

D

E

E

T

A

L

L

V

I

E

H

V

V

A

S

V

L

D

D

F

L

S

S

G

G

R

R

S

P

Y

Y

L

L

N

G

Y

Y

D

N

V

L

K

E

Y

I

Y

P

A

T

G

Q

K

R

V

V

G

G

D

T

V

Y

D

D

V

T

E

Q

L

L

F

V

K

E

E
x
H

F

F

R

Q

A

S

F

L

A

V

D

N

N

T

A

S

K

G

C

M

N

T

L

L

H

H

I

I

V

R

K

Q

R

L

Y

A

G

G

E

K

N

N

T

S

H

H

I

I

V

I

E

E

A

A

I

T

F

F

K

K

A

A

V

F

A

A

R

R

G

A

I

L

R

R

M

Q

A

A

V

T

E

E

binding (2S,3S)-2,3-dihydroxy-3-(1H-imidazol-5-yl)propyl dihydrogen phosphate: H65 (= H65), H66 (= H66)
binding (2R,3S)-2,3-dihydroxy-3-(1H-imidazol-5-yl)propyl dihydrogen phosphate: Q13 (≠ E13), H65 (= H65), H66 (= H66)
binding manganese (ii) ion: H65 (= H65), E69 (= E69), H137 (≠ E137)

6ezmU Imidazoleglycerol-phosphate dehydratase from saccharomyces cerevisiae (see paper)
41% identity, 98% coverage: 3:193/194 of query aligns to 2:212/212 of 6ezmU

query
sites
6ezmU

R

Q

K

K

A

A

E

L

I

V

I

K

R

R

V

I

T

T

N

N

E

E

T

T

E

K

I

I

K

Q

L

I

S

A

L

I

S

S

L

L

-

K

-

G

-

P

-

L

-

A

-

I

-

E

-

H

-

S

-

I

-

F

-

P

-

E

-

K

-

A

-

E

-

Q

-

A

D

T

E

Q

D

S

K

Q

E

V

I

I

L

N

I

V

S

H

T

T

G

G

C

I

G

G

F

F

L

L

D

D

H
|
H

M

M

L

I

N

H

L

A

F

L

A

A

K

K

H

H

G

S

D

G

I

W

G

S

L

L

K

I

L

V

K

E

A

C

K

I

G

G

D

D

S

L

H

H

I

I

D

D

W

D

H
|
H

T

T

F

T

E
|
E

D

D

I

C

G

G

I

I

A

A

L

L

G

G

K

Q

G

A

F

F

Y

K

E

E

A

A

L

L

G

G

D

A

K

V

K

R

G

G

I

V

V

K

R

R

Y

F

G

G

F

S

F

G

L

F

L

A

P

P

M

L

D

D

E

E

T

A

L

L

V

S

E

R

V

A

A

V

V

V

D

D

F

L

S

S

G

N

R

R

S

P

Y

Y

L

A

N

V

Y

V

D

E

V

L

K

G

Y

L

Y

Q

A

R

G

E

K

K

V

V

G

G

D

D

V

L

D

S

V

C

E

E

L

M

F

I

K

P

E
x
H

F

F

F

L

R

E

A

S

F

F

A

A

D

E

N

A

A

S

K

R

C

I

N

T

L

L

H

H

I

V

V

D

K

C

R

L

Y

R

G

G

E

K

N

N

T

D

H
|
H

I

R

V

S

E
|
E

A

S

I

A

F

F

K
|
K

A

A

V

L

A

A

R

V

G

A

I

I

R

R

M

E

A

A

V

T

E

S

I

P

K

N

G

G

-

T

D

N

D

D

I

V

P

P

S
|
S

T

T

K
|
K

G

G

V

V

L

L

binding [(2R)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]phosphonic acid: H57 (= H39), H83 (= H65), H84 (= H66), E87 (= E69), H179 (= H161), H180 (= H162), E183 (= E165), K187 (= K169), S207 (= S188), K209 (= K190)
binding manganese (ii) ion: H57 (= H39), H83 (= H65), E87 (= E69), H155 (≠ E137), H179 (= H161), E183 (= E165)

P06633 Imidazoleglycerol-phosphate dehydratase; IGPD; EC 4.2.1.19 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
40% identity, 98% coverage: 3:193/194 of query aligns to 4:219/220 of P06633

query
sites
P06633

R

Q

K

K

A

A

E

L

I

V

I

K

R

R

V

I

T

T

N

N

E

E

T

T

E

K

I

I

K

Q

L

I

S

A

L

I

S

S

L

L

-

K

-

G

-

P

-

L

-

A

-

I

-

E

-

H

-

S

-

I

-

F

-

P

-

E

-

K

-

E

-

A

-

E

-

A

-

V

-

A

-

E

-

Q

-

A

D

T

E

Q

D

S

K

Q

E

V

I

I

L

N

I

V

S

H

T

T

G

G

C

I

G

G

F

F

L

L

D

D

H
|
H

M
|
M

L
x
I

N
x
H

L
x
A

F
x
L

A
|
A

K
|
K

H
|
H

G

S

D

G

I

W

G

S

L

L

K

I

L

V

K

E

A

C

K

I

G

G

D

D

S

L

H

H

I

I

D

D

W

D

H
|
H

T
|
T

F
x
T

E
|
E

D

D

I

C

G

G

I

I

A

A

L

L

G

G

K

Q

G

A

F

F

Y

K

E

E

A

A

L

L

G

G

D

A

K

V

K

R

G

G

I

V

V

K

R
|
R

Y

F

G

G

F

S

F

G

L

F

L

A

P

P

M

L

D

D

E

E

T

A

L

L

V

S

E

R

V

A

A

V

V

V

D

D

F

L

S

S

G

N

R

R

S

P

Y

Y

L

A

N

V

Y

V

D

E

V

L

K

G

Y

L

Y

Q

A

R

G

E

K

K

V

V

G

G

D

D

V

L

D

S

V

C

E

E

L

M

F

I

K

P

E
x
H

F

F

F

L

R

E

A

S

F

F

A

A

D

E

N

A

A

S

K

R

C

I

N

T

L

L

H

H

I

V

V

D

K

C

R

L

Y

R

G

G

E

K

N

N

T

D

H
|
H

I
x
R

V
x
S

E
|
E

A
x
S

I
x
A

F
|
F

K
|
K

A

A

V

L

A

A

R

V

G

A

I

I

R

R

M

E

A

A

V

T

E

S

I

P

K

N

G

G

-

T

D

N

D

D

I

V

P

P

S
|
S

T
|
T

K
|
K

G

G

V

V

L

L

H64 (= H39) binding Mn(2+)
64:72 (vs. 39:47, 56% identical) binding substrate
H90 (= H65) binding Mn(2+)
HHTTE 90:94 (≠ HHTFE 65:69) binding substrate
H91 (= H66) binding Mn(2+)
E94 (= E69) binding Mn(2+)
R116 (= R91) binding substrate
H162 (≠ E137) binding Mn(2+)
H186 (= H161) binding Mn(2+)
186:194 (vs. 161:169, 56% identical) binding substrate
H187 (= H162) binding Mn(2+)
E190 (= E165) binding Mn(2+)
STK 214:216 (= STK 188:190) binding substrate

1rhyB Crystal structure of imidazole glycerol phosphate dehydratase (see paper)
43% identity, 92% coverage: 3:180/194 of query aligns to 3:178/180 of 1rhyB

query
sites
1rhyB

R

R

K

I

A

A

E

S

I

V

I

E

R

R

V

T

T

T

N

S

E

E

T

T

E

H

I

I

K

S

L

C

S

T

L

I

S

D

L

L

D

D

E

H

-

I

-

P

-

G

-

V

-

T

D

E

K

Q

E

K

I

I

L

N

I

V

S

S

T

T

G

G

C

I

G

G

F

F

L

L

D

D

H

H

M

M

L

F

N

T

L

A

F

L

A

A

K

K

H

H

G

G

D

G

I

M

G

S

L

L

K

Q

L

L

K

Q

A

C

K

K

G

G

D

D

S

-

H

-

I

-

D

-

W

-

H

-

T

T

F

A

E

E

D

D

I

C

G

A

I

L

A

A

L

L

G

G

K

E

G

A

F

F

Y

K

E

K

A

A

L

L

G

G

D

E

K

R

K

K

G

G

I

I

V

K

R

R

Y

Y

G

G

F

Y

F

A

L

Y

L

A

P

P

M

L

D

D

E

E

T

S

L

L

V

S

E

R

V

A

A

V

V

I

D

D

F

I

S

S

G

S

R

R

S

P

Y

Y

L

F

N

M

Y

C

D

H

V

L

K

P

Y

F

Y

T

A

R

G

E

K

K

V

V

G
|
G

D

D

V

L

D

S

V

T

E

E

L

M

F

V

K

S

E

H

F

L

R

Q

A

S

F

F

A

A

D

F

N

A

A

A

K

G

C

V

N

T

L

L

H

H

I

I

V

D

K

S

R

I

Y

R

G

G

E

E

N

N

T

N

H
|
H

H

H

I

I

V

A

E

E

A

S

I

A

F

F

K

K

A

A

V

L

A

A

R

L

G

A

I

I

R

R

M

M

A

A

V

I

E

S

binding glycerol: G126 (= G128), H159 (= H161)

P9WML9 Imidazoleglycerol-phosphate dehydratase; IGPD; EC 4.2.1.19 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
42% identity, 93% coverage: 13:193/194 of query aligns to 21:210/210 of P9WML9

query
sites
P9WML9

E

E

T

S

E

D

I

I

K

V

L

I

S

E

L

L

S

D

L

L

D

D

E

G

D

T

K

G

E

Q

I

V

L

A

I

V

S

D

T

T

G

G

C

V

G

P

F

F

L

Y

D

D

H
|
H

M
|
M

L
|
L

N
x
T

L
x
A

F
x
L

A
x
G

K
x
S

H
|
H

G

A

D

S

I

F

G

D

L

L

K

T

L

V

K

R

A

A

K

T

G

G

D

D

S

V

H

E

I

I

D

E

W

A

H
|
H

T
|
T

F
x
I

E
|
E

D

D

I

T

G

A

I

I

A

A

L

L

G

G

K

T

G

A

F

L

Y

G

E

Q

A

A

L

L

G

G

D

D

K

K

K

R

G

G

I

I

V

R

R

R

Y

F

G

G

F

D

F

A

L

F

L

I

P

P

M

M

D

D

E

E

T

T

L

L

V

A

E

H

V

A

A

A

V

V

D

D

F

L

S

S

G

G

R

R

S

P

Y

Y

L

C

-

V

-

H

-

T

-

G

-

E

-

P

-

D

N

H

Y

L

D

Q

V

H

K

T

Y

T

Y

I

A

A

G

G

K

S

V

S

G

V

D

P

V

Y

D

H

V

T

E

V

L

I

F

N

K

R

E
x
H

F

V

F

F

R

E

A

S

F

L

A

A

D

A

N

N

A

A

K

R

C

I

N

A

L

L

H

H

I

V

V

R

K

V

R

L

Y

Y

G

G

E

R

N

D

T

P

H
|
H

I
|
I

V
x
T

E
|
E

A
|
A

I
x
Q

F
x
Y

K
|
K

A

A

V

V

A

A

R

R

G

A

I

L

R

R

M

Q

A

A

V

V

E

E

-

P

-

D

I

P

K

R

G

V

D

S

D

G

I

V

P

P

S

S

T

T

K

K

G

G

V

A

L

L

H47 (= H39) binding Mn(2+)
47:55 (vs. 39:47, 44% identical) binding substrate
H73 (= H65) binding Mn(2+)
HHTIE 73:77 (≠ HHTFE 65:69) binding substrate
H74 (= H66) binding Mn(2+)
E77 (= E69) binding Mn(2+)
H152 (≠ E137) binding Mn(2+)
H176 (= H161) binding Mn(2+)
176:184 (vs. 161:169, 67% identical) binding substrate
H177 (= H162) binding Mn(2+)
E180 (= E165) binding Mn(2+)

2ae8B Crystal structure of imidazoleglycerol-phosphate dehydratase from staphylococcus aureus subsp. Aureus n315
47% identity, 84% coverage: 17:179/194 of query aligns to 10:169/172 of 2ae8B

query
sites
2ae8B

K

Q

L

L

S

N

L

I

S

S

L

I

D

S

E

D

D

D

K

Q

E

S

I

P

L

S

-

H

I

I

S

N

T

T

G

G

C

V

G

G

F

F

L

L

D

N

H
|
H

M

M

L

L

N

T

L

L

F

F

A

T

K

F

H

H

G

S

D

G

I

L

G

S

L

L

K

N

L

I

K

E

A

A

K

Q

G

G

D

D

S

D

H
|
H

I

-

D

-

W

-

H

-

H

H

T

V

F

T

E
|
E

D

D

I

I

G

G

I

I

A

V

L

I

G

G

K

Q

G

L

F

L

Y

L

E

E

A

M

L

I

G

K

D

D

K

K

G

H

I

F

V

V

R

R

Y

Y

G

G

F

T

F

M

L

Y

L

I

P

P

M

M

D

D

E

E

T

T

L

L

V

A

E

R

V

V

A

V

V

V

D

D

F

I

S

S

G

G

R

R

S

P

Y

Y

L

L

N

S

Y

F

D

N

V

A

K

S

Y

L

Y

S

A

K

G

E

K

K

V

V

G

G

D

T

V

F

D

D

V

T

E

E

L

L

F

V

K

E

E

E

F

F

R

R

A

A

F

V

A

V

D

I

N

N

A

A

K

R

C

L

N

T

L

T

H

H

I

I

V

D

K

L

R

I

Y

R

G

G

E

G

N

N

T

T

H
|
H

H

H

I

E

V

I

E
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E

A

A

I

I

F

F

K

K

A

A

V

F

A

S

R

R

G

A

I

L

R

G

M

I

A

A

V

L

binding magnesium ion: H33 (= H39), H55 (= H61), E59 (= E69), H151 (= H161), E155 (= E165)

P40374 Imidazoleglycerol-phosphate dehydratase; IGPD; EC 4.2.1.19 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
38% identity, 98% coverage: 3:193/194 of query aligns to 2:216/216 of P40374

query
sites
P40374

R

R

K

R

A

A

E

F

I

V

I

E

R

R

V

N

T

T

N

N

E

E

T

T

E

K

I

I

K

S

L

V

S

A

L

I

S

A

L

L

D

D

E

K

-

A

-

P

-

L

-

P

-

E

-

S

-

N

-

F

-

I

-

D

-

E

-

L

-

I

-

T

-

S

-

K

-

H

-

A

-

N

-

Q

-

K

-

G

D

E

K

Q

E

V

I

I

L

Q

I

V

S

D

T

T

G

G

C

I

G

G

F

F

L

L

D

D

H

H

M

M

L

Y

N

H

L

A

F

L

A

A

K

K

H

H

G

A

D

G

I

W

G

S

L

L

K

R

L

L

K

Y

A

S

K

R

G

G

D

D

S

L

H

I

I

I

D

D

W

D

H

H

T

T

F

A

E

E

D

D

I

T

G

A

I

I

A

A

L

L

G

G

K

I

G

A

F

F

Y

K

E

Q

A

A

L

M

G

G

D

N

K

F

K

A

G

G

I

V

V

K

R

R

Y

F

G

G

F

H

F

A

L

Y

L

C

P

P

M

L

D

D

E

E

T

A

L

L

V

S

E

R

V

S

A

V

V

V

D

D

F

L

S

S

G

G

R

R

S

P

Y

Y

L

A

N

V

Y

I

D

D

V

L

K

G

Y

L

Y

K

A

R

G

E

K

K

V

V

G

G

D

E

V

L

D

S

V

C

E

E

L

M

F

I

K

P

E

H

F

L

R

Y

A

S

F

F

A

S

D

V

N

A

A

A

K

G

C

I

N

T

L

L

H

H

I

V

V

T

K

C

R

L

Y

Y

G

G

E

S

N

N

T

D

H

H

I

R

V

A

E

E

A

S

I

A

F

F

K

K

A

S

V

L

A

A

R

V

G

A

I

M

R

R

M

A

A

A

V

T

E

S

I

L

K

T

G

G

-

S

D

S

D

E

I

V

P

P

S
|
S

T

T

K

K

G

G

V

V

L

L

S211 (= S188) modified: Phosphoserine

Query Sequence

>WP_013452051.1 NCBI__GCF_000183405.1:WP_013452051.1
MGRKAEIIRVTNETEIKLSLSLDEDKEILISTGCGFLDHMLNLFAKHGDIGLKLKAKGDS
HIDWHHTFEDIGIALGKGFYEALGDKKGIVRYGFFLLPMDETLVEVAVDFSGRSYLNYDV
KYYAGKVGDVDVELFKEFFRAFADNAKCNLHIVKRYGENTHHIVEAIFKAVARGIRMAVE
IKGDDIPSTKGVLE

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory