SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing WP_013460463.1 NCBI__GCF_000183725.1:WP_013460463.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

O66442 Acetylornithine aminotransferase; ACOAT; EC 2.6.1.11 from Aquifex aeolicus (strain VF5)
44% identity, 98% coverage: 7:388/391 of query aligns to 2:376/376 of O66442

query
sites
O66442

N

T

Y

Y

V

L

L

M

P

N

T

N

Y

Y

A

A

R

R

Q

L

N

P

I

V

N

K

F

F

V

V

A

R

G

G

K

K

N

G

A

V

V

Y

L

L

I

Y

D

D

S

E

E

E

G

G

K

K

E

E

Y

Y

I

L

D

D

F

F

A

V

A

S

G

G

I

I

A

G

V

V

C

N

S

S

V

L

G

G

H

H

A

A

N

Y

E

P

R

K

L

L

T

T

K

E

A

A

I

L

C

K

D

E

Q

Q

V

V

S

E

K

K

V

L

I

L

H

H

V

V

S

S

N

N

L

L

Y

Y

Y

E

I

N

E

P

P

W

Q

Q

A

E

E

E

C

L

A

A

R

H

R

K

I

L

V

V

E

K

M

H

S

F

G

W

Y

T

D

E

M

G

K

K

C

V

F

F

F

F

G

A

N

N

S

S

G
|
G

A
x
T

E

E

A

S

N

V

E

E

G

A

A

A

I

I

K

K

I

L

A

A

R

R

K

K

Y

Y

G

W

E

R

V

D

D

K

G

G

Q

K

P

N

K

K

R

-

Y

W

K

K

I

F

I

I

T

S

L

F

D

E

H

N

S

S

F

F

H

H

G

G

R

R

T

T

I

Y

T

G

A

S

L

L

K

S

A

A

T

T

G

G

Q

Q

E

P

S

K

M

F

H

H

N

K

Y

G

F

F

G

E

P

P

F

L

P

V

D

P

G

G

F

F

V

S

Y

Y

A

A

K

K

-

L

-

N

N

D

I

I

D

D

E

S

I

V

E

Y

S

K

L

L

I

L

D

D

E

E

H

E

T

T

V

A

A

G

V

I

M

I

I

I

E

E

L

V

V

I

Q

Q

G

G

E

E

G

G

G

G

V

V

Q

N

P

E

Q

A

D

S

R

E

A

D

K

F

V

L

Q

S

A

K

L

L

S

Q

A

E

M

I

L

C

K

K

S

E

R

K

D

D

V

V

L

L

L

L

M

I

V

I

D

D

E

E

V

V

Q

Q

T

T

G

G

I

I

Y

G

R

R

T

T

G

G

E

E

F

F

L

Y

A

A

S

Y

N

Q

L

H

Y

F

G

N

I

L

E

K

P

P

D

D

V

V

I

I

T

A

L

L

A

A

K
|
K

G

G

L

L

G

G

G

G

G

G

V

V

P

P

I

I

G

G

V

A

V

I

M

L

T

A

G

R

K

E

K

E

-

V

-

A

D

Q

I

S

F

F

S

T

P

P

G

G

D

S

H

H

G

G

S

S

T
|
T

F

F

G

G

G

G

N

N

Y

P

L

L

S

A

-

C

-

R

-

A

-

G

T

T

A

V

A

V

A

V

N

D

E

E

V

V

L

E

D

K

I

L

L

L

E

P

E

H

M

V

K

R

E

E

S

V

G

G

A

N

L

-

D

-

E

-

H

-

L

-

L

-

Y

Y

F

F

E

K

T

E

S

K

L

L

A

K

K

E

F

L

A

G

K

K

A

G

H

K

P

V

A

K

I

-

F

-

L

-

E

-

H

-

V

-

G

G

L

R

G

G

M

L

M

M

R

L

G

G

L

L

R

E

V

-

V

L

D

E

G

R

D

E

T

C

L

K

G

D

K

Y

I

V

I

L

N

K

A

A

A

L

R

E

E

K

A

G

G

L

V

L

I

I

V

N

L

C

K

T

A

A

G

G

R

K

N

-

T

V

L

L

R

R

F

F

L

L

P

P

P

P

L

L

T

I

I

I

T

Q

K

K

S

E

D

H

I

I

D

D

E

R

G

A

F

I

A

S

R

V

L

L

E

R

K

E

A

I

M

L

GT 96:97 (≠ GA 101:102) binding pyridoxal 5'-phosphate
K242 (= K246) modified: N6-(pyridoxal phosphate)lysine
T271 (= T273) binding pyridoxal 5'-phosphate

2eh6A Crystal structure of acetylornithine aminotransferase from aquifex aeolicus vf5
44% identity, 98% coverage: 7:388/391 of query aligns to 1:375/375 of 2eh6A

query
sites
2eh6A

N

T

Y

Y

V

L

L

M

P

N

T

N

Y

Y

A

A

R

R

Q

L

N

P

I

V

N

K

F

F

V

V

A

R

G

G

K

K

N

G

A

V

V

Y

L

L

I

Y

D

D

S

E

E

E

G

G

K

K

E

E

Y

Y

I

L

D

D

F

F

A

V

A

S

G

G

I

I

A

G

V

V

C

N

S

S

V

L

G

G

H

H

A

A

N

Y

E

P

R

K

L

L

T

T

K

E

A

A

I

L

C

K

D

E

Q

Q

V

V

S

E

K

K

V

L

I

L

H

H

V

V

S

S

N

N

L

L

Y

Y

Y

E

I

N

E

P

P

W

Q

Q

A

E

E

E

C

L

A

A

R

H

R

K

I

L

V

V

E

K

M

H

S

F

G

W

Y

T

D

E

M

G

K

K

C

V

F

F

F

F

G

A

N

N

S

S

G
|
G

A
x
T

E

E

A

S

N

V

E

E

G

A

A

A

I

I

K

K

I

L

A

A

R

R

K

K

Y

Y

G

W

E

R

V

D

D

K

G

G

Q

K

P

N

K

K

R

-

Y

W

K

K

I

F

I

I

T

S

L

F

D

E

H

N

S

S

F
|
F

H
|
H

G

G

R

R

T

T

I

Y

T

G

A

S

L

L

K

S

A

A

T

T

G

G

Q

Q

E

P

S

K

M

F

H

H

N

K

Y

G

F

F

G

E

P

P

F

L

P

V

D

P

G

G

F

F

V

S

Y

Y

A

A

K

K

-

L

-

N

N

D

I

I

D

D

E

S

I

V

E

Y

S

K

L

L

I

L

D

D

E

E

H

E

T

T

V

A

A

G

V

I

M

I

I

I

E
|
E

L

V

V

I

Q

Q

G

G

E

E

G

G

G

G

V

V

Q

N

P

E

Q

A

D

S

R

E

A

D

K

F

V

L

Q

S

A

K

L

L

S

Q

A

E

M

I

L

C

K

K

S

E

R

K

D

D

V

V

L

L

L

L

M

I

V

I

D
|
D

E

E

V
|
V

Q
|
Q

T

T

G

G

I

I

Y

G

R

R

T

T

G

G

E

E

F

F

L

Y

A

A

S

Y

N

Q

L

H

Y

F

G

N

I

L

E

K

P

P

D

D

V

V

I

I

T

A

L

L

A

A

K
|
K

G

G

L

L

G

G

G

G

G

G

V

V

P

P

I

I

G

G

V

A

V

I

M

L

T

A

G

R

K

E

K

E

-

V

-

A

D

Q

I

S

F

F

S

T

P

P

G

G

D

S

H

H

G

G

S

S

T
|
T

F

F

G

G

G

G

N

N

Y

P

L

L

S

A

-

C

-

R

-

A

-

G

T

T

A

V

A

V

A

V

N

D

E

E

V

V

L

E

D

K

I

L

L

L

E

P

E

H

M

V

K

R

E

E

S

V

G

G

A

N

L

-

D

-

E

-

H

-

L

-

L

-

Y

Y

F

F

E

K

T

E

S

K

L

L

A

K

K

E

F

L

A

G

K

K

A

G

H

K

P

V

A

K

I

-

F

-

L

-

E

-

H

-

V

-

G

G

L

R

G

G

M

L

M

M

R

L

G

G

L

L

R

E

V

-

V

L

D

E

G

R

D

E

T

C

L

K

G

D

K

Y

I

V

I

L

N

K

A

A

A

L

R

E

E

K

A

G

G

L

V

L

I

I

V

N

L

C

K

T

A

A

G

G

R

K

N

-

T

V

L

L

R
|
R

F

F

L

L

P

P

P

P

L

L

T

I

I

I

T

Q

K

K

S

E

D

H

I

I

D

D

E

R

G

A

F

I

A

S

R

V

L

L

E

R

K

E

A

I

M

L

active site: F127 (= F134), E179 (= E184), D212 (= D217), Q215 (= Q220), K241 (= K246), T270 (= T273), R352 (= R365)
binding pyridoxal-5'-phosphate: G95 (= G101), T96 (≠ A102), F127 (= F134), H128 (= H135), E179 (= E184), D212 (= D217), V214 (= V219), K241 (= K246)

2ordA Crystal structure of acetylornithine aminotransferase (ec 2.6.1.11) (acoat) (tm1785) from thermotoga maritima at 1.40 a resolution
39% identity, 98% coverage: 8:391/391 of query aligns to 10:393/393 of 2ordA

query
sites
2ordA

Y

Y

V

L

L

M

P

N

T

T

Y

Y

A

S

R

R

Q

F

N

P

I

A

N

T

F

F

V

V

A

Y

G

G

K

K

N

G

A

S

V

W

L

I

I

Y

D

D

S

E

E

K

G

G

K

N

E

A

Y

Y

I

L

D

D

F

F

A

T

A

S

G

G

I

I

A

A

V

V

C

N

S

V

V

L

G

G

H

H

A

S

N

H

E

P

R

R

L

L

T

V

K

E

A

A

I

I

C

K

D

D

Q

Q

V

A

S

E

K

K

V

L

I

I

H

H

V

C

S

S

N

N

L

L

Y

F

Y

W

I

N

E

R

P

P

Q

Q

A

M

E

E

C

L

A

A

R

E

R

-

I

L

V

L

E

S

M

K

S

N

G

T

Y

F

D

G

M

G

K

K

C

V

F

F

F

F

G

A

N

N

S

T

G
|
G

A
x
T

E

E

A

A

N

N

E

E

G

A

A

A

I

I

K

K

I

I

A

A

R

R

K

K

Y

Y

G

G

E

K

V

K

D

K

G

S

Q

E

P

-

K

K

R

K

Y

Y

K

R

I

I

I

L

T

S

L

A

D

H

H

N

S

S

F
|
F

H
|
H

G

G

R

R

T

T

I

L

T

G

A

S

L

L

K

T

A

A

T

T

G

G

Q

Q

E

P

S

K

M

Y

H

Q

N

K

Y

P

F

F

G

E

P

P

F

L

P

V

D

P

G

G

F

F

V

E

Y

Y

A

F

K

E

-

F

-

N

N

N

I

V

D

E

E

D

I

L

E

R

S

R

L

K

I

M

D

S

E

E

H

D

T

V

V

C

A

A

V

V

M

F

I

L

E
|
E

L

P

V

I

Q

Q

G

G

E

E

G

S

G

G

V

I

Q

V

P

P

Q

A

D

T

R

K

A

E

K

F

V

L

Q

E

A

E

L

A

S

R

A

K

M

L

L

C

K

D

S

E

R

Y

D

D

V

A

L

L

L

L

M

V

V

F

D
|
D

E

E

V
|
V

Q
|
Q

T

C

G

G

I

M

Y

G

R

R

T

T

G

G

E

K

F

L

L

F

A

A

S

Y

N

Q

L

K

Y

Y

G

G

I

V

E

V

P

P

D

D

V

V

I

L

T

T

L

T

A

A

K
|
K

G

G

L

L

G

G

G

G

G

G

V

V

P

P

I

I

G

G

V

A

V

V

M

I

T

V

G

N

K

E

K

R

-

A

D

N

I

V

F

L

S

E

P

P

G

G

D

D

H

H

G

G

S

T

T
|
T

F

F

G

G

G

G

N

N

Y

P

L

L

S

A

T

C

A

R

A

A

A

G

N

V

E

T

V

V

L

I

D

K

-

E

-

L

-

T

-

K

-

E

-

G

I

F

L

L

E

E

E

E

M

V

K

E

E

E

S

K

G

G

A

N

L

-

D

-

E

-

H

-

L

-

L

-

Y

Y

F

L

E

M

T

K

S

K

L

L

A

Q

K

E

F

M

A

K

K

E

A

E

H

Y

P

D

A

V

I

V

F

-

L

A

E

D

H

V

V

R

G

G

L

M

G

G

M

L

M

M

R

I

G

G

L

I

R

Q

V

F

V

R

D

E

G

E

D

V

T

S

L

N

G

R

K

E

I

V

I

A

N

T

A

K

A

C

R

F

E

E

A

N

G

K

V

L

I

L

V

V

L

V

K

P

A

A

G

G

R

N

N

N

T

T

L

I

R
|
R

F

F

L

L

P

P

P

P

L

L

T

T

I

V

T

E

K

Y

S

G

D

E

I

I

D

D

E

L

G

A

F

V

A

E

R

T

L

L

E

K

K

K

A

V

M

L

A

Q

A

G

L

I

active site: F134 (= F134), E186 (= E184), D219 (= D217), Q222 (= Q220), K248 (= K246), T276 (= T273), R367 (= R365)
binding pyridoxal-5'-phosphate: G102 (= G101), T103 (≠ A102), F134 (= F134), H135 (= H135), E186 (= E184), D219 (= D217), V221 (= V219), Q222 (= Q220), K248 (= K246)

Q9X2A5 Acetylornithine aminotransferase; ACOAT; EC 2.6.1.11 from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)
39% identity, 98% coverage: 8:391/391 of query aligns to 2:385/385 of Q9X2A5

query
sites
Q9X2A5

Y

Y

V

L

L

M

P

N

T

T

Y

Y

A

S

R

R

Q

F

N

P

I

A

N

T

F

F

V

V

A

Y

G

G

K

K

N

G

A

S

V

W

L

I

I

Y

D

D

S

E

E

K

G

G

K

N

E

A

Y

Y

I

L

D

D

F

F

A

T

A

S

G

G

I

I

A

A

V

V

C

N

S

V

V

L

G

G

H

H

A

S

N

H

E

P

R

R

L

L

T

V

K

E

A

A

I

I

C

K

D

D

Q

Q

V

A

S

E

K

K

V

L

I

I

H

H

V

C

S

S

N

N

L

L

Y

F

Y

W

I

N

E

R

P

P

Q

Q

A

M

E

E

C

L

A

A

R

E

R

-

I

L

V

L

E

S

M

K

S

N

G

T

Y

F

D

G

M

G

K

K

C

V

F

F

F

F

G

A

N

N

S

T

G
|
G

A
x
T

E

E

A

A

N

N

E

E

G

A

A

A

I

I

K

K

I

I

A

A

R

R

K

K

Y

Y

G

G

E

K

V

K

D

K

G

S

Q

E

P

-

K

K

R

K

Y

Y

K

R

I

I

I

L

T

S

L

A

D

H

H

N

S

S

F

F

H

H

G

G

R

R

T

T

I

L

T

G

A

S

L

L

K

T

A

A

T

T

G

G

Q

Q

E

P

S

K

M

Y

H

Q

N

K

Y

P

F

F

G

E

P

P

F

L

P

V

D

P

G

G

F

F

V

E

Y

Y

A

F

K

E

-

F

-

N

N

N

I

V

D

E

E

D

I

L

E

R

S

R

L

K

I

M

D

S

E

E

H

D

T

V

V

C

A

A

V

V

M

F

I

L

E

E

L

P

V

I

Q

Q

G

G

E

E

G

S

G

G

V

I

Q

V

P

P

Q

A

D

T

R

K

A

E

K

F

V

L

Q

E

A

E

L

A

S

R

A

K

M

L

L

C

K

D

S

E

R

Y

D

D

V

A

L

L

L

L

M

V

V

F

D

D

E

E

V

V

Q

Q

T

C

G

G

I

M

Y

G

R

R

T

T

G

G

E

K

F

L

L

F

A

A

S

Y

N

Q

L

K

Y

Y

G

G

I

V

E

V

P

P

D

D

V

V

I

L

T

T

L

T

A

A

K

K

G

G

L

L

G

G

G

G

G

G

V

V

P

P

I

I

G

G

V

A

V

V

M

I

T

V

G

N

K

E

K

R

-

A

D

N

I

V

F

L

S

E

P

P

G

G

D

D

H

H

G

G

S

T

T
|
T

F

F

G

G

G

G

N

N

Y

P

L

L

S

A

T

C

A

R

A

A

A

G

N

V

E

T

V

V

L

I

D

K

-

E

-

L

-

T

-

K

-

E

-

G

I

F

L

L

E

E

E

E

M

V

K

E

E

E

S

K

G

G

A

N

L

-

D

-

E

-

H

-

L

-

L

-

Y

Y

F

L

E

M

T

K

S

K

L

L

A

Q

K

E

F

M

A

K

K

E

A

E

H

Y

P

D

A

V

I

V

F

-

L

A

E

D

H

V

V

R

G

G

L

M

G

G

M

L

M

M

R

I

G

G

L

I

R

Q

V

F

V

R

D

E

G

E

D

V

T

S

L

N

G

R

K

E

I

V

I

A

N

T

A

K

A

C

R

F

E

E

A

N

G

K

V

L

I

L

V

V

L

V

K

P

A

A

G

G

R

N

N

N

T

T

L

I

R

R

F

F

L

L

P

P

P

P

L

L

T

T

I

V

T

E

K

Y

S

G

D

E

I

I

D

D

E

L

G

A

F

V

A

E

R

T

L

L

E

K

K

K

A

V

M

L

A

Q

A

G

L

I

GT 94:95 (≠ GA 101:102) binding pyridoxal 5'-phosphate
T268 (= T273) binding pyridoxal 5'-phosphate

4adbB Structural and functional study of succinyl-ornithine transaminase from e. Coli (see paper)
38% identity, 98% coverage: 3:387/391 of query aligns to 6:394/401 of 4adbB

query
sites
4adbB

K

E

N

N

F

F

E

D

N

E

Y

W

V

M

L

I

P

P

T

V

Y

Y

A

A

R

P

Q

A

N

P

I

F

N

I

F

P

V

V

A

R

G

G

K

E

N

G

A

S

V

R

L

L

I

W

D

D

S

Q

E

Q

G

G

K

K

E

E

Y

Y

I

I

D

D

F

F

A

A

A

G

G

G

I

I

A

A

V

V

C

N

S

A

V

L

G

G

H

H

A

A

N

H

E

P

R

E

L

L

T

R

K

E

A

A

I

L

C

N

D

E

Q

Q

V

A

S

S

K

K

V

F

I

W

H

H

V

T

S

G

N

N

L

G

Y

Y

Y

T

I

N

E

E

P

P

Q

V

A

L

E

R

C

L

A

A

R

K

R

K

I

L

V

I

E

D

M

A

S

T

G

F

Y

A

D

D

M

-

K

R

C

V

F

F

F

F

G

C

N

N

S
|
S

G
|
G

A
|
A

E

E

A

A

N

N

E

E

G

A

A

A

I

L

K

K

I

L

A

A

R

R

K

K

Y

F

G

A

E

H

V

D

D

R

G

Y

Q

G

P

S

K

H

R

K

Y

S

K

G

I

I

I

V

T

A

L

F

D

K

H

N

S

A

F
|
F

H
|
H

G

G

R

R

T

T

I

L

T

F

A

T

L

V

K

S

A

A

T

G

G

G

Q

Q

E

P

S

A

M

Y

H

S

N

Q

Y

D

F

F

G

A

P

P

F

L

P

P

D

A

G

D

F

I

V

R

Y

H

A

A

-

A

-

Y

K

N

N

D

I

I

D

N

E

S

I

A

E

S

S

A

L

L

I

I

D

D

E

D

H

S

T

T

V

C

A

A

V

V

M

I

I

V

E
|
E

L

P

V

I

Q

Q

G

G

E

E

G

G

G

G

V

V

Q

V

P

P

Q

A

D

S

R

N

A

A

K

F

V

L

Q

Q

A

G

L

L

S

R

A

E

M

L

L

C

K

N

S

R

R

H

D

N

V

A

L

L

L

L

M

I

V

F

D
|
D

E

E

V
|
V

Q
|
Q

T

T

G

G

I

V

Y

G

R

R

T

T

G

G

E

E

F

L

L

Y

A

A

S

Y

N

M

L

H

Y

Y

G

G

I

V

E

T

P

P

D

D

V

L

I

L

T

T

L

T

A

A

K
|
K

G

A

L

L

G

G

G

G

G

G

V

F

P

P

I

V

G

G

V

A

V

L

M

L

T

A

G

T

K

E

K

E

-

C

-

A

D

R

I

V

F

M

S

T

P

V

G

G

D

T

H

H

G

G

S

T

T
|
T

F

Y

G

G

G

G

N

N

Y

P

L

L

S

A

T

S

A

A

A

V

A

A

N

G

E

K

V

V

L

L

D

E

I

L

L

I

E

N

E

T

M

P

K

E

E

M

S

L

G

N

A

G

L

V

D

K

E

Q

H

R

L

H

L

D

Y

W

F

F

E

V

T

E

S

R

L

L

A

N

K

T

F

I

A

N

K

H

A

R

H

Y

P

-

A

G

I

L

F

F

L

S

E

E

H

V

V

R

G

G

L

L

G

G

M

L

M

L

R

I

G

G

L

C

R

-

V

V

V

L

D

N

G

A

D

D

T

Y

L

A

G

G

-

Q

-

A

-

K

K

Q

I

I

I

S

N

Q

A

E

A

A

R

A

E

K

A

A

G

G

V

V

I

M

V

V

L

L

K

I

A

A

G

G

R

G

N

N

T

V

L

V

R
|
R

F

F

L

A

P

P

P

A

L

L

T

N

I

V

T

S

K

E

S

E

D

E

I

V

D

T

E

T

G

G

F

L

A

D

R

R

L

F

E

A

K

A

A

A

active site: F136 (= F134), E188 (= E184), D221 (= D217), Q224 (= Q220), K250 (= K246), T279 (= T273), R372 (= R365)
binding pyridoxal-5'-phosphate: S102 (= S100), G103 (= G101), A104 (= A102), F136 (= F134), H137 (= H135), D221 (= D217), V223 (= V219), Q224 (= Q220), K250 (= K246)

4addA Structural and functional study of succinyl-ornithine transaminase from e. Coli (see paper)
38% identity, 98% coverage: 3:387/391 of query aligns to 6:394/400 of 4addA

query
sites
4addA

K

E

N

N

F

F

E

D

N

E

Y

W

V

M

L

I

P

P

T

V

Y
|
Y

A

A

R

P

Q

A

N

P

I

F

N

I

F

P

V

V

A

R

G

G

K

E

N

G

A

S

V

R

L

L

I

W

D

D

S

Q

E

Q

G

G

K

K

E

E

Y

Y

I

I

D

D

F

F

A

A

A

G

G

G

I

I

A

A

V

V

C

N

S

A

V

L

G

G

H

H

A

A

N

H

E

P

R

E

L

L

T

R

K

E

A

A

I

L

C

N

D

E

Q

Q

V

A

S

S

K

K

V

F

I

W

H

H

V

T

S

G

N

N

L

G

Y

Y

Y

T

I

N

E

E

P

P

Q

V

A

L

E

R

C

L

A

A

R

K

R

K

I

L

V

I

E

D

M

A

S

T

G

F

Y

A

D

D

M

-

K

R

C

V

F

F

F

F

G

C

N

N

S

S

G
|
G

A
|
A

E

E

A

A

N

N

E

E

G

A

A

A

I

L

K

K

I

L

A

A

R

R

K

K

Y

F

G

A

E

H

V

D

D

R

G

Y

Q

G

P

S

K

H

R

K

Y

S

K

G

I

I

I

V

T

A

L

F

D

K

H

N

S

A

F
|
F

H
|
H

G

G

R
|
R

T

T

I

L

T

F

A

T

L

V

K

S

A

A

T

G

G

G

Q

Q

E

P

S

A

M

Y

H

S

N

Q

Y

D

F

F

G

A

P

P

F

L

P

P

D

A

G

D

F

I

V

R

Y

H

A

A

-

A

-

Y

K

N

N

D

I

I

D

N

E

S

I

A

E

S

S

A

L

L

I

I

D

D

E

D

H

S

T

T

V

C

A

A

V

V

M

I

I

V

E
|
E

L

P

V

I

Q

Q

G

G

E

E

G

G

G

G

V

V

Q

V

P

P

Q

A

D

S

R

N

A

A

K

F

V

L

Q

Q

A

G

L

L

S

R

A

E

M

L

L

C

K

N

S

R

R

H

D

N

V

A

L

L

L

L

M

I

V

F

D
|
D

E

E

V
|
V

Q
|
Q

T

T

G

G

I

V

Y

G

R

R

T

T

G

G

E

E

F

L

L

Y

A

A

S

Y

N

M

L

H

Y

Y

G

G

I

V

E

T

P

P

D

D

V

L

I

L

T

T

L

T

A

A

K
|
K

G

A

L

L

G

G

G

G

G

G

V

F

P

P

I

V

G

G

V

A

V

L

M

L

T

A

G

T

K

E

K

E

-

C

-

A

D

R

I

V

F

M

S

T

P

V

G

G

D

T

H

H

G

G

S

T

T
|
T

F

Y

G

G

G

G

N

N

Y

P

L

L

S

A

T

S

A

A

A

V

A

A

N

G

E

K

V

V

L

L

D

E

I

L

L

I

E

N

E

T

M

P

K

E

E

M

S

L

G

N

A

G

L

V

D

K

E

Q

H

R

L

H

L

D

Y

W

F

F

E

V

T

E

S

R

L

L

A

N

K

T

F

I

A

N

K

H

A

R

H

Y

P

-

A

G

I

L

F

F

L

S

E

E

H

V

V

R

G

G

L

L

G

G

M

L

M

L

R

I

G

G

L

C

R

-

V

V

V

L

D

N

G

A

D

D

T

Y

L

A

G

G

-

Q

-

A

-

K

K

Q

I

I

I

S

N

Q

A

E

A

A

R

A

E

K

A

A

G

G

V

V

I

M

V

V

L

L

K

I

A

A

G

G

R

G

N

N

T

V

L

V

R
|
R

F

F

L

A

P

P

P

A

L

L

T

N

I

V

T

S

K

E

S

E

D

E

I

V

D

T

E

T

G

G

F

L

A

D

R

R

L

F

E

A

K

A

A

A

active site: F136 (= F134), E188 (= E184), D221 (= D217), Q224 (= Q220), K250 (= K246), T279 (= T273), R372 (= R365)
binding pyridoxal-5'-phosphate: G103 (= G101), A104 (= A102), F136 (= F134), H137 (= H135), D221 (= D217), V223 (= V219), K250 (= K246)
binding n~2~-(3-carboxypropanoyl)-l-ornithine: Y16 (= Y13), F136 (= F134), R139 (= R137)

3nx3A Crystal structure of acetylornithine aminotransferase (argd) from campylobacter jejuni
38% identity, 99% coverage: 6:391/391 of query aligns to 1:388/388 of 3nx3A

query
sites
3nx3A

E

Q

N

S

Y

H

V

I

L

I

P

P

T

T

Y

Y

A

K

R

R

Q

F

N

D

I

I

N

V

F

L

V

E

A

K

G

G

K

Q

N

G

A

V

V

Y

L

L

I

F

D

D

S

D

E

K

G

A

K

K

E

K

Y

Y

I

L

D

D

F

F

A

S

A

S

G

G

I

I

A

G

V

V

C

C

S

A

V

L

G

G

H

Y

A

N

N

H

E

A

R

K

L

F

T

N

K

A

A

K

I

I

C

K

D

A

Q

Q

V

V

S

D

K

K

V

L

I

L

H

H

V

T

S

S

N

N

L

L

Y

Y

Y

Y

I

N

E

E

P

N

Q

I

A

A

E

A

C

A

A

A

R

K

R

N

I

L

V

A

E

K

M

A

S

S

G

A

Y

L

D

E

M

-

K

R

C

V

F

F

F

F

G

T

N

N

S

S

G

G

A

T

E

E

A

S

N

I

E

E

G

G

A

A

I

M

K

K

I

T

A

A

R

R

K

K

Y

Y

G

A

E

F

V

N

D

K

G

G

Q

-

P

V

K

K

R

G

Y

G

K

Q

I

F

I

I

T

A

L

F

D

K

H

H

S

S

F
|
F

H

H

G

G

R

R

T

T

I

L

T

G

A

A

L

L

K

S

A

L

T

T

G

A

Q

N

E

E

S

K

M

Y

H

Q

N

K

Y

P

F

F

G

K

P

P

F

L

P

I

D

S

G

G

F

V

V

K

Y

F

A

A

K

K

-

Y

-

N

N

D

I

I

D

S

E

S

I

V

E

E

S

K

L

L

I

V

D

N

E

E

H

K

T

T

V

C

A

A

V

I

M

I

I

L

E
|
E

L

S

V

V

Q

Q

G

G

E

E

G

G

G

G

V

I

Q

N

P

P

Q

A

D
x
N

R

K

A

D

K
x
F

V

Y

Q

K

A

A

L

L

S

R

A

K

M

L

L

C

K

D

S

E

R

K

D

D

V

I

L

L

L

L

M

I

V

A

D
|
D

E

E

V

I

Q
|
Q

T

C

G

G

I

M

Y

G

R

R

T

S

G

G

E

K

F

F

L

F

A

A

S

Y

N

E

L

H

Y

A

G

Q

I

I

E

L

P

P

D

D

V

I

I

M

T

T

L

S

A

A

K
|
K

G

A

L

L

G

G

G

C

G

G

V

L

P

S

I

V

G

G

V

A

V

F

M

V

T

I

G

N

K

Q

K

K

-

V

-

A

-

S

D

N

I

S

F

L

S

E

P

A

G

G

D

D

H

H

G

G

S

S

T
|
T

F

Y

G

G

G

G

N

N

Y

P

L

L

S

V

T

C

A

A

A

G

A

V

N

N

E

A

V

V

L

F

D

E

I

I

L

F

E

K

E

E

M

E

K

K

E

I

S

L

G

E

A

N

L

V

D

N

E

K

H

L

L

T

L

P

Y

Y

F

L

E

E

T

Q

S

S

L

L

A

D

K

E

F

L

A
x
I

K

N

A

E

H
x
F

P
x
D

A

-

I

F

F
x
C

L

K

E

K

H

R

V

K

G

G

L

L

G

G

M

F

M

M

R

Q

G

G

L

L

R

S

V

L

V

D

D

K

G

S

D

V

T

K

L

V

G

A

K

K

I

V

I

I

N

Q

A

K

A

C

R

Q

E

E

A

N

G

A

V

L

I

L

V

L

L

I

K

S

A

C

G

G

R

E

N

N

T

D

L

L

R
|
R

F

F

L

L

P

P

P

P

L

L

T

I

I

L

T
x
Q

K
|
K

S

E

D

H

I

I

D

D

E

E

G

M

F

S

A

E

R

K

L

L

E

R

K

K

A

A

M

L

A

K

A

S

L

F

active site: F127 (= F134), E179 (= E184), D212 (= D217), Q215 (= Q220), K241 (= K246), T271 (= T273), R362 (= R365)
binding magnesium ion: N191 (≠ D196), F194 (≠ K199), I313 (≠ A315), F316 (≠ H318), D317 (≠ P319), C319 (≠ F322), Q370 (≠ T373), K371 (= K374)

4jevB N-acetylornithine aminotransferase from s. Typhimurium complexed with gabaculine
36% identity, 98% coverage: 4:388/391 of query aligns to 7:395/402 of 4jevB

query
sites
4jevB

N

T

F

F

E

D

N

E

Y

V

V

I

L

L

P

P

T

V

Y

Y

A

A

R

P

Q

A

N

D

I

F

N

I

F

P

V

V

A

K

G

G

K

K

N

G

A

S

V

R

L

V

I

W

D

D

S

Q

E

Q

G

G

K

K

E

E

Y

Y

I

I

D

D

F

F

A

A

A

G

G

G

I
|
I

A

A

V

V

C

T

S

A

V

L

G

G

H

H

A

C

N

H

E

P

R

A

L

L

T

V

K

E

A

A

I

L

C

K

D

S

Q

Q

V

G

S

E

K

T

V

L

I

W

H

H

V

T

S

S

N

N

L

V

Y

F

Y

T

I

N

E

E

P

P

Q

A

A

L

E

R

C

L

A

G

R

R

R

K

I

L

V

I

E

D

M

A

S

T

G

-

Y

F

D

A

M

E

K

R

C

V

F

L

F

F

G

M

N

N

S
|
S

G
|
G

A
x
T

E

E

A

A

N

N

E

E

G

T

A

A

I

F

K

K

I

L

A

A

R

R

K

H

Y

Y

G

A

E

C

V

V

D

R

G

H

Q

S

P

P

K

F

R

K

Y

T

K

K

I

I

I

I

T

A

L

F

D

H

H

N

S

A

F
|
F

H
|
H

G

G

R

R

T

S

I

L

T

F

A

T

L

V

K

S

A

V

T

G

G

G

Q

Q

E

P

S

K

M

Y

H

S

N

D

Y

G

F

F

G

G

P

P

F

K

P

P

D

A

G

D

F

I

V

I

Y

H

A

V

-

P

-

F

K

N

N

D

I

L

D

H

E

A

I

V

E

K

S

A

L

V

I

M

D

D

E

D

H

H

T

T

V

C

A

A

V

V

M

V

I

V

E
|
E

L

P

V

I

Q

Q

G

G

E
|
E

G

G

G

G

V

V

Q

Q

P

A

Q

A

D

T

R

P

A

E

K

F

V

L

Q

K

A

G

L

L

S

R

A

D

M

L

L

C

K

D

S

E

R

H

D

Q

V

A

L

L

L

L

M

V

V

F

D
|
D

E

E

V
|
V

Q
|
Q

T

C

G

G

I

M

Y

G

R

R

T

T

G

G

E

D

F

L

L

F

A

A

S

Y

N

M

L

H

Y

Y

G

G

I

V

E

T

P

P

D

D

V

I

I

L

T

T

L

S

A

A

K
|
K

G

A

L

L

G

G

G

G

G

G

V

F

P

P

I

V

G

S

V

A

V

M

M

L

T

T

G

T

K

Q

K

E

-

I

-

A

D

S

I

A

F

F

S

H

P

V

G

G

D

S

H

H

G

G

S

S

T
|
T

F

Y

G

G

G

G

N

N

Y

P

L

L

S

A

T

C

A

A

A

V

A

A

N

G

E

A

V

T

L

F

D

D

I

I

L

I

E

N

E

T

M

-

K

-

E

-

S

-

G

-

A

-

L

-

D

P

E

E

H

V

L

L

L

Q

Y

G

F

I

E

H

T

T

S

K

L

R

A

Q

K

Q

F

F

A

V

K

Q

A

H

H

L

P

Q

A

A

I

I

F

D

L

E

E

Q

H

F

V

D

G

I

L

F

G

S

M

D

M

I

R

R

G

G

L

M

R

G

V

L

V

L

D

I

G

G

D

A

T

E

L

L

G

K

K

P

-

K

-

Y

-

K

-

G

-

R

-

A

-

R

-

D

I

F

I

L

N

Y

A

A

A

G

R

A

E

E

A

A

G

G

V

V

I

M

V

V

L

L

K

N

A

A

G

G

R

A

N

D

T

V

L

M

R
|
R

F

F

L

A

P

P

P

S

L

L

T

V

I

V

T

E

K

E

S

A

D

D

I

I

D

H

E

E

G

G

F

M

A

Q

R

R

L

F

E

A

K

Q

A

A

M

V

active site: F136 (= F134), E188 (= E184), D221 (= D217), Q224 (= Q220), K250 (= K246), T279 (= T273), R372 (= R365)
binding 3-[o-phosphonopyridoxyl]--amino-benzoic acid: I46 (= I43), S102 (= S100), G103 (= G101), T104 (≠ A102), F136 (= F134), H137 (= H135), E188 (= E184), E193 (= E189), D221 (= D217), V223 (= V219), Q224 (= Q220), K250 (= K246), R372 (= R365)

P40732 Acetylornithine/succinyldiaminopimelate aminotransferase; ACOAT; DapATase; Succinyldiaminopimelate transferase; EC 2.6.1.11; EC 2.6.1.17 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
36% identity, 98% coverage: 4:388/391 of query aligns to 12:400/405 of P40732

query
sites
P40732

N

T

F

F

E

D

N

E

Y

V

V

I

L

L

P

P

T

V

Y

Y

A

A

R

P

Q

A

N

D

I

F

N

I

F

P

V

V

A

K

G

G

K

K

N

G

A

S

V

R

L

V

I

W

D

D

S

Q

E

Q

G

G

K

K

E

E

Y

Y

I

I

D

D

F

F

A

A

A

G

G

G

I

I

A

A

V

V

C

T

S

A

V

L

G

G

H

H

A

C

N

H

E

P

R

A

L

L

T

V

K

E

A

A

I

L

C

K

D

S

Q

Q

V

G

S

E

K

T

V

L

I

W

H

H

V

T

S

S

N

N

L

V

Y

F

Y

T

I

N

E

E

P

P

Q

A

A

L

E

R

C

L

A

G

R

R

R

K

I

L

V

I

E

D

M

A

S

T

G

-

Y

F

D

A

M

E

K

R

C

V

F

L

F

F

G

M

N

N

S

S

G
|
G

A
x
T

E

E

A

A

N

N

E

E

G

T

A

A

I

F

K

K

I

L

A

A

R

R

K

H

Y

Y

G

A

E

C

V

V

D

R

G

H

Q

S

P

P

K

F

R

K

Y

T

K

K

I

I

I

I

T

A

L

F

D

H

H

N

S

A

F

F

H

H

G

G

R

R

T

S

I

L

T

F

A

T

L

V

K

S

A

V

T

G

G

G

Q

Q

E

P

S

K

M

Y

H

S

N

D

Y

G

F

F

G

G

P

P

F

K

P

P

D

A

G

D

F

I

V

I

Y

H

A

V

-

P

-

F

K

N

N

D

I

L

D

H

E

A

I

V

E

K

S

A

L

V

I

M

D

D

E

D

H

H

T

T

V

C

A

A

V

V

M

V

I

V

E

E

L

P

V

I

Q

Q

G

G

E

E

G

G

G

G

V

V

Q

Q

P

A

Q

A

D

T

R

P

A

E

K

F

V

L

Q

K

A

G

L

L

S

R

A

D

M

L

L

C

K

D

S

E

R

H

D

Q

V

A

L

L

L

L

M

V

V

F

D

D

E

E

V

V

Q

Q

T

C

G

G

I

M

Y

G

R

R

T

T

G

G

E

D

F

L

L

F

A

A

S

Y

N

M

L

H

Y

Y

G

G

I

V

E

T

P

P

D

D

V

I

I

L

T

T

L

S

A

A

K
|
K

G

A

L

L

G

G

G

G

G

G

V

F

P

P

I

V

G

S

V

A

V

M

M

L

T

T

G

T

K

Q

K

E

-

I

-

A

D

S

I

A

F

F

S

H

P

V

G

G

D

S

H

H

G

G

S

S

T
|
T

F

Y

G

G

G

G

N

N

Y

P

L

L

S

A

T

C

A

A

A

V

A

A

N

G

E

A

V

A

L

F

D

D

I

I

L

I

E

N

E

T

M

-

K

-

E

-

S

-

G

-

A

-

L

-

D

P

E

E

H

V

L

L

L

Q

Y

G

F

I

E

H

T

T

S

K

L

R

A

Q

K

Q

F

F

A

V

K

Q

A

H

H

L

P

Q

A

A

I

I

F

D

L

E

E

Q

H

F

V

D

G

I

L

F

G

S

M

D

M

I

R

R

G

G

L

M

R

G

V

L

V

L

D

I

G

G

D

A

T

E

L

L

G

K

K

P

-

K

-

Y

-

K

-

G

-

R

-

A

-

R

-

D

I

F

I

L

N

Y

A

A

A

G

R

A

E

E

A

A

G

G

V

V

I

M

V

V

L

L

K

N

A

A

G

G

R

A

N

D

T

V

L

M

R

R

F

F

L

A

P

P

P

S

L

L

T

V

I

V

T

E

K

E

S

A

D

D

I

I

D

H

E

E

G

G

F

M

A

Q

R

R

L

F

E

A

K

Q

A

A

M

V

GT 108:109 (≠ GA 101:102) binding pyridoxal 5'-phosphate
K255 (= K246) modified: N6-(pyridoxal phosphate)lysine
T284 (= T273) binding pyridoxal 5'-phosphate

2pb0A Structure of biosynthetic n-acetylornithine aminotransferase from salmonella typhimurium: studies on substrate specificity and inhibitor binding (see paper)
35% identity, 98% coverage: 4:388/391 of query aligns to 1:384/389 of 2pb0A

query
sites
2pb0A

N

T

F

F

E

D

N

E

Y

V

V

I

L

L

P

P

T

V

Y

Y

A

A

R

P

Q

A

N

D

I

F

N

I

F

P

V

V

A

K

G

G

K

K

N

G

A

S

V

R

L

V

I

W

D

D

S

Q

E

Q

G

G

K

K

E

E

Y

Y

I

I

D

D

F

F

A

A

A

G

G

G

I

I

A

A

V

V

C

T

S

A

V

L

G

G

H

H

A

C

N

H

E

P

R

A

L

L

T

V

K

E

A

A

I

L

C

K

D

S

Q

Q

V

G

S

E

K

T

V

L

I

W

H

H

V

T

S

S

N

N

L

V

Y

F

Y

T

I

N

E

E

P

P

Q

A

A

L

E

R

C

L

A

G

R

R

R

K

I

L

V

I

E

D

M

A

S

T

G

-

Y

F

D

A

M

E

K

R

C

V

F

L

F

F

G

M

N

N

S
|
S

G
|
G

A
x
T

E

E

A

A

N

N

E

E

G

T

A

A

I

F

K

K

I

L

A

A

R

R

K

H

Y

Y

G

A

E

C

V

V

D

R

G

H

Q

S

P

P

K

F

R

K

Y

T

K

K

I

I

I

I

T

A

L

F

D

H

H

N

S

A

F
|
F

H
|
H

G

G

R

R

T

S

I

L

T

F

A

T

L

V

K

S

A

V

T

G

G

G

Q

Q

E

P

S

K

M

Y

H

S

N

D

Y

G

F

F

G

G

P

P

F

K

P

P

D

A

G

D

F

I

V

I

Y

H

A

V

-

P

-

F

K

N

N

D

I

L

D

H

E

A

I

V

E

K

S

A

L

V

I

M

D

D

E

D

H

H

T

T

V

C

A

A

V

V

M

V

I

V

E
|
E

L

P

V

I

Q

Q

G

G

E

E

G

G

G

G

V

V

Q

Q

P

A

Q

A

D

T

R

P

A

E

K

F

V

L

Q

K

A

G

L

L

S

R

A

D

M

L

L

C

K

D

S

E

R

H

D

Q

V

A

L

L

L

L

M

V

V

F

D
|
D

E

E

V
|
V

Q
|
Q

T

C

G

G

I

M

Y

G

R

R

T

T

G

G

E

D

F

L

L

F

A

A

S

Y

N

M

L

H

Y

Y

G

G

I

V

E

T

P

P

D

D

V

I

I

L

T

T

L

S

A

A

K
|
K

G

A

L

L

G

G

G

G

G

G

V

F

P

P

I

V

G

S

V

A

V

M

M

L

T

T

G

-

K

T

K

Q

D

E

I

I

F

A

S

S

P

A

G

-

D

-

H

F

G

G

S

S

T
|
T

F

Y

G

G

G

G

N

N

Y

P

L

L

S

A

T

C

A

A

A

V

A

A

N

G

E

A

V

A

L

F

D

D

I

I

L

I

E

N

E

T

M

-

K

-

E

-

S

-

G

-

A

-

L

-

D

P

E

E

H

V

L

L

L

Q

Y

G

F

I

E

H

T

T

S

K

L

R

A

Q

K

Q

F

F

A

V

K

Q

A

H

H

L

P

Q

A

A

I

I

F

D

L

E

E

Q

H

F

V

D

G

I

L

F

G

S

M

D

M

I

R

R

G

G

L

M

R

G

V

L

V

L

D

I

G

G

D

A

T

E

L

L

G

K

K

P

-

K

-

Y

-

K

-

G

-

R

-

A

-

R

-

D

I

F

I

L

N

Y

A

A

A

G

R

A

E

E

A

A

G

G

V

V

I

M

V

V

L

L

K

N

A

A

G

G

R

A

N

D

T

V

L

M

R
|
R

F

F

L

A

P

P

P

S

L

L

T

V

I

V

T

E

K

E

S

A

D

D

I

I

D

H

E

E

G

G

F

M

A

Q

R

R

L

F

E

A

K

Q

A

A

M

V

active site: F130 (= F134), E182 (= E184), D215 (= D217), Q218 (= Q220), K244 (= K246), T268 (= T273), R361 (= R365)
binding pyridoxal-5'-phosphate: S96 (= S100), G97 (= G101), T98 (≠ A102), F130 (= F134), H131 (= H135), E182 (= E184), D215 (= D217), V217 (= V219), Q218 (= Q220), K244 (= K246)

4jewA N-acetylornithine aminotransferase from s. Typhimurium complexed with l-canaline
35% identity, 98% coverage: 4:388/391 of query aligns to 7:390/397 of 4jewA

query
sites
4jewA

N

T

F

F

E

D

N

E

Y

V

V

I

L

L

P

P

T

V

Y

Y

A

A

R

P

Q

A

N

D

I

F

N

I

F

P

V

V

A
x
K

G

G

K
|
K

N

G

A

S

V

R

L

V

I
x
W

D

D

S

Q

E

Q

G

G

K

K

E

E

Y

Y

I

I

D

D

F

F

A

A

A

G

G

G

I

I

A

A

V

V

C

T

S

A

V

L

G

G

H

H

A

C

N

H

E

P

R

A

L

L

T

V

K

E

A

A

I

L

C

K

D

S

Q

Q

V

G

S

E

K

T

V

L

I

W

H

H

V

T

S

S

N

N

L

V

Y

F

Y

T

I

N

E

E

P

P

Q

A

A

L

E

R

C

L

A

G

R

R

R

K

I

L

V

I

E

D

M

A

S

T

G

-

Y

F

D

A

M

E

K

R

C

V

F

L

F

F

G

M

N

N

S

S

G
|
G

A
x
T

E

E

A

A

N

N

E

E

G

T

A

A

I

F

K

K

I

L

A

A

R

R

K

H

Y

Y

G

A

E

C

V

V

D

R

G

H

Q

S

P

P

K

F

R

K

Y

T

K

K

I

I

I

I

T

A

L

F

D

H

H

N

S

A

F
|
F

H
|
H

G

G

R
|
R

T

S

I

L

T

F

A

T

L

V

K

S

A

V

T

G

G

G

Q

Q

E

P

S

K

M

Y

H

S

N

D

Y

G

F

F

G

G

P

P

F

K

P

P

D

A

G

D

F

I

V

I

Y

H

A

V

-

P

-

F

K

N

N

D

I

L

D

H

E

A

I

V

E

K

S

A

L

V

I

M

D

D

E

D

H

H

T

T

V

C

A

A

V

V

M

V

I

V

E
|
E

L

P

V

I

Q

Q

G

G

E
|
E

G

G

G

G

V

V

Q

Q

P

A

Q

A

D

T

R

P

A

E

K

F

V

L

Q

K

A

G

L

L

S

R

A

D

M

L

L

C

K

D

S

E

R

H

D

Q

V

A

L

L

L

L

M

V

V

F

D
|
D

E

E

V
|
V

Q
|
Q

T

C

G

G

I

M

Y

G

R

R

T

T

G

G

E

D

F

L

L

F

A

A

S

Y

N

M

L

H

Y

Y

G

G

I

V

E

T

P

P

D

D

V

I

I

L

T

T

L

S

A

A

K
|
K

G

A

L

L

G

G

G

G

G

G

V

F

P

P

I

V

G

S

V

A

V

M

M

L

T

T

G

-

K

T

K

Q

D

E

I

I

F

A

S

S

P

A

G

-

D

-

H

F

G

G

S

S

T
|
T

F

Y

G

G

G

G

N

N

Y

P

L

L

S

A

T

C

A

A

A

V

A

A

N

G

E

A

V

T

L

F

D

D

I

I

L

I

E

N

E

T

M

-

K

-

E

-

S

-

G

-

A

-

L

-

D

P

E

E

H

V

L

L

L

Q

Y

G

F

I

E

H

T

T

S

K

L

R

A

Q

K

Q

F

F

A

V

K

Q

A

H

H

L

P

Q

A

A

I

I

F

D

L

E

E

Q

H

F

V

D

G

I

L

F

G

S

M

D

M

I

R

R

G

G

L

M

R

G

V

L

V

L

D

I

G

G

D

A

T

E

L

L

G

K

K

P

-

K

-

Y

-

K

-

G

-

R

-

A

-

R

-

D

I

F

I

L

N

Y

A

A

A

G

R

A

E

E

A

A

G

G

V

V

I

M

V

V

L

L

K

N

A

A

G

G

R

A

N

D

T

V

L

M

R
|
R

F

F

L

A

P

P

P

S

L

L

T

V

I

V

T

E

K

E

S

A

D

D

I

I

D

H

E

E

G

G

F

M

A

Q

R

R

L

F

E

A

K

Q

A

A

M

V

active site: F136 (= F134), E188 (= E184), D221 (= D217), Q224 (= Q220), K250 (= K246), T274 (= T273), R367 (= R365)
binding (2S)-2-azanyl-4-[(E)-[2-methyl-3-oxidanyl-5-(phosphonooxymethyl)pyridin-4-yl]methylideneamino]oxy-butanoic acid: G103 (= G101), T104 (≠ A102), F136 (= F134), H137 (= H135), R139 (= R137), E188 (= E184), E193 (= E189), D221 (= D217), V223 (= V219), K250 (= K246)
binding picric acid: K25 (≠ A22), K27 (= K24), W32 (≠ I29)

Q9M8M7 Acetylornithine aminotransferase, chloroplastic/mitochondrial; ACOAT; Acetylornithine transaminase; AOTA; Protein HOPW1-1-INTERACTING 1; EC 2.6.1.11 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
36% identity, 98% coverage: 9:391/391 of query aligns to 69:456/457 of Q9M8M7

query
sites
Q9M8M7

V

I

L

V

P

G

T

T

Y

Y

A

A

R

R

Q

A

N

P

I

V

N

V

F

L

V

S

A

S

G

G

K

K

N

G

A

C

V

K

L

L

I

F

D

D

S

P

E

E

G

G

K

K

E

E

Y

Y

I

L

D

D

F

C

A

A

A

S

G

G

I

I

A

A

V

V

C

N

S

A

V

L

G

G

H

H

A

G

N

D

E

P

R

D

L

W

T

L

K

R

A

A

I

V

C

T

D

E

Q

Q

V

A

S

G

K

V

V

L

I

A

H

H

V

V

S

S

N

N

L

V

Y

Y

Y

Y

I

T

E

I

P

P

Q

Q

A

I

E

E

C

L

A

A

R

K

R

R

I

L

V

V

E

A

M

S

S

S

G

F

Y

A

D

D

M

-

K

R

C

V

F

F

F

F

G

C

N

N

S

S

G

G

A

T

E

E

A

A

N

N

E

E

G

A

A

A

I

I

K

K

I

F

A

S

R

R

K

K

Y

F

G

Q

E

R

V

F

D

T

G

-

Q

H

P

P

K

E

R

D

Y

K

K

E

I

V

-

A

-

T

-

G

-

F

I

I

T

A

L

F

D

T

H

N

S

S

F

F

H

H

G

G

R

R

T

T

I

L

T

G

A

A

L

L

K

A

A

L

T

T

G

S

Q

K

E

E

S

Q

M

Y

H

R

N

T

Y

P

F

F

G

E

P

P

F

I

P

M

D

P

G

G

F

V

V

T

Y

F

A

L

K

E

-

Y

-

G

N

N

I

I

D

Q

E

A

I

A

E

T

S

D

L

L

I

I

D

R

E

S

H

G

T

K

V

I

-

A

A

A

V

V

M

F

I

V

E

E

L

P

V

I

Q

Q

G

G

E

E

G

G

G

G

V

I

Q

Y

P

S

Q

A

D

T

R

K

A

E

K

F

V

L

Q

Q

A

S

L

L

S

R

A

S

M

A

L

C

K

D

S

A

R

A

D

G

V

S

L

L

L

L

M

V

V