SitesBLAST

3nz2J Crystal structure of hexapeptide-repeat containing-acetyltransferase vca0836 complexed with acetyl co enzyme a from vibrio cholerae o1 biovar eltor
38% identity, 99% coverage: 1:183/185 of query aligns to 2:182/185 of 3nz2J

query
sites
3nz2J

M

M

A

K

E

M

S

S

E

E

R

L

V

E

K

K

M

M

V

L

A

K

G

G

E

E

W

H

Y

F

T

D

C

G

I

A

D

S

D

A

E

E

L

I

E

E

S

A

L

L

R

R

G

S

I

Q

A

A

R

G

D

R

A

L

V

K

F

L

E

E

H

I

N

N

L

Q

-

S

L

L

P

D

P

E

R

A

Q

E

R

R

G

Y

N

A

L

L

G

Q

P

-

G

-

L

-

K

R

A

E

L

L

L

F

G

G

R

H

A

L

G

G

E

H

G

K

A

S

R

C

I

V

E

Q

A

P

P

P

F

F

H

H

C

C

A

E

Y

F

G

G

F

K

N

T

I

I

F

R

L

I

G

G

D

D

G

H

V

T

F

F

L

I

N

N

A

M

G

N

C

V

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V

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M

L

L

D

D

T

G

A

A

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P

V

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R

T

I

I

G

G

K

D

A

H

T

V

L

L

L

I

G
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G

P

P

N

S

V

T

Q

Q

I

F

Y
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Y

C

T

A

A

E

S

H
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H

H

S

K

L

E

D

A

Y

S

R

G

R

R

R

Q

Q

A

A

G

W

L

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I

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C

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P

P

I

I

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I

I

G

E

A

D

N

D

A

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W
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W

I

I

G
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G

G

G

S

N

A

V

V

V

I

I

L

N

G

Q

G

G

V

V

S

T

I

I

G

G

E

A

G

R

A

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I

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V

V

G
x
A

A
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A

G

N

A

S

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x
N

R

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D

D

V

V

A

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N

D

A

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L

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I
x
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x
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P

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A

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R

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x
R

binding acetyl coenzyme *a: G104 (= G105), Y110 (= Y111), H114 (= H115), W138 (= W139), G140 (= G141), A158 (≠ G159), A159 (= A160), N164 (≠ T165), G174 (≠ I175), T176 (≠ N177), P177 (= P178), R182 (≠ K183)

3nz2C Crystal structure of hexapeptide-repeat containing-acetyltransferase vca0836 complexed with acetyl co enzyme a from vibrio cholerae o1 biovar eltor
38% identity, 97% coverage: 4:183/185 of query aligns to 2:179/183 of 3nz2C

query
sites
3nz2C

S

S

E

E

R

L

V

E

K

K

M

M

V

L

A

K

G

G

E

E

W

H

Y

F

T

D

C

G

I

A

D

S

D

A

E

E

L

I

E

E

S

A

L

L

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G

S

I

Q

A

A

R

G

D

R

A

L

V

K

F

L

E

E

H

I

N

N

L

Q

-

S

L

L

P

D

P

E

R

A

Q

E

R

R

G

Y

N

A

L

L

G

Q

P

-

G

-

L

-

K

R

A

E

L

L

L

F

G

G

R

H

A

L

G

G

E

H

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K

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Q

A

P

P

P

F

F

H

H

C

C

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Y

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G

F

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N

T

I

I

F

R

L

I

G

G

D

D

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H

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F

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N

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M

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I

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Y

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H

H

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K

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A

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x
R

binding acetyl coenzyme *a: Y107 (= Y111), H111 (= H115), G137 (= G141), A155 (≠ G159), A156 (= A160), N161 (≠ T165), G171 (≠ I175), T173 (≠ N177), P174 (= P178), L178 (≠ V182), R179 (≠ K183)
binding magnesium ion: N157 (≠ G161), T173 (≠ N177)

1krvA Galactoside acetyltransferase in complex with coa and pnp-beta-gal (see paper)
33% identity, 99% coverage: 1:183/185 of query aligns to 2:182/201 of 1krvA

query
sites
1krvA

M

M

A

P

E

M

S

T

E

E

R

R

V

I

K

R

M

-

V

-

A

A

G

G

E

K

W

L

Y

F

T

T

C
x
D

I

M

D

C

D

E

E

G

L

L

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P

S

E

L

K

R
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R

G

L

I

R

A

G

R

K

D

T

A

L

V

M

F

Y

E

E

H

F

N

N

L

H

L

S

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H

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P

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S

Q

E

R

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G

E

N

K

L

R

G

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P

S

G

L

L

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K

K

A

E

L

M

L

F

G

A

R

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V

G

G

E

E

G

N

A

A

R

W

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V

E

E

A

P

P

P

F

V

H

Y

C

F

A
x
S

Y

Y

G

G

F

S

N

N

I

I

F

H

L

I

G

G

D

R

G

N

V

F

F
x
Y

L

A

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N

A

F

G

N

C

L

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T

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I

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x
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D

D

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D

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I

I

G

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K

D

A

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T

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L

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G
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A

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P

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N

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Y
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S

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x
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x
M

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P

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T

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G

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W

I

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G

G
x
S

S

H

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V

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x
N

G

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G

G

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I

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D

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N

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S

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A
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A

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G

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S

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D

D

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N

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P

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R

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x
R

binding 4-nitrophenyl beta-D-galactopyranoside: D16 (≠ C17), R25 (= R26), S70 (≠ A71), Y82 (≠ F83), N84 (= N85), V90 (≠ L91), D92 (≠ T93), M126 (≠ E127)
binding coenzyme a: A104 (≠ G105), S110 (≠ Y111), T112 (≠ A113), W138 (= W139), G140 (= G141), S141 (≠ G142), N146 (≠ L147), A159 (= A160), P177 (= P178), R179 (= R180), R182 (≠ K183)

1kruA Galactoside acetyltransferase in complex with iptg and coenzyme a (see paper)
33% identity, 99% coverage: 1:183/185 of query aligns to 2:182/201 of 1kruA

query
sites
1kruA

M

M

A

P

E

M

S

T

E

E

R

R

V

I

K

R

M

-

V

-

A

A

G

G

E

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W

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Y

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T

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C
x
D

I

M

D

C

D

E

E

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R

G

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G

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M

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Y

E

E

H

F

N

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H

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K

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M

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G

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N

A

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W

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x
S

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Y

G

G

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N

N

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G

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F
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L

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A

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V

D

D

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D

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G

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D

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L

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P

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H

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M

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N

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A

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W

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x
S

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A

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G

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D

D

V

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N

N

A

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I

A

G

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N

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P

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C

R

R

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K
x
R

binding coenzyme a: H114 (= H115), W138 (= W139), G140 (= G141), S141 (≠ G142), G158 (= G159), A159 (= A160), P177 (= P178), R182 (≠ K183)
binding 1-methylethyl 1-thio-beta-D-galactopyranoside: D16 (≠ C17), P22 (≠ E23), R25 (= R26), W62 (≠ R63), S70 (≠ A71), Y82 (≠ F83), Y82 (≠ F83), N84 (= N85), V90 (≠ L91), D92 (≠ T93), L102 (= L103), H114 (= H115), M126 (≠ E127)

P07464 Galactoside O-acetyltransferase; GAT; Acetyl-CoA:galactoside 6-O-acetyltransferase; Thiogalactoside acetyltransferase; Thiogalactoside transacetylase; EC 2.3.1.18 from Escherichia coli (strain K12) (see 3 papers)
33% identity, 99% coverage: 1:183/185 of query aligns to 3:183/203 of P07464

query
sites
P07464

M

M

A

P

E

M

S

T

E

E

R

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K

R

M

-

V

-

A

A

G

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E

K

W

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x
D

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M

D

C

D

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E

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R

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A

G

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D

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L

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M

F

Y

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E

H

F

N

N

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H

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H

P

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Q

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G

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N

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L

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K

K

A

E

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M

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G

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E

G

N

A

A

R

W

I

V

E

E

A

P

P

P

F

V

H

Y

C

F

A
x
S

Y

Y

G

G

F

S

N

N

I

I

F

H

L

I

G

G

D

R

G

N

V

F

F

Y

L

A

N
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N

A

F

G

N

C

L

T

T

I

I

L

V

D

D

T
x
D

A

Y

S

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R

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I

I

G

G

K

D

A

N

T

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L

L

L

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A

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P

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N

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V

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T

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S

C

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H
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H

H

P

K

V

E

H

A

H

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E

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L

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K

A

N

G

G

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E

M

I

Y

A

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P

P

I

I

E

T

I

I

G

G

A

N

N

N

A

V

W

W

I

I

G

G

G
x
S

S

H

A

V

V

V

I

I

L

N

G

P

G

G

V

V

S

T

I

I

G

G

E

D

G

N

A

S

I

V

V

I

G

G

A
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A

G

G

A

S

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T

R
x
K

D

D

V

I

A

P

N

N

A

V

T

V

V

A

I

A

G

G

N

V

P

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A

C

R
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R

P

V

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x
R

D17 (≠ C17) binding substrate
S71 (≠ A71) binding substrate
N85 (= N85) binding in other chain; binding in other chain
D93 (≠ T93) binding substrate
H115 (= H115) mutation to A: Results in an 1800-fold decrease in catalytic activity.
S142 (≠ G142) binding in other chain
A160 (= A160) binding in other chain
TK 165:166 (≠ TR 165:166) binding acetyl-CoA
R180 (= R180) binding acetyl-CoA
R183 (≠ K183) binding in other chain

Sites not aligning to the query:

1 modified: Initiator methionine, Removed; Partial

1krrA Galactoside acetyltransferase in complex with acetyl-coenzyme a (see paper)
33% identity, 99% coverage: 1:183/185 of query aligns to 2:182/200 of 1krrA

query
sites
1krrA

M

M

A

P

E

M

S

T

E

E

R

R

V

I

K

R

M

-

V

-

A

A

G

G

E

K

W

L

Y

F

T

T

C

D

I

M

D

C

D

E

E

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L

E

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S

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R

R

G

L

I

R

A

G

R

K

D

T

A

L

V

M

F

Y

E

E

H

F

N

N

L

H

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H

P

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R

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Q

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R

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G

E

N

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L

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K

A

E

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M

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A

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E

G

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A

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I

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E

E

A

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P

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F

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C

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A

S

Y

Y

G

G

F

S

N

N

I

I

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H

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G

D

R

G

N

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F

F

Y

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N

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D

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x
I

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x
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P

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x
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H

H

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H

A

H

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K

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N

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M

I

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A

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P

I

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E

T

I

I

G

G

A

N

N

N

A

V

W

W

I

I

G
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G

G
x
S

S

H

A

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V

V

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I

L
x
N

G

P

G

G

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V

S

T

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G

E

D

G

N

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S

I

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V

I

G
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G

A
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A

G

G

A

S

V

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V

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T

T

R

K

D

D

V

I

A

P

N

N

A

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V

A

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x
A

G

G

N

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P
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P

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K
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R

binding acetyl coenzyme *a: N84 (= N85), I103 (≠ L104), A104 (≠ G105), P105 (= P106), T112 (≠ A113), H114 (= H115), G140 (= G141), S141 (≠ G142), N146 (≠ L147), G158 (= G159), A159 (= A160), A174 (≠ I175), P177 (= P178), R182 (≠ K183)

3ectA Crystal structure of the hexapeptide-repeat containing- acetyltransferase vca0836 from vibrio cholerae
38% identity, 88% coverage: 21:183/185 of query aligns to 12:172/176 of 3ectA

query
sites
3ectA

E

E

L

I

E

E

S

A

L

L

R

R

G

S

I

Q

A

A

R

G

D

R

A

L

V

K

F

L

E

E

H

I

N

N

L

Q

-

S

L

L

P

D

P

E

R

A

Q

E

R

R

G

Y

N

A

L

L

G

Q

P

-

G

-

L

-

K

R

A

E

L

L

L

F

G

G

R

H

A

L

G

G

E

H

G

K

A

S

R

C

I

V

E

Q

A

P

P

P

F

F

H

H

C

C

A

E

Y

F

G

G

F

K

N

T

I

I

F

R

L

I

G

G

D

D

G

H

V

T

F

F

L

I

N

N

A

M

G

N

C

V

T

V

I

M

L

L

D

D

T

G

A

A

S

P

V

I

R

T

I

I

G

G

K

D

A

H

T

V

L

L

L

I

G

G

P

P

N

S

V

T

Q

Q

I

F

Y

Y

C

T

A

A

E

S

H

H

H

S

K

L

E

D

A

Y

S

R

G

R

R

R

Q

Q

A

A

G

W

L

E

E

T

I

I

A

C

R

K

P

P

I

I

E

V

I

I

G

E

A

D

N

D

A

V

W

W

I

I

G

G

S

N

A

V

V

V

I

I

L

N

G

Q

G
|
G

V

V

S

T

I

I

G

G

E

A

G

R

A

S

I

V

V

V

G

A

A

A

G

N

A

S

V

V

T

N

R

Q

D
|
D

V

V

A

P

N

D

A

T

T

L

V

V

I

G

G

G

N

T

P

P

A

A

R

R

P

I

V

L

K

R

binding calcium ion: G138 (= G149), D156 (= D167)

4mzuF Crystal structure of fdtd, a bifunctional ketoisomerase/n- acetyltransferase from shewanella denitrificans (see paper)
38% identity, 57% coverage: 75:180/185 of query aligns to 46:139/294 of 4mzuF

query
sites
4mzuF

N

D

I

V

F

V

L

I

G

G

D

D

G

N

V

V

F

T

L

I

N

K

A

S

G

G

C

V

T

Q

I

I

L

W

D

D

T

-

A

-

S

G

V

I

R

H

I

I

G

Q

K

D

A

D

T

V

L

F

L

I

G

G

P

P

N

N

V

V

Q

T

I

F

Y

-

C

-

A

-

E

-

H

-

K

-

E

-

A

T

S
x
N

G
x
D

R
x
K

Q

Q

A

P

G

R

L

S

E

K

I

I

A

K

R

T

P

I

I

V

E

K

I

K

G

G

A

A

N

S

A

-

W

-

I

I

G
|
G

G
x
A

S

N

A

S

V

T

I

I

L
|
L

G

P

G

G

V

I

S

L

I

I

G

G

E

E

G

N

A

A

I

M

V

V

G
|
G

A
|
A

G

G

A

A

V

V

V

I

T
|
T

R
x
K

D

N

V

V

A

P

A

D

N

N

A

A

T

I

V

V

I
|
I

G

G

N
|
N

P

P

A

G

R
|
R

binding coenzyme a: N81 (≠ S120), D82 (≠ G121), K83 (≠ R122), G100 (= G141), A101 (≠ G142), L106 (= L147), G118 (= G159), A119 (= A160), T124 (= T165), K125 (≠ R166), I134 (= I175), N136 (= N177), R139 (= R180)

Sites not aligning to the query:

binding thymine: 20, 21, 38
binding thymidine-5'-diphosphate: 189, 203, 205, 270

4mzuB Crystal structure of fdtd, a bifunctional ketoisomerase/n- acetyltransferase from shewanella denitrificans (see paper)
37% identity, 57% coverage: 75:180/185 of query aligns to 46:138/290 of 4mzuB

query
sites
4mzuB

N

D

I

V

F

V

L

I

G

G

D

D

G

N

V

V

F

T

L

I

N

K

A

S

G
|
G

C

V

T

Q

I

I

L

W

D

D

T

-

A

-

S

G

V

I

R

H

I

I

G

Q

K

D

A

D

T

V

L
x
F

L

I

G

G

P

P

N
|
N

V

V

Q

T

I

F

Y

-

C

-

A

-

E

-

H

-

H
x
T

K
x
N

E
x
D

A
x
K

S

Q

G
x
P

R

R

Q

S

A

L

G

K

L

T

E

I

I

V

A

K

R

K

P

G

I

A

E

S

I

I

G
|
G

A
|
A

N

N

A

S

W

-

I

-

G

-

S

-

A

-

V

T

I

I

L

L

G

P

G

G

V

I

S

L

I

I

G

G

E

E

G

N

A

A

I

M

V

V

G
|
G

A
|
A

G

G

A

A

V

V

V

I

T
|
T

R
x
K

D

N

V

V

A

P

A

D

N

N

A

A

T

I

V

V

I
|
I

G

G

N

N

P

P

A

G

R
|
R

binding coenzyme a: F72 (≠ L103), T80 (≠ H116), N81 (≠ K117), D82 (≠ E118), K83 (≠ A119), P85 (≠ G121), G99 (= G135), A100 (= A136), G117 (= G159), A118 (= A160), T123 (= T165), K124 (≠ R166), I133 (= I175), R138 (= R180)
binding magnesium ion: G58 (= G87), N76 (= N107)

Sites not aligning to the query:

binding coenzyme a: 199
binding thymine: 20, 21, 38, 39
binding thymidine-5'-diphosphate: 171, 176, 189, 191, 202, 203, 270

A1ADJ6 Polysialic acid O-acetyltransferase; Capsule O-acetyl transferase; EC 2.3.1.136 from Escherichia coli O1:K1 / APEC (see paper)
27% identity, 70% coverage: 57:185/185 of query aligns to 150:280/307 of A1ADJ6

query
sites
A1ADJ6

R

R

A

I

G

H

E

K

G

N

A

S

R

K

I

I

E

K

A

G

P

D

F

I

H

V

C

A

A

T

Y

K

G

G

F

S

N

K

I

V

F

I

L

I

G

G

D

R

G

R

V

T

F

T

L

I

N

G

A

A

G

G

C

F

T

E

I

V

L

V

-

T

D

D

T

K

A

C

S

N

V

V

R

T

I

I

G

G

K

H

A

D

T

C

L

M

L

I

G

A

P

R

N

D

V

V

Q

I

I

L

Y

R

C

A

A

S

E

D

H

G

H
|
H

K

P

E

I

A

F

S

D

-

I

G

H

R

S

Q

K

A

K

G

R

L

I

E

N

I

W

A

A

R

K

P

D

I

I

E

I

I

I

G

S

A

S

N

Y

A

V

W
|
W

I

V

G

G

G

R

S

N

A

V

V

S

I

I

L

M

G

K

G

G

V

V

S

S

I

V

G

G

E

S

G

G

A

S

I

V

V

I

G

G

A

Y

G

G

A

S

V

I

V

V

T

T

R

K

D

D

V

V

A

P

A

S

N

M

A

C

T

A

V

A

I

A

G

G

N

N

P

P

A

A

R

K

P

I

V

I

K

K

R

R

G

N

H210 (= H116) mutation to A: Loss of activity.
W234 (= W139) mutation to A: Loss of activity.

8j40A Crystal structure of catb8 in complex with chloramphenicol (see paper)
45% identity, 28% coverage: 134:184/185 of query aligns to 112:162/209 of 8j40A

query
sites
8j40A

I

I

G

G

A

N

N

D

A

V

W
|
W

I

I

G

G

G

S

S

E

A

A

V

M

I

I

L

M

G

P

G

G

V

I

S

K

I

I

G

G

E

D

G

G

A

A

I
x
V

V

I

G

G

A
x
S

G

R

A

S

V

L

V

V

T

T

R

K

D

D

V

V

A

E

A

P

N

Y

A

A

T

I

V

I

I

G

G

G

N

N

P

P

A

A

R

K

P

Q

V

I

K

K

R

K

binding chloramphenicol: W117 (= W139), V135 (≠ I157), S138 (≠ A160)

Sites not aligning to the query:

binding chloramphenicol: 7, 8, 9, 29, 31, 47, 50, 90, 187, 190, 191, 202, 203, 206

4husA Crystal structure of streptogramin group a antibiotic acetyltransferase vata from staphylococcus aureus in complex with virginiamycin m1 (see paper)
49% identity, 29% coverage: 132:184/185 of query aligns to 113:165/212 of 4husA

query
sites
4husA

I

I

E

E

I

I

G

G

A

N

N

D

A

V

W

W

I

I

G

G

G

R

S

D

A

V

V

T

I

I

L

M

G

P

G

G

V

V

S

K

I

I

G

G

E

D

G

G

A

A

I

I

V

I

G

A

A

A

G

E

A

A

V

V

T

T

R

K

D

N

V

V

A

A

A

P

N

Y

A

S

T

I

V

V

I

G

G

G

N

N

P

P

A

L

R

K

P

F

V

I

K

R

R

K

Sites not aligning to the query:

binding virginiamycin m1: 17, 36, 38

4hurA Crystal structure of streptogramin group a antibiotic acetyltransferase vata from staphylococcus aureus in complex with acetyl coenzyme a (see paper)
49% identity, 29% coverage: 132:184/185 of query aligns to 113:165/211 of 4hurA

query
sites
4hurA

I

I

E

E

I

I

G

G

A

N

N

D

A

V

W
|
W

I
|
I

G
|
G

G
x
R

S

D

A

V

V

T

I

I

L
x
M

G

P

G

G

V

V

S

K

I

I

G

G

E

D

G

G

A

A

I

I

V

I

G
x
A

A
|
A

G

E

A

A

V

V

T
|
T

R

K

D

N

V

V

A

A

A

P

N

Y

A

S

T

I

V

V

I
x
G

G

G

N

N

P
|
P

A

L

R

K

P

F

V
x
I

K
x
R

R

K

binding acetyl coenzyme *a: W120 (= W139), I121 (= I140), G122 (= G141), R123 (≠ G142), M128 (≠ L147), A140 (≠ G159), A141 (= A160), T146 (= T165), G156 (≠ I175), P159 (= P178), I163 (≠ V182), R164 (≠ K183)

Sites not aligning to the query:

binding acetyl coenzyme *a: 51, 67, 68, 69, 79, 80, 110

8vr6A Crystal structure of the pcryo_0619 n-acetryltransferase from psychrobacter cryohalolentis k5 in the presence of coa-disulfide
30% identity, 50% coverage: 87:179/185 of query aligns to 48:165/177 of 8vr6A

query
sites
8vr6A

G

G

C

T

T

S

I

I

L

Y

D

D

T

S

A

S

-

I

-

V

-

L

-

G

S

E

V

V

R

K

I

V

G

G

K

K

A

D

T

T

L

W

L

I

G

G

P

P

N

N

-

T

-

I

-

L

-

D

-

G

-

S

-

G

-

L

-

I

-

G

-

S

-

N

-

C

-

S

-

I

-

S

-

A

-

G

V

V

Q

Q

I

I

Y
|
Y

C

T

A
x
H

E
x
D

H
x
T

-

V

H

R

K

K

E

S

A

L

S

S

G

G

R

G

Q

K

A

A

G

D

L

I

E

D

I

K

A

A

R

S

P

T

I

-

E

R

I

I

G

G

A

S

N

D

A

C

W

Y

I

L

G

G

G

P

S

N

A

T

V

I

I

I

L
x
V

G

K

G

G

V

V

S

K

I

I

G

G

E

D

G

R

A

V

I

V

V

V

G

G

A

A

G

N

A

S

V
x
L

V

V

T
x
L

R

K

D

D

V

I

A

P

A

S

N

D

A

C

T

K

V

V

I

F

G

G

N
x
S

P
|
P

A

A

binding [[(2~{S},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(3~{R})-4-[[3-[2-[2-[3-[[(2~{R})-4-[[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-3,3-dimethyl-2-oxidanyl-butanoyl]amino]propanoylamino]ethyldisulfanyl]ethylamino]-3-oxidanylidene-propyl]amino]-2,2-dimethyl-3-oxidanyl-4-oxidanylidene-butyl] hydrogen phosphate: Y97 (= Y111), H99 (≠ A113), D100 (≠ E114), T101 (≠ H115), V133 (≠ L147), L149 (≠ V163), L151 (≠ T165), S163 (≠ N177), P164 (= P178)

4n6bA Soybean serine acetyltransferase complexed with coa (see paper)
43% identity, 50% coverage: 90:182/185 of query aligns to 147:233/233 of 4n6bA

query
sites
4n6bA

I

L

L

F

D

D

T
x
H

A

A

S

T

-

G

V

V

R

V

I

V

G

G

K

E

A

T

T

A

L

V

L

I

G

G

P

N

N

N

V

V

Q

S

I

I

Y
x
L

C

-

A

-

E

-

H

H

K

V

E

T

A

L

S

G

G
|
G

R

T

Q

G

A

G

G

D

L

-

E

-

I

-

A

-

R

R

P

H

I

P

E

K

I

I

G

G

A

D

N

G

A

V

W

L

I

I

G

G

G

A

S

G

A

A

V

T

I

I

L

L

G

G

G

N

V

I

S

K

I

I

G

G

E

E

G

G

A

A

I
x
K

V

V

G
|
G

A
|
A

G

G

A

S

V

V

T
x
L

R

I

D

D

V

V

A

P

N

R

A

T

T

T

V

A

I
x
V

G

G

N

N

P

P

A

A

R

R

P

L

V

V

binding coenzyme a: H150 (≠ T93), L169 (≠ Y111), G176 (= G121), K208 (≠ I157), G210 (= G159), A211 (= A160), L216 (≠ T165), V226 (≠ I175)

6x3jA Crystal structure of streptogramin a acetyltransferase vata from staphylococcus aureus in complex with streptogramin analog f0224 (46) (see paper)
49% identity, 29% coverage: 132:184/185 of query aligns to 113:165/206 of 6x3jA

query
sites
6x3jA

I

I

E

E

I

I

G

G

A

N

N

D

A

V

W
|
W

I

I

G
|
G

G

R

S

D

A

V

V

T

I

I

L

M

G

P

G

G

V

V

S

K

I

I

G

G

E

D

G

G

A

A

I

I

V

I

G

A

A

A

G

E

A

A

V

V

T

T

R

K

D

N

V

V

A

A

A

P

N

Y

A

S

T

I

V

V

I

G

G

G

N

N

P

P

A

L

R

K

P

F

V

I

K

R

R

K

binding thioacetic acid s-{2-[3-(2-hydroxy-3,3-dimethyl-4-phosphonooxy-butyrylamino)-propionylamino]-ethyl} ester: W120 (= W139), G122 (= G141)

Sites not aligning to the query:

4n69A Soybean serine acetyltransferase complexed with serine (see paper)
43% identity, 50% coverage: 90:182/185 of query aligns to 154:243/243 of 4n69A

query
sites
4n69A

I

L

L

F

D

D

T

H

A

A

S

T

-

G

V

V

R

V

I

V

G

G

K

E

A

T

T

A

L

V

L

I

G

G

P

N

N

N

V

V

Q

S

I

I

Y

L

C

-

A

-

E

-

H

H

K

V

E

T

-

L

-

G

A
x
G

S

T

G

G

R

K

Q

V

A

G

G

G

L

-

E

-

I

-

A

D

R
|
R

P
x
H

I

P

E

K

I

I

G

G

A

D

N

G

A

V

W

L

I

I

G

G

G

A

S

G

A

A

V

T

I

I

L

L

G

G

G

N

V

I

S

K

I

I

G

G

E

E

G

G

A

A

I

K

V

V

G

G

A

A

G

G

A

S

V

V

T

L

R

I

D

D

V

V

A

P

N

R

A

T

T

T

V

A

I

V

G

G

N

N

P

P

A

A

R

R

P

L

V

V

binding serine: G183 (≠ A119), R191 (= R130), H192 (≠ P131)

Query Sequence

>WP_013529945.1 NCBI__GCF_000185905.1:WP_013529945.1
MAESERVKMVAGEWYTCIDDELESLRGIARDAVFEHNLLPPRQRGNLGPGLKALLGRAGE
GARIEAPFHCAYGFNIFLGDGVFLNAGCTILDTASVRIGKATLLGPNVQIYCAEHHKEAS
GRQAGLEIARPIEIGANAWIGGSAVILGGVSIGEGAIVGAGAVVTRDVAANATVIGNPAR
PVKRG

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory