SitesBLAST

P15474 3-dehydroquinate dehydratase; 3-dehydroquinase; Type II DHQase; EC 4.2.1.10 from Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) (see 2 papers)
57% identity, 97% coverage: 4:142/144 of query aligns to 10:148/157 of P15474

query
sites
P15474

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R24 (= R18) mutation to A: Reduces kcat 30000-fold. Reduces KM for 3-dehydroquinate 6-fold.; mutation to K: Reduces kcat 2700-fold. Reduces KM for 3-dehydroquinate 4-fold.; mutation to Q: Reduces kcat 3100-fold. Reduces KM for 3-dehydroquinate 8-fold.

Sites not aligning to the query:

1 modified: Initiator methionine, Removed

1v1jA Crystal structure of type ii dehydroquintae dehydratase from streptomyces coelicolor in complex with 3-fluoro (see paper)
57% identity, 97% coverage: 4:142/144 of query aligns to 9:147/150 of 1v1jA

query
sites
1v1jA

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active site: P15 (= P10), N16 (= N11), R23 (= R18), Y28 (= Y23), N79 (= N74), A82 (= A77), E104 (= E99), H106 (= H101), R113 (= R108)
binding 2-anhydro-3-fluoro-quinic acid: Y28 (= Y23), N79 (= N74), A81 (≠ G76), A82 (= A77), H85 (= H80), H106 (= H101), I107 (≠ L102), S108 (= S103), R117 (= R112)

1gtzA Structure of streptomyces coelicolor type ii dehydroquinase r23a mutant in complex with dehydroshikimate (see paper)
56% identity, 97% coverage: 4:142/144 of query aligns to 8:146/149 of 1gtzA

query
sites
1gtzA

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active site: P14 (= P10), N15 (= N11), A22 (≠ R18), Y27 (= Y23), N78 (= N74), A81 (= A77), E103 (= E99), H105 (= H101), R112 (= R108)
binding 3-dehydroshikimate: Y27 (= Y23), A80 (≠ G76), A81 (= A77), H84 (= H80), H105 (= H101), I106 (≠ L102), S107 (= S103), R116 (= R112)

8idrC Crystal structure of apo-form of dehydroquinate dehydratase from corynebacterium glutamicum (see paper)
49% identity, 96% coverage: 4:141/144 of query aligns to 4:140/147 of 8idrC

query
sites
8idrC

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binding citrate anion: N74 (= N74), G76 (= G76), H100 (= H101), I101 (≠ L102), S102 (= S103)

Q48255 3-dehydroquinate dehydratase; 3-dehydroquinase; Type II DHQase; EC 4.2.1.10 from Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) (see paper)
51% identity, 95% coverage: 4:140/144 of query aligns to 3:141/167 of Q48255

query
sites
Q48255

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N76 (= N74) binding substrate
H82 (= H80) binding substrate
D89 (= D87) binding substrate
R113 (= R112) binding substrate

4b6sA Structure of helicobacter pylori type ii dehydroquinase inhibited by (2s)-2-perfluorobenzyl-3-dehydroquinic acid (see paper)
51% identity, 95% coverage: 4:140/144 of query aligns to 3:141/158 of 4b6sA

query
sites
4b6sA

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active site: P9 (= P10), N10 (= N11), R17 (= R18), Y22 (= Y23), N76 (= N74), A79 (= A77), E100 (= E99), H102 (= H101), R109 (= R108)
binding (1R,2S,4S,5R)-2-(2,3,4,5,6-pentafluorophenyl)methyl-1,4,5-trihydroxy-3-oxocyclohexane-1-carboxylic acid: N10 (= N11), L14 (= L15), Y22 (= Y23), N76 (= N74), G78 (= G76), A79 (= A77), H82 (= H80), H102 (= H101), L103 (= L102), T104 (≠ S103), R113 (= R112)

2xb9A Structure of helicobacter pylori type ii dehydroquinase in complex with inhibitor compound (2r)-2-(4-methoxybenzyl)-3-dehydroquinic acid (see paper)
51% identity, 95% coverage: 4:140/144 of query aligns to 3:141/158 of 2xb9A

query
sites
2xb9A

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active site: P9 (= P10), N10 (= N11), R17 (= R18), Y22 (= Y23), N76 (= N74), A79 (= A77), E100 (= E99), H102 (= H101), R109 (= R108)
binding (1r,2r,4s,5r)-1,4,5-trihydroxy-2-(4-methoxybenzyl)-3-oxocyclohexanecarboxylic acid: N10 (= N11), Y22 (= Y23), N76 (= N74), A79 (= A77), H82 (= H80), H102 (= H101), L103 (= L102), T104 (≠ S103), R113 (= R112)

1j2yA Crystal structure of the type ii 3-dehydroquinase (see paper)
51% identity, 95% coverage: 4:140/144 of query aligns to 3:141/158 of 1j2yA

query
sites
1j2yA

V

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V

H
|
H

L
|
L

S
x
T

N

N

I

I

H

Q

A

A

R
|
R

E

E

P

E

F

F

R
|
R

H

K

V

N

S

S

M

Y

V

T

A

G

P

A

V

A

A

C

V

G

G

G

M

V

I

I

C

M

G

G

F

F

G

G

P

P

L

L

G

G

Y

Y

T

N

L

M

A

A

L

L

Q

M

A

A

L

M

active site: P9 (= P10), N10 (= N11), R17 (= R18), Y22 (= Y23), N76 (= N74), A79 (= A77), E100 (= E99), H102 (= H101), R109 (= R108)
binding 1,3,4-trihydroxy-5-oxo-cyclohexanecarboxylic acid: Y22 (= Y23), N76 (= N74), G78 (= G76), H82 (= H80), H102 (= H101), L103 (= L102), T104 (≠ S103), R113 (= R112)

4b6rA Structure of helicobacter pylori type ii dehydroquinase inhibited by (2s)-2-(4-methoxy)benzyl-3-dehydroquinic acid (see paper)
51% identity, 95% coverage: 4:140/144 of query aligns to 3:141/157 of 4b6rA

query
sites
4b6rA

V

I

F

L

V

V

L

I

N

Q

G

G

P
|
P

N
|
N

L

L

N

N

A

M

L

L

G

G

K

H

R
|
R

E

D

P

P

G

R

I

L

Y
|
Y

G

G

G

M

K

V

T

T

L

L

A

D

A

Q

I

I

A

H

D

E

-

I

-

M

-

Q

-

T

D

F

C

V

K

K

Q

Q

A

G

G

N

T

-

A

-

L

L

G

D

F

V

E

E

I

L

D

E

F

F

R

F

Q

Q

S

T

N

N

H

F

E

E

G

G

D

E

L

I

V

I

D

D

W

K

I

I

Q

Q

E

E

A

S

-

V

G

G

D

S

K

D

A

Y

V

E

G

G

I

I

V

I

I

I

N
|
N

P

P

G
|
G

A
|
A

Y

F

S

S

H
|
H

T

T

S

S

I

I

A

A

I

I

H

A

D
|
D

A

A

I

I

R

-

A

M

V
x
L

A

A

P

G

L

K

P

P

V

V

A

I

E
|
E

V

V

H
|
H

L
|
L

S
x
T

N

N

I

I

H

Q

A

A

R
|
R

E

E

P

E

F

F

R
|
R

H

K

V

N

S

S

M

Y

V

T

A

G

P

A

V

A

A

C

V

G

G

G

M

V

I

I

C

M

G

G

F

F

G

G

P

P

L

L

G

G

Y

Y

T

N

L

M

A

A

L

L

Q

M

A

A

L

M

active site: P9 (= P10), N10 (= N11), R17 (= R18), Y22 (= Y23), N76 (= N74), A79 (= A77), E100 (= E99), H102 (= H101), R109 (= R108)
binding (1R,2S,4S,5R)-2-(4-methoxyphenyl)methyl-1,4,5-trihydroxy-3-oxocyclohexane-1-carboxylic acid: Y22 (= Y23), N76 (= N74), G78 (= G76), A79 (= A77), H82 (= H80), D89 (= D87), L93 (≠ V92), H102 (= H101), L103 (= L102), T104 (≠ S103), R113 (= R112)

2c4wA Type ii dehydroquinase from h. Pylori in complex with ah9095 (see paper)
51% identity, 95% coverage: 4:140/144 of query aligns to 12:150/168 of 2c4wA

query
sites
2c4wA

V

I

F

L

V

V

L

I

N

Q

G

G

P
|
P

N
|
N

L
|
L

N

N

A

M

L
|
L

G

G

K

H

R
|
R

E
x
D

P

P

G

R

I

L

Y
|
Y

G

G

G

M

K

V

T

T

L

L

A

D

A

Q

I

I

A

H

D

E

D

I

-

M

-

Q

-

T

-

F

C

V

K

K

Q

Q

A

G

G

N

T

-

A

-

L

L

G

D

F

V

E

E

I

L

D

E

F

F

R

F

Q

Q

S

T

N

N

H

F

E

E

G

G

D

E

L

I

V

I

D

D

W

K

I

I

Q

Q

E

E

A

S

-

V

G

G

D

S

K

E

A

Y

V

E

G

G

I

I

V

I

I

I

N
|
N

P

P

G
|
G

A
|
A

Y

F

S

S

H
|
H

T

T

S

S

I

I

A

A

I

I

H

A

D

D

A

A

I

I

R

-

A

M

V

L

A

A

P

G

L

K

P

P

V

V

A

I

E
|
E

V

V

H
|
H

L
|
L

S
x
T

N

N

I
|
I

H

Q

A

A

R
|
R

E

E

P

E

F

F

R
|
R

H

K

V

N

S

S

M

Y

V

T

A

G

P

A

V

A

A

C

V

G

G

G

M

V

I

I

C

M

G

G

F

F

G

G

P

P

L

L

G

G

Y

Y

T

N

L

M

A

A

L

L

Q

M

A

A

L

M

active site: P18 (= P10), N19 (= N11), R26 (= R18), Y31 (= Y23), N85 (= N74), A88 (= A77), E109 (= E99), H111 (= H101), R118 (= R108)
binding n-tetrazol-5-yl 9-oxo-9h-xanthene-2 sulphonamide: L20 (= L12), L23 (= L15), D27 (≠ E19), G87 (= G76), H91 (= H80), H111 (= H101), L112 (= L102), T113 (≠ S103), I115 (= I105), R122 (= R112)

2xd9A Structure of helicobacter pylori type ii dehydroquinase in complex with inhibitor compound (4r,6r,7s)-4,6,7-trihydroxy-2-((e)-prop-1- enyl)-4,5,6,7-tetrahydrobenzo(b)thiophene-4-carboxylic acid (see paper)
51% identity, 95% coverage: 4:140/144 of query aligns to 3:141/153 of 2xd9A

query
sites
2xd9A

V

I

F

L

V

V

L

I

N

Q

G

G

P
|
P

N
|
N

L

L

N

N

A

M

L
|
L

G

G

K

H

R
|
R

E

D

P

P

G

R

I

L

Y
|
Y

G

G

G

M

K

V

T

T

L

L

A

D

A

Q

I

I

A

H

D

E

-

I

-

M

-

Q

-

T

D

F

C

V

K

K

Q

Q

A

G

G

N

T

-

A

-

L

L

G

D

F

V

E

E

I

L

D

E

F

F

R

F

Q

Q

S

T

N

N

H

F

E

E

G

G

D

E

L

I

V

I

D

D

W

K

I

I

Q

Q

E

E

A

S

-

V

G

G

D

S

K

D

A

Y

V

E

G

G

I

I

V

I

I

I

N
|
N

P

P

G
|
G

A
|
A

Y

F

S

S

H
|
H

T

T

S

S

I

I

A

A

I

I

H

A

D

D

A

A

I

I

R

-

A

M

V

L

A

A

P

G

L

K

P

P

V

V

A

I

E
|
E

V

V

H
|
H

L
|
L

S
x
T

N

N

I

I

H

Q

A

A

R
|
R

E

E

P

E

F

F

R
|
R

H

K

V

N

S

S

M

Y

V

T

A

G

P

A

V

A

A

C

V

G

G

G

M

V

I

I

C

M

G

G

F

F

G

G

P

P

L

L

G

G

Y

Y

T

N

L

M

A

A

L

L

Q

M

A

A

L

M

active site: P9 (= P10), N10 (= N11), R17 (= R18), Y22 (= Y23), N76 (= N74), A79 (= A77), E100 (= E99), H102 (= H101), R109 (= R108)
binding (4r,6r,7s)-4,6,7-trihydroxy-2-[(1e)-prop-1-en-1-yl]-4,5,6,7-tetrahydro-1-benzothiophene-4-carboxylic acid: N10 (= N11), L14 (= L15), Y22 (= Y23), N76 (= N74), G78 (= G76), A79 (= A77), H82 (= H80), H102 (= H101), L103 (= L102), T104 (≠ S103), R113 (= R112)

2wksA Structure of helicobacter pylori type ii dehydroquinase with a new carbasugar-thiophene inhibitor. (see paper)
51% identity, 95% coverage: 4:140/144 of query aligns to 3:141/153 of 2wksA

query
sites
2wksA

V

I

F

L

V

V

L

I

N

Q

G

G

P
|
P

N
|
N

L
|
L

N

N

A

M

L

L

G

G

K

H

R
|
R

E

D

P

P

G

R

I

L

Y
|
Y

G

G

G

M

K

V

T

T

L

L

A

D

A

Q

I

I

A

H

D

E

-

I

-

M

-

Q

-

T

D

F

C

V

K

K

Q

Q

A

G

G

N

T

-

A

-

L

L

G

D

F

V

E

E

I

L

D

E

F

F

R

F

Q

Q

S

T

N

N

H

F

E

E

G

G

D

E

L

I

V

I

D

D

W

K

I

I

Q

Q

E

E

A

S

-

V

G

G

D

S

K

D

A

Y

V

E

G

G

I

I

V

I

I

I

N
|
N

P

P

G
|
G

A
|
A

Y

F

S

S

H
|
H

T

T

S

S

I

I

A

A

I

I

H

A

D

D

A

A

I

I

R

-

A

M

V

L

A

A

P

G

L

K

P

P

V

V

A

I

E
|
E

V

V

H
|
H

L
|
L

S
x
T

N

N

I

I

H

Q

A

A

R
|
R

E

E

P

E

F

F

R
|
R

H

K

V

N

S

S

M

Y

V

T

A

G

P

A

V

A

A

C

V

G

G

G

M

V

I

I

C

M

G

G

F

F

G

G

P

P

L

L

G

G

Y

Y

T

N

L

M

A

A

L

L

Q

M

A

A

L

M

active site: P9 (= P10), N10 (= N11), R17 (= R18), Y22 (= Y23), N76 (= N74), A79 (= A77), E100 (= E99), H102 (= H101), R109 (= R108)
binding (1R,4S,5R)-1,4,5-trihydroxy-3-[(5-methyl-1-benzothiophen-2-yl)methoxy]cyclohex-2-ene-1-carboxylic acid: L11 (= L12), Y22 (= Y23), N76 (= N74), G78 (= G76), A79 (= A77), H82 (= H80), H102 (= H101), L103 (= L102), T104 (≠ S103), R113 (= R112)

2xdaA Structure of helicobacter pylori type ii dehydroquinase in complex with inhibitor compound (4r,6r,7s)-2-(2-cyclopropyl)ethyl-4,6,7- trihydroxy-4,5,6,7-tetrahydrobenzo(b)thiophene-4-carboxylic acid (see paper)
51% identity, 95% coverage: 4:140/144 of query aligns to 3:141/150 of 2xdaA

query
sites
2xdaA

V

I

F

L

V

V

L

I

N

Q

G

G

P
|
P

N
|
N

L
|
L

N

N

A
x
M

L

L

G

G

K

H

R
|
R

E

D

P

P

G

R

I

L

Y
|
Y

G

G

G

M

K

V

T

T

L

L

A

D

A

Q

I

I

A

H

D

E

D

I

-

M

-

Q

-

T

-

F

C

V

K

K

Q

Q

A

G

G

N

T

-

A

-

L

L

G

D

F

V

E

E

I

L

D

E

F

F

R

F

Q

Q

S

T

N

N

H

F

E

E

G

G

D

E

L

I

V

I

D

D

W

K

I

I

Q

Q

E

E

A

S

-

V

G

G

D

S

K

D

A

Y

V

E

G

G

I

I

V

I

I

I

N
|
N

P

P

G

G

A
|
A

Y

F

S

S

H
|
H

T

T

S

S

I

I

A

A

I

I

H

A

D

D

A

A

I

I

R

-

A

M

V

L

A

A

P

G

L

K

P

P

V

V

A

I

E
|
E

V

V

H
|
H

L
|
L

S
x
T

N

N

I

I

H

Q

A

A

R
|
R

E

E

P

E

F

F

R
|
R

H

K

V

N

S

S

M

Y

V

T

A

G

P

A

V

A

A

C

V

G

G

G

M

V

I

I

C

M

G

G

F

F

G

G

P

P

L

L

G

G

Y

Y

T

N

L

M

A

A

L

L

Q

M

A

A

L

M

active site: P9 (= P10), N10 (= N11), R17 (= R18), Y22 (= Y23), N76 (= N74), A79 (= A77), E100 (= E99), H102 (= H101), R109 (= R108)
binding (4r,6r,7s)-2-(2-cyclopropylethyl)-4,6,7-trihydroxy-4,5,6,7-tetrahydro-1-benzothiophene-4-carboxylic acid: N10 (= N11), L11 (= L12), M13 (≠ A14), Y22 (= Y23), N76 (= N74), A79 (= A77), H82 (= H80), H102 (= H101), L103 (= L102), T104 (≠ S103), R113 (= R112)

4cl0A Structure of the mycobacterium tuberculosis type ii dehydroquinase inhibited by a 3-dehydroquinic acid derivative
46% identity, 96% coverage: 4:141/144 of query aligns to 3:139/140 of 4cl0A

query
sites
4cl0A

V

V

F

N

V

V

L

I

N

N

G

G

P
|
P

N
|
N

L

L

N

G

A

R

L

L

G

G

K

R

R
|
R

E

E

P

P

G

A

I

V

Y
|
Y

G

G

K

T

T

T

L

H

A

D

A

E

I

L

A

V

D

A

D

L

C

I

K

E

Q

R

A

E

G

A

T

A

A

E

L

L

G

G

F

L

E

K

I

A

D

V

F

V

R

R

Q

Q

S

S

N

D

H

S

E

E

G

A

D

Q

L

L

V

L

D

D

W

W

I

I

Q

H

E

Q

A

A

G

A

D

D

K

A

A

A

V

E

G

P

I

V

V

I

I

L

N
|
N

P

A

G
|
G

A
x
G

Y

L

S

T

H
|
H

T

T

S

S

I

V

A

A

I

L

H

R

D

D

A

A

I

C

R

A

A

E

V

L

A

S

P

A

L

-

P

P

V

L

A

I

E
|
E

V

V

H
|
H

L
x
I

S
|
S

N

N

I

V

H

H

A

A

R
|
R

E

E

P

E

F

F

R
|
R

H

R

V

H

S

S

M

Y

V

L

A

S

P

P

V

I

A

A

V

T

G

G

M

V

I

I

C

V

G

G

F

L

G

G

P

I

L

Q

G

G

Y

Y

T

L

L

L

A

A

L

L

Q

R

A

Y

L

L

A

A

active site: P9 (= P10), N10 (= N11), R17 (= R18), Y22 (= Y23), N73 (= N74), G76 (≠ A77), E97 (= E99), H99 (= H101), R106 (= R108)
binding (2r)-2-methyl-3-dehydroquinic acid: R17 (= R18), Y22 (= Y23), N73 (= N74), G75 (= G76), G76 (≠ A77), H79 (= H80), H99 (= H101), I100 (≠ L102), S101 (= S103), R110 (= R112)

4b6pA Structure of mycobacterium tuberculosis type ii dehydroquinase inhibited by (2s)-2-perfluorobenzyl-3-dehydroquinic acid (see paper)
46% identity, 96% coverage: 4:141/144 of query aligns to 3:139/142 of 4b6pA

query
sites
4b6pA

V

V

F

N

V

V

L

I

N

N

G

G

P
|
P

N
|
N

L

L

N

G

A

R

L
|
L

G

G

K

R

R
|
R

E

E

P

P

G

A

I

V

Y
|
Y

G

G

K

T

T

T

L

H

A

D

A

E

I

L

A

V

D

A

D

L

C

I

K

E

Q

R

A

E

G

A

T

A

A

E

L

L

G

G

F

L

E

K

I

A

D

V

F

V

R

R

Q

Q

S

S

N

D

H

S

E

E

G

A

D

Q

L

L

V

L

D

D

W

W

I

I

Q

H

E

Q

A

A

G

A

D

D

K

A

A

A

V

E

G

P

I

V

V

I

I

L

N
|
N

P

A

G
|
G

A
x
G

Y

L

S

T

H
|
H

T

T

S

S

I

V

A

A

I

L

H

R

D

D

A

A

I

C

R

A

A

E

V

L

A

S

P

A

L

-

P

P

V

L

A

I

E
|
E

V

V

H
|
H

L
x
I

S
|
S

N

N

I

V

H

H

A

A

R
|
R

E

E

P

E

F

F

R
|
R

H

R

V

H

S

S

M

Y

V

L

A

S

P

P

V

I

A

A

V

T

G

G

M

V

I

I

C

V

G

G

F

L

G

G

P

I

L

Q

G

G

Y

Y

T

L

L

L

A

A

L

L

Q

R

A

Y

L

L

A

A

active site: P9 (= P10), N10 (= N11), R17 (= R18), Y22 (= Y23), N73 (= N74), G76 (≠ A77), E97 (= E99), H99 (= H101), R106 (= R108)
binding (1R,2S,4S,5R)-2-(2,3,4,5,6-pentafluorophenyl)methyl-1,4,5-trihydroxy-3-oxocyclohexane-1-carboxylic acid: N10 (= N11), L14 (= L15), R17 (= R18), Y22 (= Y23), N73 (= N74), G75 (= G76), G76 (≠ A77), H79 (= H80), H99 (= H101), I100 (≠ L102), S101 (= S103), R110 (= R112)

3n8kM Type ii dehydroquinase from mycobacterium tuberculosis complexed with citrazinic acid (see paper)
46% identity, 96% coverage: 4:141/144 of query aligns to 12:148/151 of 3n8kM

query
sites
3n8kM

V

V

F

N

V

V

L

I

N

N

G

G

P
|
P

N
|
N

L

L

N

G

A

R

L

L

G

G

K

R

R
|
R

E

E

P

P

G

A

I

V

Y
|
Y

G

G

K

T

T

T

L

H

A

D

A

E

I

L

A

V

D

A

D

L

C

I

K

E

Q

R

A

E

G

A

T

A

A

E

L

L

G

G

F

L

E

K

I

A

D

V

F

V

R

R

Q

Q

S

S

N

D

H

S

E

E

G

A

D

Q

L

L

V

L

D

D

W

W

I

I

Q

H

E

Q

A

A

G

A

D

D

K

A

A

A

V

E

G

P

I

V

V

I

I

L

N
|
N

P

A

G
|
G

A
x
G

Y

L

S

T

H
|
H

T

T

S

S

I

V

A

A

I

L

H

R

D

D

A

A

I

C

R

A

A

E

V

L

A

S

P

A

L

-

P

P

V

L

A

I

E
|
E

V

V

H
|
H

L
x
I

S
|
S

N

N

I

V

H

H

A

A

R
|
R

E

E

P

E

F

F

R
|
R

H

R

V

H

S

S

M

Y

V

L

A

S

P

P

V

I

A

A

V

T

G

G

M

V

I

I

C

V

G

G

F

L

G

G

P

I

L

Q

G

G

Y

Y

T

L

L

L

A

A

L

L

Q

R

A

Y

L

L

A

A

active site: P18 (= P10), N19 (= N11), N82 (= N74), G85 (≠ A77), E106 (= E99), H108 (= H101), R115 (= R108)
binding 2,6-dioxo-1,2,3,6-tetrahydropyridine-4-carboxylic acid: R26 (= R18), Y31 (= Y23), N82 (= N74), G84 (= G76), H88 (= H80), H108 (= H101), I109 (≠ L102), S110 (= S103), R119 (= R112)

3n76A Crystal structure of 3-dehydroquinate dehydratase from mycobacterium tuberculosis in complex with compound 5 (see paper)
46% identity, 96% coverage: 4:141/144 of query aligns to 4:140/143 of 3n76A

query
sites
3n76A

V

V

F

N

V

V

L

I

N

N

G

G

P
|
P

N
|
N

L

L

N

G

A
x
R

L

L

G

G

K

R

R
|
R

E

E

P

P

G

A

I

V

Y
|
Y

G

G

K

T

T

T

L

H

A

D

A

E

I

L

A

V

D

A

D

L

C

I

K

E

Q

R

A

E

G

A

T

A

A

E

L

L

G

G

F

L

E

K

I

A

D

V

F

V

R

R

Q

Q

S

S

N

D

H

S

E

E

G

A

D

Q

L

L

V

L

D

D

W

W

I

I

Q

H

E

Q

A

A

G

A

D

D

K

A

A

A

V

E

G

P

I

V

V

I

I

L

N
|
N

P

A

G
|
G

A
x
G

Y

L

S

T

H
|
H

T

T

S

S

I

V

A

A

I

L

H

R

D

D

A

A

I

C

R

A

A

E

V

L

A

S

P

A

L

-

P

P

V

L

A

I

E
|
E

V

V

H
|
H

L
x
I

S
|
S

N

N

I

V

H

H

A

A

R
|
R

E

E

P

E

F

F

R
|
R

H

R

V

H

S

S

M

Y

V

L

A

S

P

P

V

I

A

A

V

T

G

G

M

V

I

I

C

V

G

G

F

L

G

G

P

I

L

Q

G

G

Y

Y

T

L

L

L

A

A

L

L

Q

R

A

Y

L

L

A

A

active site: P10 (= P10), N11 (= N11), R18 (= R18), Y23 (= Y23), N74 (= N74), G77 (≠ A77), E98 (= E99), H100 (= H101), R107 (= R108)
binding (1s,3r,4r,5s)-1,3,4-trihydroxy-5-(3-phenoxypropyl)cyclohexanecarboxylic acid: N11 (= N11), R14 (≠ A14), R18 (= R18), Y23 (= Y23), N74 (= N74), G76 (= G76), G77 (≠ A77), H80 (= H80), H100 (= H101), I101 (≠ L102), S102 (= S103), R111 (= R112)

Query Sequence

>WP_013531359.1 NCBI__GCF_000185905.1:WP_013531359.1
MKTVFVLNGPNLNALGKREPGIYGGKTLAAIADDCKQAGTALGFEIDFRQSNHEGDLVDW
IQEAGDKAVGIVINPGAYSHTSIAIHDAIRAVAPLPVAEVHLSNIHAREPFRHVSMVAPV
AVGMICGFGPLGYTLALQALAARL

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory