Comparing WP_013537189.1 NCBI__GCF_000185805.1:WP_013537189.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
P9WP55 O-acetylserine sulfhydrylase; OAS sulfhydrylase; OASS; Cysteine synthase A; CSase A; O-acetylserine (thiol)-lyase A; OAS-TL A; O-acetylserine-specific cysteine synthase; Sulfide-dependent cysteine synthase; EC 2.5.1.47 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
51% identity, 97% coverage: 8:302/303 of query aligns to 7:305/310 of P9WP55
2q3dA 2.2 a resolution crystal structure of o-acetylserine sulfhydrylase (oass) from mycobacterium tuberculosis in complex with the reaction intermediate alpha-aminoacrylate (see paper)
51% identity, 97% coverage: 8:302/303 of query aligns to 7:305/306 of 2q3dA
3zeiA Structure of the mycobacterium tuberculosis o-acetylserine sulfhydrylase (oass) cysk1 in complex with a small molecule inhibitor (see paper)
51% identity, 96% coverage: 8:297/303 of query aligns to 7:300/300 of 3zeiA
2q3cA 2.1 a resolution crystal structure of o-acetylserine sulfhydrylase (oass) holoenzyme from mycobacterium tuberculosis in complex with the inhibitory peptide dfsi (see paper)
51% identity, 96% coverage: 8:297/303 of query aligns to 7:300/300 of 2q3cA
4lmaA Crystal structure analysis of o-acetylserine sulfhydrylase cysk1 from microcystis aeruginosa 7806 (see paper)
47% identity, 98% coverage: 8:303/303 of query aligns to 7:309/318 of 4lmaA
6ahiB Crystal structure of o-acetylserine dependent cystathionine beta- synthase from helicobacter pylori. (see paper)
41% identity, 98% coverage: 5:302/303 of query aligns to 4:305/306 of 6ahiB
4lmbA Crystal structure analysis of o-acetylserine sulfhydrylase cysk2 complexed with cystine from microcystis aeruginosa 7806 (see paper)
47% identity, 98% coverage: 8:303/303 of query aligns to 7:309/310 of 4lmbA
5xoqA Crystal structure of o-acetylserine sulfhydrylase with bound transcription factor peptide inhibitor from planctomyces limnophilus
48% identity, 97% coverage: 10:303/303 of query aligns to 10:307/310 of 5xoqA
8b9wA Cysteine synthase from trypanosoma theileri with plp bound (see paper)
48% identity, 96% coverage: 12:302/303 of query aligns to 17:311/329 of 8b9wA
P47999 Cysteine synthase, chloroplastic/chromoplastic; At.OAS.7-4; Beta-substituted Ala synthase 2;1; ARAth-Bsas2;1; CSase B; AtCS-B; CS-B; O-acetylserine (thiol)-lyase; O-acetylserine sulfhydrylase; OAS-TL B; cpACS1; EC 2.5.1.47 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
47% identity, 96% coverage: 12:303/303 of query aligns to 83:379/392 of P47999
Sites not aligning to the query:
5xemA Crystal structure of a hydrogen sulfide-producing enzyme (fn1220) from fusobacterium nucleatum in complex with l-lanthionine-plp schiff base
43% identity, 97% coverage: 6:299/303 of query aligns to 4:302/302 of 5xemA
4aecA Crystal structure of the arabidopsis thaliana o-acetyl-serine-(thiol)- lyasE C (see paper)
46% identity, 96% coverage: 12:303/303 of query aligns to 21:317/323 of 4aecA
7n2tA O-acetylserine sulfhydrylase from citrullus vulgaris in the internal aldimine state, with citrate bound (see paper)
50% identity, 98% coverage: 8:303/303 of query aligns to 7:307/309 of 7n2tA
D2Z027 O-ureido-L-serine synthase; Cysteine synthase homolog DscD; O-acetylserine sulfhydrylase; EC 2.6.99.3; EC 2.5.1.47 from Streptomyces lavendulae (see paper)
45% identity, 99% coverage: 5:303/303 of query aligns to 4:304/324 of D2Z027
3x43A Crystal structure of o-ureido-l-serine synthase (see paper)
45% identity, 99% coverage: 5:303/303 of query aligns to 3:303/316 of 3x43A
5xenA Crystal structure of a hydrogen sulfide-producing enzyme (fn1220) from fusobacterium nucleatum in complex with l-serine-plp schiff base
43% identity, 96% coverage: 6:297/303 of query aligns to 4:300/300 of 5xenA
3x44A Crystal structure of o-ureido-l-serine-bound k43a mutant of o-ureido- l-serine synthase (see paper)
44% identity, 99% coverage: 5:303/303 of query aligns to 3:303/321 of 3x44A
6kr5B Crystal structure of o-acetyl serine sulfhydrylase isoform 3 from entamoeba histolytica (see paper)
42% identity, 100% coverage: 2:303/303 of query aligns to 9:318/336 of 6kr5B
P0ABK5 Cysteine synthase A; CSase A; O-acetylserine (thiol)-lyase A; OAS-TL A; O-acetylserine sulfhydrylase A; S-carboxymethylcysteine synthase; Sulfate starvation-induced protein 5; SSI5; EC 2.5.1.47; EC 4.5.1.5 from Escherichia coli (strain K12) (see 5 papers)
44% identity, 96% coverage: 12:302/303 of query aligns to 12:312/323 of P0ABK5
Sites not aligning to the query:
Q93244 Cysteine synthase 1; O-acetylserine (thiol)-lyase 1; OAS-TL; EC 2.5.1.47 from Caenorhabditis elegans (see 2 papers)
45% identity, 96% coverage: 12:302/303 of query aligns to 15:310/341 of Q93244
>WP_013537189.1 NCBI__GCF_000185805.1:WP_013537189.1
MKTWLSGILDAVGNTPLLRVELGGVEVFLKLESFNPGGSIKDRVAKAIIEEGERSGELTP
DKTVIEATSGNTGIGLAMVCAAKGYRCLIVMPENMSQERKKILRAYGAELLLTPAEEGVA
GAVRRAQELVEREPERFFPARQFENPVNPKVHYEQTALEVLTQLGRLPALFVAGIGTGGT
FTGMARRFKEVNPNCLCVAVEPDTCAPLSGGPVGPHRIQGIGAGFVPKTLDRGLVDRVET
VSYEEAREFTRRLAKEFGVLCGVSTGANLAVAVRVAKDVKPNGPVVTVAPDTGERYLSTD
LFE
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory