SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing WP_013553394.1 NCBI__GCF_000186245.1:WP_013553394.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 12 hits to proteins with known functional sites (download)

P45131 Homoserine O-acetyltransferase; HAT; Homoserine O-trans-acetylase; Homoserine transacetylase; HTA; EC 2.3.1.31 from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) (see 2 papers)
39% identity, 99% coverage: 1:363/368 of query aligns to 1:355/358 of P45131

query
sites
P45131

M
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M

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M1 (= M1) modified: Initiator methionine, Removed
L306 (= L314) mutation to R: Can no longer use acetyl-CoA as acyl donor, but can use succinyl-CoA.

Q6FEQ3 Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.46 from Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1) (see paper)
42% identity, 97% coverage: 9:366/368 of query aligns to 17:375/387 of Q6FEQ3

query
sites
Q6FEQ3

H

Q

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F

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R

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R323 (≠ L314) mutation to L: Can no longer use succinyl-CoA as acyl donor, but can use acetyl-CoA.

5w8oB Homoserine transacetylase metx from mycobacterium hassiacum (see paper)
36% identity, 95% coverage: 14:364/368 of query aligns to 9:343/346 of 5w8oB

query
sites
5w8oB

L

L

Y

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x
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binding calcium ion: D58 (= D69), V61 (≠ I72)

D2Z028 L-serine/homoserine O-acetyltransferase; Homoserine O-trans-acetylase; EC 2.3.1.30; EC 2.3.1.31 from Streptomyces lavendulae (see paper)
36% identity, 95% coverage: 16:363/368 of query aligns to 20:370/374 of D2Z028

query
sites
D2Z028

L

M

E

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F

W

D

L

N

Q

G

G

N

H

Y

Y

A

D

P

E

D

-

A

-

F

-

K

G

E

E

H

G

G

P

C

R

D

R

G

G

L

M

A

L

V

T

G

A

R

R

I

K

A

L

G

G

H

M

I

M

S

T

Y

Y

L

R

S

S

P

A

Q

Q

S

E

M

W

D

D

R

C

K

R

F

F

G

G

R

R

N

T

Y

R

V

I

-

G

-

E

-

R

-

R

-

R

A

A

T

D

D

Q

G

G

L

R

F

F

E

G

L

-

F

-

G

P

R

E

Y

F

E

E

V

V

E

E

R

S

Y

Y

M

L

E

D

Y

F

N

H

T

A

A

Q

N

R

F

F

S

A

R

D

I

R

F

F

D

D

P

P

L

N

S

S

Y

Y

L

L

Y

Y

I

L

V

S

K

H

A

A

I

M

N

D

T

Q

F

F

-

D

-

L

-

G

N

D

L

G

S

G

R

G

G

G

Y

G

D

G

S

G

L

A

H

P

D

G

A

A

V

L

S

S

R

R

I

M

R

R

A

V

Q

E

V

R

H

A

L

L

I

V

S

M

F

G

A

A

G

R

D

T

Y

D

L

I

F

L

F

F

P

P

-

L

E

S

E

Q

M

Q

E

Q

H

E

L

I

A

A

K

D

M

G

L

L

R

S

R

A

N

G

G

G

Q

A

A

D

H

V

S

S

Y

F

H

L

E

P

I

V

E

D

S

T

D

P

Y

A

G

G

H

H

D

D

A

A

F

F

L

L

V

V

E

D

V

I

D

E

K

R

F

F

D

G

F

P

I

P

I

V

R

A

E

K

I

F

L

L

G52 (≠ A48) mutation to A: Has much lower activity for the acetylation of L-serine but keeps the activity against L-homoserine. Utilizes L-homoserine as a substrate for acetylation but barely utilizes L-serine; when associated with G-55.
P55 (≠ G51) mutation to G: Can acetylate both L-serine and L-homoserine. Utilizes L-homoserine as a substrate for acetylation but barely utilizes L-serine; when associated with A-52.

7rytB Crystal structure of mycobacterium tuberculosis acetylated homoserine transacetylase with coenzyme a (see paper)
35% identity, 95% coverage: 14:363/368 of query aligns to 18:361/368 of 7rytB

query
sites
7rytB

L

L

Y

Q

L

L

E

E

S

S

G

G

R

A

I

V

L

I

E

D

P

D

Y

V

E

C

I

I

R

A

Y

V

E

Q

T

R

Y

W

G

G

E

K

L

L

N

S

E

P

A

A

K

R

D

D

N

N

V

V

I

V

L

V

V

V

C

L

H

H

A
|
A

L

L

S

T

G

G

S

D

H

S

H

H

A

I

A

T

G

G

-

P

L

A

Y

G

E

P

G

G

E

H

R

P

K

T

P

P

G

G

W

W

W

W

D

D

A

G

L

V

I

A

G

G

P

P

G

G

K

A

G

P

I

I

D

D

T

T

D

T

R

R

Y

W

F

C

V

A

V

V

C

A

T

T

N

N

V

V

I

L

G

G

S

G

C

C

F

R

G

G

S

S

T

T

G

G

P

P

M

S

S

S

P

L

Q

A

Y

R

P

D

S

G

E

-

E

K

P

P

Y

W

R

G

L

S

K

R

F

F

P

P

V

L

V

I

T

S

I

I

K

R

D

D

M

Q

I

V

R

Q

A

A

Q

D

R

V

Q

A

L

A

L

L

S

A

H

A

L

L

G

G

I

I

H

T

H

E

V

V

K

A

A

A

I

V

V

V

G

G

G

G

S
|
S

M

M

G

G

G

G

M

A

Q

R

A

A

L

L

Q

E

F

W

A

V

V

V

D

G

Y

Y

P

P

G

D

F

R

A

V

D

R

H

A

I

G

I

L

P

L

L

L

A

A

T

V

T

G

Y

A

A

R

T

A

R

T

P

A

W

D

V

Q

I

I

A

G

F

T

N

Q

K

T

V

T

A

Q

V

I

E

A

A

A

I

I

R

K

R

A

D

D

P

P

R

D

F

W

D

Q

N

S

G

G

N

D

Y

Y

-

H

-

E

-

T

-

G

-

R

A

A

P

P

D

D

A

A

F

-

K

-

E

-

H

-

G

-

C

-

D

-

G

G

L

L

A

R

V

L

G

A

R
|
R

I

R

A

F

G

A

H

H

I

L

S

T

Y
|
Y

L
x
R

S

G

P

E

Q

I

S

E

M

L

D

D

R

T

K
x
R

F

F

G

A

R

-

N

N

Y

H

V

N

A

Q

T

G

D

N

G

E

L

D

F

P

E

T

L

A

F

G

G

G

R

R

Y

Y

E

A

V

V

E

Q

R
x
S

Y
|
Y

M

L

E

E

Y
x
H

N

Q

T

G

A

D

N
x
K

F

L

S

L

R

S

I

R

F

F

D

D

P

A

L

G

S

S

Y

Y

L

V

Y

I

I

L

V

T

K

E

A

A

I

L

N

N

T

S

F

H

N

D

L

V

S

G

R

R

G

G

Y

R

D

G

S

G

L

V

H

S

D

A

A

A

V

L

S

R

R

A

I

C

R

P

A

V

Q

P

V

V

H

V

L

V

I

G

S

G

F

I

A

T

G

S

D

D

Y

R

L

L

F

Y

F

P

P

L

E

R

E

L

M

Q

E

Q

H

E

L

L

A

A

K

D

M

L

L

L

R

P

R

-

N

-

G

-

Q

G

A

C

H

A

S

G

Y

L

H

R

E

V

I

V

E

E

S

S

D

V

Y

Y

G

G

H

H

D
|
D

A

G

F

F

L

L

V

V

E

E

V

T

D

E

K

A

F

V

D

G

F

E

I

L

I

I

R

R

E

Q

I

T

L

L

binding coenzyme a: A52 (= A48), S150 (= S146), R220 (= R218), Y227 (= Y225), R228 (≠ L226), R236 (≠ K234), S257 (≠ R256), Y258 (= Y257), H261 (≠ Y260), K265 (≠ N264), D344 (= D346)

8f2lA Crystal structure of mycobacterium tuberculosis homoserine transacetylase in complex with l-homoserine (see paper)
35% identity, 95% coverage: 14:363/368 of query aligns to 18:361/367 of 8f2lA

query
sites
8f2lA

L

L

Y

Q

L

L

E

E

S

S

G

G

R

A

I

V

L

I

E

D

P

D

Y

V

E

C

I

I

R

A

Y

V

E

Q

T

R

Y

W

G

G

E

K

L

L

N

S

E

P

A

A

K

R

D

D

N

N

V

V

I

V

L

V

V

V

C

L

H

H

A
|
A

L
|
L

S
x
T

G

G

S

D

H

S

H

H

A

I

A

T

G

G

-

P

L

A

Y

G

E

P

G

G

E

H

R

P

K

T

P

P

G

G

W

W

W

W

D

D

A

G

L

V

I

A

G

G

P

P

G

G

K

A

G

P

I

I

D

D

T

T

D

T

R

R

Y

W

F

C

V

A

V

V

C

A

T

T

N

N

V

V

I

L

G

G

S

G

C

C

F

R

G

G

S

S

T

T

G

G

P

P

M

S

S

S

P

L

Q

A

Y

R

P

D

S

G

E

-

E

K

P

P

Y

W

R

G

L

S

K

R

F

F

P

P

V

L

V

I

T

S

I

I

K

R

D

D

M

Q

I

V

R

Q

A

A

Q

D

R

V

Q

A

L

A

L

L

S

A

H

A

L

L

G

G

I

I

H

T

H

E

V

V

K

A

A

A

I

V

V

V

G

G

G

G

S

S

M

M

G

G

G

G

M

A

Q

R

A

A

L

L

Q

E

F

W

A

V

V

V

D

G

Y

Y

P

P

G

D

F

R

A

V

D

R

H

A

I

G

I

L

P

L

L

L

A

A

T

V

T

G

Y

A

A

R

T

A

R

T

P

A

W

D

V

Q

I

I

A

G

F

T

N

Q

K

T

V

T

A

Q

V

I

E

A

A

A

I

I

R

K

R

A

D

D

P

P

R

D

F

W

D

Q

N

S

G

G

N

D

Y

Y

-

H

-

E

-

T

-

G

-

R

A

A

P

P

D

D

A

A

F

-

K

-

E

-

H

-

G

-

C

-

D

-

G

G

L

L

A

R

V

L

G

A

R
|
R

I

R

A

F

G

A

H

H

I

L

S

T

Y
|
Y

L

R

S

G

P

E

Q

I

S

E

M

L

D

D

R

T

K

R

F

F

G

A

R

-

N

N

Y

H

V

N

A

Q

T

G

D

N

G

E

L

D

F

P

E

T

L

A

F

G

G

G

R

R

Y

Y

E

A

V

V

E

Q

R

S

Y

Y

M

L

E

E

Y

H

N

Q

T

G

A

D

N

K

F

L

S

L

R

S

I

R

F

F

D

D

P

A

L

G

S

S

Y

Y

L

V

Y

I

I

L

V

T

K

E

A

A

I

L

N

N

T

S

F

H

N

D

L

V

S

G

R

R

G

G

Y

R

D

G

S

G

L

V

H

S

D

A

A

A

V

L

S

R

R

A

I

C

R

P

A

V

Q

P

V

V

H

V

L

V

I

G

S

G

F

I

A

T

G

S

D

D

Y

R

L

L

F

Y

F

P

P

L

E

R

E

L

M

Q

E

Q

H

E

L

L

A

A

K

D

M

L

L

L

R

P

R

-

N

-

G

-

Q

G

A

C

H

A

S

G

Y

L

H

R

E

V

I

V

E

E

S

S

D

V

Y

Y

G

G

H

H

D

D

A

G

F

F

L

L

V

V

E

E

V

T

D

E

K

A

F

V

D

G

F

E

I

L

I

I

R

R

E

Q

I

T

L

L

binding l-homoserine: A52 (= A48), L53 (= L49), T54 (≠ S50), R220 (= R218), Y227 (= Y225)

6puxA Homoserine transacetylase metx from mycobacterium tuberculosis (see paper)
35% identity, 95% coverage: 14:363/368 of query aligns to 19:362/366 of 6puxA

query
sites
6puxA

L

L

Y

Q

L

L

E

E

S

S

G

G

R

A

I

V

L

I

E

D

P

D

Y

V

E

C

I

I

R

A

Y

V

E

Q

T

R

Y

W

G

G

E

K

L

L

N

S

E

P

A

A

K

R

D

D

N

N

V

V

I

V

L

V

V

V

C

L

H

H

A

A

L

L

S

T

G

G

S

D

H

S

H

H

A

I

A

T

G

G

-

P

L

A

Y

G

E

P

G

G

E

H

R

P

K

T

P

P

G

G

W

W

W

W

D

D

A

G

L

V

I

A

G

G

P

P

G

G

K

A

G

P

I

I

D

D

T

T

D

T

R

R

Y

W

F

C

V

A

V

V

C

A

T

T

N

N

V

V

I

L

G

G

S

G

C

C

F

R

G

G

S

S

T

T

G

G

P

P

M

S

S

S

P

L

Q

A

Y

R

P

-

S

D

E

G

E

K

P

P

Y

W

R

G

L

S

K

R

F

F

P

P

V

L

V

I

T
x
S

I
|
I

K

R

D

D

M

Q

I

V

R

Q

A

A

Q

D

R

V

Q

A

L

A

L

L

S

A

H

A

L

L

G

G

I

I

H

T

H

E

V

V

K

A

A

A

I

V

V

V

G

G

G

G

S

S

M

M

G

G

G

G

M

A

Q

R

A

A

L

L

Q

E

F

W

A

V

V

V

D

G

Y

Y

P

P

G

D

F

R

A

V

D

R

H

A

I

G

I

L

P

L

L

L

A

A

T

V

T

G

Y

A

A

R

T

A

R

T

P

A

W

D

V

Q

I

I

A

G

F

T

N

Q

K

T

V

T

A

Q

V

I

E

A

A

A

I

I

R

K

R

A

D

D

P

P

R

D

F

W

D

Q

N

S

G

G

N

D

Y

Y

-

H

-

E

-

T

-

G

-

R

A

A

P

P

D

D

A

A

F

-

K

-

E

-

H

-

G

-

C

-

D

-

G

G

L

L

A

R

V

L

G

A

R

R

I

R

A

F

G

A

H

H

I

L

S

T

Y

Y

L

R

S

G

P

E

Q

I

S

E

M

L

D

D

R

T

K

R

F

F

G

A

R

-

N

N

Y

H

V

N

A

Q

T

G

D

N

G

E

L

D

F

P

E

T

L

A

F

G

G

G

R

R

Y

Y

E

A

V

V

E

Q

R

S

Y

Y

M

L

E

E

Y

H

N

Q

T

G

A

D

N

K

F

L

S

L

R

S

I

R

F

F

D

D

P

A

L

G

S

S

Y

Y

L

V

Y

I

I

L

V

T

K

E

A
|
A

I

L

N

N

T
x
S

F
x
H

N

D

L

V

S

G

R

R

G

G

Y

R

D

G

S

G

L

V

H

S

D

A

A

A

V

L

S

R

R

A

I

C

R

P

A

V

Q

P

V

V

H

V

L

V

I

G

S

G

F

I

A

T

G

S

D

D

Y

R

L

L

F

Y

F

P

P

L

E

R

E

L

M

Q

E

Q

H

E

L

L

A

A

K
x
D

M

L

L
|
L

R

P

R

-

N

-

G

-

Q

G

A

C

H

A

S

G

Y

L

H

R

E

V

I

V

E

E

S

S

D

V

Y

Y

G

G

H

H

D

D

A

G

F

F

L

L

V

V

E

E

V

T

D

E

K

A

F

V

D

G

F

E

I

L

I

I

R

R

E

Q

I

T

L

L

binding magnesium ion: S124 (≠ T119), I125 (= I120), A282 (= A280), S285 (≠ T283), H286 (≠ F284), D327 (≠ K325), L329 (= L327)

2vatA Crystal structure of deacetylcephalosporin c acetyltransferase in complex with coenzyme a (see paper)
33% identity, 95% coverage: 16:365/368 of query aligns to 20:347/347 of 2vatA

query
sites
2vatA

L

L

E

E

S

S

G

G

R

V

I

I

L

L

E

R

P

D

Y

V

E

P

I

V

R

A

Y

Y

E

K

T

S

Y

W

G

G

E

R

L

M

N

N

E

V

A

S

K

R

D

D

N

N

V

C

I

V

L

I

V

V

C

C

H

H

A

T

L

L

S

T

G

S

S

S

H

A

H

H

A

V

A

T

G

S

L

-

Y

-

E

-

G

-

E

-

R

-

K

-

P

-

G

-

W

W

W

W

D

P

A

T

L

L

I

F

G

G

P

Q

G

G

K

R

G

A

I

F

D

D

T

T

D

S

R

R

Y

Y

F

F

V

I

V

I

C

C

T

L

N

N

V

Y

I

L

G

G

S

S

C

P

F

F

G

G

S

S

T

A

G

G

P

P

M

C

S

S

P

P

Q

D

Y

P

P

D

S

A

E

E

E

R

P

P

Y

Y

R

G

L

A

K

K

F

F

P

P

V

R

V

T

T

T

I

I

K

R

D

D

M

D

I

V

R

R

A

I

Q

H

R

R

Q

Q

L

V

L

L

S

D

H

R

L

L

G

G

I

V

H

R

H

Q

V

I

K

A

A

A

I

V

V

V

G

G

G

A

S

S

M

M

G

G

G

G

M

M

Q

H

A

T

L

L

Q

E

F

W

A

A

V

F

D

F

Y

G

P

P

G

E

F

Y

A

V

D

R

H

K

I

I

I

V

P

P

L

I

A

A

T

T

T

S

Y

C

A

R

T

Q

R

S

P

G

W

W

V

C

I

A

A

A

F

W

N

F

K

E

V

T

A

Q

V

R

E

Q

A

C

I

I

R

Y

R

D

D

D

P

P

R

K

F

Y

D

L

N

D

G

G

N

E

Y

Y

A

D

P

V

D

D

A

-

F

-

K

-

E

D

H

Q

G

P

C

V

D

R

G

G

L

L

A

E

V

T

G

A

R
|
R

I

K

A

I

G

A

H

N

I

L

S

T

Y
|
Y

L
x
K

S

S

P

K

Q

P

S

A

M

M

D

D

R

E

K
x
R

F

F

G

H

R

-

N

-

Y

-

V

-

A

M

T

A

D

P

G

G

L

V

F

Q

E

P

L

I

F

-

G

-

R

-

Y

E

E

A

V

V

E

S

R
x
S

Y
|
Y

M

L

E

R

Y
|
Y

N
x
Q

T

A

A

Q

N
x
K

F

F

S

A

R

A

I

S

F

F

D

D

P

A

L

N

S

C

Y

Y

L

I

Y

A

I

M

V

T

K

L

A

K

I

F

N

D

T

T

F

H

N

D

L

I

S

S

R

R

G

G

Y

R

-

A

D

G

S

S

L

I

H

P

D

E

A

A

V

L

S

A

R

M

I

I

R

T

A

Q

Q

P

V

A

H

L

L

I

I

I

S

C

F

A

A

R

G

S

D

D

Y

G

L

L

F

Y

-

S

F

F

P

D

E

E

E

H

M

V

E

E

H

-

L

-

A

-

K

-

M

-

L

M

R

G

R

R

N

S

G

I

Q

P

A

N

H

S

S

R

Y

L

H

C

E

V

I

V

E

D

S

T

D

N

Y

E

G

G

H
|
H

D
|
D

A

F

F

F

L

V

V
x
M

E

E

V

A

D

D

K

K

F

V

D

N

F

D

I

A

I

V

R

R

E

G

I

F

L

L

E

D

E

Q

binding coenzyme a: R210 (= R218), Y217 (= Y225), K218 (≠ L226), R226 (≠ K234), S241 (≠ R256), Y242 (= Y257), Y245 (= Y260), Q246 (≠ N261), K249 (≠ N264), H327 (= H345), D328 (= D346), M332 (≠ V350)

2vavB Crystal structure of deacetylcephalosporin c acetyltransferase (dac- soak) (see paper)
32% identity, 95% coverage: 16:366/368 of query aligns to 21:350/350 of 2vavB

query
sites
2vavB

L

L

E

E

S

S

G

G

R

V

I

I

L

L

E

R

P

D

Y

V

E

P

I

V

R

A

Y

Y

E

K

T

S

Y

W

G

G

E

R

L

M

N

N

E

V

A

S

K

R

D

D

N

N

V

C

I

V

L

I

V

V

C

C

H

H

A
x
T

L
|
L

S
x
T

G

S

S

S

H

A

H

H

A

V

A

T

G

S

L

-

Y

-

E

-

G

-

E

-

R

-

K

-

P

-

G

-

W

W

W

W

D

P

A

T

L

L

I

F

G

G

P

Q

G

G

K

R

G

A

I

F

D

D

T

T

D

S

R

R

Y

Y

F

F

V

I

V

I

C

C

T

L

N

N

V

Y

I

L

G

G

S

S

C

P

F

F

G

G

S

S

T

A

G

G

P

P

M

C

S

S

P

P

Q

D

Y

P

P

D

S

A

E

Q

E

R

P

P

Y

Y

R

G

L

A

K

K

F

F

P

P

V

R

V

T

T

T

I

I

K

R

D

D

M

D

I

V

R

R

A

I

Q

H

R

R

Q

Q

L

V

L

L

S

D

H

R

L

L

G

G

I

V

H

R

H

Q

V

I

K

A

A

A

I

V

V

V

G

G

G

A

S
|
S

M

M

G

G

G

G

M

M

Q

H

A

T

L

L

Q

E

F

W

A

A

V

F

D

F

Y

G

P

P

G

E

F

Y

A

V

D

R

H

K

I

I

I

V

P

P

L

I

A

A

T

T

T

S

Y

C

A

R

T

Q

R

S

P

G

W

W

V

C

I

A

A

A

F

W

N

F

K

E

V

T

A

Q

V

R

E

Q

A

C

I

I

R

Y

R

D

D

D

P

P

R

K

F

Y

D

L

N

D

G

G

N

E

Y

Y

A

D

P

V

D

D

A

-

F

-

K

-

E

D

H

Q

G

P

C

V

D

R

G

G

L

L

A

E

V

T

G

A

R
|
R

I

K

A

I

G

A

H

N

I

L

S

T

Y
|
Y

L
x
K

S

S

P

K

Q

P

S

A

M

M

D

D

R

E

K
x
R

F

F

G

H

R

-

N

-

Y

-

V

-

A

M

T

A

D

P

G

G

L

V

F

G

E

Q

L

P

F

I

G

-

R

-

Y

E

E

A

V

V

E

S

R

S

Y

Y

M

L

E

R

Y

Y

N

Q

T

A

A

Q

N

K

F

F

S

A

R

A

I

S

F

F

D

D

P

A

L

N

S

C

Y

Y

L

I

Y

A

I

M

V

T

K

L

A

K

I

F

N

D

T

T

F

H

N

D

L

I

S

S

R

R

G

G

-

R

Y

A

D

G

S

S

L

I

H

P

D

E

A

A

V

L

S

A

R

M

I

I

R

T

A

Q

Q

P

V

A

H

L

L

I

I

I

S

C

F

A

A

R

G

S

D

D

Y

G

L

L

F

Y

-

S

F

F

P

D

E

E

E

H

M

V

E

E

H

-

L

-

A

-

K

-

M

-

L

M

R

G

R

R

N

S

G

I

Q

P

A

N

H

S

S

R

Y

L

H

C

E

V

I

V

E

D

S

T

D

N

Y

E

G

G

H

H

D
|
D

A

F

F

F

L

V

V

M

E

E

V

A

D

D

K

K

F

V

D

N

F

D

I

A

I

V

R

R

E

G

I

F

L

L

E

D

E

Q

E

S

binding 4-(3-acetoxymethyl-2-carboxy-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-en-7-ylcarbamoyl)-1-carboxy-butyl-ammonium: T53 (≠ A48), L54 (= L49), T55 (≠ S50), S142 (= S146), R211 (= R218), Y218 (= Y225), K219 (≠ L226), R227 (≠ K234), D330 (= D346)

6ioiA Crystal structure of homoserine o-acetyltransferase in complex with coa from mycobacterium smegmatis atcc 19420 (see paper)
34% identity, 95% coverage: 14:364/368 of query aligns to 19:363/366 of 6ioiA

query
sites
6ioiA

L

L

Y

T

L

L

E

E

S

N

G

G

R

T

I

V

L

L

E

P

P

D

Y

V

E

T

I

I

R

A

Y

V

E

Q

T

R

Y

W

G

G

E

E

L

L

N

A

E

P

A

D

K

R

D

G

N

N

V

V

I

V

L

M

V

V

C

L

H

H

A

A

L

L

S
x
T

G

G

S

D

H

S

H

H

A

V

A

T

G

G

-

P

L

A

Y

G

E

D

G

G

E

H

R

P

K

T

P

A

G

G

W

W

W

W

D

D

A

G

L

V

I

A

G

G

P

P

G

G

K

A

G

P

I

I

D

D

T

T

D

D

R

H

Y

W

F

C

V

A

V

I

C

A

T

T

N

N

V

V

I

L

G

G

S

G

C

C

F

R

G

G

S

S

T

T

G

G

P

P

M

G

S

S

P

-

Q

L

Y

A

P

P

S

D

E

G

E

K

P

P

Y

W

R

G

L

S

K

R

F

F

P

P

V

Q

V

I

T

T

I

I

K

R

D

D

M

Q

I

V

R

A

A

A

Q

D

R

R

Q

A

L

A

L

L

S

A

H

A

L

L

G

G

I

I

H

T

H

E

V

V

K

A

A

A

I

V

V

V

G

G

G

G

S

S

M

M

G

G

G

G

M

A

Q

R

A

A

L

L

Q

E

F

W

A

L

V

V

D

T

Y

H

P

P

G

D

F

D

A

V

D

R

H

A

I

G

I

L

P

V

L

L

A

A

T

V

T

G

Y

A

A

R

T

A

R

T

P

A

W

D

V

Q

I

I

A

G

F

T

N

Q

K

S

V

T

A

Q

V

V

E

A

A

A

I

I

R

K

R

A

D

D

P

P

R

D

F

W

D

Q

N

G

G

G

N

D

Y

Y

A

-

P

-

D

H

A

G

F

T

K

G

E

R

H

A

G

P

C

T

D

E

G

G

L

M

A

E

V

I

G

A

R
|
R

I

R

A

F

G

A

H

H

I

L

S

T

Y
|
Y

L

R

S

G

P

E

Q

E

S

E

M

L

D

D

R

D

K

R

F

F

G

A

R

-

N

N

Y

T

V

P

A
x
Q

T

D

D

D

G

E

L

D

F

P

E

L

L

T

F

G

G

G

R

R

Y

Y

E

A

V

V

E

Q

R
x
S

Y
|
Y

M

L

E

E

Y
|
Y

N

Q

T

G

A

G

N
x
K

F

L

S

A

R

R

I

R

F

F

D

D

P

P

L

G

S

T

Y

Y

L

V

Y

V

I

L

V

S

K

D

A

A

I

L

N

S

T

S

F

H

N

D

L

V

S

G

R

R

G

G

Y

R

D

G

S

G

L

V

H

E

D

A

A

A

V

L

S

R

R

S

I

C

R

P

A

V

Q

P

V

V

H

V

L

V

I

G

S

G

F

I

A

T

G

S

D

D

Y

R

L

L

F

Y

F

P

P

I

E

R

E

L

M

Q

E

Q

H

E

L

L

A

A

K

E

M

L

L

L

R

P

R

-

N

-

G

-

Q

G

A

C

H

Q

S

G

Y

L

H

D

E

V

I

V

E

D

S

S

D

I

Y

Y

G

G

H

H

D
|
D

A

G

F

F

L
|
L

V

V

E

E

V

T

D

E

K

L

F

V

D

G

F

K

I

L

I

I

R

R

E

R

I

T

L

L

E

E

binding coenzyme a: T55 (≠ S50), R221 (= R218), Y228 (= Y225), Q243 (≠ A241), S258 (≠ R256), Y259 (= Y257), Y262 (= Y260), K266 (≠ N264), D345 (= D346), L348 (= L349)

6iohA Crystal structure of homoserine o-acetyltransferase in complex with homoserine from mycobacterium smegmatis atcc 19420 (see paper)
34% identity, 95% coverage: 14:364/368 of query aligns to 19:363/375 of 6iohA

query
sites
6iohA

L

L

Y

T

L

L

E

E

S

N

G

G

R

T

I

V

L

L

E

P

P

D

Y

V

E

T

I

I

R

A

Y

V

E

Q

T

R

Y

W

G

G

E

E

L

L

N

A

E

P

A

D

K

R

D

G

N

N

V

V

I

V

L

M

V

V

C

L

H

H

A

A

L

L

S
x
T

G

G

S

D

H

S

H

H

A

V

A

T

G

G

-

P

L

A

Y

G

E

D

G

G

E

H

R

P

K

T

P

A

G

G

W

W

W

W

D

D

A

G

L

V

I

A

G

G

P

P

G

G

K

A

G

P

I

I

D

D

T

T

D

D

R

H

Y

W

F

C

V

A

V

I

C

A

T

T

N

N

V

V

I

L

G

G

S

G

C

C

F

R

G

G

S

S

T

T

G

G

P

P

M

G

S

S

P

-

Q

L

Y

A

P

P

S

D

E

G

E

K

P

P

Y

W

R

G

L

S

K

R

F

F

P

P

V

Q

V

I

T

T

I

I

K

R

D

D

M

Q

I

V

R

A

A

A

Q

D

R

R

Q

A

L

A

L

L

S

A

H

A

L

L

G

G

I

I

H

T

H

E

V

V

K

A

A

A

I

V

V

V

G

G

G

G

S
|
S

M

M

G

G

G

G

M

A

Q

R

A

A

L

L

Q

E

F

W

A

L

V

V

D

T

Y

H

P

P

G

D

F

D

A

V

D

R

H

A

I

G

I

L

P

V

L

L

A

A

T

V

T

G

Y

A

A

R

T

A

R

T

P

A

W

D

V

Q

I

I

A

G

F

T

N

Q

K

S

V

T

A

Q

V

V

E

A

A

A

I

I

R

K

R

A

D

D

P

P

R

D

F

W

D

Q

N

G

G

G

N

D

Y

Y

A

-

P

-

D

H

A

G

F

T

K

G

E

R

H

A

G

P

C

T

D

E

G

G

L

M

A

E

V

I

G

A

R
|
R

I

R

A

F

G

A

H

H

I

L

S

T

Y
|
Y

L

R

S

G

P

E

Q

E

S

E

M

L

D

D

R

D

K

R

F

F

G

A

R

-

N

N

Y

T

V

P

A

Q

T

D

D

D

G

E

L

D

F

P

E

L

L

T

F

G

G

G

R

R

Y

Y

E

A

V

V

E

Q

R

S

Y

Y

M

L

E

E

Y

Y

N

Q

T

G

A

G

N

K

F

L

S

A

R

R

I

R

F

F

D

D

P

P

L

G

S

T

Y

Y

L

V

Y

V

I

L

V

S

K

D

A

A

I

L

N

S

T

S

F

H

N

D

L

V

S

G

R

R

G

G

Y

R

D

G

S

G

L

V

H

E

D

A

A

A

V

L

S

R

R

S

I

C

R

P

A

V

Q

P

V

V

H

V

L

V

I

G

S

G

F

I

A

T

G

S

D

D

Y

R

L

L

F

Y

F

P

P

I

E

R

E

L

M

Q

E

Q

H

E

L

L

A

A

K

E

M

L

L

L

R

P

R

-

N

-

G

-

Q

G

A

C

H

Q

S

G

Y

L

H

D

E

V

I

V

E

D

S

S

D

I

Y

Y

G

G

H
|
H

D
|
D

A

G

F

F

L

L

V

V

E

E

V

T

D

E

K

L

F

V

D

G

F

K

I

L

I

I

R

R

E

R

I

T

L

L

E

E

binding l-homoserine: T55 (≠ S50), S151 (= S146), R221 (= R218), Y228 (= Y225), H344 (= H345), D345 (= D346)

Q10341 Serine O-succinyltransferase; SST; EC 2.3.1.- from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
37% identity, 75% coverage: 13:287/368 of query aligns to 89:359/504 of Q10341

query
sites
Q10341

P

P

L

F

Y

L

L

C

E

D

S

H

G

G

R

G

I

I

L

L

E

P

P

K

Y

F

E

E

I

I

R

A

Y

Y

E

E

T

T

Y

W

G

G

E

T

L

L

N

N

E

K

A

D

K

H

D

S

N

N

V

A

I

I

L

L

V

L

C

H

H

T

A

G

L

L

S

S

G

A

S

S

H

S

H

H

A

A

A

H

G

S

L

H

Y

P

E

E

G

N

E

T

R

-

K

A

P

P

G

G

W

W

W

W

D

E

A

Q

L

F

I

I

G

G

P

P

G

G

K

K

G

D

I

V

D

D

T

T

D

N

R

K

Y

F

F

F

V

V

V

I

C

C

T

T

N

N

V

V

I

L

G

G

S

S

C

C

F

Y

G

G

S

S

T

T

G

G

P

P

M

S

S

S

P

V

Q

D

Y

P

P

G

S

D

E

G

E

K

P

H

Y

Y

R

A

L

T

K

R

F

F

P

P

V

I

V

I

T

T

I

V

K

N

D

D

M

M

I

I

R

R

A

A

Q

Q

R

L

Q

L

L

L

L

L

S

D

H

H

L

L

G

K

I

I

H

E

H

K

V

L

K

Y

A

A

I

S

V

V

G

G

G

S

S

S

M

L

G

G

G

G

M

M

Q

Q

A

S

L

L

Q

T

F

L

A

G

V

A

D

L

Y

A

P

P

G

H

F

R

A

V

D

G

H

R

I

I

I

A

P

S

L

I

A

S

T

G

T

G

Y

A

A

R

T

S

R

H

P

P

W

Y

V

S

I

I

A

A

F

L

N

R

K

F

V

T

A

Q

V

R

E

Q

A

I

I

L

R

M

R

N

D

D

P

P

R

Y

F

W

D

N

N

R

G

G

N

F

Y

Y

A

Y

P

-

D

D

A

G

F

V

K

P

E

P

H

H

G

-

C

-

D

T

G

G

L

M

A

K

V

L

G

A

R

R

I

E

A

V

G

A

H

T

I

I

S

S

Y

Y

L

R

S

S

P

G

Q

P

S

E

M

W

D

E

R

Q

K

R

F

F

G

G

R

N

N

R

Y

R

V

A

A

D

T

P

D

S

G

V

L

S

F

P

E

A

L

F

F

C

G

P

R

D

Y

F

E

L

V

I

E

E

R

T

Y

Y

M

L

E

D

Y

H

N

A

T

G

A

E

N

K

F

F

S

C

R

L

I

Q

F

Y

D

D

P

P

L

N

S

S

Y

L

L

L

Y

Y

I

I

V

S

K

K

A

A

I

M

N

D

T

M

F

H

N

D

L

M

S

S

Sites not aligning to the query:

426 G→D: In cys2-1: Leads to auxotrophy for cysteine.

Query Sequence

>WP_013553394.1 NCBI__GCF_000186245.1:WP_013553394.1
MKIETHTTHFTSPLYLESGRILEPYEIRYETYGELNEAKDNVILVCHALSGSHHAAGLYE
GERKPGWWDALIGPGKGIDTDRYFVVCTNVIGSCFGSTGPMSPQYPSEEPYRLKFPVVTI
KDMIRAQRQLLSHLGIHHVKAIVGGSMGGMQALQFAVDYPGFADHIIPLATTYATRPWVI
AFNKVAVEAIRRDPRFDNGNYAPDAFKEHGCDGLAVGRIAGHISYLSPQSMDRKFGRNYV
ATDGLFELFGRYEVERYMEYNTANFSRIFDPLSYLYIVKAINTFNLSRGYDSLHDAVSRI
RAQVHLISFAGDYLFFPEEMEHLAKMLRRNGQAHSYHEIESDYGHDAFLVEVDKFDFIIR
EILEEECG

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory