SitesBLAST
Comparing WP_013643655.1 NCBI__GCF_000191585.1:WP_013643655.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
1omoA Alanine dehydrogenase dimer w/bound NAD (archaeal) (see paper)
51% identity, 98% coverage: 8:334/335 of query aligns to 2:320/320 of 1omoA
- active site: R52 (= R60), D219 (= D233)
- binding nicotinamide-adenine-dinucleotide: T109 (= T120), G134 (= G145), T135 (≠ K146), Q136 (= Q147), Y156 (≠ F167), D157 (≠ C168), V158 (≠ R169), R159 (≠ T170), T195 (= T209), P196 (= P210), G217 (= G231), D219 (= D233), K223 (= K237), S290 (= S304), T291 (= T305), G292 (= G306)
O28608 Alanine dehydrogenase; AlaDH; EC 1.4.1.1 from Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16) (see paper)
51% identity, 98% coverage: 8:334/335 of query aligns to 2:320/322 of O28608
6t3eB Structure of thermococcus litoralis delta(1)-pyrroline-2-carboxylate reductase in complex with nadh and l-proline (see paper)
41% identity, 97% coverage: 10:333/335 of query aligns to 2:325/325 of 6t3eB
- binding 1,4-dihydronicotinamide adenine dinucleotide: S82 (≠ T91), T111 (= T120), G136 (= G145), V137 (≠ K146), Q138 (= Q147), D159 (≠ C168), I160 (≠ R169), A199 (≠ V208), T200 (= T209), T201 (≠ P210), A202 (= A211), V206 (= V215), V221 (≠ M230), G222 (= G231), W223 (≠ A232), S296 (= S304), V297 (≠ T305), G298 (= G306)
- binding proline: R39 (≠ K47), M54 (= M62), K67 (= K75), R110 (= R119)
4mp6A Staphyloferrin b precursor biosynthetic enzyme sbnb bound to citrate and NAD+ (see paper)
29% identity, 97% coverage: 8:333/335 of query aligns to 2:333/334 of 4mp6A
- active site: I60 (vs. gap), M236 (≠ D233)
- binding nicotinamide-adenine-dinucleotide: R92 (≠ T91), R120 (= R119), T121 (= T120), G146 (= G145), L147 (≠ K146), I148 (≠ Q147), D170 (≠ C168), Q171 (≠ R169), C211 (≠ V208), T212 (= T209), V213 (≠ P210), I233 (≠ M230), G306 (= G306)
Q14894 Ketimine reductase mu-crystallin; NADP-regulated thyroid-hormone-binding protein; EC 1.5.1.25 from Homo sapiens (Human) (see paper)
30% identity, 93% coverage: 11:320/335 of query aligns to 7:308/314 of Q14894
2i99A Crystal structure of human mu_crystallin at 2.6 angstrom (see paper)
30% identity, 93% coverage: 11:320/335 of query aligns to 6:307/312 of 2i99A
- active site: G59 (≠ R60), S228 (≠ D233)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: D81 (≠ E82), S90 (≠ T91), H91 (≠ V92), R118 (= R119), T119 (= T120), G142 (= G143), A143 (= A144), G144 (= G145), V145 (≠ K146), Q146 (= Q147), N167 (≠ C168), R168 (= R169), T169 (= T170), V203 (= V208), T204 (= T209), L205 (≠ P210), A206 (= A211), V225 (≠ M230), G226 (= G231), S291 (= S304), L292 (≠ T305), G293 (= G306)
4mpdA Staphyloferrin b precursor biosynthetic enzyme sbnb bound a- ketoglutarate and NAD+ (see paper)
28% identity, 97% coverage: 8:333/335 of query aligns to 2:317/318 of 4mpdA
- active site: I53 (≠ R60), M224 (≠ D233)
- binding 2-oxoglutaric acid: K43 (= K47), R51 (≠ D58), M55 (= M62), K64 (= K75), I66 (≠ V77), R80 (≠ T91), M289 (≠ T305)
- binding nicotinamide-adenine-dinucleotide (acidic form): R80 (≠ T91), R108 (= R119), T109 (= T120), G134 (= G145), I136 (≠ Q147), D158 (≠ C168), Q159 (≠ R169), F160 (≠ T170), T200 (= T209), V201 (≠ P210), I221 (≠ M230)
4bv9A Crystal structure of the NADPH form of mouse mu-crystallin. (see paper)
33% identity, 84% coverage: 41:320/335 of query aligns to 39:299/303 of 4bv9A
- active site: G58 (≠ R60), S220 (≠ D233)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: S82 (≠ T91), H83 (≠ V92), T111 (= T120), G134 (= G143), G136 (= G145), V137 (≠ K146), Q138 (= Q147), N159 (≠ C168), R160 (= R169), T161 (= T170), V195 (= V208), T196 (= T209), M197 (≠ P210), A198 (= A211), V217 (≠ M230), G218 (= G231), S283 (= S304), L284 (≠ T305), G285 (= G306)
- binding pyruvic acid: R45 (≠ K47), M60 (= M62), K73 (= K75), R110 (= R119)
5gziA Cyclodeaminase_pa
34% identity, 77% coverage: 70:328/335 of query aligns to 76:329/354 of 5gziA
- binding nicotinamide-adenine-dinucleotide: Y85 (≠ V79), T97 (= T91), R125 (= R119), T126 (= T120), G151 (= G145), A152 (≠ K146), Q153 (= Q147), D174 (≠ C168), T175 (≠ R169), H179 (≠ S173), A212 (≠ V208), T213 (= T209), S214 (≠ P210), V215 (vs. gap), V237 (≠ M230), G238 (= G231), A239 (= A232), S305 (= S304), T306 (= T305), G307 (= G306)
- binding (2S)-piperidine-2-carboxylic acid: K81 (= K75), R125 (= R119), A239 (= A232), T306 (= T305), G307 (= G306)
Sites not aligning to the query:
5yu4A Structural basis for recognition of l-lysine, l-ornithine, and l-2,4- diamino butyric acid by lysine cyclodeaminase (see paper)
34% identity, 77% coverage: 70:328/335 of query aligns to 72:325/344 of 5yu4A
- binding 2,4-diaminobutyric acid: K77 (= K75), R121 (= R119), T302 (= T305), G303 (= G306)
- binding nicotinamide-adenine-dinucleotide: Y81 (≠ V79), T93 (= T91), I94 (≠ V92), R121 (= R119), T122 (= T120), G147 (= G145), A148 (≠ K146), Q149 (= Q147), D170 (≠ C168), T171 (≠ R169), H175 (≠ S173), A208 (≠ V208), T209 (= T209), S210 (≠ P210), V211 (vs. gap), V218 (= V215), V233 (≠ M230), A235 (= A232), S301 (= S304), T302 (= T305), G303 (= G306)
Sites not aligning to the query:
5yu3A Structural basis for recognition of l-lysine, l-ornithine, and l-2,4- diamino butyric acid by lysine cyclodeaminase (see paper)
34% identity, 77% coverage: 70:328/335 of query aligns to 72:325/344 of 5yu3A
- binding nicotinamide-adenine-dinucleotide: Y81 (≠ V79), T93 (= T91), I94 (≠ V92), T122 (= T120), G147 (= G145), A148 (≠ K146), Q149 (= Q147), D170 (≠ C168), T171 (≠ R169), A208 (≠ V208), T209 (= T209), S210 (≠ P210), V211 (vs. gap), V233 (≠ M230), A235 (= A232), S301 (= S304), T302 (= T305), G303 (= G306)
- binding proline: K77 (= K75), R121 (= R119)
Sites not aligning to the query:
5gzlA Cyclodeaminase_pa
34% identity, 77% coverage: 70:328/335 of query aligns to 76:329/357 of 5gzlA
- binding lysine: D240 (= D233), R267 (≠ H260), E268 (≠ S261)
- binding nicotinamide-adenine-dinucleotide: Y85 (≠ V79), T97 (= T91), I98 (≠ V92), T126 (= T120), G151 (= G145), A152 (≠ K146), Q153 (= Q147), D174 (≠ C168), T175 (≠ R169), H179 (≠ S173), A212 (≠ V208), T213 (= T209), S214 (≠ P210), V222 (= V215), V237 (≠ M230), G238 (= G231), A239 (= A232), D240 (= D233), K244 (= K237), S305 (= S304), T306 (= T305), G307 (= G306)
Sites not aligning to the query:
4bvaA Crystal structure of the NADPH-t3 form of mouse mu-crystallin. (see paper)
32% identity, 84% coverage: 41:320/335 of query aligns to 40:298/303 of 4bvaA
- active site: G59 (≠ R60), S219 (≠ D233)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: T106 (= T116), R109 (= R119), T110 (= T120), G135 (= G145), V136 (≠ K146), Q137 (= Q147), N158 (≠ C168), R159 (= R169), T160 (= T170), N163 (≠ S173), V194 (= V208), T195 (= T209), M196 (≠ P210), A197 (= A211), V216 (≠ M230), S282 (= S304), L283 (≠ T305), G284 (= G306)
- binding 3,5,3'triiodothyronine: R46 (≠ K47), F57 (≠ D58), G59 (≠ R60), V76 (= V77), F78 (≠ V79), S219 (≠ D233), R220 (≠ A234), W223 (≠ K237), E247 (≠ H260)
Q88H32 Ornithine cyclodeaminase; OCD; EC 4.3.1.12 from Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440) (see paper)
32% identity, 83% coverage: 57:334/335 of query aligns to 53:323/350 of Q88H32
- K69 (= K75) binding L-ornithine
- T84 (= T91) binding NAD(+)
- R112 (= R119) binding L-ornithine; binding NAD(+)
- AQ 139:140 (≠ KQ 146:147) binding NAD(+)
- D161 (≠ C168) binding NAD(+)
- T202 (= T209) binding NAD(+)
- VGGD 225:228 (≠ MGAD 230:233) binding NAD(+)
- D228 (= D233) binding L-ornithine
- K232 (= K237) binding NAD(+)
- S293 (= S304) binding NAD(+)
- V294 (≠ T305) binding L-ornithine
Sites not aligning to the query:
- 45 binding L-ornithine
- 331 binding NAD(+)
1u7hA Structure and a proposed mechanism for ornithine cyclodeaminase from pseudomonas putida (see paper)
32% identity, 83% coverage: 57:334/335 of query aligns to 52:322/341 of 1u7hA
- active site: E55 (≠ R60), D227 (= D233)
- binding nicotinamide-adenine-dinucleotide: T83 (= T91), R111 (= R119), T112 (= T120), G137 (= G145), A138 (≠ K146), Q139 (= Q147), D160 (≠ C168), T161 (≠ R169), V200 (= V208), T201 (= T209), A202 (≠ P210), I209 (≠ V215), V224 (≠ M230), G225 (= G231), D227 (= D233), K231 (= K237), S292 (= S304), V293 (≠ T305), G294 (= G306)
1x7dA Crystal structure analysis of ornithine cyclodeaminase complexed with NAD and ornithine to 1.6 angstroms (see paper)
32% identity, 83% coverage: 57:334/335 of query aligns to 52:322/340 of 1x7dA
- active site: E55 (≠ R60), D227 (= D233)
- binding nicotinamide-adenine-dinucleotide: T83 (= T91), R111 (= R119), T112 (= T120), G137 (= G145), A138 (≠ K146), Q139 (= Q147), D160 (≠ C168), T161 (≠ R169), V200 (= V208), T201 (= T209), A202 (≠ P210), I209 (≠ V215), V224 (≠ M230), G225 (= G231), D227 (= D233), K231 (= K237), S292 (= S304), V293 (≠ T305), G294 (= G306)
- binding L-ornithine: V53 (≠ D58), E55 (≠ R60), M57 (= M62), K68 (= K75), V70 (= V77), N71 (= N78), G72 (≠ V79), R111 (= R119), D227 (= D233), V293 (≠ T305)
Sites not aligning to the query:
4m54A The structure of the staphyloferrin b precursor biosynthetic enzyme sbnb bound to n-(1-amino-1-carboxyl-2-ethyl)-glutamic acid and nadh (see paper)
27% identity, 97% coverage: 8:333/335 of query aligns to 2:309/310 of 4m54A
- active site: I55 (= I61), M231 (≠ D233)
- binding N-[(2S)-2-amino-2-carboxyethyl]-L-glutamic acid: Y45 (= Y49), R53 (≠ L59), M57 (= M62), K71 (= K75), I73 (≠ V77), R87 (≠ T91), R115 (= R119)
- binding 1,4-dihydronicotinamide adenine dinucleotide: R87 (≠ T91), T116 (= T120), G141 (= G145), L142 (≠ K146), I143 (≠ Q147), D165 (≠ C168), Q166 (≠ R169), T207 (= T209), T209 (≠ A211), I228 (≠ M230)
6rqaB Crystal structure of the iminosuccinate reductase of paracoccus denitrificans in complex with NAD+ (see paper)
31% identity, 95% coverage: 10:327/335 of query aligns to 4:316/322 of 6rqaB
- binding Tb-Xo4: E49 (≠ L59), D50 (≠ R60), N76 (≠ E82)
- binding nicotinamide-adenine-dinucleotide: T113 (= T120), G138 (= G145), Q140 (= Q147), P162 (≠ R169), H163 (≠ T170), I199 (≠ V208), T200 (= T209), S201 (≠ P210), S202 (≠ A211), M221 (= M230), G222 (= G231), D224 (= D233), K228 (= K237), G293 (≠ S304), T294 (= T305), G295 (= G306)
6rqaA Crystal structure of the iminosuccinate reductase of paracoccus denitrificans in complex with NAD+ (see paper)
31% identity, 95% coverage: 10:327/335 of query aligns to 4:316/322 of 6rqaA
- binding nicotinamide-adenine-dinucleotide: H85 (≠ V92), T113 (= T120), G138 (= G145), H139 (≠ K146), Q140 (= Q147), N161 (≠ C168), P162 (≠ R169), H163 (≠ T170), M166 (≠ S173), I199 (≠ V208), T200 (= T209), S201 (≠ P210), S202 (≠ A211), M221 (= M230), G222 (= G231), D224 (= D233), K228 (= K237), G293 (≠ S304)
A1B8Z0 Iminosuccinate reductase; EC 1.4.1.- from Paracoccus denitrificans (strain Pd 1222) (see paper)
31% identity, 95% coverage: 10:327/335 of query aligns to 2:314/320 of A1B8Z0
- R110 (= R119) binding NAD(+)
- HQ 137:138 (≠ KQ 146:147) binding NAD(+)
- N159 (≠ C168) binding NAD(+)
- S199 (≠ P210) binding NAD(+)
- MGTD 219:222 (≠ MGAD 230:233) binding NAD(+)
- K226 (= K237) binding NAD(+)
- G291 (≠ S304) binding NAD(+)
Query Sequence
>WP_013643655.1 NCBI__GCF_000191585.1:WP_013643655.1
MKDATRYETLLLKQSEIKELIEMKEIIESVETAYTVHATRNVQMPAKKYLFFKKYNGDLR
IMPAFIKNMDEAGVKCVNVHPENPVKYNLPTVMGIIQLFDPKSGFPLSVMDGTWITNMRT
GAAAGVGTKYLAREDSKTLGIIGAGKQAFTQLMALKEVMDIEHAHVFCRTCSSRENFADM
ARKRFDIDINAVSTAEEAVKNMDVVVTVTPANKPVIKTEWITEGTHINAMGADAPGKQEL
EVGILQKARIFIDCWEQARHSGEINVPVHDGIITRKSISSKIGDVIIGNAEGRISDEDIT
VFDSTGLAVQDMVTGWKVYEEAVKKGVGTVINFLD
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory