SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing WP_013644861.1 NCBI__GCF_000191585.1:WP_013644861.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

7d7oB Crystal structure of cystathionine gamma-lyase from bacillus cereus atcc 14579 (see paper)
50% identity, 99% coverage: 1:374/377 of query aligns to 1:376/377 of 7d7oB

query
sites
7d7oB

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binding pyridoxal-5'-phosphate: Y44 (= Y44), R46 (= R46), G74 (= G74), M75 (= M75), Y98 (= Y98), D170 (= D170), T172 (= T172), S192 (= S192), T194 (= T194), K195 (= K195)

7ba4A Structure of cystathionine gamma-lyase from pseudomonas aeruginosa
50% identity, 99% coverage: 3:374/377 of query aligns to 7:371/377 of 7ba4A

query
sites
7ba4A

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binding pyridoxal-5'-phosphate: G66 (= G74), L67 (≠ M75), Y90 (= Y98), D163 (= D170), F166 (= F173), S185 (= S192), T187 (= T194), K188 (= K195)

4iyoB Crystal structure of cystathionine gamma lyase from xanthomonas oryzae pv. Oryzae (xometc) in complex with e-site serine, a-site serine, a- site external aldimine structure with aminoacrylate and a-site iminopropionate intermediates (see paper)
50% identity, 99% coverage: 1:374/377 of query aligns to 2:380/381 of 4iyoB

query
sites
4iyoB

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active site: R47 (= R46), Y99 (= Y98), D172 (= D170), K197 (= K195)
binding 2-{[(E)-{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene]amino}prop-2-enoic acid: Y45 (= Y44), R47 (= R46)
binding amino-acrylate: Y99 (= Y98), K197 (= K195), S326 (= S320), T341 (≠ S335), R361 (= R355)
binding pyruvic acid: Q221 (≠ D218), F224 (= F221)
binding serine: Y45 (= Y44), T48 (= T47), Y99 (= Y98), R104 (= R103), N227 (= N224), E325 (= E319)

4iy7B Crystal structure of cystathionine gamma lyase (xometc) from xanthomonas oryzae pv. Oryzae in complex with e-site serine, a-site external aldimine structure with serine and a-site external aldimine structure with aminoacrylate intermediates (see paper)
50% identity, 99% coverage: 1:374/377 of query aligns to 2:380/381 of 4iy7B

query
sites
4iy7B

M

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F

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V

I

M

H

E

L

L

L

L

K

D

S

A

G

G

D

S

H

H

A

V

V

V

V

A

G

M

E

D

D

D

I

L

Y
|
Y

G

G

G

G

T

T

H

F

R
|
R

L

L

F

F

S

E

E

R

I

V

M

R

T

R

K

R

-

T

Y

A

G

G

I

L

D

D

F

F

T

S

F

F

I

V

R

D

M

L

D

T

S

D

E

P

E

A

K

A

L

F

E

K

A

A

A

A

I

I

K

R

P

A

N

D

T

T

K

K

M

M

I

V

W

W

I

I

E
|
E

T

T

P

P

S

T

N
|
N

P

P

L

M

L

L

N

K

I

L

T

V

D

D

L

I

S

A

M

A

V

I

S

A

K

V

I

I

A

A

K

R

E

K

K

H

Q

G

I

L

L

L

T

T

V

V

A

V

D
|
D

N

N

T

T

F

F

P

A

S

S

P

P

Y

M

F

L

L

Q

R

R

P

P

I

L

E

S

Y

L

G

G

I

A

D

D

L

L

V

V

L

V

H

H

S
|
S

T

A

T

T

K
|
K

Y

Y

I

L

N

N

G

G

H

H

S

S

D

D

V

M

I

V

G

G

G

G

-

I

A

A

I

V

V

V

T

G

T

D

T

N

E

A

E

E

L

L

A

A

K

E

D
x
Q

V

M

H

A

F
|
F

L

L

L

Q

N
|
N

G

S

M

I

G

G

T

G

N

V

A

Q

A

G

P

P

F

F

D

D

S

S

W

F

L

L

I

A

L

L

R

R

G

G

L

L

K

K

T

T

L

L

P

P

L

L

R

R

M

M

E

R

K

A

H

H

A

C

S

E

N

N

A

A

I

L

A

A

V

L

A

A

E

Q

Y

W

L

L

L

E

D

T

H

H

P

P

K

A

V

I

S

E

E

K

V

V

F

I

Y

Y

P

P

G

G

L

L

E

A

S

S

H

H

P

P

G

Q

H

H

S

V

I

L

A

A

K

K

N

R

Q

Q

M

M

D

S

G

G

Y

F

G

G

G

G

V

I

V

V

S

S

F

I

K

V

L

L

K

K

T

G

D

G

-

F

-

D

-

A

V

A

P

K

K

R

F

F

I

C

E

E

S

K

L

T

E

E

I

L

F

F

H

T

L

L

A

A

E
|
E

S
|
S

L
|
L

G

G

G

G

A

V

D

E

S

S

L

L

V

V

E

N

H

H

A

P

A

A

T

V

M

M

S
x
T

H

H

A

A

S

S

M

I

S

P

P

V

D

A

A

R

R

R

K

E

Q

Q

A

L

G

G

I

I

S

S

D

D

D

A

I

L

I

V

R
|
R

L

L

S

S

I

V

G

G

L

I

E

E

D

D

N

L

D

G

D

D

L

L

I

R

E

G

D

D

L

L

S

E

K

R

G

A

L

L

active site: R47 (= R46), Y99 (= Y98), D172 (= D170), K197 (= K195)
binding 2-{[(E)-{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene]amino}prop-2-enoic acid: Y45 (= Y44), R47 (= R46)
binding (E)-N-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)-L-serine: G75 (= G74), M76 (= M75), Y99 (= Y98), E143 (= E141), N147 (= N145), D172 (= D170), S194 (= S192), K197 (= K195), S326 (= S320), L327 (= L321), T341 (≠ S335), R361 (= R355)
binding pyruvic acid: Q221 (≠ D218), F224 (= F221)
binding serine: Y45 (= Y44), T48 (= T47), Y99 (= Y98), R104 (= R103), N227 (= N224), E325 (= E319)

4iy7A Crystal structure of cystathionine gamma lyase (xometc) from xanthomonas oryzae pv. Oryzae in complex with e-site serine, a-site external aldimine structure with serine and a-site external aldimine structure with aminoacrylate intermediates (see paper)
50% identity, 99% coverage: 1:374/377 of query aligns to 2:380/381 of 4iy7A

query
sites
4iy7A

M

L

K

S

F

L

S

A

T

T

R

L

S

A

I

I

H

H

A

G

G

G

R

Q

K

S

P

P

D

D

P

P

I

S

T

T

G

G

A

A

I

V

S

M

P

P

T

P

I

I

C

Y

Q

A

T

T

S

S

T

T

F

Y

T

A

F

Q

D

S

E

S

F

P

N

G

K

E

P

H

G

Q

D

G

Y

F

D

E

Y
|
Y

S

S

R
|
R

T
|
T

G

H

N

N

P

P

T

T

R

R

S

F

A

A

L

Y

E

E

E

R

A

C

I

V

A

A

N

A

L

L

E

E

G

G

G

G

N

T

A

R

G

A

F

F

C

A

F

F

S

A

S

S

G
|
G

M
|
M

A

A

A

A

V

T

T

S

T

T

A

V

I

M

H

E

L

L

L

L

K

D

S

A

G

G

D

S

H

H

A

V

V

V

V

A

G

M

E

D

D

D

I

L

Y
|
Y

G

G

G

G

T

T

H

F

R
|
R

L

L

F

F

S

E

E

R

I

V

M

R

T

R

K

R

-

T

Y

A

G

G

I

L

D

D

F

F

T

S

F

F

I

V

R

D

M

L

D

T

S

D

E

P

E

A

K

A

L

F

E

K

A

A

A

A

I

I

K

R

P

A

N

D

T

T

K

K

M

M

I

V

W

W

I

I

E
|
E

T

T

P

P

S

T

N
|
N

P

P

L

M

L

L

N

K

I

L

T

V

D

D

L

I

S

A

M

A

V

I

S

A

K

V

I

I

A

A

K

R

E

K

K

H

Q

G

I

L

L

L

T

T

V

V

A

V

D
|
D

N

N

T

T

F

F

P

A

S

S

P

P

Y

M

F

L

L

Q

R

R

P

P

I

L

E

S

Y

L

G

G

I

A

D

D

L

L

V

V

L

V

H

H

S
|
S

T

A

T

T

K
|
K

Y

Y

I

L

N

N

G

G

H

H

S

S

D

D

V

M

I

V

G

G

G

G

-

I

A

A

I

V

V

V

T

G

T

D

T

N

E

A

E

E

L

L

A

A

K

E

D

Q

V

M

H

A

F

F

L

L

L

Q

N
|
N

G

S

M

I

G

G

T

G

N

V

A

Q

A

G

P

P

F

F

D

D

S

S

W

F

L

L

I

A

L

L

R

R

G

G

L

L

K

K

T

T

L

L

P

P

L

L

R

R

M

M

E

R

K

A

H

H

A

C

S

E

N

N

A

A

I

L

A

A

V

L

A

A

E

Q

Y

W

L

L

L

E

D

T

H

H

P

P

K

A

V

I

S

E

E

K

V

V

F

I

Y

Y

P

P

G

G

L

L

E

A

S

S

H

H

P

P

G

Q

H

H

S

V

I

L

A

A

K

K

N

R

Q

Q

M

M

D

S

G

G

Y

F

G

G

G

G

V

I

V

V

S

S

F

I

K

V

L

L

K

K

T

G

D

G

-

F

-

D

-

A

V

A

P

K

K

R

F

F

I

C

E

E

S

K

L

T

E

E

I

L

F

F

H

T

L

L

A

A

E
|
E

S
|
S

L
|
L

G

G

G

G

A

V

D

E

S

S

L

L

V

V

E

N

H

H

A

P

A

A

T

V

M

M

S
x
T

H

H

A

A

S

S

M

I

S

P

P

V

D

A

A

R

R

R

K

E

Q

Q

A

L

G

G

I

I

S

S

D

D

D

A

I

L

I

V

R
|
R

L

L

S

S

I

V

G

G

L

I

E

E

D

D

N

L

D

G

D

D

L

L

I

R

E

G

D

D

L

L

S

E

K

R

G

A

L

L

active site: R47 (= R46), Y99 (= Y98), D172 (= D170), K197 (= K195)
binding 2-{[(E)-{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene]amino}prop-2-enoic acid: G75 (= G74), M76 (= M75), Y99 (= Y98), E143 (= E141), N147 (= N145), D172 (= D170), S194 (= S192), K197 (= K195), S326 (= S320), L327 (= L321), T341 (≠ S335), R361 (= R355)
binding (E)-N-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)-L-serine: Y45 (= Y44), R47 (= R46)
binding serine: Y45 (= Y44), T48 (= T47), Y99 (= Y98), R104 (= R103), N227 (= N224), E325 (= E319)

4ixzA Native structure of cystathionine gamma lyase (xometc) from xanthomonas oryzae pv. Oryzae at ph 9.0 (see paper)
50% identity, 99% coverage: 1:374/377 of query aligns to 2:380/381 of 4ixzA

query
sites
4ixzA

M

L

K

S

F

L

S

A

T

T

R

L

S

A

I

I

H

H

A

G

G

G

R

Q

K

S

P

P

D

D

P

P

I

S

T

T

G

G

A

A

I

V

S

M

P

P

T

P

I

I

C

Y

Q

A

T

T

S

S

T

T

F

Y

T

A

F

Q

D

S

E

S

F

P

N

G

K

E

P

H

G

Q

D

G

Y

F

D

E

Y

Y

S

S

R
|
R

T

T

G

H

N

N

P

P

T

T

R

R

S

F

A

A

L

Y

E

E

E

R

A

C

I

V

A

A

N

A

L

L

E

E

G

G

G

G

N

T

A

R

G

A

F

F

C

A

F

F

S

A

S

S

G

G

M

M

A

A

A

A

V

T

T

S

T

T

A

V

I

M

H

E

L

L

L

L

K

D

S

A

G

G

D

S

H

H

A

V

V

V

V

A

G

M

E

D

D

D

I

L

Y
|
Y

G

G

G

G

T

T

H

F

R

R

L

L

F

F

S

E

E

R

I

V

M

R

T

R

K

R

-

T

Y

A

G

G

I

L

D

D

F

F

T

S

F

F

I

V

R

D

M

L

D

T

S

D

E

P

E

A

K

A

L

F

E

K

A

A

A

A

I

I

K

R

P

A

N

D

T

T

K

K

M

M

I

V

W

W

I

I

E

E

T

T

P

P

S

T

N

N

P

P

L

M

L

L

N

K

I

L

T

V

D

D

L

I

S

A

M

A

V

I

S

A

K

V

I

I

A

A

K

R

E

K

K

H

Q

G

I

L

L

L

T

T

V

V

A

V

D
|
D

N

N

T

T

F

F

P

A

S

S

P

P

Y

M

F

L

L

Q

R

R

P

P

I

L

E

S

Y

L

G

G

I

A

D

D

L

L

V

V

L

V

H

H

S

S

T

A

T

T

K
|
K

Y

Y

I

L

N

N

G

G

H

H

S

S

D

D

V

M

I

V

G

G

G

G

-

I

A

A

I

V

V

V

T

G

T

D

T

N

E

A

E

E

L

L

A

A

K

E

D

Q

V

M

H

A

F

F

L

L

L

Q

N

N

G

S

M

I

G

G

T

G

N

V

A

Q

A

G

P

P

F

F

D

D

S

S

W

F

L

L

I

A

L

L

R

R

G

G

L

L

K

K

T

T

L

L

P

P

L

L

R

R

M

M

E

R

K

A

H

H

A

C

S

E

N

N

A

A

I

L

A

A

V

L

A

A

E

Q

Y

W

L

L

L

E

D

T

H

H

P

P

K

A

V

I

S

E

E

K

V

V

F

I

Y

Y

P

P

G

G

L

L

E

A

S

S

H

H

P

P

G

Q

H

H

S

V

I

L

A

A

K

K

N

R

Q

Q

M

M

D

S

G

G

Y

F

G

G

G

G

V

I

V

V

S

S

F

I

K

V

L

L

K

K

T

G

D

G

-

F

-

D

-

A

V

A

P

K

K

R

F

F

I

C

E

E

S

K

L

T

E

E

I

L

F

F

H

T

L

L

A

A

E

E

S
|
S

L
|
L

G

G

G

G

A

V

D

E

S

S

L

L

V

V

E

N

H

H

A

P

A

A

T

V

M

M

S
x
T

H

H

A

A

S

S

M

I

S

P

P

V

D

A

A

R

R

R

K

E

Q

Q

A

L

G

G

I

I

S

S

D

D

D

A

I

L

I

V

R
|
R

L

L

S

S

I

V

G

G

L

I

E

E

D

D

N

L

D

G

D

D

L

L

I

R

E

G

D

D

L

L

S

E

K

R

G

A

L

L

active site: R47 (= R46), Y99 (= Y98), D172 (= D170), K197 (= K195)
binding bicarbonate ion: Y99 (= Y98), S326 (= S320), L327 (= L321), T341 (≠ S335), R361 (= R355)

4iyoD Crystal structure of cystathionine gamma lyase from xanthomonas oryzae pv. Oryzae (xometc) in complex with e-site serine, a-site serine, a- site external aldimine structure with aminoacrylate and a-site iminopropionate intermediates (see paper)
50% identity, 99% coverage: 1:374/377 of query aligns to 2:380/384 of 4iyoD

query
sites
4iyoD

M

L

K

S

F

L

S

A

T

T

R

L

S

A

I

I

H

H

A

G

G

G

R

Q

K

S

P

P

D

D

P

P

I

S

T

T

G

G

A

A

I

V

S

M

P

P

T

P

I

I

C

Y

Q

A

T

T

S

S

T

T

F

Y

T

A

F

Q

D

S

E

S

F

P

N

G

K

E

P

H

G

Q

D

G

Y

F

D

E

Y
|
Y

S

S

R
|
R

T
|
T

G

H

N

N

P

P

T

T

R

R

S

F

A

A

L

Y

E

E

E

R

A

C

I

V

A

A

N

A

L

L

E

E

G

G

G

G

N

T

A

R

G

A

F

F

C

A

F

F

S

A

S

S

G

G

M

M

A

A

A

A

V

T

T

S

T

T

A

V

I

M

H

E

L

L

L

L

K

D

S

A

G

G

D

S

H

H

A

V

V

V

V

A

G

M

E

D

D

D

I

L

Y
|
Y

G

G

G

G

T

T

H

F

R
|
R

L

L

F

F

S

E

E

R

I

V

M

R

T

R

K

R

-

T

Y

A

G

G

I

L

D

D

F

F

T

S

F

F

I

V

R

D

M

L

D

T

S

D

E

P

E

A

K

A

L

F

E

K

A

A

A

A

I

I

K

R

P

A

N

D

T

T

K

K

M

M

I

V

W

W

I

I

E

E

T

T

P

P

S

T

N

N

P

P

L

M

L

L

N

K

I

L

T

V

D

D

L

I

S

A

M

A

V

I

S

A

K

V

I

I

A

A

K

R

E

K

K

H

Q

G

I

L

L

L

T

T

V

V

A

V

D
|
D

N

N

T

T

F

F

P

A

S

S

P

P

Y

M

F

L

L

Q

R

R

P

P

I

L

E

S

Y

L

G

G

I

A

D

D

L

L

V

V

L

V

H

H

S

S

T

A

T

T

K
|
K

Y

Y

I

L

N

N

G

G

H

H

S

S

D

D

V

M

I

V

G

G

G

G

-

I

A

A

I

V

V

V

T

G

T

D

T

N

E

A

E

E

L

L

A

A

K

E

D

Q

V

M

H

A

F

F

L

L

L

Q

N
|
N

G

S

M

I

G

G

T

G

N

V

A

Q

A

G

P

P

F

F

D

D

S

S

W

F

L

L

I

A

L

L

R

R

G

G

L

L

K

K

T

T

L

L

P

P

L

L

R

R

M

M

E

R

K

A

H

H

A

C

S

E

N

N

A

A

I

L

A

A

V

L

A

A

E

Q

Y

W

L

L

L

E

D

T

H

H

P

P

K

A

V

I

S

E

E

K

V

V

F

I

Y

Y

P

P

G

G

L

L

E

A

S

S

H

H

P

P

G

Q

H

H

S

V

I

L

A

A

K

K

N

R

Q

Q

M

M

D

S

G

G

Y

F

G

G

G

G

V

I

V

V

S

S

F

I

K

V

L

L

K

K

T

G

D

G

-

F

-

D

-

A

V

A

P

K

K

R

F

F

I

C

E

E

S

K

L

T

E

E

I

L

F

F

H

T

L

L

A

A

E
|
E

S
|
S

L

L

G

G

G

G

A

V

D

E

S

S

L

L

V

V

E

N

H

H

A

P

A

A

T

V

M

M

S
x
T

H

H

A

A

S

S

M

I

S

P

P

V

D

A

A

R

R

R

K

E

Q

Q

A

L

G

G

I

I

S

S

D

D

D

A

I

L

I

V

R
|
R

L

L

S

S

I

V

G

G

L

I

E

E

D

D

N

L

D

G

D

D

L

L

I

R

E

G

D

D

L

L

S

E

K

R

G

A

L

L

active site: R47 (= R46), Y99 (= Y98), D172 (= D170), K197 (= K195)
binding serine: Y45 (= Y44), T48 (= T47), Y99 (= Y98), Y99 (= Y98), R104 (= R103), K197 (= K195), N227 (= N224), E325 (= E319), S326 (= S320), T341 (≠ S335), R361 (= R355)

4l0oH Structure determination of cystathionine gamma-synthase from helicobacter pylori
50% identity, 99% coverage: 1:374/377 of query aligns to 1:370/373 of 4l0oH

query
sites
4l0oH

M

M

K

R

F

M

S

Q

T

T

R

K

S

L

I

I

H

H

A

G

G

G

R

I

K

S

P

E

D

D

P

A

I

T

T

T

G

G

A

A

I

V

S

S

P

V

T

P

I

I

C

Y

Q

Q

T

T

S

S

T

T

F

Y

T

R

F

Q

D

D

E

-

F

-

N

-

K

-

P

-

G

-

D

G

Y

Y

D

E

Y
|
Y

S

S

R
|
R

T

S

G

G

N

N

P

P

T

T

R

R

S

F

A

A

L

L

E

E

E

E

A

L

I

I

A

A

N

D

L

L

E

E

G

G

G

G

N

V

A

K

G

G

F

F

C

A

F

F

S

A

S
|
S

G
|
G

M
x
L

A

A

A

G

V

I

T

H

T

A

A

V

I

F

H

S

L

L

L

L

K

Q

S

S

G

G

D

D

H

H

A

V

V

L

V

L

G

G

E

D

D

D

I

V

Y
|
Y

G

G

G

G

T

T

H

F

R

R

L

L

F

F

S

N

E

Q

I

V

M

L

T

V

K

K

Y

N

G

G

I

L

D

S

F

C

T

T

F

I

I

I

R

D

M

T

D

S

S

D

E

I

E

S

K

Q

L

I

E

K

A

K

A

A

I

I

K

K

P

P

N

N

T

T

K

K

M

A

I

L

W

Y

I

L

E

E

T

T

P

P

S

S

N

N

P

P

L

L

L

L

N

K

I

I

T

T

D

D

L

L

S

A

M

Q

V

C

S

A

K

S

I

V

A

A

K

K

E

D

K

H

Q

G

I

L

L

L

T

T

V

I

A

V

D
|
D

N

N

T

T

F

F

P

A

S

T

P

P

Y

Y

F

Y

L

Q

R

N

P

P

I

L

E

L

Y

L

G

G

I

A

D

D

L

I

V

V

L

A

H

H

S
|
S

T

G

T
|
T

K
|
K

Y

Y

I

L

N

G

G

G

H

H

S

S

D

D

V

V

I

V

G

A

G

G

A

L

I

V

V

T

T

T

T

N

T

N

E

E

E

A

L

L

A

A

K

Q

D

E

V

I

H

A

F

F

L

F

L

Q

N

N

G

A

M

I

G

G

T

G

N

V

A

L

A

G

P

P

F

Q

D

D

S

S

W

W

L

L

I

L

L

Q

R

R

G

G

L

I

K

K

T

T

L

L

P

G

L

L

R

R

M

M

E

E

K

A

H

H

A

Q

S

K

N

N

A

A

I

L

A

C

V

V

A

A

E

E

Y

F

L

L

L

E

D

K

H

H

P

P

K

K

V

V

S

E

E

R

V

V

F

Y

Y

Y

P

P

G

G

L

L

E

P

S

T

H

H

P

P

G

N

H

Y

S

E

I

L

A

A

K

K

N

K

Q

Q

M

M

D

R

G

G

Y

F

G

S

G

G

V

M

V

L

S

S

F

F

K

T

L

L

K

K

T

N

D

D

-

S

-

E

V

A

P

V

K

A

F

F

I

V

E

E

S

S

L

L

E

K

I

L

F

F

H

I

L

L

A

G

E

E

S

S

L

L

G

G

G

G

A

V

D

E

S

S

L

L

V

V

E

G

H

I

A

P

A

A

T

F

M

M

S

T

H

H

A

A

S

C

M

I

S

P

P

K

D

T

A

Q

R

R

K

E

Q

A

A

A

G

G

I

I

S

R

D

D

D

G

I

L

I

V

R

R

L

L

S

S

I

V

G

G

L

I

E

E

D

H

N

E

D

Q

D

D

L

L

I

L

E

E

D

D

L

L

S

E

K

Q

G

A

L

F

active site: R40 (= R46), Y92 (= Y98), D164 (= D170), K189 (= K195)
binding pyridoxal-5'-phosphate: Y38 (= Y44), R40 (= R46), S67 (= S73), G68 (= G74), L69 (≠ M75), Y92 (= Y98), D164 (= D170), S186 (= S192), T188 (= T194), K189 (= K195)

4ixsB Native structure of xometc at ph 5.2 (see paper)
50% identity, 99% coverage: 1:374/377 of query aligns to 1:371/372 of 4ixsB

query
sites
4ixsB

M

L

K

S

F

L

S

A

T

T

R

L

S

A

I

I

H

H

A

G

G

G

R

Q

K

S

P

P

D

D

P

P

I

S

T

T

G

G

A

A

I

V

S

M

P

P

T

P

I

I

C

Y

Q

A

T

T

S

S

T

T

F

Y

T

-

F

-

D

-

E

-

F

-

N

-

K

-

P

-

G

A

D

Q

Y

S

D

S

Y

P

S

S

R
|
R

T

T

G

H

N

N

P

P

T

T

R

R

S

F

A

A

L

Y

E

E

E

R

A

C

I

V

A

A

N

A

L

L

E

E

G

G

G

G

N

T

A

R

G

A

F

F

C

A

F

F

S

A

S

S

G

G

M

M

A

A

A

A

V

T

T

S

T

T

A

V

I

M

H

E

L

L

L

L

K

D

S

A

G

G

D

S

H

H

A

V

V

V

V

A

G

M

E

D

D

D

I

L

Y
|
Y

G

G

G

G

T

T

H

F

R

R

L

L

F

F

S

E

E

R

I

V

M

R

T

R

K

R

-

T

Y

A

G

G

I

L

D

D

F

F

T

S

F

F

I

V

R

D

M

L

D

T

S

D

E

P

E

A

K

A

L

F

E

K

A

A

A

A

I

I

K

R

P

A

N

D

T

T

K

K

M

M

I

V

W

W

I

I

E

E

T

T

P

P

S

T

N

N

P

P

L

M

L

L

N

K

I

L

T

V

D

D

L

I

S

A

M

A

V

I

S

A

K

V

I

I

A

A

K

R

E

K

K

H

Q

G

I

L

L

L

T

T

V

V

A

V

D
|
D

N

N

T

T

F

F

P

A

S

S

P

P

Y

M

F

L

L

Q

R

R

P

P

I

L

E

S

Y

L

G

G

I

A

D

D

L

L

V

V

L

V

H

H

S

S

T

A

T

T

K
|
K

Y

Y

I

L

N

N

G

G

H

H

S

S

D

D

V

M

I

V

G

G

G

G

-

I

A

A

I

V

V

V

T

G

T

D

T

N

E

A

E

E

L

L

A

A

K

E

D

Q

V

M

H

A

F

F

L

L

L

Q

N

N

G

S

M

I

G

G

T

G

N

V

A

Q

A

G

P

P

F

F

D

D

S

S

W

F

L

L

I

A

L

L

R

R

G

G

L

L

K

K

T

T

L

L

P

P

L

L

R

R

M

M

E

R

K

A

H

H

A

C

S

E

N

N

A

A

I

L

A

A

V

L

A

A

E

Q

Y

W

L

L

L

E

D

T

H

H

P

P

K

A

V

I

S

E

E

K

V

V

F

I

Y

Y

P

P

G

G

L

L

E

A

S

S

H

H

P

P

G

Q

H

H

S

V

I

L

A

A

K

K

N

R

Q

Q

M

M

D

S

G

G

Y

F

G

G

G

G

V

I

V

V

S

S

F

I

K

V

L

L

K

K

T

G

D

G

-

F

-

D

-

A

V

A

P

K

K

R

F

F

I

C

E

E

S

K

L

T

E

E

I

L

F

F

H

T

L

L

A

A

E
|
E

S
|
S

L

L

G

G

G

G

A

V

D

E

S

S

L

L

V

V

E

N

H

H

A

P

A

A

T

V

M

M

S
x
T

H

H

A

A

S

S

M

I

S

P

P

V

D

A

A

R

R

R

K

E

Q

Q

A

L

G

G

I

I

S

S

D

D

D

A

I

L

I

V

R
|
R

L

L

S

S

I

V

G

G

L

I

E

E

D

D

N

L

D

G

D

D

L

L

I

R

E

G

D

D

L

L

S

E

K

R

G

A

L

L

active site: R38 (= R46), Y90 (= Y98), D163 (= D170), K188 (= K195)
binding carbonate ion: K188 (= K195), E316 (= E319), S317 (= S320), T332 (≠ S335), R352 (= R355)

6k1lB E53a mutant of a putative cystathionine gamma-lyase (see paper)
51% identity, 99% coverage: 1:374/377 of query aligns to 3:381/382 of 6k1lB

query
sites
6k1lB

M

L

K

A

F

L

S

A

T

T

R

L

S

A

I

I

H

H

A

G

G

G

R

Q

K

S

P

P

D

D

P

P

I

S

T

T

G

G

A

A

I

V

S

M

P

P

T

P

I

I

C

Y

Q

A

T

T

S

S

T

T

F

Y

T

A

F

Q

D

S

E

S

F

P

N

G

K

E

P

H

G

Q

D

G

Y

F

D

A

Y
|
Y

S

S

R
|
R

T

T

G

H

N

N

P

P

T

T

R

R

S

F

A

A

L

Y

E

E

E

R

A

C

I

V

A

A

N

S

L

L

E

E

G

G

G

G

N

T

A

R

G

G

F

F

C

A

F

F

S

A

S
|
S

G
|
G

M
|
M

A

A

A

A

V

S

T

S

T

T

A

V

I

I

H

E

L

L

L

L

K

D

S

A

G

G

D

S

H

H

A

V

V

V

V

A

G

M

E

D

D

D

I

I

Y
|
Y

G

G

G

G

T

S

H

F

R

R

L

L

F

F

S

E

E

R

I

V

M

R

T

R

K

R

-

T

Y

A

G

G

I

L

D

D

F

F

T

S

F

F

I

V

R

D

M

L

D

T

S

D

E

L

E

A

K

A

L

F

E

E

A

A

A

S

I

I

K

T

P

P

N

K

T

T

K

K

M

M

I

V

W

W

I

I

E

E

T

T

P

P

S

T

N

N

P

P

L

M

L

L

N

K

I

I

T

V

D

D

L

I

S

A

M

A

V

V

S

A

K

A

I

I

A

A

K

K

E

R

K

H

Q

G

I

L

L

I

T

V

V

V

A

V

D
|
D

N

N

T

T

F

F

P

A

S

S

P

P

Y

M

F

L

L

Q

R

R

P

P

I

L

E

E

Y

L

G

G

I

A

D

D

L

L

V

V

L

L

H

H

S
|
S

T

A

T

T

K
|
K

Y

Y

I

L

N

N

G

G

H

H

S

S

D

D

V

M

I

V

G

G

G

G

A

M

I

V

V

V

T

V

-

G

T

D

T

N

E

A

E

E

L

L

A

A

K

E

D

Q

V

M

H

A

F

F

L

L

L

Q

N

N

G

S

M

V

G

G

T

G

N

V

A

Q

A

G

P

P

F

F

D

D

S

S

W

F

L

L

I

A

L

L

R

R

G

G

L

L

K

K

T

T

L

L

P

P

L

L

R

R

M

M

E

K

K

A

H

H

A

C

S

A

N

N

A

A

I

L

A

A

V

L

A

A

E

Q

Y

W

L

L

L

E

D

K

H

H

P

P

K

A

V

V

S

E

E

K

V

V

F

I

Y

Y

P

P

G

G

L

L

E

A

S

S

H

H

P

P

G

Q

H

H

S

E

I

L

A

A

K

G

N

K

Q

Q

M

M

D

A

G

G

Y

Y

G

G

G

G

V

I

V

V

S

S

F

I

K

V

L

L

K

K

T

G

D

G

-

F

-

D

-

A

V

A

P

K

K

R

F

F

I

C

E

E

S

K

L

T

E

E

I

L

F

F

H

T

L

L

A

A

E
|
E

S

S

L

L

G

G

G

G

A

V

D

E

S

S

L

L

V

V

E

N

H

H

A

P

A

A

T

V

M

M

S
x
T

H

H

A

A

S

S

M

I

S

P

P

V

D

A

A

R

R

R

K

E

Q

Q

A

L

G

G

I

I

S

S

D

D

D

A

I

L

I

V

R
|
R

L

L

S

S

I

V

G

G

L

V

E

E

D

D

N

L

D

G

D

D

L

L

I

Q

E

V

D

D

L

L

S

G

K

E

G

A

L

L

binding pyridoxal-5'-phosphate: Y46 (= Y44), R48 (= R46), S75 (= S73), G76 (= G74), M77 (= M75), Y100 (= Y98), D173 (= D170), S195 (= S192), K198 (= K195)
binding pyruvic acid: Y100 (= Y98), K198 (= K195), E326 (= E319), T342 (≠ S335), R362 (= R355)

6k1lA E53a mutant of a putative cystathionine gamma-lyase (see paper)
51% identity, 99% coverage: 1:374/377 of query aligns to 3:381/382 of 6k1lA

query
sites
6k1lA

M

L

K

A

F

L

S

A

T

T

R

L

S

A

I

I

H

H

A

G

G

G

R

Q

K

S

P

P

D

D

P

P

I

S

T

T

G

G

A

A

I

V

S

M

P

P

T

P

I

I

C

Y

Q

A

T

T

S

S

T

T

F

Y

T

A

F

Q

D

S

E

S

F

P

N

G

K

E

P

H

G

Q

D

G

Y

F

D

A

Y
|
Y

S

S

R
|
R

T

T

G

H

N

N

P

P

T

T

R

R

S

F

A

A

L

Y

E

E

E

R

A

C

I

V

A

A

N

S

L

L

E

E

G

G

G

G

N

T

A

R

G

G

F

F

C

A

F

F

S

A

S

S

G
|
G

M
|
M

A

A

A

A

V

S

T

S

T

T

A

V

I

I

H

E

L

L

L

L

K

D

S

A

G

G

D

S

H

H

A

V

V

V

V

A

G

M

E

D

D

D

I

I

Y
|
Y

G

G

G

G

T

S

H

F

R

R

L

L

F

F

S

E

E

R

I

V

M

R

T

R

K

R

-

T

Y

A

G

G

I

L

D

D

F

F

T

S

F

F

I

V

R

D

M

L

D

T

S

D

E

L

E

A

K

A

L

F

E

E

A

A

A

S

I

I

K

T

P

P

N

K

T

T

K

K

M

M

I

V

W

W

I

I

E

E

T

T

P

P

S

T

N

N

P

P

L

M

L

L

N

K

I

I

T

V

D

D

L

I

S

A

M

A

V

V

S

A

K

A

I

I

A

A

K

K

E

R

K

H

Q

G

I

L

L

I

T

V

V

V

A

V

D
|
D

N

N

T

T

F

F

P

A

S

S

P

P

Y

M

F

L

L

Q

R

R

P

P

I

L

E

E

Y

L

G

G

I

A

D

D

L

L

V

V

L

L

H

H

S
|
S

T

A

T
|
T

K
|
K

Y

Y

I

L

N

N

G

G

H

H

S

S

D

D

V

M

I

V

G

G

G

G

A

M

I

V

V

V

T

V

-

G

T

D

T

N

E

A

E

E

L

L

A

A

K

E

D

Q

V

M

H

A

F

F

L

L

L

Q

N

N

G

S

M

V

G

G

T

G

N

V

A

Q

A

G

P

P

F

F

D

D

S

S

W

F

L

L

I

A

L

L

R

R

G

G

L

L

K

K

T

T

L

L

P

P

L

L

R

R

M

M

E

K

K

A

H

H

A

C

S

A

N

N

A

A

I

L

A

A

V

L

A

A

E

Q

Y

W

L

L

L

E

D

K

H

H

P

P

K

A

V

V

S

E

E

K

V

V

F

I

Y

Y

P

P

G

G

L

L

E

A

S

S

H

H

P

P

G

Q

H

H

S

E

I

L

A

A

K

G

N

K

Q

Q

M

M

D

A

G

G

Y

Y

G

G

G

G

V

I

V

V

S

S

F

I

K

V

L

L

K

K

T

G

D

G

-

F

-

D

-

A

V

A

P

K

K

R

F

F

I

C

E

E

S

K

L

T

E

E

I

L

F

F

H

T

L

L

A

A

E

E

S

S

L

L

G

G

G

G

A

V

D

E

S

S

L

L

V

V

E

N

H

H

A

P

A

A

T

V

M

M

S

T

H

H

A

A

S

S

M

I

S

P

P

V

D

A

A

R

R

R

K

E

Q

Q

A

L

G

G

I

I

S

S

D

D

D

A

I

L

I

V

R

R

L

L

S

S

I

V

G

G

L

V

E

E

D

D

N

L

D

G

D

D

L

L

I

Q

E

V

D

D

L

L

S

G

K

E

G

A

L

L

binding pyridoxal-5'-phosphate: Y46 (= Y44), R48 (= R46), G76 (= G74), M77 (= M75), Y100 (= Y98), D173 (= D170), S195 (= S192), T197 (= T194), K198 (= K195)

6cjaA Crystal structure of cystathionine beta-lyase from legionella pneumophila philadelphia 1 in complex with alanyl-plp and serine
51% identity, 99% coverage: 3:374/377 of query aligns to 4:380/381 of 6cjaA

query
sites
6cjaA

F

F

S

D

T

T

R

R

S

A

I

I

H

H

A

A

G

G

R

Q

K

E

P

P

D

C

P

K

I

S

T

T

G

G

A

A

I

V

S

M

P

T

T

P

I

I

C

Y

Q

A

T

T

S

S

T

T

F

Y

T

-

F

-

D

-

E

K

F

Q

N

I

K

A

P

P

G

G

D

E

-

H

-

L

-

G

Y

Y

D
x
E

Y
|
Y

S

S

R
|
R

T
|
T

G

Q

N

N

P

P

T

T

R

R

S

K

A

A

L

Y

E

E

E

D

A

C

I

I

A

A

N

S

L

L

E

E

G

S

G

G

N

Q

A

K

G

G

F

F

C

A

F

F

S

A

S
|
S

G
|
G

M
|
M

A

A

A

A

V

I

T

N

T

T

A

V

I

I

H

D

L

L

L

L

K

G

S

S

G

G

D

D

H

H

A

V

V

V

V

A

G

M

E

D

D

D

I

L

Y
|
Y

G

G

G

G

T

T

H

F

R
|
R

L

L

F

F

S

D

E

K

I

V

M

K

T

T

K

R

Y

T

-

S

G

N

I

L

D

S

F

F

T

S

F

F

I

I

R

D

M

M

D

S

S

V

E

P

E

E

K

N

L

I

E

E

A

A

A

A

I

I

K

T

P

P

N

K

T

T

K

K

M

L

I

L

W

W

I

L

E

E

T

T

P

P

S

S

N
|
N

P

P

L

M

L

L

N

K

I

L

T

A

D

N

L

L

S

R

M

K

V

I

S

A

K

A

I

I

A

A

K

K

E

K

K

Y

Q

N

I

L

L

I

T

T

V

V

A

A

D
|
D

N

N

T

T

F

F

P

A

S

T

P

P

Y

W

F

I

L

Q

R

R

P

P

I

L

E

E

Y

L

G

G

I

F

D

D

L

I

V

V

L

L

H

H

S
|
S

T

A

T
|
T

K
|
K

Y

Y

I

L

N

N

G

G

H

H

S

S

D

D

V

V

I

V

G

S

G

G

A

V

I

V

V

V

T

V

T

G

T

D

E

N

E

S

L

V

A

L

K

S

D

D

-

K

V

I

H

A

F

F

L

L

L

Q

N

N

G

S

M

C

G

G

T

A

N

V

A

A

A

G

P

P

F

F

D

D

S

S

W

F

L

L

I

V

L

L

R

R

G

S

L

L

K

K

T

T

L

L

P

S

L

V

R

R

M

M

E

Q

K

R

H

H

A

C

S

E

N

N

A

A

I

N

A

H

V

L

A

A

E

N

Y

W

L

L

L

S

D

S

H

H

P

P

K

K

V

I

S

E

E

K

V

V

F

I

Y

Y

P

P

G

G

L

L

E

K

S

S

H

H

P

P

G

Q

H

Y

S

S

I

L

A

A

K

K

N

E

Q

Q

M

M

D

N

G

N

Y

F

G

G

G

G

V

M

V

I

S

S

F

L

K