SitesBLAST
Comparing WP_013645612.1 NCBI__GCF_000191585.1:WP_013645612.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
5nofA Anthranilate phosphoribosyltransferase from thermococcus kodakaraensis (see paper)
41% identity, 96% coverage: 5:339/348 of query aligns to 3:316/325 of 5nofA
4yi7A Anthranilate bound at active site of anthranilate phosphoribosyl transferase from acinetobacter (anprt; trpd)
39% identity, 99% coverage: 2:346/348 of query aligns to 4:326/331 of 4yi7A
2gvqD Anthranilate phosphoribosyl-transferase (trpd) from s. Solfataricus in complex with anthranilate (see paper)
37% identity, 99% coverage: 2:346/348 of query aligns to 3:330/345 of 2gvqD
P50384 Anthranilate phosphoribosyltransferase; EC 2.4.2.18 from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus) (see 2 papers)
37% identity, 99% coverage: 2:346/348 of query aligns to 3:330/345 of P50384
- T87 (= T89) binding 5-phospho-alpha-D-ribose 1-diphosphate
- K106 (= K109) mutation to Q: Affinity for phosphoribosylpyrophosphate is similar to that of the wild-type enzyme and catalytic efficiency dedreases only 10-fold.
- H107 (= H110) mutation to A: Limited effect on either affinity for anthranilate and catalytic efficiency. 300-fold decrease of the affinity for anthranilate, whereas catalytic efficiency remains nearly unchanged; when associated with A-178.
- S118 (≠ G121) binding 5-phospho-alpha-D-ribose 1-diphosphate
- H154 (= H157) mutation to A: Limited effect on either affinity for anthranilate and catalytic efficiency.
- R164 (= R167) mutation to A: Strong decrease of the affinity for anthranilate, although only a moderate 7-fold decrease in catalytic efficiency.
- D223 (= D231) mutation to N: Affinity for phosphoribosylpyrophosphate is similar to that of the wild-type enzyme and catalytic efficiency is unchanged.
- E224 (= E232) mutation to Q: Affinity for phosphoribosylpyrophosphate is similar to that of the wild-type enzyme and catalytic efficiency is unchanged.
1zxyA Anthranilate phosphoribosyltransferase from sulfolobus solfataricus in complex with prpp and magnesium (see paper)
37% identity, 99% coverage: 2:346/348 of query aligns to 3:330/344 of 1zxyA
- binding magnesium ion: D223 (= D231), E224 (= E232)
- binding 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose: A78 (≠ C80), G79 (= G81), D83 (= D85), T87 (= T89), N89 (= N91), S91 (= S93), T92 (= T94), K106 (= K109), S118 (≠ G121), D223 (= D231), E224 (= E232)
1kgzB Crystal structure analysis of the anthranilate phosphoribosyltransferase from erwinia carotovora (current name, pectobacterium carotovorum) (see paper)
35% identity, 96% coverage: 6:339/348 of query aligns to 6:324/330 of 1kgzB
- binding manganese (ii) ion: S92 (= S93), D222 (= D231), E223 (= E232), E223 (= E232)
- binding 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose: V79 (≠ C80), G82 (= G83), G83 (= G84), N90 (= N91), I91 (= I92), S92 (= S93), T93 (= T94), K108 (= K109), S118 (≠ G121)
1gxbA Anthranilate phosphoribosyltransferase in complex with pyrophosphate and magnesium (see paper)
36% identity, 99% coverage: 2:346/348 of query aligns to 3:326/339 of 1gxbA
3gbrA Anthranilate phosphoribosyl-transferase (trpd) double mutant d83g f149s from s. Solfataricus (see paper)
36% identity, 99% coverage: 2:346/348 of query aligns to 3:327/341 of 3gbrA
- binding manganese (ii) ion: S91 (= S93), D220 (= D231), E221 (= E232), E221 (= E232)
- binding 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose: A78 (≠ C80), G79 (= G81), T80 (= T82), G81 (= G83), N89 (= N91), V90 (≠ I92), S91 (= S93), T92 (= T94), K106 (= K109), G114 (= G120)
4zokA Methylsulfonyl-containing inhibitor bound in the substrate capture site of mycobacterium tuberculosis anthranilate phosphoribosyltransferase (anprt; trpd)
34% identity, 99% coverage: 4:348/348 of query aligns to 5:342/342 of 4zokA
- active site: V82 (≠ C80)
- binding 4-methyl-2-{[2-methyl-6-(methylsulfonyl)phenyl]amino}benzoic acid: P156 (= P154), R163 (≠ K161), A166 (≠ M164), A167 (≠ P165)
- binding magnesium ion: S95 (= S93), E228 (= E232)
- binding 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose: G86 (= G84), N93 (= N91), S95 (= S93), T96 (= T94), K111 (= K109), A116 (≠ S114), A117 (≠ I115), S119 (= S117), G122 (= G120)
4zofA Lobenzarit-like inhibitor bound in the active site of mycobacterium tuberculosis anthranilate phosphoribosyltransferase (anprt; trpd)
34% identity, 99% coverage: 4:348/348 of query aligns to 5:342/342 of 4zofA
- active site: V82 (≠ C80)
- binding 2-[(2-carboxy-5-nitrophenyl)amino]-3-methylbenzoic acid: G113 (= G111), N114 (= N112), A155 (= A153), H159 (= H157), Y162 (≠ M160), R169 (= R167), G182 (= G180)
- binding magnesium ion: S95 (= S93), D227 (= D231), E228 (= E232), E228 (= E232)
- binding 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose: G83 (= G81), G85 (= G83), G86 (= G84), N93 (= N91), S95 (= S93), T96 (= T94), K111 (= K109), A116 (≠ S114), A117 (≠ I115), S119 (= S117), G122 (= G120)
4zojA Methylsulfanyl-containing inhibitor bound in the active site of mycobacterium tuberculosis anthranilate phosphoribosyltransferase (anprt; trpd)
33% identity, 99% coverage: 4:348/348 of query aligns to 5:341/341 of 4zojA
- active site: V82 (≠ C80)
- binding 4-methyl-2-{[2-methyl-6-(methylsulfanyl)phenyl]amino}benzoic acid: N114 (= N112), A155 (= A153), P156 (= P154), H159 (= H157), Y162 (≠ M160), R169 (= R167), G182 (= G180)
- binding magnesium ion: S95 (= S93), D227 (= D231), E228 (= E232), E228 (= E232)
- binding 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose: G83 (= G81), G85 (= G83), G86 (= G84), N93 (= N91), S95 (= S93), T96 (= T94), K111 (= K109), R115 (= R113), A116 (≠ S114), A117 (≠ I115), S119 (= S117)
5c7sA Prpp complexed with two mn2+ in the active site of mycobacterium tuberculosis anthranilate phosphoribosyltransferase (anprt; trpd)
33% identity, 99% coverage: 4:348/348 of query aligns to 6:344/344 of 5c7sA
- active site: V83 (≠ C80)
- binding manganese (ii) ion: G84 (= G81), S96 (= S93), D228 (= D231), E229 (= E232), E229 (= E232)
- binding 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose: V83 (≠ C80), G84 (= G81), G86 (= G83), G87 (= G84), N94 (= N91), S96 (= S93), T97 (= T94), K112 (= K109), N115 (= N112), S120 (= S117)
5c1rA Stereoisomer of prpp bound in the active site of mycobacterium tuberculosis anthranilate phosphoribosyl (anprt; trpd)
33% identity, 99% coverage: 4:348/348 of query aligns to 5:343/343 of 5c1rA
- active site: V82 (≠ C80)
- binding 5-O-[(R)-hydroxy(phosphonooxy)phosphoryl]-1-O-phosphono-alpha-D-ribofuranose: V82 (≠ C80), G83 (= G81), G86 (= G84), N93 (= N91), S95 (= S93), T96 (= T94), K111 (= K109), R115 (= R113), A117 (≠ I115), S118 (≠ T116), S119 (= S117)
- binding magnesium ion: D87 (= D85), V89 (≠ L87), S95 (= S93), E228 (= E232)
3r88B Anthranilate phosphoribosyltransferase (trpd) from mycobacterium tuberculosis (complex with inhibitor acs145) (see paper)
33% identity, 99% coverage: 4:348/348 of query aligns to 5:343/344 of 3r88B
- active site: V82 (≠ C80)
- binding 2-amino-4,5-dimethoxybenzoic acid: N114 (= N112), A155 (= A153), P156 (= P154), H159 (= H157), Y162 (≠ M160), R163 (≠ K161), A166 (≠ M164)
- binding magnesium ion: S95 (= S93), D227 (= D231), E228 (= E232), E228 (= E232)
- binding 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose: V82 (≠ C80), G83 (= G81), G85 (= G83), G86 (= G84), N93 (= N91), S95 (= S93), T96 (= T94), K111 (= K109), N114 (= N112), A117 (≠ I115), S118 (≠ T116), S119 (= S117)
P9WFX5 Anthranilate phosphoribosyltransferase; EC 2.4.2.18 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
34% identity, 99% coverage: 4:348/348 of query aligns to 29:369/370 of P9WFX5
- G107 (= G81) binding 5-phospho-alpha-D-ribose 1-diphosphate
- T115 (= T89) binding 5-phospho-alpha-D-ribose 1-diphosphate
- G147 (= G121) binding 5-phospho-alpha-D-ribose 1-diphosphate
5c2lA Magnesium soaked into the active site of mycobacterium tuberculosis anthranilate phosphoribosyltransferase (anprt; trpd)
34% identity, 99% coverage: 4:348/348 of query aligns to 7:347/349 of 5c2lA
4n93A Alternative substrates of mycobacterium tuberculosis anthranilate phosphoribosyl transferase (see paper)
33% identity, 99% coverage: 4:348/348 of query aligns to 6:345/346 of 4n93A
- active site: V83 (≠ C80)
- binding 2-amino-6-methylbenzoic acid: V83 (≠ C80), G84 (= G81), T85 (= T82), H113 (= H110), N115 (= N112), N115 (= N112), A156 (= A153), P157 (= P154), H160 (= H157), Y163 (≠ M160), A167 (≠ M164), R170 (= R167), G183 (= G180), P184 (= P181)
- binding magnesium ion: S96 (= S93), D228 (= D231), E229 (= E232), E229 (= E232)
- binding 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose: G84 (= G81), G86 (= G83), G87 (= G84), N94 (= N91), S96 (= S93), T97 (= T94), K112 (= K109), A117 (≠ S114), A118 (≠ I115), S120 (= S117), G123 (= G120)
4owoA Anthranilate phosphoribosyl transferase from mycobacterium tuberculosis in complex with 6-fluoroanthranilate, prpp and magnesium (see paper)
34% identity, 99% coverage: 4:348/348 of query aligns to 7:347/348 of 4owoA
- active site: V84 (≠ C80)
- binding 2-azanyl-6-fluoranyl-benzoic acid: V84 (≠ C80), G85 (= G81), T86 (= T82), H114 (= H110), N116 (= N112), N116 (= N112), A157 (= A153), P158 (= P154), H161 (= H157), Y164 (≠ M160), A168 (≠ M164), R171 (= R167), G184 (= G180)
- binding magnesium ion: S97 (= S93), D229 (= D231), E230 (= E232), E230 (= E232)
- binding 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose: V84 (≠ C80), G85 (= G81), G87 (= G83), G88 (= G84), N95 (= N91), S97 (= S93), T98 (= T94), K113 (= K109), A118 (≠ S114), A119 (≠ I115), S120 (≠ T116), S121 (= S117), G124 (= G120)
4n5vA Alternative substrates of mycobacterium tuberculosis anthranilate phosphoribosyl transferase (see paper)
33% identity, 99% coverage: 4:348/348 of query aligns to 7:346/347 of 4n5vA
- active site: V84 (≠ C80)
- binding 2-amino-4-fluorobenzoic acid: V84 (≠ C80), G85 (= G81), H114 (= H110), G115 (= G111), N116 (= N112), A157 (= A153), A157 (= A153), P158 (= P154), H161 (= H157), Y164 (≠ M160), R165 (≠ K161), A168 (≠ M164), R171 (= R167), G184 (= G180)
- binding magnesium ion: S97 (= S93), D229 (= D231), E230 (= E232), E230 (= E232)
- binding 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose: G85 (= G81), G87 (= G83), G88 (= G84), N95 (= N91), S97 (= S93), T98 (= T94), K113 (= K109), A119 (≠ I115), S120 (≠ T116), S121 (= S117), G124 (= G120)
4giuA Bianthranilate-like analogue bound in inner site of anthranilate phosphoribosyltransferase (anprt; trpd). (see paper)
34% identity, 99% coverage: 4:348/348 of query aligns to 6:346/346 of 4giuA
- active site: V83 (≠ C80)
- binding 2-[(2-carboxy-5-methylphenyl)amino]-3-methylbenzoic acid: G114 (= G111), N115 (= N112), A156 (= A153), H160 (= H157), Y163 (≠ M160), R170 (= R167), G183 (= G180)
- binding magnesium ion: S96 (= S93), D228 (= D231), E229 (= E232), E229 (= E232)
- binding 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose: G84 (= G81), G86 (= G83), G87 (= G84), N94 (= N91), S96 (= S93), T97 (= T94), K112 (= K109), N115 (= N112), A117 (≠ S114), A118 (≠ I115), S119 (≠ T116), S120 (= S117), G123 (= G120)
Query Sequence
>WP_013645612.1 NCBI__GCF_000191585.1:WP_013645612.1
MISECLKKVVAGNDLTQDEAYTSMMEMTSGEAGEIRTAAFLTALSMKGETADEITGFVKA
MRELCIEVSPETDLPLVDTCGTGGDRLKTFNISTTAAIIAAASDVAIAKHGNRSITSKCG
GADILEALGVNINCDKSSVERCIETCKISFIFAPNFHPSMKRIMPVRQELGIRTVFNILG
PLTSPANADIQLLGVFDPEYVEIIADVLKNLDVKHAMVVHGFDENDDPAMDEISTIGKTR
VAILENGRVTVKDIYPEDFGVKRSKSRFIRAPETIEENIQVVKDVLSGKNSTTEERAKLD
MCLVNAAAILYIAGQADSLKMGYQNAYATVKSGRALEKLGSFIEISNN
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory