SitesBLAST

C54 (= C52) mutation to A: Loss of activity. Cannot grow on sulfide-only medium.
C131 (= C128) active site, Cysteine persulfide intermediate; mutation to A: Can grow on sulfide-only medium.

Q57564 L-aspartate semialdehyde sulfurtransferase; EC 2.8.1.16 from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) (see paper)
56% identity, 100% coverage: 1:488/490 of query aligns to 3:505/509 of Q57564

query
sites
Q57564

M

M

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K

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N

N

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S395 (≠ T379) binding
I399 (= I382) binding
H421 (= H404) binding
D439 (= D421) binding
T456 (= T439) binding
I460 (= I443) binding
NISG 479:482 (≠ NISA 462:465) binding
TSED 497:500 (= TSED 480:483) binding

3kpcA Crystal structure of the cbs domain pair of protein mj0100 in complex with 5 -methylthioadenosine and s-adenosyl-l-methionine (see paper)
53% identity, 24% coverage: 371:488/490 of query aligns to 2:120/124 of 3kpcA

query
sites
3kpcA

V

I

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T

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L

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x
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x
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L

L

F

binding 5'-deoxy-5'-methylthioadenosine: S10 (≠ T379), I14 (= I382), I34 (≠ V402), N35 (= N403), H36 (= H404), I110 (≠ M478), T112 (= T480), E114 (= E482), D115 (= D483)
binding s-adenosylmethionine: I49 (= I416), W53 (= W420), D54 (= D421), T71 (= T439), V74 (= V442), I75 (= I443), N94 (= N462), I95 (= I463), S96 (= S464), G97 (≠ A465)

3lfzA Crystal structure of protein mj1225 from methanocaldococcus jannaschii, a putative archaeal homolog of g-ampk. (see paper)
38% identity, 21% coverage: 386:486/490 of query aligns to 163:277/280 of 3lfzA

query
sites
3lfzA

P

P

E

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D

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N

G

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x
F

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x
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x
R

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L

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N

N

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G

A

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binding adenosine-5'-diphosphate: F179 (≠ V402), R180 (≠ N403), R181 (≠ H404), I269 (≠ M478), T271 (= T480), K273 (≠ E482), D274 (= D483)
binding adenosine-5'-triphosphate: R180 (≠ N403), R180 (≠ N403), R181 (≠ H404), I193 (= I416), T195 (= T418), T197 (≠ W420), D198 (= D421), V233 (= V442), I234 (= I443), G255 (≠ S464)

Sites not aligning to the query:

binding adenosine-5'-diphosphate: 155, 158, 159
binding adenosine monophosphate: 68, 69, 72, 73, 88
binding adenosine-5'-triphosphate: 37, 51, 53, 55, 56, 91, 94, 95, 115, 116, 134

5g5xA Cbs domain tandem of site-2 protease from archaeoglobus fulgidus in complex with llama nanobody - nucleotide-bound form (see paper)
34% identity, 22% coverage: 379:487/490 of query aligns to 6:110/119 of 5g5xA

query
sites
5g5xA

T

T

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A
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binding adenosine monophosphate: V8 (≠ A381), V9 (≠ I382), H29 (≠ V402), F32 (≠ L405), R89 (≠ A465), I101 (≠ M478), S103 (≠ T480), D106 (= D483)
binding adenosine-5'-triphosphate: I43 (= I416), T45 (= T418), H47 (≠ W420), D48 (= D421), S63 (≠ T439), V66 (= V442), V67 (≠ I443), I87 (= I463), G88 (≠ S464), R89 (≠ A465)

2yzqA Crystal structure of uncharacterized conserved protein from pyrococcus horikoshii
44% identity, 17% coverage: 405:489/490 of query aligns to 138:224/224 of 2yzqA

query
sites
2yzqA

L

L

P

P

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V

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K

S

D

E

G

G

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N

L

L

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I

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x
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x
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binding s-adenosylmethionine: I150 (= I416), D152 (≠ T418), T154 (≠ W420), D155 (= D421), T174 (= T439), V177 (= V442), I178 (= I443), S197 (≠ N462), I198 (= I463), E199 (≠ S464), Q200 (≠ A465)

P9WKI7 Inosine-5'-monophosphate dehydrogenase; IMP dehydrogenase; IMPD; IMPDH; IMPDH2; EC 1.1.1.205 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
33% identity, 22% coverage: 377:486/490 of query aligns to 129:238/529 of P9WKI7

query
sites
P9WKI7

V

M

M

V

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N

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Sites not aligning to the query:

283 binding
289 binding
336 binding in other chain
338 binding in other chain
339 binding
341 binding in other chain
343 binding
374:376 binding
397:398 binding
421:425 binding
458 binding ; binding
511 binding
512 binding
513 binding

4gqyA Crystal structure of cbsx2 in complex with amp (see paper)
31% identity, 22% coverage: 374:480/490 of query aligns to 4:134/147 of 4gqyA

query
sites
4gqyA

V

V

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G

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F

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M

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N

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L

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D

D

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L

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x
V

V

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T
x
S

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W

Y

D
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D

I

L

-

L

-

A

-

L

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D

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I

-

S

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G

K

D

A

V

V

D

A

S

T

T

K

W

K

K

T

T

G

F

N

N

-

E

-

L

-

Q

-

K

-

L

-

I

-

S

-

K

-

T

-

Y

-

G

-

K

-

V

V

V

A

G

E

D

I

L

M

M

T
|
T

R

P

K

S

V
x
P

I
x
L

T

V

A

V

L

R

P

D

D

S

E

T

P

N

V

L

E

E

I

D

A

A

R

R

K

L

M

L

E

L

K

E

H

T

N

K

I
x
F

S
x
R

A
x
R

L

L

P

P

V

V

D

D

A

A

K

D

Q

G

R

K

V

L

I

I

G

G

M

I

V

L

T

T

binding adenosine monophosphate: V50 (≠ I416), S52 (≠ T418), D55 (= D421), T93 (= T439), P96 (≠ V442), L97 (≠ I443), F117 (≠ I463), R118 (≠ S464), R119 (≠ A465)

7pjiA Crystal structure of pseudomonas aeruginosa guab (imp dehydrogenase) bound to atp and gdp at 1.65a resolution (see paper)
31% identity, 26% coverage: 359:486/490 of query aligns to 79:202/445 of 7pjiA

query
sites
7pjiA

R

Q

E

A

C

A

N

E

F

V

K

R

P

K

M

V

R

K

Q
x
K

R

H

E

E

V

T

K

A

F

I

V
|
V

R

R

S

D

V

-

M

-

T

-

P

-

A
x
P

I
x
V

T

T

I

V

E

T

P

P

E

S

T

T

S

K

V

I

D

I

E

E

A

L

S

L

R

Q

I

M

M

A

I

R

Q

E

K

Y

G

G

V
x
F

N
x
S

H
x
G

L

F

P

P

V

V

K

E

D

Q

G

G

R

E

L

L

V

V

G

G

I

I

V

V

T
|
T

S

G

W
x
R

D
|
D

I

L

A

-

K

-

A

R

V

V

A

K

T

P

K

N

K

A

T

G

G

D

N

T

V

V

A

A

E

A

I

I

M

M

T
|
T

-

P

-

K

R

D

K

K

V
x
L

I
x
V

T

T

A

A

L

R

P

E

D

G

E

T

P

P

V

L

E

E

I

E

A

M

A

K

R

A

K

K

M

L

E

Y

K

E

H

N

N

R

I
|
I

S

E

A
x
K

L

M

P

L

V

V

D

D

A

E

K

N

Q

F

R

Y

V

L

I

R

G

G

M

L

V

V

T
|
T

S

F

E
x
R

D
|
D

L

I

S

E

K

K

binding adenosine-5'-triphosphate: T134 (= T418), R136 (≠ W420), D137 (= D421), T153 (= T439), L158 (≠ V442), V159 (≠ I443), I179 (= I463), K181 (≠ A465)
binding guanosine-5'-diphosphate: K88 (≠ Q368), V94 (= V374), P97 (≠ A381), V98 (≠ I382), F118 (≠ V402), S119 (≠ N403), G120 (≠ H404), T196 (= T480), R198 (≠ E482), D199 (= D483)

Sites not aligning to the query:

binding inosinic acid: 49, 302, 303, 304, 337, 361, 377, 379, 380, 382, 383

7qemB Bacterial impdh chimera (see paper)
32% identity, 24% coverage: 368:486/490 of query aligns to 86:204/428 of 7qemB

query
sites
7qemB

Q

R

R

R

E

V

V

K

K

K

F

H

V

E

R

S

S

A

V

I

M

V

T

R

P

D

A

P

I

V

T

T

I

V

E

T

P

P

E

S

T

T

S

K

V

I

D

I

E

E

A

L

S

L

R

Q

I

M

M

A

I

R

Q

E

K

Y

G

G

V

F

N

S

H

G

L

F

P

P

V

V

K

E

D

Q

G

G

R

E

L

L

V

V

G

G

I

I

V

V

T

T

S

G

W

R

D

D

I

L

A

-

K

-

A

R

V

V

A

K

T

P

K

N

K

A

T

G

G

D

N

T

V

V

A

A

E

A

I

I

M

M

T

T

-

P

-

K

R

D

K

K

V

L

I

V

T

T

A

A

L

R

P

E

D

G

E

T

P

P

V

L

E

E

I

E

A

M

A

K

R

A

K

K

M

L

E

Y

K

E

H

N

N

R

I

I

S

E

A

K

L

M

P

L

V

V

D

D

A

E

K

N

Q

F

R

Y

V

L

I

R

G

G

M

L

V

V

T

T

S

F

E

R

D

D

L

I

S

E

K

K

Sites not aligning to the query:

binding inosinic acid: 304, 306, 339, 340, 341, 362, 363

P0C0H6 Inosine-5'-monophosphate dehydrogenase; IMP dehydrogenase; IMPD; IMPDH; EC 1.1.1.205 from Streptococcus pyogenes (see paper)
30% identity, 21% coverage: 384:488/490 of query aligns to 104:210/493 of P0C0H6

query
sites
P0C0H6

I

L

E

T

P

P

E

E

T

H

S

K

V

V

D

S

E

E

A

A

S

E

R

E

I

L

M

M

I

Q

Q

R

K

Y

G

R

V

I

N

S

H

G

L

V

P

P

V

I

V

V

K

E

-

T

-

L

-

A

D

N

G

R

R

K

L

L

V

V

G

G

I

I

V

I

T

T

S

N

W

R

D

D

I

M

A

R

K

-

A

-

V

F

A

I

T

S

K

D

K

Y

T

N

G

A

N

P

V

I

A

S

E

E

I

H

M

M

T

T

R

S

K

E

-

H

V

L

I

V

T

T

A

A

L

A

P

V

D

G

E

T

P

D

V

L

E

E

I

T

A

A

A

E

R

R

K

I

M

L

E

H

K

E

H

H

N

R

I

I

S

E

A

K

L

L

P

P

V

L

V

V

D

D

A

N

K

S

Q

G

R

R

V

L

I

S

G

G

M

L

V

I

T

T

S

I

E

K

D

D

L

I

S

E

K

K

L

V

L

I

Sites not aligning to the query:

1 modified: Initiator methionine, Removed
308 binding
406 R→A: No activity.
421 E→Q: No activity.
450 Y→A: No effect.; Y→D: Reduces activity by 75%.

1zfjA Inosine monophosphate dehydrogenase (impdh; ec 1.1.1.205) from streptococcus pyogenes (see paper)
30% identity, 21% coverage: 384:488/490 of query aligns to 103:209/476 of 1zfjA

query
sites
1zfjA

I

L

E

T

P

P

E

E

T

H

S

K

V

V

D

S

E

E

A

A

S

E

R

E

I

L

M

M

I

Q

Q

R

K

Y

G

R

V

I

N

S

H

G

L

V

P

P

V

I

V

V

K

E

-

T

-

L

-

A

D

N

G

R

R

K

L

L

V

V

G

G

I

I

V

I

T

T

S

N

W

R

D

D

I

M

A

R

K

-

A

-

V

F

A

I

T

S

K

D

K

Y

T

N

G

A

N

P

V

I

A

S

E

E

I

H

M

M

T

T

R

S

K

E

-

H

V

L

I

V

T

T

A

A

L

A

P

V

D

G

E

T

P

D

V

L

E

E

I

T

A

A

A

E

R

R

K

I

M

L

E

H

K

E

H

H

N

R

I

I

S

E

A

K

L

L

P

P

V

L

V

V

D

D

A

N

K

S

Q

G

R

R

V

L

I

S

G

G

M

L

V

I

T

T

S

I

E

K

D

D

L

I

S

E

K

K

L

V

L

I

Sites not aligning to the query:

binding inosinic acid: 52, 306, 307, 308, 309, 342, 365, 366, 389, 391, 392, 393, 471, 476

6gk9A Inhibited structure of impdh from pseudomonas aeruginosa (see paper)
30% identity, 26% coverage: 361:486/490 of query aligns to 82:197/424 of 6gk9A

query
sites
6gk9A

C

A

N

E

F

V

K

R

P

K

M

V

R

K

Q

K

R

H

E

E

V

T

K

A

F

I

V

V

R

R

S

D

V

-

M

-

T

-

P

-

A

P

I

V

T

T

I

V

E

T

P

P

E

S

T

T

S

K

V

I

D

I

E

E

A

L

S

L

R

Q

I

M

M

A

I

R

Q

E

K

Y

G

G

V

F

N

S

H
x
G

L

F

P

P

V

V

K

E

D

Q

G

G

R

E

L

L

V

V

G

G

I
|
I

V

V

T

T

S

G

W

R

D

D

I

L

A

R

K

D

A

-

V

-

A

-

T

-

K

-

T

-

G

-

N

T

V

V

A

A

E

A

I

I

M

M

T

T

-

P

-

K

R

D

K

K

V

L

I
x
V

T

T

A

A

L

R

P

E

D

G

E

T

P

P

V

L

E

E

I

E

A

M

A

K

R

A

K

K

M

L

E

Y

K

E

H

N

N

R

I
|
I

S

E

A
x
K

L

M

P

L

V

V

D

D

A

E

K

N

Q

F

R

Y

V

L

I

R

G

G

M

L

V

V

T

T

S

F

E

R

D

D

L

I

S

E

K

K

binding (5~{S})-7-azanyl-5-(4-chlorophenyl)-2,4-bis(oxidanylidene)-1,5-dihydropyrano[2,3-d]pyrimidine-6-carbonitrile: G121 (≠ H404), I133 (= I416), V154 (≠ I443), I174 (= I463), K176 (≠ A465)

7qdxA Bacterial impdh chimera (see paper)
33% identity, 24% coverage: 368:486/490 of query aligns to 81:198/402 of 7qdxA

query
sites
7qdxA

Q

R

R

R

E

V

V

K

K

K

F

H

V

E

R

S

S

A

V

I

M

V

T

R

P

D

A

P

I
x
V

T

T

I

V

E

T

P

P

E

S

T

T

S

K

V

I

D

I

E

E

A

L

S

L

R

Q

I

M

M

A

I

R

Q

E

K

Y

G

G

V
x
F

N

S

H

G

L

F

P

P

V

V

K

E

D

Q

G

G

R

E

L

L

V

V

G

G

I
|
I

V

V

T
|
T

S

G

W
x
R

D
|
D

I

L

A

-

K

-

A

-

V

-

A

R

T

V

K

K

K

P

T

N

G

G

N

D

-

T

V

V

A

A

E

A

I

I

M

M

T
|
T

-

P

-

K

R

D

K

K

V
x
L

I
x
V

T

T

A

A

L

R

P

E

D

G

E

T

P

P

V

L

E

E

I

E

A

M

A

K

R

A

K

K

M

L

E

Y

K

E

H

N

N

R

I
|
I

S
x
E

A
x
K

L

M

P

L

V

V

D

D

A

E

K

N

Q

F

R

Y

V

L

I

R

G

G

M
x
L

V

V

T
|
T

S

F

E
x
R

D
|
D

L

I

S

E

K

K

binding adenosine-5'-triphosphate: V95 (≠ I382), F115 (≠ V402), I129 (= I416), T131 (= T418), R133 (≠ W420), D134 (= D421), T149 (= T439), L154 (≠ V442), V155 (≠ I443), I175 (= I463), E176 (≠ S464), E176 (≠ S464), K177 (≠ A465), K177 (≠ A465), L190 (≠ M478), T192 (= T480), R194 (≠ E482), D195 (= D483)

4fryB The structure of a putative signal-transduction protein with cbs domains from burkholderia ambifaria mc40-6 (see paper)
32% identity, 22% coverage: 383:489/490 of query aligns to 20:129/138 of 4fryB

query
sites
4fryB

T

T

I

V

E

T

P

K

E

N

T

D

S

F

V

V

D

Y

E

D

A

A

S

I

R

K

I

L

M

M

I

A

Q

E

K

K

G

G

V
x
I

N
x
G

H
x
A

L

L

P

L

V

V

K

D

D

G

G

D

R

D

L

I

V

A

G

G

I
|
I

V

V

T
|
T

S

E

W
x
R

D
|
D

I

Y

A

A

K

R

A

K

V

V

A

V

-

L

-

Q

-

E

-

R

T

S

K

S

K

K

T

A

G

T

N

R

V

V

A

E

E

E

I

I

M

M

T
|
T

R

A

K

K

V
|
V

I
x
R

T

Y

A

V

L

E

P

P

D

S

E

Q

P

S

V

T

E

D

I

E

A

C

A

M

R

A

K

L

M
|
M

E
x
T

K

E

H

H

N
x
R

I
x
M

S
x
R

A
x
H

L

L

P

P

V

V

V

L

D

D

A

G

K

G

Q

-

R

K

V

L

I

I

G

G

M
x
L

V

I

T
x
S

S

I

E
x
G

D
|
D

L

L

S

V

K
|
K

L

S

L

V

V

I

binding adenosine monophosphate: I53 (= I416), T55 (= T418), D58 (= D421), T80 (= T439), V83 (= V442), R84 (≠ I443), M104 (≠ I463), R105 (≠ S464), H106 (≠ A465)
binding nicotinamide-adenine-dinucleotide: I39 (≠ V402), G40 (≠ N403), A41 (≠ H404), R57 (≠ W420), M99 (= M458), T100 (≠ E459), R103 (≠ N462), M104 (≠ I463), R105 (≠ S464), H106 (≠ A465), L118 (≠ M478), S120 (≠ T480), G122 (≠ E482), D123 (= D483), K126 (= K486)

Sites not aligning to the query:

binding nicotinamide-adenine-dinucleotide: 11, 18, 19

4z87A Structure of the imp dehydrogenase from ashbya gossypii bound to gdp (see paper)
30% identity, 25% coverage: 366:486/490 of query aligns to 107:229/498 of 4z87A

query
sites
4z87A

M

M

R

V

Q

R

R

R

E

V

V

K

K
|
K

F

Y

V
x
E

R
x
N

S
x
G

V

F

M

I

T

N

P

A

A
x
P

I
x
V

T

V

I

V

E

G

P

P

E

D

T

A

S

T

V

V

D

A

E

D

A

V

S

R

R

R

I

M

M

K

I

N

Q

E

K

F

G

G

V
x
F

N
x
A

H
x
G

L

F

P

P

V

V

V

T

K

D

D

D

G

G

R

K

-

P

-

T

-

G

-

K

L

L

V

Q

G

G

I

I

V

I

T
|
T

S

S

W

R

D
|
D

I

I

A

Q

K

-

A

-

V

F

A

V

T

E

K

D

K

E

T

T

G

L

N

L

V

V

A

S

E

E

I

I

M

M

T
|
T

R

K

K
x
D

V
|
V

I
|
I

T

T

A

G

L

K

P

Q

D

G

E

I

P

N

V

L

E
|
E

I

E

A

A

A
x
N

R

Q

K

I

M

L

E

K

K

N

H

T

N

K

I
x
K

S
x
G

A
x
K

L

L

P

P

V

I

V

V

D

D

A

E

K

A

Q

G

R

C

V

L

I

V

G

S

M

M

V

L

T

S

S

R

E
x
T

D
|
D

L

L

S

M

K

K

binding guanosine-5'-diphosphate: K113 (= K372), E115 (≠ V374), N116 (≠ R375), N116 (≠ R375), G117 (≠ S376), P122 (≠ A381), V123 (≠ I382), F143 (≠ V402), A144 (≠ N403), G145 (≠ H404), T163 (= T418), D166 (= D421), T182 (= T439), D184 (≠ K441), V185 (= V442), I186 (= I443), E195 (= E452), N198 (≠ A455), K206 (≠ I463), G207 (≠ S464), K208 (≠ A465), T225 (≠ E482), D226 (= D483)

Sites not aligning to the query:

binding guanosine-5'-monophosphate: 72, 74, 323, 329, 330, 331, 332, 334, 365, 388, 389, 412, 414, 415, 416
binding guanosine-5'-diphosphate: 230, 238, 243

7oj1B Bacillus subtilis impdh in complex with ap4a (see paper)
27% identity, 23% coverage: 375:488/490 of query aligns to 94:208/425 of 7oj1B

query
sites
7oj1B

R

R

S

G

V
x
I

M

T

T

N

P

P

A

-

I
x
F

T

F

I

L

E

T

P

P

E

D

T

H

S

Q

V

V

D

F

E

D

A

A

S

E

R

H

I

L

M

M

I

G

Q

K

K

Y

G

R

V
x
I

N
x
S

H

G

L

V

P

P

V

I

V

V

-

N

-

E

K

E

D

D

G

Q

R

K

L

L

V

V

G

G

I
|
I

V

I

T
|
T

S

N

W

R

D

D

I

L

A

-

K

R

A

F

V

I

A

A

T

D

K

Y

K

S

T

M

G

-

N

K

V

I

A

S

E

D

I

V

M

M

T

T

R

K

K

E

-

E

V

L

I
x
V

T

T

A

A

L

S

P

V

D

G

E

T

P

T

V

L

E

D

I

E

A

A

A

E

R

K

K

I

M

L

E

Q

K

K

H

H

N

K

I
|
I

S
x
E

A
x
K

L

L

P

P

V

L

V

V

D

D

A

D

K

Q

Q

N

R

K

V

L

I

K

G

G

M
x
L

V

I

T
|
T

S

I

E
x
K

D
|
D

L

I

S

E

K

K

L

V

L

I

binding bis(adenosine)-5'-tetraphosphate: I96 (≠ V377), F100 (≠ I382), I120 (≠ V402), S121 (≠ N403), I137 (= I416), T139 (= T418), V163 (≠ I443), I183 (= I463), E184 (≠ S464), K185 (≠ A465), L198 (≠ M478), T200 (= T480), K202 (≠ E482), D203 (= D483)

5tc3A Structure of imp dehydrogenase from ashbya gossypii bound to atp and gdp (see paper)
30% identity, 25% coverage: 366:486/490 of query aligns to 107:229/488 of 5tc3A

query
sites
5tc3A

M

M

R

V

Q

R

R

R

E

V

V

K

K
|
K

F

Y

V
x
E

R
x
N

S
x
G

V

F

M
x
I

T

N

P

A

A
x
P

I
x
V

T

V

I

V

E

G

P

P

E

D

T

A

S

T

V

V

D

A

E

D

A

V

S

R

R

R

I

M

M

K

I

N

Q

E

K

F

G

G

V
x
F

N
x
A

H
x
G

L

F

P

P

V

V

V

T

K

D

D

D

G

G

R

K

-

P

-

T

-

G

-

K

L

L

V

Q

G

G

I

I

V

I

T
|
T

S

S

W
x
R

D
|
D

I

I

A

Q

K

-

A

-

V

F

A

V

T

E

K

D

K

E

T

T

G

L

N

L

V

V

A

S

E

E

I

I

M

M

T
|
T

R

K

K

D

V
|
V

I
|
I

T

T

A

G

L

K

P

Q

D

G

E

I

P

N

V

L

E

E

I

E

A

A

A
x
N

R

Q

K

I

M

L

E

K

K

N

H

T

N

K

I

K

S
x
G

A
x
K

L

L

P

P

V

I

V

V

D

D

A

E

K

A

Q

G

R

C

V

L

I

V

G

S

M
|
M

V

L

T
x
S

S

R

E
x
T

D
|
D

L
|
L

S

M

K
|
K

binding adenosine-5'-triphosphate: T163 (= T418), R165 (≠ W420), D166 (= D421), T182 (= T439), V185 (= V442), I186 (= I443), G207 (≠ S464), K208 (≠ A465)
binding guanosine-5'-diphosphate: K113 (= K372), E115 (≠ V374), N116 (≠ R375), N116 (≠ R375), G117 (≠ S376), I119 (≠ M378), P122 (≠ A381), V123 (≠ I382), F143 (≠ V402), A144 (≠ N403), G145 (≠ H404), N198 (≠ A455), K208 (≠ A465), M221 (= M478), S223 (≠ T480), T225 (≠ E482), D226 (= D483), D226 (= D483), L227 (= L484), K229 (= K486)

Sites not aligning to the query:

binding guanosine-5'-monophosphate: 72, 323, 329, 330, 332, 334, 365, 410, 416
binding guanosine-5'-diphosphate: 230, 238, 243

5mcpC Structure of imp dehydrogenase from ashbya gossypii bound to atp (see paper)
30% identity, 25% coverage: 366:486/490 of query aligns to 110:232/446 of 5mcpC

query
sites
5mcpC

M

M

R

V

Q

R

R

R

E

V

V

K

K

K

F

Y

V

E

R

N

S

G

V

F

M
x
I

T

N

P

A

A

P

I
x
V

T

V

I

V

E

G

P

P

E

D

T

A

S

T

V

V

D

A

E

D

A

V

S

R

R

R

I

M

M

K

I

N

Q

E

K

F

G

G

V
x
F

N

A

H
x
G

L

F

P

P

V

V

V

T

K

D

D

D

G

G

R

K

-

P

-

T

-

G

-

K

L

L

V

Q

G

G

I
|
I

V

I

T
|
T

S
|
S

W
x
R

D
|
D

I

I

A

Q

K

-

A

-

V

F

A

V

T

E

K

D

K

E

T

T

G

L

N

L

V

V

A

S

E

E

I

I

M

M

T

T

R

K

K

D

V

V

I
|
I

T

T

A

G

L

K

P

Q

D

G

E

I

P

N

V

L

E

E

I

E

A

A

A

N

R

Q

K

I

M

L

E

K

K

N

H

T

N

K

I

K

S
x
G

A
x
K

L

L

P

P

V

I

V

V

D

D

A

E

K

A

Q

G

R

C

V

L

I

V

G

S

M
|
M

V

L

T
x
S

S

R

E
x
T

D
|
D

L

L

S

M

K

K

binding adenosine-5'-triphosphate: I122 (≠ M378), V126 (≠ I382), F146 (≠ V402), G148 (≠ H404), I164 (= I416), T166 (= T418), S167 (= S419), S167 (= S419), R168 (≠ W420), D169 (= D421), I189 (= I443), G210 (≠ S464), K211 (≠ A465), K211 (≠ A465), M224 (= M478), S226 (≠ T480), T228 (≠ E482), D229 (= D483)

Sites not aligning to the query:

binding adenosine-5'-triphosphate: 256, 279, 280, 286

5x9gA Crystal structure of the cytosolic domain of the mg2+ channel mgte in complex with atp (see paper)
40% identity, 16% coverage: 411:488/490 of query aligns to 174:248/248 of 5x9gA

query
sites
5x9gA

G

G

R

R

L

L

V

K

G

G

I
x
V

V

L

T
x
S

S

L

W
x
R

D
|
D

I

L

A

I

K

-

A

-

V

V

A

A

T

D

K

P

K

R

T

T

G

-

N

R

V

V

A

A

E

E

I

I

M

M

T

N

R

P

K

K

V

V

I
x
V

T

Y

A

V

L

R

P

T

D

D

E

T

P

D

V

Q

E

E

I

E

A

V

A

A

R

R

K

L

M

M

E

A

K

D

H

Y

N

D

I
x
F

S

T

A

V

L

L

P

P

V

V

D

D

A

E

K

E

Q

G

R

R

V

L

I

V

G

G

M

I

V

V

T

T

S

V

E

D

D
|
D

L

V

S

L

K

D

L

V

L

L

binding adenosine-5'-triphosphate: V179 (≠ I416), S181 (≠ T418), R183 (≠ W420), D184 (= D421), V203 (≠ I443), F223 (≠ I463)
binding magnesium ion: D243 (= D483)

Sites not aligning to the query:

Query Sequence

>WP_013683759.1 NCBI__GCF_000194625.1:WP_013683759.1
MKTVEEINERIREGNVCVVTASEMKELVAELGAEKAAKEVDVVTTGTFGAMCSSGVFMNF
GHSDPPIKMQKIWLNDVEAYTGIAAVDAYLGVTQVSEKHEEYGGAHVIEELVRGREVVLR
AISKGTDCYPRKEIITEIALEDLNQAEMLNPRNAYQRYKAATNSSQQLLRTYMGTLLPNF
GNVTFAGCGEISPLNNDPEYRTIGVGTRIFLCGAKGYVIGEGTQHCPPFGTLMVKGNLKE
MKPEFMRAAVFPGYGVTMYVGIGIPIPILDADMARATAIRDEEIWTEIIDFGVPRRQRPV
VKKVNYAELKSGKVEINGEEVRVSPLSSFYMAEKIMEELKRQIERAEFFLSPPAERISRE
CNFKPMRQREVKFVRSVMTPAITIEPETSVDEASRIMIQKGVNHLPVVKDGRLVGIVTSW
DIAKAVATKKTGNVAEIMTRKVITALPDEPVEIAARKMEKHNISALPVVDAKQRVIGMVT
SEDLSKLLVR

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory