SitesBLAST
Comparing WP_013684424.1 NCBI__GCF_000194625.1:WP_013684424.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
6yu6B Crystal structure of mhst in complex with l-leucine (see paper)
37% identity, 99% coverage: 3:432/434 of query aligns to 2:444/446 of 6yu6B
6yu7A Crystal structure of mhst in complex with l-tyrosine (see paper)
37% identity, 99% coverage: 3:430/434 of query aligns to 2:442/442 of 6yu7A
6yu4A Crystal structure of mhst in complex with l-4f-phenylalanine (see paper)
37% identity, 99% coverage: 3:430/434 of query aligns to 2:442/442 of 6yu4A
- binding 4-fluoro-l-phenylalanine: S18 (= S19), A19 (= A20), G21 (= G22), L22 (= L23), G23 (= G24), Y101 (= Y100), F223 (= F212), T224 (≠ S213), S226 (= S215), M229 (≠ S218), L321 (≠ M310)
6yu5A Crystal structure of mhst in complex with l-valine (see paper)
37% identity, 98% coverage: 3:427/434 of query aligns to 2:439/441 of 6yu5A
6yu3A Crystal structure of mhst in complex with l-phenylalanine (see paper)
37% identity, 98% coverage: 3:427/434 of query aligns to 2:439/441 of 6yu3A
6yu2A Crystal structure of mhst in complex with l-isoleucine (see paper)
37% identity, 98% coverage: 3:427/434 of query aligns to 2:439/441 of 6yu2A
4us3A Crystal structure of the bacterial nss member mhst in an occluded inward-facing state (see paper)
37% identity, 98% coverage: 3:427/434 of query aligns to 2:439/441 of 4us3A
- binding sodium ion: G17 (= G18), A19 (= A20), V20 (= V21), V20 (= V21), G21 (= G22), N24 (= N25), T224 (≠ S213), D256 (= D245), A313 (= A302), S316 (≠ T305), S317 (= S306)
- binding tryptophan: S18 (= S19), A19 (= A20), L22 (= L23), G23 (= G24), Y101 (= Y100), F223 (= F212), T224 (≠ S213), S226 (= S215), M229 (≠ S218), S320 (= S309), L321 (≠ M310)
4us4A Crystal structure of the bacterial nss member mhst in an occluded inward-facing state (lipidic cubic phase form) (see paper)
36% identity, 97% coverage: 11:430/434 of query aligns to 1:433/433 of 4us4A
- binding (2s)-2,3-dihydroxypropyl(7z)-pentadec-7-enoate: A173 (≠ V171), T180 (≠ S178), I287 (≠ V285), R288 (≠ P286), L289 (≠ Y287)
- binding sodium ion: G8 (= G18), S9 (= S19), A10 (= A20), V11 (= V21), V11 (= V21), N15 (= N25), T215 (≠ S213), D247 (= D245), A304 (= A302), S307 (≠ T305), S308 (= S306)
- binding tryptophan: S9 (= S19), A10 (= A20), G12 (= G22), G14 (= G24), Y92 (= Y100), F214 (= F212), T215 (≠ S213), S217 (= S215), M220 (≠ S218), L312 (≠ M310)
3gwwA Leucine transporter leut in complex with s-fluoxetine (see paper)
32% identity, 99% coverage: 3:433/434 of query aligns to 1:463/501 of 3gwwA
- binding leucine: A18 (= A20), G20 (= G22), G22 (= G24), Y104 (= Y100), F244 (= F212), T245 (≠ S213), S247 (= S215), F250 (≠ S218), I350 (≠ M310)
- binding (3S)-N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine: L21 (= L23), G22 (= G24), R26 (= R28), Y104 (= Y100), A310 (≠ G270), F311 (≠ P271), D392 (= D362), D395 (= D365)
3uslA Crystal structure of leut bound to l-selenomethionine in space group c2 from lipid bicelles (see paper)
32% identity, 99% coverage: 3:433/434 of query aligns to 1:465/502 of 3uslA
- binding selenomethionine: A18 (= A20), G20 (= G22), G22 (= G24), Y104 (= Y100), F246 (= F212), T247 (≠ S213), S249 (= S215), S348 (= S306), I352 (≠ M310)
- binding sodium ion: G16 (= G18), N17 (≠ S19), A18 (= A20), V19 (= V21), V19 (= V21), G20 (= G22), N23 (= N25), T247 (≠ S213), N279 (≠ D245), A344 (= A302), T347 (= T305), S348 (= S306)
- binding phosphocholine: N83 (≠ K80), R84 (≠ K81), F85 (= F82)
3usgA Crystal structure of leut bound to l-leucine in space group c2 from lipid bicelles (see paper)
32% identity, 99% coverage: 3:433/434 of query aligns to 1:465/502 of 3usgA
- binding leucine: A18 (= A20), G20 (= G22), G22 (= G24), F246 (= F212), T247 (≠ S213), S249 (= S215), F252 (≠ S218)
- binding sodium ion: G16 (= G18), N17 (≠ S19), A18 (= A20), V19 (= V21), V19 (= V21), G20 (= G22), N23 (= N25), T247 (≠ S213), N279 (≠ D245), A344 (= A302), T347 (= T305), S348 (= S306)
- binding phosphocholine: N83 (≠ K80), R84 (≠ K81)
3f3aA Crystal structure of leut bound to l-tryptophan and sodium (see paper)
32% identity, 99% coverage: 3:433/434 of query aligns to 1:465/504 of 3f3aA
- binding sodium ion: G16 (= G18), N17 (≠ S19), A18 (= A20), V19 (= V21), V19 (= V21), G20 (= G22), N23 (= N25), T247 (≠ S213), N279 (≠ D245), A344 (= A302), T347 (= T305), S348 (= S306)
- binding tryptophan: R7 (= R9), A18 (= A20), G20 (= G22), L21 (= L23), G22 (= G24), R26 (= R28), Y104 (= Y100), G242 (= G208), F246 (= F212), F246 (= F212), T247 (≠ S213), S249 (= S215), F252 (≠ S218), D265 (≠ K231), Q266 (≠ I232), D267 (≠ S233), F299 (= F257), N303 (≠ S261), A306 (≠ G264), I307 (≠ F265), A310 (= A268), N314 (≠ K272), S348 (= S306), I352 (≠ M310), D397 (= D365), G401 (= G369), T402 (≠ S370), G432 (≠ N400)
3mpnA F177r1 mutant of leut (see paper)
32% identity, 99% coverage: 3:433/434 of query aligns to 1:466/505 of 3mpnA
- binding leucine: N17 (≠ S19), A18 (= A20), G20 (= G22), L21 (= L23), G22 (= G24), Y104 (= Y100), F247 (= F212), T248 (≠ S213), S250 (= S215), F253 (≠ S218), S349 (= S306)
- binding S-[(1-oxyl-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl] methanesulfonothioate: C171 (≠ I140), A377 (≠ S334)
2q6hA Crystal structure analysis of leut complexed with l-leucine, sodium, and clomipramine (see paper)
32% identity, 99% coverage: 3:433/434 of query aligns to 3:468/512 of 2q6hA
- binding 3-(3-chloro-5h-dibenzo[b,f]azepin-5-yl)-n,n-dimethylpropan-1-amine: R28 (= R28), Q32 (≠ I32), R189 (≠ K156), F190 (≠ T157), I193 (= I160), F316 (≠ P271), F346 (= F301), L396 (= L361), D397 (= D362)
- binding leucine: A20 (= A20), G22 (= G22), G24 (= G24), Y106 (= Y100), F249 (= F212), T250 (≠ S213), S252 (= S215), F255 (≠ S218)
- binding sodium ion: G18 (= G18), A20 (= A20), V21 (= V21), V21 (= V21), G22 (= G22), N25 (= N25), T250 (≠ S213), N282 (≠ D245), A347 (= A302), T350 (= T305), S351 (= S306)
3gwvA Leucine transporter leut in complex with r-fluoxetine (see paper)
32% identity, 99% coverage: 3:433/434 of query aligns to 1:466/498 of 3gwvA
- binding leucine: A18 (= A20), G20 (= G22), G22 (= G24), Y104 (= Y100), F247 (= F212), T248 (≠ S213), S250 (= S215), F253 (≠ S218)
- binding (3R)-N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine: L21 (= L23), R26 (= R28), A313 (≠ G270), F314 (≠ P271), L394 (= L361), D395 (= D362), D398 (= D365)
2qeiA Crystal structure analysis of leut complexed with l-alanine, sodium, and clomipramine (see paper)
32% identity, 99% coverage: 3:433/434 of query aligns to 2:467/511 of 2qeiA
- binding alanine: A19 (= A20), G21 (= G22), G23 (= G24), Y105 (= Y100), F248 (= F212), T249 (≠ S213), S251 (= S215)
- binding 3-(3-chloro-5h-dibenzo[b,f]azepin-5-yl)-n,n-dimethylpropan-1-amine: R27 (= R28), V30 (≠ Y31), Q31 (≠ I32), Y104 (= Y99), R180 (= R148), R188 (≠ K156), F189 (≠ T157), F315 (≠ P271), F345 (= F301), D396 (= D362), D399 (= D365)
- binding sodium ion: G17 (= G18), A19 (= A20), V20 (= V21), V20 (= V21), G21 (= G22), N24 (= N25), T249 (≠ S213), N281 (≠ D245), A346 (= A302), T349 (= T305), S350 (= S306)
2q72A Crystal structure analysis of leut complexed with l-leucine, sodium, and imipramine (see paper)
32% identity, 99% coverage: 3:433/434 of query aligns to 2:467/511 of 2q72A
- binding 3-(5h-dibenzo[b,f]azepin-5-yl)-n,n-dimethylpropan-1-amine: R27 (= R28), V30 (≠ Y31), Q31 (≠ I32), R188 (≠ K156), F189 (≠ T157), I192 (= I160), A314 (≠ G270), F315 (≠ P271), F345 (= F301), D396 (= D362)
- binding leucine: A19 (= A20), G21 (= G22), L22 (= L23), G23 (= G24), Y105 (= Y100), F248 (= F212), T249 (≠ S213), S251 (= S215), F254 (≠ S218)
- binding sodium ion: G17 (= G18), A19 (= A20), V20 (= V21), V20 (= V21), G21 (= G22), N24 (= N25), T249 (≠ S213), N281 (≠ D245), A346 (= A302), T349 (= T305), S350 (= S306)
2qb4A Crystal structure analysis of leut complexed with l-leucine, sodium and desipramine (see paper)
32% identity, 99% coverage: 3:433/434 of query aligns to 1:466/510 of 2qb4A
- binding 3-(10,11-dihydro-5h-dibenzo[b,f]azepin-5-yl)-n-methylpropan-1-amine: R26 (= R28), V29 (≠ Y31), Q30 (≠ I32), I107 (= I103), R187 (≠ K156), F188 (≠ T157), I191 (= I160), A313 (≠ G270), F314 (≠ P271), F344 (= F301), D395 (= D362)
- binding leucine: A18 (= A20), G20 (= G22), L21 (= L23), G22 (= G24), Y104 (= Y100), F247 (= F212), T248 (≠ S213), S250 (= S215), F253 (≠ S218)
- binding sodium ion: G16 (= G18), A18 (= A20), V19 (= V21), V19 (= V21), G20 (= G22), N23 (= N25), T248 (≠ S213), N280 (≠ D245), A345 (= A302), T348 (= T305), S349 (= S306)
3gwuA Leucine transporter leut in complex with sertraline (see paper)
32% identity, 99% coverage: 3:433/434 of query aligns to 1:466/509 of 3gwuA
- binding leucine: A18 (= A20), G20 (= G22), G22 (= G24), Y104 (= Y100), F247 (= F212), T248 (≠ S213), S250 (= S215), F253 (≠ S218)
- binding (1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine: L25 (≠ W27), R26 (= R28), Y104 (= Y100), F247 (= F212), A313 (≠ G270), D395 (= D362), D398 (= D365)
3f4jA Crystal structure of leut bound to glycine and sodium (see paper)
32% identity, 99% coverage: 3:433/434 of query aligns to 1:466/509 of 3f4jA
- binding glycine: A18 (= A20), G20 (= G22), G22 (= G24), Y104 (= Y100), F247 (= F212), T248 (≠ S213), S250 (= S215)
- binding sodium ion: G16 (= G18), A18 (= A20), V19 (= V21), V19 (= V21), G20 (= G22), G22 (= G24), N23 (= N25), T248 (≠ S213), N280 (≠ D245), A345 (= A302), G346 (≠ A303), T348 (= T305), S349 (= S306)
Query Sequence
>WP_013684424.1 NCBI__GCF_000194625.1:WP_013684424.1
MVREKWSSRIGFLLAGIGSAVGLGNVWRFPYIVGQNGGGAFLIPYLISVFLFGLPLMLLE
FSTGRLFKGSVVSSLKKIRKKFKWIGIAVVSVLTVVLSYYLVITGWILAFFTFTLLGRET
SFESFAQTYFSPLFFVVVTIAASLIVMRGVRKGIEKTSKIMVPALGVLLAVMVIYSLSLP
NAMDGITFYLTPDLSKLSDSSIWAAAFGQAFFSLSVGSGILLTYGSYLEEKISLVNSSML
ITIFDLLVSFMSGLIVFSIASSFGFEVAAGPKLAFSTLPQVFDKVPYGFFLEGIFFLLLF
FAALTSAISMLEIGVAVLIDETSLDRFKSTSLLSSIILVLGFPAALSYSGISLQFTGRPV
LDLMDETFGSFGIPLTALLLSTSISWFLDNLVIAEEINKNAKWKIGKTVVFLTRYFIPIV
LLYVLLTRLHFYLV
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory