SitesBLAST
Comparing WP_013707094.1 NCBI__GCF_000195295.1:WP_013707094.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
2izzA Crystal structure of human pyrroline-5-carboxylate reductase
47% identity, 95% coverage: 10:268/273 of query aligns to 7:272/272 of 2izzA
- binding nicotinamide-adenine-dinucleotide: G8 (= G11), A9 (≠ V12), G10 (= G13), Q11 (≠ N14), L12 (≠ M15), S35 (vs. gap), P36 (vs. gap), N57 (= N58), A70 (= A70), V71 (= V71), K72 (= K72), I79 (≠ V79), C96 (≠ I96), A97 (= A97), A98 (= A98), M122 (= M118), T123 (≠ P119)
8td5A Structure of pycr1 complexed with nadh and tetrahydrothiophene-2- carboxylic acid
47% identity, 95% coverage: 10:268/273 of query aligns to 13:278/280 of 8td5A
- binding 1,4-dihydronicotinamide adenine dinucleotide: G14 (= G11), A15 (≠ V12), G16 (= G13), Q17 (≠ N14), L18 (≠ M15), S41 (vs. gap), P42 (vs. gap), L46 (≠ T41), N63 (= N58), A76 (= A70), V77 (= V71), I85 (≠ V79), C102 (≠ I96), A103 (= A97), A104 (= A98), M128 (= M118), T131 (= T121)
- binding (2R)-thiolane-2-carboxylic acid: S240 (= S230), A244 (≠ T234), T245 (= T235)
8td1A Structure of pycr1 complexed with 3-(6-oxa-9-azaspiro(4.5)decane-9- carbonyl)benzoic acid (see paper)
47% identity, 95% coverage: 10:268/273 of query aligns to 13:278/280 of 8td1A
8td0A Structure of pycr1 complexed with 5-oxo-7a-phenyl-hexahydropyrrolo[2, 1-b][1,3]thiazole-3-carboxylic acid (see paper)
47% identity, 95% coverage: 10:268/273 of query aligns to 13:278/280 of 8td0A
8tczA Structure of pycr1 complexed with 2-(pyridin-2-yl)cyclopropane-1- carboxylic acid (see paper)
47% identity, 95% coverage: 10:268/273 of query aligns to 13:278/280 of 8tczA
8tcxA Structure of pycr1 complexed with 2,4-dioxo-1,2,3,4- tetrahydroquinazoline-6-carboxylic acid (see paper)
47% identity, 95% coverage: 10:268/273 of query aligns to 13:278/280 of 8tcxA
5uatC Structure of human pycr-1 complexed with NADPH (see paper)
47% identity, 95% coverage: 10:268/273 of query aligns to 10:275/277 of 5uatC
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: A12 (≠ V12), G13 (= G13), Q14 (≠ N14), L15 (≠ M15), S38 (vs. gap), P39 (vs. gap), D40 (= D38), N60 (= N58), A73 (= A70), V74 (= V71), K75 (= K72), P76 (= P73), I82 (≠ V79), C99 (≠ I96), A100 (= A97), A101 (= A98), M125 (= M118), T128 (= T121)
8td6B Structure of pycr1 complexed with nadh and 2-(methylthio)acetic acid
47% identity, 95% coverage: 10:268/273 of query aligns to 12:277/281 of 8td6B
- binding [methylthio]acetate: G181 (= G172), S182 (= S173)
- binding 1,4-dihydronicotinamide adenine dinucleotide: G13 (= G11), A14 (≠ V12), G15 (= G13), Q16 (≠ N14), L17 (≠ M15), P41 (vs. gap), N62 (= N58), A75 (= A70), V76 (= V71), K77 (= K72), I80 (= I75), I84 (≠ V79), C101 (≠ I96), A102 (= A97), A103 (= A98), M127 (= M118), T128 (≠ P119)
8td3A Structure of pycr1 complexed with nadh and (s)-tetrahydro-2h-pyran-2- carboxylic acid
47% identity, 95% coverage: 10:268/273 of query aligns to 12:277/281 of 8td3A
- binding (2S)-oxane-2-carboxylic acid: A103 (= A98), G181 (= G172), V237 (= V228), S239 (= S230), T244 (= T235)
- binding 1,4-dihydronicotinamide adenine dinucleotide: G13 (= G11), A14 (≠ V12), G15 (= G13), Q16 (≠ N14), L17 (≠ M15), S40 (vs. gap), P41 (vs. gap), N62 (= N58), A75 (= A70), V76 (= V71), K77 (= K72), I80 (= I75), C101 (≠ I96), A102 (= A97), A103 (= A98), M127 (= M118), T128 (≠ P119), T130 (= T121)
8tcyA Structure of pycr1 complexed with 7-fluoro-2-oxo-1,2,3,4- tetrahydroquinoline-6-carboxylic acid (see paper)
47% identity, 95% coverage: 10:268/273 of query aligns to 13:278/281 of 8tcyA
5uavA Structure of human pycr-1 complexed with NADPH and l-tetrahydrofuroic acid (see paper)
47% identity, 96% coverage: 7:268/273 of query aligns to 7:275/278 of 5uavA
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: G11 (= G11), A12 (≠ V12), G13 (= G13), Q14 (≠ N14), L15 (≠ M15), S38 (vs. gap), P39 (vs. gap), D40 (= D38), N60 (= N58), A73 (= A70), V74 (= V71), K75 (= K72), I82 (≠ V79), C99 (≠ I96), A100 (= A97), A101 (= A98), M125 (= M118), T126 (≠ P119), T128 (= T121)
- binding tetrahydrofuran-2-carboxylic acid: G240 (= G233), A241 (≠ T234), T242 (= T235)
8tdcA Structure of pycr1 complexed with nadh and 1,3-dithiane-2-carboxylic acid
47% identity, 95% coverage: 10:268/273 of query aligns to 7:272/276 of 8tdcA
- binding 1,3-dithiane-2-carboxylic acid: V232 (= V228), S234 (= S230), G237 (= G233), A238 (≠ T234), T239 (= T235)
- binding 1,4-dihydronicotinamide adenine dinucleotide: G8 (= G11), A9 (≠ V12), G10 (= G13), Q11 (≠ N14), L12 (≠ M15), S35 (vs. gap), P36 (vs. gap), N57 (= N58), A70 (= A70), V71 (= V71), K72 (= K72), I79 (≠ V79), C96 (≠ I96), A97 (= A97), A98 (= A98), M122 (= M118), T123 (≠ P119), T125 (= T121)
8td8A Structure of pycr1 complexed with nadh and 2s-hydroxy-3,3- dimethylbutyric acid
47% identity, 95% coverage: 10:268/273 of query aligns to 7:272/276 of 8td8A
- binding (2S)-2-hydroxy-3,3-dimethylbutanoic acid: V232 (= V228), S234 (= S230), T239 (= T235)
- binding 1,4-dihydronicotinamide adenine dinucleotide: G8 (= G11), A9 (≠ V12), G10 (= G13), Q11 (≠ N14), L12 (≠ M15), P36 (vs. gap), N57 (= N58), A70 (= A70), V71 (= V71), K72 (= K72), C96 (≠ I96), A97 (= A97), A98 (= A98), M122 (= M118), T123 (≠ P119), T125 (= T121)
8td2A Structure of pycr1 complexed with nadh and cyclobutane-1,1- dicarboxylic acid
47% identity, 95% coverage: 10:268/273 of query aligns to 7:272/276 of 8td2A
- binding 1,4-dihydronicotinamide adenine dinucleotide: G8 (= G11), G10 (= G13), Q11 (≠ N14), L12 (≠ M15), P36 (vs. gap), L40 (≠ T41), N57 (= N58), A70 (= A70), V71 (= V71), P73 (= P73), I79 (≠ V79), C96 (≠ I96), A97 (= A97), A98 (= A98), M122 (= M118), T123 (≠ P119), T125 (= T121)
- binding cyclobutane-1,1-dicarboxylic acid: V232 (= V228), S234 (= S230), A238 (≠ T234), T239 (= T235)
8td7A Structure of pycr1 complexed with 2s-hydroxy-3-methylbutyric acid
47% identity, 95% coverage: 10:268/273 of query aligns to 13:278/282 of 8td7A
8tcwA Structure of pycr1 complexed with 2-methyl-3-(2-oxoimidazolidin-1-yl) benzoic acid (see paper)
47% identity, 95% coverage: 10:268/273 of query aligns to 13:278/282 of 8tcwA
6xp1A Structure of human pycr1 complexed with l-thiazolidine-2-carboxylate (see paper)
47% identity, 94% coverage: 12:268/273 of query aligns to 6:264/266 of 6xp1A
8tddA Structure of pycr1 complexed with nadh and 2-(furan-2-yl)acetic acid
47% identity, 95% coverage: 10:268/273 of query aligns to 9:274/278 of 8tddA
- binding 1,4-dihydronicotinamide adenine dinucleotide: G10 (= G11), A11 (≠ V12), G12 (= G13), Q13 (≠ N14), L14 (≠ M15), S37 (vs. gap), P38 (vs. gap), N59 (= N58), A72 (= A70), V73 (= V71), P75 (= P73), I81 (≠ V79), C98 (≠ I96), A99 (= A97), A100 (= A98), M124 (= M118), T125 (≠ P119), T127 (= T121)
- binding (furan-2-yl)acetic acid: M124 (= M118), T174 (= T168), G178 (= G172)
8td9A Structure of pycr1 complexed with nadh and l-pipecolic acid
47% identity, 96% coverage: 7:268/273 of query aligns to 7:275/279 of 8td9A
- binding 1,4-dihydronicotinamide adenine dinucleotide: G11 (= G11), A12 (≠ V12), G13 (= G13), Q14 (≠ N14), L15 (≠ M15), S38 (vs. gap), P39 (vs. gap), L43 (≠ T41), N60 (= N58), A73 (= A70), V74 (= V71), I82 (≠ V79), C99 (≠ I96), A100 (= A97), A101 (= A98), M125 (= M118), T128 (= T121)
- binding (2S)-piperidine-2-carboxylic acid: A101 (= A98), G179 (= G172), V235 (= V228), S237 (= S230), T242 (= T235)
8td4A Structure of pycr1 complexed with nadh and 1,3-dithiolane-2-carboxylic acid
47% identity, 95% coverage: 10:268/273 of query aligns to 9:274/279 of 8td4A
- binding 1,4-dihydronicotinamide adenine dinucleotide: G10 (= G11), A11 (≠ V12), G12 (= G13), Q13 (≠ N14), L14 (≠ M15), S37 (vs. gap), P38 (vs. gap), L42 (≠ T41), N59 (= N58), A72 (= A70), V73 (= V71), I81 (≠ V79), C98 (≠ I96), A99 (= A97), A100 (= A98), M124 (= M118), T125 (≠ P119), T127 (= T121)
- binding 1,3-dithiolane-2-carboxylic acid: V234 (= V228), S236 (= S230), A240 (≠ T234), T241 (= T235)
Query Sequence
>WP_013707094.1 NCBI__GCF_000195295.1:WP_013707094.1
MSIEKKLAVIGVGNMGSALTRAWLQAGLIEPASICLADADTERLRALAAELGVQTADNRQ
AVAADIVILAVKPQIIPEVLTDIRNRIGASHLIISIAAGLPLSYLEEMLPRARLLRVMPN
TPLLIRAGVAAIAQGTRATAQDLDLARKLFDSVGRSVIVEEKFMDAVTGLSGSGPAYVFL
FLEALADGGVKMGLPRQTALLLAAQTILGSAALFLESGHHPGILKDQVASPGGTTITGLH
VLEAGGFRGLIMSAVEAATSRSQELATVRPTRP
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory