SitesBLAST
Comparing WP_013707330.1 NCBI__GCF_000195295.1:WP_013707330.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
1ef9A The crystal structure of methylmalonyl coa decarboxylase complexed with 2s-carboxypropyl coa (see paper)
51% identity, 97% coverage: 10:259/259 of query aligns to 12:261/261 of 1ef9A
- active site: H66 (= H64), L71 (= L69), D82 (≠ Y80), R86 (≠ E84), G110 (= G108), E113 (= E111), P133 (= P131), V138 (≠ I136), Y140 (= Y138), N141 (= N139), E228 (= E226), Y238 (≠ W236)
- binding 2-carboxypropyl-coenzyme a: A64 (= A62), H66 (= H64), D67 (= D65), I68 (= I66), H69 (≠ M67), W108 (= W106), G110 (= G108), T132 (= T130), P133 (= P131), K253 (= K251)
P52045 Methylmalonyl-CoA decarboxylase; MMCD; Transcarboxylase; EC 4.1.1.- from Escherichia coli (strain K12) (see paper)
51% identity, 97% coverage: 10:259/259 of query aligns to 12:261/261 of P52045
- G110 (= G108) binding substrate
- T132 (= T130) binding substrate
- K253 (= K251) binding substrate
6n97A Methylmalonyl-coa decarboxylase in complex with 2-sulfonate-propionyl- amino(dethia)-coa (see paper)
51% identity, 97% coverage: 10:259/259 of query aligns to 11:260/260 of 6n97A
- active site: H65 (= H64), L70 (= L69), G109 (= G108), E112 (= E111), P132 (= P131), V137 (≠ I136), Y139 (= Y138), E227 (= E226), Y237 (≠ W236)
- binding (2R)-sulfonatepropionyl-amino(dethia)-CoA: L24 (vs. gap), K59 (= K58), A63 (= A62), H65 (= H64), D66 (= D65), I67 (= I66), W107 (= W106), G108 (= G107), G109 (= G108), T131 (= T130), P132 (= P131), L135 (≠ F134), Y139 (= Y138), F249 (= F248), K252 (= K251)
- binding (2S)-sulfonatepropionyl-amino(dethia)-CoA: L24 (vs. gap), K59 (= K58), A63 (= A62), H65 (= H64), D66 (= D65), I67 (= I66), W107 (= W106), G108 (= G107), G109 (= G108), T131 (= T130), P132 (= P131), L135 (≠ F134), Y139 (= Y138), F249 (= F248), K252 (= K251)
6n96A Methylmalonyl-coa decarboxylase in complex with 2-sulfonate-propionyl- oxa(dethia)-coa (see paper)
51% identity, 97% coverage: 10:259/259 of query aligns to 11:260/260 of 6n96A
- active site: H65 (= H64), L70 (= L69), G109 (= G108), E112 (= E111), P132 (= P131), V137 (≠ I136), Y139 (= Y138), E227 (= E226), Y237 (≠ W236)
- binding (2~{S})-1-[2-[3-[[(2~{R})-4-[[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-3,3-dimethyl-2-oxidanyl-butanoyl]amino]propanoylamino]ethoxy]-1-oxidanylidene-propane-2-sulfonic acid: K59 (= K58), A63 (= A62), H65 (= H64), D66 (= D65), I67 (= I66), H68 (≠ M67), W107 (= W106), G108 (= G107), G109 (= G108), T131 (= T130), P132 (= P131), L135 (≠ F134), V137 (≠ I136), Y139 (= Y138), F249 (= F248), K252 (= K251)
- binding (2~{R})-1-[2-[3-[[(2~{R})-4-[[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-3,3-dimethyl-2-oxidanyl-butanoyl]amino]propanoylamino]ethoxy]-1-oxidanylidene-propane-2-sulfonic acid: K59 (= K58), A63 (= A62), H65 (= H64), D66 (= D65), I67 (= I66), H68 (≠ M67), W107 (= W106), G108 (= G107), G109 (= G108), T131 (= T130), P132 (= P131), L135 (≠ F134), V137 (≠ I136), Y139 (= Y138), F249 (= F248), K252 (= K251)
6n95A Methylmalonyl-coa decarboxylase in complex with 2-sulfonate-propionyl- coa (see paper)
51% identity, 97% coverage: 10:259/259 of query aligns to 11:260/260 of 6n95A
- active site: H65 (= H64), L70 (= L69), G109 (= G108), E112 (= E111), P132 (= P131), V137 (≠ I136), Y139 (= Y138), E227 (= E226), Y237 (≠ W236)
- binding (2R)-sulfonatepropionyl-CoA: K23 (≠ R23), L24 (vs. gap), K59 (= K58), A63 (= A62), H65 (= H64), D66 (= D65), I67 (= I66), H68 (≠ M67), W107 (= W106), G108 (= G107), G109 (= G108), T131 (= T130), P132 (= P131), L135 (≠ F134), Y139 (= Y138), F249 (= F248), K252 (= K251)
- binding (2S)-sulfonatepropionyl-CoA: K23 (≠ R23), L24 (vs. gap), K59 (= K58), A63 (= A62), H65 (= H64), D66 (= D65), I67 (= I66), H68 (≠ M67), W107 (= W106), G108 (= G107), G109 (= G108), T131 (= T130), P132 (= P131), L135 (≠ F134), V137 (≠ I136), Y139 (= Y138), F249 (= F248), K252 (= K251)
6n94A Methylmalonyl-coa decarboxylase in complex with 2-nitronate-propionyl- amino(dethia)-coa (see paper)
51% identity, 97% coverage: 10:259/259 of query aligns to 11:260/260 of 6n94A
- active site: H65 (= H64), L70 (= L69), G109 (= G108), E112 (= E111), P132 (= P131), V137 (≠ I136), Y139 (= Y138), E227 (= E226), Y237 (≠ W236)
- binding [1-[2-[3-[[(2~{R})-4-[[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-3,3-dimethyl-2-oxidanyl-butanoyl]amino]propanoylamino]ethylamino]-1-oxidanylidene-propan-2-ylidene]-bis(oxidanidyl)azanium: K23 (≠ R23), L24 (vs. gap), A63 (= A62), H65 (= H64), D66 (= D65), I67 (= I66), H68 (≠ M67), W107 (= W106), G108 (= G107), G109 (= G108), T131 (= T130), P132 (= P131), Y139 (= Y138)
6n93A Methylmalonyl-coa decarboxylase in complex with 2-nitronate-propionyl- oxa(dethia)-coa (see paper)
51% identity, 97% coverage: 10:259/259 of query aligns to 11:260/260 of 6n93A
- active site: H65 (= H64), L70 (= L69), G109 (= G108), E112 (= E111), P132 (= P131), V137 (≠ I136), Y139 (= Y138), E227 (= E226), Y237 (≠ W236)
- binding [1-[2-[3-[[(2~{R})-4-[[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-3,3-dimethyl-2-oxidanyl-butanoyl]amino]propanoylamino]ethoxy]-1-oxidanylidene-propan-2-ylidene]-bis(oxidanidyl)azanium: L24 (vs. gap), A63 (= A62), H65 (= H64), D66 (= D65), I67 (= I66), H68 (≠ M67), W107 (= W106), T131 (= T130), L135 (≠ F134), F249 (= F248), K252 (= K251)
6n92F Methylmalonyl-coa decarboxylase in complex with 2-nitronate-propionyl- coa (see paper)
51% identity, 97% coverage: 10:259/259 of query aligns to 11:260/260 of 6n92F
- active site: H65 (= H64), L70 (= L69), G109 (= G108), E112 (= E111), P132 (= P131), V137 (≠ I136), Y139 (= Y138), E227 (= E226), Y237 (≠ W236)
- binding [1-[2-[3-[[(2~{R})-4-[[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-3,3-dimethyl-2-oxidanyl-butanoyl]amino]propanoylamino]ethylsulfanyl]-1-oxidanylidene-propan-2-ylidene]-bis(oxidanidyl)azanium: R22 (= R22), K23 (≠ R23), L24 (vs. gap), A63 (= A62), H65 (= H64), D66 (= D65), S105 (≠ G104), W107 (= W106), W107 (= W106), G108 (= G107), G109 (= G108), T127 (≠ S126), F128 (= F127), S129 (≠ T128), T131 (= T130), P132 (= P131), Y139 (= Y138), S164 (≠ Q163), P165 (≠ S164), F249 (= F248)
- binding (2E)-2-(hydroxyimino)propanoic acid: E240 (= E239), H260 (≠ E259)
6n92A Methylmalonyl-coa decarboxylase in complex with 2-nitronate-propionyl- coa (see paper)
51% identity, 97% coverage: 10:259/259 of query aligns to 11:260/260 of 6n92A
- active site: H65 (= H64), L70 (= L69), G109 (= G108), E112 (= E111), P132 (= P131), V137 (≠ I136), Y139 (= Y138), E227 (= E226), Y237 (≠ W236)
- binding [1-[2-[3-[[(2~{R})-4-[[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-3,3-dimethyl-2-oxidanyl-butanoyl]amino]propanoylamino]ethylsulfanyl]-1-oxidanylidene-propan-2-ylidene]-bis(oxidanidyl)azanium: L24 (vs. gap), A63 (= A62), H65 (= H64), D66 (= D65), I67 (= I66), H68 (≠ M67), W107 (= W106), G108 (= G107), G109 (= G108), T131 (= T130), P132 (= P131), Y139 (= Y138), F249 (= F248), K252 (= K251)
5jbxB Crystal structure of liuc in complex with coenzyme a and malonic acid (see paper)
32% identity, 97% coverage: 7:258/259 of query aligns to 10:260/261 of 5jbxB
- active site: A67 (≠ H64), R72 (≠ L69), L84 (≠ Y80), R88 (≠ E84), G112 (= G108), E115 (= E111), T134 (= T130), E135 (≠ P131), I140 (= I136), P142 (≠ Y138), G143 (≠ N139), A228 (= A219), L238 (≠ W236)
- binding coenzyme a: S24 (≠ D21), R25 (= R22), R26 (= R23), A28 (= A25), A65 (= A62), D68 (= D65), L69 (≠ I66), K70 (≠ M67), L110 (≠ W106), G111 (= G107), T134 (= T130), E135 (≠ P131), L138 (≠ F134), R168 (≠ S164)
5zaiC Crystal structure of 3-hydroxypropionyl-coa dehydratase from metallosphaera sedula (see paper)
32% identity, 95% coverage: 15:259/259 of query aligns to 17:259/259 of 5zaiC
- active site: A65 (≠ H64), F70 (≠ L69), S82 (≠ Y80), R86 (≠ E84), G110 (= G108), E113 (= E111), P132 (≠ T130), E133 (≠ P131), I138 (= I136), P140 (≠ Y138), G141 (≠ N139), A226 (≠ T224), F236 (≠ W236)
- binding coenzyme a: K24 (≠ R22), L25 (≠ R23), A63 (= A62), G64 (= G63), A65 (≠ H64), D66 (= D65), I67 (= I66), P132 (≠ T130), R166 (≠ S164), F248 (= F248), K251 (= K251)
5du6A Crystal structure of m. Tuberculosis echa6 bound to ligand gsk059a. (see paper)
28% identity, 96% coverage: 10:258/259 of query aligns to 9:241/242 of 5du6A
- active site: A61 (≠ H64), P71 (≠ Y80), I75 (≠ E84), A99 (≠ G108), Q102 (≠ E111), P121 (≠ T130), T122 (≠ P131), L127 (≠ I136), L129 (≠ Y138), D130 (≠ N139), P209 (≠ E226), W219 (= W236)
- binding (5R,7R)-5-(4-ethylphenyl)-N-(4-fluorobenzyl)-7-methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide: L74 (= L83), D82 (≠ Q91), D130 (≠ N139), W132 (≠ S141), A207 (≠ T224), K212 (≠ Q229), F215 (≠ R232)
5ducA Crystal structure of m. Tuberculosis echa6 bound to ligand gsk951a (see paper)
28% identity, 96% coverage: 10:258/259 of query aligns to 9:243/244 of 5ducA
- active site: A61 (≠ H64), D66 (= D75), P73 (≠ Y80), I77 (≠ E84), A101 (≠ G108), Q104 (≠ E111), P123 (≠ T130), T124 (≠ P131), L129 (≠ I136), L131 (≠ Y138), D132 (≠ N139), P211 (≠ E226), W221 (= W236)
- binding (5R,7S)-N-(1,3-benzodioxol-5-ylmethyl)-5-(4-ethylphenyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide: L76 (= L83), H80 (≠ I87), D84 (≠ Q91), Q104 (≠ E111), D132 (≠ N139), W134 (≠ S141), F217 (≠ R232)
5du4A Crystal structure of m. Tuberculosis echa6 bound to ligand gsk366a (see paper)
28% identity, 96% coverage: 10:258/259 of query aligns to 9:243/244 of 5du4A
- active site: A61 (≠ H64), D66 (= D75), P73 (≠ Y80), I77 (≠ E84), A101 (≠ G108), Q104 (≠ E111), P123 (≠ T130), T124 (≠ P131), L129 (≠ I136), L131 (≠ Y138), D132 (≠ N139), P211 (≠ E226), W221 (= W236)
- binding (5R,7S)-5-(4-ethylphenyl)-N-(4-methoxybenzyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide: L76 (= L83), I77 (≠ E84), H80 (≠ I87), D84 (≠ Q91), Q104 (≠ E111), D132 (≠ N139), W134 (≠ S141)
5dtwA Crystal structure of m. Tuberculosis echa6 bound to c20-coa (see paper)
28% identity, 96% coverage: 10:258/259 of query aligns to 9:243/244 of 5dtwA
- active site: A61 (≠ H64), D66 (= D75), P73 (≠ Y80), I77 (≠ E84), A101 (≠ G108), Q104 (≠ E111), P123 (≠ T130), T124 (≠ P131), L129 (≠ I136), L131 (≠ Y138), D132 (≠ N139), P211 (≠ E226), W221 (= W236)
- binding Arachinoyl-CoA: R18 (≠ N19), E20 (≠ D21), R21 (= R22), R21 (= R22), R22 (= R23), A24 (= A25), A59 (= A62), A61 (≠ H64), D62 (= D65), L63 (≠ I66), H80 (≠ I87), D84 (≠ Q91), G100 (= G107), A101 (≠ G108), Y127 (≠ F134), W134 (≠ S141)
Q8GYN9 1,4-dihydroxy-2-naphthoyl-CoA synthase, peroxisomal; DHNS; Enoyl-CoA hydratase/isomerase D; ECHID; Naphthoate synthase; EC 4.1.3.36 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
28% identity, 95% coverage: 11:256/259 of query aligns to 86:330/337 of Q8GYN9
Sites not aligning to the query:
- 20 H→V: Loss of peroxisomal targeting.
5dufA Crystal structure of m. Tuberculosis echa6 bound to ligand gsk729a (see paper)
28% identity, 96% coverage: 10:258/259 of query aligns to 10:244/245 of 5dufA
- active site: A62 (≠ H64), D67 (= D75), P74 (≠ Y80), I78 (≠ E84), A102 (≠ G108), Q105 (≠ E111), P124 (≠ T130), T125 (≠ P131), L130 (≠ I136), L132 (≠ Y138), D133 (≠ N139), P212 (≠ E226), W222 (= W236)
- binding (5R,7S)-5-(4-ethylphenyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxylic acid: L77 (= L83), I78 (≠ E84), H81 (≠ I87), D85 (≠ Q91), Q105 (≠ E111), D133 (≠ N139), W135 (≠ S141)
Q7CQ56 1,4-dihydroxy-2-naphthoyl-CoA synthase; DHNA-CoA synthase; EC 4.1.3.36 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
27% identity, 95% coverage: 10:256/259 of query aligns to 32:278/285 of Q7CQ56
2uzfA Crystal structure of staphylococcus aureus 1,4-dihydroxy-2-naphthoyl coa synthase (menb) in complex with acetoacetyl coa (see paper)
28% identity, 97% coverage: 7:256/259 of query aligns to 13:253/260 of 2uzfA
- active site: G70 (= G63), R80 (≠ G73), L84 (= L77), G108 (= G108), V111 (≠ E111), T130 (= T130), G131 (≠ P131), S136 (≠ I136), D138 (≠ Y138), A139 (≠ N139), A225 (≠ Q229), Y233 (≠ D237)
- binding acetoacetyl-coenzyme a: V28 (≠ R22), R29 (= R23), S68 (= S61), G69 (≠ A62), G70 (= G63), D71 (≠ H64), Y104 (≠ G104), G108 (= G108)
3q0jC Crystal structure of the mycobacterium tuberculosis crotonase in complex with the inhibitor acetoacetylcoa
29% identity, 98% coverage: 4:256/259 of query aligns to 6:254/255 of 3q0jC
- active site: A65 (≠ H64), M70 (≠ L69), T80 (≠ E84), F84 (≠ R88), G108 (= G108), E111 (= E111), P130 (≠ T130), E131 (≠ P131), V136 (≠ I136), P138 (≠ Y138), G139 (≠ N139), L224 (vs. gap), F234 (≠ W236)
- binding acetoacetyl-coenzyme a: Q23 (≠ D21), A24 (≠ R22), L25 (≠ R23), A27 (= A25), A63 (= A62), G64 (= G63), A65 (≠ H64), D66 (= D65), I67 (= I66), K68 (≠ M67), M70 (≠ L69), F84 (≠ R88), G107 (= G107), G108 (= G108), E111 (= E111), P130 (≠ T130), E131 (≠ P131), P138 (≠ Y138), G139 (≠ N139), M140 (≠ P140)
Query Sequence
>WP_013707330.1 NCBI__GCF_000195295.1:WP_013707330.1
MSLVIQEVRNAIGIITFDNYDRRNALSKAFIADIMTAMNSLLYEEVRVIIFRAHPGAKVW
SAGHDIMELERPGRDPLGYYDPLEKIIRAIQNCPTPVIALIEGGVWGGACELACICDILI
GGPNASFTITPSRFGIPYNPSGILHLINRCGLGAAKEMFFTAQSVNAERALRLGILNHLV
AATELEDFTYDLAGAIARNSPLSVSVIKEQLRIFSNALALNPETFERIQGLRRLVWDSED
YIEGKKAFLEKRAPIFKGE
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory