SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing WP_013707519.1 NCBI__GCF_000195295.1:WP_013707519.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

3bs8A Crystal structure of glutamate 1-semialdehyde aminotransferase complexed with pyridoxamine-5'-phosphate from bacillus subtilis (see paper)
58% identity, 99% coverage: 5:425/427 of query aligns to 7:426/430 of 3bs8A

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active site: V22 (= V20), Y145 (= Y143), E207 (= E205), D240 (= D238), M243 (≠ I241), K268 (= K266), G401 (≠ A400)
binding 4'-deoxy-4'-aminopyridoxal-5'-phosphate: G118 (= G116), T119 (= T117), Y145 (= Y143), H146 (= H144), E207 (= E205), N212 (= N210), D240 (= D238), V242 (= V240), K268 (= K266)

P23893 Glutamate-1-semialdehyde 2,1-aminomutase; GSA; Glutamate-1-semialdehyde aminotransferase; GSA-AT; EC 5.4.3.8 from Escherichia coli (strain K12) (see paper)
57% identity, 99% coverage: 2:423/427 of query aligns to 1:423/426 of P23893

query
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P23893

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K265 (= K266) mutation to R: 2% of wild-type activity.

Q42522 Glutamate-1-semialdehyde 2,1-aminomutase 2, chloroplastic; GSA 2; Glutamate-1-semialdehyde aminotransferase 2; GSA-AT 2; EC 5.4.3.8 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
55% identity, 99% coverage: 2:423/427 of query aligns to 48:469/472 of Q42522

query
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Q42522

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L

R92 (≠ I46) mutation to K: In gsa2-1; suppression of enf1 mutant pleiotropic developmental phenotypes; when associated with S-162.
G162 (= G116) mutation to S: In gsa2-1; suppression of enf1 mutant pleiotropic developmental phenotypes; when associated with K-92.

P42799 Glutamate-1-semialdehyde 2,1-aminomutase 1, chloroplastic; AtGSA1; GSA 1; Glutamate-1-semialdehyde aminotransferase 1; GSA-AT 1; EC 5.4.3.8 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
55% identity, 99% coverage: 2:423/427 of query aligns to 50:471/474 of P42799

query
sites
P42799

I

L

T

Q

H

K

S

S

E

E

Q

E

L

A

F

F

Q

N

Q

A

A

A

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R

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M

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P

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N

N

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G

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D

G

G

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Y

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E

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A

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A

M

A

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A

K

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A

A

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C

P

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A

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E

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E

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A

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A

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E

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M

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F

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N

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E

A

A

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M

S

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A

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A

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R

A

A

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N

R

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E

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I

I

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F

F

D

E

G

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A

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A

A

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A

A

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A

V

G

G

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P

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P

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D

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A

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A

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A

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L

K314 (= K266) modified: N6-(pyridoxal phosphate)lysine

5hdmB Crystal structure of arabidopsis thaliana glutamate-1-semialdehyde-2, 1-aminomutase (see paper)
55% identity, 99% coverage: 2:423/427 of query aligns to 4:425/428 of 5hdmB

query
sites
5hdmB

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G

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|
Y

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|
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G

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N

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G

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M

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G

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active site: V22 (= V20), Y145 (= Y143), E207 (= E205), D240 (= D238), M243 (≠ I241), K268 (= K266), A402 (= A400)
binding pyridoxal-5'-phosphate: G118 (= G116), T119 (= T117), Y145 (= Y143), E207 (= E205), N212 (= N210), D240 (= D238), V242 (= V240), M243 (≠ I241), K268 (= K266)
binding 4'-deoxy-4'-aminopyridoxal-5'-phosphate: G118 (= G116), T119 (= T117), Y145 (= Y143), E207 (= E205), N212 (= N210), D240 (= D238), V242 (= V240), M243 (≠ I241), K268 (= K266)

5hdmA Crystal structure of arabidopsis thaliana glutamate-1-semialdehyde-2, 1-aminomutase (see paper)
55% identity, 99% coverage: 2:423/427 of query aligns to 4:425/428 of 5hdmA

query
sites
5hdmA

I

L

T

Q

H

K

S

S

E

E

Q

E

L

A

F

F

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N

Q

A

A

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N

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L

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M

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P

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|
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K

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K

K

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|
Y

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G
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G

H

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A

A

D

N

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A

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A

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|
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A

T

L

I

S

A

A

A

G

A

E

E

K

R

A

V

L

L

active site: V22 (= V20), Y145 (= Y143), E207 (= E205), D240 (= D238), M243 (≠ I241), K268 (= K266), A402 (= A400)
binding 4'-deoxy-4'-aminopyridoxal-5'-phosphate: G118 (= G116), T119 (= T117), Y145 (= Y143), G147 (= G145), E207 (= E205), N212 (= N210), D240 (= D238), V242 (= V240), K268 (= K266)

3k28A Crystal structure of a glutamate-1-semialdehyde aminotransferase from bacillus anthracis with bound pyridoxal 5'phosphate
58% identity, 94% coverage: 9:411/427 of query aligns to 11:407/423 of 3k28A

query
sites
3k28A

F

F

Q

E

Q

E

A

A

R

Q

R

D

L

L

M

M

P

P

G

G

G

G

V
|
V

N

N

S

S

P

P

V

V

R

R

A

A

W

F

R

K

A

S

M

V

G

G

M

M

S

N

P

P

R

L

F

F

I

M

A

E

R

R

A

G

Q

K

G

G

P

S

H

K

I

V

I

Y

D

D

V

I

D

D

G

G

N

N

V

E

Y

Y

L

I

D

D

F

Y

V

V

G

L

S

S

W

W

G

G

P

P

M

L

I

I

V

H

G

G

H

H

A

A

H

N

P

D

K

R

V

V

L

V

E

E

A

A

V

L

Q

K

K

A

A

V

A

A

A

E

A

R

G

G

T

T

S

S

Y

F

G

G

A

A

P

P

T

T

P

E

A

I

E

E

V

N

E

K

L

L

A

A

D

K

L

L

L

V

I
|
I

D

E

A

R

V
|
V

S
x
P

G

S

L
x
I

E

E

M

I

V

V

R

R

L

M

V

V

N

N

S

S

G
|
G

T
|
T

E

E

A

A

T

T

M

M

S

S

A

A

L

L

R

R

L

L

A

A

R

R

A

G

A

Y

T

T

G

G

R

R

K

N

K

K

I

I

I

L

K

K

F

F

D

I

G

G

G

C

Y
|
Y

H
|
H

G
|
G

H

H

A

G

D

D

T

S

L

L

L

L

V

I

Q

K

A

A

G

G

S

S

G

G

V

V

L

-

T

-

Q

-

G

-

I

-

P

P

G

D

S

S

P

P

G

G

V

V

P

P

E

E

E

G

I

V

A

A

S

K

L

N

T

T

I

I

S

T

V

V

A

A

Y

Y

N

N

D

D

L

L

N

E

A

S

V

V

V

K

Q

Y

A

A

M

F

E

E

H

Q

H

F

A

G

G

D

D

D

I

I

A

A

A

C

L

V

I

I

V

V

E
|
E

P

P

V

V

A

A

G

G

N

N

M

M

G

G

V

V

V

V

L

P

P

P

Q

Q

P

P

D

G

F

F

L

L

P

E

G

G

L

L

R

R

R

E

L

V

C

T

D

E

Q

Q

R

N

S

G

I

A

V

L

L

L

I

I

F

F

D
|
D

E

E

V
|
V

I
x
M

T

T

G

G

F

F

R

R

V

V

A

A

W

Y

G

N

G

C

A

G

Q

Q

K

G

K

Y

F

Y

G

G

V

V

T

T

P

P

D

D

L

L

T

T

C

C

L

L

G

G

K
|
K

V

V

I

I

G

G

G

G

G

G

L

L

P

P

V

V

G

G

A

A

Y

Y

G

G

G

G

R

K

R

A

D

E

L

I

M

M

E

R

Q

Q

M

V

A

A

P

P

V

S

G

G

P

P

V

I

Y

Y

Q

Q

A

A

G

G

T

T

L

L

S

S

G

G

N

N

P

P

L

L

A

A

M

M

A

A

A

A

G

G

L

Y

A

E

T

T

L

L

K

V

I

Q

L

L

A

T

E

-

P

P

G

E

T

S

Y

Y

E

V

D

E

L

F

E

E

E

R

K

K

G

A

C

E

Y

M

F

L

T

E

E

A

Q

G

I

L

S

R

A

K

L

A

A

A

H

E

L

K

M

H

K

G

L

I

P

P

L

H

R

H

I

I

N

N

R

R

E

A

G

G

S

S

M

M

F

I

T

G

I

I

F

F

F

F

T

T

D

D

C

E

P

P

V

V

N

I

N

N

L

Y

V

D

E

A

A

A

Q

K

T

S

S

S

D

N

T

L

G

Q

R

F

F

F

Q

A

Q

A

F

Y

F

Y

Q

R

A

E

M

M

L

V

A

E

Q

Q

G

G

V

V

Y

F

L

L

P

P

P

P

S

S

Q

Q

F

F

E

E

A
x
G

W

L

F

F

V

L

S

S

L

T

A

V

H

H

S

S

P

D

E

A

D

D

active site: V22 (= V20), Y145 (= Y143), E202 (= E205), D235 (= D238), M238 (≠ I241), K263 (= K266), G396 (≠ A400)
binding calcium ion: I103 (= I101), V106 (= V104), P107 (≠ S105), I109 (≠ L107)
binding pyridoxal-5'-phosphate: G118 (= G116), T119 (= T117), Y145 (= Y143), H146 (= H144), G147 (= G145), E202 (= E205), D235 (= D238), V237 (= V240), M238 (≠ I241), K263 (= K266)

3fqaA Gabaculien complex of gabaculine resistant gsam version (see paper)
53% identity, 98% coverage: 5:423/427 of query aligns to 5:423/426 of 3fqaA

query
sites
3fqaA

S

S

E

D

Q

E

L

I

F

F

Q

A

Q

A

A

A

R

Q

R

K

L

L

M

M

P

P

G

G

G

G

V
|
V

N

S

S
|
S

P

P

V

V

R
|
R

A

A

W

F

R

K

A

S

M

V

G

G

M

G

S

Q

P

P

R

I

F

V

I

F

A

D

R

R

A

V

Q

K

G

D

P

A

H

Y

I

A

I

W

D

D

V

V

D

D

G

G

N

N

V

R

Y

Y

L

I

D

D

F

Y

V

V

G

G

S

T

W
|
W

G

G

P

P

M

A

I

I

V

C

G

G

H

H

A

A

H

H

P

P

K

E

V

V

L

I

E

E

A

A

V

L

Q

K

K

V

A

A

A

M

A

E

A

K

G

G

T

T

S

S

Y

F

G

G

A

A

P

P

T

C

P

A

A

L

E

E

V

N

E

V

L

L

A

A

D

E

L

M

L

V

I

N

D

D

A

A

V

V

S

P

G

S

L

I

E

E

M

M

V

V

R

R

L

F

V

V

N

N

S

S

G
|
G

T
|
T

E

E

A

A

T

C

M

M

S

A

A

V

L

L

R

R

L

L

A

M

R

R

A

A

A

Y

T

T

G

G

R

R

K

D

K

K

I

I

I

I

K

K

F

F

D

E

G

G

G

C

Y
|
Y

H

H

G

G

H

H

A

A

D

D

T

M

L

F

L

L

V

V

Q

K

A

A

G

G

S

S

G

G

V

V

L

A

T

T

Q

L

G

G

I

L

P

P

G

S

S

S

P

P

G

G

V

V

P

P

E

K

E

K

I

T

A

T

S

A

L

N

T

T

I

L

S

T

V

T

A

P

Y

Y

N

N

D

D

L

L

N

E

A

A

V

V

V

K

Q

A

A

L

M

F

E

A

H

E

H

N

A

P

G

G

D

E

I

I

A

A

A

G

L

V

I

I

V

L

E
|
E

P

P

V

I

A

V

G

G

N
|
N

M

S

G

G

V

F

V

I

L

V

P

P

Q

D

P

A

D

G

F

F

L

L

P

E

G

G

L

L

R

R

R

E

L

I

C

T

D

L

Q

E

R

H

S

D

I

A

V

L

L

L

I

V

F

F

D
|
D

E

E

V
|
V

I
|
I

T

T

G

G

F

F

R

R

V

I

A

A

W

Y

G

G

G

G

A

V

Q

Q

K

E

K

K

F

F

G

G

V

V

T

T

P

P

D

D

L

L

T

T

C

T

L

L

G

G

K
|
K

V

I

I

I

G

G

G

G

G

G

L

L

P

P

V

V

G

G

A

A

Y

Y

G

G

G

G

R

K

R

R

D

E

L

I

M

M

E

Q

Q

L

M

V

A

A

P

P

V

A

G

G

P

P

V

M

Y

Y

Q

Q

A

A

G

G

T

T

L

L

S

S

G

G

N

N

P

P

L

L

A

A

M

M

A

T

A

A

G

G

L

I

A

K

T

T

L

L

K

E

I

L

L

L

A

R

E

Q

P

P

G

G

T

T

Y

Y

E

E

D

Y

L

L

E

D

E

Q

K

I

G

T

C

K

Y

R

F

L

T

S

E

D

Q

G

I

L

S

L

A

A

L

I

A

A

H

Q

L

E

M

T

K

G

L

H

P

A

L

A

R

C

I

G

N

G

R

Q

E

V

G

S

S

G

M

M

F

F

T

G

I

F

F

F

F

F

T

T

D

E

C

G

P

P

V

V

N

H

N

N

L

Y

V

E

E

D

A

A

Q

K

T

K

S

S

D

D

T

L

G

Q

R

K

F

F

Q

S

Q

R

F

F

F

H

Q

R

A

G

M

M

L

L

A

E

Q

Q

G

G

V

I

Y

Y

L

L

P

A

P

P

S

S

Q

Q

F

F

E

E

A
|
A

W

G

F

F

V

T

S

S

L

L

A

A

H

H

S

T

P

E

E

E

D

D

L

I

Q

D

K

A

A

T

L

L

S

A

A

A

G

A

E

R

K

T

A

V

L

M

active site: V20 (= V20), Y143 (= Y143), D238 (= D238), I241 (= I241), K266 (= K266), A400 (= A400)
binding 3-aminobenzoic acid: S22 (= S22), R25 (= R25), W60 (= W60)
binding 4'-deoxy-4'-aminopyridoxal-5'-phosphate: G116 (= G116), T117 (= T117), Y143 (= Y143), E205 (= E205), N210 (= N210), D238 (= D238), V240 (= V240), I241 (= I241)

2gsaB Crystal structure of glutamate-1-semialdehyde aminomutase (aminotransferase, wild-type form) (see paper)
53% identity, 98% coverage: 5:423/427 of query aligns to 6:424/427 of 2gsaB

query
sites
2gsaB

S

S

E

D

Q

E

L

I

F

F

Q

A

Q

A

A

A

R

Q

R

K

L

L

M

M

P

P

G

G

G

G

V
|
V

N

S

S

S

P

P

V

V

R

R

A

A

W

F

R

K

A

S

M

V

G

G

M

G

S

Q

P

P

R

I

F

V

I

F

A

D

R

R

A

V

Q

K

G

D

P

A

H

Y

I

A

I

W

D

D

V

V

D

D

G

G

N

N

V

R

Y

Y

L

I

D

D

F

Y

V

V

G

G

S

T

W

W

G

G

P

P

M

A

I

I

V

C

G

G

H

H

A

A

H

H

P

P

K

E

V

V

L

I

E

E

A

A

V

L

Q

K

K

V

A

A

A

M

A

E

A

K

G

G

T

T

S

S

Y

F

G

G

A

A

P

P

T

C

P

A

A

L

E

E

V

N

E

V

L

L

A

A

D

E

L

M

L

V

I

N

D

D

A

A

V

V

S

P

G

S

L

I

E

E

M

M

V

V

R

R

L

F

V

V

N

N

S

S

G
|
G

T
|
T

E

E

A

A

T

C

M

M

S

A

A

V

L

L

R

R

L

L

A

M

R

R

A

A

A

Y

T

T

G

G

R

R

K

D

K

K

I

I

I

I

K

K

F

F

D

E

G

G

G

C

Y
|
Y

H

H

G

G

H

H

A

A

D

D

T

M

L

F

L

L

V

V

Q

K

A

A

G

G

S

S

G

G

V

V

L

A

T

T

Q

L

G

G

I

L

P

P

G

S

S

S

P

P

G

G

V

V

P

P

E

K

E

K

I

T

A

T

S

A

L

N

T

T

I

L

S

T

V

T

A

P

Y

Y

N

N

D

D

L

L

N

E

A

A

V

V

V

K

Q

A

A

L

M

F

E

A

H

E

H

N

A

P

G

G

D

E

I

I

A

A

A

G

L

V

I

I

V

L

E
|
E

P

P

V

I

A

V

G

G

N
|
N

M

S

G

G

V

F

V

I

L

V

P

P

Q

D

P

A

D

G

F

F

L

L

P

E

G

G

L

L

R

R

R

E

L

I

C

T

D

L

Q

E

R

H

S

D

I

A

V

L

L

L

I

V

F

F

D
|
D

E

E

V
|
V

I
x
M

T

T

G

G

F

F

R

R

V

I

A

A

W

Y

G

G

G

G

A

V

Q

Q

K

E

K

K

F

F

G

G

V

V

T

T

P

P

D

D

L

L

T

T

C

T

L

L

G

G

K
|
K

V

I

I

I

G

G

G

G

G

G

L

L

P

P

V

V

G

G

A

A

Y

Y

G

G

G

G

R

K

R

R

D

E

L

I

M

M

E

Q

Q

L

M

V

A

A

P

P

V

A

G

G

P

P

V

M

Y

Y

Q

Q

A

A

G

G

T

T

L

L

S

S

G

G

N

N

P

P

L

L

A

A

M

M

A

T

A

A

G

G

L

I

A

K

T

T

L

L

K

E

I

L

L

L

A

R

E

Q

P

P

G

G

T

T

Y

Y

E

E

D

Y

L

L

E

D

E

Q

K

I

G

T

C

K

Y

R

F

L

T

S

E

D

Q

G

I

L

S

L

A

A

L

I

A

A

H

Q

L

E

M

T

K

G

L

H

P

A

L

A

R

C

I

G

N

G

R

Q

E

V

G

S

S

G

M

M

F

F

T

G

I

F

F

F

F

F

T

T

D

E

C

G

P

P

V

V

N

H

N

N

L

Y

V

E

E

D

A

A

Q

K

T

K

S

S

D

D

T

L

G

Q

R

K

F

F

Q

S

Q

R

F

F

F

H

Q

R

A

G

M

M

L

L

A

E

Q

Q

G

G

V

I

Y

Y

L

L

P

A

P

P

S

S

Q

Q

F

F

E

E

A
|
A

W

G

F

F

V

T

S

S

L

L

A

A

H

H

S

T

P

E

E

E

D

D

L

I

Q

D

K

A

A

T

L

L

S

A

A

A

G

A

E

R

K

T

A

V

L

M

active site: V21 (= V20), Y144 (= Y143), E206 (= E205), D239 (= D238), M242 (≠ I241), K267 (= K266), A401 (= A400)
binding pyridoxal-5'-phosphate: G117 (= G116), T118 (= T117), Y144 (= Y143), E206 (= E205), N211 (= N210), D239 (= D238), V241 (= V240), M242 (≠ I241), K267 (= K266)

2gsaA Crystal structure of glutamate-1-semialdehyde aminomutase (aminotransferase, wild-type form) (see paper)
53% identity, 98% coverage: 5:423/427 of query aligns to 6:424/427 of 2gsaA

query
sites
2gsaA

S

S

E

D

Q

E

L

I

F

F

Q

A

Q

A

A

A

R

Q

R

K

L

L

M

M

P

P

G

G

G

G

V
|
V

N

S

S

S

P

P

V

V

R

R

A

A

W

F

R

K

A

S

M

V

G

G

M

G

S

Q

P

P

R

I

F

V

I

F

A

D

R

R

A

V

Q

K

G

D

P

A

H

Y

I

A

I

W

D

D

V

V

D

D

G

G

N

N

V

R

Y

Y

L

I

D

D

F

Y

V

V

G

G

S

T

W

W

G

G

P

P

M

A

I

I

V

C

G

G

H

H

A

A

H

H

P

P

K

E

V

V

L

I

E

E

A

A

V

L

Q

K

K

V

A

A

A

M

A

E

A

K

G

G

T

T

S

S

Y

F

G

G

A

A

P

P

T

C

P

A

A

L

E

E

V

N

E

V

L

L

A

A

D

E

L

M

L

V

I

N

D

D

A

A

V

V

S

P

G

S

L

I

E

E

M

M

V

V

R

R

L

F

V

V

N

N

S

S

G
|
G

T
|
T

E

E

A

A

T

C

M

M

S

A

A

V

L

L

R

R

L

L

A

M

R

R

A

A

A

Y

T

T

G

G

R

R

K

D

K

K

I

I

I

I

K

K

F

F

D

E

G

G

G

C

Y
|
Y

H
|
H

G
|
G

H

H

A

A

D

D

T

M

L

F

L

L

V

V

Q

K

A

A

G

G

S

S

G

G

V

V

L

A

T

T

Q

L

G

G

I

L

P

P

G

S

S

S

P

P

G

G

V

V

P

P

E

K

E

K

I

T

A

T

S

A

L

N

T

T

I

L

S

T

V

T

A

P

Y

Y

N

N

D

D

L

L

N

E

A

A

V

V

V

K

Q

A

A

L

M

F

E

A

H

E

H

N

A

P

G

G

D

E

I

I

A

A

A

G

L

V

I

I

V

L

E
|
E

P

P

V

I

A

V

G

G

N
|
N

M

S

G

G

V

F

V

I

L

V

P

P

Q

D

P

A

D

G

F

F

L

L

P

E

G

G

L

L

R

R

R

E

L

I

C

T

D

L

Q

E

R

H

S

D

I

A

V

L

L

L

I

V

F

F

D
|
D

E

E

V
|
V

I
x
M

T

T

G

G

F

F

R

R

V

I

A

A

W

Y

G

G

G

G

A

V

Q

Q

K

E

K

K

F

F

G

G

V

V

T

T

P

P

D

D

L

L

T

T

C

T

L

L

G

G

K
|
K

V

I

I

I

G

G

G

G

G

G

L

L

P

P

V

V

G

G

A

A

Y

Y

G

G

G

G

R

K

R

R

D

E

L

I

M

M

E

Q

Q

L

M

V

A

A

P

P

V

A

G

G

P

P

V

M

Y

Y

Q

Q

A

A

G

G

T

T

L

L

S

S

G

G

N

N

P

P

L

L

A

A

M

M

A

T

A

A

G

G

L

I

A

K

T

T

L

L

K

E

I

L

L

L

A

R

E

Q

P

P

G

G

T

T

Y

Y

E

E

D

Y

L

L

E

D

E

Q

K

I

G

T

C

K

Y

R

F

L

T

S

E

D

Q

G

I

L

S

L

A

A

L

I

A

A

H

Q

L

E

M

T

K

G

L

H

P

A

L

A

R

C

I

G

N

G

R

Q

E

V

G

S

S

G

M

M

F

F

T

G

I

F

F

F

F

F

T

T

D

E

C

G

P

P

V

V

N

H

N

N

L

Y

V

E

E

D

A

A

Q

K

T

K

S

S

D

D

T

L

G

Q

R

K

F

F

Q

S

Q

R

F

F

F

H

Q

R

A

G

M

M

L

L

A

E

Q

Q

G

G

V

I

Y

Y

L

L

P

A

P

P

S

S

Q

Q

F

F

E

E

A
|
A

W

G

F

F

V

T

S

S

L

L

A

A

H

H

S

T

P

E

E

E

D

D

L

I

Q

D

K

A

A

T

L

L

S

A

A

A

G

A

E

R

K

T

A

V

L

M

active site: V21 (= V20), Y144 (= Y143), E206 (= E205), D239 (= D238), M242 (≠ I241), K267 (= K266), A401 (= A400)
binding 4'-deoxy-4'-aminopyridoxal-5'-phosphate: G117 (= G116), T118 (= T117), Y144 (= Y143), H145 (= H144), G146 (= G145), N211 (= N210), D239 (= D238), V241 (= V240), K267 (= K266)

3usfA Crystal structure of dava-4
53% identity, 98% coverage: 5:423/427 of query aligns to 6:424/427 of 3usfA

query
sites
3usfA

S

S

E

D

Q

E

L

I

F

F

Q

A

Q

A

A

A

R

Q

R

K

L

L

M

M

P

P

G

G

G

G

V
|
V

N

S

S
|
S

P

P

V
|
V

R

R

A

A

W

F

R

K

A

S

M

V

G

G

M

G

S

Q

P

P

R

I

F

V

I

F

A

D

R

R

A

V

Q

K

G

D

P

A

H

Y

I

A

I

W

D

D

V

V

D

D

G

G

N

N

V

R

Y

Y

L

I

D

D

F

Y

V

V

G

G

S

T

W

W

G

G

P

P

M

A

I

I

V

C

G

G

H

H

A

A

H

H

P

P

K

E

V

V

L

I

E

E

A

A

V

L

Q

K

K

V

A

A

A

M

A

E

A

K

G

G

T

T

S

S

Y

F

G

G

A

A

P

P

T

C

P

A

A

L

E

E

V

N

E

V

L

L

A

A

D

E

L

M

L

V

I

N

D

D

A

A

V

V

S

P

G

S

L

I

E

E

M

M

V

V

R

R

L

F

V

V

N

N

S

S

G
|
G

T
|
T

E

E

A

A

T

C

M

M

S

A

A

V

L

L

R

R

L

I

A

M

R

R

A

A

A

Y

T

T

G

G

R

R

K

D

K

K

I

I

I

I

K

K

F

F

D

E

G

G

G

C

Y
|
Y

H

H

G

G

H

H

A

A

D

D

T

M

L

F

L

L

V

V

Q

K

A

A

G

G

S
|
S

G

G

V

V

L

A

T

T

Q

L

G

G

I

L

P

P

G

S

S

S

P

P

G

G

V

V

P

P

E

K

E

K

I

T

A

T

S

A

L

N

T

T

I

L

S

T

V

T

A

P

Y

Y

N

N

D

D

L

L

N

E

A

A

V

V

V

K

Q

A

A

L

M

F

E

A

H

E

H

N

A

P

G

G

D

E

I

I

A

A

A

G

L

V

I

I

V

L

E

E

P

P

V

I

A

V

G

G

N
|
N

M

S

G

G

V

F

V

I

L

V

P

P

Q

D

P

A

D

G

F

F

L

L

P

E

G

G

L

L

R

R

R

E

L

I

C

T

D

L

Q

E

R

H

S

D

I

A

V

L

L

L

I

V

F

F

D
|
D

E

E

V
|
V

I
x
M

T

T

G

G

F

F

R

R

V

I

A

A

W

Y

G

G

G

G

A

V

Q

Q

K

E

K

K

F

F

G

G

V

V

T

T

P

P

D

D

L

L

T

T

C

T

L

L

G

G

K
|
K

V

I

I

I

G

G

G

G

G

G

L

L

P

P

V

V

G

G

A

A

Y

Y

G

G

G

G

R

K

R

R

D

E

L

I

M

M

E

Q

Q

L

M

V

A

A

P

P

V

A

G

G

P

P

V

M

Y

Y

Q

Q

A

A

G

G

T

T

L

L

S

S

G

G

N

N

P

P

L

L

A

A

M

M

A

T

A

A

G

G

L

I

A

K

T

T

L

L

K

E

I

L<