SitesBLAST
Comparing WP_013707581.1 NCBI__GCF_000195295.1:WP_013707581.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
6bwcC X-ray structure of pen from bacillus thuringiensis (see paper)
43% identity, 95% coverage: 6:342/354 of query aligns to 2:326/327 of 6bwcC
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G12 (= G16), T14 (≠ A18), G15 (= G19), T16 (= T20), I17 (≠ V21), S37 (≠ D41), R38 (≠ N42), S39 (≠ N43), D63 (= D65), I64 (= I66), V83 (≠ T85), A84 (= A86), K87 (= K89), T125 (= T127), S127 (= S129), Y137 (≠ M139), K141 (= K143), F167 (= F169), V170 (= V172), S173 (= S175), R174 (= R176)
- binding uridine-diphosphate-n-acetylglucosamine: K87 (= K89), H88 (= H90), S127 (= S129), N128 (≠ D130), Y137 (≠ M139), N169 (= N171), S176 (= S178), V177 (= V179), L180 (= L182), T192 (= T194), T194 (= T196), M198 (= M200), R200 (= R202), L234 (≠ I236), E265 (= E269)
O25511 UDP-N-acetylglucosamine 4,6-dehydratase (inverting); Pseudaminic acid biosynthesis protein B; UDP-GlcNAc-inverting 4,6-dehydratase; EC 4.2.1.115 from Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) (see paper)
38% identity, 87% coverage: 2:308/354 of query aligns to 3:294/333 of O25511
- TGSF 19:22 (≠ AGTV 18:21) binding NADP(+)
- SRDELK 43:48 (≠ QPGELR 33:38) binding NADP(+)
- DV 67:68 (≠ DI 65:66) binding NADP(+)
- A87 (≠ T85) binding NADP(+)
- K91 (= K89) binding NADP(+)
- LS 129:130 (≠ TS 127:128) binding NADP(+)
- K133 (= K131) mutation K->A,E: Loss of activity.
- Y141 (≠ M139) binding NADP(+)
- K145 (= K143) binding NADP(+)
- VVGSR 174:178 (≠ VLGSR 172:176) binding NADP(+)
2gnaA Crystal structure of udp-glcnac inverting 4,6-dehydratase in complex with NADP and udp-gal (see paper)
39% identity, 85% coverage: 9:308/354 of query aligns to 6:290/329 of 2gnaA
- binding galactose-uridine-5'-diphosphate: K87 (= K89), S176 (= S178), V177 (= V179), T195 (= T196), M199 (= M200), R201 (= R202), M235 (≠ I236), R254 (≠ K266), E257 (= E269)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G13 (= G16), T15 (≠ A18), G16 (= G19), S17 (≠ T20), F18 (≠ V21), S39 (≠ Q33), R40 (≠ P34), D41 (≠ G35), K44 (≠ R38), D63 (= D65), V64 (≠ I66), A83 (≠ T85), A84 (= A86), A85 (= A87), K87 (= K89), L125 (≠ T127), S126 (= S128), Y137 (≠ M139), K141 (= K143), Y167 (≠ F169), G168 (= G170), V170 (= V172)
2gn9A Crystal structure of udp-glcnac inverting 4,6-dehydratase in complex with NADP and udp-glc (see paper)
39% identity, 85% coverage: 9:308/354 of query aligns to 6:290/329 of 2gn9A
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G13 (= G16), T15 (≠ A18), G16 (= G19), S17 (≠ T20), F18 (≠ V21), R40 (≠ P34), D41 (≠ G35), K44 (≠ R38), D63 (= D65), V64 (≠ I66), A83 (≠ T85), A84 (= A86), A85 (= A87), K87 (= K89), L125 (≠ T127), S126 (= S128), K141 (= K143), Y167 (≠ F169), G168 (= G170), V170 (= V172), R174 (= R176)
- binding uridine-5'-diphosphate-glucose: K87 (= K89), T127 (≠ S129), K129 (= K131), Y137 (≠ M139), N169 (= N171), S176 (= S178), V177 (= V179), P193 (≠ T194), T195 (= T196), M199 (= M200), R201 (= R202), M235 (≠ I236), R254 (≠ K266), E257 (= E269)
2gn6A Crystal structure of udp-glcnac inverting 4,6-dehydratase in complex with NADP and udp-glcnac (see paper)
39% identity, 85% coverage: 9:308/354 of query aligns to 6:290/329 of 2gn6A
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G13 (= G16), T15 (≠ A18), G16 (= G19), S17 (≠ T20), F18 (≠ V21), R40 (≠ P34), D41 (≠ G35), K44 (≠ R38), D63 (= D65), V64 (≠ I66), A84 (= A86), A85 (= A87), K87 (= K89), S126 (= S128), Y137 (≠ M139), K141 (= K143), Y167 (≠ F169), G168 (= G170), V170 (= V172), S173 (= S175), R174 (= R176)
- binding uridine-diphosphate-n-acetylglucosamine: K87 (= K89), D128 (= D130), K129 (= K131), N169 (= N171), G175 (= G177), S176 (= S178), V177 (= V179), P193 (≠ T194), I194 (≠ L195), M199 (= M200), R201 (= R202), M235 (≠ I236), R254 (≠ K266), E257 (= E269)
2gn4A Crystal structure of udp-glcnac inverting 4,6-dehydratase in complex with NADPH and udp-glcnac (see paper)
39% identity, 85% coverage: 9:308/354 of query aligns to 6:290/329 of 2gn4A
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: G13 (= G16), T15 (≠ A18), G16 (= G19), S17 (≠ T20), F18 (≠ V21), S39 (≠ Q33), R40 (≠ P34), D41 (≠ G35), K44 (≠ R38), D63 (= D65), V64 (≠ I66), A83 (≠ T85), A84 (= A86), A85 (= A87), K87 (= K89), T102 (= T104), L125 (≠ T127), S126 (= S128), T127 (≠ S129), Y137 (≠ M139), K141 (= K143), Y167 (≠ F169), G168 (= G170), V170 (= V172), S173 (= S175), R174 (= R176)
- binding uridine-diphosphate-n-acetylglucosamine: K87 (= K89), T127 (≠ S129), D128 (= D130), K129 (= K131), Y137 (≠ M139), N169 (= N171), S176 (= S178), V177 (= V179), P193 (≠ T194), T195 (= T196), M199 (= M200), R201 (= R202), M235 (≠ I236), R254 (≠ K266), E257 (= E269)
2gn8A Crystal structure of udp-glcnac inverting 4,6-dehydratase in complex with NADP and udp (see paper)
39% identity, 85% coverage: 9:308/354 of query aligns to 4:288/327 of 2gn8A
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G11 (= G16), T13 (≠ A18), G14 (= G19), S15 (≠ T20), F16 (≠ V21), S37 (≠ Q33), R38 (≠ P34), D39 (≠ G35), K42 (≠ R38), D61 (= D65), V62 (≠ I66), A81 (≠ T85), A82 (= A86), A83 (= A87), K85 (= K89), T100 (= T104), L123 (≠ T127), S124 (= S128), K139 (= K143), Y165 (≠ F169), G166 (= G170), V168 (= V172), S171 (= S175), R172 (= R176)
- binding uridine-5'-diphosphate: K127 (= K131), N167 (= N171), V175 (= V179), P191 (≠ T194), I192 (≠ L195), T193 (= T196), M197 (= M200), R199 (= R202), M233 (≠ I236), R252 (≠ K266)
4j2oC Crystal structure of NADP-bound wbjb from a. Baumannii community strain d1279779 (see paper)
40% identity, 82% coverage: 7:296/354 of query aligns to 2:284/316 of 4j2oC
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G11 (= G16), T13 (≠ A18), G14 (= G19), S15 (≠ T20), F16 (≠ V21), S36 (≠ D41), R37 (≠ N42), D38 (≠ N43), K41 (≠ E46), D60 (= D65), V61 (≠ I66), A80 (≠ T85), A81 (= A86), A82 (= A87), K84 (= K89), T99 (= T104), L122 (≠ T127), K138 (= K143), Y164 (≠ F169)
3w1vA Crystal structure of capsular polysaccharide synthesizing enzyme cape from staphylococcus aureus in complex with inihibitor (see paper)
34% identity, 94% coverage: 7:338/354 of query aligns to 11:335/347 of 3w1vA
- binding [(2R,3S,4R,5R,6R)-5-acetamido-6-[[[(2R,3S,4R,5R)-5-[2,4-bis(oxidanylidene)pyrimidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-3,4-bis(oxidanyl)oxan-2-yl]methylimino-azanylidene-azanium: K93 (= K89), Q94 (≠ H90), N175 (= N171), S179 (= S175), R180 (= R176), S182 (= S178), V183 (= V179), L186 (= L182), T198 (= T194), I199 (≠ L195), T200 (= T196), M204 (= M200), R206 (= R202), V240 (≠ I236), R263 (≠ K266), E266 (= E269)
4g5hA Crystal structure of capsular polysaccharide synthesizing enzyme cape from staphylococcus aureus in complex with by-product (see paper)
34% identity, 94% coverage: 7:338/354 of query aligns to 11:335/346 of 4g5hA
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G20 (= G16), T22 (≠ A18), G23 (= G19), S24 (≠ T20), F25 (≠ V21), S45 (≠ D41), R46 (≠ N42), D47 (≠ N43), K50 (≠ E46), D69 (= D65), V70 (≠ I66), A89 (≠ T85), A90 (= A86), A91 (= A87), K93 (= K89), L131 (≠ T127), T133 (≠ S129), K147 (= K143), Y173 (≠ F169)
- binding [(2R,3R,4R,6R)-3-acetamido-6-methyl-4-oxidanyl-5-oxidanylidene-oxan-2-yl] [[(2R,3S,4R,5R)-5-[2,4-bis(oxidanylidene)pyrimidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] hydrogen phosphate: Q94 (≠ H90), V95 (= V91), K135 (= K131), N175 (= N171), S182 (= S178), V183 (= V179), L186 (= L182), T198 (= T194), T200 (= T196), M204 (= M200), V240 (≠ I236), R263 (≠ K266), E266 (= E269), Y278 (≠ M281), S313 (≠ P318), Y314 (= Y319), E315 (≠ A320), Y316 (≠ S321), N320 (≠ S325)
3vvcA Crystal structure of capsular polysaccharide synthesizing enzyme cape , k126e, in apo form (see paper)
36% identity, 82% coverage: 7:296/354 of query aligns to 3:284/318 of 3vvcA
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G12 (= G16), T14 (≠ A18), G15 (= G19), F17 (≠ V21), S37 (≠ D41), R38 (≠ N42), D39 (≠ N43), K42 (≠ E46), D61 (= D65), V62 (≠ I66), R63 (= R67), A81 (≠ T85), A82 (= A86), A83 (= A87), K85 (= K89), S124 (= S128), T125 (≠ S129), K139 (= K143), Y165 (≠ F169), G166 (= G170)
5bjuA X-ray structure of the pglf dehydratase from campylobacter jejuni in complex with udp and NAD(h) (see paper)
39% identity, 78% coverage: 3:279/354 of query aligns to 18:289/340 of 5bjuA
- binding nicotinamide-adenine-dinucleotide: G31 (= G16), G34 (= G19), T35 (= T20), I36 (≠ V21), D56 (= D41), H57 (≠ N42), S82 (≠ D65), I83 (= I66), A104 (≠ T85), A105 (= A86), A106 (= A87), K108 (= K89), N123 (≠ T104), I146 (≠ T127), K162 (= K143), F184 (= F169), G185 (= G170), N186 (= N171), V187 (= V172), S190 (= S175), S191 (≠ R176)
- binding uridine-5'-diphosphate: K150 (= K131), N186 (= N171), S193 (= S178), V194 (= V179), T209 (= T194), L210 (= L195), T211 (= T196), I215 (≠ M200), R217 (= R202), E279 (= E269)
5bjvA X-ray structure of the pglf udp-n-acetylglucosamine 4,6-dehydratase from campylobacterjejuni, d396n/k397a variant in complex with udp-n- acrtylglucosamine (see paper)
39% identity, 78% coverage: 3:279/354 of query aligns to 18:289/339 of 5bjvA
- binding nicotinamide-adenine-dinucleotide: G31 (= G16), G34 (= G19), T35 (= T20), I36 (≠ V21), D56 (= D41), H57 (≠ N42), S82 (≠ D65), I83 (= I66), A104 (≠ T85), A105 (= A86), A106 (= A87), K108 (= K89), N123 (≠ T104), I146 (≠ T127), K162 (= K143), F184 (= F169), G185 (= G170), N186 (= N171), V187 (= V172), S190 (= S175), S191 (≠ R176)
- binding uridine-diphosphate-n-acetylglucosamine: K108 (= K89), H109 (= H90), T148 (≠ S129), G185 (= G170), N186 (= N171), S193 (= S178), V194 (= V179), T209 (= T194), L210 (= L195), T211 (= T196), I215 (≠ M200), R217 (= R202), R276 (≠ K266), E279 (= E269)
3vvbA Crystal structure of capsular polysaccharide synthesizing enzyme cape from staphylococcus aureus in apo form (see paper)
31% identity, 70% coverage: 7:254/354 of query aligns to 1:225/270 of 3vvbA
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G10 (= G16), T12 (≠ A18), G13 (= G19), S14 (≠ T20), F15 (≠ V21), S35 (≠ D41), R36 (≠ N42), D37 (≠ N43), K40 (≠ E46), D59 (= D65), V60 (≠ I66), A80 (= A86), A81 (= A87), K83 (= K89), L121 (≠ T127), T123 (≠ S129), K137 (= K143), Y163 (≠ F169), G164 (= G170)
4tqgA Crystal structure of megavirus udp-glcnac 4,6-dehydratase, 5-epimerase mg534 (see paper)
28% identity, 93% coverage: 9:336/354 of query aligns to 5:295/297 of 4tqgA
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: G12 (= G16), S14 (≠ A18), G15 (= G19), S16 (≠ T20), L17 (≠ V21), R36 (≠ N42), D37 (≠ N43), D59 (= D65), I60 (= I66), A81 (≠ T85), A82 (= A86), A83 (= A87), K85 (= K89), V128 (≠ T127), Y140 (≠ M139), K144 (= K143), Y168 (≠ F169), G169 (= G170), V171 (= V172)
3pvzA Udp-n-acetylglucosamine 4,6-dehydratase from vibrio fischeri
27% identity, 69% coverage: 12:256/354 of query aligns to 33:281/372 of 3pvzA
- binding nicotinamide-adenine-dinucleotide: G40 (= G19), S41 (≠ T20), I42 (≠ V21), D62 (= D41), I63 (≠ N42), D92 (vs. gap), I93 (vs. gap), L114 (≠ T85), S115 (≠ A86), A116 (= A87), K118 (= K89), V158 (≠ T127), D161 (= D130), K174 (= K143), V198 (= V172), S201 (= S175)
3pvzB Udp-n-acetylglucosamine 4,6-dehydratase from vibrio fischeri
27% identity, 69% coverage: 12:257/354 of query aligns to 31:271/300 of 3pvzB
- binding nicotinamide-adenine-dinucleotide: G38 (= G19), S39 (≠ T20), I40 (≠ V21), D60 (= D41), I61 (≠ N42), L89 (vs. gap), D90 (vs. gap), I91 (vs. gap), L112 (≠ T85), S113 (≠ A86), A114 (= A87), K116 (= K89), D159 (= D130), K172 (= K143), N195 (= N171), V196 (= V172), S199 (= S175)
6dntA Udp-n-acetylglucosamine 4-epimerase from methanobrevibacter ruminantium m1 in complex with udp-n-acetylmuramic acid (see paper)
26% identity, 77% coverage: 8:278/354 of query aligns to 2:301/310 of 6dntA
- active site: S120 (= S129), S121 (≠ D130), A122 (≠ K131), Y144 (≠ L144), K148 (≠ R148), A187 (≠ S178)
- binding (2R)-2-{[(2R,3R,4R,5S,6R)-3-(acetylamino)-2-{[(S)-{[(R)-{[(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methoxy}(hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]oxy}-5-hydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-4-yl]oxy}propanoic acid: A80 (≠ K89), S120 (= S129), S121 (≠ D130), Y144 (≠ L144), F172 (≠ G170), N173 (= N171), A187 (≠ S178), V188 (= V179), K191 (≠ L182), V203 (= V193), I204 (≠ T194), Y205 (≠ L195), Q210 (≠ M200), R212 (= R202), I246 (= I236), R269 (≠ A254), D272 (= D257)
- binding nicotinamide-adenine-dinucleotide: G10 (= G16), G13 (= G19), F14 (≠ T20), I15 (≠ V21), D33 (= D41), N34 (= N42), L35 (≠ N43), S36 (≠ E44), S37 (= S45), G38 (≠ E46), D57 (= D65), L58 (≠ I66), L76 (≠ T85), A77 (= A86), A78 (= A87), A80 (≠ K89), S118 (≠ T127), S119 (= S128), Y144 (≠ L144), K148 (≠ R148), Y171 (≠ F169), V174 (= V172)
- binding zinc ion: E209 (≠ R199), H275 (vs. gap)
Q9LPG6 Trifunctional UDP-glucose 4,6-dehydratase/UDP-4-keto-6-deoxy-D-glucose 3,5-epimerase/UDP-4-keto-L-rhamnose-reductase RHM2; NDP-rhamnose synthase; Protein MUCILAGE-MODIFIED 4; Protein RHAMNOSE BIOSYNTHESIS 2; Rhamnose biosynthetic enzyme 2; AtRHM2; UDP-L-rhamnose synthase MUM4; EC 4.2.1.76; EC 1.1.1.-; EC 5.1.3.- from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
26% identity, 72% coverage: 7:262/354 of query aligns to 6:283/667 of Q9LPG6
- G18 (= G19) mutation to A: Abolishes dehydratase activity.
- K36 (≠ E36) mutation to A: Reduces dehydratase activity.
- D96 (≠ I92) mutation to N: In mum4-1; no extruded mucilage and seed coat defects. Abolishes dehydratase activity.
- K165 (= K143) mutation to A: Abolishes dehydratase activity.
- G193 (= G174) mutation to R: In mum4-2; no extruded mucilage and seed coat defects. Abolishes dehydratase activity.
Sites not aligning to the query:
- 392 G→A: No effect on dehydratase activity.
- 413 K→A: No effect on dehydratase activity.
- 518 K→A: No effect on dehydratase activity.
3ruhA Alternative analogs as viable substrates of udp-hexose 4-epimerases
32% identity, 34% coverage: 10:129/354 of query aligns to 17:142/336 of 3ruhA
- active site: S142 (= S129)
- binding nicotinamide-adenine-dinucleotide: G23 (= G16), G26 (= G19), F27 (≠ T20), I28 (≠ V21), D47 (≠ I30), N48 (= N31), S50 (≠ Q33), T51 (≠ P34), G52 (= G35), D78 (= D65), I79 (= I66), Q98 (≠ T85), A99 (= A86), A100 (= A87), T117 (= T104), A140 (≠ T127), A141 (≠ S128), S142 (= S129)
- binding [[(2R,3S,4R,5R)-5-[2,4-bis(oxidanylidene)pyrimidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl][(2R,3R,4R,5R,6R)-6-(hydroxymethyl)-4,5-bis(oxidanyl)-3-(2-oxidanylidenepropyl)oxan-2-yl] hydrogen phosphate: G102 (≠ K89), S103 (≠ H90), S142 (= S129)
Sites not aligning to the query:
- active site: 143, 144, 166, 170, 204
- binding nicotinamide-adenine-dinucleotide: 166, 170, 193, 196
- binding [[(2R,3S,4R,5R)-5-[2,4-bis(oxidanylidene)pyrimidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl][(2R,3R,4R,5R,6R)-6-(hydroxymethyl)-4,5-bis(oxidanyl)-3-(2-oxidanylidenepropyl)oxan-2-yl] hydrogen phosphate: 143, 144, 166, 193, 195, 209, 210, 213, 214, 225, 226, 227, 234, 271, 294, 297, 298, 301
Query Sequence
>WP_013707581.1 NCBI__GCF_000195295.1:WP_013707581.1
MNIADFYKNKNILITGAAGTVGRELIRQLINYQPGELRLMDNNESEMFFLMEEYRTSNIF
CFLGDIRDRDKIEKLAKDVDIIIHTAAFKHVILSEINPFDAVQTNIMGVQNIIKAASARK
VKYVLFTSSDKAVNPTNVMGTSKLMGERLITAANAFDSPRTAVFSSTRFGNVLGSRGSVV
PLFMKQIRQGGPVTLTDKRMTRFIMTVAESANLVLQSLTLARGGEVFVTKMPVARIPDLA
EVLIELLAPKYGYAPEDIKIIEIGIKPGEKLYEELMSEEEMHRSLELKDMFVVTPAFKSV
YQITFEYPDTISPQVRKPYASSGESALIKEAIKDYLVTNQVLEAVESGLYRGTI
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory