SitesBLAST
Comparing WP_013721235.1 NCBI__GCF_000204645.1:WP_013721235.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
5u9pB Crystal structure of a gluconate 5-dehydrogenase from burkholderia cenocepacia j2315 in complex with NADP and tartrate
39% identity, 97% coverage: 1:250/257 of query aligns to 5:255/261 of 5u9pB
- active site: G27 (= G23), S152 (= S148), Y165 (= Y161), K169 (= K165)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G23 (= G19), R26 (≠ S22), G27 (= G23), I28 (≠ L24), R48 (= R44), D73 (= D69), V74 (= V70), N100 (= N95), A101 (= A96), I150 (≠ V146), Y165 (= Y161), K169 (= K165), P195 (= P191), F198 (≠ V194), T200 (= T196), L202 (= L198), N203 (= N199)
4hp8B Crystal structure of a putative 2-deoxy-d-gluconate 3-dehydrogenase from agrobacterium tumefaciens (target efi-506435) with bound NADP
41% identity, 96% coverage: 8:253/257 of query aligns to 4:244/246 of 4hp8B
- active site: G19 (= G23), S138 (= S148), V148 (= V158), Y151 (= Y161), K155 (= K165)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G15 (= G19), N17 (≠ S21), T18 (≠ S22), G19 (= G23), L20 (= L24), R40 (= R44), R41 (= R45), D63 (= D69), F64 (≠ V70), N85 (= N95), G87 (= G97), I88 (≠ V98), I136 (≠ V146), Y151 (= Y161), K155 (= K165), P181 (= P191), G182 (= G192), I184 (≠ V194), T186 (= T196), N188 (≠ L198), T189 (≠ N199)
3osuA Crystal structure of the 3-oxoacyl-acyl carrier protein reductase, fabg, from staphylococcus aureus
39% identity, 93% coverage: 13:250/257 of query aligns to 5:242/246 of 3osuA
3sj7A Structure of beta-ketoacetyl-coa reductase (fabg) from staphylococcus aureus complex with NADPH (see paper)
39% identity, 93% coverage: 13:250/257 of query aligns to 2:235/239 of 3sj7A
- active site: G12 (= G23), S138 (= S148), Q148 (≠ V158), Y151 (= Y161), K155 (= K165)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: G8 (= G19), S10 (= S21), R11 (≠ S22), I13 (≠ L24), N31 (vs. gap), Y32 (≠ A42), A33 (= A43), G34 (≠ R44), S35 (≠ R45), A58 (≠ L68), N59 (≠ D69), V60 (= V70), N86 (= N95), A87 (= A96), T109 (= T118), S138 (= S148), Y151 (= Y161), K155 (= K165), P181 (= P191), G182 (= G192)
4za2D Crystal structure of pectobacterium carotovorum 2-keto-3-deoxy-d- gluconate dehydrogenase complexed with NAD+ (see paper)
35% identity, 97% coverage: 5:253/257 of query aligns to 3:245/247 of 4za2D
- binding nicotinamide-adenine-dinucleotide: G17 (= G19), D19 (≠ S21), L22 (= L24), I42 (≠ R45), D65 (= D69), M66 (≠ V70), N92 (= N95), A93 (= A96), G94 (= G97), L115 (≠ T118), I143 (≠ V146), S145 (= S148), Y158 (= Y161), K162 (= K165), G189 (= G192), M191 (≠ V194), T193 (= T196), N195 (≠ L203)
4jroC Crystal structure of 3-oxoacyl-[acyl-carrier protein]reductase (fabg) from listeria monocytogenes in complex with NADP+
37% identity, 96% coverage: 8:254/257 of query aligns to 1:247/247 of 4jroC
- active site: G16 (= G23), S142 (= S148), Q152 (≠ V158), Y155 (= Y161), K159 (= K165)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G12 (= G19), S14 (= S21), R15 (≠ S22), G16 (= G23), I17 (≠ L24), N35 (vs. gap), Y36 (vs. gap), N37 (vs. gap), G38 (vs. gap), S39 (vs. gap), N63 (≠ D69), V64 (= V70), N90 (= N95), A91 (= A96), I93 (≠ V98), I113 (≠ T118), S142 (= S148), Y155 (= Y161), K159 (= K165), P185 (= P191), I188 (≠ V194), T190 (= T196)
3uf0A Crystal structure of a putative NAD(p) dependent gluconate 5- dehydrogenase from beutenbergia cavernae(efi target efi-502044) with bound NADP (low occupancy)
43% identity, 96% coverage: 8:255/257 of query aligns to 3:249/249 of 3uf0A
- active site: G18 (= G23), S141 (= S148), V151 (= V158), Y154 (= Y161), K158 (= K165)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G14 (= G19), S17 (= S22), G18 (= G23), I19 (≠ L24), R39 (= R45), D63 (= D69), L64 (≠ V70), N89 (= N95), G91 (= G97), I92 (≠ V98), I139 (≠ V146), A140 (= A147), S141 (= S148), Y154 (= Y161), K158 (= K165), P184 (= P191), G185 (= G192), V187 (= V194), T189 (= T196), N191 (= N199), T192 (≠ R200)
7do7A Crystal structure of azotobacter vinelandii l-rhamnose 1- dehydrogenase(NAD and l-rhamnose bound-form) (see paper)
38% identity, 95% coverage: 13:255/257 of query aligns to 6:254/256 of 7do7A
- active site: G16 (= G23), S146 (= S148), Y159 (= Y161)
- binding nicotinamide-adenine-dinucleotide: G12 (= G19), R15 (≠ S22), G16 (= G23), I17 (≠ L24), S37 (≠ R44), D66 (= D69), A67 (≠ V70), N93 (= N95), A94 (= A96), G95 (= G97), I96 (≠ V98), V144 (= V146), S145 (≠ A147), S146 (= S148), Y159 (= Y161), K163 (= K165), P189 (= P191), G190 (= G192), I192 (≠ V194), T194 (= T196), I196 (≠ L198)
- binding beta-L-rhamnopyranose: F99 (≠ T101), S146 (= S148), S148 (≠ E152), Q156 (≠ P160), Y159 (= Y161), N197 (= N199), D235 (= D236), M236 (≠ A237), R238 (≠ A239)
7b81A Crystal structure of azotobacter vinelandii l-rhamnose 1-dehydrogenase (NAD bound-form) (see paper)
38% identity, 95% coverage: 13:255/257 of query aligns to 6:254/256 of 7b81A
- active site: G16 (= G23), S146 (= S148), Y159 (= Y161)
- binding nicotinamide-adenine-dinucleotide: G12 (= G19), S14 (= S21), R15 (≠ S22), I17 (≠ L24), D66 (= D69), A67 (≠ V70), N93 (= N95), A94 (= A96), G95 (= G97), I96 (≠ V98), T116 (= T118), V144 (= V146), S146 (= S148), Y159 (= Y161), K163 (= K165), P189 (= P191), G190 (= G192), I192 (≠ V194), T194 (= T196), I196 (≠ L198)
1vl8B Crystal structure of gluconate 5-dehydrogenase (tm0441) from thermotoga maritima at 2.07 a resolution
38% identity, 95% coverage: 8:250/257 of query aligns to 2:247/252 of 1vl8B
- active site: G17 (= G23), S143 (= S148), I154 (≠ V158), Y157 (= Y161), K161 (= K165)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G13 (= G19), R16 (≠ S22), G17 (= G23), L18 (= L24), S37 (≠ A43), R38 (= R44), C63 (≠ L68), D64 (= D69), V65 (= V70), A91 (≠ N95), A92 (= A96), G93 (= G97), I94 (≠ V98), V114 (≠ T118), I141 (≠ V146), S143 (= S148), Y157 (= Y161), K161 (= K165), P187 (= P191), G188 (= G192), Y190 (≠ V194), T192 (= T196), M194 (≠ L198), T195 (≠ N199)
P0AEK2 3-oxoacyl-[acyl-carrier-protein] reductase FabG; 3-ketoacyl-acyl carrier protein reductase; Beta-Ketoacyl-acyl carrier protein reductase; Beta-ketoacyl-ACP reductase; EC 1.1.1.100 from Escherichia coli (strain K12) (see 2 papers)
34% identity, 95% coverage: 8:250/257 of query aligns to 1:239/244 of P0AEK2
- GASR 12:15 (≠ GASS 19:22) binding NADP(+)
- T37 (≠ R44) binding NADP(+)
- NV 59:60 (≠ DV 69:70) binding NADP(+)
- N86 (= N95) binding NADP(+)
- Y151 (= Y161) mutation to F: Defect in the affinity for NADPH.
- YAAAK 151:155 (≠ YAISK 161:165) binding NADP(+)
- A154 (≠ S164) mutation to T: Decreases in the thermolability of the reductase; when associated with K-233.
- K155 (= K165) mutation to A: Defect in the affinity for NADPH.
- I184 (≠ V194) binding NADP(+)
- E233 (≠ A244) mutation to K: Decreases in the thermolability of the reductase; when associated with T-154.
1q7bA The structure of betaketoacyl-[acp] reductase from e. Coli in complex with NADP+ (see paper)
34% identity, 94% coverage: 9:250/257 of query aligns to 1:238/243 of 1q7bA
- active site: G15 (= G23), E101 (≠ D111), S137 (= S148), Q147 (≠ V158), Y150 (= Y161), K154 (= K165)
- binding calcium ion: E232 (≠ A244), T233 (= T245)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G11 (= G19), S13 (= S21), R14 (≠ S22), T36 (≠ R44), N58 (≠ D69), V59 (= V70), N85 (= N95), A86 (= A96), G87 (= G97), I88 (≠ V98), S137 (= S148), Y150 (= Y161), K154 (= K165), P180 (= P191), G181 (= G192), I183 (≠ V194)
3o03A Quaternary complex structure of gluconate 5-dehydrogenase from streptococcus suis type 2 (see paper)
35% identity, 97% coverage: 4:253/257 of query aligns to 3:247/254 of 3o03A
- active site: G22 (= G23), S147 (= S148), V157 (= V158), Y160 (= Y161), K164 (= K165)
- binding calcium ion: S147 (= S148), M148 (≠ I149), P190 (= P191)
- binding D-gluconic acid: I99 (≠ T99), R101 (≠ T101), S147 (= S148), M149 (≠ L150), R154 (≠ A155), Y160 (= Y161)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G18 (= G19), Y21 (≠ S22), G22 (= G23), I23 (≠ L24), D42 (= D47), I43 (≠ K48), L47 (≠ V52), D68 (= D69), V69 (= V70), N95 (= N95), A96 (= A96), G97 (= G97), I145 (≠ V146), Y160 (= Y161), K164 (= K165), P190 (= P191)
P08074 Carbonyl reductase [NADPH] 2; Adipocyte protein P27; AP27; Lung carbonyl reductase; LCR; NADPH-dependent carbonyl reductase 2; EC 1.1.1.184 from Mus musculus (Mouse) (see 2 papers)
35% identity, 97% coverage: 7:255/257 of query aligns to 2:244/244 of P08074
- 11:39 (vs. 16:44, 45% identical) binding NADP(+)
- T38 (≠ A43) mutation to R: Converts the coenzyme specificity from NADP to NAD.
4cqlI Crystal structure of heterotetrameric human ketoacyl reductase complexed with NAD (see paper)
36% identity, 94% coverage: 10:250/257 of query aligns to 6:247/251 of 4cqlI
- active site: G19 (= G23), S146 (= S148), Y159 (= Y161), K163 (= K165)
- binding nicotinamide-adenine-dinucleotide: S18 (= S22), G19 (= G23), I20 (≠ L24), D39 (≠ A43), L40 (≠ R44), A64 (≠ L68), D65 (= D69), V66 (= V70), C93 (≠ N95), A94 (= A96), G95 (= G97), I96 (≠ V98), V116 (≠ T118), I144 (≠ V146), S146 (= S148), Y159 (= Y161), K163 (= K165), P189 (= P191), G190 (= G192), I192 (≠ V194), T194 (= T196), M196 (≠ L198)
1q7cA The structure of betaketoacyl-[acp] reductase y151f mutant in complex with NADPH fragment (see paper)
34% identity, 94% coverage: 9:250/257 of query aligns to 1:238/243 of 1q7cA
- active site: G15 (= G23), S137 (= S148), Q147 (≠ V158), F150 (≠ Y161), K154 (= K165)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: G11 (= G19), S13 (= S21), R14 (≠ S22), A35 (= A43), T36 (≠ R44), L57 (= L68), N58 (≠ D69), V59 (= V70), G87 (= G97), I88 (≠ V98)
1cydA Carbonyl reductase complexed with NADPH and 2-propanol (see paper)
35% identity, 96% coverage: 8:255/257 of query aligns to 1:242/242 of 1cydA
- active site: G16 (= G23), S134 (= S148), L144 (≠ V158), Y147 (= Y161), K151 (= K165)
- binding isopropyl alcohol: S134 (= S148), Y147 (= Y161), V188 (≠ F202)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: G12 (= G19), G14 (≠ S21), K15 (≠ S22), I17 (≠ L24), R37 (= R44), T38 (≠ R45), D58 (= D69), L59 (≠ V70), N81 (= N95), A83 (≠ G97), V104 (≠ T118), V132 (= V146), S134 (= S148), Y147 (= Y161), K151 (= K165), P177 (= P191), T178 (≠ G192), V179 (≠ Y193), V180 (= V194), T182 (= T196), M184 (≠ L198), G185 (≠ N199)
4cqmA Crystal structure of heterotetrameric human ketoacyl reductase complexed with NAD and NADP (see paper)
37% identity, 94% coverage: 10:250/257 of query aligns to 4:244/248 of 4cqmA
- active site: G17 (= G23), S143 (= S148), Y156 (= Y161), K160 (= K165)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G13 (= G19), S16 (= S22), G17 (= G23), I18 (≠ L24), D37 (≠ A43), L38 (≠ R44), A61 (≠ L68), V63 (= V70), C90 (≠ N95), A91 (= A96), G92 (= G97), I93 (≠ V98), V113 (≠ T118), I141 (≠ V146), S143 (= S148), Y156 (= Y161), K160 (= K165), P186 (= P191), G187 (= G192), I189 (≠ V194), T191 (= T196), P192 (≠ D197), M193 (≠ L198), T194 (≠ N199)
7do6A Crystal structure of azotobacter vinelandii l-rhamnose 1- dehydrogenase(NADP bound-form) (see paper)
37% identity, 95% coverage: 13:255/257 of query aligns to 6:245/247 of 7do6A
- active site: G16 (= G23), S146 (= S148), Y159 (= Y161)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G12 (= G19), S14 (= S21), R15 (≠ S22), G16 (= G23), I17 (≠ L24), H36 (≠ A43), S37 (≠ R44), G42 (≠ L49), D66 (= D69), A67 (≠ V70), N93 (= N95), A94 (= A96), G95 (= G97), I96 (≠ V98), T116 (= T118), S146 (= S148), Y159 (= Y161), K163 (= K165), I192 (≠ V195)
4i08A Crystal structure of beta-ketoacyl-acyl carrier protein reductase (fabg) from vibrio cholerae in complex with NADPH (see paper)
34% identity, 95% coverage: 8:250/257 of query aligns to 4:238/243 of 4i08A
- active site: G19 (= G23), N113 (= N119), S141 (= S148), Q151 (≠ V158), Y154 (= Y161), K158 (= K165)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: G15 (= G19), S17 (= S21), R18 (≠ S22), I20 (≠ L24), T40 (≠ R44), N62 (≠ D69), V63 (= V70), N89 (= N95), A90 (= A96), G140 (≠ A147), S141 (= S148), Y154 (= Y161), K158 (= K165), P184 (= P191), G185 (= G192), T189 (= T196)
Query Sequence
>WP_013721235.1 NCBI__GCF_000204645.1:WP_013721235.1
MTAAMDRFSLRGRLALVTGASSGLGTHFAQVLAAAGARVAVAARRVDKLQCVVDAIAAEG
GEARAFALDVADSASVRACFDALCAWGVPDVVVNNAGVTVTRPALEQTEEDFDHVLGTNL
KGNWLVATEAARRMVAAGKGGAIVNVASILGERVAGGVAPYAISKAGVVQATKALALELA
RHGIRVNALLPGYVVTDLNRGFLTSPAGEKLRARIPSRRFGEVTDLDGPLLLLASDAGAA
MSGATLAVDGAHLVSSL
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory