SitesBLAST

P07464 Galactoside O-acetyltransferase; GAT; Acetyl-CoA:galactoside 6-O-acetyltransferase; Thiogalactoside acetyltransferase; Thiogalactoside transacetylase; EC 2.3.1.18 from Escherichia coli (strain K12) (see 3 papers)
44% identity, 40% coverage: 68:130/157 of query aligns to 119:184/203 of P07464

query
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P07464

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S142 (≠ A88) binding in other chain
A160 (= A106) binding in other chain
TK 165:166 (≠ TR 111:112) binding acetyl-CoA
R180 (≠ K126) binding acetyl-CoA
R183 (= R129) binding in other chain

Sites not aligning to the query:

1 modified: Initiator methionine, Removed; Partial
17 binding substrate
71 binding substrate
85 binding in other chain; binding in other chain
93 binding substrate
115 H→A: Results in an 1800-fold decrease in catalytic activity.

1krvA Galactoside acetyltransferase in complex with coa and pnp-beta-gal (see paper)
44% identity, 40% coverage: 68:130/157 of query aligns to 118:183/201 of 1krvA

query
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1krvA

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binding 4-nitrophenyl beta-D-galactopyranoside: M126 (≠ L76)
binding coenzyme a: W138 (≠ F85), G140 (= G87), S141 (≠ A88), N146 (≠ M93), A159 (= A106), P177 (= P124), R179 (≠ K126), R182 (= R129)

Sites not aligning to the query:

binding 4-nitrophenyl beta-D-galactopyranoside: 16, 25, 70, 82, 84, 90, 92
binding coenzyme a: 104, 110, 112

1kruA Galactoside acetyltransferase in complex with iptg and coenzyme a (see paper)
44% identity, 40% coverage: 68:130/157 of query aligns to 118:183/201 of 1kruA

query
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1kruA

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binding coenzyme a: W138 (≠ F85), G140 (= G87), S141 (≠ A88), G158 (= G105), A159 (= A106), P177 (= P124), R182 (= R129)
binding 1-methylethyl 1-thio-beta-D-galactopyranoside: M126 (≠ L76)

Sites not aligning to the query:

binding coenzyme a: 114
binding 1-methylethyl 1-thio-beta-D-galactopyranoside: 16, 22, 25, 62, 70, 82, 82, 84, 90, 92, 102, 114

4n6bA Soybean serine acetyltransferase complexed with coa (see paper)
38% identity, 66% coverage: 26:128/157 of query aligns to 131:233/233 of 4n6bA

query
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4n6bA

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binding coenzyme a: H150 (≠ K45), L169 (= L66), G176 (= G73), K208 (≠ I103), G210 (= G105), A211 (= A106), L216 (≠ T111), V226 (≠ A121)

4isxA The crystal structure of maltose o-acetyltransferase from clostridium difficile 630 in complex with acetyl-coa
43% identity, 47% coverage: 57:130/157 of query aligns to 112:183/186 of 4isxA

query
sites
4isxA

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binding acetyl coenzyme *a: W138 (≠ F85), G140 (= G87), G141 (≠ A88), A159 (= A106), V174 (≠ A121), K182 (≠ R129)

Sites not aligning to the query:

binding acetyl coenzyme *a: 84, 104

4n69A Soybean serine acetyltransferase complexed with serine (see paper)
37% identity, 66% coverage: 26:128/157 of query aligns to 138:243/243 of 4n69A

query
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4n69A

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binding serine: G183 (= G73), R191 (≠ L76), H192 (= H77)

3igjC Crystal structure of maltose o-acetyltransferase complexed with acetyl coenzyme a from bacillus anthracis
55% identity, 32% coverage: 79:129/157 of query aligns to 134:184/188 of 3igjC

query
sites
3igjC

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binding acetyl coenzyme *a: G142 (= G87), N148 (≠ M93), A160 (≠ G105), S161 (≠ A106), T166 (= T111), N178 (= N123)

Sites not aligning to the query:

binding acetyl coenzyme *a: 84, 106, 112, 114, 116

5u2kA Crystal structure of galactoside o-acetyltransferase complex with coa (h3 space group)
44% identity, 33% coverage: 79:130/157 of query aligns to 132:183/190 of 5u2kA

query
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5u2kA

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binding coenzyme a: L146 (≠ M93), T164 (= T111), K165 (≠ R112)

Sites not aligning to the query:

binding coenzyme a: 90, 110, 112, 114

4mzuF Crystal structure of fdtd, a bifunctional ketoisomerase/n- acetyltransferase from shewanella denitrificans (see paper)
42% identity, 50% coverage: 50:127/157 of query aligns to 64:140/294 of 4mzuF

query
sites
4mzuF

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binding coenzyme a: N81 (≠ H68), D82 (= D69), K83 (≠ L70), G100 (= G87), A101 (= A88), L106 (≠ M93), G118 (= G105), A119 (= A106), T124 (= T111), K125 (≠ R112), I134 (≠ A121), N136 (= N123), R139 (≠ K126)

Sites not aligning to the query:

binding thymine: 20, 21, 38
binding thymidine-5'-diphosphate: 189, 203, 205, 270

8j40A Crystal structure of catb8 in complex with chloramphenicol (see paper)
51% identity, 34% coverage: 78:130/157 of query aligns to 110:162/209 of 8j40A

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8j40A

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binding chloramphenicol: W117 (≠ F85), V135 (≠ I103), S138 (≠ A106)

Sites not aligning to the query:

binding chloramphenicol: 7, 8, 9, 29, 31, 47, 50, 90, 187, 190, 191, 202, 203, 206

4mzuB Crystal structure of fdtd, a bifunctional ketoisomerase/n- acetyltransferase from shewanella denitrificans (see paper)
42% identity, 50% coverage: 50:127/157 of query aligns to 64:139/290 of 4mzuB

query
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4mzuB

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binding coenzyme a: F72 (≠ Y58), T80 (≠ L66), N81 (≠ T67), D82 (≠ H68), K83 (≠ D69), P85 (≠ T71), G99 (= G87), A100 (= A88), G117 (= G105), A118 (= A106), T123 (= T111), K124 (≠ R112), I133 (≠ A121), R138 (≠ K126)
binding magnesium ion: N76 (≠ D62)

Sites not aligning to the query:

binding coenzyme a: 199
binding magnesium ion: 58
binding thymine: 20, 21, 38, 39
binding thymidine-5'-diphosphate: 171, 176, 189, 191, 202, 203, 270

A1ADJ6 Polysialic acid O-acetyltransferase; Capsule O-acetyl transferase; EC 2.3.1.136 from Escherichia coli O1:K1 / APEC (see paper)
37% identity, 43% coverage: 85:151/157 of query aligns to 234:300/307 of A1ADJ6

query
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A1ADJ6

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W234 (≠ F85) mutation to A: Loss of activity.

Sites not aligning to the query:

210 H→A: Loss of activity.

6wyeA Crystal structure of neisseria gonorrhoeae serine acetyltransferase (cyse) (see paper)
32% identity, 78% coverage: 12:134/157 of query aligns to 126:251/261 of 6wyeA

query
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6wyeA

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G

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N

V

P

P

A

A

K

K

I

P

I

V

R

A

E

R

N

S

V

L

Q

K

T

T

binding (2S)-2-hydroxybutanedioic acid: D158 (= D44), H159 (≠ K45), G185 (vs. gap), R193 (≠ L76), H194 (= H77)

Sites not aligning to the query:

binding (2S)-2-hydroxybutanedioic acid: 93, 94

3fsbA Crystal structure of qdtc, the dtdp-3-amino-3,6-dideoxy-d-glucose n- acetyl transferase from thermoanaerobacterium thermosaccharolyticum in complex with coa and dtdp-3-amino-quinovose (see paper)
42% identity, 50% coverage: 51:128/157 of query aligns to 135:219/260 of 3fsbA

query
sites
3fsbA

I

V

H

F

L

V

G

G

E

E

Y

K

S

S

Y

I

V

I

A

K

-

D

-

F

-

V

-

W

-

L

F
|
F

D

P

A

H

A

V

I

V

L

L

T

T

H

N

D

D

L

P

T

T

-

P

R

S

G

N

V

E

R

L

L

L

H

G

T

V

R

T

I

I

G

E

K

L

N

F

C

A

F

V

I

I

G
x
A

A
|
A

R

R

S

S

I

V

M

L

P

P

G

G

I

I

N

H

I

I

G

N

D

E

G

D

A

A

I

L

V

V

G
|
G

A
|
A

G

G

A

A

V

V

T

T

R

K

D

D

V

V

P

P

A

K

N

E

A

T

V

V

A

V

A
x
V

G

G

N

N

P

P

A

A

K

R

I

E

I

I

binding coenzyme a: F150 (= F61), A178 (≠ G87), A179 (= A88), G196 (= G105), A197 (= A106), V212 (≠ A121)
binding [(3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl][hydroxy-[[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy]phosphoryl] hydrogen phosphate: F150 (= F61)

Sites not aligning to the query:

binding [(3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl][hydroxy-[[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy]phosphoryl] hydrogen phosphate: 78, 114, 132, 241, 243

8vr6A Crystal structure of the pcryo_0619 n-acetryltransferase from psychrobacter cryohalolentis k5 in the presence of coa-disulfide
36% identity, 46% coverage: 65:136/157 of query aligns to 96:176/177 of 8vr6A

query
sites
8vr6A

I

I

L
x
Y

T

T

H
|
H

D
|
D

L
x
T

T

V

R

R

G

K

V

S

-

L

-

S

-

G

-

K

-

A

-

D

-

I

-

D

R

K

L

A

H

S

T

T

R

R

I

I

G

G

K

S

N

D

C

C

F

Y

I

L

G

G

A

P

R

N

S

T

I

I

M
x
V

P

K

G

G

I

V

N

K

I

I

G

G

D

D

G

R

A

V

I

V

V

V

G

G

A

A

G

N

A

S

V
x
L

V

V

T
x
L

R

K

D

D

V

I

P

P

A

S

N

D

A

C

V

K

A

V

A

F

G

G

N
x
S

P
|
P

A

A

K

V

I

I

R

T

E

D

N

S

V

L

Q

N

T

Y

G

Q

R

R

binding [[(2~{S},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(3~{R})-4-[[3-[2-[2-[3-[[(2~{R})-4-[[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-3,3-dimethyl-2-oxidanyl-butanoyl]amino]propanoylamino]ethyldisulfanyl]ethylamino]-3-oxidanylidene-propyl]amino]-2,2-dimethyl-3-oxidanyl-4-oxidanylidene-butyl] hydrogen phosphate: Y97 (≠ L66), H99 (= H68), D100 (= D69), T101 (≠ L70), V133 (≠ M93), L149 (≠ V109), L151 (≠ T111), S163 (≠ N123), P164 (= P124)

3fscA Crystal structure of qdtc, the dtdp-3-amino-3,6-dideoxy-d-glucose n- acetyl transferase from thermoanaerobacterium thermosaccharolyticum in complex with coa and dtdp-3-amino-fucose (see paper)
42% identity, 50% coverage: 51:128/157 of query aligns to 135:219/259 of 3fscA

query
sites
3fscA

I

V

H

F

L

V

G

G

E

E

Y

K

S

S

Y

I

V

I

A

K

-

D

-

F

-

V

-

W

-

L

F
|
F

D

P

A

H

A

V

I

V

L

L

T

T

H

N

D

D

L

P

T

T

-

P

R

S

G

N

V

E

R

L

L

L

H

G

T

V

R

T

I

I

G

E

K

L

N

F

C

A

F

V

I

I

G
x
A

A
|
A

R

R

S

S

I

V

M

L

P

P

G

G

I

I

N

H

I

I

G

N

D

E

G

D

A

A

I

L

V

V

G
|
G

A
|
A

G

G

A

A

V

V

T

T

R

K

D

D

V

V

P

P

A

K

N

E

A

T

V

V

A

V

A
x
V

G

G

N

N

P

P

A

A

K

R

I

E

I

I

binding coenzyme a: F150 (= F61), A178 (≠ G87), A179 (= A88), G196 (= G105), A197 (= A106), V212 (≠ A121)

Sites not aligning to the query:

3fs8A Crystal structure of qdtc, the dtdp-3-amino-3,6-dideoxy-d-glucose n- acetyl transferase from thermoanaerobacterium thermosaccharolyticum in complex with acetyl-coa (see paper)
42% identity, 50% coverage: 51:128/157 of query aligns to 135:219/259 of 3fs8A

query
sites
3fs8A

I

V

H

F

L

V

G

G

E

E

Y

K

S

S

Y

I

V

I

A

K

-

D

-

F

-

V

-

W

-

L

F
|
F

D
x
P

A

H

A

V

I

V

L

L

T

T

H

N

D

D

L

P

T

T

-

P

R

S

G

N

V

E

R

L

L

L

H

G

T

V

R

T

I

I

G

E

K

L

N

F

C

A

F

V

I

I

G
x
A

A
|
A

R

R

S

S

I

V

M

L

P

P

G

G

I

I

N

H

I

I

G

N

D

E

G

D

A

A

I

L

V

V

G
|
G

A
|
A

G

G

A

A

V

V

T

T

R

K

D

D

V

V

P

P

A

K

N

E

A

T

V

V

A

V

A
x
V

G

G

N

N

P

P

A

A

K

R

I

E

I

I

binding acetyl coenzyme *a: F150 (= F61), P151 (≠ D62), A178 (≠ G87), A179 (= A88), G196 (= G105), A197 (= A106), V212 (≠ A121)

Sites not aligning to the query:

8vr7B Crystal structure of the pcryo_0619 n-acetyltransferase from psychrobacter cryohalolentis k5 int he presence of acetyl coenzyme a
36% identity, 46% coverage: 65:136/157 of query aligns to 97:177/177 of 8vr7B

query
sites
8vr7B

I

I

L
x
Y

T

T

H

H

D
|
D

L
x
T

T

V

R

R

G

K

V

S

-

L

-

S

-

G

-

K

-

A

-

D

-

I

-

D

R

K

L

A

H

S

T

T

R
|
R

I

I

G

G

K

S

N

D

C

C

F
x
Y

I

L

G

G

A
x
P

R

N

S

T

I

I

M

V

P

K

G

G

I

V

N

K

I

I

G

G

D

D

G

R

A

V

I

V

V

V

G
|
G

A
|
A

G

N

A

S

V
x
L

V

V

T
x
L

R

K

D

D

V

I

P

P

A

S

N

D

A

C

V
x
K

A

V

A
x
F

G

G

N

S

P
|
P

A

A

K

V

I

I

R

T

E

D

N

S

V

L

Q

N

T
x
Y

G

Q

R

R

binding acetyl coenzyme *a: Y98 (≠ L66), D101 (= D69), T102 (≠ L70), L150 (≠ V109), L152 (≠ T111), P165 (= P124)
binding coenzyme a: Y126 (≠ F85), P129 (≠ A88), G146 (= G105), A147 (= A106), K160 (≠ V119), F162 (≠ A121), Y175 (≠ T134)
binding 3'-phosphate-adenosine-5'-diphosphate: R120 (= R79)

Sites not aligning to the query:

8vr7E Crystal structure of the pcryo_0619 n-acetyltransferase from psychrobacter cryohalolentis k5 int he presence of acetyl coenzyme a
36% identity, 46% coverage: 65:136/157 of query aligns to 97:177/180 of 8vr7E

query
sites
8vr7E

I

I

L
x
Y

T

T

H

H

D
|
D

L
x
T

T

V

R

R

G

K

V

S

-

L

-

S

-

G

-

K

-

A

-

D

-

I

-

D

R

K

L

A

H

S

T

T

R

R

I

I

G

G

K

S

N

D

C

C

F
x
Y

I

L

G

G

A

P

R

N

S

T

I

I

M
x
V

P

K

G

G

I

V

N

K

I

I

G

G

D

D

G

R

A

V

I

V

V

V

G
|
G

A
|
A

G

N

A

S

V
x
L

V

V

T
x
L

R

K

D

D

V

I

P

P

A

S

N

D

A

C

V
x
K

A

V

A
x
F

G

G

N
x
S

P
|
P

A

A

K

V

I

I

R

T

E

D

N

S

V

L

Q

N

T
x
Y

G

Q

R

R

binding acetyl coenzyme *a: Y98 (≠ L66), D101 (= D69), T102 (≠ L70), Y126 (≠ F85), V134 (≠ M93), G146 (= G105), A147 (= A106), L150 (≠ V109), L152 (≠ T111), K160 (≠ V119), F162 (≠ A121), S164 (≠ N123), P165 (= P124), Y175 (≠ T134)

Sites not aligning to the query:

Query Sequence

>WP_013818525.1 NCBI__GCF_000214665.1:WP_013818525.1
MAFRYAQLSFLRNLLVYIQKTVYRRIFRMDIHPTCNFSLSAKFDKTNPRGIHLGEYSYVA
FDAAILTHDLTRGVRLHTRIGKNCFIGARSIIMPGINIGDGAIVGAGAVVTRDVPANAVA
AGNPAKIIRENVQTGRYGRLQGADETQRLHTSLNNLD

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory