SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing WP_013834808.1 NCBI__GCF_000214825.1:WP_013834808.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

8et4A Crystal structure of wild-type arabidopsis thaliana acetohydroxyacid synthase in complex with amidosulfuron (see paper)
44% identity, 99% coverage: 5:563/565 of query aligns to 14:576/582 of 8et4A

query
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8et4A

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binding 2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-2-[(1~{S})-1-(dioxidanyl)-1-oxidanyl-ethyl]-4-methyl-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate: V400 (= V393), G401 (= G394), Q402 (= Q395), H403 (= H396), G426 (= G419), M428 (= M421), G452 (= G445), D453 (≠ E446), G454 (= G447), S455 (= S448), M458 (= M451), N480 (= N473), H482 (≠ Y475), L483 (= L476), G484 (= G477), M485 (= M478), V486 (= V479)
binding flavin-adenine dinucleotide: R161 (= R153), G222 (= G212), G223 (= G213), G224 (= G214), T246 (= T238), L247 (= L239), M248 (= M240), L264 (= L256), M266 (= M258), H267 (= H259), G286 (= G278), V287 (≠ S279), R288 (= R280), D290 (= D282), R292 (= R284), V293 (= V285), D310 (= D302), I311 (= I303), D329 (≠ P321), V330 (= V322), M405 (= M398), G423 (= G416)
binding magnesium ion: F370 (= F363), D453 (≠ E446), M458 (= M451), Q461 (= Q454), N480 (= N473), H482 (≠ Y475), K533 (≠ P519)
binding N-{[(4,6-dimethoxypyrimidin-2-yl)carbamoyl]sulfamoyl}-N-methylmethanesulfonamide: M266 (= M258), R292 (= R284), M485 (= M478), W489 (= W482), S568 (≠ A555)

5wj1A Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a triazolopyrimidine herbicide, penoxsulam (see paper)
44% identity, 99% coverage: 5:563/565 of query aligns to 14:576/582 of 5wj1A

query
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5wj1A

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active site: Y33 (= Y24), G35 (= G26), G36 (= G27), A37 (= A28), S38 (≠ A29), E59 (= E51), T82 (= T74), F121 (= F113), Q122 (= Q114), E123 (= E115), K171 (= K163), M266 (= M258), V293 (= V285), V400 (= V393), G426 (= G419), M428 (= M421), D453 (≠ E446), N480 (= N473), H482 (≠ Y475), L483 (= L476), M485 (= M478), V486 (= V479), W489 (= W482), H558 (≠ P545)
binding flavin-adenine dinucleotide: R161 (= R153), G222 (= G212), G223 (= G213), G224 (= G214), T246 (= T238), L247 (= L239), M248 (= M240), M263 (= M255), L264 (= L256), G286 (= G278), R288 (= R280), V293 (= V285), D310 (= D302), I311 (= I303), D329 (≠ P321), V330 (= V322), M405 (= M398), G423 (= G416), G424 (= G417)
binding magnesium ion: D453 (≠ E446), N480 (= N473), H482 (≠ Y475)
binding 2-(2,2-difluoroethoxy)-N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)-6-(trifluoromethyl)benzenesulfonamide: M266 (= M258), D291 (= D283), R292 (= R284), M485 (= M478), W489 (= W482), S568 (≠ A555)
binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V400 (= V393), G401 (= G394), Q402 (= Q395), H403 (= H396), M428 (= M421), D453 (≠ E446), G454 (= G447), S455 (= S448), M458 (= M451), N480 (= N473), H482 (≠ Y475), L483 (= L476), G484 (= G477), M485 (= M478), V486 (= V479)

5k6tA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylamino-carbonyl-triazolinone herbicide, propoxycarbazone-sodium (see paper)
44% identity, 99% coverage: 5:563/565 of query aligns to 14:576/582 of 5k6tA

query
sites
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active site: Y33 (= Y24), G35 (= G26), G36 (= G27), A37 (= A28), S38 (≠ A29), E59 (= E51), T82 (= T74), F121 (= F113), Q122 (= Q114), E123 (= E115), K171 (= K163), M266 (= M258), V293 (= V285), V400 (= V393), G426 (= G419), M428 (= M421), D453 (≠ E446), N480 (= N473), H482 (≠ Y475), L483 (= L476), M485 (= M478), V486 (= V479), W489 (= W482), H558 (≠ P545)
binding methyl 2-[(4-methyl-5-oxidanylidene-3-propoxy-1,2,4-triazol-1-yl)carbonylsulfamoyl]benzoate: H267 (= H259), R292 (= R284), M485 (= M478), W489 (= W482), S568 (≠ A555)
binding flavin-adenine dinucleotide: R161 (= R153), G222 (= G212), G223 (= G213), G224 (= G214), T246 (= T238), L247 (= L239), M248 (= M240), L264 (= L256), G286 (= G278), R288 (= R280), D290 (= D282), R292 (= R284), V293 (= V285), D310 (= D302), I311 (= I303), D329 (≠ P321), V330 (= V322), Q404 (= Q397), M405 (= M398), G423 (= G416)
binding magnesium ion: D453 (≠ E446), N480 (= N473), H482 (≠ Y475)
binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V400 (= V393), G401 (= G394), Q402 (= Q395), H403 (= H396), G426 (= G419), M428 (= M421), G452 (= G445), G454 (= G447), S455 (= S448), N480 (= N473), H482 (≠ Y475), L483 (= L476), G484 (= G477)

5k6rA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylamino-carbonyl-triazolinone herbicide, thiencarbazone-methyl (see paper)
44% identity, 99% coverage: 5:563/565 of query aligns to 14:576/582 of 5k6rA

query
sites
5k6rA

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P

K

K

A

T

D

M

L

R

R

Q

E

Q

A

L

I

E

Q

E

T

A

M

F

L

A

D

L

T

K

P

D

G

R

P

L

Y

V

L

F

-

I

L

D

D

I

V

L

I

T

C

D

P

P
x
H

Q

Q

E

E

N

H

V

V

Y

L

P

P

M

M

I

I

P

P

A
x
S

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G

A

G

G

T

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F

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N

E

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I

active site: Y33 (= Y24), G35 (= G26), G36 (= G27), A37 (= A28), S38 (≠ A29), E59 (= E51), T82 (= T74), F121 (= F113), Q122 (= Q114), E123 (= E115), K171 (= K163), M266 (= M258), V293 (= V285), V400 (= V393), G426 (= G419), M428 (= M421), D453 (≠ E446), N480 (= N473), H482 (≠ Y475), L483 (= L476), M485 (= M478), V486 (= V479), W489 (= W482), H558 (≠ P545)
binding methyl 4-[(3-methoxy-4-methyl-5-oxidanylidene-1,2,4-triazol-1-yl)carbonylsulfamoyl]-5-methyl-thiophene-3-carboxylate: R292 (= R284), W489 (= W482), S568 (≠ A555)
binding flavin-adenine dinucleotide: R161 (= R153), G222 (= G212), G223 (= G213), G224 (= G214), T246 (= T238), L247 (= L239), M248 (= M240), L264 (= L256), M266 (= M258), G286 (= G278), R288 (= R280), R292 (= R284), V293 (= V285), D310 (= D302), I311 (= I303), G328 (= G320), D329 (≠ P321), V330 (= V322), M405 (= M398), G423 (= G416)
binding magnesium ion: D453 (≠ E446), N480 (= N473), H482 (≠ Y475)
binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V400 (= V393), G401 (= G394), Q402 (= Q395), H403 (= H396), G426 (= G419), M428 (= M421), D453 (≠ E446), G454 (= G447), S455 (= S448), M458 (= M451), N480 (= N473), H482 (≠ Y475), L483 (= L476), G484 (= G477), M485 (= M478), V486 (= V479)

1z8nA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with an imidazolinone herbicide, imazaquin (see paper)
44% identity, 99% coverage: 5:563/565 of query aligns to 14:576/582 of 1z8nA

query
sites
1z8nA

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S

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Y

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F

-

I

L

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L

I

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x
H

Q

Q

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E

N

H

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L

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M

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I

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I

active site: Y33 (= Y24), G35 (= G26), G36 (= G27), A37 (= A28), S38 (≠ A29), E59 (= E51), T82 (= T74), F121 (= F113), Q122 (= Q114), E123 (= E115), K171 (= K163), M266 (= M258), V293 (= V285), V400 (= V393), G426 (= G419), M428 (= M421), D453 (≠ E446), N480 (= N473), H482 (≠ Y475), L483 (= L476), M485 (= M478), V486 (= V479), W489 (= W482), H558 (≠ P545)
binding 2-(4-isopropyl-4-methyl-5-oxo-4,5-dihydro-1h-imidazol-2-yl)quinoline-3-carboxylic acid: K135 (= K127), R161 (= R153), Y191 (= Y183), R194 (vs. gap), D291 (= D283), R292 (= R284), D312 (= D304), W489 (= W482), G569 (= G556)
binding flavin-adenine dinucleotide: R161 (= R153), G222 (= G212), G224 (= G214), T246 (= T238), L247 (= L239), M248 (= M240), L264 (= L256), G265 (= G257), M266 (= M258), H267 (= H259), G286 (= G278), V287 (≠ S279), R288 (= R280), D290 (= D282), R292 (= R284), V293 (= V285), D310 (= D302), I311 (= I303), D329 (≠ P321), V330 (= V322), M405 (= M398), G423 (= G416), G424 (= G417)
binding magnesium ion: D453 (≠ E446), N480 (= N473)
binding thiamine diphosphate: V400 (= V393), G401 (= G394), Q402 (= Q395), H403 (= H396), G426 (= G419), M428 (= M421), G452 (= G445), G454 (= G447), S455 (= S448), N480 (= N473), H482 (≠ Y475), L483 (= L476), G484 (= G477), M485 (= M478), V486 (= V479)

1yi1A Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, tribenuron methyl (see paper)
44% identity, 99% coverage: 5:563/565 of query aligns to 14:576/582 of 1yi1A

query
sites
1yi1A

G

G

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A

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x
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active site: Y33 (= Y24), G35 (= G26), G36 (= G27), A37 (= A28), S38 (≠ A29), E59 (= E51), T82 (= T74), F121 (= F113), Q122 (= Q114), E123 (= E115), K171 (= K163), M266 (= M258), V293 (= V285), V400 (= V393), G426 (= G419), M428 (= M421), D453 (≠ E446), N480 (= N473), H482 (≠ Y475), L483 (= L476), M485 (= M478), V486 (= V479), W489 (= W482), H558 (≠ P545)
binding methyl 2-[4-methoxy-6-methyl-1,3,5-trazin-2-yl(methyl)carbamoylsulfamoyl]benzoate: D291 (= D283), R292 (= R284), W489 (= W482), S568 (≠ A555)
binding flavin-adenine dinucleotide: R161 (= R153), G223 (= G213), G224 (= G214), T246 (= T238), L247 (= L239), M248 (= M240), M263 (= M255), L264 (= L256), G265 (= G257), M266 (= M258), H267 (= H259), G286 (= G278), V287 (≠ S279), R288 (= R280), D290 (= D282), V293 (= V285), D310 (= D302), I311 (= I303), D329 (≠ P321), V330 (= V322), M405 (= M398), G423 (= G416), G424 (= G417)
binding magnesium ion: D453 (≠ E446), N480 (= N473), H482 (≠ Y475)

1yi0A Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, sulfometuron methyl (see paper)
44% identity, 99% coverage: 5:563/565 of query aligns to 14:576/582 of 1yi0A

query
sites
1yi0A

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