SitesBLAST

O53289 Phosphoserine phosphatase SerB2; PSP; PSPase; O-phosphoserine phosphohydrolase; Protein-serine/threonine phosphatase; EC 3.1.3.3; EC 3.1.3.16 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
44% identity, 75% coverage: 71:277/277 of query aligns to 180:385/409 of O53289

query
sites
O53289

K

R

L

L

V

I

I

V

S

F

D
|
D

M
x
V

D
|
D

S
|
S

T

T

L

L

I

V

S

Q

I

G

E

E

C

V

I

I

D

E

E

M

I

L

A

A

D

A

M

R

F

A

H

G

I

A

K

Q

P

G

Q

Q

V

V

A

A

I

I

T

T

E

E

S

A

A

A

M

M

R

R

G

G

E

E

L

L

N

D

F

F

E

A

Q

E

S

S

L

L

T

Q

Q

R

R

R

V

V

T

A

L

T

L

L

R

A

G

G

L

L

D

P

E

A

K

T

A

V

L

I

D

D

R

D

V

V

Y

-

N

A

E

E

R

Q

L

L

Q

E

L

L

N

M

P

P

G

G

A

A

E

R

T

T

W

T

I

I

S

R

G

T

L

L

K

R

A

R

R

L

D

G

I

F

K

R

F

C

A

G

L

V

V

V

S
|
S

G

G

F

F

D

R

F

R

F

I

T

I

S

E

R

P

L

L

A

A

N

R

R

E

L

L

N

M

L

L

D

D

F

F

S

V

R

A

A

S

N

N

K

E

L

L

A

E

I

I

E

V

Q

D

G

G

V

I

L

L

T

T

G

G

S

R

V

V

G

G

S

P

I

I

V

V

G

D

A

R

Q

P

A

G

K
|
K

A

A

D

K

F

A

L

L

H

R

E

D

L

F

C

A

Q

S

H

Q

L

Y

A

G

I

V

T

P

P

M

K

E

Q

Q

V

T

I

V

A

A

I

V

G

G

D
|
D

G

G

A

A

N

N

D
|
D

L

I

L

D

M

M

M

L

K

G

A

A

G

G

L

L

S

G

M

I

A

A

Y

F

H

N

A

A

K

K

P

P

T

A

V

L

Q

R

A

E

Q

V

A

A

N

D

C

A

V

S

L

L

N

S

Y

H

I

P

G

Y

L

L

D

D

A

T

M

V

L

L

D

F

L

L

A

G

D185 (= D76) mutation to G: Completely abolishes enzymatic activity.; mutation to N: Completely abolishes enzymatic activity.
V186 (≠ M77) mutation to Q: Decreases enzymatic activity by 50%.
D187 (= D78) mutation to N: Decreases enzymatic activity by 15%.
S188 (= S79) mutation to A: No effect on enzymatic activity.
S273 (= S165) mutation to A: Completely abolishes enzymatic activity (PubMed:25521849). Decreases enzymatic activity by 60% (PubMed:25037224).
K318 (= K210) mutation to A: Decreases enzymatic activity by 50%.; mutation to E: Completely abolishes enzymatic activity.
D341 (= D233) mutation to G: Decreases enzymatic activity by 80%.; mutation to N: Decreases enzymatic activity by 85%. Completely abolishes enzymatic activity, does not elicit cytoskeletal rearrangements, and does not suppress IL-8 production after TNF-alpha stimulation; when associated with N-345.
D345 (= D237) mutation to N: Decreases enzymatic activity by 55%. Completely abolishes enzymatic activity, does not elicit cytoskeletal rearrangements, and does not suppress IL-8 production after TNF-alpha stimulation; when associated with N-341.

Sites not aligning to the query:

18 G→A: Does not bind L-serine and correspondingly no oligomeric transitions is observed in the presence of L-serine.
108 G→A: Does not bind L-serine and correspondingly no oligomeric transitions is observed in the presence of L-serine.

1f5sA Crystal structure of phosphoserine phosphatase from methanococcus jannaschii (see paper)
41% identity, 70% coverage: 71:263/277 of query aligns to 5:197/210 of 1f5sA

query
sites
1f5sA

K

K

L

L

V

I

I

L

S

F

D
|
D

M
x
F

D
|
D

S

S

T

T

L

L

I

V

S

N

I

N

E

E

C

T

I

I

D

D

E

E

I

I

A

A

D

R

M

E

F

A

H

G

I

V

K

E

P

E

Q

E

V

V

A

K

I

I

T

T

E

K

S

E

A

A

M

M

R

E

G

G

E

K

L

L

N

N

F

F

E

E

Q

Q

S

S

L

L

T

R

Q

K

R

R

V

V

T

S

L

L

R

K

G

D

L

L

D

P

E

I

K

E

A

K

L

V

D

E

R

K

V

A

Y

I

N

K

E

-

R

R

L

I

Q

T

L

P

N

T

P

E

G

G

A

A

E

E

T

E

W

T

I

I

S

K

G

E

L

L

K

K

A

N

R

R

D

G

I

Y

K

V

F

V

A

A

L

V

V

V

S
|
S

G
|
G

G

G

F

F

D

D

F

I

F

A

T

V

S

N

R

K

L

I

A

K

N

E

R

K

L

L

N

G

L

L

D

D

F

Y

S

A

R

F

A

A

N

N

K

R

L

L

A

I

I

V

E

K

Q

D

G

G

V

K

L

L

T

T

G

G

S

D

V

V

V

E

G

G

S

E

I

V

V

L

G

K

A

E

Q

N

A

A

K
|
K

A

G

D

E

F

I

L

L

H

E

E

K

L

I

C

A

Q

K

H

I

L

E

A

G

I

I

T

N

P

L

K

E

Q

D

V

T

I

V

A

A

I

V

G

G

D
|
D

G

G

A

A

N

N

D
|
D

L

I

L

S

M

M

M

F

K

K

A

K

A

A

G

G

L

L

S

K

M

I

A

A

Y

F

H

C

A

A

K

K

P

P

T

I

V

L

Q

K

A

E

Q

K

A

A

N

D

-

I

C

C

V

I

active site: D10 (= D76), F11 (≠ M77), D12 (= D78), G99 (= G166), K143 (= K210), D170 (= D237)
binding magnesium ion: D10 (= D76), D12 (= D78), D166 (= D233)
binding phosphate ion: D10 (= D76), F11 (≠ M77), D12 (= D78), S98 (= S165), G99 (= G166), K143 (= K210)

Q58989 Phosphoserine phosphatase; PSP; PSPase; O-phosphoserine phosphohydrolase; EC 3.1.3.3 from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) (see 3 papers)
41% identity, 70% coverage: 71:263/277 of query aligns to 6:198/211 of Q58989

query
sites
Q58989

K

K

L

L

V

I

I

L

S

F

D
|
D

M

F

D
|
D

S

S

T

T

L

L

I

V

S

N

I

N

E
|
E

C

T

I

I

D

D

E

E

I

I

A

A

D

R

M

E

F

A

H

G

I

V

K

E

P

E

Q

E

V

V

A

K

I

I

T

T

E

K

S

E

A

A

M

M

R

E

G

G

E

K

L

L

N

N

F

F

E

E

Q

Q

S

S

L

L

T

R

Q

K

R
|
R

V

V

T

S

L

L

R

K

G

D

L

L

D

P

E

I

K

E

A

K

L

V

D

E

R

K

V

A

Y

I

N

K

E

-

R

R

L

I

Q

T

L

P

N

T

P

E

G

G

A

A

E

E

T

E

W

T

I

I

S

K

G

E

L

L

K

K

A

N

R

R

D

G

I

Y

K

V

F

V

A

A

L

V

V

V

S
|
S

G
|
G

G

G

F

F

D

D

F

I

F

A

T

V

S

N

R

K

L

I

A

K

N

E

R

K

L

L

N

G

L

L

D

D

F

Y

S

A

R

F

A

A

N

N

K

R

L

L

A

I

I

V

E

K

Q

D

G

G

V

K

L

L

T

T

G

G

S

D

V

V

V

E

G

G

S

E

I

V

V

L

G

K

A

E

Q

N

A

A

K
|
K

A

G

D

E

F

I

L

L

H

E

E

K

L

I

C

A

Q

K

H

I

L

E

A

G

I

I

T

N

P

L

K

E

Q

D

V

T

I

V

A

A

I

V

G

G

D
|
D

G

G

A

A

N
|
N

D

D

L

I

L

S

M

M

M

F

K

K

A

K

A

A

G

G

L

L

S

K

M

I

A

A

Y

F

H

C

A

A

K

K

P

P

T

I

V

L

Q

K

A

E

Q

K

A

A

N

D

-

I

C

C

V

I

D11 (= D76) active site, Nucleophile; binding Mg(2+); mutation to N: Loss of activity.
D13 (= D78) active site, Proton donor; binding Mg(2+)
E20 (= E85) binding substrate
R56 (= R121) binding substrate
SG 99:100 (= SG 165:166) binding substrate
K144 (= K210) binding substrate
D167 (= D233) binding Mg(2+)
N170 (= N236) binding substrate

1l7nA Transition state analogue of phosphoserine phosphatase (aluminum fluoride complex) (see paper)
41% identity, 70% coverage: 71:263/277 of query aligns to 4:196/209 of 1l7nA

query
sites
1l7nA

K

K

L

L

V

I

I

L

S

F

D
|
D

M
x
F

D
|
D

S

S

T

T

L

L

I

V

S

N

I

N

E

E

C

T

I

I

D

D

E

E

I

I

A

A

D

R

M

E

F

A

H

G

I

V

K

E

P

E

Q

E

V

V

A

K

I

I

T

T

E

K

S

E

A

A

M

M

R

E

G

G

E

K

L

L

N

N

F

F

E

E

Q

Q

S

S

L

L

T

R

Q

K

R

R

V

V

T

S

L

L

R

K

G

D

L

L

D

P

E

I

K

E

A

K

L

V

D

E

R

K

V

A

Y

I

N

-

E

K

R

R

L

I

Q

T

L

P

N

T

P

E

G

G

A

A

E

E

T

E

W

T

I

I

S

K

G

E

L

L

K

K

A

N

R

R

D

G

I

Y

K

V

F

V

A

A

L

V

V

V

S
|
S

G
|
G

G

G

F

F

D

D

F

I

F

A

T

V

S

N

R

K

L

I

A

K

N

E

R

K

L

L

N

G

L

L

D

D

F

Y

S

A

R

F

A

A

N

N

K

R

L

L

A

I

I

V

E

K

Q

D

G

G

V

K

L

L

T

T

G

G

S

D

V

V

V

E

G

G

S

E

I

V

V

L

G

K

A

E

Q

N

A

A

K
|
K

A

G

D

E

F

I

L

L

H

E

E

K

L

I

C

A

Q

K

H

I

L

E

A

G

I

I

T

N

P

L

K

E

Q

D

V

T

I

V

A

A

I

V

G

G

D
|
D

G

G

A

A

N
|
N

D
|
D

L

I

L

S

M

M

M

F

K

K

A

K

A

A

G

G

L

L

S

K

M

I

A

A

Y

F

H

C

A

A

K

K

P

P

T

I

V

L

Q

K

A

E

Q

K

A

A

N

D

-

I

C

C

V

I

active site: D9 (= D76), F10 (≠ M77), D11 (= D78), G98 (= G166), K142 (= K210), D169 (= D237)
binding aluminum fluoride: D9 (= D76), F10 (≠ M77), D11 (= D78), S97 (= S165), K142 (= K210)
binding tetrafluoroaluminate ion: D9 (= D76), F10 (≠ M77), D11 (= D78), S97 (= S165), G98 (= G166), K142 (= K210), N168 (= N236)
binding magnesium ion: D9 (= D76), D11 (= D78), D165 (= D233)

A0QJI1 Phosphoserine phosphatase; PSP; PSPase; O-phosphoserine phosphohydrolase; EC 3.1.3.3 from Mycobacterium avium (strain 104) (see paper)
44% identity, 75% coverage: 71:277/277 of query aligns to 182:387/411 of A0QJI1

query
sites
A0QJI1

K

R

L

L

V

I

I

V

S

F

D
|
D

M

V

D
|
D

S

S

T

T

L

L

I

V

S

Q

I

G

E

E

C

V

I

I

D

E

E

M

I

L

A

A

D

A

M

K

F

A

H

G

I

A

K

E

P

G

Q

Q

V

V

A

A

I

I

T

T

E

D

S

A

A

A

M

M

R

R

G

G

E

E

L

L

N

D

F

F

E

A

Q

Q

S

S

L

L

T

Q

Q

Q

R

R

V

V

T

A

L

T

L

L

R

A

G

G

L

L

D

P

E

A

K

T

A

V

L

I

D

D

R

E

V

V

Y

A

N

G

E

Q

R

-

L

L

Q

E

L

L

N

M

P

P

G

G

A

A

E

R

T

T

W

T

I

L

S

R

G

T

L

L

K

R

A

R

R

L

D

G

I

Y

K

A

F

C

A

G

L

V

V

V

S

S

G

G

F

F

D

R

F

R

F

I

T

I

S

E

R

P

L

L

A

A

N

E

R

E

L

L

N

M

L

L

D

D

F

Y

S

V

R

A

A

A

N

N

K

E

L

L

A

E

I

I

E

V

Q

D

G

G

V

T

L

L

T

T

G

G

S

R

V

V

G

G

S

P

I

I

V

I

G

D

A

R

Q

A

A

G

K

K

A

A

D

T

F

A

L

L

H

R

E

E

L

F

C

A

Q

Q

H

R

L

A

A

G

I

V

T

P

P

M

K

A

Q

Q

V

T

I

V

A

A

I

V

G

G

D
|
D

G

G

A

A

N

N

D

D

L

I

L

D

M

M

M

L

K

A

A

A

G

G

L

L

S

G

M

I

A

A

Y

F

H

N

A

A

K

K

P

P

T

A

V

L

Q

R

A

E

Q

V

A

A

N

D

C

A

V

S

L

L

N

S

Y

H

I

P

G

Y

L

L

D

D

A

T

M

V

L

L

D

F

L

L

A

G

D187 (= D76) binding Mg(2+)
D189 (= D78) binding Mg(2+)
D343 (= D233) binding Mg(2+)

8a21A Crystal structure of phosphoserine phosphatase serb from mycobacterium avium in complex with phenylimidazole (see paper)
44% identity, 75% coverage: 71:277/277 of query aligns to 178:383/396 of 8a21A

query
sites
8a21A

K

R

L

L

V

I

I

V

S

F

D
|
D

M

V

D
|
D

S

S

T

T

L

L

I

V

S

Q

I

G

E
|
E

C
x
V

I
|
I

D

E

E

M

I

L

A

A

D

A

M

K

F

A

H

G

I

A

K

E

P

G

Q

Q

V

V

A

A

I

I

T
|
T

E

D

S

A

A

A

M
|
M

R

R

G

G

E

E

L

L

N

D

F
|
F

E

A

Q

Q

S

S

L

L

T

Q

Q

Q

R
|
R

V

V

T

A

L

T

L

L

R

A

G

G

L

L

D

P

E

A

K

T

A

V

L

I

D

D

R

E

V

V

Y

A

N

G

E

Q

R

-

L

L

Q

E

L

L

N

M

P

P

G

G

A

A

E

R

T

T

W

T

I

L

S

R

G

T

L

L

K

R

A

R

R

L

D

G

I

Y

K

A

F

C

A

G

L

V

V

V

S

S

G

G

G
|
G

F

F

D

R

F

R

F

I

T

I

S

E

R

P

L

L

A

A

N

E

R

E

L

L

N

M

L

L

D

D

F

Y

S

V

R

A

A

A

N

N

K

E

L

L

A

E

I

I

E

V

Q

D

G

G

V

T

L

L

T

T

G

G

S

R

V

V

G

G

S

P

I

I

V

I

G

D

A

R

Q

A

A

G

K

K

A

A

D

T

F

A

L

L

H

R

E

E

L

F

C

A

Q

Q

H

R

L

A

A

G

I

V

T

P

P

M

K

A

Q

Q

V

T

I

V

A

A

I

V

G

G

D
|
D

G

G

A

A

N

N

D

D

L

I

L

D

M

M

M

L

K

A

A

A

G

G

L

L

S

G

M

I

A

A

Y

F

H

N

A

A

K

K

P

P

T

A

V

L

Q

R

A

E

Q

V

A

A

N

D

C

A

V

S

L

L

N

S

Y

H

I

P

G

Y

L

L

D

D

A

T

M

V

L

L

D

F

L

L

A

G

binding magnesium ion: D183 (= D76), D185 (= D78), D339 (= D233)
binding 4-phenyl-1h-imidazole: D185 (= D78), E192 (= E85), V193 (≠ C86), I194 (= I87), T211 (= T104), M215 (= M108), F221 (= F114), R228 (= R121), G273 (= G167)

Sites not aligning to the query:

binding 4-phenyl-1h-imidazole: 13, 18, 37

8a1zA Crystal structure of phosphoserine phosphatase serb from mycobacterium avium in complex with 1-(2,4-dichlorophenyl)-3-hydroxyurea (see paper)
44% identity, 75% coverage: 71:277/277 of query aligns to 178:383/396 of 8a1zA

query
sites
8a1zA

K

R

L

L

V

I

I

V

S

F

D
|
D

M

V

D
|
D

S

S

T

T

L

L

I

V

S

Q

I

G

E
|
E

C

V

I

I

D

E

E

M

I

L

A

A

D

A

M

K

F

A

H

G

I

A

K

E

P

G

Q

Q

V

V

A

A

I

I

T

T

E

D

S

A

A

A

M
|
M

R

R

G

G

E

E

L

L

N

D

F
|
F

E

A

Q

Q

S

S

L
|
L

T

Q

Q

Q

R
|
R

V

V

T

A

L

T

L

L

R

A

G

G

L

L

D

P

E

A

K

T

A

V

L

I

D

D

R

E

V

V

Y

A

N

G

E

Q

R

-

L

L

Q

E

L

L

N

M

P

P

G

G

A

A

E

R

T

T

W

T

I

L

S

R

G

T

L

L

K

R

A

R

R

L

D

G

I

Y

K

A

F

C

A

G

L

V

V

V

S

S

G
|
G

G

G

F
|
F

D

R

F

R

F

I

T

I

S

E

R

P

L

L

A

A

N

E

R

E

L

L

N

M

L

L

D

D

F

Y

S

V

R

A

A

A

N

N

K

E

L

L

A

E

I

I

E

V

Q

D

G

G

V

T

L

L

T

T

G

G

S

R

V

V

G

G

S

P

I

I

V

I

G

D

A

R

Q

A

A

G

K

K

A

A

D

T

F

A

L

L

H

R

E

E

L

F

C

A

Q

Q

H

R

L

A

A

G

I

V

T

P

P

M

K

A

Q

Q

V

T

I

V

A

A

I

V

G

G

D
|
D

G

G

A

A

N

N

D

D

L

I

L

D

M

M

M

L

K

A

A

A

G

G

L

L

S

G

M

I

A

A

Y

F

H

N

A

A

K

K

P

P

T

A

V

L

Q

R

A

E

Q

V

A

A

N

D

C

A

V

S

L

L

N

S

Y

H

I

P

G

Y

L

L

D

D

A

T

M

V

L

L

D

F

L

L

A

G

binding 1-(2,4-dichlorophenyl)-3-oxidanyl-urea: D185 (= D78), E192 (= E85), M215 (= M108), F221 (= F114), L225 (= L118), R228 (= R121), G272 (= G166), F274 (= F168), D339 (= D233)
binding magnesium ion: D183 (= D76), D185 (= D78), D339 (= D233)

5jlpA Crystal structure of mycobacterium avium serb2 in complex with serine at act domain
44% identity, 75% coverage: 71:277/277 of query aligns to 178:383/396 of 5jlpA

query
sites
5jlpA

K

R

L

L

V

I

I

V

S

F

D
|
D

M
x
V

D
|
D

S

S

T

T

L

L

I

V

S

Q

I

G

E

E

C

V

I

I

D

E

E

M

I

L

A

A

D

A

M

K

F

A

H

G

I

A

K

E

P

G

Q

Q

V

V

A

A

I

I

T

T

E

D

S

A

A

A

M

M

R

R

G

G

E

E

L

L

N

D

F

F

E

A

Q

Q

S

S

L

L

T

Q

Q

Q

R

R

V

V

T

A

L

T

L

L

R

A

G

G

L

L

D

P

E

A

K

T

A

V

L

I

D

D

R

E

V

V

Y

A

N

G

E

Q

R

-

L

L

Q

E

L

L

N

M

P

P

G

G

A

A

E

R

T

T

W

T

I

L

S

R

G

T

L

L

K

R

A

R

R

L

D

G

I

Y

K

A

F

C

A

G

L

V

V

V

S

S

G
|
G

G

G

F

F

D

R

F

R

F

I

T

I

S

E

R

P

L

L

A

A

N

E

R

E

L

L

N

M

L

L

D

D

F

Y

S

V

R

A

A

A

N

N

K

E

L

L

A

E

I

I

E

V

Q

D

G

G

V

T

L

L

T

T

G

G

S

R

V

V

G

G

S

P

I

I

V

I

G

D

A

R

Q

A

A

G

K
|
K

A

A

D

T

F

A

L

L

H

R

E

E

L

F

C

A

Q

Q

H

R

L

A

A

G

I

V

T

P

P

M

K

A

Q

Q

V

T

I

V

A

A

I

V

G

G

D
|
D

G

G

A

A

N

N

D
|
D

L

I

L

D

M

M

M

L

K

A

A

A

G

G

L

L

S

G

M

I

A

A

Y

F

H

N

A

A

K

K

P

P

T

A

V

L

Q

R

A

E

Q

V

A

A

N

D

C

A

V

S

L

L

N

S

Y

H

I

P

G

Y

L

L

D

D

A

T

M

V

L

L

D

F

L

L

A

G

active site: D183 (= D76), V184 (≠ M77), D185 (= D78), G272 (= G166), K316 (= K210), D343 (= D237)
binding magnesium ion: D183 (= D76), D339 (= D233)

Sites not aligning to the query:

binding serine: 13, 14

1l7pA Substrate bound phosphoserine phosphatase complex structure (see paper)
41% identity, 70% coverage: 71:263/277 of query aligns to 3:195/208 of 1l7pA

query
sites
1l7pA

K

K

L

L

V

I

I

L

S

F

D
x
N

M
x
F

D
|
D

S

S

T

T

L

L

I

V

S

N

I

N

E
|
E

C

T

I

I

D

D

E

E

I

I

A

A

D

R

M

E

F

A

H

G

I

V

K

E

P

E

Q

E

V

V

A

K

I

I

T

T

E

K

S

E

A

A

M
|
M

R

E

G

G

E

K

L

L

N

N

F
|
F

E

E

Q

Q

S

S

L

L

T

R

Q

K

R
|
R

V

V

T

S

L

L

R

K

G

D

L

L

D

P

E

I

K

E

A

K

L

V

D

E

R

K

V

A

Y

I

N

-

E

K

R

R

L

I

Q

T

L

P

N

T

P

E

G

G

A

A

E

E

T

E

W

T

I

I

S

K

G

E

L

L

K

K

A

N

R

R

D

G

I

Y

K

V

F

V

A

A

L

V

V

V

S
|
S

G
|
G

G

G

F

F

D

D

F

I

F

A

T

V

S

N

R

K

L

I

A

K

N

E

R

K

L

L

N

G

L

L

D

D

F

Y

S

A

R

F

A

A

N

N

K

R

L

L

A

I

I

V

E

K

Q

D

G

G

V

K

L

L

T

T

G

G

S

D

V

V

V

E

G

G

S

E

I

V

V

L

G

K

A

E

Q

N

A

A

K
|
K

A

G

D

E

F

I

L

L

H

E

E

K

L

I

C

A

Q

K

H

I

L

E

A

G

I

I

T

N

P

L

K

E

Q

D

V

T

I

V

A

A

I

V

G

G

D

D

G

G

A

A

N

N

D
|
D

L

I

L

S

M

M

M

F

K

K

A

K

A

A

G

G

L

L

S

K

M

I

A

A

Y

F

H

C

A

A

K

K

P

P

T

I

V

L

Q

K

A

E

Q

K

A

A

N

D

-

I

C

C

V

I

active site: N8 (≠ D76), F9 (≠ M77), D10 (= D78), G97 (= G166), K141 (= K210), D168 (= D237)
binding phosphoserine: N8 (≠ D76), F9 (≠ M77), D10 (= D78), E17 (= E85), M40 (= M108), F46 (= F114), R53 (= R121), S96 (= S165), G97 (= G166), K141 (= K210)

1l7oA Crystal structure of phosphoserine phosphatase in apo form (see paper)
39% identity, 70% coverage: 71:263/277 of query aligns to 3:187/200 of 1l7oA

query
sites
1l7oA

K

K

L

L

V

I

I

L

S

F

D

N

M

F

D

D

S

S

T

T

L

L

I

V

S

N

I

N

E

E

C

T

I

I

D

D

E

E

I

I

A

A

D

R

M

E

F

A

H

G

I

V

K

E

P

E

Q

E

V

V

A

K

I

I

T

T

E

-

S

-

A

-

M

-

R

-

G

-

E

-

L

-

N

N

F

F

E

E

Q

Q

S

S

L

L

T

R

Q

K

R

R

V

V

T

S

L

L

R

K

G

D

L

L

D

P

E

I

K

E

A

K

L

V

D

E

R

K

V

A

Y

I

N

-

E

K

R

R

L

I

Q

T

L

P

N

T

P

E

G

G

A

A

E

E

T

E

W

T

I

I

S

K

G

E

L

L

K

K

A

N

R

R

D

G

I

Y

K

V

F

V

A

A

L

V

V

V

S

S

G

G

F

F

D

D

F

I

F

A

T

V

S

N

R

K

L

I

A

K

N

E

R

K

L

L

N

G

L

L

D

D

F

Y

S

A

R

F

A

A

N

N

K

R

L

L

A

I

I

V

E

K

Q

D

G

G

V

K

L

L

T

T

G

G

S

D

V

V

V

E

G

G

S

E

I

V

V

L

G

K

A

E

Q

N

A

A

K

K

A

G

D

E

F

I

L

L

H

E

E

K

L

I

C

A

Q

K

H

I

L

E

A

G

I

I

T

N

P

L

K

E

Q

D

V

T

I

V

A

A

I

V

G

G

D

D

G

G

A

A

N

N

D

D

L

I

L

S

M

M

M

F

K

K

A

K

A

A

G

G

L

L

S

K

M

I

A

A

Y

F

H

C

A

A

K

K

P

P

T

I

V

L

Q

K

A

E

Q

K

A

A

N

D

-

I

C
|
C

V

I

binding zinc ion: C186 (= C262)

Sites not aligning to the query:

binding zinc ion: 188

3m1yC Crystal structure of a phosphoserine phosphatase (serb) from helicobacter pylori
35% identity, 70% coverage: 71:265/277 of query aligns to 4:196/208 of 3m1yC

query
sites
3m1yC

K

K

L

L

V

A

I

V

S

F

D
|
D

M
x
F

D
|
D

S

S

T

T

L

L

I

V

S

N

I

A

E

E

C

T

I

I

D

E

E

S

I

L

A

A

D

R

M

A

F

W

H

G

I

V

K

F

P

D

Q

E

V

V

A

K

A

T

I

I

T

T

E

L

S

K

A

A

M

M

R

N

G

G

E

T

L

-

N

D

F

F

E

H

Q

K

S

S

L

L

T

I

Q

L

R

R

V

V

T

S

L

K

L

L

R

K

G

N

L

M

D

P

E

L

K

K

A

-

L

L

D

A

R

K

V

E

Y

V

N

C

E

E

R

S

L

L

Q

P

L

L

N

F

P

E

G

G

A

A

E

L

T

E

W

L

I

V

S

S

G

A

L

L

K

K

A

E

R

K

D

N

I

Y

K

K

F

V

A

V

L

C

V

F

S

S

G
|
G

G

G

F

F

D

D

F

L

F

A

T

T

S

N

R

H

L

Y

A

R

N

D

R

L

L

L

N

H

L

L

D

D

F

A

S

A

R

F

A

S

N

N

K

T

L

L

A

I

I

V

E

E

Q

N

G

D

V

A

L

L

T

N

G

G

S

L

V

V

V

T

G

G

S

H

I

M

V

M

G

F

A

S

Q

H

A

S

K
|
K

A

G

D

E

F

M

L

L

H

L

E

V

L

L

C

Q

Q

R

H

L

L

L

A

N

I

I

T

S

P

K

K

T

Q

N

V

T

I

L

A

V

I

V

G

G

D
|
D

G

G

A

A

N

N

D
|
D

L

L

L

S

M

M

M

F

K

K

A

H

A

A

G

H

L

I

S

K

M

I

A

A

Y

F

H

N

A

A

K

K

P

E

T

V

V

L

Q

K

A

Q

Q

H

A

A

N

T

C

H

V

C

L

I

N

N

active site: D9 (= D76), F10 (≠ M77), D11 (= D78), G97 (= G166), K141 (= K210), D168 (= D237)
binding magnesium ion: D9 (= D76), D11 (= D78), D164 (= D233)

1l8oA Molecular basis for the local conformational rearrangement of human phosphoserine phosphatase (see paper)
31% identity, 60% coverage: 73:238/277 of query aligns to 14:181/222 of 1l8oA

query
sites
1l8oA

V

V

I

C

S

F

D
|
D

M
x
V

D
|
D

S

S

T

T

L

V

I

I

S

R

I

E

E

E

C

G

I

I

D

D

E

E

I

L

A

A

D

K

M

I

F

C

H

G

I

V

K

E

P

D

Q

A

V

V

A

S

A

E

I

M

T

T

E

R

S

R

A

A

M

M

R

G

G

G

E

A

L

V

N

P

F

F

E

K

Q

A

S

A

L

L

T

T

Q

E

R

R

V

L

T

A

L

L

L

I

R

Q

G

P

L

S

D

R

E

E

K

Q

A

V

L

Q

D

R

R

L

V

I

Y

A

N

E

E

Q

R

P

L

P

Q

H

L

L

N

T

P

P

G

G

A

I

E

R

T

E

W

L

I

V

S

S

G

R

L

L

K

Q

A

E

R

R

D

N

I

V

K

Q

F

V

A

F

L

L

V

I

S
|
S

G
|
G

G

G

F

F

D

R

F

S

F

I

T

V

S

E

R

H

L

V

A

A

N

S

R

K

L

L

N

N

L

I

D

P

F

A

S

T

R

N

-

V

-

F

A

A

N

N

K

R

L

L

A

K

I

F

E

-

Q

-

G

-

V

Y

L

F

T

N

G

G

S

E

V

Y

V

A

G

G

-

F

-

D

-

E

-

T

-

Q

-

P

-

T

S

A

I

E

V

S

G

G

A

G

Q
x
K

A

G

K

K

A

V

-

I

D

K

F

F

L

L

H

K

E

E

L

K

C

F

Q

H

H

F

L

-

A

-

I

-

T

-

P

-

K

K

Q

K

V

I

I

I

A

M

I

I

G

G

D

D

G
|
G

A

A

N
x
T

D
|
D

L

M

active site: D17 (= D76), V18 (≠ M77), D19 (= D78), G107 (= G166), K155 (≠ Q208), D180 (= D237)
binding phosphate ion: D17 (= D76), D19 (= D78), S106 (= S165), K155 (≠ Q208)
binding serine: G177 (= G234), T179 (≠ N236)

Sites not aligning to the query:

binding serine: 199

1l8lA Molecular basis for the local confomational rearrangement of human phosphoserine phosphatase (see paper)
31% identity, 60% coverage: 73:238/277 of query aligns to 14:181/222 of 1l8lA

query
sites
1l8lA

V

V

I

C

S

F

D
|
D

M
x
V

D
|
D

S

S

T

T

L

V

I

I

S

R

I

E

E

E

C

G

I

I

D

D

E

E

I

L

A

A

D

K

M

I

F

C

H

G

I

V

K

E

P

D

Q

A

V

V

A

S

A

E

I

M

T

T

E

R

S

R

A

A

M

M

R

G

G

G

E

A

L

V

N

P

F

F

E

K

Q

A

S

A

L

L

T

T

Q

E

R

R

V

L

T

A

L

L

L

I

R

Q

G

P

L

S

D

R

E

E

K

Q

A

V

L

Q

D

R

R

L

V

I

Y

A

N

E

E

Q

R

P

L

P

Q

H

L

L

N

T

P

P

G

G

A

I

E

R

T

E

W

L

I

V

S

S

G

R

L

L

K

Q

A

E

R

R

D

N

I

V

K

Q

F

V

A

F

L

L

V

I

S

S

G
|
G

G

G

F

F

D

R

F

S

F

I

T

V

S

E

R

H

L

V

A

A

N

S

R

K

L

L

N

N

L

I

D

P

F

A

S

T

R

N

-

V

-

F

A

A

N

N

K

R

L

L

A

K

I

F

E

-

Q

-

G

-

V

Y

L

F

T

N

G

G

S

E

V

Y

V

A

G

G

-

F

-

D

-

E

-

T

-

Q

-

P

-

T

S

A

I

E

V

S

G

G

A

G

Q
x
K

A

G

K

K

A

V

-

I

D

K

F

F

L

L

H

K

E

E

L

K

C

F

Q

H

H

F

L

-

A

-

I

-

T

-

P

-

K

K

Q

K

V

I

I

I

A

M

I

I

G

G

D
|
D

G
|
G

A

A

N
x
T

D
|
D

L

M

active site: D17 (= D76), V18 (≠ M77), D19 (= D78), G107 (= G166), K155 (≠ Q208), D180 (= D237)
binding d-2-amino-3-phosphono-propionic acid: D17 (= D76), D19 (= D78), G107 (= G166), K155 (≠ Q208), D176 (= D233), G177 (= G234), T179 (≠ N236)

P78330 Phosphoserine phosphatase; PSP; PSPase; L-3-phosphoserine phosphatase; O-phosphoserine phosphohydrolase; EC 3.1.3.3 from Homo sapiens (Human) (see 4 papers)
30% identity, 60% coverage: 73:238/277 of query aligns to 17:184/225 of P78330

query
sites
P78330

V

V

I

C

S

F

D
|
D

M
x
V

D
|
D

S
|
S

T

T

L

V

I

I

S

R

I

E

E
|
E

C

G

I

I

D
|
D

E

E

I

L

A
|
A

D

K

M

I

F

C

H

G

I

V

K

E

P

D

Q

A

V

V

A

S

A

E

I

M

T

T

E

R

S

R

A

A

M
|
M

R
x
G

G

G

E

A

L

V

N

P

F

F

E

K

Q

A

S

A

L

L

T

T

Q

E

R
|
R

V

L

T

A

L

L

L

I

R

Q

G

P

L

S

D

R

E

E

K

Q

A

V

L

Q

D

R

R

L

V

I

Y

A

N

E

E

Q

R

P

L

P

Q

H

L

L

N

T

P

P

G

G

A

I

E

R

T

E

W

L

I

V

S

S

G

R

L

L

K

Q

A

E

R

R

D

N

I

V

K

Q

F

V

A

F

L

L

V

I

S
|
S

G
|
G

F

F

D

R

F

S

F

I

T

V

S

E

R

H

L

V

A

A

N

S

R

K

L

L

N

N

L

I

D

P

F

A

S

T

R

N

-

V

-

F

A

A

N
|
N

K

R

L

L

A

K

I

F

E

-

Q

-

G

-

V

Y

L

F

T

N

G

G

S

E

V

Y

V

A

G

G

-

F

-

D

-

E

-

T

-

Q

-

P

-

T

S

A

I

E

V

S

G

G

A

G

Q
x
K

A

G

K

K

A

V

D

I

F

K

L

L

H

L

E

K

L

E

C

K

Q

F

H

H

L

F

A

-

I

-

T

-

P

-

K

K

Q

K

V

I

I

I

A

M

I

I

G

G

D
|
D

G

G

A

A

N
x
T

D

D

L

M

D20 (= D76) binding Mg(2+)
DVD 20:22 (≠ DMD 76:78) binding L-serine
D22 (= D78) binding Mg(2+)
S23 (= S79) mutation to A: Reduces L-phosphoserine phosphatase activity by about 50%.; mutation to T: Reduces L-phosphoserine phosphatase activity by about 80%.
E29 (= E85) mutation to D: Reduces L-phosphoserine phosphatase activity by about 95%.; mutation to Q: Loss of L-phosphoserine phosphatase activity.
D32 (= D88) to N: in PSPHD; decreased L-phosphoserine phosphatase activity; dbSNP:rs104894035
A35 (= A91) to T: in PSPHD; decreased L-phosphoserine phosphatase activity
M52 (= M108) binding O-phospho-L-serine; to T: in PSPHD; decreased L-phosphoserine phosphatase activity; dbSNP:rs104894036
G53 (≠ R109) binding phosphate
R65 (= R121) mutation R->A,K: Loss of L-phosphoserine phosphatase activity.
SGG 109:111 (= SGG 165:167) binding L-serine; binding O-phospho-L-serine
N133 (= N187) mutation to A: Reduces L-phosphoserine phosphatase activity by about 75%.
K158 (≠ Q208) binding L-serine; binding O-phospho-L-serine
D179 (= D233) binding Mg(2+)
T182 (≠ N236) binding O-phospho-L-serine; binding phosphate; mutation to S: Reduces L-phosphoserine phosphatase activity by about 99%.; mutation to V: Reduces L-phosphoserine phosphatase activity by about 25%.

Sites not aligning to the query:

202 R→A: Reduces L-phosphoserine phosphatase activity by about 99%.; R→K: Reduces L-phosphoserine phosphatase activity by about 95%.

6hyjB Psph human phosphoserine phosphatase (see paper)
30% identity, 60% coverage: 73:238/277 of query aligns to 17:184/223 of 6hyjB

query
sites
6hyjB

V

V

I

C

S

F

D
|
D

M

V

D
|
D

S

S

T

T

L

V

I

I

S

R

I

E

E
|
E

C

G

I

I

D

D

E

E

I

L

A

A

D

K

M

I

F

C

H

G

I

V

K

E

P

D

Q

A

V

V

A

S

A

E

I

M

T

T

E

R

S

R

A

A

M

M

R

G

G

G

E

A

L

V

N

P

F

F

E

K

Q

A

S

A

L

L

T

T

Q

E

R

R

V

L

T

A

L

L

L

I

R

Q

G

P

L

S

D

R

E

E

K

Q

A

V

L

Q

D

R

R

L

V

I

Y

A

N

E

E

Q

R

P

L

P

Q

H

L

L

N

T

P

P

G

G

A

I

E

R

T

E

W

L

I

V

S

S

G

R

L

L

K

Q

A

E

R

R

D

N

I

V

K

Q

F

V

A

F

L

L

V

I

S

S

G

G

F

F

D

R

F

S

F

I

T

V

S

E

R

H

L

V

A

A

N

S

R

K

L

L

N

N

L

I

D

P

F

A

S

T

R

N

-

V

-
x
F

A

A

N

N

K

R

L

L

A

K

I

F

E

-

Q

-

G

-

V

Y

L

F

T

N

G

G

S

E

V

Y

V

A

G

G

-

F

-

D

-

E

-

T

-

Q

-

P

-

T

S

A

I

E

V

S

G

G

A

G

Q

K

A

G

K

K

A

V

D

I

F

K

L

L

H

L

E

K

L

E

C
x
K

Q

F

H

H

L

F

A

-

I

-

T

-

P

-

K

K

Q

K

V

I

I

I

A

M

I

I

G

G

D
|
D

G

G

A

A

N

T

D

D

L

M

binding calcium ion: D20 (= D76), D22 (= D78), D179 (= D233)
binding phosphoserine: F131 (vs. gap), K168 (≠ C218)
binding serine: E29 (= E85)

Sites not aligning to the query:

binding serine: 202

6hyyA Human phosphoserine phosphatase with serine and phosphate (see paper)
30% identity, 60% coverage: 73:238/277 of query aligns to 13:180/221 of 6hyyA

query
sites
6hyyA

V

V

I

C

S

F

D
|
D

M
x
V

D
|
D

S

S

T

T

L

V

I

I

S

R

I

E

E

E

C

G

I

I

D

D

E

E

I

L

A

A

D

K

M

I

F

C

H

G

I

V

K

E

P

D

Q

A

V

V

A

S

A

E

I

M

T

T

E

R

S

R

A

A

M

M

R

G

G

G

E

A

L

V

N

P

F

F

E

K

Q

A

S

A

L

L

T

T

Q

E

R

R

V

L

T

A

L

L

L

I

R

Q

G

P

L

S

D

R

E

E

K

Q

A

V

L

Q

D

R

R

L

V

I

Y

A

N

E

E

Q

R

P

L

P

Q

H

L

L

N

T

P

P

G

G

A

I

E

R

T

E

W

L

I

V

S

S

G

R

L

L

K

Q

A

E

R

R

D

N

I

V

K

Q

F

V

A

F

L

L

V

I

S
|
S

G
|
G

G

G

F

F

D

R

F

S

F

I

T

V

S

E

R

H

L

V

A

A

N

S

R

K

L

L

N

N

L

I

D

P

F

A

S

T

R

N

-

V

-

F

A

A

N

N

K

R

L

L

A

K

I

F

E

-

Q

-

G

-

V

Y

L

F

T

N

G

G

S

E

V

Y

V

A

G

G

-

F

-

D

-

E

-

T

-

Q

-

P

-

T

S

A

I

E

V

S

G

G

A

G

Q
x
K

A

G

K

K

A

V

D

I

F

K

L

L

H

L

E

K

L

E

C

K

Q

F

H

H

L

F

A

-

I

-

T

-

P

-

K

K

Q

K

V

I

I

I

A

M

I

I

G

G

D
|
D

G

G

A

A

N

T

D

D

L

M

binding magnesium ion: D16 (= D76), D18 (= D78), D175 (= D233)
binding serine: D16 (= D76), V17 (≠ M77), D18 (= D78), S105 (= S165), G106 (= G166), K154 (≠ Q208)

6q6jB Human phosphoserine phosphatase with substrate analogue homo-cysteic acid (see paper)
30% identity, 60% coverage: 73:238/277 of query aligns to 13:180/217 of 6q6jB

query
sites
6q6jB

V

V

I

C

S

F

D
|
D

M
x
V

D
|
D

S

S

T

T

L

V

I

I

S

R

I

E

E

E

C

G

I

I

D

D

E

E

I

L

A

A

D

K

M

I

F

C

H

G

I

V

K

E

P

D

Q

A

V

V

A

S

A

E

I

M

T

T

E

R

S

R

A

A

M

M

R

G

G

G

E

A

L

V

N

P

F
|
F

E

K

Q

A

S

A

L

L

T

T

Q

E

R

R

V

L

T

A

L

L

L

I

R

Q

G

P

L

S

D

R

E

E

K

Q

A

V

L

Q

D

R

R

L

V

I

Y

A

N

E

E

Q

R

P

L

P

Q

H

L

L

N

T

P

P

G

G

A

I

E

R

T

E

W

L

I

V

S

S

G

R

L

L

K

Q

A

E

R

R

D

N

I

V

K

Q

F

V

A

F

L

L

V

I

S
|
S

G
|
G

F

F

D

R

F

S

F

I

T

V

S

E

R

H

L

V

A

A

N

S

R

K

L

L

N

N

L

I

D

P

F

A

S

T

R

N

-

V

-

F

A

A

N

N

K

R

L

L

A

K

I

F

E

-

Q

-

G

-

V

Y

L

F

T

N

G

G

S

E

V

Y

V

A

G

G

-

F

-

D

-

E

-

T

-

Q

-

P

-

T

S

A

I

E

V

S

G

G

A

G

Q
x
K

A

G

K

K

A

V

D

I

F

K

L

L

H

L

E

K

L

E

C

K

Q

F

H

H

L

F

A

-

I

-

T

-

P

-

K

K

Q

K

V

I

I

I

A

M

I

I

G

G

D
|
D

G

G

A

A

N
x
T

D

D

L

M

binding calcium ion: D16 (= D76), D18 (= D78), D175 (= D233)
binding (2~{S})-2-azanyl-4-sulfo-butanoic acid: D16 (= D76), V17 (≠ M77), D18 (= D78), F54 (= F114), S105 (= S165), G106 (= G166), G107 (= G167), K154 (≠ Q208), T178 (≠ N236)

4ap9A Crystal structure of phosphoserine phosphatase from t.Onnurineus in complex with ndsb-201 (see paper)
27% identity, 65% coverage: 71:249/277 of query aligns to 10:174/200 of 4ap9A

query
sites
4ap9A

K

K

L

V

V

A

I

V

S

I

D
|
D

M
x
I

D
x
E

S

G

T

T

L

L

I

T

S

D

I

F

E

E

C

F

I

W

D

R

E

E

I

M

A

A

D
x
R

M
x
I

F
x
T

H

G

I

-

K

K

P

R

Q

E

V

I

A

E

I

L

T

L

E

E

S

K

A

G

M
x
L

R

S

G

G

E

E

L

V

N

E

F
x
W

E

L

Q

D

S

S

L

L

T

L

Q

K

R

R

V

V

T

G

L

L

L

I

R

R

G

G

L

I

D

D

E

E

K

G

A

T

L

F

D

L

R

R

V

T

Y

-

N

R

E

E

R

K

L

V

Q

N

L

V

N

S

P

P

G

E

A

A

E

R

T

E

W

L

I

V

S

E

G

T

L

L

K

R

A

E

R

K

D

G

I

F

K

K

F

V

A

V

L

L

V

I

S

S

G
|
G

G

S

F

F

D

E

F

E

F

V

T

L

S

E

R

P

L

F

A

K

N

E

R

-

L

L

N

G

L

D

D

E

F

F

S

M

R

-

A

A

N

N

K

R

L

A

A

I

I

F

E

E

Q

D

G

G

V

K

L

F

T

Q

G

G

S

I

V

R

V

-

G

-

S

-

I

-

V

L

G

R

A

F

Q

R

A
x
D

K
|
K

A

G

D

E

F

F

L

L

H

K

E

R

L

F

C

R

Q

D

H

G

L

F

A

-

I

-

T

-

P

-

K

-

Q

-

V

I

I

L

A

A

I

M

G

G

D

D

G

G

A
x
Y

N
x
A

D
|
D

L

A

L

K

M

M

M

F

K

E

A

R

A

A

G

D

L

M

S

G

M

I

A

A

active site: D15 (= D76), I16 (≠ M77), E17 (≠ D78), G103 (= G166), K141 (= K210), D162 (= D237)
binding 3-pyridinium-1-ylpropane-1-sulfonate: R31 (≠ D92), I32 (≠ M93), T33 (≠ F94), L46 (≠ M108), W52 (≠ F114), D140 (≠ A209), K141 (= K210), Y160 (≠ A235), A161 (≠ N236)

6iuyA Structure of dsgpdh of dunaliella salina (see paper)
30% identity, 39% coverage: 73:181/277 of query aligns to 17:127/585 of 6iuyA

query
sites
6iuyA

V

V

I

C

S

F

D
|
D

M

V

D
|
D

S

R

T

T

L

V

I

T

S

T

I

D

E

A

C

S

I

V

D

G

E

L

I

L

A

A

D

K

M

F

F

M

H

G

I

I

K

E

P

D

Q

E

V

A

A

Q

A

S

I

L

T

T

E

E

S

Q

A

A

M

N

R

R

G

G

E

E

L

I

N

N

F

L

E

T

Q

K

S

A

L

F

T

E

Q

D

R

R

V

L

T

A

L

K

L

L

R

N

G

-

L

F

D

T

E

P

K

T

A

D

L

I

D

D

R

R

V

F

Y

L

N

E

E

E

R

H

-

P

-

A

-

H

L

T

Q

R

L

L

N

V

P

P

G

G

A

V

E

E

T

N

W

L

I

I

S

A

G

A

L

L

K

K

A

A

R

R

D

G

I

V

K

E

F

V

A

F

L

L

V

I

S

S

G

G

F

F

D

R

F

E

F

M

T

A

S

L

R

P

L

I

A

A

N

S

R

H

L

L

N

K

L

I

binding magnesium ion: D20 (= D76), D22 (= D78)

Sites not aligning to the query:

binding magnesium ion: 175
binding nicotinamide-adenine-dinucleotide: 233, 234, 235, 236, 268, 290, 321, 324, 349, 381, 382, 497, 529, 530, 532

Query Sequence

>WP_013835004.1 NCBI__GCF_000214825.1:WP_013835004.1
MKHTLVIHHNQLDQVQKDQLSASIGEPFPHNNHWRIISEQTINAPDLAELRHQLQLDINI
LPNDFEPAEVKLVISDMDSTLISIECIDEIADMFHIKPQVAAITESAMRGELNFEQSLTQ
RVTLLRGLDEKALDRVYNERLQLNPGAETWISGLKARDIKFALVSGGFDFFTSRLANRLN
LDFSRANKLAIEQGVLTGSVVGSIVGAQAKADFLHELCQHLAITPKQVIAIGDGANDLLM
MKAAGLSMAYHAKPTVQAQANCVLNYIGLDAMLDLLA

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory