Comparing WP_013835177.1 NCBI__GCF_000214825.1:WP_013835177.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
5ey5A Lbcats
43% identity, 89% coverage: 1:244/275 of query aligns to 1:236/261 of 5ey5A
1tjpA Crystal structure of wild-type tryptophan synthase complexed with 1- [(2-hydroxylphenyl)amino]3-glycerolphosphate (see paper)
36% identity, 99% coverage: 1:271/275 of query aligns to 1:267/267 of 1tjpA
2clkA Tryptophan synthase in complex with d-glyceraldehyde 3- phosphate (g3p) (see paper)
36% identity, 99% coverage: 1:271/275 of query aligns to 1:267/267 of 2clkA
8b08A Tryptophan synthase - cryo-trapping by the spitrobot crystal plunger after 30 sec (see paper)
36% identity, 99% coverage: 1:272/275 of query aligns to 2:269/269 of 8b08A
1k3uA Crystal structure of wild-type tryptophan synthase complexed with n- [1h-indol-3-yl-acetyl]aspartic acid (see paper)
36% identity, 99% coverage: 1:272/275 of query aligns to 1:268/268 of 1k3uA
2trsA Crystal structures of mutant (betak87t) tryptophan synthase alpha2 beta2 complex with ligands bound to the active sites of the alpha and beta subunits reveal ligand-induced conformational changes (see paper)
37% identity, 99% coverage: 1:272/275 of query aligns to 1:262/262 of 2trsA
1cx9A Crystal structure of the complex of bacterial tryptophan synthase with the transition state analogue inhibitor 4-(2-aminophenylthio)- butylphosphonic acid (see paper)
37% identity, 98% coverage: 3:271/275 of query aligns to 2:264/264 of 1cx9A
1cw2A Crystal structure of the complex of bacterial tryptophan synthase with the transition state analogue inhibitor 4-(2-hydroxyphenylsulfinyl)- butylphosphonic acid (see paper)
37% identity, 98% coverage: 3:271/275 of query aligns to 2:264/264 of 1cw2A
1c9dA Crystal structure of the complex of bacterial tryptophan synthase with the transition state analogue inhibitor 4-(2-hydroxy-4- fluorophenylthio)-butylphosphonic acid (see paper)
37% identity, 98% coverage: 3:271/275 of query aligns to 2:264/264 of 1c9dA
1c29A Crystal structure of the complex of bacterial tryptophan synthase with the transition state analogue inhibitor 4-(2-hydroxyphenylthio)-1- butenylphosphonic acid (see paper)
37% identity, 98% coverage: 3:271/275 of query aligns to 2:264/264 of 1c29A
3cepA Structure of a tryptophan synthase quinonoid intermediate (see paper)
36% identity, 98% coverage: 3:271/275 of query aligns to 2:266/266 of 3cepA
7jllA The internal aldimine crystal structure of salmonella typhimurium tryptophan synthase mutant beta-s377a in complex with inhibitor 2- ({[4-(trifluoromethoxy)phenyl]sulfonyl}amino)ethyl dihydrogen phosphate (f9f) at the alpha-site, cesium ion at the metal coordination site and l-tryptophan at the enzyme beta-site
36% identity, 98% coverage: 3:272/275 of query aligns to 2:267/267 of 7jllA
6xncA Salmonella typhimurium tryptophan synthase complexed with l-tryptophan and d-glycerol-3-phosphate (see paper)
36% identity, 98% coverage: 3:272/275 of query aligns to 2:267/267 of 6xncA
1k7eA Crystal structure of wild-type tryptophan synthase complexed with n- [1h-indol-3-yl-acetyl]glycine acid (see paper)
36% identity, 99% coverage: 1:272/275 of query aligns to 1:261/261 of 1k7eA
1a50A Crystal structure of wild-type tryptophan synthase complexed with 5- fluoroindole propanol phosphate (see paper)
37% identity, 98% coverage: 3:271/275 of query aligns to 2:260/260 of 1a50A
2clhA Tryptophan synthase in complex with (naphthalene-2'-sulfonyl)-2-amino- 1-ethylphosphate (f19) (see paper)
36% identity, 99% coverage: 1:271/275 of query aligns to 1:258/258 of 2clhA
2cliA Tryptophan synthase in complex with n-(4'- trifluoromethoxybenzenesulfonyl)-2-amino-1-ethylphosphate (f9) (see paper)
36% identity, 99% coverage: 1:272/275 of query aligns to 1:258/258 of 2cliA
1k7fA Crystal structure of wild-type tryptophan synthase complexed with n- [1h-indol-3-yl-acetyl]valine acid (see paper)
35% identity, 99% coverage: 1:271/275 of query aligns to 1:253/253 of 1k7fA
6uapC Crystal structure of tryptophan synthase from m. Tuberculosis - open form with brd6309 bound
39% identity, 92% coverage: 2:254/275 of query aligns to 2:239/250 of 6uapC
6u6cE Crystal structure of tryptophan synthase from m. Tuberculosis - aminoacrylate- and gsk2-bound form (see paper)
38% identity, 92% coverage: 2:254/275 of query aligns to 2:236/245 of 6u6cE
Sites not aligning to the query:
>WP_013835177.1 NCBI__GCF_000214825.1:WP_013835177.1
MNRIEARFASLQAQQKTALIPYLTAGDPHPDMTVDLMHYLVEQGADLLELGVPFSDPLAD
GPTIQKAVERALAHRVTLRDVLAMVAKFREQDNNTPVILMGYLNPVEAMGEAEFATSAVK
AGLDGILTVDMPPEESVGYHDTMASQGLSCIFLVSPTTPASRLGAIAEQGKGFVYYVSLK
GVTGVGQADVGDVETHVKALKEVINLPVGIGFGVRDGQAAYKMAQHGAGVIIGSALVSII
EQNQTAGLVQIKAVLTPKMVEFRQAIDAADRGDVL
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory