SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing WP_013836069.1 NCBI__GCF_000214825.1:WP_013836069.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

O23346 Imidazoleglycerol-phosphate dehydratase 2, chloroplastic; IGPD 2; Protein HISTIDINE BIOSYNTHESIS 5B; EC 4.2.1.19 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
51% identity, 99% coverage: 3:197/197 of query aligns to 75:269/272 of O23346

query
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O23346

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E86 (= E14) binding substrate
H112 (= H40) binding Mn(2+)
112:120 (vs. 40:48, 67% identical) binding substrate
H138 (= H66) binding Mn(2+)
HHTNE 138:142 (≠ HHTVE 66:70) binding substrate
H139 (= H67) binding Mn(2+)
E142 (= E70) binding Mn(2+)
R164 (= R92) binding substrate
R186 (= R114) binding substrate
H210 (≠ E138) binding Mn(2+)
H234 (= H162) binding Mn(2+)
234:242 (vs. 162:170, 56% identical) binding substrate
H235 (= H163) binding Mn(2+)
E238 (= E166) binding Mn(2+)
SSK 264:266 (≠ STK 192:194) binding substrate

Sites not aligning to the query:

73 E→Q: Loss of activity.

P34047 Imidazoleglycerol-phosphate dehydratase 1, chloroplastic; IGPD 1; Protein HISTIDINE BIOSYNTHESIS 5A; EC 4.2.1.19 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
51% identity, 99% coverage: 2:197/197 of query aligns to 72:267/270 of P34047

query
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P34047

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H110 (= H40) binding Mn(2+)
H136 (= H66) binding Mn(2+)
H137 (= H67) binding Mn(2+)
E140 (= E70) binding Mn(2+)
H208 (≠ E138) binding Mn(2+)
H232 (= H162) binding Mn(2+)
H233 (= H163) binding Mn(2+)
E236 (= E166) binding Mn(2+)

5el9A A. Thaliana igpd2 in complex with the triazole-phosphonate inhibitor, (s)-c348, to 1.1a resolution (see paper)
51% identity, 99% coverage: 3:197/197 of query aligns to 2:196/199 of 5el9A

query
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5el9A

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binding [(2S)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]phosphonic acid: R91 (= R92), R113 (= R114), S191 (= S192), K193 (= K194)

5ekwA A. Thaliana igpd2 in complex with the racemate of the triazole- phosphonate inhibitor, c348 (see paper)
51% identity, 98% coverage: 3:195/197 of query aligns to 2:194/194 of 5ekwA

query
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5ekwA

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binding [(2S)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]phosphonic acid: R91 (= R92), R113 (= R114), S191 (= S192), K193 (= K194)
binding [(2R)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]phosphonic acid: R91 (= R92), R113 (= R114), S191 (= S192), K193 (= K194)

4qnkA The structure of wt a. Thaliana igpd2 in complex with mn2+ and phosphate (see paper)
51% identity, 93% coverage: 3:185/197 of query aligns to 2:184/185 of 4qnkA

query
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4qnkA

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binding manganese (ii) ion: H39 (= H40), H65 (= H66), E69 (= E70), H137 (≠ E138), H161 (= H162), E165 (= E166)
binding phosphate ion: Q43 (= Q44), H47 (= H48), K169 (= K170)

4mu1A The structure of wt a. Thaliana igpd2 in complex with mn2+, imidazole, and sulfate at 1.5 a resolution (see paper)
51% identity, 93% coverage: 3:185/197 of query aligns to 2:184/185 of 4mu1A

query
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4mu1A

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binding imidazole: H65 (= H66), E69 (= E70)
binding manganese (ii) ion: H65 (= H66), E69 (= E70), H137 (≠ E138)

4mu0A The structure of wt a. Thaliana igpd2 in complex with mn2+ and 1,2,4- triazole at 1.3 a resolution (see paper)
51% identity, 93% coverage: 3:185/197 of query aligns to 2:184/185 of 4mu0A

query
sites
4mu0A

A

A

R

R

E

I

A

G

N

E

I

V

E

K

R

R

N

E

T

T

L

K

E

E

T

T

K

N

I

V

K

S

I

V

S

K

V

I

N

N

L

L

D

D

G

G

T

H

G

G

V

V

A

S

K

D

F

S

N

S

T

T

G

G

V

I

P

P

F

F

F

L

E

D

H

H

M

M

L

L

E

D

Q

Q

I

L

A

A

R

S

H

H

G

G

L

L

V

F

D

D

L

V

N

H

I

V

H

R

A

A

D

T

G

G

D

D

L

T

H

H

I

I

D

D

H
|
H

T

T

V

N

E
|
E

D

D

I

V

G

A

I

L

A

A

F

I

G

G

Q

T

A

A

V

L

L

L

N

K

A

A

V

L

G

G

D

E

K

R

R

K

G

G

I

I

V

N

R

R

Y

F

G

G

H

D

A

F

Y

T

V

A

P

P

L

L

D

D

E

E

A

A

L

L

S

I

L

H

V

V

V

S

I

L

D

D

L

L

S

S

G

G

R

R

P

P

G

Y

L

L

V

G

F

Y

N

N

A

L

N

E

F

I

N

P

R

T

E

Q

K

R

I

V

G

G

Q

T

F

Y

E

D

T

T

Q

Q

L

L

V

V

E

E

E
x
H

F

F

Q

Q

A

S

F

L

A

V

N

N

N

T

A

S

R

G

V

M

T

T

L

L

H

H

I

I

D

R

N

Q

L

L

Y

A

G

G

K

K

N

N

A

S

H

H

Q

I

V

I

E

E

T

A

I

T

F

F

K

K

A

A

F

F

G

A

R

R

A

A

L

L

R

R

M

Q

A

A

L

T

S

E

A

S

D

D

D

P

R

R

binding manganese (ii) ion: H65 (= H66), E69 (= E70), H137 (≠ E138)
binding 1,2,4-triazole: H65 (= H66), H66 (= H67)

8qavA Medicago truncatula hisn5 (igpd) in complex with mn and ig2 (see paper)
51% identity, 93% coverage: 3:185/197 of query aligns to 1:183/184 of 8qavA

query
sites
8qavA

A

A

R

R

E

I

A

G

N

E

I

M

E

K

R

R

N

V

T

T

L

K

E

E

T

T

K

N

I

V

K

S

I

V

S

K

V

I

N

N

L

L

D

D

G

G

T

T

G

G

V

V

A

A

K

D

F

N

N

S

T

S

G

G

V

I

P

P

F

F

F

L

E

D

H
|
H

M

M

L

L

E

D

Q

Q

I

L

A

A

R

S

H

H

G

G

L

L

V

F

D

D

L

V

N

H

I

V

H

K

A

A

D

T

G

G

D

D

L

T

H

H

I

I

D

D

H
|
H

T

T

V

N

E
|
E

D

D

I

V

G

A

I

L

A

A

F

I

G

G

Q

T

A

A

V

L

L

L

N

Q

A

A

V

L

G

G

D

D

K

R

R

K

G

G

I

I

V

N

R

R

Y

F

G

G

H

N

A

F

Y

S

V

A

P

P

L

L

D

D

E

E

A

A

L

L

S

V

L

H

V

V

V

S

I

L

D

D

L

L

S

S

G

G

R

R

P

P

G

H

L

L

V

G

F

Y

N

D

A

L

N

N

F

I

N

P

R

T

E

Q

K

R

I

V

G

G

Q

K

F

Y

E

D

T

T

Q

Q

L

L

V

V

E

E

E
x
H

F

F

Q

Q

A

S

F

L

A

V

N

N

N

T

A

S

R

G

V

M

T

T

L

L

H

H

I

I

D

R

N

Q

L

F

Y

S

G

G

K

T

N

N

A

S

H
|
H

H

H

Q

I

V

I

E
|
E

T

A

I

T

F

F

K

K

A

A

F

F

G

A

R

R

A

A

L

L

R

R

M

Q

A

A

L

T

S

E

A

Y

D

D

D

T

R

R

binding (2S,3S)-2,3-dihydroxy-3-(1H-imidazol-5-yl)propyl dihydrogen phosphate: H64 (= H66), H65 (= H67)
binding manganese (ii) ion: H38 (= H40), H64 (= H66), E68 (= E70), H136 (≠ E138), H160 (= H162), E164 (= E166)

8qawA Medicago truncatula hisn5 (igpd) in complex with mn, imd, edo, fmt, gol and trs (see paper)
51% identity, 93% coverage: 3:185/197 of query aligns to 2:184/185 of 8qawA

query
sites
8qawA

A

A

R

R

E

I

A

G

N

E

I

M

E

K

R

R

N

V

T

T

L

K

E
|
E

T

T

K

N

I

V

K

S

I

V

S

K

V

I

N

N

L

L

D

D

G

G

T

T

G

G

V

V

A

A

K

D

F

N

N

S

T

S

G

G

V

I

P

P

F

F

F

L

E

D

H
|
H

M

M

L

L

E

D

Q
|
Q

I

L

A

A

R

S

H
|
H

G

G

L

L

V

F

D

D

L

V

N

H

I

V

H

K

A

A

D

T

G

G

D

D

L

T

H

H

I

I

D

D

H
|
H

T

T

V

N

E
|
E

D

D

I

V

G

A

I

L

A

A

F

I

G

G

Q

T

A

A

V

L

L

L

N

Q

A

A

V

L

G

G

D

D

K

R

R

K

G

G

I

I

V

N

R

R

Y

F

G

G

H

N

A

F

Y

S

V

A

P

P

L

L

D

D

E

E

A

A

L

L

S

V

L

H

V

V

V

S

I

L

D

D

L

L

S

S

G

G

R

R

P

P

G

H

L

L

V

G

F

Y

N

D

A

L

N

N

F

I

N

P

R

T

E

Q

K

R

I

V

G

G

Q

K

F

Y

E

D

T

T

Q

Q

L

L

V

V

E

E

E
x
H

F

F

Q

Q

A

S

F

L

A

V

N

N

N

T

A

S

R

G

V

M

T

T

L

L

H

H

I

I

D

R

N

Q

L

F

Y

S

G

G

K

T

N

N

A

S

H
|
H

H

H

Q

I

V

I

E
|
E

T

A

I

T

F

F

K
|
K

A

A

F

F

G

A

R

R

A

A

L

L

R

R

M

Q

A

A

L

T

S

E

A

Y

D

D

D

T

R

R

binding glycerol: Q43 (= Q44), H47 (= H48), K169 (= K170)
binding imidazole: E13 (= E14), H66 (= H67), E69 (= E70)
binding manganese (ii) ion: H39 (= H40), H65 (= H66), E69 (= E70), H137 (≠ E138), H161 (= H162), E165 (= E166)

2f1dA X-ray structure of imidazoleglycerol-phosphate dehydratase (see paper)
51% identity, 93% coverage: 3:185/197 of query aligns to 1:183/183 of 2f1dA

query
sites
2f1dA

A

G

R

R

E

I

A

G

N

E

I

V

E

K

R

R

N

V

T

T

L

K

E

E

T

T

K

N

I

V

K

S

I

V

S

K

V

I

N

N

L

L

D

D

G

G

T

T

G

G

V

V

A

A

K

D

F

S

N

S

T

S

G

G

V

I

P

P

F

F

F

L

E

D

H
|
H

M

M

L

L

E

D

Q

Q

I

L

A

A

R

S

H

H

G

G

L

L

V

F

D

D

L

V

N

H

I

V

H

R

A

A

D

T

G

G

D

D

L

V

H

H

I

I

D

D

H
|
H

H

H

T

T

V

N

E
|
E

D

D

I

I

G

A

I

L

A

A

F

I

G

G

Q

T

A

A

V

L

L

L

N

K

A

A

V

L

G

G

D

E

K

R

R

K

G

G

I

I

V

N

R

R

Y

F

G

G

H

D

A

F

Y

T

V

A

P

P

L

L

D

D

E

E

A

A

L

L

S

I

L

H

V

V

V

S

I

L

D

D

L

L

S

S

G

G

R

R

P

P

G

Y

L

L

V

G

F

Y

N

N

A

L

N

E

F

I

N

P

R

T

E

Q

K

R

I

V

G

G

Q

T

F

Y

E

D

T

T

Q

Q

L

L

V

V

E

E

E
x
H

F

F

Q

Q

A

S

F

L

A

V

N

N

N

T

A

S

R

G

V

M

T

T

L

L

H

H

I

I

D

R

N

Q

L

L

Y

A

G

G

K

E

N

N

A

S

H
|
H

H

H

Q

I

V

I

E
|
E

T

A

I

T

F

F

K

K

A

A

F

F

G

A

R

R

A

A

L

L

R

R

M

Q

A

A

L

T

S

E

A

T

D

D

D

P

R

R

binding manganese (ii) ion: H38 (= H40), H64 (= H66), E68 (= E70), H136 (≠ E138), H160 (= H162), E164 (= E166)

4mu3A The form a structure of an e21q catalytic mutant of a. Thaliana igpd2 in complex with mn2+ and a mixture of its substrate, 2r3s-igp, and an inhibitor, 2s3s-igp, to 1.12 a resolution (see paper)
51% identity, 93% coverage: 3:185/197 of query aligns to 2:184/186 of 4mu3A

query
sites
4mu3A

A

A

R

R

E

I

A

G

N

E

I

V

E

K

R

R

N

E

T

T

L

K

E
x
Q

T

T

K

N

I

V

K

S

I

V

S

K

V

I

N

N

L

L

D

D

G

G

T

H

G

G

V

V

A

S

K

D

F

S

N

S

T

T

G

G

V

I

P

P

F

F

F

L

E

D

H

H

M

M

L

L

E

D

Q

Q

I

L

A

A

R

S

H

H

G

G

L

L

V

F

D

D

L

V

N

H

I

V

H

R

A

A

D

T

G

G

D

D

L

T

H

H

I

I

D

D

H
|
H

T

T

V

N

E
|
E

D

D

I

V

G

A

I

L

A

A

F

I

G

G

Q

T

A

A

V

L

L

L

N

K

A

A

V

L

G

G

D

E

K

R

R

K

G

G

I

I

V

N

R

R

Y

F

G

G

H

D

A

F

Y

T

V

A

P

P

L

L

D

D

E

E

A

A

L

L

S

I

L

H

V

V

V

S

I

L

D

D

L

L

S

S

G

G

R

R

P

P

G

Y

L

L

V

G

F

Y

N

N

A

L

N

E

F

I

N

P

R

T

E

Q

K

R

I

V

G

G

Q

T

F

Y

E

D

T

T

Q

Q

L

L

V

V

E

E

E
x
H

F

F

Q

Q

A

S

F

L

A

V

N

N

N

T

A

S

R

G

V

M

T

T

L

L

H

H

I

I

D

R

N

Q

L

L

Y

A

G

G

K

K

N

N

A

S

H

H

Q

I

V

I

E

E

T

A

I

T

F

F

K

K

A

A

F

F

G

A

R

R

A

A

L

L

R

R

M

Q

A

A

L

T

S

E

A

S

D

D

D

P

R

R

binding (2S,3S)-2,3-dihydroxy-3-(1H-imidazol-5-yl)propyl dihydrogen phosphate: H65 (= H66), H66 (= H67)
binding (2R,3S)-2,3-dihydroxy-3-(1H-imidazol-5-yl)propyl dihydrogen phosphate: Q13 (≠ E14), H65 (= H66), H66 (= H67)
binding manganese (ii) ion: H65 (= H66), E69 (= E70), H137 (≠ E138)

6fwhL Acanthamoeba igpd in complex with r-c348 to 1.7a resolution (see paper)
48% identity, 98% coverage: 4:197/197 of query aligns to 2:194/195 of 6fwhL

query
sites
6fwhL

R

R

E

E

A

A

N
x
Q

I

V

E

A

R

R

N

E

T

T

L

G

E
|
E

T

T

K

K

I

I

K

E

I

V

S

R

V

L

N

S

L

L

D

D

G

G

T

T

G

G

V

V

A

S

K

D

F

V

N

K

T

T

G

G

V

I

P

G

F

F

F

L

E

D

H
|
H

M

M

L

L

E

S

Q

A

I

L

A

A

R

K

H

H

G

G

L

R

V

F

D

D

L

L

N

Y

I

L

H

R

A

C

D

A

G

G

D

D

L

L

H

H

I

V

D

D

H
|
H

T

T

V

S

E
|
E

D

D

I

C

G

A

I

I

A

V

F

L

G

G

Q

Q

A

A

V

F

L

R

N
x
Q

A

A

V

I

G

G

D

E

K

R

R

K

G

G

I

I

V

K

R
|
R

Y

Y

G

G

H

S

A

A

Y

Y

V

A

P

P

L

L

D

D

E

E

A

S

L

L

S

A

L

R

V

A

V

V

I

V

D

D

L

I

S

S

G

S

R
|
R

P

P

G

F

L

A

V

V

F

I

N

D

A

L

N

K

F

L

N

K

R

R

E

E

K

K

I

I

G

G

Q

E

F

L

E

S

T

C

Q

E

L

M

V

I

E

P

E
x
H

F

V

F

L

Q

H

A

S

F

F

A

A

N

T

N

S

A

A

R

N

V

L

T

T

L

L

H

H

I

V

D

E

N

V

L

L

Y

Y

G

G

K

A

N

N

A

D

H
|
H

Q

K

V

A

E
|
E

T

S

I

A

F

F

K

K

A

A

F

T

G

A

R

L

A

A

L

L

R

R

M

E

A

A

L

V

S

T

A

K

D

D

D

G

R

-

M

P

Q

A

N

D

Q

A

L

V

P

P

S
|
S

T

T

K
|
K

G

G

A

V

L

L

binding [(2R)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]phosphonic acid: E12 (= E14), H38 (= H40), H64 (= H66), H65 (= H67), E68 (= E70), R90 (= R92), R112 (= R114), H160 (= H162), H161 (= H163), E164 (= E166), S189 (= S192), K191 (= K194)
binding magnesium ion: Q5 (≠ N7), Q80 (≠ N82)
binding manganese (ii) ion: H38 (= H40), H64 (= H66), E68 (= E70), H136 (≠ E138), H160 (= H162), E164 (= E166)

6fwhA Acanthamoeba igpd in complex with r-c348 to 1.7a resolution (see paper)
48% identity, 98% coverage: 4:197/197 of query aligns to 3:195/196 of 6fwhA

query
sites
6fwhA

R

R

E

E

A

A

N

Q

I

V

E

A

R

R

N

E

T

T

L

G

E
|
E

T

T

K

K

I

I

K

E

I

V

S

R

V

L

N

S

L

L

D

D

G

G

T

T

G

G

V

V

A

S

K

D

F

V

N

K

T

T

G

G

V

I

P

G

F

F

F

L

E

D

H
|
H

M

M

L

L

E

S

Q

A

I

L

A

A

R

K

H

H

G

G

L

R

V

F

D

D

L

L

N

Y

I

L

H

R

A

C

D

A

G

G

D

D

L

L

H

H

I

V

D

D

H
|
H

T

T

V

S

E
|
E

D

D

I

C

G

A

I

I

A

V

F

L

G

G

Q

Q

A

A

V

F

L

R

N

Q

A

A

V

I

G

G

D

E

K

R

R

K

G

G

I

I

V

K

R
|
R

Y

Y

G

G

H

S

A

A

Y

Y

V

A

P

P

L

L

D

D

E

E

A

S

L

L

S

A

L

R

V

A

V

V

I

V

D

D

L

I

S

S

G

S

R
|
R

P

P

G

F

L

A

V

V

F

I

N

D

A

L

N

K

F

L

N

K

R

R

E

E

K

K

I

I

G

G

Q

E

F

L

E

S

T

C

Q

E

L

M

V

I

E

P

E
x
H

F

V

F

L

Q

H

A

S

F

F

A

A

N

T

N

S

A

A

R

N

V

L

T

T

L

L

H

H

I

V

D

E

N

V

L

L

Y

Y

G

G

K

A

N

N

A

D

H
|
H

Q

K

V

A

E
|
E

T

S

I

A

F

F

K

K

A

A

F

T

G

A

R

L

A

A

L

L

R

R

M

E

A

A

L

V

S

T

A

K

D

D

D

G

R

-

M

P

Q

A

N

D

Q

A

L

V

P

P

S
|
S

T

T

K
|
K

G

G

A

V

L

L

binding [(2R)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]phosphonic acid: E13 (= E14), H39 (= H40), H65 (= H66), H66 (= H67), E69 (= E70), R91 (= R92), R113 (= R114), H161 (= H162), H162 (= H163), E165 (= E166), S190 (= S192), K192 (= K194)
binding manganese (ii) ion: H39 (= H40), H65 (= H66), E69 (= E70), H137 (≠ E138), H161 (= H162), E165 (= E166)

Q9S5G5 Histidine biosynthesis bifunctional protein HisB; EC 3.1.3.15; EC 4.2.1.19 from Escherichia coli O157:H7 (see paper)
49% identity, 98% coverage: 4:197/197 of query aligns to 167:355/355 of Q9S5G5

query
sites
Q9S5G5

R

R

E

Y

A

A

N

H

I

V

E

V

R

R

N

N

T

T

L

K

E

E

T

T

K

Q

I

I

K

D

I

V

S

Q

V

V

N

W

L

L

D

D

G

R

T

E

G

G

V

G

A

S

K

K

F

I

N

N

T

T

G

G

V

V

P

G

F

F

E

D

H

H

M

M

L

L

E

D

Q

Q

I

I

A

A

R

T

H

H

G

G

L

G

V

F

D

R

L

M

N

E

I

I

H

N

A

V

D

K

G

G

D

D

L

L

H

Y

I

I

D

D

H

H

T

T

V

V

E

E

D

D

I

T

G

G

I

L

A

A

F

L

G

G

Q

E

A

A

V

L

L

K

N

I

A

A

V

L

G

G

D

D

K

K

R

R

G

G

I

I

V

C

R

R

Y

F

G

G

H

F

A

V

Y

-

V

L

P

P

L

M

D

D

E

E

A

C

L

L

S

A

L

R

V

C

V

A

I

L

D

D

L

I

S

S

G

G

R

R

P

P

G

H

L

L

V

E

F

Y

N

K

A

A

N

E

F

F

N

T

R

Y

E

Q

K

R

I

V

G

G

Q

D

F

L

E

S

T

T

Q

E

L

M

V

I

E

E

E

H

F

F

Q

R

A

S

F

L

A

S

N

Y

N

T

A

M

R

G

V

V

T

T

L

L

H

H

I

L

D

K

N

T

L

-

Y

K

G

G

K

K

N

N

A

D

H

H

Q

R

V

V

E

E

T

S

I

L

F

F

K

K

A

A

F

F

G

G

R

R

A

T

L

L

R

R

M

Q

A

A

L

I

S

R

A

V

D

E

D

G

R

-

M

-

Q

-

N

D

Q

T

L

L

P

P

S

S

T

S

K

K

G

G

A

V

L

L

Sites not aligning to the query:

1:166 Histidinol-phosphatase
9 binding Mg(2+)
11 binding Mg(2+)
17 E→A: Severe decrease in histidinol-phosphate phosphatase activity in presence of low magnesium concentration. At higher magnesium concentration (5mM), no effect on activity.
93 binding Zn(2+)
95 binding Zn(2+)
101 binding Zn(2+)
103 binding Zn(2+)
130 binding Mg(2+)

P06633 Imidazoleglycerol-phosphate dehydratase; IGPD; EC 4.2.1.19 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
41% identity, 100% coverage: 1:197/197 of query aligns to 1:219/220 of P06633

query
sites
P06633

M

M

V

T

A

E

R

Q

E

K

A

A

N

L

I

V

E

K

R

R

N

I

T

T

L

N

E

E

T

T

K

K

I

I

K

Q

I

I

S

A

V

I

N

S

L

L

D

K

G

G

-

G

-

P

-

L

-

A

-

I

-

E

-

H

-

S

-

I

-

F

-

P

-

E

-

K

-

E

-

A

-

E

-

A

-

V

-

A

-

E

-

Q

-

A

-

T

-

Q

T

S

G

Q

V

V

A

I

K

N

F

V

N

H

T

T

G

G

V

I

P

G

F

F

F

L

E

D

H
|
H

M
|
M

L
x
I

E
x
H

Q
x
A

I
x
L

A
|
A

R
x
K

H
|
H

G

S

L

G

V

W

D

S

L

L

N

I

I

V

H

E

A

C

D

I

G

G

D

D

L

L

H

H

I

I

D

D

H
|
H

T
|
T

V
x
T

E
|
E

D

D

I

C

G

G

I

I

A

A

F

L

G

G

Q

Q

A

A

V

F

L

K

N

E

A

A

V

L

G

G

D

A

K

V

R

R

G

G

I

V

V

K

R
|
R

Y

F

G

G

H

S

A

G

Y

F

V

A

P

P

L

L

D

D

E

E

A

A

L

L

S

S

L

R

V

A

V

V

I

V

D

D

L

L

S

S

G

N

R

R

P

P

G

Y

L

A

V

V

F

V

N

E

A

L

N

G

F

L

N

Q

R

R

E

E

K

K

I

V

G

G

Q

D

F

L

E

S

T

C

Q

E

L

M

V

I

E

P

E
x
H

F

F

F

L

Q

E

A

S

F

F

A

A

N

E

N

A

A

S

R

R

V

I

T

T

L

L

H

H

I

V

D

D

N

C

L

L

Y

R

G

G

K

K

N

N

A

D

H
|
H

Q
x
R

V
x
S

E
|
E

T
x
S

I
x
A

F
|
F

K
|
K

A

A

F

L

G

A

R

V

A

A

L

I

R

R

M

E

A

A

L

T

S

S

A

P

D

N

D

G

R

-

M

-

Q

T

N

N

Q

D

L

V

P

P

S
|
S

T
|
T

K
|
K

G

G

A

V

L

L

H64 (= H40) binding Mn(2+)
64:72 (vs. 40:48, 44% identical) binding substrate
H90 (= H66) binding Mn(2+)
HHTTE 90:94 (≠ HHTVE 66:70) binding substrate
H91 (= H67) binding Mn(2+)
E94 (= E70) binding Mn(2+)
R116 (= R92) binding substrate
H162 (≠ E138) binding Mn(2+)
H186 (= H162) binding Mn(2+)
186:194 (vs. 162:170, 56% identical) binding substrate
H187 (= H163) binding Mn(2+)
E190 (= E166) binding Mn(2+)
STK 214:216 (= STK 192:194) binding substrate

6ezmU Imidazoleglycerol-phosphate dehydratase from saccharomyces cerevisiae (see paper)
42% identity, 98% coverage: 4:197/197 of query aligns to 2:212/212 of 6ezmU

query
sites
6ezmU

R

Q

E

K

A

A

N

L

I

V

E

K

R

R

N

I

T

T

L

N

E

E

T

T

K

K

I

I

K

Q

I

I

S

A

V

I

N

S

L

L

D

K

G

G

-

G

-

P

-

L

-

A

-

I

-

E

-

H

-

S

-

I

-

F

-

P

-

E

-

K

-

A

-

E

-

Q

-

A

-

T

-

Q

T

S

G

Q

V

V

A

I

K

N

F

V

N

H

T

T

G

G

V

I

P

G

F

F

F

L

E

D

H
|
H

M

M

L

I

E

H

Q

A

I

L

A

A

R

K

H

H

G

S

L

G

V

W

D

S

L

L

N

I

I

V

H

E

A

C

D

I

G

G

D

D

L

L

H

H

I

I

D

D

H
|
H

T

T

V

T

E
|
E

D

D

I

C

G

G

I

I

A

A

F

L

G

G

Q

Q

A

A

V

F

L

K

N

E

A

A

V

L

G

G

D

A

K

V

R

R

G

G

I

V

V

K

R

R

Y

F

G

G

H

S

A

G

Y

F

V

A

P

P

L

L

D

D

E

E

A

A

L

L

S

S

L

R

V

A

V

V

I

V

D

D

L

L

S

S

G

N

R

R

P

P

G

Y

L

A

V

V

F

V

N

E

A

L

N

G

F

L

N

Q

R

R

E

E

K

K

I

V

G

G

Q

D

F

L

E

S

T

C

Q

E

L

M

V

I

E

P

E
x
H

F

F

F

L

Q

E

A

S

F

F

A

A

N

E

N

A

A

S

R

R

V

I

T

T

L

L

H

H

I

V

D

D

N

C

L

L

Y

R

G

G

K

K

N

N

A

D

H
|
H

Q

R

V

S

E
|
E

T

S

I

A

F

F

K
|
K

A

A

F

L

G

A

R

V

A

A

L

I

R

R

M

E

A

A

L

T

S

S

A

P

D

N

D

G

R

-

M

-

Q

T

N

N

Q

D

L

V

P

P

S
|
S

T

T

K
|
K

G

G

A

V

L

L

binding [(2R)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]phosphonic acid: H57 (= H40), H83 (= H66), H84 (= H67), E87 (= E70), H179 (= H162), H180 (= H163), E183 (= E166), K187 (= K170), S207 (= S192), K209 (= K194)
binding manganese (ii) ion: H57 (= H40), H83 (= H66), E87 (= E70), H155 (≠ E138), H179 (= H162), E183 (= E166)

2ae8B Crystal structure of imidazoleglycerol-phosphate dehydratase from staphylococcus aureus subsp. Aureus n315
51% identity, 88% coverage: 9:182/197 of query aligns to 7:171/172 of 2ae8B

query
sites
2ae8B

E

Q

R

R

N

N

T

Q

L

L

E

N

T

I

K

S

I

I

K

S

I

-

S

-

V

-

N

-

L

-

D

D

G

D

T

Q

G

S

V

P

A

S

K

H

F

I

N

N

T

T

G

G

V

V

P

G

F

F

F

L

E

N

H
|
H

M

M

L

L

E

T

Q

L

I

F

A

T

R

F

H

H

G

S

L

G

V

L

D

S

L

L

N

N

I

I

H

E

A

A

D

Q

G

G

D

D

L

-

H

-

I

-

D

-

D

D

H
|
H

H

H

T

V

V

T

E
|
E

D

D

I

I

G

G

I

I

A

V

F

I

G

G

Q

Q

A

L

V

L

L

L

N

E

A

M

V

I

G

K

D

D

K

K

R

K

G

H

I

F

V

V

R

R

Y

Y

G

G

H

T

A

M

Y

Y

V

I

P

P

L

M

D

D

E

E

A

T

L

L

S

A

L

R

V

V

I

V

D

D

L

I

S

S

G

G

R

R

P

P

G

Y

L

L

V

S

F

F

N

N

A

A

N

S

F

L

N

S

R

K

E

E

K

K

I

V

G

G

Q

T

F

F

E

D

T

T

Q

E

L

L

V

V

E

E

F

F

Q

R

A

A

F

V

A

V

N

I

N

N

A

A

R

R

V

L

T

T

L

T

H

H

I

I

D

D

N

L

L

I

Y

R

G

G

K

G

N

N

A

T

H
|
H

H

H

Q

E

V

I

E
|
E

T

A

I

I

F

F

K

K

A

A

F

F

G

S

R

R

A

A

L

L

R

G

M

I

A

A

L

L

S

T

A

A

binding magnesium ion: H33 (= H40), H55 (= H66), E59 (= E70), H151 (= H162), E155 (= E166)

P40374 Imidazoleglycerol-phosphate dehydratase; IGPD; EC 4.2.1.19 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
41% identity, 98% coverage: 4:197/197 of query aligns to 2:216/216 of P40374

query
sites
P40374

R

R

E

R

A

A

N

F

I

V

E

E

R

R

N

N

T

T

L

N

E

E

T

T

K

K

I

I

K

S

I

V

S

A

V

I

N

A

L

L

D

D

-

K

-

A

-

P

-

L

-

P

-

E

-

S

-

N

-

F

-

I

-

D

-

E

-

L

-

I

-

T

-

S

-

K

-

H

-

A

-

N

-

Q

-

K

G

G

T

E

G

Q

V

V

A

I

K

Q

F

V

N

D

T

T

G

G

V

I

P

G

F

F

F

L

E

D

H

H

M

M

L

Y

E

H

Q

A

I

L

A

A

R

K

H

H

G

A

L

G

V

W

D

S

L

L

N

R

I

L

H

Y

A

S

D

R

G

G

D

D

L

L

H

I

I

I

D

D

H

H

T

T

V

A

E

E

D

D

I

T

G

A

I

I

A

A

F

L

G

G

Q

I

A

A

V

F

L

K

N

Q

A

A

V

M

G

G

D

N

K

F

R

A

G

G

I

V

V

K

R

R

Y

F

G

G

H

H

A

A

Y

Y

V

C

P

P

L

L

D

D

E

E

A

A

L

L

S

S

L

R

V

S

V

V

I

V

D

D

L

L

S

S

G

G

R

R

P

P

G

Y

L

A

V

V

F

I

N

D

A

L

N

G

F

L

N

K

R

R

E

E

K

K

I

V

G

G

Q

E

F

L

E

S

T

C

Q

E

L

M

V

I

E

P

E

H

F

L

Q

Y

A

S

F

F

A

S

N

V

N

A

A

A

R

G

V

I

T

T

L

L

H

H

I

V

D

T

N

C

L

L

Y

Y

G

G

K

S

N

N

A

D

H

H

Q

R

V

A

E

E

T

S

I

A

F

F

K

K

A

S

F

L

G

A

R

V

A

A

L

M

R

R

M

A

A

A

L

T

S

S

A

L

D

T

D

G

R

-

M

-

Q

S

N

S

Q

E

L

V

P

P

S
|
S

T

T

K

K

G

G

A

V

L

L

S211 (= S192) modified: Phosphoserine

P9WML9 Imidazoleglycerol-phosphate dehydratase; IGPD; EC 4.2.1.19 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
44% identity, 93% coverage: 14:197/197 of query aligns to 21:210/210 of P9WML9

query
sites
P9WML9

E

E

T

S

K

D

I

I

K

V

I

I

S

E

V

L

N

D

L

L

D

D

G

G

T

T

G

G

V

Q

A

V

K

A

F

V

N

D

T

T

G

G

V

V

P

P

F

F

F

Y

E

D

H
|
H

M
|
M

L
|
L

E
x
T

Q
x
A

I
x
L

A
x
G

R
x
S

H
|
H

G

A

L

S

V

F

D

D

L

L

N

T

I

V

H

R

A

A

D

T

G

G

D

D

L

V

H

E

I

I

D

E

D

A

H
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H

T
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T

V
x
I

E
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E

D

D

I

T

G

A

I

I

A

A

F

L

G

G

Q

T

A

A

V

L

L

G

N

Q

A

A

V

L

G

G

D

D

K

K

R

R

G

G

I

I

V

R

R

R

Y

F

G

G

H

D

A

A

Y

F

V

I

P

P

L

M

D

D

E

E

A

T

L

L

S

A

L

H

V

A

I

V

D

D

L

L

S

S

G

G

R

R

P

P

G

Y

L

C

V

V

F

H

N

T

A

G

-

E

-

P

-

D

N

H

F

L

N

Q

R

H

E

T

K

T

I

I

G

A

-

G

-

S

-

V

Q

P

F

Y

E

H

T

T

Q

V

L

I

V

N

E

R

E
x
H

F

V

F

F

Q

E

A

S

F

L

A

A

N

A

N

N

A

A

R

R

V

I

T

A

L

L

H

H

I

V

D

R

N

V

L

L

Y

Y

G

G

K

R

N

D

A

P

H
|
H

Q
x
I

V
x
T

E
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E

T
x
A

I
x
Q

F
x
Y

K
|
K

A

A

F

V

G

A

R

R

A

A

L

L

R

R

M

Q

A

A

L

V

S

E

A

P

D

D

D

P

R

R

M

V

Q

S

N

G

Q

-

L

V

P

P

S

S

T

T

K

K

G

G

A

A

L

L

H47 (= H40) binding Mn(2+)
47:55 (vs. 40:48, 44% identical) binding substrate
H73 (= H66) binding Mn(2+)
HHTIE 73:77 (≠ HHTVE 66:70) binding substrate
H74 (= H67) binding Mn(2+)
E77 (= E70) binding Mn(2+)
H152 (≠ E138) binding Mn(2+)
H176 (= H162) binding Mn(2+)
176:184 (vs. 162:170, 44% identical) binding substrate
H177 (= H163) binding Mn(2+)
E180 (= E166) binding Mn(2+)

1rhyB Crystal structure of imidazole glycerol phosphate dehydratase (see paper)
44% identity, 90% coverage: 4:181/197 of query aligns to 3:178/180 of 1rhyB

query
sites
1rhyB

R

R

E

I

A

A

N

S

I

V

E

E

R

R

N

T

T

T

L

S

E

E

T

T

K

H

I

I

K

S

I

C

S

T

V

I

N

D

L

L

D

D

-

H

-

I

-

P

G

G

T

V

G

T

V

E

A

Q

K

K

F

I

N

N

-

V

-

S

T

T

G

G

V

I

P

G

F

F

F

L

E

D

H

H

M

M

L

F

E

T

Q

A

I

L

A

A

R

K

H

H

G

G

L

G

V

M

D

S

L

L

N

Q

I

L

H

Q

A

C

D

K

G

G

D

D

L

-

H

-

I

-

D

-

H

-

T

T

V

A

E

E

D

D

I

C

G

A

I

L

A

A

F

L

G

G

Q

E

A

A

V

F

L

K

N

K

A

A

V

L

G

G

D

E

K

R

R

K

G

G

I

I

V

K

R

R

Y

Y

G

G

H

Y

A

A

Y

Y

V

A

P

P

L

L

D

D

E

E

A

S

L

L

S

S

L

R

V

A

V

V

I

I

D

D

L

I

S

S

G

S

R

R

P

P

G

Y

L

F

V

M

F

C

N

H

A

L

N

P

F

F

N

T

R

R

E

E

K

K

I

V

G
|
G

Q

D

F

L

E

S

T

T

Q

E

L

M

V

V

E

S

E

H

F

L

Q

Q

A

S

F

F

A

A

N

F

N

A

A

A

R

G

V

V

T

T

L

L

H

H

I

I

D

D

N

S

L

I

Y

R

G

G

K

E

N

N

A

N

H
|
H

H

H

Q

I

V

A

E

E

T

S

I

A

F

F

K

K

A

A

F

L

G

A

R

L

A

A

L

I

R

R

M

M

A

A

L

I

S

S

binding glycerol: G126 (= G129), H159 (= H162)

Query Sequence

>WP_013836069.1 NCBI__GCF_000214825.1:WP_013836069.1
MVAREANIERNTLETKIKISVNLDGTGVAKFNTGVPFFEHMLEQIARHGLVDLNIHADGD
LHIDDHHTVEDIGIAFGQAVLNAVGDKRGIVRYGHAYVPLDEALSLVVIDLSGRPGLVFN
ANFNREKIGQFETQLVEEFFQAFANNARVTLHIDNLYGKNAHHQVETIFKAFGRALRMAL
SADDRMQNQLPSTKGAL

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory