Comparing WP_013840110.1 NCBI__GCF_000215085.1:WP_013840110.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
3dc2A Crystal structure of serine bound d-3-phosphoglycerate dehydrogenase from mycobacterium tuberculosis (see paper)
41% identity, 96% coverage: 3:505/526 of query aligns to 4:504/526 of 3dc2A
3ddnB Crystal structure of hydroxypyruvic acid phosphate bound d-3- phosphoglycerate dehydrogenase in mycobacterium tuberculosis (see paper)
41% identity, 96% coverage: 3:505/526 of query aligns to 5:503/525 of 3ddnB
O43175 D-3-phosphoglycerate dehydrogenase; 3-PGDH; 2-oxoglutarate reductase; Malate dehydrogenase; EC 1.1.1.95; EC 1.1.1.399; EC 1.1.1.37 from Homo sapiens (Human) (see 3 papers)
40% identity, 84% coverage: 2:443/526 of query aligns to 8:450/533 of O43175
Sites not aligning to the query:
6plfA Crystal structure of human phgdh complexed with compound 1 (see paper)
48% identity, 58% coverage: 2:304/526 of query aligns to 4:305/305 of 6plfA
7dkmA Phgdh covalently linked to oridonin (see paper)
48% identity, 58% coverage: 2:308/526 of query aligns to 4:304/306 of 7dkmA
6cwaA Crystal structure phgdh in complex with nadh and 3-phosphoglycerate at 1.77 a resolution (see paper)
48% identity, 57% coverage: 2:299/526 of query aligns to 2:298/299 of 6cwaA
6rj5A Crystal structure of phgdh in complex with compound 39 (see paper)
48% identity, 57% coverage: 2:299/526 of query aligns to 3:299/301 of 6rj5A
6plgA Crystal structure of human phgdh complexed with compound 15 (see paper)
48% identity, 58% coverage: 2:308/526 of query aligns to 3:303/303 of 6plgA
7ewhA Crystal structure of human phgdh in complex with homoharringtonine (see paper)
48% identity, 57% coverage: 2:299/526 of query aligns to 3:299/302 of 7ewhA
6rihA Crystal structure of phgdh in complex with compound 9 (see paper)
48% identity, 57% coverage: 2:299/526 of query aligns to 3:299/302 of 6rihA
6rj3A Crystal structure of phgdh in complex with compound 15 (see paper)
49% identity, 56% coverage: 2:295/526 of query aligns to 2:294/297 of 6rj3A
6rj2A Crystal structure of phgdh in complex with compound 40 (see paper)
50% identity, 53% coverage: 19:299/526 of query aligns to 16:296/299 of 6rj2A
6plfB Crystal structure of human phgdh complexed with compound 1 (see paper)
50% identity, 50% coverage: 36:299/526 of query aligns to 31:290/292 of 6plfB
1wwkA Crystal structure of phosphoglycerate dehydrogenase from pyrococcus horikoshii ot3
48% identity, 58% coverage: 1:304/526 of query aligns to 1:304/304 of 1wwkA
7cvpA The crystal structure of human phgdh from biortus.
46% identity, 49% coverage: 44:299/526 of query aligns to 23:253/254 of 7cvpA
P87228 Putative D-3-phosphoglycerate dehydrogenase; 3-PGDH; 2-oxoglutarate reductase; EC 1.1.1.95; EC 1.1.1.399 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
36% identity, 61% coverage: 1:323/526 of query aligns to 56:389/466 of P87228
5ofwA Crystal structure of human 3-phosphoglycerate dehydrogenase in complex with 3-chloro-4-fluorobenzamide (see paper)
49% identity, 37% coverage: 95:287/526 of query aligns to 1:193/195 of 5ofwA
5ofvA Crystal structure of human 3-phosphoglycerate dehydrogenase in complex with 5-fluoro-2-methylbenzoic acid (see paper)
49% identity, 37% coverage: 95:287/526 of query aligns to 1:193/195 of 5ofvA
5ofmA Crystal structure of human 3-phosphoglycerate dehydrogenase in complex with 5-amino-1-methyl-1h-indole
49% identity, 37% coverage: 95:287/526 of query aligns to 1:193/195 of 5ofmA
5nzqA Crystal structure of human 3-phosphoglycerate dehydrogenase in complex with 3-(1,3-oxazol-5-yl)aniline. (see paper)
49% identity, 37% coverage: 95:287/526 of query aligns to 1:193/195 of 5nzqA
>WP_013840110.1 NCBI__GCF_000215085.1:WP_013840110.1
MKVLVMDGVAEKGLAPLRQQPDIEVVIGNKMTEDELVAVIGQYDGLIVRSATKVTARVIE
AATRLKVIGRAGVGVDNIDRNAATNKGILVVNAPDGNTIAAAELTMAMMLSLARKVPMAC
SKLKSGCWDKKAFMGMELRGKTLGVIGLGRIGSAVAKRAQAMEMHIVAYDPYISEEHAQK
MAVELLSLDKVFEQADIITIHMPKTKETYHMINKEALEKMKEGVRIINCARGGIVDEPAL
YEYMVNGKVAGAALDVFEVEPCTENPLLQLENFIATPHLGASTEEAQINVAVDVAEEIVA
ALRGDLVKNAVNIPSMSPKLLAKVRPFLDLAEKLGKFQAQMLNGRLEKVEVVYSGELARY
DVNPITTLLLKGLLDPILQENVNFVNAPVVARNRGITVVQTTTDNAEDYNNLITVAVYTN
NGKRLLSGALFQGNDPRIVNIDGYRINAATSGHMLVVPHIDKPRIVGKVGTVVGDKDINI
AGMQVGRIELGGKAIMVMMVDNIVPQCAMDELAKIDGVLEVKMVSL
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory