SitesBLAST – Find functional sites

 

SitesBLAST

Comparing WP_014025668.1 NCBI__GCF_000223395.1:WP_014025668.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 6 hits to proteins with known functional sites (download)

6hqvA Pentafunctional arom complex from chaetomium thermophilum (see paper)
31% identity, 21% coverage: 350:446/459 of query aligns to 727:826/1555 of 6hqvA

query
sites
6hqvA
S
 
T
V
 
T
K
 
Q
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I
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T
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G
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I
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A
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W
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W
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I
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L
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Q

Sites not aligning to the query:

P11043 3-phosphoshikimate 1-carboxyvinyltransferase, chloroplastic; 5-enolpyruvylshikimate-3-phosphate synthase; EPSP synthase; EC 2.5.1.19 from Petunia hybrida (Petunia) (see paper)
30% identity, 26% coverage: 326:446/459 of query aligns to 394:512/516 of P11043

query
sites
P11043
I
 
I
T
 
D
I
 
V
T
 
N
V
 
M
R
 
N
R
 
K
E
 
M
P
 
P
D
 
D
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V
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A
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M
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T
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L
A
 
A
Y
 
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A
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L
A
 
Y
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A
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D
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A
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I
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K
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A
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I
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C
A
 
T
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E
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L
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K
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L
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G
Y
 
A
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T
A
 
V
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E
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E
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N
 
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D
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Y
I
 
C
I
 
I
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I
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T
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-
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K
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L
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N
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I
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D
C
 
T
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Y
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D
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D
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H
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R
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A
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M
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A
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F
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-
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A
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A
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C
S
 
A
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D
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P
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N
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A
 
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C
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N
F
 
Y
W
 
F
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D
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V
L
 
L
Q
 
Q
E
 
Q

Sites not aligning to the query:

P07547 Pentafunctional AROM polypeptide; EC 4.2.3.4; EC 2.5.1.19; EC 2.7.1.71; EC 4.2.1.10; EC 1.1.1.25 from Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) (see 2 papers)
26% identity, 21% coverage: 350:446/459 of query aligns to 739:838/1583 of P07547

query
sites
P07547
S
 
T
V
 
T
K
 
R
I
 
I
A
 
Y
G
 
G
V
 
I
H
 
A
H
 
N
L
 
Q
V
 
R
L
 
V
K
 
K
E
 
E
S
 
C
N
 
N
R
 
R
L
 
I
E
 
K
S
 
A
V
 
M
T
 
K
A
 
D
S
 
E
L
 
L
R
 
A
S
 
K
L
 
F
G
 
G
Y
 
V
V
 
I
A
 
C
Y
 
R
H
 
E
T
 
H
N
 
D
D
 
D
D
 
G
I
 
L
I
 
E
V
 
I
A
 
D
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G
-
 
I
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D
-
 
R
R
 
S
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N
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L
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R
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Q
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P
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G
N
 
G
I
 
V
E
 
F
C
 
C
P
 
Y
D
 
D
D
 
D
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H
R
 
R
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A
 
A
M
 
F
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S
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F
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S
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V
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L
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A
 
L
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P
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I
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L
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E
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P
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G
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W
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W
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D
T
 
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L
Q
 
R
E
 
Q

Sites not aligning to the query:

Q83E11 3-phosphoshikimate 1-carboxyvinyltransferase; 5-enolpyruvylshikimate-3-phosphate synthase; EPSP synthase; EPSPS; EC 2.5.1.19 from Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
26% identity, 43% coverage: 255:451/459 of query aligns to 231:429/438 of Q83E11

query
sites
Q83E11
P
 
P
G
 
G
D
 
D
W
 
I
G
 
S
L
 
S
A
 
A
S
 
A
L
 
F
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F
A
 
I
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V
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A
A
 
A
S
 
T
T
 
I
G
 
T
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P
R
 
G
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S
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A
I
 
I
R
 
R
G
 
-
L
 
L
W
 
C
R
 
R
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V
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G
A
 
V
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N
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P
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L
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I
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N
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A
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I
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K
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L
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G
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I
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A
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A
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E
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D
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I
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I
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G
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L
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E
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G
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N
I
 
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E
 
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Y
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D
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I
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A
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M
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A
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F
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A
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A
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G
A
 
T
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L
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A
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K
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G
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P
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I
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R
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N
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C
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D
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N
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T
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S
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F
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P
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N
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E
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L
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A
Q
 
N
E
 
E
A
 
V
G
 
G
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M
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N
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V

Sites not aligning to the query:

3slhD 1.70 angstrom resolution structure of 3-phosphoshikimate 1- carboxyvinyltransferase (aroa) from coxiella burnetii in complex with shikimate-3-phosphate and glyphosate
27% identity, 34% coverage: 296:451/459 of query aligns to 273:431/440 of 3slhD

query
sites
3slhD
K
 
K
I
 
M
L
 
M
G
 
G
F
 
A
D
 
D
S
 
I
K
 
E
I
 
V
L
 
T
E
 
H
H
 
Y
D
 
T
D
 
E
S
 
K
A
 
N
E
 
E
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E
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P
I
 
T
E
 
A
P
 
D
F
 
I
S
 
T
A
 
V
R
 
R
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H
A
 
A
-
 
R
-
 
L
-
 
K
-
 
G
-
 
I
-
 
D
-
 
I
-
 
P
-
 
P
D
 
D
N
 
Q
I
 
V
T
 
P
I
 
L
T
 
T
V
 
I
R
x
D
R
 
E
E
 
F
P
 
P
D
 
-
V
 
-
A
 
-
V
 
V
S
 
L
V
 
L
A
 
I
Y
 
A
A
 
A
A
 
A
S
 
V
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A
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Q
G
 
G
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K
S
 
T
V
 
V
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-
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L
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A
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A
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E
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L
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I
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A
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A
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M
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G
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L
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K
L
 
L
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G
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I
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A
A
 
A
Y
 
E
H
 
S
T
 
L
N
 
P
D
 
D
D
 
G
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V
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I
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I
A
 
Q
G
 
G
R
 
G
A
 
T
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L
K
 
E
P
 
G
S
 
G
F
 
E
V
 
V
N
 
N
I
 
-
E
 
-
C
 
S
P
 
Y
D
 
D
D
 
D
H
|
H
R
|
R
I
 
I
A
 
A
M
 
M
G
 
A
T
 
F
A
 
A
V
 
V
L
 
A
A
 
G
A
 
T
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L
S
 
A
G
 
K
V
 
G
V
 
P
A
 
V
R
 
R
I
 
I
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R
N
 
N
A
 
C
T
 
D
C
 
N
T
 
V
S
 
K
K
x
T
S
 
S
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F
R
 
P
G
 
N
F
 
F
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V
S
 
E
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L
L
 
A
Q
 
N
E
 
E
A
 
V
G
 
G
V
 
M
R
 
N
I
 
V

Sites not aligning to the query:

4egrA 2.50 angstrom resolution structure of 3-phosphoshikimate 1- carboxyvinyltransferase (aroa) from coxiella burnetii in complex with phosphoenolpyruvate
26% identity, 43% coverage: 255:451/459 of query aligns to 231:427/434 of 4egrA

query
sites
4egrA
P
 
P
G
 
G
D
 
D
W
 
I
G
 
S
L
 
S
A
 
A
S
 
A
L
 
F
V
 
F
A
 
I
P
 
V
L
 
A
A
 
A
S
 
T
T
 
I
G
 
T
V
 
P
R
 
G
L
 
S
I
 
A
I
 
I
R
 
R
G
 
-
L
 
L
W
 
C
R
 
R
P
 
V
W
 
G
A
 
V
G
 
N
P
 
P
G
 
T
D
 
R
H
 
L
Y
 
G
A
 
V
S
 
I
F
 
N
Y
 
L
Y
 
L
K
 
K
I
 
M
L
 
M
G
 
G
F
 
A
D
 
D
S
 
I
K
 
E
I
 
V
L
 
T
E
 
H
H
 
Y
-
 
T
D
 
E
D
 
K
S
 
E
A
 
P
E
 
T
W
 
A
D
 
D
I
 
I
E
 
T
P
 
V
F
 
R
S
 
H
A
 
A
R
 
R
-
 
L
-
 
K
-
 
G
-
 
I
-
 
D
-
 
I
S
 
P
A
 
P
D
 
D
N
 
Q
I
 
V
T
 
P
I
 
L
T
 
T
V
 
I
R
x
D
R
 
E
E
 
F
P
 
P
D
 
V
V
 
L
A
 
L
V
 
I
S
 
A
V
 
-
A
 
-
Y
 
-
A
 
A
A
 
A
S
 
V
A
 
A
L
 
Q
G
 
G
V
 
K
S
 
T
V
 
V
K
 
-
I
 
L
A
 
R
G
 
D
V
 
A
H
 
A
H
 
E
L
 
L
V
 
R
L
 
V
K
 
K
E
|
E
S
 
T
N
 
D
R
|
R
L
 
I
E
 
A
S
 
A
V
 
M
T
 
V
A
 
D
S
 
G
L
 
L
R
 
Q
S
 
K
L
 
L
G
 
G
Y
 
I
V
 
A
A
 
A
Y
 
E
H
 
S
T
 
L
N
 
P
D
 
D
D
 
G
I
 
V
I
 
I
V
 
I
A
 
Q
G
 
G
R
 
G
A
 
T
V
 
L
K
 
E
P
 
G
S
 
G
F
 
E
V
 
V
N
 
N
I
 
-
E
 
-
C
 
S
P
 
Y
D
 
D
D
 
D
H
|
H
R
|
R
I
 
I
A
 
A
M
 
M
G
 
A
T
 
F
A
 
A
V
 
V
L
 
A
A
 
G
A
 
T
T
 
L
S
 
A
G
 
K
V
 
G
V
 
P
A
 
V
R
 
R
I
 
I
S
 
R
N
 
N
A
 
C
T
 
D
C
 
N
T
 
V
S
 
K
K
x
T
S
 
S
W
 
F
R
 
P
G
 
N
F
 
F
W
 
V
S
 
E
T
 
L
L
 
A
Q
 
N
E
 
E
A
 
V
G
 
G
V
 
M
R
 
N
I
 
V

Sites not aligning to the query:

Query Sequence

>WP_014025668.1 NCBI__GCF_000223395.1:WP_014025668.1
MPDSVMGRALVADPHVVVVTGFEPKSSVVEIKAPPSKSFYYRLAGLLLAGRGCVRNVPDC
EDADAATDIVLAAGGVVVSDGRVCLDYFRESETYDVDVYCSGGALRITLVALLAAAPIGS
RISVHVCKRLFRRLEEGTLSLWKQFGEARLDPGSNVINIVKTREPQMLRVASTKSSQPIS
GALIAAAILSALRGGDPVKVEGYTGVSSGHIYETLESLRLAGFTLEDIRIDERGDGIAIH
ALVSGVERRFVLWTPGDWGLASLVAPLASTGVRLIIRGLWRPWAGPGDHYASFYYKILGF
DSKILEHDDSAEWDIEPFSARSADNITITVRREPDVAVSVAYAASALGVSVKIAGVHHLV
LKESNRLESVTASLRSLGYVAYHTNDDIIVAGRAVKPSFVNIECPDDHRIAMGTAVLAAT
SGVVARISNATCTSKSWRGFWSTLQEAGVRIFFEGGKLE

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory