SitesBLAST
Comparing WP_014450383.1 NCBI__GCF_000284315.1:WP_014450383.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
1sb9A Crystal structure of pseudomonas aeruginosa udp-n-acetylglucosamine 4- epimerase complexed with udp-glucose (see paper)
44% identity, 97% coverage: 7:310/314 of query aligns to 19:335/340 of 1sb9A
- active site: S141 (= S121), S142 (= S122), S143 (= S123), Y165 (= Y145), K169 (= K149), N203 (≠ Q183)
- binding nicotinamide-adenine-dinucleotide: G22 (= G10), G25 (= G13), F26 (= F14), I27 (= I15), D46 (= D34), N47 (= N35), F48 (≠ L36), T50 (= T38), G51 (= G39), D77 (= D57), I78 (≠ V58), Q97 (= Q77), A99 (= A79), T116 (≠ A96), A139 (= A119), A140 (≠ G120), Y165 (= Y145), K169 (= K149), Y192 (= Y172), N194 (= N174), V195 (≠ I175)
- binding uridine-5'-diphosphate-glucose: S141 (= S121), Y165 (= Y145), N194 (= N174), A208 (= A188), V209 (= V189), W213 (≠ F193), Y224 (≠ T204), I225 (= I205), N226 (≠ Y206), L270 (= L249), R298 (= R273), D301 (= D276)
1sb8A Crystal structure of pseudomonas aeruginosa udp-n-acetylglucosamine 4- epimerase complexed with udp-n-acetylgalactosamine (see paper)
44% identity, 97% coverage: 7:310/314 of query aligns to 20:336/341 of 1sb8A
- active site: S142 (= S121), S143 (= S122), S144 (= S123), Y166 (= Y145), K170 (= K149), N204 (≠ Q183)
- binding nicotinamide-adenine-dinucleotide: G23 (= G10), G26 (= G13), F27 (= F14), I28 (= I15), D47 (= D34), N48 (= N35), F49 (≠ L36), T51 (= T38), G52 (= G39), D78 (= D57), I79 (≠ V58), Q98 (= Q77), A100 (= A79), T117 (≠ A96), A140 (= A119), A141 (≠ G120), Y166 (= Y145), K170 (= K149), Y193 (= Y172), N195 (= N174), V196 (≠ I175)
- binding uridine-diphosphate-n-acetylgalactosamine: S103 (= S82), S142 (= S121), S143 (= S122), S144 (= S123), Y166 (= Y145), N195 (= N174), A209 (= A188), V210 (= V189), W214 (≠ F193), Y225 (≠ T204), I226 (= I205), N227 (≠ Y206), R234 (= R213), L271 (= L249), R299 (= R273), D302 (= D276), S306 (= S280)
Q7BJX9 UDP-N-acetylglucosamine 4-epimerase; UDP-GalNAc 4-epimerase; EC 5.1.3.7 from Plesiomonas shigelloides (Aeromonas shigelloides) (see 2 papers)
44% identity, 97% coverage: 5:310/314 of query aligns to 21:339/345 of Q7BJX9
- GVAGFI 26:31 (≠ GGAGFI 10:15) binding NAD(+)
- DNFSTG 50:55 (≠ DNLATG 34:39) binding NAD(+)
- DI 81:82 (≠ DV 57:58) binding NAD(+)
- QAA 101:103 (= QAA 77:79) binding NAD(+)
- T120 (≠ A96) binding NAD(+)
- SS 145:146 (= SS 121:122) binding substrate
- S147 (= S123) mutation to T: No effect on epimerase activity.
- Y169 (= Y145) binding NAD(+)
- K173 (= K149) binding NAD(+)
- YFN 196:198 (= YFN 172:174) binding substrate
- V199 (≠ I175) binding NAD(+)
- VIPK 213:216 (≠ VIPR 189:192) binding substrate
- YIN 228:230 (≠ TIY 204:206) binding substrate
- S236 (= S212) mutation to G: No effect on epimerase activity.
- R237 (= R213) binding substrate
- R271 (≠ Q246) mutation to G: No effect on epimerase activity.
- RSGD 302:305 (≠ RAGD 273:276) binding substrate
- R307 (= R278) mutation to A: No effect on epimerase activity.
- H308 (≠ E279) mutation to A: No effect on epimerase activity.
- S309 (= S280) mutation to Y: Abolishes epimerase activity.
3ruhA Alternative analogs as viable substrates of udp-hexose 4-epimerases
44% identity, 97% coverage: 5:310/314 of query aligns to 18:331/336 of 3ruhA
- active site: S142 (= S121), S143 (= S122), S144 (= S123), Y166 (= Y145), K170 (= K149), N204 (≠ Q183)
- binding nicotinamide-adenine-dinucleotide: G23 (= G10), G26 (= G13), F27 (= F14), I28 (= I15), D47 (= D34), N48 (= N35), S50 (≠ A37), T51 (= T38), G52 (= G39), D78 (= D57), I79 (≠ V58), Q98 (= Q77), A99 (= A78), A100 (= A79), T117 (≠ A96), A140 (= A119), A141 (≠ G120), S142 (= S121), Y166 (= Y145), K170 (= K149), Y193 (= Y172), V196 (≠ I175)
- binding [[(2R,3S,4R,5R)-5-[2,4-bis(oxidanylidene)pyrimidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl][(2R,3R,4R,5R,6R)-6-(hydroxymethyl)-4,5-bis(oxidanyl)-3-(2-oxidanylidenepropyl)oxan-2-yl] hydrogen phosphate: G102 (= G81), S103 (= S82), S142 (= S121), S143 (= S122), S144 (= S123), Y166 (= Y145), Y193 (= Y172), N195 (= N174), A209 (= A188), V210 (= V189), K213 (≠ R192), W214 (≠ F193), Y225 (≠ T204), I226 (= I205), N227 (≠ Y206), R234 (= R213), L271 (= L249), R294 (= R273), D297 (= D276), V298 (≠ P277), S301 (= S280)
3rufA Alternative analogs as viable substrates of udp-hexose 4-epimerases
44% identity, 97% coverage: 5:310/314 of query aligns to 18:331/336 of 3rufA
- active site: S142 (= S121), S143 (= S122), S144 (= S123), Y166 (= Y145), K170 (= K149), N204 (≠ Q183)
- binding nicotinamide-adenine-dinucleotide: G23 (= G10), G26 (= G13), F27 (= F14), I28 (= I15), D47 (= D34), N48 (= N35), S50 (≠ A37), T51 (= T38), G52 (= G39), D78 (= D57), I79 (≠ V58), Q98 (= Q77), A99 (= A78), A100 (= A79), T117 (≠ A96), A140 (= A119), Y166 (= Y145), K170 (= K149), Y193 (= Y172), V196 (≠ I175)
- binding uridine-5'-diphosphate: N195 (= N174), A209 (= A188), V210 (= V189), K213 (≠ R192), W214 (≠ F193), Y225 (≠ T204), I226 (= I205), N227 (≠ Y206), R234 (= R213), L271 (= L249), R294 (= R273), D297 (= D276)
3lu1A Crystal structure analysis of wbgu: a udp-galnac 4-epimerase (see paper)
44% identity, 97% coverage: 5:310/314 of query aligns to 18:331/336 of 3lu1A
- active site: S142 (= S121), S143 (= S122), S144 (= S123), Y166 (= Y145), K170 (= K149), N204 (≠ Q183)
- binding glycine: Q135 (≠ R114), K187 (≠ E166)
- binding nicotinamide-adenine-dinucleotide: G23 (= G10), G26 (= G13), F27 (= F14), I28 (= I15), D47 (= D34), N48 (= N35), S50 (≠ A37), T51 (= T38), G52 (= G39), D78 (= D57), I79 (≠ V58), Q98 (= Q77), A99 (= A78), A100 (= A79), A140 (= A119), A141 (≠ G120), S142 (= S121), Y166 (= Y145), K170 (= K149), Y193 (= Y172), N195 (= N174)
- binding uridine-diphosphate-n-acetylgalactosamine: S103 (= S82), S142 (= S121), S143 (= S122), S144 (= S123), Y166 (= Y145), N195 (= N174), V210 (= V189), W214 (≠ F193), Y225 (≠ T204), I226 (= I205), N227 (≠ Y206), R234 (= R213), L271 (= L249), R294 (= R273), D297 (= D276)
6dntA Udp-n-acetylglucosamine 4-epimerase from methanobrevibacter ruminantium m1 in complex with udp-n-acetylmuramic acid (see paper)
39% identity, 99% coverage: 1:310/314 of query aligns to 1:306/310 of 6dntA
- active site: S120 (= S121), S121 (= S122), A122 (≠ S123), Y144 (= Y145), K148 (= K149), A187 (= A188)
- binding (2R)-2-{[(2R,3R,4R,5S,6R)-3-(acetylamino)-2-{[(S)-{[(R)-{[(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methoxy}(hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]oxy}-5-hydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-4-yl]oxy}propanoic acid: A80 (≠ G81), S120 (= S121), S121 (= S122), Y144 (= Y145), F172 (= F173), N173 (= N174), A187 (= A188), V188 (= V189), K191 (≠ R192), V203 (≠ T204), I204 (= I205), Y205 (= Y206), Q210 (= Q211), R212 (= R213), I246 (≠ L249), R269 (= R273), D272 (= D276)
- binding nicotinamide-adenine-dinucleotide: G10 (= G10), G13 (= G13), F14 (= F14), I15 (= I15), D33 (= D34), N34 (= N35), L35 (= L36), S36 (≠ A37), S37 (≠ T38), G38 (= G39), D57 (= D57), L58 (≠ V58), L76 (≠ Q77), A77 (= A78), A78 (= A79), A80 (≠ G81), S118 (≠ A119), S119 (≠ G120), Y144 (= Y145), K148 (= K149), Y171 (= Y172), V174 (≠ I175)
- binding zinc ion: E209 (≠ L210), H275 (≠ E279)
4zrnA Crystal structure of udp-glucose 4-epimerase (tm0509) with udp-glucose from hyperthermophilic eubacterium thermotoga maritima (see paper)
38% identity, 98% coverage: 5:311/314 of query aligns to 2:305/309 of 4zrnA
- active site: T117 (≠ S121), G119 (vs. gap), A120 (≠ S123), Y143 (= Y145), K147 (= K149), Y181 (≠ Q183), G185 (≠ A188)
- binding nicotinamide-adenine-dinucleotide: G7 (= G10), G10 (= G13), F11 (= F14), I12 (= I15), D31 (= D34), N32 (= N35), S34 (≠ A37), S35 (≠ T38), G36 (= G39), S51 (≠ D57), I52 (≠ V58), L73 (≠ Q77), A74 (= A78), A75 (= A79), T92 (≠ A96), S115 (≠ A119), S116 (≠ G120), Y143 (= Y145), K147 (= K149), Y170 (= Y172), V173 (≠ I175)
- binding uridine-5'-diphosphate-glucose: T117 (≠ S121), G119 (vs. gap), A120 (≠ S123), Y143 (= Y145), N172 (= N174), G185 (≠ A188), V186 (= V189), H201 (≠ T204), F203 (≠ Y206), Y208 (≠ Q211), R210 (= R213), V244 (≠ L249), R267 (= R273), D270 (= D276)
6wjaA Udp-glcnac c4-epimerase mutant s121a/y146f from pseudomonas protegens in complex with udp-galnac (see paper)
38% identity, 96% coverage: 6:305/314 of query aligns to 3:302/307 of 6wjaA
- active site: A118 (≠ S121), A119 (≠ S122), A120 (≠ S123), F143 (≠ Y145), K147 (= K149)
- binding nicotinamide-adenine-dinucleotide: G7 (= G10), G10 (= G13), F11 (= F14), I12 (= I15), D31 (= D34), D32 (≠ N35), S34 (≠ A37), T35 (= T38), G36 (= G39), A55 (≠ V58), L74 (≠ Q77), A75 (= A78), A76 (= A79), S93 (≠ A96), F143 (≠ Y145), K147 (= K149), F170 (≠ Y172), F171 (= F173), I173 (= I175)
- binding uridine-diphosphate-n-acetylgalactosamine: V80 (= V83), A120 (≠ S123), N172 (= N174), G186 (≠ A188), V187 (= V189), F191 (= F193), T202 (= T204), F204 (≠ Y206), R211 (= R213), L247 (= L249), R270 (= R273), D273 (= D276)
6wj9B Udp-glcnac c4-epimerase mutant s121a/y146f from pseudomonas protegens in complex with udp-glcnac (see paper)
38% identity, 96% coverage: 6:305/314 of query aligns to 4:303/308 of 6wj9B
- active site: A119 (≠ S121), A120 (≠ S122), A121 (≠ S123), F144 (≠ Y145), K148 (= K149)
- binding nicotinamide-adenine-dinucleotide: G8 (= G10), G11 (= G13), F12 (= F14), I13 (= I15), D32 (= D34), D33 (≠ N35), S35 (≠ A37), T36 (= T38), G37 (= G39), D55 (= D57), A56 (≠ V58), L75 (≠ Q77), A76 (= A78), A77 (= A79), S94 (≠ A96), A117 (= A119), A119 (≠ S121), F144 (≠ Y145), K148 (= K149), F171 (≠ Y172), F172 (= F173), I174 (= I175)
- binding uridine-diphosphate-n-acetylglucosamine: V81 (= V83), N173 (= N174), G187 (≠ A188), V188 (= V189), F192 (= F193), T203 (= T204), L204 (≠ I205), F205 (≠ Y206), R212 (= R213), L248 (= L249), R271 (= R273), D274 (= D276)
6zldA Crystal structure of udp-glucuronic acid 4-epimerase from bacillus cereus in complex with udp-glucuronic acid and NAD (see paper)
36% identity, 97% coverage: 6:311/314 of query aligns to 3:311/314 of 6zldA
- active site: T126 (≠ S121), S127 (= S122), S128 (= S123), Y149 (= Y145), K153 (= K149)
- binding nicotinamide-adenine-dinucleotide: G7 (= G10), G10 (= G13), F11 (= F14), I12 (= I15), D32 (= D34), H33 (≠ N35), F34 (≠ L36), I35 (vs. gap), K43 (= K40), D62 (= D57), I63 (≠ V58), L81 (≠ Q77), A82 (= A78), A83 (= A79), I124 (≠ A119), T126 (≠ S121), K153 (= K149), Y176 (= Y172), T178 (≠ N174), R185 (≠ D181), M188 (≠ S184)
- binding uridine-5'-diphosphate-glucuronic acid: P85 (≠ G81), R88 (≠ P84), T126 (≠ S121), S127 (= S122), S128 (= S123), Y149 (= Y145), F177 (= F173), T178 (≠ N174), R185 (≠ D181), M188 (≠ S184), A189 (≠ E185), R192 (= R192), T204 (= T204), F206 (≠ Y206), Q211 (= Q211), R213 (= R213), I250 (≠ L249), E276 (≠ D276)
6zl6A Crystal structure of udp-glucuronic acid 4-epimerase from bacillus cereus in complex with udp and NAD (see paper)
36% identity, 97% coverage: 6:311/314 of query aligns to 3:311/314 of 6zl6A
- active site: T126 (≠ S121), S127 (= S122), S128 (= S123), Y149 (= Y145), K153 (= K149)
- binding nicotinamide-adenine-dinucleotide: G7 (= G10), G10 (= G13), F11 (= F14), I12 (= I15), D32 (= D34), H33 (≠ N35), F34 (≠ L36), I35 (vs. gap), K43 (= K40), D62 (= D57), I63 (≠ V58), L81 (≠ Q77), A82 (= A78), A83 (= A79), I124 (≠ A119), T126 (≠ S121), K153 (= K149), Y176 (= Y172), T178 (≠ N174), V179 (≠ I175), R185 (≠ D181), M188 (≠ S184)
- binding uridine-5'-diphosphate: T178 (≠ N174), A189 (≠ E185), R192 (= R192), T204 (= T204), F206 (≠ Y206), Q211 (= Q211), R213 (= R213), I250 (≠ L249), E276 (≠ D276)
6zllA Crystal structure of udp-glucuronic acid 4-epimerase from bacillus cereus in complex with udp-galacturonic acid and NAD (see paper)
36% identity, 97% coverage: 6:311/314 of query aligns to 3:311/321 of 6zllA
- active site: T126 (≠ S121), S127 (= S122), S128 (= S123), Y149 (= Y145), K153 (= K149)
- binding nicotinamide-adenine-dinucleotide: G7 (= G10), G10 (= G13), F11 (= F14), I12 (= I15), D32 (= D34), H33 (≠ N35), F34 (≠ L36), I35 (vs. gap), K43 (= K40), D62 (= D57), I63 (≠ V58), L81 (≠ Q77), A82 (= A78), A83 (= A79), I124 (≠ A119), T126 (≠ S121), Y149 (= Y145), K153 (= K149), Y176 (= Y172), V179 (≠ I175), R185 (≠ D181), M188 (≠ S184)
- binding (2S,3R,4S,5R,6R)-6-[[[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxy-3,4,5-trihydroxy-oxane-2-carboxylic acid: P85 (≠ G81), V87 (= V83), R88 (≠ P84), T126 (≠ S121), S127 (= S122), Y149 (= Y145), T178 (≠ N174), R185 (≠ D181), A189 (≠ E185), R192 (= R192), T204 (= T204), F206 (≠ Y206), Q211 (= Q211), R213 (= R213), I250 (≠ L249), E276 (≠ D276)
6zljA Crystal structure of udp-glucuronic acid 4-epimerase y149f mutant from bacillus cereus in complex with udp-4-deoxy-4-fluoro-glucuronic acid and NAD (see paper)
36% identity, 97% coverage: 6:311/314 of query aligns to 3:311/314 of 6zljA
- active site: T126 (≠ S121), S127 (= S122), S128 (= S123), F149 (≠ Y145), K153 (= K149)
- binding nicotinamide-adenine-dinucleotide: G7 (= G10), G10 (= G13), F11 (= F14), I12 (= I15), D32 (= D34), H33 (≠ N35), F34 (≠ L36), I35 (vs. gap), K43 (= K40), D62 (= D57), I63 (≠ V58), L81 (≠ Q77), A82 (= A78), A83 (= A79), I124 (≠ A119), T126 (≠ S121), K153 (= K149), Y176 (= Y172), T178 (≠ N174), V179 (≠ I175), R185 (≠ D181), M188 (≠ S184)
- binding (2~{R},3~{S},4~{R},5~{R},6~{R})-6-[[[(2~{R},3~{S},4~{R},5~{R})-5-[2,4-bis(oxidanylidene)pyrimidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-3-fluoranyl-4,5-bis(oxidanyl)oxane-2-carboxylic acid: P85 (≠ G81), R88 (≠ P84), T126 (≠ S121), S127 (= S122), S128 (= S123), F149 (≠ Y145), F177 (= F173), T178 (≠ N174), R185 (≠ D181), M188 (≠ S184), A189 (≠ E185), R192 (= R192), T204 (= T204), F206 (≠ Y206), Q211 (= Q211), R213 (= R213), I250 (≠ L249), E276 (≠ D276)
7ystA Crystal structure of udp-glucose 4-epimerase (rv3634c) in complex with both udp-glucose and udp-galactose in chain b from mycobacterium tuberculosis
39% identity, 98% coverage: 7:313/314 of query aligns to 4:311/312 of 7ystA
- binding nicotinamide-adenine-dinucleotide: G7 (= G10), G10 (= G13), F11 (= F14), I12 (= I15), D31 (= D34), N32 (= N35), T35 (= T38), G36 (= G39), D56 (= D57), I57 (≠ V58), L77 (≠ Q77), A78 (= A78), A79 (= A79), I81 (≠ G81), V96 (≠ A96), T119 (≠ A119), Y146 (= Y145), K150 (= K149), P173 (≠ Y172), A174 (≠ F173), N175 (= N174), V176 (≠ I175)
- binding uridine-5'-diphosphate-glucose: I81 (≠ G81), R84 (≠ P84), S121 (= S121), G123 (vs. gap), Y146 (= Y145), A174 (≠ F173), N175 (= N174), A187 (= A187), G188 (≠ A188), V189 (= V189), F193 (= F193), R204 (≠ T204), V205 (≠ I205), F206 (≠ Y206), R213 (= R213), D248 (≠ L249), R271 (= R273)
7ysmA Crystal structure of udp-glucose 4-epimerase (rv3634c) co-crystallized with udp-n-acetylglucosamine from mycobacterium tuberculosis
39% identity, 98% coverage: 7:313/314 of query aligns to 4:311/311 of 7ysmA
- binding nicotinamide-adenine-dinucleotide: G7 (= G10), G10 (= G13), F11 (= F14), I12 (= I15), D31 (= D34), N32 (= N35), T35 (= T38), G36 (= G39), D56 (= D57), I57 (≠ V58), L77 (≠ Q77), A78 (= A78), A79 (= A79), I81 (≠ G81), T119 (≠ A119), Y146 (= Y145), K150 (= K149), P173 (≠ Y172), N175 (= N174), V176 (≠ I175)
- binding uridine-diphosphate-n-acetylgalactosamine: I81 (≠ G81), R84 (≠ P84), S121 (= S121), G123 (vs. gap), S124 (= S123), Y146 (= Y145), A174 (≠ F173), N175 (= N174), G188 (≠ A188), V189 (= V189), F193 (= F193), R204 (≠ T204), V205 (≠ I205), F206 (≠ Y206), N211 (≠ Q211), R213 (= R213), D248 (≠ L249), R271 (= R273)
7ys9A Crystal structure of udp-glucose 4-epimerase (rv3634c) in complex with both udp-glucose and udp-galactose in chaina from mycobacterium tuberculosis
39% identity, 97% coverage: 7:311/314 of query aligns to 4:309/310 of 7ys9A
- binding galactose-uridine-5'-diphosphate: I81 (≠ G81), R84 (≠ P84), S121 (= S121), G123 (vs. gap), Y146 (= Y145), A174 (≠ F173), N175 (= N174), A187 (= A187), G188 (≠ A188), V189 (= V189), F193 (= F193), R204 (≠ T204), F206 (≠ Y206), N211 (≠ Q211), R213 (= R213), D248 (≠ L249), R271 (= R273)
- binding nicotinamide-adenine-dinucleotide: G7 (= G10), G10 (= G13), F11 (= F14), I12 (= I15), D31 (= D34), N32 (= N35), A34 (= A37), T35 (= T38), G36 (= G39), D56 (= D57), I57 (≠ V58), L77 (≠ Q77), A78 (= A78), A79 (= A79), I81 (≠ G81), T119 (≠ A119), Y146 (= Y145), K150 (= K149), P173 (≠ Y172), A174 (≠ F173), V176 (≠ I175)
- binding uridine-5'-diphosphate-glucose: I81 (≠ G81), R84 (≠ P84), S121 (= S121), G123 (vs. gap), Y146 (= Y145), A174 (≠ F173), N175 (= N174), A187 (= A187), G188 (≠ A188), V189 (= V189), F193 (= F193), R204 (≠ T204), F206 (≠ Y206), N211 (≠ Q211), R213 (= R213), D248 (≠ L249), R271 (= R273)
2p5uA Crystal structure of thermus thermophilus hb8 udp-glucose 4-epimerase complex with NAD
37% identity, 97% coverage: 6:311/314 of query aligns to 3:308/311 of 2p5uA
- active site: T117 (≠ S121), G119 (≠ S122), A120 (≠ S123), Y143 (= Y145), K147 (= K149), H181 (≠ Q183), G185 (≠ A188)
- binding nicotinamide-adenine-dinucleotide: G10 (= G13), F11 (= F14), I12 (= I15), D31 (= D34), N32 (= N35), L33 (= L36), A34 (= A37), T35 (= T38), G36 (= G39), D51 (= D57), L52 (≠ V58), Q73 (= Q77), A74 (= A78), A75 (= A79), A77 (≠ G81), S116 (≠ G120), Y143 (= Y145), K147 (= K149), V173 (≠ I175)
6pnlA Structure of epimerase mth375 from the thermophilic pseudomurein- containing methanogen methanothermobacter thermautotrophicus
33% identity, 98% coverage: 3:310/314 of query aligns to 15:323/336 of 6pnlA
- active site: S133 (= S121), C135 (≠ S123), G136 (vs. gap), Y159 (= Y145), K163 (= K149)
- binding nicotinamide-adenine-dinucleotide: G22 (= G10), G25 (= G13), C26 (≠ F14), D46 (= D34), N47 (= N35), L48 (= L36), S49 (≠ A37), S50 (≠ T38), S51 (≠ G39), D68 (= D57), I69 (≠ V58), L89 (≠ Q77), A91 (= A79), F93 (≠ G81), V108 (≠ A96), S131 (≠ A119), S133 (= S121), Y159 (= Y145), K163 (= K149), F186 (≠ Y172), N188 (= N174), V189 (≠ I175), R200 (≠ A187)
- binding uridine-5'-diphosphate: N188 (= N174), N201 (≠ A188), V202 (= V189), F206 (= F193), P217 (≠ T204), I218 (= I205), T219 (≠ Y206), R226 (= R213), V262 (≠ L249), R285 (= R273)
6pmhA Structure of epimerase mth375 from the thermophilic pseudomurein- containing methanogen methanothermobacter thermautotrophicus
33% identity, 98% coverage: 3:310/314 of query aligns to 9:317/330 of 6pmhA
- active site: S127 (= S121), C129 (≠ S123), G130 (vs. gap), Y153 (= Y145), K157 (= K149)
- binding adenosine monophosphate: G16 (= G10), G19 (= G13), D40 (= D34), N41 (= N35), S43 (≠ A37), S44 (≠ T38), S45 (≠ G39), D62 (= D57), I63 (≠ V58), A84 (= A78), F87 (≠ G81), R194 (≠ A187)
- binding uridine-5'-diphosphate: C129 (≠ S123), N182 (= N174), N195 (≠ A188), V196 (= V189), F200 (= F193), P211 (≠ T204), I212 (= I205), T213 (≠ Y206), R220 (= R213), V256 (≠ L249), R279 (= R273)
Query Sequence
>WP_014450383.1 NCBI__GCF_000284315.1:WP_014450383.1
MAGNTMLITGGAGFIGSNIARKLLAEGKTVAILDNLATGKRENIDDIKAHVRFIEGDVRD
RDLLKKILPDVEVIFHQAALGSVPRSIKDPFETQSANVDGTMAILWEAKHAGVRRVTIAG
SSSVYGDAPGMPRVETIVPSPLSPYALTKMSQEHLGAIFSKTYGLECVTLRYFNIFGPFQ
DPQSEYAAVIPRFITKIIKNEPITIYGDGLQSRDFTFIDNVVSANLLAARTKTGIGQAAN
IGCGAQFTLLDLVEELKKLLGKPNVAIDFQPPRAGDPRESRADIKKAEELLGYRPLVDFS
EGLKRTVEWFKART
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory