SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing WP_015334118.1 NCBI__GCF_000331105.1:WP_015334118.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

2pclA Crystal structure of abc transporter with complex (aq_297) from aquifex aeolicus vf5
49% identity, 98% coverage: 3:218/221 of query aligns to 3:217/223 of 2pclA

query
sites
2pclA

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binding magnesium ion: E165 (= E165), P166 (= P166), T167 (≠ S167), T196 (= T197)

P75957 Lipoprotein-releasing system ATP-binding protein LolD; EC 7.6.2.- from Escherichia coli (strain K12) (see paper)
48% identity, 98% coverage: 3:218/221 of query aligns to 5:224/233 of P75957

query
sites
P75957

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G42 (= G36) mutation to D: Loss of lipoprotein release when overexpressed.

7mdyC Lolcde nucleotide-bound
48% identity, 98% coverage: 3:218/221 of query aligns to 2:221/226 of 7mdyC

query
sites
7mdyC

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binding adp orthovanadate: Y12 (= Y13), G42 (= G39), S43 (≠ A40), G44 (= G41), K45 (= K42), S46 (= S43), T47 (= T44), Q91 (= Q88), H138 (= H135), E142 (≠ Q139), S144 (= S141), G145 (= G142), G146 (= G143), E168 (= E165), N172 (= N169), H201 (= H198)
binding magnesium ion: S46 (= S43), Q91 (= Q88)

7arlD Lolcde in complex with lipoprotein and adp (see paper)
48% identity, 98% coverage: 3:218/221 of query aligns to 2:221/222 of 7arlD

query
sites
7arlD

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binding adenosine-5'-diphosphate: G42 (= G39), G44 (= G41), K45 (= K42), S46 (= S43)

7v8iD Lolcd(e171q)e with bound amppnp in nanodiscs (see paper)
47% identity, 98% coverage: 3:218/221 of query aligns to 4:223/229 of 7v8iD

query
sites
7v8iD

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binding phosphoaminophosphonic acid-adenylate ester: V23 (= V18), S43 (= S38), G44 (= G39), G46 (= G41), K47 (= K42), S48 (= S43), T49 (= T44), Q93 (= Q88), R137 (= R132), H140 (= H135), E144 (≠ Q139), S146 (= S141), G148 (= G143), E149 (= E144), H203 (= H198)
binding magnesium ion: S48 (= S43), Q93 (= Q88)

P75831 Macrolide export ATP-binding/permease protein MacB; EC 7.6.2.- from Escherichia coli (strain K12) (see paper)
50% identity, 99% coverage: 2:219/221 of query aligns to 3:223/648 of P75831

query
sites
P75831

P

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N

N

V

V

A

E

I

V

P

P

G

A

F

V

I

Y

G

A

G

G

R

L

D

E

E

R

K

K

A

Q

V

R

R

L

Q

L

R

R

A

A

A

Q

E

E

L

L

L

L

S

Q

R

R

L

L

G

G

L

L

A

E

D

D

R

R

Q

T

Q

E

H

Y

F

Y

P

P

A

A

Q

Q

L

L

S

S

G

G

G

G

E

Q

Q

Q

Q

Q

R

R

V

V

A

S

V

I

A

A

R

R

A

A

L

L

I

M

N

N

Q

G

P

G

A

Q

V

V

V

I

F

L

A

A

D
|
D

E

E

P

P

S

T

G

G

N

A

L

L

D

D

S

S

R

H

N

S

A

G

E

E

E

E

L

V

H

M

Q

A

L

I

F

L

F

H

D

Q

L

L

R

R

D

D

T

R

F

-

G

G

Q

H

T

T

F

V

I

I

I

I

V

V

T

T

H

H

N

D

E

P

T

Q

L

V

A

A

M

A

L

Q

A

A

D

E

R

R

S

V

I

I

T

E

L

I

R

R

D

D

G

G

H

E

V

I

V

V

K

R

K47 (= K42) mutation to L: Lack of activity.
D169 (= D164) mutation to N: Lack of activity.

5lilA Structure of aggregatibacter actinomycetemcomitans macb bound to atpys (p21) (see paper)
43% identity, 99% coverage: 1:218/221 of query aligns to 1:221/615 of 5lilA

query
sites
5lilA

M

M

P

N

I

I

L

I

H

E

A

I

T

K

N

Q

L

L

R

N

R

R

A

Y

Y
x
F

G

G

P

E

-

G

-

E

-

N

-

R

L

V

P

H

V
|
V

L

L

N

K

D

D

V

I

S

S

L

L

S

S

I

I

D

E

A

R

G

G

E

D

V

F

V

V

S

A

I

I

V

M

G

G

A

Q

S
|
S

G
|
G

A

S

G
|
G

K
|
K

S
|
S

T
|
T

L

L

L

M

H

N

I

I

L

I

G

G

T

C

L

L

D

D

R

T

P

A

D

T

G

G

G

G

S

S

V

S

T

K

L

I

A

D

G

G

Q

K

D

E

V

T

F

I

S

E

L

L

T

T

D

N

K

D

Q

Q

L

L

A

S

R

D

F

L

R

R

N

S

E

Q

Q

K

I

F

G

G

F

F

V

I

F

F

Q
|
Q

F

R

H

Y

N

N

L

L

L

L

P

S

E

S

F

L

T

T

A

A

L

A

E

E

N

N

V

V

A

A

I

L

P

P

G

A

F

I

I

Y

G

A

G

G

R

M

D

P

E

Q

K

S

A

Q

V

R

R

L

Q

E

R

R

A

A

A

K

E

Q

L

L

L

L

S

E

R

K

L

L

G

G

L

L

A

G

D

D

R
x
K

Q

W

Q

Q

H

N

F

K

P

P

A

N

Q
|
Q

L

L

S
|
S

G

G

G
|
G

E
x
Q

Q

Q

Q

Q

R

R

V

V

A

S

V

I

A

A

R

R

A

A

L

L

I

M

N

N

Q

G

P

G

A

E

V

I

V

I

F

L

A

A

D

D

E

Q

P

P

S

T

G

G

N

A

L

L

D

D

S

S

R

H

N

S

A

G

E

E

E

N

L

V

H

M

Q

E

L

I

F

L

F

R

D

Q

L

L

R

H

D

E

T

E

F

-

G

G

Q

H

T

T

F

I

I

I

I

M

V

V

T

T

H

H

N

D

E

K

T

H

L

I

A

A

M

A

L

S

A

A

D

N

R

R

S

I

I

I

T

E

L

I

R

K

D

D

G

G

H

E

V

I

V

I

binding adenosine-5'-triphosphate: F13 (≠ Y13), V22 (= V18), S42 (= S38), G43 (= G39), G45 (= G41), K46 (= K42), S47 (= S43), T48 (= T44), Q92 (= Q88), K136 (≠ R132), Q143 (= Q139), S145 (= S141), G147 (= G143), Q148 (≠ E144)
binding magnesium ion: S47 (= S43), Q92 (= Q88)

5xu1B Structure of a non-canonical abc transporter from streptococcus pneumoniae r6 (see paper)
44% identity, 96% coverage: 3:215/221 of query aligns to 3:218/226 of 5xu1B

query
sites
5xu1B

I

L

L

I

H

S

A

L

T

K

N

N

L

I

R

F

R

R

A

S

Y

Y

-

R

-

N

-

G

-

D

G

Q

P

E

L

L

P

Q

V

V

L

L

N

K

D

N

V

I

S

N

L

L

S

E

I

V

D

N

A

E

G

G

E

E

V

F

V

V

S

A

I

I

V

M

G

G

A

P

S

S

G

G

A

S

G
|
G

K
|
K

S
|
S

T

T

L

L

L

M

H

N

I

T

L

I

G

G

T

M

L

L

D

D

R

T

P

P

D

T

G

S

G

G

S

E

V

Y

T

Y

L

L

A

E

G

G

Q

Q

D

E

V

V

F

A

S

G

L

L

T

G

D

E

K

K

Q

Q

L

L

A

A

R

K

F

V

R

R

N

N

E

Q

Q

Q

I

I

G

G

F

F

V

V

F

F

Q

Q

F

Q

H

F

N

F

L

L

L

L

P

S

E

K

F

L

T

N

A

A

L

L

E

Q

N

N

V

V

A

E

I

L

P

P

G

L

F

I

I

Y

G

A

G

G

R

V

D

S

E

S

K

S

A

K

V

R

R

R

Q

K

R

L

A

A

A

E

E

E

L

Y

L

L

S

D

R

K

L

V

G

E

L

L

A

T

D

E

R

R

Q

S

Q

H

H

H

F

L

P

P

A

S

Q

E

L

L

S

S

G

G

G

G

E

Q

Q

K

Q

Q

R

R

V

V

A

A

V

I

A

A

R

R

A

A

L

L

I

V

N

N

Q

N

P

P

A

S

V

I

V

I

F

L

A

A

D

D

E

E

P

P

S

T

G

G

N

A

L

L

D

D

S

T

R

K

N

T

A

G

E

N

E

Q

L

I

H

M

Q

Q

L

L

F

L

F

V

D

D

L

L

R

N

D

K

T

E

F

-

G

G

Q

K

T

T

F

I

I

I

I

M

V

V

T

T

H

H

N

E

E

P

T

E

L

I

A

A

M

A

L

Y

A

A

D

K

R

R

S

Q

I

I

T

V

L

I

R

R

D

D

G

G

binding magnesium ion: G45 (= G41), K46 (= K42), S47 (= S43)

5lj7A Structure of aggregatibacter actinomycetemcomitans macb bound to atp (p21) (see paper)
43% identity, 99% coverage: 1:218/221 of query aligns to 1:221/592 of 5lj7A

query
sites
5lj7A

M

M

P

N

I

I

L

I

H

E

A

I

T

K

N

Q

L

L

R

N

R

R

A

Y

Y

F

G

G

P

E

-

G

-

E

-

N

-

R

L

V

P

H

V
|
V

L

L

N

K

D

D

V

I

S

S

L

L

S

S

I

I

D

E

A

R

G

G

E

D

V

F

V

V

S

A

I

I

V

M

G

G

A

Q

S
|
S

G
|
G

A

S

G
|
G

K
|
K

S
|
S

T
|
T

L

L

L

M

H

N

I

I

L

I

G

G

T

C

L

L

D

D

R

T

P

A

D

T

G

G

G

G

S

S

V

S

T

K

L

I

A

D

G

G

Q

K

D

E

V

T

F

I

S

E

L

L

T

T

D

N

K

D

Q

Q

L

L

A

S

R

D

F

L

R

R

N

S

E

Q

Q

K

I

F

G

G

F

F

V

I

F

F

Q
|
Q

F

R

H

Y

N

N

L

L

L

L

P

S

E

S

F

L

T

T

A

A

L

A

E

E

N

N

V

V

A

A

I

L

P

P

G

A

F

I

I

Y

G

A

G

G

R

M

D

P

E

Q

K

S

A

Q

V

R

R

L

Q

E

R

R

A

A

A

K

E

Q

L

L

L

L

S

E

R

K

L

L

G

G

L

L

A

G

D

D

R
x
K

Q

W

Q

Q

H

N

F

K

P

P

A

N

Q
|
Q

L

L

S
|
S

G

G

G
|
G

E
x
Q

Q

Q

Q

Q

R

R

V

V

A

S

V

I

A

A

R

R

A

A

L

L

I

M

N

N

Q

G

P

G

A

E

V

I

V

I

F

L

A

A

D

D

E

Q

P

P

S

T

G

G

N

A

L

L

D

D

S

S

R

H

N

S

A

G

E

E

E

N

L

V

H

M

Q

E

L

I

F

L

F

R

D

Q

L

L

R

H

D

E

T

E

F

-

G

G

Q

H

T

T

F

I

I

I

I

M

V

V

T

T

H

H

N

D

E

K

T

H

L

I

A

A

M

A

L

S

A

A

D

N

R

R

S

I

I

I

T

E

L

I

R

K

D

D

G

G

H

E

V

I

V

I

binding adenosine-5'-triphosphate: V22 (= V18), S42 (= S38), G43 (= G39), G45 (= G41), K46 (= K42), S47 (= S43), T48 (= T44), Q92 (= Q88), K136 (≠ R132), Q143 (= Q139), S145 (= S141), G147 (= G143), Q148 (≠ E144)
binding magnesium ion: S47 (= S43), Q92 (= Q88)

1f3oA Crystal structure of mj0796 atp-binding cassette (see paper)
46% identity, 92% coverage: 19:221/221 of query aligns to 21:227/232 of 1f3oA

query
sites
1f3oA

L

L

N

K

D

N

V

V

S

N

L

L

S

N

I

I

D

K

A

E

G

G

E

E

V

F

V

V

S

S

I

I

V

M

G

G

A

P

S

S

G
|
G

A

S

G
|
G

K
|
K

S
|
S

T
|
T

L

M

L

L

H

N

I

I

L

I

G

G

T

C

L

L

D

D

R

K

P

P

D

T

G

E

G

G

S

E

V

V

T

Y

L

I

A

D

G

N

Q

I

D

K

V

T

F

N

S

D

L

L

T

D

D

D

K

D

Q

E

L

L

A

T

R

K

F

I

R

R

N

R

E

D

Q

K

I

I

G

G

F

F

V

V

F

F

Q

Q

F

Q

H

F

N

N

L

L

L

I

P

P

E

L

F

L

T

T

A

A

L

L

E

E

N

N

V

V

A

E

I

L

P

P

-

L

-

I

-

F

G

K

F

Y

I

R

G

G

G

A

R

M

D

S

E

G

K

E

A

E

V

R

R

R

Q

K

R

R

A

A

A

L

E

E

L

C

L

L

S

K

R

M

L

A

G

E

L

L

A

E

D

E

R

R

-

F

Q

A

Q

N

H

H

F

K

P

P

A

N

Q

Q

L

L

S

S

G

G

G

G

E

Q

Q

Q

Q

Q

R

R

V

V

A

A

V

I

A

A

R

R

A

A

L

L

I

A

N

N

Q

N

P

P

A

P

V

I

V

I

F

L

A

A

D

D

E

E

P

P

S

T

G

G

N

A

L

L

D

D

S

S

R

K

N

T

A

G

E

E

E

K

L

I

H

M

Q

Q

L

L

F

L

F

K

D

K

L

L

R

N

D

E

T

E

F

D

G

G

Q

K

T

T

F

V

I

V

I

V

V

V

T

T

H

H

N

D

E

I

T

N

L

V

A

A

M

R

L

F

A

G

D

E

R

R

S

I

I

I

T

Y

L

L

R

K

D

D

G

G

H

E

V

V

V

E

K

R

T

E

E

E

binding adenosine-5'-diphosphate: G41 (= G39), G43 (= G41), K44 (= K42), S45 (= S43), T46 (= T44)

Sites not aligning to the query:

binding adenosine-5'-diphosphate: 11

1l2tA Dimeric structure of mj0796, a bacterial abc transporter cassette (see paper)
45% identity, 92% coverage: 19:221/221 of query aligns to 21:227/230 of 1l2tA

query
sites
1l2tA

L

L

N

K

D

N

V

V

S

N

L

L

S

N

I

I

D

K

A

E

G

G

E

E

V

F

V

V

S

S

I

I

V

M

G

G

A

P

S
|
S

G
|
G

A
x
S

G
|
G

K
|
K

S
|
S

T
|
T

L

M

L

L

H

N

I

I

L

I

G

G

T

C

L

L

D

D

R

K

P

P

D

T

G

E

G

G

S

E

V

V

T

Y

L

I

A

D

G

N

Q

I

D

K

V

T

F

N

S

D

L

L

T

D

D

D

K

D

Q

E

L

L

A

T

R

K

F

I

R

R

N

R

E

D

Q

K

I

I

G

G

F

F

V

V

F

F

Q

Q

F

Q

H

F

N

N

L

L

L

I

P

P

E

L

F

L

T

T

A

A

L

L

E

E

N

N

V

V

A

E

I

L

P

P

-

L

-

I

-

F

G

K

F

Y

I

R

G

G

G

A

R

M

D

S

E

G

K

E

A

E

V

R

R

R

Q

K

R

R

A

A

A

L

E

E

L

C

L

L

S

K

R

M

L

A

G

E

L

L

A

E

D

E

R

R

-
x
F

Q

A

Q

N

H

H

F

K

P

P

A

N

Q
|
Q

L

L

S
|
S

G

G

G
|
G

E
x
Q

Q

Q

Q

Q

R

R

V

V

A

A

V

I

A

A

R

R

A

A

L

L

I

A

N

N

Q

N

P

P

A

P

V

I

V

I

F

L

A

A

D

D

E

Q

P

P

S

T

G

G

N

A

L

L

D

D

S

S

R

K

N

T

A

G

E

E

E

K

L

I

H

M

Q

Q

L

L

F

L

F

K

D

K

L

L

R

N

D

E

T

E

F

D

G

G

Q

K

T

T

F

V

I

V

I

V

V

V

T

T

H
|
H

N

D

E

I

T

N

L

V

A

A

M

R

L

F

A

G

D

E

R

R

S

I

I

I

T

Y

L

L

R

K

D

D

G

G

H

E

V

V

V

E

K

R

T

E

E

E

binding adenosine-5'-triphosphate: S40 (= S38), G41 (= G39), S42 (≠ A40), G43 (= G41), K44 (= K42), S45 (= S43), T46 (= T44), F138 (vs. gap), Q145 (= Q139), S147 (= S141), G149 (= G143), Q150 (≠ E144), H204 (= H198)

Sites not aligning to the query:

binding adenosine-5'-triphosphate: 11

5ws4A Crystal structure of tripartite-type abc transporter macb from acinetobacter baumannii (see paper)
43% identity, 98% coverage: 3:219/221 of query aligns to 4:223/650 of 5ws4A

query
sites
5ws4A

I

L

L

L

H

E

A

V

T

S

N

N

L

L

R

V

R

R

A

E

Y

F

-

P

-

A

-

G

-

E

G

S

P

T

L

I

P

Q

V

I

L

L

N

K

D

G

V

I

S

D

L

L

S

T

I

I

D

Y

A

E

G

G

E

E

V

L

V

V

S

A

I

I

V

V

G

G

A

Q

S
|
S

G
|
G

A

S

G

G

K

K

S
|
S

T

T

L

L

L

M

H

N

I

I

L

L

G

G

T

C

L

L

D

D

R

R

P

P

D

T

G

S

G

G

S

S

V

Y

T

K

L

V

A

N

G

G

Q

Q

D

E

V

T

F

G

S

K

L

L

T

E

D

P

K

D

Q

Q

L

L

A

A

R

Q

F

L

R

R

N

R

E

E

Q

Y

I

F

G

G

F

F

V

I

F

F

Q

Q

F

R

H

Y

N

H

L

L

L

L

P

G

E

D

F

L

T

S

A

A

L

E

E

G

N

N

V

V

A

E

I

V

P

P

G

A

F

V

I

Y

G

A

G

G

R

V

D

T

E

P

K

A

A

D

V

R

R

K

Q

Q

R

R

A

A

A

T

E

A

L

L

L

L

S

T

R

E

L

L

G

G

L

L

A

G

D

T

R

K

Q

T

Q

Q

H

N

F

R

P

P

A

S

Q

Q

L

L

S

S

G

G

G

G

E

Q

Q

Q

Q

Q

R

R

V

V

A

S

V

I

A

A

R

R

A

A

L

L

I

M

N

N

Q

G

P

G

A

D

V

V

V

I

F

L

A

A

D

D

E

E

P

P

S

T

G

G

N

A

L

L

D

D

S

S

R

H

N

S

A

G

E

V

E

E

L

V

H

M

Q

R

L

I

F

L

F

R

D

E

L

L

R

-

D

N

T

A

F

A

G

G

Q

H

T

T

F

I

I

I

I

L

V

V

T

T

H

H

N

D

E

M

T

Q

L

V

A

A

M

K

L

N

A

A

D

T

R

R

S

I

I

I

T

E

L

I

R

S

D

D

G

G

H

E

V

I

V

I

K

S

binding 5'-o-[(r)-hydroxy(thiophosphonooxy)phosphoryl]adenosine: S43 (= S38), G44 (= G39), S48 (= S43)

8g4cB Bceabs atpgs high res tm (see paper)
37% identity, 97% coverage: 3:217/221 of query aligns to 3:221/248 of 8g4cB

query
sites
8g4cB

I

I

L

L

H

E

A

A

T

N

N

K

L

I

R

R

R

K

A

S

Y
|
Y

G

G

-

N

-

K

-

L

-

N

P

K

L

Q

P

E

V

V

L

L

N

K

D

G

V

I

S

D

L

I

S

H

I

I

D

E

A

K

G

G

E

E

V

F

V

V

S

S

I

I

V

M

G

G

A

A

S
|
S

G

G

A
x
S

G

G

K

K

S
x
T

T

T

L

L

L

L

H

N

I

V

L

L

G

S

T

S

L

I

D

D

R

Q

P

V

D

S

G

H

G

G

S

T

V

I

T

H

L

I

A

N

G

G

Q

N

D

D

V

M

F

T

S

A

L

M

T

K

D

E

K

K

Q

Q

L

L

A

A

R

E

F

F

R

R

N

K

E

Q

Q

H

I

L

G

G

F

F

V

I

F

F

Q

Q

F

D

H

Y

N

N

L

L

L

L

P

D

E

T

F

L

T

T

A

V

L

K

E

E

N

N

V

I

A

L

I

L

P

P

G

L

F

S

I

I

G

T

G

K

R

L

D

S

E

K

K

K

A

E

V

A

R

N

Q

R

R

K

A

F

A

E

E

E

L

V

L

A

S

K

R

E

L

L

G

G

L

I

A

Y

D

E

R

L

Q

R

Q

D

H

K

F

Y

P

P

A

N

Q

E

L

I

S

S

G

G

G

G

E

Q

Q

K

Q

Q

R

R

V

T

A

S

V

A

A

G

R

R

A

A

L

F

I

I

N

H

Q

D

P

P

A

S

V

I

V

I

F

F

A

A

D
|
D

E

E

P

P

S

T

G

G

N

A

L

L

D

D

S

S

R

K

N

S

A

A

E

S

E

D

L

L

H

L

Q

N

L

K

F

L

F

S

D

Q

L

L

R

N

D

Q

T

K

F

R

G

N

Q

A

T

T

F

I

I

I

I

M

V

V

T

T

H

H

N

D

E

P

T

V

L

A

A

A

M

S

L

Y

A

C

D

G

R

R

S

V

I

I

T

F

L

I

R

K

D

D

G

G

H

Q

V

M

binding phosphothiophosphoric acid-adenylate ester: Y13 (= Y13), S42 (= S38), S44 (≠ A40), T47 (≠ S43), D168 (= D164)

7tchB Bceab e169q variant atp-bound conformation (see paper)
37% identity, 97% coverage: 3:217/221 of query aligns to 2:220/245 of 7tchB

query
sites
7tchB

I

I

L

L

H

E

A

A

T

N

N

K

L

I

R

R

R

K

A

S

Y
|
Y

G

G

-

N

-

K

-

L

-

N

P

K

L
x
Q

P

E

V
|
V

L

L

N

K

D

G

V

I

S

D

L

I

S

H

I

I

D

E

A

K

G

G

E

E

V

F

V

V

S

S

I

I

V

M

G

G

A

A

S
|
S

G
|
G

A
x
S

G

G

K
|
K

S
x
T

T

T

L

L

L

L

H

N

I

V

L

L

G

S

T

S

L

I

D

D

R

Q

P

V

D

S

G

H

G

G

S

T

V

I

T

H

L

I

A

N

G

G

Q

N

D

D

V

M

F

T

S

A

L

M

T

K

D

E

K

K

Q

Q

L

L

A

A

R

E

F

F

R

R

N

K

E

Q

Q

H

I

L

G

G

F

F

V

I

F

F

Q

Q

F

D

H

Y

N

N

L

L

L

L

P

D

E

T

F

L

T

T

A

V

L

K

E

E

N

N

V

I

A

L

I

L

P

P

G

L

F

S

I

I

G

T

G

K

R

L

D

S

E

K

K

K

A

E

V

A

R

N

Q

R

R

K

A

F

A

E

E

E

L

V

L

A

S

K

R

E

L

L

G

G

L

I

A

Y

D

E

R

L

Q

R

Q

D

H

K

F

Y

P

P

A

N

Q
x
E

L

I

S

S

G
|
G

G
|
G

E

Q

Q

K

Q

Q

R

R

V

T

A

S

V

A

A

G

R

R

A

A

L

F

I

I

N

H

Q

D

P

P

A

S

V

I

V

I

F

F

A

A

D

D

E

Q

P

P

S

T

G

G

N

A

L

L

D

D

S

S

R

K

N

S

A

A

E

S

E

D

L

L

H

L

Q

N

L

K

F

L

F

S

D

Q

L

L

R

N

D

Q

T

K

F

R

G

N

Q

A

T

T

F

I

I

I

I

M

V

V

T

T

H

H

N

D

E

P

T

V

L

A

A

A

M

S

L

Y

A

C

D

G

R

R

S

V

I

I

T

F

L

I

R

K

D

D

G

G

H

Q

V

M

binding adenosine-5'-triphosphate: Y12 (= Y13), Q19 (≠ L16), V21 (= V18), S41 (= S38), G42 (= G39), S43 (≠ A40), K45 (= K42), T46 (≠ S43), E142 (≠ Q139), G145 (= G142), G146 (= G143)

8w6iD Cryo-em structure of escherichia coli str k12 ftsex complex with atp- gamma-s in peptidisc
41% identity, 95% coverage: 8:217/221 of query aligns to 6:215/219 of 8w6iD

query
sites
8w6iD

N

H

L

V

R

S

R

K

A

A

Y
|
Y

-

L

G

G

P

G

L

R

P

Q

V

A

L

L

N

Q

D

G

V

V

S

T

L

F

S

H

I

M

D

Q

A

P

G

G

E

E

V

M

V

A

S

F

I

L

V

T

G

G

A

H

S
|
S

G
|
G

A
|
A

G
|
G

K
|
K

S
|
S

T
|
T

L

L

L

L

H

K

I

L

L

I

G

C

T

G

L

I

D

E

R

R

P

P

D

S

G

A

G

G

S

K

V

I

T

W

L

F

A

S

G

G

Q

H

D

D

V

I

F

T

S

R

L

L

T

K

D

N

K

R

Q

E

L

V

A

P

R

-

F

F

R

L

N

R

E

R

Q

Q

I

I

G

G

F

M

V

I

F

F

Q
|
Q

F

D

H

H

N

H

L

L

L

L

P

M

E

D

F

R

T

T

A

V

L

Y

E

D

N

N

V

V

A

A

I

I

P

P

G

L

F

I

I

I

G

A

G

G

R

A

D

S

E

G

K

D

A

D

V

I

R

R

Q

R

R

R

A

V

A

S

E

A

L

A

L

L

S

D

R

K

L

V

G

G

L

L

A

L

D

D

R
x
K

Q

A

Q

K

H

N

F

F

P

P

A

I

Q
|
Q

L

L

S
|
S

G
|
G

G
|
G

E
|
E

Q

Q

Q

Q

R

R

V

V

A

G

V

I

A

A

R

R

A

A

L

V

I

V

N

N

Q

K

P

P

A

A

V

V

V

L

F

L

A

A

D

D

E

E

P

P

S

T

G

G

N

N

L

L

D

D

S

D

R

A

N

L

A

S

E

E

E

G

L

I

H

L

Q

R

L

L

F

F

F

E

D

E

L

F

R

-

D

N

T

R

F

V

G

G

Q

V

T

T

F

V

I

L

I

M

V

A

T

T

H
|
H

N

D

E

I

T

N

L

L

-

I

A

S

M

R

L

R

A

S

D

Y

R

R

S

M

I

L

T

T

L

L

R

S

D

D

G

G

H

H

V

L

binding phosphothiophosphoric acid-adenylate ester: Y11 (= Y13), S37 (= S38), G38 (= G39), A39 (= A40), G40 (= G41), K41 (= K42), S42 (= S43), T43 (= T44), Q86 (= Q88), K130 (≠ R132), Q137 (= Q139), S139 (= S141), G140 (= G142), G141 (= G143), E142 (= E144), H195 (= H198)

P0A9R7 Cell division ATP-binding protein FtsE from Escherichia coli (strain K12) (see paper)
41% identity, 95% coverage: 8:217/221 of query aligns to 6:215/222 of P0A9R7

query
sites
P0A9R7

N

H

L

V

R

S

R

K

A

A

Y

Y

-

L

G

G

P

G

L

R

P

Q

V

A

L

L

N

Q

D

G

V

V

S

T

L

F

S

H

I

M

D

Q

A

P

G

G

E

E

V

M

V

A

S

F

I

L

V

T

G

G

A

H

S

S

G

G

A

A

G

G

K
|
K

S

S

T

T

L

L

L

L

H

K

I

L

L

I

G
x
C

T

G

L

I

D

E

R

R

P

P

D

S

G

A

G

G

S

K

V

I

T

W

L

F

A

S

G

G

Q

H

D

D

V

I

F

T

S

R

L

L

T

K

D

N

K

R

Q

E

L

V

A

P

R

-

F

F

R

L

N

R

E

R

Q

Q

I

I

G

G

F

M

V

I

F

F

Q

Q

F

D

H

H

N

H

L

L

L

L

P

M

E

D

F

R

T

T

A

V

L

Y

E

D

N

N

V

V

A

A

I

I

P

P

G

L

F

I

I

I

G

A

G

G

R

A

D

S

E

G

K

D

A

D

V

I

R

R

Q

R

R

R

A

V

A

S

E

A

L

A

L

L

S

D

R

K

L

V

G

G

L

L

A

L

D

D

R

K

Q

A

Q

K

H

N

F

F

P

P

A

I

Q

Q

L

L

S

S

G

G

G

G

E

E

Q

Q

Q

Q

R

R

V

V

A

G

V

I

A

A

R

R

A

A

L

V

I

V

N

N

Q

K

P

P

A

A

V

V

V

L

F

L

A

A

D

D

E

E

P

P

S

T

G

G

N

N

L

L

D

D

S

D

R

A

N

L

A

S

E

E

E

G

L

I

H

L

Q

R

L

L

F

F

F

E

D

E

L

F

R

-

D

N

T

R

F

V

G

G

Q

V

T

T

F

V

I

L

I

M

V

A

T

T

H

H

N

D

E

I

T

N

L

L

-

I

A

S

M

R

L

R

A

S

D

Y

R

R

S

M

I

L

T

T

L

L

R

S

D

D

G

G

H

H

V

L

K41 (= K42) mutation to R: Does not bind ATP.
C49 (≠ G50) mutation to A: Prevents dimer formation. Does not alter ATP-binding.

8hd0A Cell divisome spg hydrolysis machinery ftsex-envc
41% identity, 95% coverage: 8:217/221 of query aligns to 6:215/218 of 8hd0A

query
sites
8hd0A

N

H

L

V

R

S

R

K

A

A

Y
|
Y

-

L

G

G

P

G

L
x
R

P

Q

V
x
A

L

L

N

Q

D

G

V

V

S

T

L

F

S

H

I

M

D

Q

A

P

G

G

E

E

V

M

V

A

S

F

I

L

V

T

G

G

A

H

S

S

G

G

A

A

G
|
G

K
|
K

S
|
S

T
|
T

L

L

L

L

H

K

I

L

L

I

G

C

T

G

L

I

D

E

R

R

P

P

D

S

G

A

G

G

S

K

V

I

T

W

L

F

A

S

G

G

Q

H

D

D

V

I

F

T

S

R

L

L

T

K

D

N

K

R

Q

E

L

V

A

P

R

-

F

F

R

L

N

R

E

R

Q

Q

I

I

G

G

F

M

V

I

F

F

Q

Q

F

D

H

H

N

H

L

L

L

L

P

M

E

D

F

R

T

T

A

V

L

Y

E

D

N

N

V

V

A

A

I

I

P

P

G

L

F

I

I

I

G

A

G

G

R

A

D

S

E

G

K

D

A

D

V

I

R

R

Q

R

R

R

A

V

A

S

E

A

L

A

L

L

S

D

R

K

L

V

G

G

L

L

A

L

D

D

R

K

Q

A

Q

K

H

N

F

F

P

P

A

I

Q

Q

L

L

S
|
S

G

G

G
|
G

E

E

Q

Q

Q

Q

R

R

V

V

A

G

V

I

A

A

R

R

A

A

L

V

I

V

N

N

Q

K

P

P

A

A

V

V

V

L

F

L

A

A

D

D

E

Q

P

P

S

T

G

G

N

N

L

L

D

D

S

D

R

A

N

L

A

S

E

E

E

G

L

I

H

L

Q

R

L

L

F

F

F

E

D

E

L

F

R

-

D

N

T

R

F

V

G

G

Q

V

T

T

F

V

I

L

I

M

V

A

T

T

H

H

N

D

E

I

T

N

L

L

-

I

A

S

M

R

L

R

A

S

D

Y

R

R

S

M

I

L

T

T

L

L

R

S

D

D

G

G

H

H

V

L

binding adenosine-5'-triphosphate: Y11 (= Y13), R15 (≠ L16), A17 (≠ V18), G40 (= G41), K41 (= K42), S42 (= S43), T43 (= T44), S139 (= S141), G141 (= G143)

P30750 Methionine import ATP-binding protein MetN; EC 7.4.2.11 from Escherichia coli (strain K12) (see 3 papers)
38% identity, 91% coverage: 19:219/221 of query aligns to 21:221/343 of P30750

query
sites
P30750

L

L

N

N

D

N

V

V

S

S

L

L

S

H

I

V

D

P

A

A

G

G

E

Q

V

I

V

Y

S

G

I

V

V

I

G

G

A

A

S
|
S

G
|
G

A
|
A

G
|
G

K
|
K

S
|
S

T
|
T

L

L

L

I

H

R

I

C

L

V

G

N

T

L

L

L

D

E

R

R

P

P

D

T

G

E

G

G

S

S

V

V

T

L

L

V

A

D

G

G

Q

Q

D

E

V

L

F

T

S

T

L

L

T

S

D

E

K

S

Q

E

L

L

A

T

R

K

F

A

R

R

N

-

E

R

Q

Q

I

I

G

G

F

M

V

I

F

F

Q

Q

F

H

H

F

N

N

L

L

L

L

P

S

E

S

F

R

T

T

A

V

L

F

E

G

N

N

V

V

A

A

I

L

P

P

G

L

F

E

I

L

G

D

G

N

R

T

D

P

E

K

K

D

A

E

V

V

R

K

Q

R

R

R

A

V

A

T

E

E

L

L

L

L

S

S

R

L

L

V

G

G

L

L

A

G

D

D

R

K

Q

H

Q

D

H

S

F

Y

P

P

A

S

Q

N

L

L

S

S

G

G

G

G

E

Q

Q

K

Q

Q

R

R

V

V

A

A

V

I

A

A

R

R

A

A

L

L

I

A

N

S

Q

N

P

P

A

K

V

V

V

L

F

L

A

C

D

D

E
|
E

P

A

S

T

G

S

N

A

L

L

D

D

S

P

R

A

N

T

A

T

E

R

E

S

L

I

H

L

Q

E

L

L

F

L

F

K

D

D

L

I

R

N

D

R

T

R

F

L

G

G

Q

L

T

T

F

I

I

L

I

L

V

I

T

T

H

H

N

E

-

M

E

D

T

V

L

V

A

K

M

R

L

I

A

C

D

D

R

C

S

V

I

A

T

V

L

I

R

S

D

N

G

G

H

E

V

L

V

I

K

E

40:46 (vs. 38:44, 100% identical) binding ATP
E166 (= E165) mutation to Q: Exhibits little ATPase activity.

Sites not aligning to the query:

278:283 binding L-methionine
295 N→A: Reduces the binding of L-methionine to undetectable levels.
295:296 binding L-methionine

8i6rB Cryo-em structure of pseudomonas aeruginosa ftse(e163q)x/envc complex with atp in peptidisc (see paper)
40% identity, 90% coverage: 19:218/221 of query aligns to 18:216/222 of 8i6rB

query
sites
8i6rB

L

L

N

H

D

E

V

V

S

S

L

F

S

R

I

V

D

H

A

R

G

G

E

E

V

I

V

L

S

F

I

V

V

T

G

G

A

H

S
|
S

G

G

A
|
A

G
|
G

K
|
K

S
|
S

T
|
T

L

L

L

L

H

R

I

L

L

I

G

L

T

A

L

M

D

E

R

R

P

P

D

T

G

S

G

G

S

K

V

L

T

L

L

L

A

G

G

G

Q

Q

D

D

V

L

F

G

S

R

L

I

T

T

D

T

K

A

Q

Q

L

I

A

P

R

-

F

F

R

L

N

R

E

R

Q

Q

I

I

G

G

F

V

V

V

F

F

Q

Q

F

N

H

H

N

Q

L

L

L

L

P

T

E

D

F

R

T

T

A

V

L

A

E

D

N

N

V

I

A

A

I

L

P

P

G

L

F

Q

I

I

G

L

G

G

R

M

D

P

E

K

K

P

A

E

V

I

R

A

Q

K

R

R

A

V

A

A

E

S

L

A

L

L

S

E

R

R

L

V

G

N

L

L

A

K

D

E

R

K

Q

G

Q

E

H

A

F

L

P

P

A

S

Q
x
D

L

L

S
|
S

G
x
T

G
|
G

E
x
Q

Q

Q

Q

Q

R

R

V

V

A

G

V

I

A

A

R

R

A

A

L

I

I

V

N

H

Q

Q

P

P

A

A

V

L

V

L

F

L

A

A

D

D

E

Q

P

P

S

T

G

G

N

N

L

L

D

D

S

P

R

R

N

L

A

A

E

S

E

E

L

I

H

M

Q

G

L

V

F

F

F

E

D

D

L

I

R

-

D

N

T

R

F

L

G

G

Q

T

T

T

F

V

I

L

I

I

V

A

T

S

H

H

N

D

E

L

T

A

L

L

-

I

A

A

M

R

L

M

A

R

D

H

R

R

S

M

I

L

T

T

L

L

R

Q

D

R

G

G

H

R

V

I

V

I

binding adenosine-5'-triphosphate: S37 (= S38), A39 (= A40), G40 (= G41), K41 (= K42), S42 (= S43), T43 (= T44), D137 (≠ Q139), S139 (= S141), T140 (≠ G142), G141 (= G143), Q142 (≠ E144)
binding magnesium ion: K41 (= K42), S42 (= S43)

Sites not aligning to the query:

binding adenosine-5'-triphosphate: 11, 15

6cvlD Crystal structure of the escherichia coli atpgs-bound metni methionine abc transporter in complex with its metq binding protein (see paper)
38% identity, 91% coverage: 19:219/221 of query aligns to 22:222/344 of 6cvlD

query
sites
6cvlD

L

L

N

N

D

N

V

V

S

S

L

L

S

H

I

V

D

P

A

A

G

G

E

Q

V

I

V

Y

S

G

I

V

V

I

G

G

A

A

S
|
S

G
|
G

A
|
A

G
|
G

K
|
K

S
|
S

T
|
T

L

L

L

I

H

R

I

C

L

V

G

N

T

L

L

L

D

E

R

R

P

P

D

T

G

E

G

G

S

S

V

V

T

L

L

V

A

D

G

G

Q

Q

D

E

V

L

F

T

S

T

L

L

T

S

D

E

K

S

Q

E

L

L

A

T

R

K

F

A

R

R

N

-

E

R

Q

Q

I

I

G

G

F

M

V

I

F

F

Q

Q

F

H

H

F

N

N

L

L

L

L

P

S

E

S

F

R

T

T

A

V

L

F

E

G

N

N

V

V

A

A

I

L

P

P

G

L

F

E

I

L

G

D

G

N

R

T

D

P

E

K

K

D

A

E

V

V

R

K

Q

R

R

R

A

V

A

T

E

E

L

L

L

L

S

S

R

L

L

V

G

G

L

L

A

G

D

D

R

K

Q

H

Q

D

H

S

F

Y

P

P

A

S

Q
x
N

L

L

S
|
S

G

G

G

G

E
x
Q

Q

K

Q

Q

R

R

V

V

A

A

V

I

A

A

R

R

A

A

L

L

I

A

N

S

Q

N

P

P

A

K

V

V

V

L

F

L

A

C

D

D

E

Q

P

A

S

T

G

S

N

A

L

L

D

D

S

P

R

A

N

T

A

T

E

R

E

S

L

I

H

L

Q

E

L

L

F

L

F

K

D

D

L

I

R

N

D

R

T

R

F

L

G

G

Q

L

T

T

F

I

I

L

I

L

V

I

T

T

H
|
H

N

E

-

M

E

D

T

V

L

V

A

K

M

R

L

I

A

C

D

D

R

C

S

V

I

A

T

V

L

I

R

S

D

N

G

G

H

E

V

L

V

I

K

E

binding phosphothiophosphoric acid-adenylate ester: S41 (= S38), G42 (= G39), A43 (= A40), G44 (= G41), K45 (= K42), S46 (= S43), T47 (= T44), N141 (≠ Q139), S143 (= S141), Q146 (≠ E144), H200 (= H198)

Sites not aligning to the query:

binding phosphothiophosphoric acid-adenylate ester: 12, 14, 19

Query Sequence

>WP_015334118.1 NCBI__GCF_000331105.1:WP_015334118.1
MPILHATNLRRAYGPLPVLNDVSLSIDAGEVVSIVGASGAGKSTLLHILGTLDRPDGGSV
TLAGQDVFSLTDKQLARFRNEQIGFVFQFHNLLPEFTALENVAIPGFIGGRDEKAVRQRA
AELLSRLGLADRQQHFPAQLSGGEQQRVAVARALINQPAVVFADEPSGNLDSRNAEELHQ
LFFDLRDTFGQTFIIVTHNETLAMLADRSITLRDGHVVKTE

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory