Comparing WP_015412066.1 NCBI__GCF_000007065.1:WP_015412066.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
3dc2A Crystal structure of serine bound d-3-phosphoglycerate dehydrogenase from mycobacterium tuberculosis (see paper)
38% identity, 96% coverage: 3:503/523 of query aligns to 4:505/526 of 3dc2A
O43175 D-3-phosphoglycerate dehydrogenase; 3-PGDH; 2-oxoglutarate reductase; Malate dehydrogenase; EC 1.1.1.95; EC 1.1.1.399; EC 1.1.1.37 from Homo sapiens (Human) (see 3 papers)
44% identity, 77% coverage: 2:404/523 of query aligns to 8:412/533 of O43175
Sites not aligning to the query:
3ddnB Crystal structure of hydroxypyruvic acid phosphate bound d-3- phosphoglycerate dehydrogenase in mycobacterium tuberculosis (see paper)
38% identity, 96% coverage: 3:503/523 of query aligns to 5:504/525 of 3ddnB
6plfA Crystal structure of human phgdh complexed with compound 1 (see paper)
51% identity, 58% coverage: 2:302/523 of query aligns to 4:305/305 of 6plfA
6rj5A Crystal structure of phgdh in complex with compound 39 (see paper)
51% identity, 57% coverage: 2:299/523 of query aligns to 3:301/301 of 6rj5A
7ewhA Crystal structure of human phgdh in complex with homoharringtonine (see paper)
51% identity, 57% coverage: 2:300/523 of query aligns to 3:302/302 of 7ewhA
6rihA Crystal structure of phgdh in complex with compound 9 (see paper)
51% identity, 57% coverage: 2:300/523 of query aligns to 3:302/302 of 6rihA
6plgA Crystal structure of human phgdh complexed with compound 15 (see paper)
51% identity, 57% coverage: 2:300/523 of query aligns to 3:302/303 of 6plgA
6cwaA Crystal structure phgdh in complex with nadh and 3-phosphoglycerate at 1.77 a resolution (see paper)
51% identity, 57% coverage: 2:297/523 of query aligns to 2:298/299 of 6cwaA
7dkmA Phgdh covalently linked to oridonin (see paper)
51% identity, 57% coverage: 2:300/523 of query aligns to 4:303/306 of 7dkmA
6rj3A Crystal structure of phgdh in complex with compound 15 (see paper)
52% identity, 56% coverage: 2:293/523 of query aligns to 2:294/297 of 6rj3A
6rj2A Crystal structure of phgdh in complex with compound 40 (see paper)
51% identity, 57% coverage: 3:300/523 of query aligns to 1:299/299 of 6rj2A
6plfB Crystal structure of human phgdh complexed with compound 1 (see paper)
48% identity, 57% coverage: 2:299/523 of query aligns to 2:292/292 of 6plfB
1wwkA Crystal structure of phosphoglycerate dehydrogenase from pyrococcus horikoshii ot3
43% identity, 58% coverage: 1:302/523 of query aligns to 1:304/304 of 1wwkA
7cvpA The crystal structure of human phgdh from biortus.
53% identity, 42% coverage: 77:297/523 of query aligns to 33:253/254 of 7cvpA
5ofwA Crystal structure of human 3-phosphoglycerate dehydrogenase in complex with 3-chloro-4-fluorobenzamide (see paper)
56% identity, 37% coverage: 94:285/523 of query aligns to 2:193/195 of 5ofwA
5ofvA Crystal structure of human 3-phosphoglycerate dehydrogenase in complex with 5-fluoro-2-methylbenzoic acid (see paper)
56% identity, 37% coverage: 94:285/523 of query aligns to 2:193/195 of 5ofvA
5ofmA Crystal structure of human 3-phosphoglycerate dehydrogenase in complex with 5-amino-1-methyl-1h-indole
56% identity, 37% coverage: 94:285/523 of query aligns to 2:193/195 of 5ofmA
5nzqA Crystal structure of human 3-phosphoglycerate dehydrogenase in complex with 3-(1,3-oxazol-5-yl)aniline. (see paper)
56% identity, 37% coverage: 94:285/523 of query aligns to 2:193/195 of 5nzqA
5nzpA Crystal structure of human 3-phosphoglycerate dehydrogenase in complex with 3-hydroxybenzisoxazole (see paper)
56% identity, 37% coverage: 94:285/523 of query aligns to 2:193/195 of 5nzpA
>WP_015412066.1 NCBI__GCF_000007065.1:WP_015412066.1
MKVLVSDSLSNEGLEILKEHFDIDVCTGLCEDELVEKIKGYDALVIRSGTQVTQRIIEAA
DNLKIIGRAGVGVDNVDVDAATKKGIIVANAPEGNMISAAEHTIAMMMSMSRNIPQANAS
LKAREWKRNKFMGVEVKGKTLGVIGLGRIGSEVAKRAAGLEMNLMGYDPFISEKRAMELG
VKLATVNEIAKEADYITVHTPLIKETRNILDDEQFALMKKGVRVLNCARGGIINEEALAR
ALESGKVGGAAIDVFVEEPPFSSPLLNFDNVIVTPHLGASTQEAQVNVAIDIAKEVVSVL
TGGSAKNAINIPSVKPEAMAVLAPYIRLSELMGKIAGQLVDSNYEKVEIAYNGEISGKDT
RPLTVSALKGLLEMAVGSGVNYVNAPILAKSRKIAVVESKSESAEEYSSTVSIRLSSGES
TKMVAGTVVGDEPKIVSIDDDKVDIFPAGRMIFAKHINKPNVIGPCCMVLGKNNINISGM
QVGRSEVGGVTMMVLNVDTDVSDAILDEVRQVPGILNAKLVTL
Or try a new SitesBLAST search
SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory