SitesBLAST
Comparing WP_015739079.1 NCBI__GCF_000024605.1:WP_015739079.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
6w45A Crystal structure of hao1 in complex with biaryl acid inhibitor - compound 3 (see paper)
36% identity, 86% coverage: 48:337/339 of query aligns to 38:323/325 of 6w45A
- active site: Y130 (≠ P146), D158 (= D176), H222 (= H236)
- binding flavin mononucleotide: A77 (= A86), T78 (≠ P87), A79 (≠ I88), S106 (≠ A115), Q128 (≠ G144), T156 (≠ D174), K198 (= K212), H222 (= H236), G223 (= G237), R225 (= R239), D253 (= D267), G254 (= G268), R257 (= R271), G276 (= G290), R277 (= R291)
- binding 2-chloranyl-4-[2-[[(6-chloranyl-1~{H}-indol-2-yl)carbonyl-methyl-amino]methyl]-5-fluoranyl-phenyl]benzoic acid: A79 (≠ I88), M80 (≠ T89), M83 (≠ T92), W108 (≠ M129), Y130 (≠ P146), L162 (= L180), L167 (= L185), V171 (vs. gap), H222 (= H236)
Sites not aligning to the query:
6a4gA Mandelate oxidase mutant-y128f with the monooxide fmn adduct (see paper)
38% identity, 88% coverage: 30:328/339 of query aligns to 7:303/314 of 6a4gA
- active site: F121 (≠ I148), D149 (= D174), H211 (= H236)
- binding 1-deoxy-1-[(4aS)-4a-hydroxy-7,8-dimethyl-2,4-dioxo-3,4,4a,5-tetrahydrobenzo[g]pteridin-10(2H)-yl]-5-O-phosphono-D-ribitol: L18 (vs. gap), P70 (= P87), V71 (≠ I88), F121 (≠ I148), T147 (≠ G172), K187 (= K212), H211 (= H236), R214 (= R239), D242 (= D267), G243 (= G268), G244 (= G269), R246 (= R271), R266 (= R291)
7m2oA Crystal structure of human glycolate oxidase with inhibitor compound 15
35% identity, 86% coverage: 48:337/339 of query aligns to 41:333/335 of 7m2oA
- binding flavin mononucleotide: A80 (= A86), T81 (≠ P87), A82 (≠ I88), S109 (≠ A115), Q131 (≠ G144), Y133 (≠ P146), T159 (≠ D174), K208 (= K212), H232 (= H236), G233 (= G237), R235 (= R239), D263 (= D267), G264 (= G268), R267 (= R271), G286 (= G290), R287 (= R291)
- binding 5-[(5'-{1-(4-carboxy-1,3-thiazol-2-yl)-5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-1H-pyrazol-3-yl}-2'-fluoro[1,1'-biphenyl]-4-yl)oxy]-1H-1,2,3-triazole-4-carboxylic acid: A82 (≠ I88), M83 (≠ T89), W111 (≠ M129), A112 (≠ Y130), T113 (≠ D131), S114 (= S132), S115 (≠ G133), Y133 (≠ P146), Y135 (≠ I148), R168 (vs. gap), L177 (≠ T182), Y180 (≠ L185), H232 (= H236), R235 (= R239)
Sites not aligning to the query:
2rdtA Crystal structure of human glycolate oxidase (go) in complex with cdst (see paper)
35% identity, 86% coverage: 48:337/339 of query aligns to 41:333/335 of 2rdtA
- active site: S109 (≠ A115), Y133 (≠ P146), T159 (≠ D174), D161 (= D176), K208 (= K212), H232 (= H236)
- binding 5-(dodecylthio)-1H-1,2,3-triazole-4-carboxylic acid: M83 (≠ T89), W111 (≠ M129), Y133 (≠ P146), R168 (vs. gap), H232 (= H236), R235 (= R239)
- binding flavin mononucleotide: A80 (= A86), T81 (≠ P87), A82 (≠ I88), S109 (≠ A115), Q131 (≠ G144), Y133 (≠ P146), T159 (≠ D174), K208 (= K212), H232 (= H236), G233 (= G237), R235 (= R239), D263 (= D267), G264 (= G268), G265 (= G269), R267 (= R271), G286 (= G290), R287 (= R291)
Sites not aligning to the query:
6w44A Crystal structure of hao1 in complex with indazole acid inhibitor - compound 4 (see paper)
35% identity, 86% coverage: 48:337/339 of query aligns to 38:329/330 of 6w44A
- active site: Y130 (≠ P146), D158 (= D176), H228 (= H236)
- binding flavin mononucleotide: A77 (= A86), T78 (≠ P87), A79 (≠ I88), S106 (≠ A115), Q128 (≠ G144), Y130 (≠ P146), K204 (= K212), H228 (= H236), G229 (= G237), R231 (= R239), D259 (= D267), G260 (= G268), R263 (= R271), G282 (= G290), R283 (= R291)
- binding 5-[methyl-[(2-propoxypyridin-3-yl)methyl]amino]-2~{H}-indazole-3-carboxylic acid: A79 (≠ I88), M80 (≠ T89), W108 (≠ M129), Y130 (≠ P146), R165 (vs. gap), L173 (vs. gap), A174 (≠ M183), V177 (≠ K186), H228 (= H236), R231 (= R239)
Sites not aligning to the query:
6a1hA Mandelate oxidase mutant-y128f with 5-deazariboflavin mononucleotide (see paper)
35% identity, 97% coverage: 1:328/339 of query aligns to 2:319/332 of 6a1hA
- active site: F126 (≠ I148), D154 (= D176), H227 (= H236)
- binding 1-deoxy-1-(7,8-dimethyl-2,4-dioxo-3,4-dihydropyrimido[4,5-b]quinolin-10(2H)-yl)-5-O-phosphono-D-ribitol: A74 (= A86), P75 (= P87), V76 (≠ I88), A77 (≠ T89), Q124 (≠ P146), F126 (≠ I148), T152 (≠ D174), K203 (= K212), H227 (= H236), R230 (= R239), D258 (= D267), G260 (= G269), R262 (= R271), G281 (= G290), R282 (= R291)
6a0oA Mandelate oxidase mutant-y128f with benzaldehyde (see paper)
35% identity, 97% coverage: 1:328/339 of query aligns to 2:319/332 of 6a0oA
- active site: F126 (≠ I148), D154 (= D176), H227 (= H236)
- binding flavin mononucleotide: P75 (= P87), V76 (≠ I88), A77 (≠ T89), Q124 (≠ P146), F126 (≠ I148), T152 (≠ D174), K203 (= K212), H227 (= H236), G228 (= G237), R230 (= R239), D258 (= D267), G260 (= G269), R262 (= R271), G281 (= G290), R282 (= R291)
- binding benzaldehyde: F22 (≠ G26), R42 (= R54), V43 (≠ Y55), F126 (≠ I148), V155 (vs. gap), M158 (vs. gap), R161 (vs. gap), F181 (≠ V190), H227 (= H236)
Sites not aligning to the query:
6a1rA Mandelate oxidase mutant-y128f with the n5-phenylacetyl-fmn adduct (see paper)
35% identity, 97% coverage: 1:328/339 of query aligns to 3:320/332 of 6a1rA
- active site: F127 (≠ I148), D155 (= D176), H228 (= H236)
- binding 1-deoxy-1-[7,8-dimethyl-2,4-dioxo-5-(phenylacetyl)-1,3,4,5-tetrahydrobenzo[g]pteridin-10(2H)-yl]-5-O-phosphono-D-ribitol: L24 (≠ R27), P76 (= P87), V77 (≠ I88), A78 (≠ T89), Q125 (≠ P146), F127 (≠ I148), T153 (≠ D174), M159 (vs. gap), F182 (≠ V190), K204 (= K212), H228 (= H236), G229 (= G237), R231 (= R239), D259 (= D267), G261 (= G269), R263 (= R271), G282 (= G290), R283 (= R291)
- binding magnesium ion: D259 (= D267), G260 (= G268), I262 (≠ V270), L280 (= L288)
6a3dA The crystal structure of mandelate oxidase y128f with 4-br-2-hydroxy- methylphenylacetate (see paper)
37% identity, 86% coverage: 37:328/339 of query aligns to 21:315/327 of 6a3dA
- active site: F122 (≠ I148), D150 (= D176), H223 (= H236)
- binding 1-deoxy-1-[(4aS)-4a-[(methoxycarbonyl)peroxy]-7,8-dimethyl-2,4-dioxo-3,4,4a,5-tetrahydrobenzo[g]pteridin-10(2H)-yl]-5-O-phosphono-D-ribitol: P71 (= P87), V72 (≠ I88), A73 (≠ T89), F122 (≠ I148), T148 (≠ D174), K199 (= K212), H223 (= H236), R226 (= R239), D254 (= D267), G255 (= G268), G256 (= G269), R258 (= R271), G277 (= G290), R278 (= R291)
5zztA The crystal structure of mandelate oxidase with 3,3-difluoro-2- hydroxy-3-phenylpropionic acid (see paper)
35% identity, 97% coverage: 1:328/339 of query aligns to 2:319/331 of 5zztA
- active site: Y126 (≠ I148), D154 (= D176), H227 (= H236)
- binding (2R)-3,3-difluoro-2-hydroxy-3-phenylpropanoic acid: F22 (≠ G26), Y126 (≠ I148), M158 (vs. gap), R161 (vs. gap), H227 (= H236), R230 (= R239)
- binding flavin mononucleotide: P75 (= P87), V76 (≠ I88), A77 (≠ T89), Q124 (≠ P146), Y126 (≠ I148), T152 (≠ D174), K203 (= K212), H227 (= H236), G228 (= G237), R230 (= R239), D258 (= D267), G259 (= G268), G260 (= G269), R262 (= R271), G281 (= G290), R282 (= R291)
6w4cA Crystal structure of hao1 in complex with indazole acid inhibitor - compound 5 (see paper)
35% identity, 86% coverage: 48:337/339 of query aligns to 39:335/336 of 6w4cA
- active site: Y131 (≠ P146), D159 (= D176), H234 (= H236)
- binding flavin mononucleotide: A78 (= A86), T79 (≠ P87), A80 (≠ I88), S107 (≠ A115), Q129 (≠ G144), Y131 (≠ P146), T157 (≠ D174), K210 (= K212), H234 (= H236), G235 (= G237), R237 (= R239), D265 (= D267), G266 (= G268), R269 (= R271), G288 (= G290), R289 (= R291)
- binding 5-[[3-[3-(dimethylamino)-1,2,4-oxadiazol-5-yl]-2-oxidanyl-phenyl]methylamino]-2~{H}-indazole-3-carboxylic acid: A80 (≠ I88), M81 (≠ T89), M84 (≠ T92), W109 (≠ M129), Y131 (≠ P146), R166 (vs. gap), A180 (≠ I181), V183 (≠ A184), H234 (= H236), R237 (= R239)
Sites not aligning to the query:
2w0uA Crystal structure of human glycolate oxidase in complex with the inhibitor 5-[(4-chlorophenyl)sulfanyl]- 1,2,3-thiadiazole-4- carboxylate. (see paper)
35% identity, 86% coverage: 48:337/339 of query aligns to 36:332/334 of 2w0uA
- active site: S104 (≠ A115), Y128 (≠ P146), T154 (≠ D174), D156 (= D176), K207 (= K212), H231 (= H236)
- binding 5-[(4-chlorophenyl)sulfanyl]-1,2,3-thiadiazole-4-carboxylate: M78 (≠ T89), W106 (≠ M129), Y128 (≠ P146), R163 (vs. gap), L176 (vs. gap), Y179 (≠ L185), V180 (≠ K186), H231 (= H236), R234 (= R239)
- binding flavin mononucleotide: A75 (= A86), T76 (≠ P87), A77 (≠ I88), S104 (≠ A115), Q126 (≠ G144), T154 (≠ D174), K207 (= K212), H231 (= H236), G232 (= G237), R234 (= R239), D262 (= D267), G263 (= G268), R266 (= R271), G285 (= G290), R286 (= R291)
Sites not aligning to the query:
7r4pA Structure of human hydroxyacid oxidase 1 bound with 6-amino-1-benzyl- 5-(methylamino)pyrimidine-2,4(1h,3h)-dione
34% identity, 86% coverage: 48:337/339 of query aligns to 38:336/337 of 7r4pA
- binding flavin mononucleotide: A77 (= A86), T78 (≠ P87), A79 (≠ I88), S106 (≠ A115), Q128 (≠ G144), Y130 (≠ P146), T156 (≠ D174), K211 (= K212), H235 (= H236), G236 (= G237), R238 (= R239), D266 (= D267), G267 (= G268), R270 (= R271), G289 (= G290), R290 (= R291)
- binding 6-amino-1-benzyl-5-(methylamino)pyrimidine-2,4(1H,3H)-dione: A79 (≠ I88), M80 (≠ T89), W108 (≠ M129), Y130 (≠ P146), R165 (vs. gap), L180 (= L180), H235 (= H236), R238 (= R239)
Sites not aligning to the query:
6a3tA The crystal structure of mandelate oxidase r163l with 2-hydroxy- phenylacetamide (see paper)
35% identity, 97% coverage: 1:328/339 of query aligns to 3:321/334 of 6a3tA
- active site: Y127 (≠ I148), D155 (= D174), H229 (= H236)
- binding 1-{5-[(1S)-2-amino-1-hydroxy-2-oxo-1-phenylethyl]-7,8-dimethyl-2,4-dioxo-1,2,3,4-tetrahydrobenzo[g]pteridine-5,10-diium-10-yl}-1-deoxy-5-O-phosphono-D-ribitol: F23 (≠ G26), P76 (= P87), V77 (≠ I88), Q125 (≠ P146), Y127 (≠ I148), T153 (≠ G172), M159 (≠ A178), K205 (= K212), H229 (= H236), R232 (= R239), D260 (= D267), G261 (= G268), G262 (= G269), R264 (= R271), G283 (= G290), R284 (= R291)
6a01A The crystal structure of mandelate oxidase y128f with 3,3-difluoro-2, 2-dihydroxy-3-phenylpropionic acid (see paper)
36% identity, 97% coverage: 1:328/339 of query aligns to 2:321/333 of 6a01A
- active site: F126 (≠ I148), D154 (= D176), H229 (= H236)
- binding 3,3-difluoro-2,2-dihydroxy-3-phenylpropanoic acid: F22 (≠ G26), F126 (≠ I148), M158 (vs. gap), R161 (≠ G179), H229 (= H236), R232 (= R239)
- binding flavin mononucleotide: P75 (= P87), V76 (≠ I88), A77 (≠ T89), Q124 (≠ P146), F126 (≠ I148), T152 (≠ D174), K205 (= K212), H229 (= H236), R232 (= R239), D260 (= D267), G262 (= G269), R264 (= R271), G283 (= G290), R284 (= R291)
6a1aA Mandelate oxidase mutant-y128f with 4-hydroxymandelic acid (see paper)
36% identity, 97% coverage: 1:328/339 of query aligns to 3:322/335 of 6a1aA
- active site: F127 (≠ I148), D155 (= D176), H230 (= H236)
- binding flavin mononucleotide: P76 (= P87), V77 (≠ I88), A78 (≠ T89), Q125 (≠ P146), F127 (≠ I148), T153 (≠ D174), K206 (= K212), H230 (= H236), R233 (= R239), D261 (= D267), G263 (= G269), R265 (= R271), G284 (= G290), R285 (= R291)
- binding (2S)-hydroxy(4-hydroxyphenyl)ethanoic acid: A40 (= A51), R43 (= R54), L107 (≠ M129), F127 (≠ I148), V156 (vs. gap), M159 (vs. gap), R162 (≠ G179), F184 (≠ V190), H230 (= H236), R233 (= R239), E243 (= E249)
Sites not aligning to the query:
6a1nA Mandelate oxidase mutant-y128f with (2r,3s)-3-fluoro-2-hydroxy-3- phenylpropanoic acid (see paper)
36% identity, 97% coverage: 1:328/339 of query aligns to 2:320/332 of 6a1nA
- active site: F126 (≠ I148), D154 (= D176), H228 (= H236)
- binding (2R,3S)-3-fluoro-2-hydroxy-3-phenylpropanoic acid: R42 (= R54), V43 (≠ Y55), A77 (≠ T89), Y78 (≠ G90), L106 (≠ M129), M158 (vs. gap), R161 (≠ G179), H228 (= H236), R231 (= R239), E241 (= E249)
- binding flavin mononucleotide: P75 (= P87), V76 (≠ I88), A77 (≠ T89), Q124 (≠ P146), F126 (≠ I148), T152 (≠ D174), K204 (= K212), H228 (= H236), G229 (= G237), R231 (= R239), D259 (= D267), G260 (= G268), G261 (= G269), R263 (= R271), G282 (= G290), R283 (= R291)
Sites not aligning to the query:
6a0gA The crystal structure of mandelate oxidase mutant y128f with b- phenyllactate (see paper)
36% identity, 97% coverage: 1:328/339 of query aligns to 2:320/331 of 6a0gA
- active site: F126 (≠ I148), D154 (= D176), H228 (= H236)
- binding flavin mononucleotide: P75 (= P87), V76 (≠ I88), A77 (≠ T89), Q124 (≠ P146), F126 (≠ I148), T152 (≠ D174), K204 (= K212), H228 (= H236), R231 (= R239), D259 (= D267), R263 (= R271), G282 (= G290), R283 (= R291)
- binding alpha-hydroxy-beta-phenyl-propionic acid: F22 (≠ G26), V43 (≠ Y55), L106 (≠ M129), M158 (vs. gap), H228 (= H236), R231 (= R239), E241 (= E249)
Sites not aligning to the query:
6a36A Mandelate oxidase mutant-y128f with the 3-fluoropyruvic acid fmn adduct (see paper)
36% identity, 97% coverage: 1:328/339 of query aligns to 2:320/331 of 6a36A
- active site: F126 (≠ I148), D154 (= D176), H228 (= H236)
- binding 1-{5-[(3S)-3-carboxy-4-fluoro-3-hydroxybutanoyl]-7,8-dimethyl-2,4-dioxo-1,3,4,5-tetrahydrobenzo[g]pteridin-10(2H)-yl}-1-deoxy-5-O-phosphono-D-ribitol: L23 (≠ R27), P75 (= P87), V76 (≠ I88), A77 (≠ T89), Q124 (≠ P146), F126 (≠ I148), T152 (≠ D174), M158 (vs. gap), R161 (≠ G179), K204 (= K212), H228 (= H236), R231 (= R239), D259 (= D267), G260 (= G268), G261 (= G269), R263 (= R271), G282 (= G290), R283 (= R291)
- binding 1-deoxy-1-{5-[(1S)-2-fluoro-1-hydroxyethyl]-7,8-dimethyl-2,4-dioxo-1,3,4,5-tetrahydrobenzo[g]pteridin-10(2H)-yl}-5-O-phosphono-D-ribitol: P75 (= P87), V76 (≠ I88), Q124 (≠ P146), F126 (≠ I148), T152 (≠ D174), K204 (= K212), H228 (= H236), R231 (= R239), D259 (= D267), G260 (= G268), G261 (= G269), R263 (= R271), G282 (= G290), R283 (= R291)
6a0bA The crystal structure of mandelate oxidase mutant y128f with (r)-3,3, 3-trifluoro-2-hydroxy-propionic acid (see paper)
36% identity, 97% coverage: 1:328/339 of query aligns to 2:320/332 of 6a0bA
- active site: F126 (≠ I148), D154 (= D176), H228 (= H236)
- binding (2R)-3,3,3-trifluoro-2-hydroxypropanoic acid: F126 (≠ I148), R161 (≠ G179), H228 (= H236), R231 (= R239)
- binding flavin mononucleotide: P75 (= P87), V76 (≠ I88), A77 (≠ T89), C104 (≠ P127), Q124 (≠ P146), F126 (≠ I148), T152 (≠ D174), K204 (= K212), H228 (= H236), R231 (= R239), D259 (= D267), G261 (= G269), R263 (= R271), G282 (= G290), R283 (= R291)
Query Sequence
>WP_015739079.1 NCBI__GCF_000024605.1:WP_015739079.1
MNLAEVRKTAREKLKGYCRVCPVCDGRACAGEVPGMGGVGTGASFRANVEALARYRLNLR
TIHSAKNPDTSLELFGLKLQTPILSAPITGTTYNMGGALSEREFIGAVITGSKMAGSLGF
SGDGADPTMYDSGIEAISAEGGWGIPIIKPRAQEAIVERIRRAEKAGAPAVGVDIDGAGL
ITMALKGHPVEPKTLDELKELIRSTRLPFILKGIMTVDEAELAVEAGAAAIVVSNHGGRI
LDHTPGVAEVLPEIVRAVGDRIVVLADGGVRSGVDALKLLALGARAVLVGRPIVIGAFGG
GAEGVKLVLEQMTEELRQAMILTGCSSLRDASPRILRPA
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory