SitesBLAST
Comparing WP_015798948.1 NCBI__GCF_000023265.1:WP_015798948.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
1t9cA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, sulfometuron methyl (see paper)
46% identity, 98% coverage: 3:559/569 of query aligns to 8:574/596 of 1t9cA
- active site: Y29 (≠ L24), G31 (= G26), G32 (= G27), A33 (= A28), I34 (= I29), E55 (= E49), T78 (= T72), F117 (= F111), Q118 (= Q112), E119 (= E113), K167 (= K161), R227 (= R220), M263 (= M256), V290 (= V283), V406 (= V388), L431 (= L413), G432 (= G414), M434 (= M416), D459 (= D441), N486 (= N468), E488 (≠ Y470), Q489 (≠ L471), M491 (= M473), V492 (= V474), W495 (= W477), L517 (≠ W501), G522 (= G506), L523 (≠ A507), K556 (≠ T541)
- binding methyl 2-[({[(4,6-dimethylpyrimidin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: G32 (= G27), V107 (= V101), P108 (= P102), F117 (= F111), K167 (= K161), D288 (= D281), R289 (= R282), W495 (= W477)
- binding flavin-adenine dinucleotide: R157 (= R151), G216 (= G210), A217 (≠ G211), G218 (= G212), N221 (≠ R215), T243 (= T236), L244 (= L237), Q245 (≠ L238), L261 (≠ P254), M263 (= M256), H264 (= H257), G283 (= G276), A284 (= A277), R285 (= R278), D287 (= D280), R289 (= R282), V290 (= V283), E316 (≠ D300), V317 (= V301), N321 (≠ E305), G334 (= G318), D335 (= D319), A336 (≠ L320), M411 (= M393), G429 (= G411), G430 (= G412)
- binding magnesium ion: D459 (= D441), N486 (= N468), E488 (≠ Y470)
1t9aA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, tribenuron methyl (see paper)
46% identity, 98% coverage: 3:559/569 of query aligns to 9:575/597 of 1t9aA
- active site: Y30 (≠ L24), G32 (= G26), G33 (= G27), A34 (= A28), I35 (= I29), E56 (= E49), T79 (= T72), F118 (= F111), Q119 (= Q112), E120 (= E113), K168 (= K161), R228 (= R220), M264 (= M256), V291 (= V283), V407 (= V388), L432 (= L413), G433 (= G414), M435 (= M416), D460 (= D441), N487 (= N468), E489 (≠ Y470), Q490 (≠ L471), M492 (= M473), V493 (= V474), W496 (= W477), L518 (≠ W501), G523 (= G506), L524 (≠ A507), K557 (≠ T541)
- binding methyl 2-[4-methoxy-6-methyl-1,3,5-trazin-2-yl(methyl)carbamoylsulfamoyl]benzoate: G33 (= G27), V108 (= V101), P109 (= P102), F118 (= F111), K168 (= K161), M264 (= M256), D289 (= D281), R290 (= R282), M492 (= M473), V493 (= V474), W496 (= W477)
- binding flavin-adenine dinucleotide: R158 (= R151), G217 (= G210), A218 (≠ G211), G219 (= G212), N222 (≠ R215), T244 (= T236), L245 (= L237), Q246 (≠ L238), L262 (≠ P254), M264 (= M256), H265 (= H257), G284 (= G276), A285 (= A277), R286 (= R278), D288 (= D280), R290 (= R282), V291 (= V283), E317 (≠ D300), V318 (= V301), N322 (≠ E305), G335 (= G318), D336 (= D319), A337 (≠ L320), Q411 (= Q392), M412 (= M393), G430 (= G411), G431 (= G412)
- binding magnesium ion: D460 (= D441), N487 (= N468), E489 (≠ Y470)
- binding propyl trihydrogen diphosphate: V407 (= V388), G408 (= G389), Q409 (= Q390), H410 (= H391), M435 (= M416), G459 (= G440), D460 (= D441), A461 (≠ G442), S462 (= S443), N487 (= N468), E489 (≠ Y470), Q490 (≠ L471), G491 (= G472), M492 (= M473)
- binding 5-{[ethyl(methyl)amino]methyl}-2-methyl-5,6-dihydropyrimidin-4-amine: G433 (= G414), M435 (= M416), M465 (= M446)
1t9dA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, metsulfuron methyl (see paper)
46% identity, 98% coverage: 3:559/569 of query aligns to 8:574/596 of 1t9dA
- active site: Y29 (≠ L24), G31 (= G26), G32 (= G27), A33 (= A28), I34 (= I29), E55 (= E49), T78 (= T72), F117 (= F111), Q118 (= Q112), E119 (= E113), K167 (= K161), R227 (= R220), M263 (= M256), V290 (= V283), V406 (= V388), L431 (= L413), G432 (= G414), M434 (= M416), D459 (= D441), N486 (= N468), E488 (≠ Y470), Q489 (≠ L471), M491 (= M473), V492 (= V474), W495 (= W477), L517 (≠ W501), G522 (= G506), L523 (≠ A507), K556 (≠ T541)
- binding methyl 2-[({[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: G32 (= G27), A33 (= A28), V107 (= V101), P108 (= P102), F117 (= F111), K167 (= K161), M263 (= M256), D288 (= D281), R289 (= R282), W495 (= W477)
- binding flavin-adenine dinucleotide: R157 (= R151), G216 (= G210), A217 (≠ G211), G218 (= G212), N221 (≠ R215), T243 (= T236), L244 (= L237), Q245 (≠ L238), M260 (= M253), L261 (≠ P254), H264 (= H257), G283 (= G276), A284 (= A277), R285 (= R278), D287 (= D280), R289 (= R282), V290 (= V283), E316 (≠ D300), V317 (= V301), N321 (≠ E305), G334 (= G318), D335 (= D319), A336 (≠ L320), Q410 (= Q392), M411 (= M393), G429 (= G411), G430 (= G412)
- binding magnesium ion: D459 (= D441), N486 (= N468), E488 (≠ Y470)
- binding 2,5-dimethyl-pyrimidin-4-ylamine: E55 (= E49), P81 (= P75), Q118 (= Q112), G432 (= G414), M434 (= M416), M464 (= M446)
1n0hA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorimuron ethyl (see paper)
46% identity, 98% coverage: 3:559/569 of query aligns to 10:577/599 of 1n0hA
- active site: Y31 (≠ L24), G33 (= G26), G34 (= G27), A35 (= A28), I36 (= I29), E57 (= E49), T80 (= T72), F119 (= F111), Q120 (= Q112), E121 (= E113), K169 (= K161), R230 (= R220), M266 (= M256), V293 (= V283), V409 (= V388), L434 (= L413), G435 (= G414), M437 (= M416), D462 (= D441), N489 (= N468), E491 (≠ Y470), Q492 (≠ L471), M494 (= M473), V495 (= V474), W498 (= W477), L520 (≠ W501), G525 (= G506), L526 (≠ A507), K559 (≠ T541)
- binding 4-{[(4'-amino-2'-methylpyrimidin-5'-yl)methyl]amino}pent-3-enyl diphosphate: V409 (= V388), G410 (= G389), Q411 (= Q390), H412 (= H391), G435 (= G414), M437 (= M416), G461 (= G440), D462 (= D441), A463 (≠ G442), S464 (= S443), M467 (= M446), N489 (= N468), E491 (≠ Y470), Q492 (≠ L471), G493 (= G472), V495 (= V474)
- binding 2-[[[[(4-chloro-6-methoxy-2-pyrimidinyl)amino]carbonyl]amino]sulfonyl]benzoic acid ethyl ester: G34 (= G27), A35 (= A28), V109 (= V101), P110 (= P102), F119 (= F111), K169 (= K161), M266 (= M256), D291 (= D281), R292 (= R282), V495 (= V474), W498 (= W477)
- binding flavin-adenine dinucleotide: R159 (= R151), G219 (= G210), A220 (≠ G211), G221 (= G212), N224 (≠ R215), T246 (= T236), L247 (= L237), Q248 (≠ L238), L264 (≠ P254), G265 (= G255), M266 (= M256), H267 (= H257), G286 (= G276), A287 (= A277), R288 (= R278), D290 (= D280), R292 (= R282), V293 (= V283), E319 (≠ D300), V320 (= V301), N324 (≠ E305), G337 (= G318), D338 (= D319), A339 (≠ L320), M414 (= M393), G432 (= G411), G433 (= G412)
- binding magnesium ion: D462 (= D441), N489 (= N468), E491 (≠ Y470)
- binding thiamine diphosphate: Y31 (≠ L24), E57 (= E49), P83 (= P75)
6u9dB Saccharomyces cerevisiae acetohydroxyacid synthase (see paper)
46% identity, 98% coverage: 3:559/569 of query aligns to 12:585/607 of 6u9dB
- active site: Y33 (≠ L24), G35 (= G26), G36 (= G27), A37 (= A28), I38 (= I29), E59 (= E49), T82 (= T72), F121 (= F111), Q122 (= Q112), E123 (= E113), K171 (= K161), M274 (= M256), V301 (= V283), V417 (= V388), G443 (= G414), M445 (= M416), D470 (= D441), N497 (= N468), E499 (≠ Y470), Q500 (≠ L471), M502 (= M473), V503 (= V474), W506 (= W477)
- binding methyl 2-[(4,6-dimethoxypyrimidin-2-yl)carbamoylsulfamoylmethyl]benzoate: G36 (= G27), V111 (= V101), P112 (= P102), F121 (= F111), K171 (= K161), D299 (= D281), R300 (= R282), M502 (= M473), W506 (= W477)
- binding flavin-adenine dinucleotide: R161 (= R151), A228 (≠ G211), G229 (= G212), N232 (≠ R215), T254 (= T236), L255 (= L237), Q256 (≠ L238), L272 (≠ P254), M274 (= M256), G294 (= G276), R296 (= R278), D298 (= D280), R300 (= R282), V301 (= V283), E327 (≠ D300), V328 (= V301), N332 (≠ E305), D346 (= D319), A347 (≠ L320), M422 (= M393), G440 (= G411), G441 (= G412)
- binding magnesium ion: D470 (= D441), N497 (= N468)
- binding thiamine diphosphate: E59 (= E49), P85 (= P75), V417 (= V388), G418 (= G389), Q419 (= Q390), H420 (= H391), G443 (= G414), M445 (= M416), A471 (≠ G442), S472 (= S443), N497 (= N468), E499 (≠ Y470), Q500 (≠ L471), G501 (= G472), M502 (= M473), V503 (= V474)
1t9bB Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorsulfuron (see paper)
46% identity, 98% coverage: 3:559/569 of query aligns to 8:573/595 of 1t9bB
- active site: Y29 (≠ L24), G31 (= G26), G32 (= G27), A33 (= A28), I34 (= I29), E55 (= E49), T78 (= T72), F117 (= F111), Q118 (= Q112), E119 (= E113), K167 (= K161), R226 (= R220), M262 (= M256), V289 (= V283), V405 (= V388), L430 (= L413), G431 (= G414), M433 (= M416), D458 (= D441), N485 (= N468), E487 (≠ Y470), Q488 (≠ L471), M490 (= M473), V491 (= V474), W494 (= W477), L516 (≠ W501), G521 (= G506), L522 (≠ A507), K555 (≠ T541)
- binding 1-(2-chlorophenylsulfonyl)-3-(4-methoxy-6-methyl-l,3,5-triazin-2-yl)urea: V107 (= V101), P108 (= P102), D287 (= D281), R288 (= R282), M490 (= M473), W494 (= W477)
- binding flavin-adenine dinucleotide: R157 (= R151), G215 (= G210), A216 (≠ G211), G217 (= G212), N220 (≠ R215), T242 (= T236), L243 (= L237), Q244 (≠ L238), M259 (= M253), L260 (≠ P254), M262 (= M256), H263 (= H257), G282 (= G276), A283 (= A277), R284 (= R278), D286 (= D280), R288 (= R282), V289 (= V283), E315 (≠ D300), V316 (= V301), N320 (≠ E305), G333 (= G318), D334 (= D319), A335 (≠ L320), Q409 (= Q392), M410 (= M393), G428 (= G411), G429 (= G412)
- binding magnesium ion: D458 (= D441), N485 (= N468), E487 (≠ Y470)
P07342 Acetolactate synthase catalytic subunit, mitochondrial; Acetohydroxy-acid synthase catalytic subunit; AHAS; ALS; EC 2.2.1.6 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
46% identity, 98% coverage: 3:559/569 of query aligns to 92:665/687 of P07342