Comparing WP_015799097.1 NCBI__GCF_000023265.1:WP_015799097.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
6pnzA The structure of the aspartate transcarbamoylase trimer from staphylococcus aureus complexed with pala at 2.27 resolution.
36% identity, 96% coverage: 5:302/310 of query aligns to 4:291/293 of 6pnzA
3r7lA Crystal structure of pala-bound aspartate transcarbamoylase from bacillus subtilis (see paper)
37% identity, 89% coverage: 25:300/310 of query aligns to 24:286/290 of 3r7lA
P05654 Aspartate carbamoyltransferase catalytic subunit; Aspartate transcarbamylase; ATCase; EC 2.1.3.2 from Bacillus subtilis (strain 168) (see paper)
37% identity, 85% coverage: 36:300/310 of query aligns to 34:286/304 of P05654
Sites not aligning to the query:
3r7fA Crystal structure of cp-bound aspartate transcarbamoylase from bacillus subtilis (see paper)
37% identity, 89% coverage: 25:300/310 of query aligns to 24:286/291 of 3r7fA
Sites not aligning to the query:
3r7dA Crystal structure of unliganded aspartate transcarbamoylase from bacillus subtilis (see paper)
37% identity, 89% coverage: 25:300/310 of query aligns to 24:286/291 of 3r7dA
Sites not aligning to the query:
P20054 Multifunctional protein pyr1-3; EC 6.3.5.5; EC 3.5.1.2; EC 6.3.4.16; EC 2.1.3.2; EC 3.5.2.3 from Dictyostelium discoideum (Social amoeba)
36% identity, 91% coverage: 26:307/310 of query aligns to 1949:2224/2225 of P20054
Sites not aligning to the query:
5g1nE Aspartate transcarbamoylase domain of human cad bound to pala (see paper)
35% identity, 85% coverage: 36:299/310 of query aligns to 42:300/307 of 5g1nE
P05990 Multifunctional protein r; Protein rudimentary; EC 6.3.5.5; EC 3.5.1.2; EC 6.3.4.16; EC 2.1.3.2; EC 3.5.2.3 from Drosophila melanogaster (Fruit fly) (see 2 papers)
36% identity, 85% coverage: 36:299/310 of query aligns to 1955:2213/2224 of P05990
Sites not aligning to the query:
P08955 Multifunctional protein CAD; Carbamoyl phosphate synthetase 2-aspartate transcarbamylase-dihydroorotase; EC 6.3.5.5; EC 3.5.1.2; EC 6.3.4.16; EC 2.1.3.2; EC 3.5.2.3 from Mesocricetus auratus (Golden hamster) (see paper)
35% identity, 85% coverage: 36:299/310 of query aligns to 1960:2218/2225 of P08955
Sites not aligning to the query:
P27708 Multifunctional protein CAD; Carbamoyl phosphate synthetase 2-aspartate transcarbamylase-dihydroorotase; EC 6.3.5.5; EC 3.5.1.2; EC 6.3.4.16; EC 2.1.3.2; EC 3.5.2.3 from Homo sapiens (Human) (see 7 papers)
35% identity, 85% coverage: 36:299/310 of query aligns to 1960:2218/2225 of P27708
Sites not aligning to the query:
4bjhB Crystal structure of the aquifex reactor complex formed by dihydroorotase (h180a, h232a) with dihydroorotate and aspartate transcarbamoylase with n-(phosphonacetyl)-l-aspartate (pala) (see paper)
36% identity, 84% coverage: 43:302/310 of query aligns to 39:289/291 of 4bjhB
3d6nB Crystal structure of aquifex dihydroorotase activated by aspartate transcarbamoylase (see paper)
36% identity, 84% coverage: 43:302/310 of query aligns to 39:289/291 of 3d6nB
5g1pA Aspartate transcarbamoylase domain of human cad bound to carbamoyl phosphate (see paper)
36% identity, 85% coverage: 36:299/310 of query aligns to 39:285/292 of 5g1pA
7zstB Crystal structure of truncated aspartate transcarbamoylase from plasmodium falciparum in complex with fla-01 (see paper)
30% identity, 93% coverage: 12:299/310 of query aligns to 23:319/329 of 7zstB
4eknB Structure of the catalytic chain of methanococcus jannaschii aspartate transcarbamoylase in a hexagonal crystal form (see paper)
35% identity, 96% coverage: 8:305/310 of query aligns to 16:302/304 of 4eknB
7zidB Crystal structure of truncated aspartate transcarbamoylase from plasmodium falciparum in complex with bda-14 (see paper)
29% identity, 93% coverage: 12:299/310 of query aligns to 22:321/331 of 7zidB
1ml4A The pala-liganded aspartate transcarbamoylase catalytic subunit from pyrococcus abyssi (see paper)
34% identity, 85% coverage: 37:299/310 of query aligns to 42:300/307 of 1ml4A
Q09794 Multifunctional protein ura1; Pyrimidine-specific carbamoyl phosphate synthase-aspartate carbamoyl transferase; CPSase-ATCase; EC 6.3.5.5; EC 3.5.1.2; EC 6.3.4.16; EC 2.1.3.2 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
31% identity, 85% coverage: 38:299/310 of query aligns to 1975:2233/2244 of Q09794
Sites not aligning to the query:
8bplA Aspartate transcarbamoylase mutant (n2045c, r2238c) from chaetomium thermophilum cad-like bound to carbamoyl phosphate (see paper)
33% identity, 85% coverage: 36:299/310 of query aligns to 52:311/316 of 8bplA
6ys6B Arabidopsis aspartate transcarbamoylase complex with pala (see paper)
36% identity, 92% coverage: 23:308/310 of query aligns to 30:312/312 of 6ys6B
>WP_015799097.1 NCBI__GCF_000023265.1:WP_015799097.1
MSATFLGVEQLDAGRLGVLGARVDELVHGAAASRCLEGRRVALLFLEPSTRTALSFEAAI
DRLGGRTVRIDPESSSLVKDESLRDTLRVLAAQGTSGVVVRAPWVGTADVVARFFDGIVV
NAGDGVGQHPTQALQDVCVLARTRGGRADAFGALEGCRVAIVGDLRHSRVARSVGRLLAS
VGAEVVGVAPREWSLDPKALGAVGVTDGIDDVLDEVDVFYMLRIQHERVGANERVDLSGY
RARFQLSGHRLERARPDAVVLHPGPVNRGVELDDIVLSSPRMLDGLQYAYGVPTRVAVLE
ALAEEAGWGL
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory