SitesBLAST
Comparing WP_015799203.1 NCBI__GCF_000023265.1:WP_015799203.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
2zsjA Crystal structure of threonine synthase from aquifex aeolicus vf5
55% identity, 97% coverage: 12:355/356 of query aligns to 1:350/350 of 2zsjA
- active site: K61 (= K70), T85 (= T94), Q218 (= Q227), A222 (= A231), A240 (= A249), T317 (= T322)
- binding pyridoxal-5'-phosphate: F60 (= F69), K61 (= K70), N87 (= N96), V186 (= V195), G187 (= G196), N188 (= N197), A189 (= A198), G190 (= G199), N191 (= N200), A240 (= A249), T317 (= T322), G318 (= G323)
3aexA Catalytic intermediate analogue of threonine synthase from thermus thermophilus hb8 (see paper)
59% identity, 96% coverage: 14:355/356 of query aligns to 3:350/351 of 3aexA
- active site: K61 (= K70), T85 (= T94), P212 (= P221), G216 (= G225), Q218 (= Q227), A240 (= A249), T317 (= T322)
- binding (3E)-4-{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}-2-oxobut-3-enoic acid: K61 (= K70), S84 (= S93), T85 (= T94), N87 (= N96), T88 (= T97), V186 (= V195), G187 (= G196), N188 (= N197), A189 (= A198), G190 (= G199), N191 (= N200), A240 (= A249), I241 (= I250), E287 (= E296), T317 (= T322)
- binding phosphate ion: K61 (= K70), T88 (= T97), N154 (= N163), S155 (= S164), R160 (= R169), N188 (= N197)
1v7cA Crystal structure of threonine synthase from thermus thermophilus hb8 in complex with a substrate analogue (see paper)
59% identity, 96% coverage: 14:355/356 of query aligns to 3:350/351 of 1v7cA
- active site: K61 (= K70), T85 (= T94), P212 (= P221), G216 (= G225), Q218 (= Q227), A240 (= A249), T317 (= T322)
- binding (2e)-2-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino]-5-phosphonopent-2-enoic acid: K61 (= K70), S84 (= S93), T85 (= T94), N87 (= N96), T88 (= T97), F134 (= F143), N154 (= N163), S155 (= S164), R160 (= R169), V186 (= V195), G187 (= G196), N188 (= N197), A189 (= A198), G190 (= G199), N191 (= N200), A240 (= A249), I241 (= I250), E287 (= E296), T317 (= T322)
3aeyA Apo form of threonine synthase from thermus thermophilus hb8 (see paper)
59% identity, 96% coverage: 14:355/356 of query aligns to 2:349/350 of 3aeyA
- active site: K60 (= K70), T84 (= T94), P211 (= P221), G215 (= G225), Q217 (= Q227), A239 (= A249), T316 (= T322)
- binding sulfate ion: K60 (= K70), K60 (= K70), G85 (= G95), N86 (= N96), T87 (= T97), T87 (= T97), S154 (= S164), R159 (= R169), N187 (= N197), R228 (≠ E238), V230 (= V240), E231 (= E241), R232 (≠ H242), A239 (= A249)
1uimA Crystal structure of threonine synthase from thermus thermophilus hb8, orthorhombic crystal form (see paper)
59% identity, 96% coverage: 14:355/356 of query aligns to 3:350/350 of 1uimA
- active site: K61 (= K70), T85 (= T94), P212 (= P221), G216 (= G225), Q218 (= Q227), A240 (= A249), T317 (= T322)
- binding pyridoxal-5'-phosphate: F60 (= F69), K61 (= K70), N87 (= N96), G187 (= G196), N188 (= N197), A189 (= A198), G190 (= G199), N191 (= N200), A240 (= A249), E287 (= E296), T317 (= T322), G318 (= G323)
P9WG59 Threonine synthase; TS; EC 4.2.3.1 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
61% identity, 90% coverage: 13:334/356 of query aligns to 12:338/360 of P9WG59
- K69 (= K70) modified: N6-(pyridoxal phosphate)lysine
- N95 (= N96) binding pyridoxal 5'-phosphate
- K151 (≠ Q152) modified: Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)
- GNAGN 196:200 (= GNAGN 196:200) binding pyridoxal 5'-phosphate
- T326 (= T322) binding pyridoxal 5'-phosphate
2d1fA Structure of mycobacterium tuberculosis threonine synthase (see paper)
61% identity, 90% coverage: 13:334/356 of query aligns to 3:329/349 of 2d1fA
- active site: K60 (= K70), T84 (= T94), D209 (≠ T218), R213 (= R222), L215 (≠ V224), A240 (= A249), T317 (= T322)
- binding pyridoxal-5'-phosphate: F59 (= F69), K60 (= K70), N86 (= N96), V186 (= V195), G187 (= G196), N188 (= N197), A189 (= A198), G190 (= G199), N191 (= N200), A240 (= A249), T317 (= T322)
A0R220 Threonine synthase; TS; EC 4.2.3.1 from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis) (see paper)
58% identity, 97% coverage: 13:356/356 of query aligns to 12:360/360 of A0R220
- K151 (≠ Q152) modified: Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)
6cgqB Threonine synthase from bacillus subtilis atcc 6633 with plp and plp- ala (see paper)
54% identity, 95% coverage: 13:349/356 of query aligns to 1:341/345 of 6cgqB
- active site: K58 (= K70), T82 (= T94), E214 (≠ Q227), S218 (≠ A231), A236 (= A249), T313 (= T322)
- binding (E)-N-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)-L-alanine: K58 (= K70), S81 (= S93), T82 (= T94), N84 (= N96), T85 (= T97), V183 (= V195), G184 (= G196), N185 (= N197), A186 (= A198), N188 (= N200), A236 (= A249), I237 (= I250), E283 (= E296), T313 (= T322)
- binding phosphate ion: K58 (= K70), T85 (= T97), N151 (= N163), S152 (= S164), R157 (= R169), N185 (= N197)
6nmxA Threonine synthase from bacillus subtilis atcc 6633 with plp and appa (see paper)
54% identity, 95% coverage: 13:349/356 of query aligns to 3:343/350 of 6nmxA
- active site: K60 (= K70), T84 (= T94), E216 (≠ Q227), S220 (≠ A231), A238 (= A249), T315 (= T322)
- binding (2E,3Z)-2-{[(Z)-{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4(1H)-ylidene}methyl]imino}-5-phosphonopent-3-enoic acid: K60 (= K70), S83 (= S93), T84 (= T94), N86 (= N96), T87 (= T97), F133 (= F143), N153 (= N163), S154 (= S164), R159 (= R169), V185 (= V195), G186 (= G196), N187 (= N197), A188 (= A198), G189 (= G199), N190 (= N200), A238 (= A249), I239 (= I250), E285 (= E296), T315 (= T322)
6cgqA Threonine synthase from bacillus subtilis atcc 6633 with plp and plp- ala (see paper)
53% identity, 94% coverage: 15:349/356 of query aligns to 1:333/339 of 6cgqA
- active site: K56 (= K70), T80 (= T94), E206 (≠ Q227), S210 (≠ A231), A228 (= A249), T305 (= T322)
- binding pyridoxal-5'-phosphate: F55 (= F69), K56 (= K70), N82 (= N96), V175 (= V195), G176 (= G196), N177 (= N197), A178 (= A198), G179 (= G199), N180 (= N200), A228 (= A249), E275 (= E296), T305 (= T322), G306 (= G323)
2c2bA Crystallographic structure of arabidopsis thaliana threonine synthase complexed with pyridoxal phosphate and s-adenosylmethionine (see paper)
33% identity, 97% coverage: 5:349/356 of query aligns to 58:436/444 of 2c2bA
- binding pyridoxal-5'-phosphate: F127 (= F69), K128 (= K70), D159 (≠ N96), G259 (≠ V195), G260 (= G196), N261 (= N197), L262 (≠ A198), G263 (= G199), N264 (= N200), A321 (= A249), H369 (≠ A298), T397 (= T322)
- binding s-adenosylmethionine: S64 (≠ L11), T65 (≠ R12), W66 (= W13), P67 (= P14), G69 (vs. gap), S90 (= S34), F92 (≠ G36), N97 (≠ L41), L98 (= L42), W100 (≠ Y44), W115 (≠ F57), W115 (≠ F57), Q246 (= Q183), F247 (≠ L184)
Q9S7B5 Threonine synthase 1, chloroplastic; Protein METHIONINE OVER-ACCUMULATOR 2; EC 4.2.3.1 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
33% identity, 97% coverage: 5:349/356 of query aligns to 133:511/526 of Q9S7B5
- N172 (≠ L41) binding S-adenosyl-L-methionine
- L173 (= L42) binding S-adenosyl-L-methionine
- K181 (≠ A54) binding in monomer B; binding in monomer A
- N187 (vs. gap) binding in monomer B
- L205 (≠ R72) mutation to R: In mto2-1; causes a strong decrease in the concentration of soluble threonine and over-accumulation of methionine.
2c2gA Crystal structure of threonine synthase from arabidopsis thaliana in complex with its cofactor pyridoxal phosphate (see paper)
32% identity, 97% coverage: 5:349/356 of query aligns to 76:438/448 of 2c2gA
8y1jA Structure of the pyridoxal 5'-phosphate-dependent (plp) threonine deaminase ilva1 from pseudomonas aeruginosa pao1 (see paper)
31% identity, 80% coverage: 40:323/356 of query aligns to 20:305/502 of 8y1jA
Sites not aligning to the query:
2gn2A Crystal structure of tetrameric biodegradative threonine deaminase (tdcb) from salmonella typhimurium in complex with cmp at 2.5a resolution (hexagonal form) (see paper)
27% identity, 70% coverage: 47:296/356 of query aligns to 33:280/326 of 2gn2A
- active site: K56 (= K70), A81 (≠ T94), Q207 (= Q227), V211 (vs. gap), G213 (vs. gap), G235 (≠ A249)
- binding cytidine-5'-monophosphate: R51 (≠ P65), T52 (= T66), G53 (= G67), A114 (≠ Q128), D117 (≠ L131), Y118 (= Y132)
Sites not aligning to the query:
5c3uA Crystal structure of a fungal l-serine ammonia-lyase from rhizomucor miehei (see paper)
29% identity, 77% coverage: 40:313/356 of query aligns to 7:280/315 of 5c3uA
- active site: K37 (= K70), G63 (≠ T94), E191 (≠ Q227), S195 (≠ A231), A197 (vs. gap), S219 (≠ A249)
- binding pyridoxal-5'-phosphate: K37 (= K70), N65 (= N96), S132 (= S164), P163 (= P194), G165 (= G196), G166 (≠ N197), G167 (≠ A198), G168 (= G199), S219 (≠ A249)
Sites not aligning to the query:
7nbgDDD structure of human serine racemase in complex with DSiP fragment Z52314092, XChem fragment screen (see paper)
29% identity, 73% coverage: 48:307/356 of query aligns to 31:286/310 of 7nbgDDD
- active site: K53 (= K70), S76 (≠ T94), E202 (≠ A232), A206 (vs. gap), D208 (vs. gap), G231 (≠ A249)
- binding calcium ion: E202 (≠ A232), A206 (vs. gap), D208 (vs. gap)
- binding magnesium ion: N239 (≠ A256)
- binding ortho-xylene: S76 (≠ T94), Q81 (≠ A99), I96 (≠ V114), Y113 (= Y132)
- binding pyridoxal-5'-phosphate: F52 (= F69), K53 (= K70), N78 (= N96), G177 (= G196), G178 (≠ N197), G179 (≠ A198), G180 (= G199), M181 (≠ N200), G231 (≠ A249), V232 (≠ I250), E275 (= E296), T277 (≠ A298)
Sites not aligning to the query:
3l6bA X-ray crystal structure of human serine racemase in complex with malonate a potent inhibitor (see paper)
29% identity, 73% coverage: 48:307/356 of query aligns to 32:287/322 of 3l6bA
- active site: K54 (= K70), S77 (≠ T94), E203 (≠ A232), A207 (vs. gap), D209 (vs. gap), G232 (≠ A249), T278 (≠ A298)
- binding malonate ion: K54 (= K70), S76 (= S93), S77 (≠ T94), N79 (= N96), H80 (≠ T97), R128 (vs. gap), G232 (≠ A249)
- binding manganese (ii) ion: E203 (≠ A232), A207 (vs. gap), D209 (vs. gap)
- binding pyridoxal-5'-phosphate: F53 (= F69), K54 (= K70), N79 (= N96), G178 (= G196), G179 (≠ N197), G180 (≠ A198), G181 (= G199), M182 (≠ N200), V233 (≠ I250), E276 (= E296), T278 (≠ A298)
Sites not aligning to the query:
6zspAAA serine racemase bound to atp and malonate. (see paper)
29% identity, 73% coverage: 48:307/356 of query aligns to 31:284/320 of 6zspAAA
- active site: K53 (= K70), S74 (≠ T94), E200 (≠ A232), A204 (vs. gap), D206 (vs. gap), G229 (≠ A249)
- binding adenosine-5'-triphosphate: K48 (≠ P65), T49 (= T66), Q79 (≠ A99), Y111 (= Y132), E266 (≠ R289), R267 (≠ E290), K269 (≠ S292)
- binding magnesium ion: E200 (≠ A232), A204 (vs. gap), D206 (vs. gap)
- binding malonate ion: K53 (= K70), S73 (= S93), S74 (≠ T94), N76 (= N96), H77 (≠ T97), R125 (vs. gap), G229 (≠ A249), S232 (vs. gap)
Sites not aligning to the query:
Query Sequence
>WP_015799203.1 NCBI__GCF_000023265.1:WP_015799203.1
MAHDDGVVRRLRWPGILEAYRSALPIEDGAELVSLGEGGTLLRYAPHLSERVGARVFLKL
EGLNPTGSFKDRGMALAVTNAKARGARAVICASTGNTSAAAAAYARAAGLASVVVVPSAG
IARGKLAQALLYGARVVAIEGSFDDALVAVRQLAEADGVALVNSVNPDRLEGQKTVAFEI
VDQLGDAPTVQVMPVGNAGNITASWRGYREAHAAGATTRLPRMVGVQAEGAAPIVRGEVV
EHPETIASAIRIGRPASWQGALNATSDSGGTVLAVSDDAILEAYILLAREESVFCEPASA
ASVAGLLRLDLARSDTVVCILTGHGLKDPDTALRTVEGPVPSSAGLDAIARAAGLA
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory